Lalita Ramakrishnan
American microbiologist
Lalita Ramakrishnan's AcademicInfluence.com Rankings
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Biology
Lalita Ramakrishnan's Degrees
- PhD Microbiology University of California, Berkeley
- Doctorate Medicine University of California, San Francisco
Why Is Lalita Ramakrishnan Influential?
(Suggest an Edit or Addition)According to Wikipedia, Lalita Ramakrishnan is an Indian-born American microbiologist who is known for her contributions to the understanding of the biological mechanism of tuberculosis. she serves as a professor of Immunology and Infectious Diseases at the University of Cambridge, where she is also a Wellcome Trust Principal Research Fellow and a practicing physician. Her research is conducted at the MRC Laboratory of Molecular Biology , where she serves as the Head of the Molecular Immunity Unit of the Department of Medicine embedded at the MRC LMB. Working with Stanley Falkow at Stanford, she developed the strategy of using Mycobacterium marinum infection as a model for tuberculosis. Her work has appeared in a number of journals, including Science, Nature, and Cell. In 2018 and 2019 Ramakrishnan coauthored two influential papers in the British Medical Journal arguing that the widely accepted estimates of the prevalence of latent tuberculosis—estimates used as a basis for allocation of research funds—are far too high. She is married to Mark Troll, a physical chemist.
Lalita Ramakrishnan's Published Works
Published Works
- The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection (2009) (809)
- Revisiting the role of the granuloma in tuberculosis (2012) (684)
- Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos. (2002) (531)
- Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis. (2008) (519)
- Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections (2012) (515)
- TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species (2013) (482)
- The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans (2010) (482)
- Granuloma-specific expression of Mycobacterium virulence proteins from the glycine-rich PE-PGRS family. (2000) (434)
- Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium (2010) (425)
- The secret lives of the pathogenic mycobacteria. (2003) (410)
- Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids (2013) (382)
- Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death. (2008) (325)
- Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism (2011) (317)
- Tuberculous Granuloma Formation Is Enhanced by a Mycobacterium Virulence Determinant (2004) (314)
- Host Evasion and Exploitation Schemes of Mycobacterium tuberculosis (2014) (312)
- Mycobacterium marinum Infection of Adult Zebrafish Causes Caseating Granulomatous Tuberculosis and Is Moderated by Adaptive Immunity (2006) (303)
- Applications for green fluorescent protein (GFP) in the study of host-pathogen interactions. (1996) (294)
- Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis (2008) (278)
- Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism (2011) (264)
- Neutrophils exert protection in the early tuberculous granuloma by oxidative killing of mycobacteria phagocytosed from infected macrophages. (2012) (262)
- Guidelines for morpholino use in zebrafish (2017) (240)
- Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish. (2007) (238)
- Revisiting the timetable of tuberculosis (2018) (234)
- Why Is Long-Term Therapy Required to Cure Tuberculosis? (2007) (197)
- The Formation and Function of Granulomas. (2018) (187)
- Superinfecting mycobacteria home to established tuberculous granulomas (2004) (179)
- Evaluation of the pathogenesis and treatment of Mycobacterium marinum infection in zebrafish (2013) (176)
- Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions (2017) (175)
- Mycobacterium marinum persists in cultured mammalian cells in a temperature-restricted fashion (1994) (144)
- Pseudomonas aeruginosa Type III secretion system interacts with phagocytes to modulate systemic infection of zebrafish embryos (2009) (126)
- Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. (2014) (116)
- Immunity and Immunopathology in the Tuberculous Granuloma. (2015) (114)
- Mycobacterium marinum causes both long-term subclinical infection and acute disease in the leopard frog (Rana pipiens) (1997) (114)
- Complex pattern of Mycobacterium marinum gene expression during long-term granulomatous infection (2002) (113)
- TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit (2019) (111)
- Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages (2017) (105)
- Dynamic Nature of Host-Pathogen Interactions inMycobacterium marinum Granulomas (2001) (98)
- Is Mycobacterium tuberculosis infection life long? (2019) (93)
- New models for the study of Mycobacterium-host interactions. (2004) (92)
- Mycobacterium marinum Erp Is a Virulence Determinant Required for Cell Wall Integrity and Intracellular Survival (2006) (91)
- Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment (2015) (90)
- Zebrafish and Frog Models of Mycobacterium marinum Infection (2006) (90)
- Insights into early mycobacterial pathogenesis from the zebrafish. (2008) (88)
- Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration (2016) (88)
- A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy (2017) (83)
- Remodeling schemes of intracellular pathogens. (1994) (82)
- Leukotriene A4 Hydrolase Genotype and HIV Infection Influence Intracerebral Inflammation and Survival From Tuberculous Meningitis (2017) (82)
- An in vivo platform for rapid high-throughput antitubercular drug discovery. (2012) (80)
- Antimicrobial efflux pumps and Mycobacterium tuberculosis drug tolerance: evolutionary considerations. (2013) (75)
- Mycobacterial Acid Tolerance Enables Phagolysosomal Survival and Establishment of Tuberculous Infection In Vivo (2016) (74)
- Do mycobacteria produce endospores? (2009) (74)
- Multiplex fluorescent in situ hybridization in zebrafish embryos using tyramide signal amplification. (2005) (73)
- Looking within the zebrafish to understand the tuberculous granuloma. (2013) (66)
- A crtB homolog essential for photochromogenicity in Mycobacterium marinum: isolation, characterization, and gene disruption via homologous recombination (1997) (66)
- The zebrafish guide to tuberculosis immunity and treatment. (2013) (60)
- Leptospira interrogans Stably Infects Zebrafish Embryos, Altering Phagocyte Behavior and Homing to Specific Tissues (2009) (56)
- Trafficking of superinfecting Mycobacterium organisms into established granulomas occurs in mammals and is independent of the Erp and ESX-1 mycobacterial virulence loci. (2008) (54)
- Insights into tuberculosis from the zebrafish model. (2012) (53)
- TB: the Yin and Yang of lipid mediators. (2013) (45)
- Studies in the Host-Parasite Relations of Blast Disease of Rice.: II. Changes in the Carbohydrates and Phenolics (1966) (42)
- An Enzyme That Inactivates the Inflammatory Mediator Leukotriene B4 Restricts Mycobacterial Infection (2013) (39)
- Latent Tuberculosis: Two Centuries of Confusion (2021) (37)
- Studies in the Host‐Parasite Relations of Blast Disease of Rice (1966) (34)
- Delay of Initial Feeding of Zebrafish Larvae Until 8 Days Postfertilization Has No Impact on Survival or Growth Through the Juvenile Stage (2018) (33)
- Using Mycobacterium marinum and its hosts to study tuberculosis (2004) (30)
- Schistosoma mansoni Eggs Modulate the Timing of Granuloma Formation to Promote Transmission (2020) (27)
- Mycobacterium tuberculosis pathogenicity viewed through the lens of molecular Koch's postulates. (2020) (26)
- "The very pulse of the machine": the tuberculous granuloma in motion. (2008) (24)
- A Zebrafish Model of Mycobacterium leprae Granulomatous Infection (2017) (24)
- BP-1/6C3 expression defines a differentiation stage of transformed pre-B cells and is not related to malignant potential. (1990) (24)
- Xpert MTB/RIF Ultra for the Diagnosis of Tuberculous Meningitis: A Small Step Forward (2020) (21)
- Applications of gene fusions to green fluorescent protein and flow cytometry to the study of bacterial gene expression in host cells. (2000) (21)
- Studies on Alternaria leaf spot of tomato. (1970) (19)
- A zebrafish model for ocular tuberculosis (2017) (18)
- Mycobacterium marinum phthiocerol dimycocerosates enhance macrophage phagosomal permeabilization and membrane damage (2020) (18)
- Changes in ribonucleic acids during uredospore differentiation. (1970) (17)
- Spotlight on Zebrafish: Translational Impact (2014) (17)
- "The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design" - Meeting report. (2017) (16)
- Novel B-cell precursors blocked at the stage of DJH recombination (1988) (15)
- Mycobacterium marinum Infection of Adult Zebrafish Causes Caseating Granulomatous Tuberculosis and Is Moderated by Adaptive Immunity (2007) (12)
- TNF induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport (2022) (11)
- A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival in tuberculous meningitis (2021) (10)
- Diverse Clinical Isolates of Mycobacterium tuberculosis Develop Macrophage-Induced Rifampin Tolerance (2019) (10)
- Elevated cerebrospinal fluid cytokine levels in tuberculous meningitis predict survival in response to dexamethasone (2020) (9)
- Incidence of whitefly transmitted viruses in Tamil Nadu. (1988) (8)
- mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity (2022) (8)
- The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence (2022) (7)
- The Acetobacteraceae: Extending the Spectrum of Human Pathogens (2006) (6)
- mTOR deficiency reveals an immunological trade-off in innate resistance to mycobacterial infection in vivo (2016) (5)
- Studies in the Host-Parasite Relations of Blast Disease of Rice.: III. The Effect of Night Temperature on the Infection Phase of Blast Disease (1966) (5)
- Membrane bound ribosomes in germinated uredospores. (1970) (5)
- Tumor Necrosis Factor and Schistosoma mansoni egg antigen omega-1 shape distinct aspects of the early egg-induced granulomatous response (2020) (5)
- Phenolic glycolipid facilitates mycobacterial escape from a microbicidal population of tissue-resident macrophages (2017) (5)
- Trafficking of Superinfecting Mycobacterium Organisms into Established Granulomas Occurs in Mammals and Is Independent of the Erp and ESX-1 Mycobacterial Virulence (2008) (4)
- Evidence for a template RNA in resting uredospores of the Bean rust fungus. (1970) (4)
- Antimicrobial efflux pumps and Mycobacterium tuberculosis drug tolerance (2013) (4)
- Pathogen strategies: A Hitchhiker's guide to the macrophage (1999) (3)
- Spotlight on Zebrafish: Translational Impact (2014) (3)
- SLeuthing Tuberculous Cough (2020) (2)
- TORmented macrophages spontaneously form granulomas (2017) (2)
- The Mycobacterium marinum RD1 locus promotes virulence and macrophage aggregation into tuberculous granulomas by enhancing induction of host matrix metalloproteinase 9 in proximal epithelial cells (133.19) (2009) (1)
- The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance (2023) (1)
- Study on economical weed management programme in young and pruned tea with oxyfluorfen. (1981) (1)
- An interview with Lalita Ramakrishnan. (2013) (1)
- Macrophage-induced rifampin tolerance across Mycobacterium tuberculosis lineages is Rv1258c-dependent (2018) (1)
- Effect of Storage on the Rate of Incorporation of Uridine into Ribonucleic Acid by Germinating Uredospores (1971) (1)
- mTOR-associated Mitochondrial Energy Metabolism Limits Mycobacterium ESX-1-induced Cytotoxicity (2022) (1)
- New models for the study of Mycobacterium–host interactions: [Curr. Opin. Immunol. 16 (2004) 499] (2005) (1)
- A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival probability of tuberculous meningitis patients treated with adjunctive dexamethasone (2020) (1)
- Evaluation of oxyfluorfen in pregerminated broadcast lowland rice in Sri Lanka (1983) (1)
- 445 MYCOBACTERIUM 19 KDA LIPOPROTEIN IS NOT REQUIRED FOR APOPTOSIS IN VIVO. (2006) (0)
- Innate immunity to tuberculosis: a forward genetic approach (133.15) (2009) (0)
- Author response: A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival in tuberculous meningitis (2020) (0)
- Macrophages and Infection Control (2014) (0)
- 2019 Computing Sciences Strategic Plan (2021) (0)
- Faculty Opinions recommendation of Cutting Edge: Regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis. (2007) (0)
- Tumor Necrosis Factor induces pathogenic programmed macrophage necrosis in tuberculosis through a mitochondrial-lysosomal-endoplasmic reticulum circuit (2019) (0)
- Faculty Opinions recommendation of Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase. (2009) (0)
- Gaucher disease protects against tuberculosis (2022) (0)
- The Zebrafish as a Model of Host-Pathogen Interactions (2009) (0)
- Cell Trafficking and Innate Immunity to Mycobacteria (2006) (0)
- The pro-apoptotic factor Bax regulates macrophage necrosis during Mycobacterial infection (2016) (0)
- Mycobacterium tuberculosis on the evolution of marinum Mycobacterium Insights from the complete genome sequence of Material Supplemental (2008) (0)
- Innate immunity to tuberculosis in zebrafish: roles of MMPs (2006) (0)
- 345 MODELING MYCOBACTERIUM TUBERCULOSIS INFECTION IN FISH AND FROGS. (2004) (0)
- Mechanism of M-CSF pathway-mediated innate resistance to tuberculosis (134.76) (2009) (0)
- Replenishment of granuloma macrophages promotes mycobacterial resistance by preventing extracellular bacterial growth (INC7P.410) (2014) (0)
- MODELING MYCOBACTERIUM TUBERCULOSIS INFECTION IN FISH AND FROGS.: 345 (2004) (0)
- 51 MYCOBACTERIUM 19 KDA LIPOPROTEIN IS NOT REQUIRED FOR APOPTOSIS IN VIVO. (2006) (0)
- Mycobacteria inhibit neutrophil recruitment to avoid neutrophil-assisted killing by macrophages (2020) (0)
- Ebselen inhibits mycobacterial ESX-1 secretion through modification of EccA1 (2019) (0)
- Redefining tuberculosis: an interview with Lalita Ramakrishnan (2023) (0)
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