Laura Piddock
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Why Is Laura Piddock Influential?
(Suggest an Edit or Addition)According to Wikipedia, Laura Piddock is a microbiologist, specialising in antibiotics and antibiotic resistance in bacteria. She is Professor Emeritus at the University of Birmingham, UK and also Scientific Director within the Global Antibiotic Research and Development Partnership.
Laura Piddock's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Molecular mechanisms of antibiotic resistance (2014) (2623)
- Understanding the mechanisms and drivers of antimicrobial resistance (2016) (1383)
- Multidrug-resistance efflux pumps ? not just for resistance (2006) (1362)
- The Comprehensive Antibiotic Resistance Database (2013) (1349)
- Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria (2006) (1073)
- Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis: a consensus document. International Ascites Club. (2000) (855)
- The importance of efflux pumps in bacterial antibiotic resistance. (2003) (726)
- Tackling antibiotic resistance (2011) (653)
- Fluoroquinolone resistance: mechanisms, impact on bacteria, and role in evolutionary success. (2014) (648)
- Bacterial efflux pump inhibitors from natural sources. (2007) (485)
- Multidrug efflux pumps: structure, function and regulation (2018) (444)
- The crisis of no new antibiotics--what is the way forward? (2012) (386)
- Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals (1996) (379)
- Antibiotic resistance genes, integrons and multiple antibiotic resistance in thirty-five serotypes of Salmonella enterica isolated from humans and animals in the UK. (2004) (361)
- Multidrug efflux pumps in Gram-negative bacteria and their role in antibiotic resistance. (2014) (256)
- Prevalence of Mutations within the Quinolone Resistance-Determining Region of gyrA, gyrB, parC, and parE and Association with Antibiotic Resistance in Quinolone-Resistant Salmonella enterica (2004) (234)
- Structure, function and inhibition of RND efflux pumps in Gram-negative bacteria: an update. (2009) (233)
- The AcrAB–TolC efflux system of Salmonella enterica serovar Typhimurium plays a role in pathogenesis (2006) (218)
- Fluoroquinolone resistance in Salmonella serovars isolated from humans and food animals. (2002) (215)
- Towards the sustainable discovery and development of new antibiotics (2021) (198)
- Does the use of antimicrobial agents in veterinary medicine and animal husbandry select antibiotic-resistant bacteria that infect man and compromise antimicrobial chemotherapy? (1996) (187)
- Mutations in gyrA gene of quinolone-resistant Salmonella serotypes isolated from humans and animals (1996) (183)
- Identification and molecular characterisation of CmeB, a Campylobacter jejuni multidrug efflux pump. (2002) (182)
- Expression of acrB, acrF, acrD, marA, and soxS in Salmonella enterica Serovar Typhimurium: Role in Multiple Antibiotic Resistance (2004) (178)
- Mechanisms of Fluoroquinolone Resistance: An Update 1994–1998 (2012) (176)
- Prolonged treatment of Salmonella enterica serovar Typhimurium with commercial disinfectants selects for multiple antibiotic resistance, increased efflux and reduced invasiveness. (2007) (167)
- A comparison of methods used for measuring the accumulation of quinolones by Enterobacteriaceae, Pseudomonas aeruginosa and Staphylococcus aureus. (1991) (167)
- Role of mutation in the gyrA and parC genes of nalidixic-acid-resistant salmonella serotypes isolated from animals in the United Kingdom. (1998) (158)
- Techniques used for the determination of antimicrobial resistance and sensitivity in bacteria. Antimicrobial Agents Research Group. (1990) (157)
- Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilm. (2012) (151)
- Evidence for an Efflux Pump Mediating Multiple Antibiotic Resistance in Salmonella enterica Serovar Typhimurium (2000) (149)
- Discovery and development of new antibacterial drugs: learning from experience? (2018) (148)
- Fluoroquinolone resistance in Campylobacter species from man and animals: detection of mutations in topoisomerase genes. (2003) (146)
- Ciprofloxacin resistant Campylobacter spp. in humans: an epidemiological and laboratory study. (1996) (145)
- AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity (2015) (142)
- A 96-well plate fluorescence assay for assessment of cellular permeability and active efflux in Salmonella enterica serovar Typhimurium and Escherichia coli. (2010) (140)
- Quinolone resistance and Campylobacter spp. (1995) (127)
- Quinolone resistance in Escherichia coli. (2001) (127)
- Ciprofloxacin-Resistant Salmonella enterica Serovar Typhimurium Strains Are Difficult To Select in the Absence of AcrB and TolC (2006) (127)
- Inhibition of multidrug efflux as a strategy to prevent biofilm formation. (2014) (123)
- Cloning, sequencing and analysis of the structural gene and regulatory region of the Pseudomonas aeruginosa chromosomal ampC beta-lactamase. (1990) (122)
- RamA Confers Multidrug Resistance in Salmonella enterica via Increased Expression of acrB, Which Is Inhibited by Chlorpromazine (2008) (121)
- Metabolic constraints on the evolution of antibiotic resistance (2017) (119)
- Medicinal plant extracts with efflux inhibitory activity against Gram-negative bacteria. (2011) (118)
- The Global Consequence of Disruption of the AcrAB-TolC Efflux Pump in Salmonella enterica Includes Reduced Expression of SPI-1 and Other Attributes Required To Infect the Host (2009) (117)
- Antimicrobial-resistant pathogens in animals and man: prescribing, practices and policies. (2010) (116)
- Parallel evolutionary pathways to antibiotic resistance selected by biocide exposure (2015) (113)
- Triclosan resistance in Salmonella enterica serovar Typhimurium. (2008) (113)
- Absence of Mutations in marRAB or soxRS inacrB-Overexpressing Fluoroquinolone-Resistant Clinical and Veterinary Isolates of Escherichia coli (2001) (113)
- Phenotypic and Proteomic Characterization of Multiply Antibiotic-Resistant Variants of Salmonella enterica Serovar Typhimurium Selected Following Exposure to Disinfectants (2007) (112)
- Incidence and Mechanism of Ciprofloxacin Resistance in Campylobacter spp. Isolated from Commercial Poultry Flocks in the United Kingdom before, during, and after Fluoroquinolone Treatment (2005) (112)
- The Efflux Pump Inhibitor Reserpine Selects Multidrug-Resistant Streptococcus pneumoniae Strains That Overexpress the ABC Transporters PatA and PatB (2008) (112)
- Fluoroquinolone resistance (1998) (110)
- New quinolones and gram-positive bacteria (1994) (110)
- How to Measure Export via Bacterial Multidrug Resistance Efflux Pumps (2016) (108)
- Ciprofloxacin resistance in clinical isolates of Salmonella typhimurium obtained from two patients (1993) (108)
- Mechanisms of resistance to quinolones and clinical perspectives. (1989) (107)
- Non-traditional Antibacterial Therapeutic Options and Challenges. (2019) (107)
- Prevalence and Subtypes of Ciprofloxacin-Resistant Campylobacter spp. in Commercial Poultry Flocks before, during, and after Treatment with Fluoroquinolones (2005) (102)
- RamA, a Member of the AraC/XylS Family, Influences Both Virulence and Efflux in Salmonella enterica Serovar Typhimurium (2010) (102)
- The Acinetobacter baumannii Two-Component System AdeRS Regulates Genes Required for Multidrug Efflux, Biofilm Formation, and Virulence in a Strain-Specific Manner (2016) (102)
- Induction of the SOS response in Escherichia coli by 4‐quinolone antimicrobial agents (1987) (102)
- Strategies to combat antimicrobial resistance: anti-plasmid and plasmid curing (2018) (102)
- Multiple Regulatory Pathways Associated with High-Level Ciprofloxacin and Multidrug Resistance in Salmonella enterica Serovar Enteritidis: Involvement of ramA and Other Global Regulators (2008) (102)
- Activities of New Fluoroquinolones against Fluoroquinolone-Resistant Pathogens of the Lower Respiratory Tract (1998) (100)
- Expression of the efflux pump genes cmeB, cmeF and the porin gene porA in multiple-antibiotic-resistant Campylobacter jejuni. (2004) (98)
- Adaptive mutations produce resistance to ciprofloxacin (1997) (98)
- Accumulation of rifampicin by Mycobacterium aurum, Mycobacterium smegmatis and Mycobacterium tuberculosis. (2000) (96)
- Detection of gyrA Mutations in Quinolone-Resistant Salmonella enterica by Denaturing High-Performance Liquid Chromatography (2002) (95)
- Nonmedical Uses of Antibiotics: Time to Restrict Their Use? (2015) (95)
- Effect of triclosan or a phenolic farm disinfectant on the selection of antibiotic-resistant Salmonella enterica. (2004) (94)
- Prevalence of multiple antibiotic resistance in 443 Campylobacter spp. isolated from humans and animals. (2003) (92)
- Natural and synthetic compounds such as trimethoprim behave as inhibitors of efflux in Gram-negative bacteria. (2010) (92)
- Antibacterial terpenes from the oleo‐resin of Commiphora molmol (Engl.) (2008) (91)
- Commonly used farm disinfectants can select for mutant Salmonella enterica serovar Typhimurium with decreased susceptibility to biocides and antibiotics without compromising virulence. (2007) (89)
- Quinolone resistance in salmonella: clinical experience (1990) (88)
- In-vitro activity of quinolones and macrolides against mycobacteria. (1994) (87)
- Expression of Efflux Pump Gene pmrA in Fluoroquinolone-Resistant and -Susceptible Clinical Isolates of Streptococcus pneumoniae (2002) (87)
- Complete Sequence and Molecular Epidemiology of IncK Epidemic Plasmid Encoding blaCTX-M-14 (2011) (86)
- Involvement of the Putative ATP-Dependent Efflux Proteins PatA and PatB in Fluoroquinolone Resistance of a Multidrug-Resistant Mutant of Streptococcus pneumoniae (2006) (85)
- The accumulation of five antibacterial agents in porin-deficient mutants of Escherichia coli. (1993) (85)
- Teixobactin, the first of a new class of antibiotics discovered by iChip technology? (2015) (83)
- Antibiotic resistance: a geopolitical issue. (2014) (83)
- Quinolone resistance in veterinary isolates of Salmonella. (1994) (82)
- Exposure of Escherichia coli and Salmonella enterica serovar Typhimurium to triclosan induces a species-specific response, including drug detoxification. (2009) (80)
- Interaction of divalent cations, quinolones and bacteria. (1994) (79)
- Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium (2017) (78)
- SadA, a Trimeric Autotransporter from Salmonella enterica Serovar Typhimurium, Can Promote Biofilm Formation and Provides Limited Protection against Infection (2011) (77)
- Quinolone accumulation by Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli. (1999) (77)
- A novel gyrB mutation in a fluoroquinolone-resistant clinical isolate of Salmonella typhimurium. (1995) (75)
- The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity (2017) (75)
- Characterization of Fluoroquinolone Resistance among Veterinary Isolates of Avian Escherichia coli (2000) (74)
- Expression of homologous RND efflux pump genes is dependent upon AcrB expression: implications for efflux and virulence inhibitor design (2014) (74)
- Overexpression of patA and patB, Which Encode ABC Transporters, Is Associated with Fluoroquinolone Resistance in Clinical Isolates of Streptococcus pneumoniae (2010) (74)
- Development of a standardized susceptibility test for campylobacter with quality-control ranges for ciprofloxacin, doxycycline, erythromycin, gentamicin, and meropenem. (2004) (74)
- Clinically Relevant Mutant DNA Gyrase Alters Supercoiling, Changes the Transcriptome, and Confers Multidrug Resistance (2013) (70)
- Regulation of the AcrAB-TolC efflux pump in Enterobacteriaceae. (2017) (70)
- A Method for generating marker-less gene deletions in multidrug-resistant Acinetobacter baumannii (2013) (69)
- Correlation of quinolone MIC and inhibition of DNA, RNA, and protein synthesis and induction of the SOS response in Escherichia coli (1990) (69)
- Multiple transmissible genes encoding fluoroquinolone and third-generation cephalosporin resistance co-located in non-typhoidal Salmonella isolated from food-producing animals in China. (2014) (67)
- Mechanisms of Resistance in Nontyphoidal Salmonella enterica Strains Exhibiting a Nonclassical Quinolone Resistance Phenotype (2009) (67)
- Bactericidal activities of five quinolones for Escherichia coli strains with mutations in genes encoding the SOS response or cell division (1992) (65)
- β-Lactamase-Mediated β-Lactam Resistance in Campylobacter Species: Prevalence of Cj0299 (blaOXA-61) and Evidence for a Novel β-Lactamase in C. jejuni (2009) (64)
- Accumulation and killing kinetics of fifteen quinolones for Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. (1993) (63)
- Two Efflux Systems Expressed Simultaneously in Multidrug-Resistant Pseudomonas aeruginosa (2000) (61)
- Fluoroquinolones induce the expression of patA and patB, which encode ABC efflux pumps in Streptococcus pneumoniae. (2010) (61)
- Persistence of Transferable Extended-Spectrum-β-Lactamase Resistance in the Absence of Antibiotic Pressure (2012) (60)
- Evidence for Multiple-Antibiotic Resistance in Campylobacter jejuni Not Mediated by CmeB or CmeF (2005) (59)
- Reflecting on the final report of the O'Neill Review on Antimicrobial Resistance. (2016) (58)
- Accumulation of 10 Fluoroquinolones by Wild-Type or Efflux Mutant Streptococcus pneumoniae (2002) (58)
- Cefoxitin resistance in Bacteroides species: evidence indicating two mechanisms causing decreased susceptibility. (1987) (58)
- Emergence of fluoroquinolone resistance in the native Campylobacter coli population of pigs exposed to enrofloxacin. (2004) (57)
- Resistance and Tolerance to Tropodithietic Acid, an Antimicrobial in Aquaculture, Is Hard To Select (2011) (57)
- Contribution of Mutation at Amino Acid 45 of AcrR to acrB Expression and Ciprofloxacin Resistance in Clinical and Veterinary Escherichia coli Isolates (2005) (57)
- Accumulation of rifampicin by Escherichia coli and Staphylococcus aureus. (1998) (56)
- Global Transcriptome Analysis of the Responses of a Fluoroquinolone-Resistant Streptococcus pneumoniae Mutant and Its Parent to Ciprofloxacin (2006) (55)
- A pleiotropic, posttherapy, enoxacin-resistant mutant of Pseudomonas aeruginosa (1992) (55)
- Proteomic analysis of triclosan resistance in Salmonella enterica serovar Typhimurium. (2008) (52)
- Clinically Relevant Plasmid-Host Interactions Indicate that Transcriptional and Not Genomic Modifications Ameliorate Fitness Costs of Klebsiella pneumoniae Carbapenemase-Carrying Plasmids (2018) (49)
- Exploiting the Role of TolC in Pathogenicity: Identification of a Bacteriophage for Eradication of Salmonella Serovars from Poultry (2010) (49)
- Epidemiology and mechanisms of resistance among respiratory tract pathogens. (1998) (48)
- Mechanism of quinolone uptake into bacterial cells. (1991) (47)
- Activity of antibiotics used in human medicine for Campylobacter jejuni isolated from farm animals and their environment in Lancashire, UK. (2000) (47)
- Prevalence and mechanism of resistance to 'third-generation' cephalosporins in clinically relevant isolates of Enterobacteriaceae from 43 hospitals in the UK, 1990-1991. (1997) (46)
- Investigation of the Pseudomonas aeruginosa ampR gene and its role at the chromosomal ampC beta-lactamase promoter. (1993) (46)
- Ciprofloxacin selects for multidrug resistance in Salmonella enterica serovar Typhimurium mediated by at least two different pathways. (2009) (46)
- The accumulation of five quinolone antibacterial agents by Escherichia coli. (1990) (45)
- Understanding drug resistance will improve the treatment of bacterial infections (2017) (44)
- Wastewater for Urban Agriculture: A Significant Factor in Dissemination of Antibiotic Resistance. (2017) (44)
- RamA, which controls expression of the MDR efflux pump AcrAB-TolC, is regulated by the Lon protease (2013) (43)
- Periplasmic adaptor protein AcrA has a distinct role in the antibiotic resistance and virulence of Salmonella enterica serovar Typhimurium. (2009) (43)
- Effect of fluoroquinolone exposure on the proteome of Salmonella enterica serovar Typhimurium. (2006) (43)
- Efflux in Acinetobacter baumannii can be determined by measuring accumulation of H33342 (bis-benzamide) (2013) (43)
- In vitro activity of Ro 15-8074 and Ro 19-5247, two orally administered cephalosporin metabolites (1986) (41)
- Effect of hydrophobicity and molecular mass on the accumulation of fluoroquinolones by Staphylococcus aureus. (2001) (41)
- An investigation of the hydrophobicity of the quinolones. (1986) (40)
- Role of Topoisomerase Mutations and Efflux in Fluoroquinolone Resistance of Bacteroides fragilis Clinical Isolates and Laboratory Mutants (2004) (40)
- Raw wastewater irrigation for urban agriculture in three African cities increases the abundance of transferable antibiotic resistance genes in soil, including those encoding extended spectrum β-lactamases (ESBLs). (2019) (40)
- Selection of quinolone resistance in Streptococcus pneumoniae exposed in vitro to subinhibitory drug concentrations. (2007) (40)
- Genetic inactivation of acrAB or inhibition of efflux induces expression of ramA (2013) (39)
- Wastewater used for urban agriculture in West Africa as a reservoir for antibacterial resistance dissemination (2019) (38)
- Persistence of Campylobacter species, strain types, antibiotic resistance and mechanisms of tetracycline resistance in poultry flocks treated with chlortetracycline. (2008) (37)
- UK and European Union public and charitable funding from 2008 to 2013 for bacteriology and antibiotic research in the UK: an observational study. (2014) (37)
- Properties of the penicillin-binding proteins of four species of the genus Bacteroides (1986) (37)
- Modification of Enrofloxacin Treatment Regimens for Poultry Experimentally Infected with Salmonella enterica Serovar Typhimurium DT104 To Minimize Selection of Resistance (2006) (37)
- Understanding the basis of antibiotic resistance: a platform for drug discovery. (2014) (37)
- Medium Plays a Role in Determining Expression of acrB, marA, and soxS in Escherichia coli (2006) (36)
- Choice of Bacterial Growth Medium Alters the Transcriptome and Phenotype of Salmonella enterica Serovar Typhimurium (2013) (36)
- Mechanisms of Resistance to Fluoroquinolones (1998) (36)
- Inactivation or inhibition of AcrAB-TolC increases resistance of carbapenemase-producing Enterobacteriaceae to carbapenems. (2016) (36)
- The effect of mutations in the SOS response on the kinetics of quinolone killing. (1989) (35)
- Detection and characterization of pCT-like plasmid vectors for blaCTX-M-14 in Escherichia coli isolates from humans, turkeys and cattle in England and Wales. (2012) (35)
- Mutant prevention concentrations of ciprofloxacin and enrofloxacin for Salmonella enterica. (2004) (34)
- Phenotypic characterization of quinolone-resistant mutants of Enterobacteriaceae selected from wild type, gyrA type and multiply-resistant (marA) type strains. (1991) (33)
- Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump (2020) (33)
- Mechanism of action of sparfloxacin against and mechanism of resistance in gram-negative and gram-positive bacteria (1991) (33)
- Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis (2000) (33)
- Revitalizing the drug pipeline: AntibioticDB, an open access database to aid antibacterial research and development (2018) (32)
- Mechanism of action of lomefloxacin (1990) (31)
- Clinically relevant fluoroquinolone resistance due to constitutive overexpression of the PatAB ABC transporter in Streptococcus pneumoniae is conferred by disruption of a transcriptional attenuator (2014) (31)
- Accumulation of garenoxacin by Bacteroides fragilis compared with that of five fluoroquinolones. (2003) (31)
- Functional genomics to identify the factors contributing to successful persistence and global spread of an antibiotic resistance plasmid (2014) (31)
- Beyond Antimicrobial Resistance: Evidence for a Distinct Role of the AcrD Efflux Pump in Salmonella Biology (2016) (30)
- Assess drug-resistance phenotypes, not just genotypes (2016) (29)
- Antibacterial efflux systems : Frontiers in antimicrobial resistance (1997) (28)
- The effect of altered porin expression in Escherichia coli upon susceptibility to 4-quinolones. (1986) (28)
- Accumulation of five fluoroquinolones by Mycobacterium tuberculosis H37Rv. (2001) (28)
- Systematic review and meta-analysis of in vitro efficacy of antibiotic combination therapy against carbapenem-resistant Gram-negative bacilli. (2021) (28)
- Quinolone-resistant gyrase mutants demonstrate decreased susceptibility to triclosan (2017) (26)
- Reduced Fluoroquinolone Susceptibility in Salmonella enterica Isolates from Travelers, Finland (2009) (26)
- Antibiotic Resistance in Escherichia coli (2005) (26)
- Dissemination of pCT-Like IncK Plasmids Harboring CTX-M-14 Extended-Spectrum β-Lactamase among Clinical Escherichia coli Isolates in the United Kingdom (2012) (26)
- Regulation of RamA by RamR in Salmonella enterica Serovar Typhimurium: Isolation of a RamR Superrepressor (2012) (26)
- Only for substrate antibiotics are a functional AcrAB-TolC efflux pump and RamA required to select multidrug-resistant Salmonella Typhimurium. (2009) (25)
- Perturbed structural dynamics underlie inhibition and altered efflux of the multidrug resistance pump AcrB (2020) (25)
- Novel Ciprofloxacin-Resistant, Nalidixic Acid-Susceptible Mutant of Staphylococcus aureus (2002) (24)
- Selection of moxifloxacin-resistant Staphylococcus aureus compared with five other fluoroquinolones. (2003) (24)
- A comparison of the mechanisms of decreased susceptibility of aztreonam-resistant and ceftazidime-resistant Enterobacteriaceae. (1990) (24)
- To the G20: incentivising antibacterial research and development. (2017) (24)
- Role of gyrA mutation and loss of OprF in the multiple antibiotic resistance phenotype of Pseudomonas aeruginosa G49. (1996) (24)
- Acquisition and Loss of CTX-M-Producing and Non-Producing Escherichia coli in the Fecal Microbiome of Travelers to South Asia (2018) (23)
- Antibacterial efflux systems. (1997) (22)
- Fluoroquinolone treatment of experimental Salmonella enterica serovar Typhimurium DT104 infections in chickens selects for both gyrA mutations and changes in efflux pump gene expression. (2005) (22)
- High-level quinolone resistance amongst clinical isolates of Escherichia coli and Klebsiella pneumoniae from Spain. (1993) (22)
- Quinolone resistance and Campylobacter. (1999) (22)
- Effect of Carbon Dioxide on Testing of Susceptibilities of Respiratory Tract Pathogens to Macrolide and Azalide Antimicrobial Agents (1999) (21)
- Activity of 13 beta-lactam agents combined with BRL 42715 against beta-lactamase producing gram-negative bacteria compared to combinations with clavulanic acid, tazobactam and sulbactam. (1993) (21)
- Do phenothiazines possess antimicrobial and efflux inhibitory properties? (2019) (20)
- Newer mechanisms of resistance to β-lactam antibiotics in Gram-negative bacteria (1985) (20)
- gyrA of ofloxacin-resistant clinical isolates of Mycobacterium tuberculosis from Hong Kong. (1996) (20)
- Fitness and dissemination of disinfectant-selected multiple-antibiotic-resistant (MAR) strains of Salmonella enterica serovar Typhimurium in chickens. (2007) (19)
- Mechanisms of Resistance to Fluoroquinolones: State-of-the-Art 1992–1994 (2012) (19)
- β-Lactamase expression and outer membrane protein changes in cefpirome-resistant and ceftazidime-resistant Gram-negative bacteria (1991) (19)
- A Novel Gene Amplification Causes Upregulation of the PatAB ABC Transporter and Fluoroquinolone Resistance in Streptococcus pneumoniae (2015) (19)
- Complete Sequence and Molecular Epidemiology of IncK Epidemic Plasmid Encoding bla CTX-M-14 (2011) (18)
- The control of class I β-lactamase expression io Enterobacteriaceae and Pseudomonas aeruginosa (1991) (18)
- Accumulation of Norfloxacin by Mycobacterium aurum and Mycobacterium smegmatis (1998) (18)
- The antimicrobial activity of cefpirome, a new cephalosporin. (1985) (18)
- Amoxicillin therapy of poultry flocks: effect upon the selection of amoxicillin-resistant commensal Campylobacter spp. (2009) (17)
- Overexpression of marA, soxS and acrB in veterinary isolates of Salmonella enterica rarely correlates with cyclohexane tolerance. (2006) (17)
- Overexpression of RamA, Which Regulates Production of the Multidrug Resistance Efflux Pump AcrAB-TolC, Increases Mutation Rate and Influences Drug Resistance Phenotype (2020) (17)
- In vitro activity of CGP 31608, a new penem (1987) (16)
- Fluoroquinolone resistance in Haemophilus influenzae. (2003) (16)
- Bacterial flagellin promotes viral entry via an NF-kB and Toll Like Receptor 5 dependent pathway (2019) (16)
- New Multidrug Efflux Inhibitors for Gram-Negative Bacteria (2020) (15)
- Non-gyrA-mediated ciprofloxacin resistance in laboratory mutants of Streptococcus pneumoniae. (1997) (15)
- The immune response and antibacterial therapy (2015) (15)
- Addressing antimicrobial resistance in the UK and Europe. (2017) (15)
- In vitro antimicrobial combination testing of and evolution of resistance to the first-in-class spiropyrimidinetrione zoliflodacin combined with six therapeutically relevant antimicrobials for Neisseria gonorrhoeae. (2019) (15)
- Plasmid-mediated complementation of gyrA and gyrB in fluoroquinolone-resistant Bacteroides fragilis. (2003) (14)
- The O-Antigen Epitope Governs Susceptibility to Colistin in Salmonella enterica (2020) (14)
- High level fluoroquinolone resistance in Escherichia coli isolatedfrom animals in Turkey is due to multiple mechanisms (2016) (14)
- The TCA cycle is not required for selection or survival of multidrug-resistant Salmonella. (2012) (14)
- HIV Drugs Inhibit Transfer of Plasmids Carrying Extended-Spectrum β-Lactamase and Carbapenemase Genes (2020) (14)
- The Global Antibiotic Research and Development Partnership (GARDP) Not-for-Profit Model of Antibiotic Development. (2020) (14)
- Antibiotic resistance genes are abundant and diverse in raw sewage used for urban agriculture in Africa and associated with urban population density. (2019) (14)
- Selection and characterization of cefepime-resistant gram-negative bacteria. (1991) (14)
- Ciprofloxacin and ceftriaxone alter cytokine responses, but not Toll-like receptors, to Salmonella infection in vitro. (2016) (13)
- Should quinolones be used in the treatment of bacterial infections in neutropenic patients? (1993) (13)
- Ask the experts: how to curb antibiotic resistance and plug the antibiotics gap? (2016) (13)
- Antimicrobial activity and accumulation of moxifloxacin in quinolone-susceptible bacteria. (1999) (12)
- Antibacterials - mechanisms of action. (1998) (12)
- The effect of imipenem on strains of Enterobacteriaceae expressing Richmond & Sykes class I beta-lactamases. (1987) (12)
- The global antibiotic research and development partnership (GARDP): researching and developing new antibiotics to meet global public health needs (2019) (12)
- Selection of quinolone-resistant mutants of Haemophilus influenzae and Streptococcus pneumoniae. (1992) (11)
- CsrA maximizes expression of the AcrAB multidrug resistance transporter (2017) (11)
- Agar Dilution and Disk Diffusion Susceptibility Testing of Campylobacter spp. (2007) (11)
- The selection and frequency of streptococci with decreased susceptibility to ofloxacin compared with other quinolones. (1988) (11)
- Accumulation of Norfloxacin byBacteroides fragilis (2000) (11)
- The role of combination therapy in the treatment of severe infections caused by carbapenem resistant gram-negatives: a systematic review of clinical studies (2021) (11)
- The 2019 Garrod Lecture: MDR efflux in Gram-negative bacteria-how understanding resistance led to a new tool for drug discovery. (2019) (11)
- Metabolomics Reveal Potential Natural Substrates of AcrB in Escherichia coli and Salmonella enterica Serovar Typhimurium (2021) (10)
- Antibiotic action: helping deliver action plans and strategies. (2013) (10)
- Potential Antibiotics for the Treatment of Neonatal Sepsis Caused by Multidrug-Resistant Bacteria (2021) (10)
- Resistance to Quinolones and Fluoroquinolones (1989) (10)
- The Global Antibiotic Research and Development Partnership (GARDP): a not-for-profit antibiotic development organisation. (2018) (10)
- Opening Pandora’s box: high level resistance to antibiotics of last resort in Gram negative bacteria from Nigeria (2018) (9)
- The need for new antibiotics (2010) (8)
- The killing action of fleroxacin upon Bacteroides fragilis. (1989) (8)
- Activity of faropenem and imipenem for ciprofloxacin-resistant bacteria. (2003) (8)
- Amikacin Combined with Fosfomycin for Treatment of Neonatal Sepsis in the Setting of Highly Prevalent Antimicrobial Resistance (2021) (8)
- Accumulation of KRM-1648 by Mycobacterium aurum and Mycobacterium tuberculosis. (2000) (8)
- The in-vitro activity of Ro 17-2301, a new monobactam, compared with other antimicrobial agents. (1985) (8)
- Ciprofloxacin resistance in Salmonella serotypes. (1990) (7)
- Activity of meropenem against imipenem-resistant bacteria and selection in vitro of carbapenem-resistantEnterobacteriaceae (1992) (7)
- Molecular Mechanisms of Antibiotic Resistance – Part I (2019) (7)
- The antibacterial action of the 4-quinolones (1985) (7)
- Erratum for Richmond et al., The Acinetobacter baumannii Two-Component System AdeRS Regulates Genes Required for Multidrug Efflux, Biofilm Formation, and Virulence in a Strain-Specific Manner (2016) (7)
- Alternative explanation for indole-induced antibiotic tolerance in Salmonella (2013) (7)
- Author Correction: Multidrug efflux pumps: structure, function and regulation (2018) (6)
- High In Vitro Susceptibility to the First-in-Class Spiropyrimidinetrione Zoliflodacin among Consecutive Clinical Neisseria gonorrhoeae Isolates from Thailand and South Africa (2019) (6)
- Activity of FCE 22101 against methicillin-resistant Staphylococcus aureus and affinity for penicillin binding proteins. (1989) (6)
- Clinical management of severe infections caused by carbapenem-resistant Gram-negative bacteria: a worldwide cross-sectional survey addressing the use of antibiotic combinations. (2021) (6)
- A Nonprofit Drug Development Model Is Part of the Antimicrobial Resistance (AMR) Solution (2021) (6)
- Governing Global Antimicrobial Resistance: 6 Key Lessons From the Paris Climate Agreement. (2022) (6)
- High-throughput sequencing data and antibiotic resistance mechanisms of soil microbial communities in non-irrigated and irrigated soils with raw sewage in African cities (2019) (6)
- Activity of Bay y3118 against quinolone-susceptible and -resistant gram-negative and gram-positive bacteria (1994) (5)
- Molecular Characterisation of Plasmids Encoding blaCTX-M from Faecal Escherichia coli in Travellers Returning to the UK from South Asia. (2021) (5)
- Together towards a common goal: REVIVE, a community of antimicrobial researchers brought together by the Global Antibiotic Research & Development Partnership (GARDP). (2019) (5)
- Faculty Opinions recommendation of Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in Mammalian cells. (2013) (5)
- Time dependent asymptotic analysis of the gene regulatory network of the AcrAB-TolC efflux pump system in gram-negative bacteria (2021) (5)
- Antibiotics in media for isolation of Campylobacter spp. do not enhance resistance. (2004) (4)
- In vitro studies of S-25930 and S-25932, two new 4-quinolones (1986) (4)
- NewQuinolones andGram-Positive Bacteria (1994) (3)
- Erratum: Quinolone resistance in Escherichia coli (2001) (3)
- Cross-resistance of nalidixic acid resistantEnterobacteriaceae to new quinolones and other antimicrobials (1986) (3)
- Corrigendum to “A novel gyrB mutation in a fluoroquinolone-resistant clinical isolate of Salmonella typhimurium”[FEMS Microbiol. Lett. 132 (1995) 57′60] (1996) (3)
- Activity of cefpirome combined with beta-lactamase inhibitors and affinity for the penicillin-binding proteins of methicillin-resistantStaphylococcus aureus (1992) (3)
- Detection and characterization of pCT-like plasmid vectors for bla CTX-M-14 in Escherichia coli isolates from humans, turkeys and cattle in England and Wales (2012) (3)
- Induction of -lactamases in Gram-negative bacilli (1987) (3)
- Comparison of the mechanism of action and resistance of two new fluoroquinolones, rufloxacin and MF961 with those of ofloxacin and fleroxacin in gram-negative and gram-positive bacteria. (1993) (3)
- Accumulation of Norfloxacin by Bacteroides fragilis (2000) (3)
- European Antibiotic Awareness Day and access to antibiotics (2012) (3)
- beta-Lactamase expression and outer membrane protein changes in cefpirome-resistant and ceftazidime-resistant gram-negative bacteria. (1991) (3)
- High-level quinolone resistance in Pseudomonas aeruginosa. (1992) (2)
- Raw wastewater irrigation for urban agriculture in Africa increases the diversity of transferable antibiotic resistances genes in soil, including those encoding ESBLs (2019) (2)
- Effect of Cations and EDTA upon the Activity of 18 Quinolones, Gentamicin, Ceftazidime and Polymixin against Gram-Negative and Gram-Positive Bacteria (1993) (2)
- The control of class I beta-lactamase expression in Enterobacteriaceae and Pseudomonas aeruginosa. (1991) (2)
- Newer mechanisms of resistance to beta-lactam antibiotics in gram-negative bacteria. (1985) (2)
- Preincubation of Pneumococci with β-Lactams Alone or Combined with Levofloxacin Prevents Quinolone-Induced Resistance without Increasing Intracellular Levels of Levofloxacin (2005) (2)
- The mode of action of Sch 34343: affinity for the penicillin binding proteins of Escherichia coli K-12 and Bacteroides fragilis. (1985) (2)
- Disinfectant Resistance in Bacteria (2019) (2)
- In vivo studies on antibiotic combination for the treatment of carbapenem-resistant Gram-negative bacteria: a systematic review and meta-analysis protocol (2020) (2)
- EnvR is a potent repressor of acrAB transcription in Salmonella (2022) (1)
- Resistance to antimicorbial agents in Salmonella typhi in Vietnam: clinical response to therapy and molecular mechanisms (1998) (1)
- Identi¢cation and molecular characterisation of CmeB, a Campylobacter jejuni multidrug e¥ux pump (2002) (1)
- Activity of biapenem (LJC 10627) against 51 imipenem-resistant bacteria and selection and characterisation of biapenem-resistant mutants. (1995) (1)
- Evidence for Multiple-Antibiotic Resistance in Campylobacter jejuni Not Mediated by CmeB or CmeF (2006) (1)
- Less ns t be Learnt from pharma about discovery and deveLopment of new antibacteriaL drugs (2013) (1)
- Faculty of 1000 evaluation for Antibiotic resistance and its cost: is it possible to reverse resistance? (2011) (1)
- Properties ofthePenicillin-Bindi ng Proteins ofFourSpecies ofthe GenusBacteroides (1986) (1)
- Induction of beta-lactamases in gram-negative bacilli. (1987) (1)
- Post-therapy multiply resistant mutant of Pseudomonas aeruginosa. (2002) (1)
- Characterization of FCE 22101-resistant Enterobacteriaceae and the effect of FCE 22101 upon the activity of anti-pseudomonal beta-lactams for Pseudomonas aeruginosa. (1991) (1)
- BSAC Vanguard Report Series: The future of drug development. (2022) (1)
- An interview with Laura Piddock - by Felicity Poole, commissioning editor (2023) (1)
- Functional genomics to identify the factors contributing to successful persistence and global spread of an antibiotic resistance plasmid (2014) (1)
- Perturbed structural dynamics underlie inhibition and altered specificity of the multidrug efflux pump AcrB (2020) (1)
- Non-medical uses of antibacterial compounds ( antibiotics ) : time to restrict their use ? (2015) (0)
- P884 Effect of multiple passages of S. typhimurium in the presence of disinfectants on susceptibility to antimicrobials, on persistence in the one-day-old chick model and effiux systems (2007) (0)
- The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity (2017) (0)
- Faculty of 1000 evaluation for The 2010 Garrod Lecture: the dimensions of evolution in antibiotic resistance: ex unibus plurum et ex pluribus unum. (2011) (0)
- Mechanism ofAction ofLomefloxacin (1990) (0)
- University of Birmingham A novel gene amplification causes upregulation of the PatAB ABC transporter and fluoroquinolone resistance in Streptococcus pneumoniae (2015) (0)
- P1160 Development of a rapidfiuorescence assay in 96 well plate as-say for multiple antibiotic resistant Salmonella typhimurium (2007) (0)
- Activity of Bay y 3118 against Quinolone-Susceptible and-Resistant Gram-Negative and Gram-Positive Bacteria (0)
- Quinolone-resistant gyrase mutants demonstrate decreased susceptibility to 1 triclosan due to de-repression of general stress response pathways 2 3 (2017) (0)
- Assessment of flomoxef combined with amikacin in a hollow-fibre infection model for the treatment of neonatal sepsis in low- and middle-income healthcare settings (2022) (0)
- Faculty Opinions recommendation of The RcsCB His-Asp phosphorelay system is essential to overcome chlorpromazine-induced stress in Escherichia coli. (2013) (0)
- Escherichia coli Veterinary Isolates of Fluoroquinolone-Resistant Clinical and-Overexpressing acrB in soxRS or marRAB Absence of Mutations in (2001) (0)
- Bacterial flagellin promotes viral entry via an NF-kB and Toll Like Receptor 5 dependent pathway (2019) (0)
- O06.2 In vitro combination testing and selection of resistance to zoliflodacin combined with six antimicrobials for N. gonorrhoeae (2019) (0)
- Laura Piddock: Fights antibiotic resistance (2015) (0)
- of four species of the genus Bacteroides. Properties of the penicillin-binding proteins (2013) (0)
- RamA, a Member of the AraC/XylS Family, Influences Both Virulence and Efflux in Salmonella enterica Serovar Typhimurium (cid:1) † (2010) (0)
- Correlation ofQuinolone MICandInhibition ofDNA,RNA, andProtein Synthesis andInduction oftheSOS Response inEscherichia coli (1990) (0)
- EPI-Net One Health reporting guideline for antimicrobial consumption and resistance surveillance data: a Delphi approach (2022) (0)
- 30 Determining a potential alternative empirical antibiotic regimen for the treatment of neonatal sepsis in low- and middle-income settings using pre-clinical in vitro techniques (2022) (0)
- University of Birmingham Assess drug-resistance phenotypes , not just genotypes (2016) (0)
- University of Birmingham Non-traditional antibacterial therapeutic options and challenges (2019) (0)
- Towards the sustainable discovery and development of new antibiotics. (2021) (0)
- Clinical Efficacy of Combination Therapy for the Treatment of Severe Infections Caused by Carbapenem Resistant Gram-Negatives. A Systematic Review of Clinical Studies (2021) (0)
- Comparison of the ability of six fluoroquinolones to select resistant Staphylococcus aureus (2003) (0)
- Flomoxef and fosfomycin in combination for the treatment of neonatal sepsis in the setting of highly prevalent antimicrobial resistance (2022) (0)
- Contribution of efflux to antibiotic resistance in Campylobacter isolated from poultry in Senegal. (2009) (0)
- Corrections (1969) (0)
- The immune response and antibacterial therapy (2014) (0)
- The Efflux Pump Inhibitor Reserpine Selects Multidrug-Resistant Streptococcus pneumoniae Strains That Overexpress the ABC Transporters PatA and PatB (cid:1) † (2008) (0)
- Different impacts of naturally occurring variants of the globally disseminated carbapenemase-encoding plasmid pKpQIL on the biology of host strains (2018) (0)
- Modification of Enrofloxacin Treatment Regimens for Poultry Experimentally Infected with Salmonella enterica Serovar Typhimurium DT104 To Minimize Selection of Resistance (cid:1) (2006) (0)
- To Select in the Absence of AcrB and TolC Serovar Typhimurium Strains Are Difficult Salmonella enterica Ciprofloxacin-Resistant (2005) (0)
- Preincubation of Pneumococci with (cid:2) -Lactams Alone or Combined with Levofloxacin Prevents Quinolone-Induced Resistance without Increasing Intracellular Levels of Levofloxacin (2005) (0)
- High-Throughput Determination of Bacterial Growth Kinetics using a FLUOstar OPTIMA (2006) (0)
- University of Birmingham Strategies to combat antimicrobial resistance: antiplasmid and plasmid curing (2018) (0)
- Pandemic influenza and antibiotics (2018) (0)
- Time dependent asymptotic analysis of the gene regulatory network of the AcrAB-TolC efflux pump system in gram-negative bacteria (2021) (0)
- Co-ordinated regulation of multidrug efflux and biofilm formation in 1 Salmonella . 2 (2016) (0)
- Author Correction: Multidrug efflux pumps: structure, function and regulation (2018) (0)
- Faculty Opinions recommendation of Some ligands enhance the efflux of other ligands by the Escherichia coli multidrug pump AcrB. (2013) (0)
- Multidrug efflux pumps: structure, function and regulation (2018) (0)
- Acquisition and Loss of CTX-M-Producing and Non-Producing <named-content content-type='genus-species'>Escherichia coli</named-content> in the Fecal Microbiome of Travelers to South Asia (2018) (0)
- Faculty Opinions recommendation of Clonal expansion during Staphylococcus aureus infection dynamics reveals the effect of antibiotic intervention. (2014) (0)
- A Method for generating marker-less gene deletions in multidrug-resistant Acinetobacter baumannii (2013) (0)
- (cid:2) -Lactamase-Mediated (cid:2) -Lactam Resistance in Campylobacter Species: Prevalence of Cj0299 ( bla OXA-61 ) and Evidence for a Novel (cid:2) -Lactamase in C . jejuni (cid:1) (2009) (0)
- Two Efflux Systems Expressed Simultaneously in Multidrug-Resistant Pseudomonas aeruginosa (2001) (0)
- Absence, loss-of-function, or inhibition of Escherichia coli AcrB does not increase expression of other efflux pump genes supporting the discovery of AcrB inhibitors as antibiotic adjuvants (2021) (0)
- Mechanism ofAction ofSparfloxacin against andMechanism of Resistance inGram-Negative andGram-Positive Bacteria (1991) (0)
- Avoiding the doomsday predictions: The dual crises of antibiotic resistance and the failing antibiotic pipeline (2013) (0)
- InVitro Activity ofCGP31608, a New Penem (1987) (0)
- The PBPs of Bacteroides fragilis. (1983) (0)
- Ciprofloxacin Resistance inClinical Isolates ofSalmonella typhimurium Obtained fromTwoPatients (1993) (0)
- High Level Quinolone Resistance among Escherichia coli Clinical Isolates (2012) (0)
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