Laurence Pearl
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British biologist
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Why Is Laurence Pearl Influential?
(Suggest an Edit or Addition)According to Wikipedia, Laurence Harris Pearl FRS FMedSci is a British biochemist and structural biologist who is currently Professor of Structural Biology in the Genome Damage and Stability Centre and was Head of the School of Life Sciences at the University of Sussex.
Laurence Pearl's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone (1997) (1222)
- Structure and mechanism of the Hsp90 molecular chaperone machinery. (2006) (1059)
- Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. (1999) (956)
- Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex (2006) (882)
- GSK-3-selective inhibitors derived from Tyrian purple indirubins. (2003) (773)
- ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo (1998) (722)
- Crystal Structure of Glycogen Synthase Kinase 3β Structural Basis for Phosphate-Primed Substrate Specificity and Autoinhibition (2001) (626)
- A structural model for the retroviral proteases (1987) (531)
- DNA repair, genome stability and cancer: a historical perspective (2015) (515)
- Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. (2002) (507)
- The ATPase cycle of Hsp90 drives a molecular ‘clamp’ via transient dimerization of the N‐terminal domains (2000) (485)
- NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. (2008) (454)
- Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions. (2003) (433)
- Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)‐domain co‐chaperones (1999) (428)
- The Hsp90 molecular chaperone: an open and shut case for treatment. (2008) (421)
- Therapeutic opportunities within the DNA damage response (2015) (394)
- 4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer. (2007) (393)
- Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. (2005) (388)
- The structural basis of specific base-excision repair by uracil–DNA glycosylase (1996) (366)
- Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. (2004) (349)
- The Mechanism of Hsp90 Regulation by the Protein Kinase-Specific Cochaperone p50cdc37 (2004) (345)
- Structure and in vivo function of Hsp90. (2000) (321)
- Structural basis for recruitment of glycogen synthase kinase 3β to the axin—APC scaffold complex (2003) (298)
- Structure and function in the uracil-DNA glycosylase superfamily. (2000) (296)
- Structure of an Hsp90-Cdc37-Cdk4 complex. (2006) (292)
- Regulation of Hsp90 ATPase Activity by the Co-chaperone Cdc37p/p50 cdc37 * (2002) (269)
- Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair. (2006) (265)
- Structure and functional relationships of Hsp90. (2003) (247)
- Crystal Structure of a G:T/U Mismatch-Specific DNA Glycosylase Mismatch Recognition by Complementary-Strand Interactions (1998) (239)
- Hsp90 and Cdc37 -- a chaperone cancer conspiracy. (2005) (234)
- Recursive PCR: a novel technique for total gene synthesis. (1992) (233)
- Structural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the β‐clamp (2003) (227)
- Crystal structure of the beta-glycosidase from the hyperthermophilic archeon Sulfolobus solfataricus: resilience as a key factor in thermostability. (1997) (222)
- A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone (1997) (221)
- Characterization of HIV‐1 neutralization escape mutants (1989) (218)
- Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response (2011) (210)
- The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks (2012) (203)
- Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection (2016) (202)
- The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. (2005) (200)
- Structure, function, and mechanism of the Hsp90 molecular chaperone. (2001) (194)
- Co-chaperone Regulation of Conformational Switching in the Hsp90 ATPase Cycle* (2004) (192)
- Hsp90-Dependent Activation of Protein Kinases Is Regulated by Chaperone-Targeted Dephosphorylation of Cdc37 (2008) (184)
- Three-dimensional structure, specificity and catalytic mechanism of renin (1983) (184)
- High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity. (2004) (183)
- Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery (2004) (173)
- A Two-Hybrid Screen of the Yeast Proteome for Hsp90 Interactors Uncovers a Novel Hsp90 Chaperone Requirement in the Activity of a Stress-Activated Mitogen-Activated Protein Kinase, Slt2p (Mpk1p) (2005) (171)
- Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function. (2010) (168)
- Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites (2008) (165)
- Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. (2012) (164)
- Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity. (2011) (155)
- Structural basis for uracil recognition by archaeal family B DNA polymerases (2002) (155)
- Structural basis for recruitment of BRCA2 by PALB2 (2009) (151)
- Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor. (2006) (146)
- Regulation of DNA Replication through Sld3-Dpb11 Interaction Is Conserved from Yeast to Humans (2011) (143)
- Trans‐activation of the DNA‐damage signalling protein kinase Chk2 by T‐loop exchange (2006) (138)
- A read-ahead function in archaeal DNA polymerases detects promutagenic template-strand uracil. (1999) (137)
- ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system. (2013) (135)
- Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase (2007) (133)
- Structural and mechanistic insights into ras association domains of phospholipase C epsilon. (2006) (132)
- Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1. (2003) (132)
- Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1. (2003) (131)
- Review: The HSP90 molecular chaperone—an enigmatic ATPase (2016) (129)
- Structural model of full‐length human Ku70–Ku80 heterodimer and its recognition of DNA and DNA‐PKcs (2007) (128)
- Crystal structure of the rad9-rad1-hus1 DNA damage checkpoint complex--implications for clamp loading and regulation. (2009) (127)
- DNA structure and perturbation by drug binding. (1987) (126)
- Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues (2007) (121)
- Crystal structure of a thwarted mismatch glycosylase DNA repair complex (1999) (119)
- Structural Basis for Assembly of Hsp90-Sgt1-CHORD Protein Complexes: Implications for Chaperoning of NLR Innate Immunity Receptors (2010) (118)
- Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). (2005) (118)
- Crystal structure of an octameric RuvA-Holliday junction complex. (1998) (117)
- Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors. (2004) (117)
- Identification of the Axin and Frat Binding Region of Glycogen Synthase Kinase-3* (2002) (115)
- Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2. (2002) (114)
- Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes (2008) (114)
- High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes (1987) (108)
- X-ray analyses of aspartic proteinases. The three-dimensional structure at 2.1 A resolution of endothiapepsin. (1994) (104)
- A Mechanism for the Inhibition of DNA-PK-Mediated DNA Sensing by a Virus (2013) (104)
- The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins (2011) (103)
- In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. (2007) (103)
- Glycogen synthase kinase-3 inhibition by lithium and beryllium suggests the presence of two magnesium binding sites. (2002) (101)
- Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase. (2002) (100)
- CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. (2011) (92)
- The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis (2008) (92)
- Structural Basis for Phosphorylation-Dependent Recruitment of Tel2 to Hsp90 by Pih1 (2014) (92)
- Crystal structure and induction mechanism of AmiC–AmiR: a ligand‐regulated transcription antitermination complex (1999) (91)
- Visualization of a DNA-PK/PARP1 complex (2012) (90)
- Nucleotide mimicry in the crystal structure of the uracil-DNA glycosylase–uracil glycosylase inhibitor protein complex (1995) (90)
- Activation segment exchange: a common mechanism of kinase autophosphorylation? (2007) (88)
- Visualization of DNA‐induced conformational changes in the DNA repair kinase DNA‐PKcs (2003) (88)
- Macrophage migration inhibitory factor of the parasitic nematode Trichinella spiralis. (2001) (84)
- Enzyme thermostability and thermoactivity. (1996) (83)
- Crystal structure of the CCTgamma apical domain: implications for substrate binding to the eukaryotic cytosolic chaperonin. (2002) (79)
- Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture. (2007) (77)
- Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK (2009) (76)
- Regulation of protein kinases in insulin, growth factor and Wnt signalling. (2002) (75)
- Structure of an archaeal PCNA1–PCNA2–FEN1 complex: elucidating PCNA subunit and client enzyme specificity (2006) (75)
- Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair. (2008) (74)
- Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1 (2010) (73)
- Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor. (2002) (72)
- Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors. (2008) (69)
- MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis (2019) (68)
- The 3D solution structure of the C-terminal region of Ku86 (Ku86CTR). (2004) (68)
- Sequence specificity of retroviral proteases. (1987) (67)
- An Iron-Sulfur Cluster in the Family 4 Uracil-DNA Glycosylases* (2002) (66)
- Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2. (2009) (64)
- Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol. (2006) (63)
- Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast. (2003) (61)
- Crystal structure of the fission yeast mitochondrial Holliday junction resolvase Ydc2 (2001) (60)
- The catalytic mechanism of aspartic proteinases (1987) (60)
- Expressed in the Yeast Saccharomyces cerevisiae, Human ERK5 Is a Client of the Hsp90 Chaperone That Complements Loss of the Slt2p (Mpk1p) Cell Integrity Stress-Activated Protein Kinase (2006) (59)
- MoKCa database—mutations of kinases in cancer (2008) (58)
- Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease (2016) (56)
- Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism (2016) (55)
- ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with γH2AX (2015) (55)
- A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s (2009) (54)
- PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2 (2016) (54)
- Specialized interfaces of Smc5/6 control hinge stability and DNA association (2017) (53)
- A molecular model for proflavine-DNA intercalation. (1988) (53)
- The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins (2016) (52)
- Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex (2005) (52)
- Molecular modelling of the interactions of tetra-(4-N-methylpyridyl) porphin with TA and CG sites on DNA. (1987) (52)
- The baculovirus Autographa californica nuclear polyhedrosis virus genome includes a papain-like sequence. (1992) (51)
- Chaperone ligand-discrimination by the TPR-domain protein Tah1 (2008) (51)
- Crystal structure of glycyl endopeptidase from Carica papaya: a cysteine endopeptidase of unusual substrate specificity. (1995) (51)
- Structural basis of the radicicol resistance displayed by a fungal hsp90. (2009) (50)
- Transcription antitermination regulation of the Pseudomonas aeruginosa amidase operon. (1996) (50)
- Generation of molecular surfaces for graphic display (1983) (49)
- Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors. (2003) (49)
- Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2. (2010) (48)
- 3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3. (2013) (48)
- Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. (2011) (46)
- Molecular characterization of macbecin as an Hsp90 inhibitor. (2008) (46)
- Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins (2013) (45)
- Uracil-DNA glycosylase activities in hyperthermophilic micro-organisms. (1996) (45)
- Investigating the protein-protein interactions of the yeast Hsp90 chaperone system by two-hybrid analysis: potential uses and limitations of this approach (2004) (45)
- The Structure of the R2TP Complex Defines a Platform for Recruiting Diverse Client Proteins to the HSP90 Molecular Chaperone System (2017) (44)
- The problem with pyrimidines (1996) (44)
- RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex (2018) (44)
- A second front against AIDS (1989) (43)
- Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System (2017) (43)
- Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1 (2019) (43)
- Selective cleavage of glycyl bonds by papaya proteinase IV (1990) (43)
- Direct Measurement of the Substrate Preference of Uracil-DNA Glycosylase* (1998) (43)
- Antitermination of amidase expression in Pseudomonas aeruginosa is controlled by a novel cytoplasmic amide‐binding protein. (1993) (42)
- Crystal structure of AmiC: the controller of transcription antitermination in the amidase operon of Pseudomonas aeruginosa. (1994) (41)
- A novel expression system of domain I of human beta2 glycoprotein I in Escherichia coli (2006) (41)
- Combinatorial Domain Hunting: An effective approach for the identification of soluble protein domains adaptable to high‐throughput applications (2006) (38)
- Regulation of Hsp 90 ATPase Activity by the Co-chaperone Cdc 37 p / p 50 cdc 37 (2002) (36)
- Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4(TopBP1). (2013) (35)
- The crystal structure of the DNA-binding drug berenil: molecular modelling studies of berenil-DNA complexes. (1987) (35)
- Glycogen Synthase Kinase 3 beta. (2002) (34)
- The Hsp90 of Candida albicans can confer Hsp90 functions in Saccharomyces cerevisiae: a potential model for the processes that generate immunogenic fragments of this molecular chaperone in C. albicans infections. (1999) (34)
- Towards meeting the paracelsus challenge: The design, synthesis, and characterization of paracelsin‐43, an α‐helical protein with over 50% sequence identity to an all‐β protein (1996) (34)
- Detection of the ATPase Activity of the Molecular Chaperones Hsp90 and Hsp72 Using the Transcreener™ ADP Assay Kit (2010) (33)
- Identification of Two New Genes in the Pseudomonasaeruginosa Amidase Operon, Encoding an ATPase (AmiB) and a Putative Integral Membrane Protein (AmiS) (*) (1995) (33)
- The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase. (2011) (33)
- An Artemis polymorphic variant reduces Artemis activity and confers cellular radiosensitivity. (2010) (32)
- Thermostable β-glycosidase from Sulfolobus solfataricus (1994) (32)
- Structural basis for recruitment of BRCA2 by PALB2 (2017) (31)
- Electron microscopy of Xrcc4 and the DNA ligase IV-Xrcc4 DNA repair complex. (2009) (29)
- A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct (2016) (28)
- Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM (2019) (28)
- Crystal structure of the proximal BAH domain of the polybromo protein. (2005) (27)
- BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands (2018) (26)
- Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2 (2016) (26)
- Crystal structure of the Escherichia coli dcm very-short-patch DNA repair endonuclease bound to its reaction product-site in a DNA superhelix. (2003) (25)
- Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies (2011) (25)
- The BAH domain of Rsc2 is a histone H3 binding domain (2013) (24)
- Expression and crystallization of the yeast Hsp82 chaperone, and preliminary x‐ray diffraction studies of the amino‐terminal domain (1996) (24)
- In vitro inhibition of HIV‐1 proteinase by cerulenin (1990) (24)
- The high resolution structure of endothiapepsin (1985) (24)
- Recurrence of a binding motif? (1993) (23)
- Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90 (2011) (23)
- Assays for HSP90 and inhibitors. (2003) (23)
- Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint (2019) (23)
- Structural-thermodynamic relationships of interactions in the N-terminal ATP-binding domain of Hsp90. (2009) (23)
- Steric Hindrance Regulation of the Pseudomonas aeruginosa Amidase Operon* (2000) (22)
- Improving dideoxynucleotide-triphosphate utilisation by the hyper-thermophilic DNA polymerase from the archaeon Pyrococcus furiosus. (2000) (22)
- Electron microscopy studies on DNA recognition by DNA-PK. (2004) (22)
- Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting. (2012) (21)
- HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients (2017) (20)
- Targeting the Hsp90 molecular chaperone with novel macrolactams. Synthesis, structural, binding, and cellular studies. (2011) (20)
- Structure of the Ire 1 autophosphorylation complex and implications for the unfolded protein response (2011) (20)
- Letter to the Editor: Backbone resonance assignments of the 25kD N-terminal ATPase domain from the Hsp90 chaperone (2002) (20)
- Molecular Cloning and Expression of the Fabs of Human Autoantibodies in Escherichia coli (2000) (19)
- The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90 (2017) (19)
- Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1 (2010) (19)
- Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct (1998) (18)
- Cloning and expression of the uracil–DNA glycosylase inhibitor (UGI) from bacteriophage PBS‐1 and crystallization of a uracil–DNA glycosylase–UGI complex (1995) (17)
- Crystallization and preliminary X-ray analysis of the beta-galactosidase from the extreme thermophilic archaebacterium Sulfolobus solfataricus. (1993) (17)
- Expression of the Fabs of human auto-antibodies in Escherichia coli: optimization and determination of their fine binding characteristics and cross-reactivity. (2001) (17)
- Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies. (2010) (17)
- Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors (2014) (16)
- Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone (2020) (14)
- Structure of an Hsp 90-Cdc 37-Cdk 4 complex (2017) (14)
- Synthesis of a modified gene encoding human ornithine transcarbamylase for expression in mammalian mitochondrial and universal translation systems: a novel approach towards correction of a genetic defect. (1996) (14)
- Crystallization and preliminary crystallographic analysis of human alanine:glyoxylate aminotransferase and its polymorphic variants. (2001) (14)
- Structural and Functional Analysis of the Middle Segment of Hsp 90 : Implications for ATP Hydrolysis and Client (2003) (14)
- Molecular dynamics of alkylated DNA. (1992) (13)
- Tah1 helix-swap dimerization prevents mixed Hsp90 co-chaperone complexes (2014) (13)
- DNA repair in three dimensions. (1995) (13)
- The structure-function relationship of oncogenic LMTK3 (2020) (13)
- Energy calculations on aspartic proteinases: human renin, endothiapepsin and its complex with an angiotensinogen fragment analogue, H-142. (1985) (12)
- Advances on the Structure of the R2TP/Prefoldin-like Complex. (2018) (12)
- Crystallization and preliminary X-ray analysis of the uracil-DNA glycosylase DNA repair enzyme from herpes simplex virus type 1. (1993) (12)
- Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors (2015) (12)
- Crystallographic Studies of Reduced Bond Inhibitors Complexed with an Aspartic Proteinase (1987) (11)
- Erratum to: “Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors” [Biochim. Biophys. Acta 1697 (2004) 181–196] (2004) (11)
- Structural adaptation to selective pressure for altered ligand specificity in the Pseudomonas aeruginosa amide receptor, amiC. (2000) (10)
- Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1 (2021) (10)
- Similarity of active-site structures (1993) (9)
- Towards meeting the Paracelsus Challenge: The design, synthesis, and characterization of paracelsin-43, an alpha-helical protein with over 50% sequence identity to an all-beta protein. (1996) (9)
- Crystallization and preliminary X-ray analysis of an NAD(+)-dependent alcohol dehydrogenase from the extreme thermophilic archaebacterium Sulfolobus solfataricus. (1993) (9)
- ADP BINDING SITE IN THE HSP90 MOLECULAR CHAPERONE (1998) (9)
- Crystallization of and preliminary X-ray data for the negative regulator (AmiC) of the amidase operon of Pseudomonas aeruginosa. (1991) (9)
- Retroviral proteinases. A second front against AIDS. (1989) (9)
- Elimination of twinning in crystals of Sulfolobus sofataricus alcohol dehydrogenase holo-enzyme by growth in agarose gels. (1994) (8)
- CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle (2021) (8)
- Origins of stereospecificity in DNA damage by anti‐benzo[a]pyrene diol‐epoxides (1986) (8)
- Oligomerization of the amide sensor protein AmiC by x-ray and neutron scattering and molecular modeling. (1997) (7)
- THE ACTIVE SITE OF ACID PROTEINASES (1980) (7)
- Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein (2020) (6)
- The extended binding cleft of aspartic proteinases and its role in peptide hydrolysis (1985) (6)
- Expressed in yeast , human ERK 5 is a client of the Hsp 90 chaperone that complements loss of the Slt 2 ( Mpk 1 ) p cell integrity stress-activated protein kinase (2006) (6)
- Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein (2020) (6)
- Lupus autoantibodies to native DNA preferentially bind DNA presented on PolIV (2005) (6)
- Corrigendum to “Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2” [Bioorg. Med. Chem. 18 (2010) 707] (2010) (5)
- ATM Localization and Hete rochromatin Repair Depend on Direct Interaction of the 53 BP 1-BRCT 2 Domain with g H 2 AX Graphical Abstract Highlights (2015) (5)
- A combinatorial method to enable detailed investigation of protein-protein interactions. (2011) (5)
- Fine binding characteristics of human autoantibodies-partial molecular characterization. (2004) (5)
- Anti-cardiolipin/beta-2 glycoprotein activities co-exist on human anti-DNA antibody light chains. (2003) (5)
- Differential Regulation of G 1 CDK Complexes by the Hsp 90-Cdc 37 Chaperone System (2019) (4)
- Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches (2020) (4)
- PARP 3 is a sensor of nicked nucleosomes and monoribosylates histone H 2 (2019) (4)
- HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation (2022) (4)
- p185, an Immunodominant Epitope, Is an Autoantigen Mimotope* (2011) (4)
- Corrigendum: ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system (2013) (4)
- The 3D solution structure of the C-terminal region of Ku86 (2004) (3)
- Shared structural motif in proteins (1993) (3)
- Author Correction: RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex (2018) (3)
- The Mechanism of Dna Repair by Uracil-Dna Glycosylase: Studies Using Nucleotide Analogues (2000) (3)
- Modeling of a 14 kDa RUVBL2-Binding Domain with Medium Resolution Cryo-EM Density (2020) (3)
- Beta-2-glycoprotein specificity of human anti-phospholipid antibody resides on the light chain: a novel mechanism for acquisition of cross-reactivity by an autoantibody. (2005) (3)
- Structural basis of Hsp90 function (2013) (2)
- Structure of an Archaeal PCNA1-PCNA2-FEN1 Complex (2006) (2)
- Expression, purification and preliminary X-ray analysis of the BRCT domain from Rhp9/Crb2. (2003) (2)
- Structure of the human RAD17–RFC clamp loader and 9–1–1 checkpoint clamp bound to a dsDNA–ssDNA junction (2022) (2)
- Calculating CPK images on a UNIX workstation (1988) (2)
- Correction: In vitro Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors. (2019) (2)
- GLYCYL ENDOPEPTIDASE-COMPLEX WITH BENZYLOXYCARBONYL-LEUCINE-VALINE-GLYCINE-METHYLENE COVALENTLY BOUND TO CYSTEINE 25 (1995) (2)
- Functional analysis of the middle segment of Hsp90. (2003) (2)
- Yeast is selectively hypersensitised to Hsp90-targetting drugs with heterologous expression of the human Hsp90b, a property that can be exploited in screens for new Hsp90 chaperone inhibitors (2003) (2)
- Inhibition of aspartic proteinases by transition state substrate analogs. X-ray studies of the complex of endothiapepsin with the renin inhibitor H-142 (1985) (2)
- Molecular expression systems for anti-DNA antibodies—2 (2002) (1)
- HECTD 3 Mediates an HSP 90-Dependent Degradation Pathway for Protein Kinase Clients Graphical (2017) (1)
- Rac2 regulates its effector phospholipase C-gamma 2 through interaction with a split PH domain (2008) (1)
- Structure of a small molecule inhibitor with the kinase domain of Chk2 (2011) (1)
- Structure and function of the Rad 9 binding region of the DNA damage checkpoint adaptor (2019) (1)
- Crystal Structure of the Human Rad9-Rad1-Hus1 DNA Damage Checkpoint Complex (2009) (1)
- Non-productive MUG-DNA complex (2002) (1)
- Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2 (vol 18, pg 707, 2010) (2010) (1)
- Crystal structure of an Hsp90-Sba1 closed chaperone complex (2006) (1)
- Structure of alanine:glyoxylate aminotransferase (2002) (1)
- Structure and Evolution of Retroviral Proteinases (1989) (1)
- Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.Thislicens (2008) (1)
- High-resolution X-ray studies of the evolution, specificity and catalytic mechanism of acid proteinases (1981) (1)
- RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex (2018) (1)
- Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus (2022) (1)
- Letter to the Editor: Backbone 1H, 13C, and 15N resonance assignments for the C-terminal region of Ku86 (Ku86CTR) (2002) (1)
- Author response: Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint (2019) (1)
- Abstract C126: Molecular profiling of the HES transcription factor-TLE co-repressor protein-protein interaction site. (2011) (1)
- Is a Potent and Selective Inhibitor of CHK 2 that Potentiates the Cytotoxicity of PARP Inhibitors (2011) (1)
- Mechanism of action of a novel series of inhibitors of the Hsp90 molecular chaperone (2004) (1)
- SARS-CoV-2 variants of concern have acquired mutations associated with an 1 increased spike cleavage 2 (2021) (1)
- Crystal Structure of a PALB2 / BRCA2 complex (2009) (1)
- Cyclin-Cyclin-dependent Kinase Regulatory Response Is Linked to Substrate Recognition* (2011) (1)
- G:T/U MISMATCH-SPECIFIC DNA GLYCOSYLASE FROM E.COLI (1998) (1)
- Crystal structure of the human PARP-1 DNA binding domain in complex with DNA (2012) (1)
- CK2 phosphorylation of human papillomavirus 16 E2 on serine 23 promotes interaction with TopBP1 and is critical for E2 plasmid retention function (2021) (1)
- Abstract B99: Targeting TPR cochaperones of the Hsp90 molecular chaperone complex for specific inhibition. (2011) (0)
- Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2 in complex with a small molecule inhibitor (2016) (0)
- Crystal structure of CHK1 kinase domain in complex with a CLASPIN phosphopeptide (2021) (0)
- Crystal structure of the CHIP U-box E3 ubiquitin ligase (2005) (0)
- Rac2 (G12V) in complex with GTPgS (2009) (0)
- Crystal Structure of the FHA Domain of Human Polynucleotide Kinase 3' Phosphatase (2005) (0)
- Crystal structure of TOPBP1 BRCT0,1,2 in complex with a 53BP1 phosphopeptide (2019) (0)
- Co-crystal structure of a small molecule inhibitor bound to the kinase domain of Chk2 (2011) (0)
- STRUCTURE OF THE ORTHORHOMBIC FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE (1997) (0)
- Crystal structure of a MUG-DNA product complex (2002) (0)
- N-terminal domain of chicken (gallus gallus) PARP-3 (2016) (0)
- Crystal structure of the Human kinase and RNase domains in complex with ADP (2011) (0)
- HUMAN LYSOZYME MUTANT A96L COMPLEXED WITH CHITOTRIOSE (1998) (0)
- Abstract 4749: Insights into the molecular mechanism of HSP90 binding of methoxy-substituted resorcinylic isoxazole amide inhibitors reveal different isoform selectivity profiles (2012) (0)
- Native Structure of the Human 8-oxoguanine DNA Glycosylase hOGG1 (2002) (0)
- Mechanisms of stabilization of the β-glycosidase from the hyperthermophilic archaeon Sulfolobus solfataricus (1998) (0)
- A WRPW peptide bound to the Groucho-TLE WD40 domain. (2006) (0)
- crystal structure of the mouse CCT gamma apical domain (monoclinic) (2002) (0)
- Crystal structure of s.pombe Rad4 BRCT1,2 (2013) (0)
- Author Correction: RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex (2018) (0)
- Correction (2003) (0)
- A process for the preparation and identification of protein domains oplöselige (2002) (0)
- Human protein data: edited by André Haeberll, VCH, 1992. £103.00 ISBN 3 527 282114 (1993) (0)
- Generation of molecular dot-surfaces (1983) (0)
- Structural basis for the interaction of HSP90 with R2TP and TTT complexes (2014) (0)
- The structural basis for the coordination of Y-family Translesion DNA Polymerases by Rev1 (2013) (0)
- Crystal structure of coactivator-associated arginine methyltransferase 1 (CARM1), in complex with S-adenosyl-homocysteine (2007) (0)
- Crystal structure of human Chk2 in complex with ADP (2006) (0)
- 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint (2020) (0)
- NVP-AUY922, a novel diarylisoxazole resorcinol HSP90 inhibitor, potently inhibits growth and metastasis of human tumor xenografts (2007) (0)
- Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Inhibitor 7d (2012) (0)
- Crystal structure of coactivator-associated arginine methyltransferase 1 (CARM1), unliganded (2007) (0)
- Macrolactone Inhibitor bound to HSP90 N-term (2011) (0)
- AIP TPR domain in complex with human Tomm20 peptide (2013) (0)
- The BAH domain of Rsc 2 is a histone H 3 binding domain (2019) (0)
- Crystal structure of human Chk2 in complex with debromohymenialdisine (2006) (0)
- Inhibition of the HSP90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole, isoxazole amide analogs (2007) (0)
- Crystal structure of S.pombe Rad4 BRCT3,4 (2013) (0)
- Abstract 2677: A detailed analysis of protein binding and biological activity of methoxy-substituted resorcinylic isoxazole amide HSP90 inhibitors (2010) (0)
- Crystal structure of the human PNKP FHA domain in complex with an XRCC1-derived phosphopeptide (2009) (0)
- TopBP1 utilises a bipartite GINS binding mode to activate the replicative helicase (2023) (0)
- Author response: BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands (2018) (0)
- GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH 6-BROMOINDIRUBIN-3'-OXIME (2004) (0)
- HUMAN LYSOZYME DOUBLE MUTANT A96L, W109H (1998) (0)
- Crystal structure of the CHIP-UBC13-UEV1a complex (2005) (0)
- 3D Structure of DNA Repair Macromolecular Complexes Participating in Non-Homologous End-Joining (NHEJ) (2008) (0)
- NMR solution structure of phospholipase c epsilon RA 2 domain (2006) (0)
- Crystal structure of Rad4 BRCT1,2 in complex with a Sld3 phosphopeptide (2018) (0)
- Structure and Reaction Mechanism of the β-Glycosidase from the Archaeon Sulfolobus Solfataricus (1998) (0)
- X-ray structural studies of the aspartic proteinases (1984) (0)
- Edinburgh Research Explorer Visualization of a DNA-PK/PARP1 complex (2018) (0)
- Crystal structure of m2hTDP2-CAT in complex with a small molecule inhibitor (2016) (0)
- Structure of PLC epsilon Ras association domain with hRas (2006) (0)
- CHAPTER 2:Structural Basis of Hsp90 Function (2013) (0)
- Very-short-patch DNA repair endonuclease bound to its reaction product site (2003) (0)
- Spodoptera frugiperda eukaryotic translation initiation factor EIF5A (2016) (0)
- Middle Domain of HSP90 (2004) (0)
- Crystal Structure of a MUG-DNA pseudo substrate complex (2002) (0)
- COMPLEX OF HSP90 N-TERMINAL, SGT1 CS AND RAR1 CHORD2 DOMAIN (2010) (0)
- N-terminal BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands (2018) (0)
- Molecular cloning. Expression and functional evaluation of the recombinant Fabs of human anti-DNA (B3) and anti-cardiolipin (UK4) antibodies and their hybrids. (1999) (0)
- The applications of computer calligraphics in protein engineering and drug design (1984) (0)
- Radicicol analogues bound to the ATP site of HSP90 (2006) (0)
- X-ray crystal structure of human TNKS in complex with a small molecule inhibitor (2015) (0)
- Crystal structure of the proximal BAH domain of polybromo (2005) (0)
- Crystal structure of the C-terminal WD40 domain of human PALB2 (2009) (0)
- MDC 1 Interacts with TOPB P 1 to Maintain Chromosomal Stability during Mitosis Graphical (2019) (0)
- Hsp90 complexed with a resorcylic acid macrolactone. (2010) (0)
- Precursor-directed biosynthesis of macbecin analogues: generation of non-quinone containing Hsp90 inhibitors and pre-clinical evaluation (2008) (0)
- Xenopus SMUG1, an anti-mutator uracil-DNA Glycosylase (2003) (0)
- Crystal structure of TOPBP1 BRCT4,5 in complex with a 53BP1 phosphopeptide (2019) (0)
- Yeast Hsp90 N-terminal domain LI-IV mutant with Radicicol (2009) (0)
- Nucleic Acids Research (2010) (0)
- Yeast Hsp90 N-terminal domain LI-IV mutant with ADP (2009) (0)
- Yeast Hsp90 N-terminal domain LI-IV mutant with Geldanamycin (2009) (0)
- Complex of Rac2 and PLCg2 spPH Domain (2009) (0)
- Kinase domain of human Greatwall (2016) (0)
- GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH AXIN PEPTIDE (2003) (0)
- Crystal structure of CHK1 kinase domain in complex with ATPyS (2021) (0)
- Crystal structure of the BRCT domains of 53BP1 in complex with p53 and H2AX-pSer139 (gammaH2AX) (2015) (0)
- WD40 Region of Human Groucho/TLE1 (2002) (0)
- Crystal structure of Rad4 BRCT1,2 in complex with a Crb2 phosphopeptide (2013) (0)
- Crystal structure of the S.pombe Smc5/6 hinge domain (2017) (0)
- Cooperation of the PARP1 zinc-finger domains in recognising DNA strand breaks (2013) (0)
- Cleavage of RT/RNase H by HIV-1 Protease and Analysis of Substrate Cleavage Sites in vitro (1990) (0)
- The crystal structure of human alanine:glyoxylate aminotransferase (2003) (0)
- Crystal structure of the yeast Rsc2 BAH domain (2013) (0)
- Structure of the Crb2-BRCT2 domain complex with phosphopeptide. (2008) (0)
- Complex of Hsp90 N-terminal and Sgt1 CS domain (2008) (0)
- HUMAN LYSOZYME MUTANT A96L (1998) (0)
- Design and Discovery of 3-Aryl-5-Substituted-Isoquinolin-1-Ones as Potent and Selective Tankyrase Inhibitors (2015) (0)
- Analogues of radicicol bound to the ATP-binding site of Hsp90 (2006) (0)
- Structural characterization of 5-Aryl-4-(5-substituted-2-4- dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors. (2012) (0)
- The identification of novel Hsp90 inhibitors (2004) (0)
- Structure of a Hsp90 Inhibitor bound to the N-terminus of Yeast Hsp90. (2005) (0)
- Faculty Opinions recommendation of CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37. (2004) (0)
- STRUCTURE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE IN COMPLEX WITH GELDANAMYCIN (1998) (0)
- STRUCTURE OF THE TETRAGONAL FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE (1997) (0)
- Efficient Single-Strand Bre ak Repair Requires Binding to Both Poly ( ADP-Ribose ) and DNA by the Central BRCT Domain of XRCC 1 Graphical Abstract Highlights (2019) (0)
- Structure-function & folding investigations of metallothionein (1991) (0)
- Abstract 3503: CCT241533 is a novel, potent and selective inhibitor of CHK2 and potentiates the cellular effects of PARP inhibitors (2010) (0)
- PLCg2 Split Pleckstrin Homology (PH) Domain (2009) (0)
- Structure Of The Hsp90 Inhibitor 7-O-carbamoylpremacbecin Bound To The N- Terminus Of Yeast Hsp90 (2008) (0)
- Faculty Opinions recommendation of Closing the folding chamber of the eukaryotic chaperonin requires the transition state of ATP hydrolysis. (2003) (0)
- The Structure of the complex between Aha1 and HSP90 (2004) (0)
- Complex of beta-clamp processivity factor and little finger domain of PolIV (2003) (0)
- MEDI 351-Toward "best-in-class" Hsp90 inhibitors: Design, biosynthesis and preclinical profiles (2007) (0)
- Three-dimensional Structure and Evolution of HIV-1 Protease (1990) (0)
- AMIDE RECEPTOR/NEGATIVE REGULATOR OF THE AMIDASE OPERON OF PSEUDOMONAS AERUGINOSA (AMIC) COMPLEXED WITH BUTYRAMIDE (1996) (0)
- Computer graphics modelling of mouse and human renins based upon the high-resolution structure of endothiapepsin (1984) (0)
- Corrigendum: The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks (2015) (0)
- BETA-GLYCOSIDASE FROM SULFOLOBUS SOLFATARICUS (1997) (0)
- Structure of the Crb2-BRCT2 domain (2008) (0)
- A process for the production and identification of soluble protein domains (2002) (0)
- L89V, L93I and V136M Mutant of N-Term HSP90 complexed with Geldanamycin (2011) (0)
- Crystal structure of TOPBP1 BRCT0,1,2 in complex with a RAD9 phosphopeptide (2018) (0)
- Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2 (2016) (0)
- Cryo-EM structure of the TELO2-TTI1-TTI2-RUVBL1-RUVBL2 complex (2021) (0)
- Crystal structure ofAmiC:thecontroller of transcription antitermination intheamidase operon ofPseudomonas aeruginosa (1994) (0)
- Glycogen synthase kinase-3 inhibition by Li+ and Be2+ suggests the presence of two Mg2+ binding sites (2002) (0)
- RADICICOL BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE (1999) (0)
- E88G-N92L Mutant of N-Term HSP90 complexed with Geldanamycin (2011) (0)
- Apo solution structure of Hop TPR2A (2017) (0)
- Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Leucettine L4 (2013) (0)
- A molecular modelforproflavine-DNA intercalation (1988) (0)
- Crystal structure of Rad4 BRCT1,2 in complex with a Mdb1 phosphopeptide (2018) (0)
- CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR (2009) (0)
- STRUCTURE OF THE HSP90 INHIBITOR MACBECIN BOUND TO THE N-TERMINUS OF YEAST HSP90. (2008) (0)
- Structural Analysis of the Ruv AB Holliday Junction Branch Migration Complex (1999) (0)
- Amide receptor of the amidase operon of Pseudomonas aeruginosa (AmiC) complexed with the negative regulator AmiR. (1999) (0)
- Complex of Hsp90 and P50 (2004) (0)
- NMR solution structure of phospholipase c epsilon RA 1 domain (2006) (0)
- RUVA COMPLEXED TO A HOLLIDAY JUNCTION. (1998) (0)
- A RADICICOL ANALOGUE BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE (2006) (0)
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