Lars Thelander
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Swedish biochemist
Lars Thelander's AcademicInfluence.com Rankings
Lars Thelanderbiology Degrees
Biology
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Molecular Biology
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Biochemistry
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Biology
Lars Thelander's Degrees
- Masters Chemistry Uppsala University
- Bachelors Chemistry Uppsala University
Why Is Lars Thelander Influential?
(Suggest an Edit or Addition)According to Wikipedia, Lars Thelander, born 1942, is a Swedish biochemist. He was awarded a Ph.D. degree at the Karolinska Institutet in 1968. and is a professor of medical chemistry and biophysics at Umeå University. Thelander is a member of the Royal Swedish Academy of Sciences since 1994, a member of the Nobel Committee for Chemistry since 2006 and the Committees chairman since 2010.
Lars Thelander's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Reduction of ribonucleotides. (1979) (1028)
- Survival of DNA Damage in Yeast Directly Depends on Increased dNTP Levels Allowed by Relaxed Feedback Inhibition of Ribonucleotide Reductase (2003) (456)
- Inactivation of ribonucleotide reductase by nitric oxide. (1991) (351)
- Alterations of ribonucleotide reductase activity following induction of the nitrite-generating pathway in adenocarcinoma cells. (1990) (299)
- The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage (2001) (291)
- Cell cycle-dependent expression of mammalian ribonucleotide reductase. Differential regulation of the two subunits. (1985) (272)
- Regulation of Mammalian Ribonucleotide Reduction and dNTP Pools after DNA Damage and in Resting Cells* (2006) (271)
- Iron and free radical in ribonucleotide reductase. Exchange of iron and Mössbauer spectroscopy of the protein B2 subunit of the Escherichia coli enzyme. (1973) (266)
- ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEOTIDES.V. PURIFICATION AND PROPERTIES OF THIOREDOXIN REDUCTASE FROM ESCHERICHIA COLI B. (1964) (236)
- Cell cycle-dependent regulation of mammalian ribonucleotide reductase. The S phase-correlated increase in subunit M2 is regulated by de novo protein synthesis. (1984) (224)
- Mammalian p53R2 Protein Forms an Active Ribonucleotide Reductasein Vitro with the R1 Protein, Which Is Expressed Both in Resting Cells in Response to DNA Damage and in Proliferating Cells* (2001) (206)
- Role of ribonucleotide reductase in inhibition of mammalian cell growth by potent iron chelators. (1993) (186)
- Continual presence of oxygen and iron required for mammalian ribonucleotide reduction: possible regulation mechanism. (1983) (184)
- S-phase-specific expression of mammalian ribonucleotide reductase R1 and R2 subunit mRNAs. (1990) (178)
- Mouse ribonucleotide reductase R2 protein: A new target for anaphase-promoting complex-Cdh1-mediated proteolysis (2003) (173)
- Allosteric regulation of calf thymus ribonucleoside diphosphate reductase. (1979) (160)
- Yeast Sml1, a Protein Inhibitor of Ribonucleotide Reductase* (1999) (155)
- Cid13 Is a Cytoplasmic Poly(A) Polymerase that Regulates Ribonucleotide Reductase mRNA (2002) (145)
- Metabolic fate of oxidized guanine ribonucleotides in mammalian cells. (1999) (142)
- Ribonucleotide reductase from calf thymus. Purification and properties. (1979) (136)
- Isolation and characterization of expressible cDNA clones encoding the M1 and M2 subunits of mouse ribonucleotide reductase (1986) (130)
- Ribonucleoside diphosphate reductase. Purification of the two subunits, proteins B1 and B2. (1969) (126)
- Subunit M2 of mammalian ribonucleotide reductase. Characterization of a homogeneous protein isolated from M2-overproducing mouse cells. (1985) (126)
- Ribonucleotide reductase from calf thymus. Separation of the enzyme into two nonidentical subunits, proteins M1 and M2. (1980) (124)
- Physicochemical characterization of ribonucleoside diphosphate reductase from Escherichia coli. (1973) (123)
- Reduction and loss of the iron center in the reaction of the small subunit of mouse ribonucleotide reductase with hydroxyurea. (1993) (122)
- Rnr4p, a novel ribonucleotide reductase small-subunit protein (1997) (121)
- Characterization of the free radical of mammalian ribonucleotide reductase. (1982) (120)
- Purification and characterization of recombinant mouse and herpes simplex virus ribonucleotide reductase R2 subunit. (1991) (118)
- Mechanism of inhibition of mammalian ribonucleotide reductase by the iron chelate of 1-formylisoquinoline thiosemicarbazone. Destruction of the tyrosine free radical of the enzyme in an oxygen-requiring reaction. (1983) (115)
- The three-dimensional structure of mammalian ribonucleotide reductase protein R2 reveals a more-accessible iron-radical site than Escherichia coli R2. (1996) (109)
- Ribonucleotide reductase M1 subunit in cellular proliferation, quiescence, and differentiation. (1988) (108)
- Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage (2008) (106)
- Localization of ribonucleotide reductase in mammalian cells. (1984) (101)
- Overproduction of the free radical of ribonucleotide reductase in hydroxyurea-resistant mouse fibroblast 3T6 cells. (1981) (100)
- Mutational and Structural Analyses of the Ribonucleotide Reductase Inhibitor Sml1 Define Its Rnr1 Interaction Domain Whose Inactivation Allows Suppression of mec1 andrad53 Lethality (2000) (99)
- Yeast ribonucleotide reductase has a heterodimeric iron-radical-containing subunit. (2000) (99)
- Trypanosoma brucei CTP synthetase: A target for the treatment of African sleeping sickness (2001) (98)
- Magnetic interaction between the tyrosyl free radical and the antiferromagnetically coupled iron center in ribonucleotide reductase. (1987) (97)
- Active site of ribonucleoside diphosphate reductase from Escherichia coli. Inactivation of the enzyme by 2'-substituted ribonucleoside diphosphates. (1976) (96)
- Glutathione-dependent hydrogen donor system for calf thymus ribonucleoside-diphosphate reductase. (1979) (95)
- p53R2-dependent Ribonucleotide Reduction Provides Deoxyribonucleotides in Quiescent Human Fibroblasts in the Absence of Induced DNA Damage* (2007) (92)
- The Ribonucleotide Reductase R1 Homolog of Murine Cytomegalovirus Is Not a Functional Enzyme Subunit but Is Required for Pathogenesis (2004) (91)
- Spectrum and iron content of protein B2 from ribonucleoside diphosphate reductase. (1969) (91)
- S Phase-specific Transcription of the Mouse Ribonucleotide Reductase R2 Gene Requires Both a Proximal Repressive E2F-binding Site and an Upstream Promoter Activating Region* (2004) (90)
- Reaction mechanism of ribonucleoside diphosphate reductase from Escherichia coli. Oxidation-reduction-active disulfides in the B1 subunit. (1974) (89)
- Evidence by site-directed mutagenesis supports long-range electron transfer in mouse ribonucleotide reductase. (1995) (85)
- EPR stopped-flow studies of the reaction of the tyrosyl radical of protein R2 from ribonucleotide reductase with hydroxyurea. (1992) (82)
- Characterization of the active site of ribonucleotide reductase of Escherichia coli, bacteriophage T4 and mammalian cells by inhibition studies with hydroxyurea analogues. (1982) (78)
- Thioredoxin reductase. Characterization of a homogenous preparation from Escherichia coli B. (1967) (77)
- Yeast DNA Damage-inducible Rnr3 Has a Very Low Catalytic Activity Strongly Stimulated after the Formation of a Cross-talking Rnr1/Rnr3 Complex* (2002) (75)
- Induction of a new ribonucleotide reductase after infection of mouse L cells with pseudorabies virus (1982) (72)
- The Schizosaccharomyces pombe Replication Inhibitor Spd1 Regulates Ribonucleotide Reductase Activity and dNTPs by Binding to the Large Cdc22 Subunit* (2006) (70)
- Allosteric Regulation of Trypanosoma bruceiRibonucleotide Reductase Studied in Vitro and in Vivo * (1998) (69)
- Ribonucleotide reductase and mitochondrial DNA synthesis (2007) (62)
- [30] Ribonucleoside diphosphate reductase (Escherichia coli) (1978) (62)
- Cloning and characterization of the R1 and R2 subunits of ribonucleotide reductase from Trypanosoma brucei. (1997) (60)
- Evidence by Mutagenesis that Tyr370 of the Mouse Ribonucleotide Reductase R2 Protein Is the Connecting Link in the Intersubunit Radical Transfer Pathway* (1999) (60)
- Paracetamol inhibits replicative DNA synthesis and induces sister chromatid exchange and chromosomal aberrations by inhibition of ribonucleotide reductase. (1990) (54)
- Molecular mechanisms of drug resistance involving ribonucleotide reductase: hydroxyurea resistance in a series of clonally related mouse cell lines selected in the presence of increasing drug concentrations. (1988) (54)
- Tyrosyl free radical formation in the small subunit of mouse ribonucleotide reductase. (1990) (54)
- A kinetic study on the influence of nucleoside triphosphate effectors on subunit interaction in mouse ribonucleotide reductase. (1996) (51)
- Ribonucleotide reductase M2 subunit sequences mapped to four different chromosomal sites in humans and mice: functional locus identified by its amplification in hydroxyurea-resistant cell lines. (1987) (50)
- Enzymatic synthesis of deoxyribonucleotides, 8. The effects of ATP and dATP in the CDP reductase system from E. coli. (1965) (50)
- Purification, characterization, and localization of subunit interaction area of recombinant mouse ribonucleotide reductase R1 subunit. (1994) (49)
- Elevated expression of M1 and M2 components and drug-induced posttranscriptional modulation of ribonucleotide reductase in a hydroxyurea-resistant mouse cell line. (1987) (48)
- High Field EPR Studies of Mouse Ribonucleotide Reductase Indicate Hydrogen Bonding of the Tyrosyl Radical* (1996) (48)
- Expression of an Altered Ribonucleotide Reductase Activity Associated with the Replication of Murine Cytomegalovirus in Quiescent Fibroblasts (2000) (47)
- Role of a Proximal NF-Y Binding Promoter Element in S Phase-specific Expression of Mouse Ribonucleotide Reductase R2 Gene (*) (1995) (46)
- Induction of the Mouse Ribonucleotide Reductase R1 and R2 Genes in Response to DNA Damage by UV Light* (1996) (45)
- The TATA-less Promoter of Mouse Ribonucleotide Reductase R1 Gene Contains a TFII-I Binding Initiator Element Essential for Cell Cycle-regulated Transcription (*) (1995) (44)
- Expression, Purification, Characterization, and in Vivo Targeting of Trypanosome CTP Synthetase for Treatment of African Sleeping Sickness* (2007) (42)
- Molecular cloning and expression of the functional gene encoding the M2 subunit of mouse ribonucleotide reductase: a new dominant marker gene. (1989) (42)
- Structural proteins of adenoviruses. IX. Molecular weight and subunit composition of adenovirus type 2 fiber. (1973) (42)
- An S‐phase specific release from a transcriptional block regulates the expression of mouse ribonucleotide reductase R2 subunit. (1992) (41)
- The Iron-Oxygen Reconstitution Reaction in Protein R2-Tyr-177 Mutants of Mouse Ribonucleotide Reductase (1999) (39)
- Kinetic Evidence That a Radical Transfer Pathway in Protein R2 of Mouse Ribonucleotide Reductase Is Involved in Generation of the Tyrosyl Free Radical* (1998) (38)
- The structural gene for the M1 subunit of ribonucleotide reductase maps to chromosome 11, band p15, in human and to chromosome 7 in mouse. (1988) (37)
- EPR Studies of Mixed-Valent [FeIIFeIII] Clusters formed in the R2 Subunit of Ribonucleotide Reductase from Mouse or Herpes Simplex Virus: Mild Chemical Reduction of the Diferric Centers (1994) (37)
- 1H NMR studies of mouse ribonucleotide reductase: the R2 protein carboxyl-terminal tail, essential for subunit interaction, is highly flexible but becomes rigid in the presence of protein R1. (1994) (36)
- Structure and promoter characterization of the gene encoding the large subunit (R1 protein) of mouse ribonucleotide reductase. (1993) (36)
- Chlamydial ribonucleotide reductase: tyrosyl radical function in catalysis replaced by the FeIII-FeIV cluster. (2006) (33)
- Studies on thioredoxin reductase from Escherichia coli B. The relation of structure and function. (1968) (32)
- Ribonucleotide reductase in mammalian systems (1994) (29)
- The role of herpes simplex virus ribonucleotide reductase small subunit carboxyl terminus in subunit interaction and formation of iron-tyrosyl center structure. (1992) (29)
- DNA Building Blocks at the Foundation of Better Survival (2003) (29)
- Nonheme iron as a cofactor in ribonucleotide reductase from E. coli. (1968) (28)
- Ribonucleotide Reductase from Calf Thymus (2001) (24)
- Different cellular distribution of thioredoxin and subunit M1 of ribonucleotide reductase in rat tissues. (1986) (24)
- Ribonucleoside diphosphate reductase (Escherichia coli). (1978) (23)
- 5'-Phosphoramidates and 5'-diphosphates of 2'-O-allyl-beta-D-arabinofuranosyluracil, -cytosine, and -adenine: inhibition of ribonucleotide reductase. (1999) (19)
- 2'-Deoxy-2'-azidocytidine, a new inhibitor of DNA replication in mammalian cells. (1977) (18)
- EPR study of the mixed-valent diiron sites in mouse and herpes simplex virus ribonucleotide reductases. Effect of the tyrosyl radical on structure and reactivity of the diferric center. (1997) (17)
- Trypanosoma brucei Thymidine Kinase Is Tandem Protein Consisting of Two Homologous Parts, Which Together Enable Efficient Substrate Binding* (2012) (17)
- Molecular mechanisms responsible for the drug-induced posttranscriptional modulation of ribonucleotide reductase levels in a hydroxyurea-resistant mouse L cell line. (1988) (17)
- EPR studies on a stable sulfinyl radical observed in the iron-oxygen-reconstituted Y177F/I263C protein R2 double mutant of ribonucleotide reductase from mouse. (2002) (14)
- The amino acid sequence of a peptide containing the active center disulfide of thioredoxin reductase from Escherichia coli. (1971) (14)
- The Involvement of Arg265 of Mouse Ribonucleotide Reductase R2 Protein in Proton Transfer and Catalysis* (2006) (13)
- Demonstration of apolipoprotein CII in guinea pigs. Functional characteristics, cDNA sequence, and tissue expression. (1991) (13)
- Rat apolipoprotein C-II lacks the conserved site for proteolytic cleavage of the pro-form. (1991) (12)
- Allosteric regulation of calf thymus ribonucleotide reductase. (1978) (11)
- A mouse in vitro transcription system reconstituted from highly purified RNA polymerase II, TFIIH and recombinant TBP, TFIIB, TFIIE and TFIIF. (2001) (11)
- Formation of a free radical of the sulfenylimine type in the mouse ribonucleotide reductase reaction with 2'-azido-2'-deoxycytidine 5'-diphosphate. (1995) (11)
- Metal binding and activity of ribonucleotide reductase protein R2 mutants: conditions for formation of the mixed manganese-iron cofactor. (2009) (11)
- THE STEREOSPECIFICITY OF THIOREDOXIN REDUCTASE FOR TRIPHOSPHOPYRIDINE NUCLEOTIDE. (1965) (11)
- Kinetic studies on the reduction of the R2 subunit of mouse ribonucleotide reductase with hydroxyurea, hydrazine, phenylhydrazine and hydroxylamine (1997) (11)
- Mouse ribonucleotide reductase: from genes to proteins. (1995) (11)
- Herpes simplex virus ribonucleotide reductase: expression in Escherichia coli and purification to homogeneity of a tyrosyl free radical-containing, enzymatically active form of the 38-kilodalton subunit (1989) (10)
- Sequences downstream of the transcription initiation site are important for proper initiation and regulation of mouse ribonucleotide reductase R2 gene transcription. (2003) (9)
- Effects of x-ray irradiation on deoxyribonucleotide and DNA synthesis in cultured mouse embryo cells. (1971) (9)
- 2'-Deoxy-2'-azidocytidine inhibits the initiation of polyoma DNA synthesis. (1977) (9)
- EPR and multi-field magnetisation of reduced forms of the binuclear iron centre in ribonucleotide reductase from mouse (1996) (9)
- The critical C-terminus of the small subunit of herpes simplex virus ribonucleotide reductase is mobile and conformationally similar to C-terminal peptides. (2009) (8)
- De novo dNTP production is essential for normal postnatal murine heart development (2019) (7)
- Apolipoprotein CII from Chicken (Gallus domesticus) (1996) (7)
- Calf Thymus Ribonucleotide Reductase: Purification and Properties (1977) (6)
- Guinea pig apolipoprotein C-II: expression in E. coli, functional studies of recombinant wild-type and mutated variants, and distribution on plasma lipoproteins. (1997) (6)
- Gene structure and regulation of the expression of the R1 and R2 subunits of mouse ribonucleotide reductase. (1989) (5)
- Interaction between the tyrosyl free radical and the antiferromagnetic iron center in ribonucleotide reductase (1983) (4)
- Addendum: Amino Acid Composition of Thioredoxin Reductase from Escherichia coli B (1968) (2)
- Mechanism and control of ribonucleoside diphosphate reductase. (1977) (2)
- 10. Hydroxamic Acids and Other Hydroxylamine Derivatives as Inhibitors of DNA Synthesis (1982) (2)
- Synthesis, cytostatic activity and inhibition of ribonucleotide reductase by 5'-phosphoramidates and 5'-diphosphates, of 2'-O-allyl-arabinofuranosyl nucleosides. (1999) (2)
- The active site of ribonucleoside diphosphate reductase. (1977) (1)
- S phase-specific transcription of the mouse ribonucleotide reductase R2 gene is dependent on an upstream promoter activating region and a proximal repressive E2F binding site. (2003) (1)
- Amino acid composition of thioredoxin reductase from Escherichia coli B. (1968) (1)
- Chemical reduction of the diferric/radical center in protein R2 from mouse ribonucleotide reductase is independent of the proposed radical transfer pathway (2002) (1)
- Controlled protein degradation regulates ribonucleotide reductase activity in proliferating mammalian cells during the cell cycle (2000) (1)
- Demonstration of Apolipoprotein CII in Guinea Pigs (2001) (1)
- Drug for treatment of diseases caused by parasitic protozoa (2001) (0)
- Rapid kinetics of formation of the stable Y177∗ and a transient radical during reconstitution of mouse R2 protein (1995) (0)
- Cell Cycle-dependent Regulation of Mammalian Ribonucleotide (1984) (0)
- Characterization of the active state of chlamidial ribonucleotide reductase: tyrosyl radical functions replaced by FeIII-FeIV cluster (2005) (0)
- [Nucleic acid research--family history with two Nobel Prizes]. (2008) (0)
- Medication for the treatment of diseases caused by parasitic protozoa diseases (2001) (0)
- Paracetamol inhibits replicative DNA synthesis and induces sister-chromatid exchanges by destruction of a tyrosyl radical or ribonucleotide reductase (1990) (0)
- Cell Cycle-dependent Expression of Mammalian Ribonucleotide (1985) (0)
- Experience of ultraviolet curing on hardwood flooring. (1984) (0)
- PROTEIN R2 OF RIBONUCLEOTIDE REDUCTASE FROM MOUSE (1997) (0)
- Tyrosyl radical formation in the small subunit of mammalian ribonucleotide reductase (1991) (0)
- Localization ofribonucleotide reductase inmammaliancells (1984) (0)
- VIII. THE EFFECTS OF ATP AND dATP IN THE CDP REDUCTASE SYSTEM FROM E. COLI* BY ARNE HOLMGREN, PETER REICHARD, AND LARS THELANDER (0)
- En litteraturstudie om brännskadade individers upplevelse av lidande (2002) (0)
- Magnetic studies of reduced iron clusters in the mouse R2 subunit of ribonucleotide reductase (1995) (0)
- Studies of active and Co-substituted R2 subunit of ribonucleotide reductase from mouse (1997) (0)
- Calf thymus ribonucleotide reductase: purification and properties [proceedings]. (1977) (0)
- Characterization of the promoters of the mouse ribonucleotide reductase R1, R2 and p53R2-genes (2011) (0)
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