Lynn R. Fraser
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Lynn R. Fraserphilosophy Degrees
Philosophy
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Philosophy Biology
Lynn R. Fraser's Degrees
- Doctorate Medicine University of California, San Francisco
- PhD Reproductive Biology University of California, San Francisco
Why Is Lynn R. Fraser Influential?
(Suggest an Edit or Addition)Lynn R. Fraser's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Multiple gestation pregnancy (2000) (351)
- Ca2+‐Regulating mechanisms that modulate bull sperm capacitation and acrosomal exocytosis as determined by chlortetracycline analysis (1995) (265)
- A glycolytic product is obligatory for initiation of the sperm acrosome reaction and whiplash motility required for fertilization in the mouse. (1981) (210)
- The relationship between sperm concentration and fertilization in vitro of mouse eggs. (1975) (184)
- 17beta-Estradiol and environmental estrogens significantly affect mammalian sperm function. (2003) (165)
- Ca(2+)-related changes in the capacitation state of human spermatozoa assessed by a chlortetracycline fluorescence assay. (1993) (157)
- Minimum and maximum extracellular Ca2+ requirements during mouse sperm capacitation and fertilization in vitro. (1987) (149)
- Functional analysis using chlortetracycline fluorescence and in vitro fertilization of frozen-thawed ejaculated boar spermatozoa incubated in a protein-free chemically defined medium. (1995) (141)
- Motility patterns in mouse spermatozoa before and after capacitation. (1977) (137)
- Mouse sperm capacitation in vitro involves loss of a surface-associated inhibitory component. (1984) (127)
- The effect of PMSG dose on the incidence of chromosomal anomalies in mouse embryos fertilized in vitro. (1977) (122)
- Ca2+ Is Required for Mouse Sperm Capacitation and Fertilization In Vitro (1982) (109)
- Dibutyryl cyclic AMP decreases capacitation time in vitro in mouse spermatozoa. (1981) (104)
- Europe the continent with the lowest fertility. (2010) (102)
- The modulation of sperm function by fertilization promoting peptide. (1998) (95)
- Metabolic and surface events in fertilization. (1988) (94)
- p-Aminobenzamidine, an acrosin inhibitor, inhibits mouse sperm penetration of the zona pellucida but not the acrosome reaction. (1982) (91)
- Characterization of a decapacitation factor associated with epididymal mouse spermatozoa. (1990) (90)
- Effects of estrogenic xenobiotics on human and mouse spermatozoa. (2006) (87)
- The “switching on” of mammalian spermatozoa: Molecular events involved in promotion and regulation of capacitation (2010) (87)
- Expression of capacitation-dependent changes in chlortetracycline fluorescence patterns in mouse spermatozoa requires a suitable glycolysable substrate. (1990) (87)
- Evidence for multiple distinctly localized adenylyl cyclase isoforms in mammalian spermatozoa (2003) (86)
- A mouse sperm decapacitation factor receptor is phosphatidylethanolamine-binding protein 1. (2005) (80)
- Accelerated mouse sperm penetration in vitro in the presence of caffeine. (1979) (77)
- Potassium ions modulate expression of mouse sperm fertilizing ability, acrosome reaction and hyperactivated motility in vitro. (1983) (76)
- Cyclic AMP-dependent phosphorylation of epididymal mouse sperm proteins during capacitation in vitro: identification of an M(r) 95,000 phosphotyrosine-containing protein. (1993) (75)
- Evidence for Ca2+‐dependent ATPase activity, stimulated by decapacitation factor and calmodulin, in mouse sperm (1996) (72)
- Ca2+-related changes in the mouse sperm capacitation state: a possible role for Ca2+-ATPase (1992) (72)
- Protein kinase C activation during progesterone-stimulated acrosomal exocytosis in human spermatozoa. (1996) (71)
- ESHRE basic semen analysis courses 1995-1999: immediate beneficial effects of standardized training. (2002) (70)
- Albumin is required to support the acrosome reaction but not capacitation in mouse spermatozoa in vitro. (1985) (69)
- Stimulating effect of pyroglutamylglutamylprolineamide, a prostatic, TRH‐related tripeptide, on mouse sperm capacitation and fertilizing ability in vitro (1994) (68)
- Ionic control of sperm function. (1995) (67)
- Genetic aspects of female reproduction. (2008) (67)
- Adenosine analogues with specificity for A2 receptors bind to mouse spermatozoa and stimulate adenylate cyclase activity in uncapacitated suspensions. (1993) (66)
- Strontium supports capacitation and the acrosome reaction in mouse sperm and rapidly activates mouse eggs. (1987) (62)
- Intracytoplasmic sperm injection (ICSI) in 2006: evidence and evolution. (2007) (62)
- Fertilization promoting peptide, a tripeptide similar to thyrotrophin-releasing hormone, stimulates the capacitation and fertilizing ability of human spermatozoa in vitro. (1996) (61)
- Sperm capacitation and the acrosome reaction. (1998) (60)
- A possible mechanism of action for fertilization promoting peptide, a TRH‐related tripeptide that promotes capacitation and fertilizing ability in mammalian spermatozoa (1996) (58)
- In vitro capacitation and fertilization. (1993) (58)
- Cyclic nucleotide metabolism in mouse epididymal spermatozoa during capacitation in vitro (1984) (55)
- Na(+)-requiring mechanisms modulate capacitation and acrosomal exocytosis in mouse spermatozoa. (1993) (55)
- Both fertilization promoting peptide and adenosine stimulate capacitation but inhibit spontaneous acrosome loss in ejaculated boar spermatozoa in vitro (2000) (52)
- Modulation of adenylyl cyclase by FPP and adenosine involves stimulatory and inhibitory adenosine receptors and g proteins (1999) (51)
- Divalent cations, capacitation and the acrosome reaction in human spermatozoa. (1989) (51)
- The acrosome reaction in human sperm from men of proven fertility. (1987) (51)
- Interactions between a decapacitation factor and mouse spermatozoa appear to involve fucose residues and a GPI‐anchored receptor (1998) (51)
- Mammalian sperm phosphodiesterases and their involvement in receptor‐mediated cell signaling important for capacitation (2005) (51)
- Calcium channels play a pivotal role in the sequence of ionic changes involved in initiation of mouse sperm acrosomal exocytosis (1993) (50)
- Mouse sperm capacitation assessed by kinetics and morphology of fertilization in vitro. (1983) (50)
- Diagnosis and management of the infertile couple: missing information. (2004) (50)
- Regulation of mammalian sperm capacitation by endogenous molecules. (2006) (49)
- TCP‐11, the product of a mouse t‐complex gene, plays a role in stimulation of capacitation and inhibition of the spontaneous acrosome reaction (1997) (48)
- A possible role for Ca(2+)-ATPase in human sperm capacitation. (1994) (47)
- Analysis of aneuploidy in first-cleavage mouse embryos fertilized in vitro and in vivo. (1979) (46)
- Role for Ca2+ channels in the signal transduction pathway leading to acrosomal exocytosis in human spermatozoa (1996) (46)
- Adenylate cyclase activity of mouse sperm during capacitation in vitro: effect of calcium and a GTP analogue. (1986) (46)
- A role for diacylglycerol in human sperm acrosomal exocytosis. (1996) (45)
- Cathine and norephedrine, both phenylpropanolamines, accelerate capacitation and then inhibit spontaneous acrosome loss. (2005) (44)
- Capacitation state‐dependent changes in adenosine receptors and their regulation of adenylyl cyclase/cAMP (2002) (44)
- Differing requirements for capacitation in vitro of mouse spermatozoa from two strains. (1977) (44)
- Adenosine and gpp(NH)p modulate mouse sperm adenylate cyclase (1986) (44)
- Rate of fertilization in vitro and subsequent nuclear development as a function of the post-ovulatory age of the mouse egg. (1979) (44)
- Calcium channel antagonists modulate the acrosome reaction but not capacitation in mouse spermatozoa. (1989) (44)
- Consensus workshop on advanced diagnostic andrology techniques. ESHRE Andrology Special Interest Group. (1997) (44)
- Increased incidence of triploidy in embryos derived from mouse eggs fertilised in vitro (1976) (42)
- Maternal age and the incidence of aneuploidy in first-cleavage mouse embryos. (1978) (42)
- Immunolocalization of multiple Gα subunits in mammalian spermatozoa and additional evidence for Gαs (2003) (41)
- First messenger regulation of capacitation via G protein-coupled mechanisms: a tale of serendipity and discovery. (2003) (41)
- In vitro fertilization of tubal rabbit ova partially or totally denuded of follicular cells. (1971) (40)
- The effect of sperm and egg genotype on the incidence of chromosomal anomalies in mouse embryos fertilized in vitro. (1978) (40)
- New insights into the t‐complex and control of sperm function (1999) (40)
- First messenger regulation of mammalian sperm function via adenylyl cyclase/cAMP. (2005) (37)
- Cellular biology of capacitation and the acrosome reaction. (1995) (37)
- A biphasic pattern of 45Ca2+ uptake by mouse spermatozoa in vitro correlates with changing functional potential. (1993) (36)
- Identification of functional α2- and β-adrenergic receptors in mammalian spermatozoa (2006) (36)
- The effect of Mycoplasma pulmonis on fertilization and preimplantation development in vitro of mouse eggs. (1977) (36)
- Mouse sperm genotype and the rate of egg penetration in vitro. (1976) (35)
- Human oocyte-cumulus complexes stimulate the human acrosome reaction. (1989) (35)
- Cyclic nucleotides and mammalian sperm capacitation. (1990) (35)
- Fertilization promoting peptide and adenosine, acting as first messengers, regulate cAMP production and consequent protein tyrosine phosphorylation in a capacitation‐dependent manner (2000) (34)
- Effect of pentoxifylline and progesterone on human sperm capacitation and acrosomal exocytosis. (1994) (34)
- Murine cytomegalovirus and fertility: potential sexual transmission and the effect of this virus on fertilization in vitro. (1978) (33)
- Calcitonin, angiotensin II and FPP significantly modulate mouse sperm function. (2001) (33)
- Relationship between sperm concentration and the incidence of polyspermy in mouse embryos fertilized in vitro. (1978) (33)
- Adenosine and its analogues, possibly acting at A2 receptors, stimulate mouse sperm fertilizing ability during early stages of capacitation. (1990) (33)
- Physiopathological determinants of human infertility. (2002) (33)
- Protect us from poor-quality medical research. (2018) (33)
- Failures (with some successes) of assisted reproduction and gamete donation programs. (2013) (32)
- The effect of ruthenium red and concanavalin A on the vitelline surface of fertilized and unfertilized rabbit ova (1975) (31)
- FPP modulates mammalian sperm function via TCP‐11 and the adenylyl cyclase/cAMP pathway (1998) (30)
- Mono-ovulatory cycles: A key goal in profertility programmes (2003) (30)
- Both taurine and albumin support mouse sperm motility and fertilizing ability in vitro but there is no obligatory requirement for taurine. (1986) (29)
- Physico-chemical properties of an agent that induces parthenogenesis in Rana pipiens eggs. (1971) (29)
- Extended exposure to follicular fluid is required for significant stimulation of the acrosome reaction in human spermatozoa. (1989) (28)
- Requirements for successful mammalian sperm capacitation and fertilization. (1992) (27)
- Ca(2+)-related changes in the mouse sperm capacitation state: a possible role for Ca(2+)-ATPase. (1992) (27)
- Human sperm responses to calcitonin, angiotensin II and fertilization-promoting peptide in prepared semen samples from normal donors and infertility patients. (2004) (26)
- A fertilization promoting peptide (FPP)‐related tripeptide competitively inhibits responses to FPP: A cause of male subfertility? (1997) (25)
- Calcitonin acts as a first messenger to regulate adenylyl cyclase/cAMP and mammalian sperm function (2003) (25)
- Fertilization promoting peptide--a possible regulator of sperm function in vivo. (2001) (23)
- Angiotensin II stimulates cAMP production and protein tyrosine phosphorylation in mouse spermatozoa. (2004) (22)
- Capacitation- and fertilization-related alterations in mouse sperm oxygen consumption. (1987) (22)
- Molecular mechanisms during sperm capacitation (2005) (22)
- Acrosome loss in human sperm incubated in vitro under capacitating conditions. (1985) (21)
- Phosphodiesterase activity of mouse sperm incubated under conditions that modulate fertilizing potential in vitro. (1987) (20)
- Mechanisms controlling mammalian fertilization. (1984) (20)
- The effects of aging on in vitro fertilization of rabbit eggs and subsequent embryonic development. (1973) (20)
- Loss of cortical granules in rabbit eggs exposed to spermatozoa in vitro. (1972) (20)
- The role of small molecules in sperm capacitation. (2008) (19)
- Na+ requirements for capacitation and acrosomal exocytosis in mammalian sperm. (1994) (18)
- Fertilization and preimplantation development in vitro of mouse eggs obtained following stimulation with different doses of pregnant mare serum: a comparison of the responses in two strains. (1977) (18)
- Birth defects and congenital health risks in children conceived through assisted reproduction technology (ART): a meeting report (2014) (17)
- Enzymes of adenosine metabolism in mouse sperm suspensions. (1988) (15)
- Identification of functional alpha2- and beta-adrenergic receptors in mammalian spermatozoa. (2006) (15)
- Effect of removal of epididymal secretions on fertilization in vitro of mouse eggs. (1976) (14)
- Cathine, an amphetamine-related compound, acts on mammalian spermatozoa via beta1- and alpha2A-adrenergic receptors in a capacitation state-dependent manner. (2006) (14)
- New insights into possible causes of male infertility. (1999) (14)
- Inhibition of adenosine-metabolizing enzymes modulates mouse sperm fertilizing ability: a changing role for endogenously generated adenosine during capacitation. (1988) (14)
- Mechanisms of action of angiotensin II on mammalian sperm function. (2005) (13)
- Fertilization promoting peptide: an important regulator of sperm function in vivo? (1998) (13)
- Immunolocalization of multiple Galpha subunits in mammalian spermatozoa and additional evidence for Galphas. (2003) (13)
- Role of fertilization promoting peptide (FPP) in modulating mammalian sperm function. (1998) (10)
- Incidence of polyspermy in mouse eggs fertilized in vivo and in vitro after administration of progesterone and oestradiol. (1979) (10)
- The relationship between zona digestion and cortical granule disappearance in rabbit eggs inseminated in vitro. (1975) (10)
- Fertilization of rabbit eggs in vitro without supplemental CO 2 in the atmosphere. (1973) (10)
- Prolonged microvascular vasodilation induced by leukotriene B4 in human skin is cyclooxygenase independent. (1995) (9)
- A comparison of in-vitro fertilization of rabbit eggs using spermatozoa recovered from the uterus or vagina. (1976) (9)
- Fertilization--calcium-dependent events. (1996) (7)
- Modulation of mammalian sperm function by fertilization promoting peptide (FPP) (2009) (7)
- Protein Kinase C and Exocytosis in Mammalian Spermatozoa (1998) (6)
- The influence of social factors on gender health. (2016) (6)
- The potential impact of novel investigational compounds on human fertility (2006) (5)
- ART: boon or bane? (2002) (4)
- Environmental estrogens and sperm function. (2004) (4)
- Chromosomal analysis of rabbits derived from eggs fertilized in vitro. (1975) (3)
- New insights into possible factors contributing to male subfertility (2005) (3)
- Case report: Percutaneous electrical neural field stimulation in two cases of sympathetically-mediated pain (2017) (3)
- Purification of a mouse sperm decapacitation factor and its receptor (2000) (2)
- A comparison of fertility in vitro and in vivo after exposure of male mice to high environmental pressure (1986) (2)
- O-080. TCP-11, the product of a mouse t -complex gene, modulates sperm capacitation and fertilizing ability (1997) (2)
- O-078. A peptide related to fertilization-promoting peptide (FPP) can inhibit FPP's stimulation of capacitation: a possible cause of male subfertility? (1997) (1)
- Double publication in Human Reproduction Volume 15, Supplement 1, 2000. (2001) (1)
- Sperm morphology: does it have predictive value for in vitro fertilization? (1993) (1)
- VITAMINS AND HORMONES - ADVANCES IN RESEARCH AND APPLICATIONS, VOL 63 (2001) (1)
- Fertilisation Promoting Peptide: a key player in male fertility/subfertility? (1997) (1)
- O-021. Modulation of mammalian sperm adenylyl cyclase by FPP and adenosine involves first stimulatory and then inhibitory adenosine receptors and G proteins (1999) (0)
- Early human development in pictures Jan E Jirásek An Atl (2001) (0)
- Proceedings of the Ninth International Symposium on Cells of the Hepatic Sinusoid, Christchurch, New Zealand, September 27 - October 1, 1998 (1999) (0)
- Effect of bacterial neuraminidase on the fertilization of rabbit eggs in vitro. (1976) (0)
- Cell messengers at fertilization. Proceedings of a symposium of the British Society for Developmental Biology and the Society for the Study of Fertility held at the University of Warwick, December 1989. (1990) (0)
- Fertilization: by Frank J. Longo, Chapman and Hall, 1987. £9.95 (viii + 183 pages) ISBN 0 412 26410 2 (1988) (0)
- Oncologic, Endocrine & Metabolic Fertilization promoting peptide: a key player in male fertility/subfertility? (1997) (0)
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