Lawrence S. Kaminsky
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Molecular Biology
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Why Is Lawrence S. Kaminsky Influential?
(Suggest an Edit or Addition)Lawrence S. Kaminsky's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Cytochrome P450 (1993) (1119)
- Purification and characterization of liver microsomal cytochromes p-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone. (1982) (924)
- Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. (2003) (810)
- Human P450 metabolism of warfarin. (1997) (746)
- The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism. (1996) (641)
- Characterization of human small intestinal cytochromes P-450. (1999) (358)
- Human cytochromes P450 (1999) (303)
- 17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1A1: a comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA. (1992) (245)
- The small intestine as a xenobiotic-metabolizing organ. (2003) (230)
- Small intestinal cytochromes P450. (1991) (222)
- Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae. (1990) (205)
- Expression of cytochromes P450 in human breast tissue and tumors. (1996) (195)
- Purification and characterization of six cytochrome P-450 isozymes from human liver microsomes. (1983) (190)
- Optimization of Dnase I removal of contaminating DNA from RNA for use in quantitative RNA-PCR. (1996) (184)
- Characterization of purified human recombinant cytochrome P4501A1-Ile462 and -Val462: assessment of a role for the rare allele in carcinogenesis. (1996) (159)
- Fluoride: benefits and risks of exposure. (1990) (150)
- Purification and characterization of microsomal cytochrome P-450s. (1982) (148)
- Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probe. (1993) (144)
- Metabolic characterization of the major human small intestinal cytochrome p450s. (2001) (142)
- Effect of metals on polycyclic aromatic hydrocarbon induction of CYP1A1 and CYP1A2 in human hepatocyte cultures. (2001) (129)
- Polycyclic aromatic hydrocarbon/metal mixtures: effect on PAH induction of CYP1A1 in human HEPG2 cells. (2001) (125)
- Regulation of cytochrome P-450. Immunochemical quantitation of eight isozymes in liver microsomes of rats treated with polybrominated biphenyl congeners. (1983) (122)
- Calculation of 2,3,7,8-TCDD equivalent concentrations of complex environmental contaminant mixtures (1986) (120)
- Metabolism of dichlorobiphenyls by highly purified isozymes of rat liver cytochrome P-450. (1981) (115)
- Correlations between polychlorinated biphenyl immunotoxicity, the aromatic hydrocarbon locus, and liver microsomal enzyme induction in C57BL/6 and DBA/2 mice. (1984) (113)
- Characterization of human cytochromes P450 involved in theophylline 8-hydroxylation. (1995) (113)
- Influence of cytochrome P 450 polymorphisms on drug therapies : Pharmacogenetic , pharmacoepigenetic and clinical aspects (2007) (111)
- Gene-Environment Interaction Signatures by Quantitative mRNA Profiling in Exfoliated Buccal Mucosal Cells (2004) (108)
- Characterization of rat small intestinal cytochrome P450 composition and inducibility. (1996) (108)
- Human cytochromes P4501A1 and P4501A2: R-warfarin metabolism as a probe. (1995) (97)
- Phase I and II carcinogen metabolism gene expression in human lung tissue and tumors. (2003) (97)
- Characterization of mouse small intestinal cytochrome P450 expression. (2003) (95)
- [16] Production and application of antibodies to rat liver cytochrome P-450 (1981) (91)
- Human cytochrome P-450 metabolism of retinals to retinoic acids. (2000) (88)
- CYP1B1 expression in human lung. (2001) (88)
- Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice. (2007) (86)
- Cytochrome P-450 isozyme/isozyme functional interactions and NADPH-cytochrome P-450 reductase concentrations as factors in microsomal metabolism of warfarin. (1985) (82)
- Induction of CYP1A1 and CYP1B1 in T-47D human breast cancer cells by benzo[a]pyrene is diminished by arsenite. (2002) (78)
- Biochemical applications of a quantitative high-pressure liquid chromatographic assay of warfarin and its metabolites. (1977) (77)
- Rat small intestinal cytochromes P450 probed by warfarin metabolism. (1993) (73)
- Comparison of different forms of purified cytochrome P-450 from rat liver by immunological inhibition of regio- and stereoselective metabolism of warfarin. (1980) (72)
- 16Alpha-hydroxylation of estrone by human cytochrome P4503A4/5. (1998) (69)
- Comparison of monooxygenase activities and cytochrome P-450 isozyme concentrations in human liver microsomes. (1986) (69)
- Biotransformation of coumarin by rodent and human cytochromes P-450: metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice. (1999) (68)
- Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites. (2008) (67)
- Induction of hepatic microsomal cytochrome P-450 by mirex and kepone. (1978) (65)
- Influence of aging and induction of rat liver and kidney microsomal mixed function oxidase systems. (1980) (65)
- Transgenic Mice with a Hypomorphic NADPH-Cytochrome P450 Reductase Gene: Effects on Development, Reproduction, and Microsomal Cytochrome P450 (2005) (64)
- Regulation of cytochrome P4501A1 expression in rat small intestine. (1997) (64)
- The molecular epidemiology of lung cancer. (1997) (62)
- Thermodynamic studies of the opening of the heme crevice of ferricytochrome c. (1973) (62)
- Regioselective and stereoselective hydroxylation of R and S warfarin by different forms of purified cytochrome P-450 from rabbit liver. (1978) (62)
- Quantitative RNA-polymerase chain reaction-DNA analysis by capillary electrophoresis and laser-induced fluorescence. (1995) (61)
- Evidence for functional and structural multiplicity of pregnenolone-16 alpha-carbonitrile-inducible cytochrome P-450 isozymes in rat liver microsomes. (1987) (59)
- Human hepatic cytochrome P-450 composition as probed by in vitro microsomal metabolism of warfarin. (1984) (57)
- Inhibition of estrone sulfatase in human liver microsomes by quercetin and other flavonoids (1997) (57)
- Identification of Cytochrome P450 Oxidoreductase Gene Variants That Are Significantly Associated with the Interindividual Variations in Warfarin Maintenance Dose (2011) (53)
- An Intestinal Epithelium-Specific Cytochrome P450 (P450) Reductase-Knockout Mouse Model: Direct Evidence for a Role of Intestinal P450s in First-Pass Clearance of Oral Nifedipine (2009) (51)
- Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity. (1994) (48)
- Role of Small Intestinal Cytochromes P450 in the Bioavailability of Oral Nifedipine (2007) (46)
- Comparisons of warfarin metabolism by liver microsomes of rats treated with a series of polybrominated biphenyl congeners and by the component-purified cytochrome P-450 isozymes. (1983) (45)
- Metabolism of dichlorobiphenyls by hepatic microsomal cytochrome P-450. (1980) (44)
- Characterization of the cytochrome P450 CYP2J4: expression in rat small intestine and role in retinoic acid biotransformation from retinal. (1998) (44)
- A Novel Method for the Quantitation of Warfarin and its Metabolites in Plasma (1979) (43)
- Isozyme selectivity of the inhibition of rat liver cytochromes P-450 by chloramphenicol in vivo. (1985) (42)
- Alternative splicing of CYP2D mRNA in human breast tissue. (1997) (42)
- Comparison of different forms of liver, kidney, and lung microsomal cytochrome P-450 by immunological inhibition of regio- and stereoselective metabolism of warfarin. (1979) (42)
- Subchronic oral toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the guinea pig: comparisons with a PCB-containing transformer fluid pyrolysate. (1986) (40)
- CDNA cloning, heterologous expression, and characterization of rat intestinal CYP2J4. (1997) (40)
- Acute toxicity in guinea pigs and rabbits of soot from a polychlorinated biphenyl-containing transformer fire. (1982) (39)
- Cholesterol uptake by egg-yolk phosphatidylcholine. (1971) (39)
- Methionine sulfoxide cytochrome c. (1976) (37)
- Cumene hydroperoxide-supported microsomal hydroxylations of warfarin--a probe of cytochrome P-450 multiplicity and specificity. (1979) (37)
- Selective inhibition of warfarin metabolism by diltiazem in humans. (1991) (37)
- Fluroxene (2,2,2-trifluoroethyl vinyl ether) mediated destruction of cytochrome P-450 in vitro. (1975) (36)
- A new warfarin metabolite: structure and function. (1978) (36)
- Phase II metabolism of warfarin in primary culture of adult rat hepatocytes. (1992) (36)
- MECHANISMS OF ARSENITE-MEDIATED DECREASES IN BENZO[K]FLUORANTHENE-INDUCED HUMAN CYTOCHROME P4501A1 LEVELS IN HEPG2 CELLS (2005) (35)
- The role of cytochrome P-450 in the toxicity of fluroxene (2,2,2-trifluoroethyl vinyl ether) anaesthesia in vivo. (1976) (34)
- Composition of cytochrome P-450 isozymes from hepatic microsomes of C57BL/6 and DBA/2 mice assessed by warfarin metabolism, immunoinhibition, and immunoelectrophoresis with anti-(rat cytochrome P-450). (1984) (33)
- Dichloromethyl compounds as mechanism-based inactivators of rat liver cytochromes P-450 in vitro. (1986) (32)
- Teratology of 2,3,7,8-tetrachlorodibenzo-p-dioxin in a complex environmental mixture from the love canal. (1989) (32)
- Induction of mouse CYP2J by pyrazole in the eye, kidney, liver, lung, olfactory mucosa, and small intestine, but not in the heart. (2000) (32)
- A complex of cardiac cytochrome c1 and cytochrome c. (1976) (29)
- Determination of theophylline and its metabolites in rat liver microsomes and human urine by capillary electrophoresis. (1995) (29)
- Acute toxicity of fluorinated ether anesthetics: role of 2,2,2-trifluoroethanol and other metabolites. (1983) (29)
- Circular dichroism studies of the perturbations of cytochrome c by alcohols. (1972) (29)
- Chemical and biological investigations of a transformer accident at Binghamton, NY (1985) (29)
- Further investigations of the metabolism of fluroxene and the degradation of cytochromes P-450 in vitro. (1977) (28)
- Iron ligands in different forms of ferricytochrome c: the 620-nm band as a probe. (1972) (28)
- Comparisons of CYP2D messenger RNA splice variant profiles in human lung tumors and normal tissues. (1997) (27)
- Some properties of mammalian cardiac cytochrome c1. (1975) (27)
- Cytochromes P450 and cancer. (1999) (26)
- Warfarin as a probe of cytochromes P-450 function. (1989) (25)
- Effect of alcohols on the rate of autoxidation of ferrocytochrome c. (1971) (24)
- Intracellular lactate dehydrogenase concentration as an index of cytotoxicity in rat hepatocyte primary culture (1988) (24)
- Production and application of antibodies to rat liver cytochrome P-450. (1981) (24)
- Analysis of oxidative warfarin metabolites by thermospray high-performance liquid chromatography/mass spectrometry. (1989) (24)
- Caffeine based measures of CYP1A2 activity correlate with oral clearance of tacrine in patients with Alzheimer's disease. (1998) (24)
- Plasma and cellular markers of 3′‐azido‐3′‐dideoxythymidine (AZT) metabolism as indicators of DNA damage in cord blood mononuclear cells from infants receiving prepartum NRTIs (2007) (23)
- The interaction of hepatic microsomal cytochrome P-450 with fluroxene (2,2,2-trifluoroethyl vinyl ether) in vitro. (1976) (23)
- Subchronic exposure of mice to Love Canal soil contaminants. (1984) (22)
- Effects of organic solvents on the spectrum of cytochrome C. (1969) (22)
- Induction of CYP1A by benzo[k]fluoranthene in human hepatocytes: CYP1A1 or CYP1A2? (2001) (21)
- The role of cytochrome P-450-inducing agents in potentiaing the toxicity of fluroxene (2,2,2-trifluoroethyl vinyl ether). (1980) (20)
- Induction of CYP1A1 by beta-naphthoflavone in IEC-18 rat intestinal epithelial cells and potentiation of induction by dibutyryl cAMP. (1997) (20)
- Regioselective hydroxylation of warfarin by cell suspension cultures of Catharanthus roseus (1993) (20)
- Quantitation of CYP1A1 and 1B1 mRNA in polycyclic aromatic hydrocarbon-treated human T-47D and HepG2 cells by a modified bDNA assay using fluorescence detection. (2003) (20)
- The effects of Love Canal soil extracts on maternal health and fetal development in rats. (1986) (20)
- High abundance of testosterone and salivary androgen-binding protein in the lateral nasal gland of male mice (2009) (19)
- Destruction of highly purified cytochromes P-450 associated with metabolism of fluorinated ether anesthetics. (1981) (18)
- The Role of Trace Metals in Cytochrome P4501 Regulation (2006) (18)
- Investigations of the posttranslational mechanism of arsenite‐mediated downregulation of human cytochrome P4501A1 levels: The role of heme oxygenase‐1 (2009) (18)
- Detergents as probes of reconstituted rat liver cytochrome P-450 function. (1987) (18)
- Induction of rat small intestinal cytochrome P-450 2J4. (1999) (17)
- 16 α-Hydroxylation of estrone by human cytochrome P 4503 A 4 / 5 (1998) (17)
- Warfarin analog inhibition of human CYP2C9-catalyzed S-warfarin 7-hydroxylation. (1997) (17)
- A complex of cytochrome c and mixed mitochondrial phospholipids. (1973) (17)
- Fluorescence studies of cytochrome c1 and a cytochrome c1-cytochrome c complex. (1974) (16)
- CYP 1 B 1 EXPRESSION IN HUMAN LUNG (2001) (15)
- Metabolism of 2,2,2-trifluoroethanol and its relationship to toxicity. (1987) (15)
- Potentiation of fluroxene (2,2,2-trifluoroethyl vinyl ether) toxicity with polychlorinated biphenyls. (1979) (14)
- Selective inactivation by chlorofluoroacetamides of the major phenobarbital-inducible form(s) of rat liver cytochrome P-450. (1990) (14)
- Subchronic oral toxicity in guinea pigs of soot from a polychlorinated biphenyl-containing transformer fire. (1983) (14)
- High-performance liquid chromatography of polychlorinated biphenyls (1978) (14)
- Rat liver metabolism and toxicity of 2,2,2-trifluoroethanol. (1992) (14)
- Differences in the functional interaction of two purified cytochrome P-450 isozymes with epoxide hydrolase. (1981) (14)
- Effects of differential changes in rat hepatic and renal cytochrome P-450 concentrations on hepatotoxicity and nephrotoxicity of chloroform. (1981) (13)
- Carbon monoxide as a probe for conformation changes of ferrocytochrome c. (1972) (13)
- Azidowarfarin photoaffinity probes of purified rat liver cytochrome P4501A1. (1992) (12)
- 2,2,2-Trifluoroethanol intestinal and bone marrow toxicity: the role of its metabolism to 2,2,2-trifluoroacetaldehyde and trifluoroacetic acid. (1988) (12)
- Binding of R and S warfarin to hepatic microsomal cytochrome P-450. (1977) (11)
- Some properties of a cytochrome c-mixed mitochondrial phospholipid complex. (1974) (11)
- POLYCYCLIC AROMATIC HYDROCARBON / METAL MIXTURES : EFFECT ON PAH INDUCTION OF CYP 1 A 1 IN HUMAN HEPG 2 CELLS (2001) (11)
- Trifluorinated ether anesthetic lethality in rats: the role of bacterial infection. (1983) (10)
- Nitrones. Part III. Photolysis of cyclic nitrones (1966) (10)
- Fluorescence studies of a cytochrome C mixed phospholipid complex. (1973) (10)
- Some properties of particles of egg-yolk phosphatidylcholine and cholesterol (1972) (9)
- Role of hepatic microsomal cytochrome P-450 in the toxicity of fluorinated ether anesthetics. (1980) (9)
- Effect of chloramphenicol administration in vivo on cytochrome P-450-dependent monooxygenase activities in liver microsomes from uninduced male rats. (1988) (8)
- Determination of Metabolic Rates and Enzyme Kinetics (2007) (8)
- Nitrones. Part VI. The pyrolysis of oxaziridines derived by photolysis of cyclic nitrones (1967) (8)
- INDUCTION OF CYP 1 A 1 AND CYP 1 B 1 IN T-47 D HUMAN BREAST CANCER CELLS BY BENZO [ A ] PYRENE IS DIMINISHED BY ARSENITE (2002) (8)
- Molecular orbital studies of epoxide stability of carcinogenic polycyclic aromatic hydrocarbon diol epoxides. (1982) (8)
- Effects of organic solvents on cytochrome c (1969) (7)
- The photosynthesis of a 2-methyl-1-pyrroline 1-oxide (1965) (7)
- Mechanism of toxicity of 2,2,2-trifluoroethanol in rats. (1986) (7)
- Metabolism of monochlorobiphenyls by hepatic microsomal cytochrome P-450. (1980) (7)
- Fluroxene (2, 2, 2 ‐ Trifluoroethyl Vinyl Ether) Toxicity: A Chemical Aspect (1976) (7)
- A thermodynamic comparison of some oxidations of ferrocytochrome C (1971) (6)
- REGULATION OF CYTOCHROME P 4501 A 1 EXPRESSION IN RAT SMALL INTESTINE (1997) (6)
- Multiple aspects of the toxicity of fluroxene and its metabolite 2,2,2-trifluoroethanol. (1988) (6)
- 2,2,2-Trifluoroethanol-Induced Enteropathy in Rats: Chemically or Bacterially Mediated Effects (1987) (5)
- Nitrones. Part VIII. The ultraviolet absorption of the 1-pyrroline 1-oxides (1968) (5)
- The role of environmental matrices and experimental vehicles in chlorinated dibenzodioxin and dibenzofuran toxicity (1985) (5)
- Fluorescence probing of the function-specific cysteines of rat microsomal NADPH-cytochrome P-450 reductase. (1986) (5)
- Molecular orbital studies of the metabolism of fluroxene and analogous fluorinated ether anesthetics. (1981) (5)
- Development of the hepatic mixed-function oxidase system and its metabolism of warfarin in the perinatal rat. (1981) (4)
- Applications of theoretical chemistry in the prediction of metabolism (1983) (4)
- An investigation into the hepatic cytochrome P-450 catalysed metabolism of the anaesthetic fluroxene (2,2,2-trifluoroethyl vinyl ether). (1975) (4)
- Thermodynamic aspects of cytochrome c function. (1971) (3)
- An Intestinal Epithelium-Specific Cytochrome P450 Reductase-Knockout Mouse Model: Direct Evidence for A Role of Intestinal Cytochromes P450 in First-pass Clearance of Oral Nifedipine (2008) (3)
- A reversal of heme crevice strengths of ferri- and ferrocytochrome c on carboxymethylation. (1972) (3)
- Nitrones. Part V. The reaction of a cyclic nitrone with diethyl malonate (1967) (3)
- The ascorbate reduction of denatured ferricytochrome c. (1972) (3)
- Cytochrome P450 mRNA induction: quantitation by RNA-polymerase chain reaction using capillary electrophoresis. (1996) (3)
- The reactivity of conformationally modified cytochrome c. (1974) (2)
- Toxicology of atmospheric degradation products of selected hydrochlorofluorocarbons (1990) (2)
- 2,2,2-Trifluoroethanol Toxicity in Aged Rats (1988) (2)
- DIFFERENCES IN THE INTERACTIONS OF R AND S WARFARIN WITH HEPATIC MICROSOMAL CYTOCHROME P-450 (1977) (2)
- Synthesis of four tritium‐labelled aminowarfarin methyl ketal regioisomers (1992) (2)
- The emulsifying properties of egg yolk phosphatidylcholine (1972) (2)
- Fluoride: benefits and risks of exposure. The preparation of a report. (1992) (2)
- METABOLISM OF FLUROXENE AND ANALOGOUS FLUORINATED ETHER ANESTHETICS BY HIGHLY PURIFIED CYTOCHROMES P-450 AND THE ASSOCIATED ENZYME DESTRUCTION (1980) (1)
- 2,2,2-Trifluoroethanol Toxicity in Hamsters (Mesocricetus auratus) (1987) (1)
- WARFARIN METABOLISM - A PROBE OF PURIFIED RAT LIVER CYTOCHROMES P-450 (1980) (1)
- 8 – Chemical Alterations of Volatile Anesthetic Agent-Induced Hepato- and Nephrotoxicity (1990) (1)
- Cytochrome P450: Probes of Active Site Residues (1993) (0)
- FURTHER STUDIES OF THE FLUROXENE MEDIATED DESTRUCTION OF HEPATIC MICROSOMAL CYTOCHROMES P-450 IN VITRO (1977) (0)
- A NEW WARFARIN METABOLITE- STRUCTURE AND FUNCTION (1979) (0)
- THE DEVELOPMENT OF HEPATIC MIXED-FUNCTION OXIDASES - WARFARIN METABOLISM AS A PROBE (1980) (0)
- The autoxidation of cytochrome c: alcohols as possible models for the hydrophobic mitochondrial environment. (1971) (0)
- XII. BIOLOGICAL AND HEALTH EFFECTS (2012) (0)
- Substrate specificities and stereoselectivities of 7 purified isozymes of rat liver cytochrome p 450 (1982) (0)
- Activation of DNA Damage Signaling Components by Diagnostic Computed Tomography (CT) Scans Detected in Patient Samples Using an Electrochemiluminescence-Based Assay Platform (2017) (0)
- Selective inhibition by chloramphenicol of pregnenolone-16. cap alpha. -carbonitrile-inducible rat liver cytochrome P-450 isozymes (1986) (0)
- Azidowarfarin as photoaffinity probe of cytochromes P450. (1991) (0)
- 1495 – POTENTIATION OF FLUROXENE TOXICITY BY POLYCHLORINATED BIPHENYL INDUCED CYTOCHROME P-450 (1978) (0)
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