Laura Attardi
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Biology
Laura Attardi's Degrees
- PhD Molecular Biology University of California, San Francisco
- Bachelors Biology Stanford University
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Why Is Laura Attardi Influential?
(Suggest an Edit or Addition)According to Wikipedia, Laura Attardi is the Catharine and Howard Avery Professor of the school of medicine, and professor of radiation oncology and genetics at Stanford University where she leads the Attardi Laboratory. Attardi studies the tumor suppressor protein p53 and the gene that encodes it, TP53, to better understand mechanisms for preventing cancer.
Laura Attardi's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012) (2913)
- A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response (2010) (1942)
- Unravelling mechanisms of p53-mediated tumour suppression (2014) (1054)
- The role of apoptosis in cancer development and treatment response (2005) (936)
- Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. (2000) (633)
- In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs (1990) (620)
- A subset of p53-deficient embryos exhibit exencephaly (1995) (620)
- Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression (2011) (464)
- PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. (2000) (411)
- Assembly of recombinant TFIID reveals differential coactivator requirements for distinct transcriptional activators (1994) (380)
- Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects (2008) (372)
- Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses. (2013) (341)
- Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture (2014) (325)
- Perp Is a p63-Regulated Gene Essential for Epithelial Integrity (2005) (323)
- p53 at a glance (2010) (323)
- Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma (2015) (311)
- p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells. (2018) (304)
- Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene‐mediated apoptosis. (1996) (260)
- The role of p53 in tumour suppression: lessons from mouse models (1999) (224)
- Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer. (2005) (186)
- Deconstructing p53 transcriptional networks in tumor suppression. (2012) (178)
- An inducible long noncoding RNA amplifies DNA damage signaling (2016) (173)
- Desmosomes: new perpetrators in tumour suppression (2011) (168)
- Neat1 is a p53-inducible lincRNA essential for transformation suppression (2017) (159)
- Deciphering p53 signaling in tumor suppression. (2018) (157)
- Developmental Context Determines Latency of MYC-Induced Tumorigenesis (2004) (143)
- The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality (2005) (137)
- Increased Sensitivity to UV Radiation in Mice with a p53 Point Mutation at Ser389 (2004) (134)
- Functional analysis of NTF-1, a developmentally regulated Drosophila transcription factor that binds neuronal cis elements. (1989) (128)
- Activation of the p53-dependent G1 checkpoint response in mouse embryo fibroblasts depends on the specific DNA damage inducer (2004) (122)
- Perp Is a Mediator of p53-Dependent Apoptosis in Diverse Cell Types (2003) (118)
- The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation. (2008) (118)
- A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer. (2017) (117)
- Inappropriate p53 Activation During Development Induces Features of CHARGE Syndrome (2014) (115)
- The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor (2011) (112)
- Drosophila tissue-specific transcription factor NTF-1 contains a novel isoleucine-rich activation motif. (1993) (101)
- Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders (2018) (100)
- The Transactivation Domains of the p53 Protein. (2017) (88)
- Genome-Wide Analysis of p53 under Hypoxic Conditions (2006) (86)
- Probing p53 biological functions through the use of genetically engineered mouse models. (2005) (84)
- Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages (2011) (84)
- Deconstructing networks of p53-mediated tumor suppression in vivo. (2018) (81)
- In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models. (2010) (81)
- p53 and Tumor Suppression: It Takes a Network. (2021) (79)
- Loss of the p53/p63 Regulated Desmosomal Protein Perp Promotes Tumorigenesis (2010) (79)
- Deconstructing networks of p53-mediated tumor suppression in vivo (2017) (77)
- Human genome-edited hematopoietic stem cells phenotypically correct Mucopolysaccharidosis type I (2018) (76)
- The role of p53-mediated apoptosis as a crucial anti-tumor response to genomic instability: lessons from mouse models. (2005) (74)
- Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage (2015) (71)
- p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR) (2021) (68)
- Distinct p 53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression (2011) (57)
- Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis. (1997) (55)
- Specifications of the ACMG/AMP variant interpretation guidelines for germline TP53 variants (2020) (55)
- Not all p53 gain-of-function mutants are created equal (2013) (54)
- Multiple response elements and differential p53 binding control Perp expression during apoptosis. (2003) (54)
- Perp-etrating p53-Dependent Apoptosis (2004) (52)
- p63, Cell Adhesion and Survival (2007) (52)
- Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function. (2015) (51)
- Illuminating p53 function in cancer with genetically engineered mouse models. (2014) (50)
- Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage. (2007) (50)
- A New Perp in the Lineup: Linking p63 and Desmosomal Adhesion (2005) (49)
- Essential role for centromeric factors following p53 loss and oncogenic transformation. (2017) (45)
- The p53 family members have distinct roles during mammalian embryonic development (2017) (45)
- The role of p53 in developmental syndromes (2019) (40)
- Siva is an apoptosis-selective p53 target gene important for neuronal cell death (2007) (40)
- The Spatiotemporal Pattern and Intensity of p53 Activation Dictates Phenotypic Diversity in p53-Driven Developmental Syndromes. (2019) (39)
- Ectopic expression of wild-type or a dominant-negative mutant of transcription factor NTF-1 disrupts normal Drosophila development. (1993) (39)
- Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence (2008) (38)
- Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 (2016) (33)
- Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program. (2020) (32)
- Adult mice lacking the p53/p63 target gene Perp are not predisposed to spontaneous tumorigenesis but display features of ectodermal dysplasia syndromes (2006) (31)
- PERP regulates enamel formation via effects on cell–cell adhesion and gene expression (2011) (31)
- International Research Symposium on Ankyloblepharon‐Ectodermal Defects‐Cleft Lip/Palate (AEC) Syndrome (2009) (31)
- Cell of Origin Influences Pancreatic Cancer Subtype. (2021) (31)
- A healthy tan? (2007) (30)
- Loss of the Desmosomal Component Perp Impairs Wound Healing In Vivo (2010) (29)
- Differential PERP regulation by TP63 mutants provides insight into AEC pathogenesis (2009) (28)
- p53 suppresses muscle differentiation at the myogenin step in response to genotoxic stress (2014) (28)
- Mice lacking the p53/p63 target gene Perp are resistant to papilloma development. (2005) (28)
- Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer (2012) (27)
- The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development. (2015) (27)
- Loss of the desmosomal protein perp enhances the phenotypic effects of pemphigus vulgaris autoantibodies. (2009) (27)
- The requirement for perp in postnatal viability and epithelial integrity reflects an intrinsic role in stratified epithelia. (2006) (26)
- Dissecting p53 tumor suppressor function in vivo through the analysis of genetically modified mice (2006) (25)
- TRP53 activates a global autophagy program to promote tumor suppression (2013) (22)
- Tumor Suppression: p53 Alters Immune Surveillance to Restrain Liver Cancer (2013) (22)
- The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling (2021) (22)
- Conquering the complexity of p53 (2004) (21)
- Guilty as CHARGED: p53's expanding role in disease (2014) (21)
- ErbB2-dependent downregulation of a pro-apoptotic protein Perp is required for oncogenic transformation of breast epithelial cells (2016) (21)
- SKP-ing TAp63: stem cell depletion, senescence, and premature aging. (2009) (17)
- p73 and FoxJ1: Programming Multiciliated Epithelia. (2016) (17)
- p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen (2020) (16)
- Loss of the p53/p63 target PERP is an early event in oral carcinogenesis and correlates with higher rate of local relapse. (2013) (16)
- A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies. (2021) (16)
- Mutations in PERP Cause Dominant and Recessive Keratoderma. (2019) (15)
- RB goes mitochondrial. (2013) (15)
- Unimpaired Skin Carcinogenesis in Desmoglein 3 Knockout Mice (2012) (14)
- Cancer: A piece of the p53 puzzle (2015) (14)
- p53QS: An Old Mutant Teaches Us New Tricks (2005) (13)
- p19Arf is required for the cellular response to chronic DNA damage (2015) (13)
- Engaging the p53 metabolic brake drives senescence (2013) (12)
- Genome-Wide Analysis of p 53 under Hypoxic Conditions † (2006) (11)
- The Mettl3 epitranscriptomic writer amplifies p53 stress responses (2021) (9)
- SIDT2 RNA Transporter Promotes Lung and Gastrointestinal Tumor Development (2019) (8)
- Neat-en-ing up our understanding of p53 pathways in tumor suppression (2018) (7)
- A Balancing Act: p53 Activity from Tumor Suppression to Pathology and Therapeutic Implications. (2021) (7)
- A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies (2020) (7)
- Single Cell Transcriptomics Reveal Abnormalities in Neurosensory Patterning of the Chd7 Mutant Mouse Ear (2018) (6)
- The Department of Cell and Developmental Biology (2016) (6)
- An anterograde pathway for sensory axon degeneration gated by a cytoplasmic action of the transcriptional regulator P53. (2021) (4)
- Roles of p53 and pRB Tumor Suppressor Networks in Human Cancer: Insight from Studies in the Engineered Mouse (2012) (3)
- Siva plays a critical role in mouse embryonic development (2019) (3)
- PMP-22 / gas 3 family PERP , an apoptosis-associated target of p 53 , is a novel member of the (2000) (3)
- P53 orchestrates a complex symphony of cellular processes during oncosuppression (2021) (3)
- Pilot study of loss of the p53/p63 target gene PERP at the surgical margin as a potential predictor of local relapse in head and neck squamous cell carcinoma (2020) (2)
- Lessons on p53 from Mouse Models (2010) (2)
- Reply to Explaining the biological activity of transactivation-deficient p53 variants (2006) (1)
- Regulation of the DNA Damage Response by an Inducible Long Noncoding RNA (2013) (1)
- Puma- and Caspase9-mediated apoptosis is dispensable for p53-driven neural crest-based developmental defects (2021) (1)
- Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer (2012) (1)
- Zmat3 splices together p53-dependent tumor suppression (2021) (1)
- Abstract I15: Deciphering the origins of PDAC development (2019) (0)
- Abstract A28: Understanding the role of the tumor suppressor p53 in pancreatic cancer development (2018) (0)
- Abstract A15: Elucidating the role of p53 in the cellular origins of pancreatic cancer development (2019) (0)
- Siva plays a critical role in mouse embryonic development (2019) (0)
- Abstract A060: Characterizing acinar cell and ductal cell derived PDACs in mouse models (2022) (0)
- Abstract 3905: Epigenetic primming reveals the central role of epigenetic state in the anti-tumor activity of vitamin D in pancreatic ductal adenocarcinoma (2023) (0)
- Award Number: W81XWH-12-1-0175 TITLE: IDENTIFYING p53 TRANSACTIVATION DOMAIN 1-SPECIFIC INHIBITORS TO ALLEVIATE THE SIDE EFFECTS OF PROSTATE CANCER (2013) (0)
- The p53 Transactivation Domain 1-Dependent Response to Acute DNA Damage in Endothelial Cells Protects against Radiation-Induced Cardiac Injury (2021) (0)
- The spatiotemporal pattern and intensity of p53 activation during embryogenesis dictates phenotypic diversity in p53-driven developmental syndromes (2019) (0)
- Abstract 62: Loss of PERP p53/p63 target gene may indicate tumorigenesis at the margin and local recurrence (2017) (0)
- Award Number: W81XWH-12-1-0175 TITLE: IDENTIFYING p53 TRANSACTIVATION DOMAIN 1-SPECIFIC INHIBITORS TO ALLEVIATE THE SIDE EFFECTS OF PROSTATE CANCER (2013) (0)
- Abstract IA14: Deconstructing the origins of PDAC development (2020) (0)
- Identifying p53 Transactivation Domain 1-Specific Inhibitors to Alleviate the Side Effects of Prostate Cancer Therapy (2014) (0)
- Loss of the p53/p63 Target PERP is an Early Event in Oral Cavity Carcinogenesis and Correlates with Higher Local Failure Rate in These Tumors (2011) (0)
- Multifaceted role for p53 in pancreatic cancer suppression. (2023) (0)
- Dissecting p53 tumor suppressor function using transactivation mutant knock-in mice (2006) (0)
- Faculty Opinions recommendation of Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma. (2015) (0)
- Faculty Opinions recommendation of Suppression of lung adenocarcinoma progression by Nkx2-1. (2011) (0)
- Caspase 9: context-dependent killer (1998) (0)
- Abstract A45: Neat1 is a p53-inducible lincRNA important for pancreatic cancer suppression (2016) (0)
- Faculty Opinions recommendation of TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. (2011) (0)
- Abstract PR07: Deconstructing p53 transcriptional networks in pancreatic cancer suppression (2016) (0)
- Abstract 3403: Leveraging a p53 “super-tumor suppressor” to understand mechanisms of lung adenocarcinoma regression (2023) (0)
- Lessons on p 53 from Mouse Models (0)
- The XPC-ATM-JNK-γH2AX pathway mediates UV-induced apoptosis in response to DNA replication arrest. (2008) (0)
- Abstract PO-084: The role of p53 in the development of pancreatic ductal adenocarcinoma (2021) (0)
- HDAC, a key to pRb tumour suppression? (1998) (0)
- p53 and RB Cooperate to Suppress Transposable Elements (2023) (0)
- Faculty Opinions recommendation of The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma. (2012) (0)
- Abstract IA4: Deconstructing p53 pathways in vivo (2013) (0)
- Full Transcriptional Activation of p53 Target Genes is Not Necessary for Suppression of K-ras Induced Lung Adenocarcinomas (2008) (0)
- Analysis of African green monkey reducer specificity. (1986) (0)
- Referee Acknowledgement for 2016 (2017) (0)
- Abstract B12: Deciphering mechanisms of p53-mediated pancreatic cancer suppression. (2012) (0)
- Abstract IA07: Deconstructing p53 pathways in tumor suppression (2018) (0)
- p53 promotes revival stem cells in the regenerating intestine after severe radiation injury (2023) (0)
- Abstract A051: Understanding the Arf-p53 axis in PDAC suppression (2022) (0)
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