Laurent Meijer
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Laurent Meijer's Degrees
- PhD Computer Science Université Paris Cité
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(Suggest an Edit or Addition)Laurent Meijer's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor (2004) (2174)
- Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. (1997) (1321)
- GSK-3-selective inhibitors derived from Tyrian purple indirubins. (2003) (773)
- Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. (1998) (761)
- Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases (1999) (740)
- Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine. (1997) (654)
- Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? (2001) (606)
- Pharmacological inhibitors of glycogen synthase kinase 3. (2004) (592)
- Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons (1999) (562)
- Pharmacological inhibitors of cyclin-dependent kinases. (2002) (508)
- cdc2 is a component of the M phase-specific histone H1 kinase: Evidence for identity with MPF (1988) (488)
- Constitutive Phosphorylation of the Parkinson's Disease Associated α-Synuclein* (2000) (437)
- Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. (2000) (371)
- Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. (2004) (349)
- Roscovitine Targets, Protein Kinases and Pyridoxal Kinase*[boxs] (2005) (347)
- Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25. (2000) (338)
- Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials. (2003) (279)
- Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity. (1999) (268)
- Synthesis, anti-inflammatory, analgesic and kinase (CDK-1, CDK-5 and GSK-3) inhibition activity evaluation of benzimidazole/benzoxazole derivatives and some Schiff's bases. (2006) (265)
- ATP-site directed inhibitors of cyclin-dependent kinases. (1999) (257)
- Multiple modes of ligand recognition: Crystal structures of cyclin‐dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine (1995) (238)
- Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein. (2000) (229)
- Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds. (1997) (226)
- Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors. (1999) (225)
- Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors. (2000) (225)
- Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. (1999) (219)
- Progress in Cell Cycle Research (1999) (213)
- Chemical inhibitors of cyclin-dependent kinases. (1996) (213)
- Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum. (2004) (184)
- Chemical inhibitors of cyclin-dependent kinases. (1997) (181)
- Mechanism of CDK5/p25 binding by CDK inhibitors. (2005) (171)
- Isolation of drugs active against mammalian prions using a yeast-based screening assay (2003) (171)
- Cyclin-dependent kinase inhibitors. (2003) (171)
- Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. (2012) (164)
- 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. (2004) (159)
- CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases (2008) (158)
- Olomoucine, an inhibitor of the cdc2/cdk2 kinases activity, blocks plant cells at the G1 to S and G2 to M cell cycle transitions (1994) (146)
- The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity. (1998) (145)
- Anti-mitotic properties of indirubin-3′-monoxime, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest (2001) (144)
- Sequential Dephosphorylation of p34cdc2 on Thr-14 and Tyr-15 at the Prophase/Metaphase Transition* (1996) (143)
- Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with Roscovitine, a novel cyclin-dependent kinase antagonist. (1997) (142)
- Cellular effects of olomoucine, an inhibitor of cyclin‐dependent kinases (1995) (141)
- Pfnek-1, a NIMA-related kinase from the human malaria parasite Plasmodium falciparum Biochemical properties and possible involvement in MAPK regulation. (2001) (139)
- Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. (2003) (137)
- Inhibition of Human Immunodeficiency Virus Type 1 Transcription by Chemical Cyclin-Dependent Kinase Inhibitors (2001) (136)
- Expression and activation of cdks (1 and 2) and cyclins in the cell cycle progression during liver regeneration. (1994) (133)
- Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex. (2008) (131)
- Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1. (2008) (126)
- Inhibitor binding to active and inactive CDK2: the crystal structure of CDK2-cyclin A/indirubin-5-sulphonate. (2001) (123)
- Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing. (2011) (120)
- Degradation of Hof1 by SCFGrr1 is important for actomyosin contraction during cytokinesis in yeast (2005) (120)
- Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors. (2004) (117)
- Synthesis and target identification of hymenialdisine analogs. (2004) (116)
- Intracellular Targets of Paullones (2002) (116)
- Cyclin-dependent kinases: initial approaches to exploit a novel therapeutic target. (1999) (115)
- Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model. (2008) (111)
- Anticancer Alkaloid Lamellarins Inhibit Protein Kinases (2008) (109)
- Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease (2001) (108)
- Pharmacological Cyclin-Dependent Kinase Inhibitors Inhibit Replication of Wild-Type and Drug-Resistant Strains of Herpes Simplex Virus and Human Immunodeficiency Virus Type 1 by Targeting Cellular, Not Viral, Proteins (2002) (108)
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. (2005) (106)
- The effect of the cyclin-dependent kinase inhibitor olomoucine on cell cycle kinetics. (1997) (106)
- Soluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period. (2008) (105)
- Antitumor and Hypoglycemic Activities of Polysaccharides from the Sclerotia and Mycelia of Inonotus obliquus (Pers.: Fr.) Pil. (Aphyllophoromycetideae) (1999) (103)
- Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor. (2006) (102)
- Inhibitors of Leishmania mexicana CRK3 Cyclin-Dependent Kinase: Chemical Library Screen and Antileishmanial Activity (2004) (101)
- Activation of a Plasmodium falciparum cdc2-related Kinase by Heterologous p25 and Cyclin H (2000) (101)
- Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins (2004) (100)
- Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases. (2007) (99)
- 7-Bromoindirubin-3′-oxime induces caspase-independent cell death (2006) (95)
- Synthesis of 3-substituted-2-oxoindole analogues and their evaluation as kinase inhibitors, anticancer and antiangiogenic agents. (2006) (95)
- Synthesis of acridinyl-thiazolino derivatives and their evaluation for anti-inflammatory, analgesic and kinase inhibition activities. (2005) (95)
- Roscovitine, a novel cyclin-dependent kinase inhibitor, characterizes restriction point and G2/M transition in tobacco BY-2 cell suspension. (1997) (94)
- Synthesis, protein kinase inhibitory potencies, and in vitro antiproliferative activities of meridianin derivatives. (2011) (92)
- Evaluation and comparison of 3D-QSAR CoMSIA models for CDK1, CDK5, and GSK-3 inhibition by paullones. (2004) (92)
- Delayed Treatment with Systemic (S)-Roscovitine Provides Neuroprotection and Inhibits In Vivo CDK5 Activity Increase in Animal Stroke Models (2010) (91)
- Synthesis of novel 5-substituted indirubins as protein kinases inhibitors. (2006) (87)
- Antimalarial drug discovery: targeting protein kinases (2007) (83)
- Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics. (2002) (80)
- Properties and potential-applications of chemical inhibitors of cyclin-dependent kinases. (1999) (80)
- Targeting cyclin-dependent kinases in anti-neoplastic therapy. (2013) (80)
- Cyclin-dependent kinase inhibition by new C-2 alkynylated purine derivatives and molecular structure of a CDK2-inhibitor complex. (2000) (79)
- Synthesis and biological evaluation of novel phenylcarbazoles as potential anticancer agents. (2006) (78)
- Inverse in silico screening for identification of kinase inhibitor targets. (2007) (77)
- Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class. (2012) (77)
- Protein kinases as drug targets in parasitic protozoa. (2002) (77)
- Antimalarial potential of xestoquinone, a protein kinase inhibitor isolated from a Vanuatu marine sponge Xestospongia sp. (2006) (76)
- Intra-M Phase-promoting Factor Phosphorylation of Cyclin B at the Prophase/Metaphase Transition* (1999) (75)
- 10-Iodo-11H-indolo[3,2-c]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A (2015) (75)
- Crystal Structure of Pyridoxal Kinase in Complex with Roscovitine and Derivatives* (2005) (74)
- Synthesis and anticancer activity of new pyrrolocarbazoles and pyrrolo-β-carbolines (2005) (73)
- 9-cyano-1-azapaullone (cazpaullone), a glycogen synthase kinase-3 (GSK-3) inhibitor activating pancreatic beta cell protection and replication. (2008) (72)
- CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells. (2010) (72)
- Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors. (2009) (71)
- Indirubin, the red shade of indigo (2006) (71)
- Cyclin-dependent kinase inhibitor indirubin-3′-oxime selectively inhibits human papillomavirus type 16 E7-induced numerical centrosome anomalies (2004) (71)
- Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins. (2009) (70)
- 6-Br-5methylindirubin-3'oxime (5-Me-6-BIO) targeting the leishmanial glycogen synthase kinase-3 (GSK-3) short form affects cell-cycle progression and induces apoptosis-like death: exploitation of GSK-3 for treating leishmaniasis. (2009) (70)
- 3'-Substituted 7-halogenoindirubins, a new class of cell death inducing agents. (2006) (67)
- Cyclin E-cdk2 phosphorylation promotes late G1-phase degradation of MyoD in muscle cells. (2000) (66)
- CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome (2013) (66)
- p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol (2002) (64)
- Modular asymmetric synthesis of aigialomycin D, a kinase-inhibitory scaffold. (2006) (63)
- Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis. (2004) (63)
- Purification of CK1 by affinity chromatography on immobilised axin. (2007) (63)
- Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue. (2009) (62)
- A Novel Interaction Between HER2/neu and Cyclin E in Breast Cancer (2010) (62)
- Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases (2012) (59)
- TRPC6 channel translocation into phagosomal membrane augments phagosomal function (2015) (58)
- Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases. (2005) (58)
- CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD (2012) (58)
- 2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity. (2000) (57)
- Cyclin-dependent kinase inhibitors: a survey of recent patent literature (2010) (56)
- Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: synthesis, biological evaluation and molecular modeling studies. (2008) (56)
- Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents. (2012) (56)
- Roscovitine and Other Purines as Kinase Inhibitors. From Starfish Oocytes to Clinical Trials (2003) (55)
- An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins. (2007) (55)
- Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum. (2001) (55)
- CDK/GSK-3 inhibitors as therapeutic agents for parenchymal renal diseases. (2008) (54)
- Identification of intracellular targets of small molecular weight chemical compounds using affinity chromatography (2007) (53)
- CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells (2014) (53)
- Thiazolo[5,4-f]quinazolin-9-ones, inhibitors of glycogen synthase kinase-3. (2006) (52)
- Cyclin-dependent kinases inhibitors as potential anticancer, antineurodegenerative, antiviral and antiparasitic agents. (2000) (52)
- Purine‐Based Inhibitors of Inositol‐1,4,5‐trisphosphate‐3‐kinase (2002) (51)
- Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A (2018) (51)
- Cdk2 is required for breast cancer mediated by the low-molecular-weight isoform of cyclin E. (2011) (50)
- Structure-based design modifications of the paullone molecular scaffold for cyclin-dependent kinase inhibition. (2000) (50)
- Synthesis of 3,5-bis(2-indolyl)pyridine and 3-[(2-indolyl)-5-phenyl]pyridine derivatives as CDK inhibitors and cytotoxic agents. (2008) (50)
- Synthesis and in vitro evaluation of novel 2,6,9-trisubstituted purines acting as cyclin-dependent kinase inhibitors. (1999) (49)
- Low molecular weight cyclin E is specific in breast cancer and is associated with mechanisms of tumor progression (2009) (49)
- 3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3. (2013) (48)
- Plasmodium falciparum NIMA-related kinase Pfnek-1: sex specificity and assessment of essentiality for the erythrocytic asexual cycle (2011) (48)
- Synthesis and kinase inhibitory activity of novel substituted indigoids. (2009) (47)
- Butyrolactone I derivatives from Aspergillus terreus carrying an unusual sulfate moiety. (2008) (46)
- N-&-N, a new class of cell death-inducing kinase inhibitors derived from the purine roscovitine (2008) (45)
- Coscinosulfate, a CDC25 phosphatase inhibitor from the sponge Coscinoderma mathewsi. (2001) (45)
- Human cells enter mitosis with damaged DNA after treatment with pharmacological concentrations of genotoxic agents (2012) (45)
- (R)-roscovitine (CYC202, Seliciclib) sensitizes SH-SY5Y neuroblastoma cells to nutlin-3-induced apoptosis. (2006) (45)
- A S/M DNA replication checkpoint prevents nuclear and cytoplasmic events of cell division including centrosomal axis alignment and inhibits activation of cyclin-dependent kinase-like proteins in fucoid zygotes. (2000) (44)
- Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors. (2012) (44)
- Acridone alkaloids from Glycosmis chlorosperma as DYRK1A inhibitors. (2014) (43)
- Design and Synthesis of Thiazolo[5,4-f]quinazolines as DYRK1A Inhibitors, Part I (2014) (41)
- Novel tetrahydropyrido[1,2-a]isoindolone derivatives (valmerins): potent cyclin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts. (2012) (41)
- Pharmacological Assessment Defines Leishmania donovani Casein Kinase 1 as a Drug Target and Reveals Important Functions in Parasite Viability and Intracellular Infection (2013) (41)
- Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature (2017) (41)
- Synthesis, resolution, and biological evaluation of atropisomeric (aR)- and (aS)-16-methyllamellarins N: unique effects of the axial chirality on the selectivity of protein kinases inhibition. (2013) (39)
- Indirubin derivative 6BIO suppresses metastasis. (2013) (39)
- Allene oxide and aldehyde biosynthesis in starfish oocytes. (1991) (39)
- Synthesis of C2 alkynylated purines, a new family of potent inhibitors of cyclin-dependent kinases. (1998) (39)
- Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis (2016) (38)
- Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis (2016) (38)
- Synthesis and optimization of an original V-shaped collection of 4-7-disubstituted pyrido[3,2-d]pyrimidines as CDK5 and DYRK1A inhibitors. (2014) (38)
- Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents. (2011) (38)
- Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases. (2013) (38)
- Polyprenyl-hydroquinones and -furans from three marine sponges inhibit the cell cycle regulating phosphatase CDC25A (2004) (38)
- Identifying in vivo targets of cyclin-dependent kinase inhibitors by affinity chromatography. (2002) (38)
- Targeting low molecular weight cyclin E (LMW-E) in breast cancer (2012) (37)
- Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes. (2005) (37)
- Structure‐Aided Optimization of Kinase Inhibitors Derived from Alsterpaullone (2005) (37)
- Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular modelling. (2013) (37)
- Antiinflammatory, analgesic and kinase inhibition activities of some acridine derivatives (2004) (36)
- Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1. (2000) (36)
- From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity (2016) (36)
- Synthesis and molecular modelling studies of 8-arylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amines as multitarget Ser/Thr kinases inhibitors. (2015) (36)
- Identification and structure-activity relationship of 8-hydroxy-quinoline-7-carboxylic acid derivatives as inhibitors of Pim-1 kinase. (2010) (35)
- Biosynthesis of New Indigoid Inhibitors of Protein Kinases Using Recombinant Cytochrome P450 2A6 (2005) (35)
- Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors. (2002) (34)
- Characterization of two T. gondii CK1 isoforms. (2005) (33)
- Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. (2016) (33)
- Epoxide-containing side chains enhance antiproliferative activity of paullones. (2005) (33)
- Cyclin-dependent kinase inhibitors closer to market launch? (2013) (33)
- 9- and 11-Substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma. (2014) (32)
- Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors (2005) (32)
- (R)-Roscovitine (CYC202, Seliciclib) (2006) (31)
- Inhibition of NF-κB–Mediated Signaling by the Cyclin-Dependent Kinase Inhibitor CR8 Overcomes Prosurvival Stimuli to Induce Apoptosis in Chronic Lymphocytic Leukemia Cells (2013) (30)
- Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors. (2010) (30)
- Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases (2017) (30)
- A western blot assay to measure cyclin dependent kinase activity in cells or in vitro without the use of radioisotopes (2013) (29)
- Library-based Discovery of DYRK1A/CLK1 Inhibitors from Natural Product Extracts (2012) (29)
- Progress in Cell Cycle Research (1995) (29)
- Synthesis, biological evaluation, and molecular modeling of natural and unnatural flavonoidal alkaloids, inhibitors of kinases. (2012) (28)
- 1‐Azakenpaullone Is a Selective Inhibitor of Glycogen Synthase Kinase‐3β. (2004) (28)
- Intracellular targets of paullones: identification following affinity purification on immobilized inhibitor (2002) (28)
- Exploration of the imidazo[1,2-b]pyridazine scaffold as a protein kinase inhibitor. (2017) (28)
- A one-pot synthesis and biological activity of ageladine A and analogues. (2011) (27)
- Dual-Specificity, Tyrosine Phosphorylation-Regulated Kinases (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an Overview (2021) (27)
- Chloromethylhalicyclamine B, a Marine-Derived Protein Kinase CK1δ/ε Inhibitor. (2016) (27)
- Inhibition of Tat-mediated HIV-1 replication and neurotoxicity by novel GSK3-beta inhibitors. (2011) (27)
- Diversity of the intracellular mechanisms underlying the anti-tumor properties of indirubins (2007) (27)
- Roscovitine is a proteostasis regulator that corrects the trafficking defect of F508del‐CFTR by a CDK‐independent mechanism (2014) (27)
- Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure. (2016) (25)
- Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice (2019) (25)
- cdc-Like/Dual-Specificity Tyrosine Phosphorylation–Regulated Kinases Inhibitor Leucettine L41 Induces mTOR-Dependent Autophagy: Implication for Alzheimer’s Disease (2014) (25)
- In Vitro Activities of Two Antimitotic Compounds, Pancratistatin and 7-Deoxynarciclasine, againstEncephalitozoon intestinalis, a Microsporidium Causing Infections in Humans (2001) (24)
- Dispacamide E and other bioactive bromopyrrole alkaloids from two Indonesian marine sponges of the genus Stylissa (2015) (24)
- CDK/GSK-3 inhibitors as a new approach for the treatment of proliferative renal diseases. (2006) (24)
- Access to Paullone Analogues by Intramolecular Heck Reaction (2007) (24)
- Use of ATP analogs to inhibit HIV-1 transcription. (2012) (23)
- Development of 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters as selective inhibitors of mitochondrial malate dehydrogenase (mMDH). (2010) (23)
- CDK1‐Inhibitory Activity of Paullones Depends on Electronic Properties of 9‐Substituents (2004) (23)
- Towards the syntheses of N-H and N-alkylated derivatives of meridianins (2007) (23)
- Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors. (2009) (22)
- Synthesis of Paullones with Aminoalkyl Side Chains (2002) (22)
- 7-Bromoindirubin-3'-oxime uncovers a serine protease-mediated paradigm of necrotic cell death. (2008) (22)
- microRNA machinery is an integral component of drug-induced transcription inhibition in HIV-1 infection (2010) (22)
- Practical Synthesis of Roscovitine and CR8 (2009) (22)
- Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles as PI3Kα inhibitors. (2012) (21)
- Inhibition of cyclin‐dependent kinases induces differentiation of supernumerary hair cells and Deiters' cells in the developing organ of Corti (2003) (21)
- Impact of meriolins, a new class of cyclin-dependent kinase inhibitors, on malignant glioma proliferation and neo-angiogenesis. (2014) (21)
- Starfish oocyte maturation: from prophase to metaphase (1994) (21)
- Novel Mouse Tauopathy Model for Repetitive Mild Traumatic Brain Injury: Evaluation of Long-Term Effects on Cognition and Biomarker Levels After Therapeutic Inhibition of Tau Phosphorylation (2019) (21)
- Natural Aristolactams and Aporphine Alkaloids as Inhibitors of CDK1/Cyclin B and DYRK1A (2013) (21)
- Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides. (2018) (21)
- Chemical synthesis and biological validation of immobilized protein kinase inhibitory Leucettines. (2013) (21)
- Evaluation of the first cytostatically active 1-aza-9-oxafluorenes as novel selective CDK1 inhibitors with P-glycoprotein modulating properties. (2003) (20)
- Functional genomics identify Birc5/Survivin as a candidate gene involved in the chronotoxicity of cyclin-dependent kinase inhibitors (2014) (20)
- Synthesis and biological evaluation of analogs of the marine alkaloids granulatimide and isogranulatimide. (2012) (20)
- Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25. (2011) (19)
- Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype (2018) (19)
- A Cdk5 inhibitor enhances the induction of insulin secretion by exendin-4 both in vitro and in vivo. (2007) (19)
- Several Human Cyclin-Dependent Kinase Inhibitors, Structurally Related to Roscovitine, As New Anti-Malarial Agents (2014) (18)
- Synthesis of novel 7-substituted pyrido[2',3':4,5]furo[3,2-d]pyrimidin-4-amines and their N-aryl analogues and evaluation of their inhibitory activity against Ser/Thr kinases. (2013) (18)
- 5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms. (2016) (18)
- Concise synthesis and CDK/GSK inhibitory activity of the missing 9-azapaullones. (2010) (18)
- Phenanthrene derivatives from Appendicula reflexa as new CDK1/cyclin B inhibitors (2012) (18)
- Aβ-42 lowering agents from the marine-derived fungus Dichotomomyces cejpii (2015) (18)
- The pleiotropic profile of the indirubin derivative 6BIO overcomes TRAIL resistance in cancer. (2014) (17)
- Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease? (2013) (17)
- Rebeccamycin Derivatives as Dual DNA-Damaging Agents and Potent Checkpoint Kinase 1 Inhibitors (2008) (17)
- Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp. (2015) (17)
- Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design (2018) (17)
- A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment (2020) (16)
- ATP-site Directed Inhibitors of Cyclin-dependent Kinases (1999) (15)
- Imidazo[2,1 -b]thiazolylmethylene- and indolylmethylene-2-indolinones: a new class of cyclin-dependent kinase inhibitors. Design, synthesis, and CDK1/cyclin B inhibition. (2000) (15)
- Advances in tetrahydropyrido[1,2-a]isoindolone (valmerins) series: Potent glycogen synthase kinase 3 and cyclin dependent kinase 5 inhibitors. (2015) (15)
- Replication-Dependent DNA Damage Response Triggered by Roscovitine Induces an Uncoupling of DNA Replication Proteins (2006) (15)
- Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors. (2014) (15)
- Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death (2018) (15)
- Indirubins deplete striatal monoamines in the Intact and MPTP-treated mouse brain and block kainate-induced striatal astrogliosis. (2010) (15)
- Small‐molecule inducers of Aβ‐42 peptide production share a common mechanism of action (2012) (15)
- Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives. (2016) (14)
- Synthesis, biological evaluation and molecular modelling studies of 4-anilinoquinazoline derivatives as protein kinase inhibitors. (2014) (14)
- Chemical inhibitors of cyclin-dependent kinases. (1995) (14)
- Screening the active constituents of Chinese medicinal herbs as potent inhibitors of Cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34cdc2 kinase. (2005) (14)
- Synthesis and biological evaluation of new penta- and heptacyclic indolo- and quinolinocarbazole ring systems obtained via Pd(0) catalysed reductive N-heteroannulation. (2010) (14)
- Catalyst-free synthesis of quinazolin-4-ones from (hetero)aryl-guanidines: application to the synthesis of pyrazolo[4,3-f]quinazolin-9-ones, a new family of DYRK1A inhibitors (2012) (14)
- An efficient approach to dispacamide A and its derivatives. (2012) (14)
- Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors. (2016) (13)
- The Cyclin-Dependent Kinase (cdk) Inhibitors, Olomoucine and Roscovitine, Alter the Expression of a Molluscan Circadian Pacemaker (1997) (13)
- Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases (2016) (13)
- (R)-Roscovitine and CFTR modulators enhance killing of multi-drug resistant Burkholderia cenocepacia by cystic fibrosis macrophages (2020) (13)
- A Pd(0) based cross-coupling approach to the synthesis of 2-amidopurines and their evaluation as CDK inhibitors. (2007) (13)
- Specific Triazine Herbicides Induce Amyloid-β42 Production. (2016) (13)
- [b]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors (2019) (12)
- Synthesis of New N,N’-Bis(5-arylidene-4-oxo-4,5-dihydrothiazolin-2-yl)piperazine Derivatives Under Microwave Irradiation and Preliminary Biological Evaluation (2012) (12)
- [Chemical inhibitors of cyclic-dependent kinases: preclinical and clinical study]. (2000) (12)
- Synthesis of a new series of purine derivatives and their anti‐cyclin‐dependent kinase activities (2001) (11)
- An efficient method for the preparation of new analogs of leucettamine B under solvent-free microwave irradiation (2009) (11)
- Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models (2019) (11)
- Erratum to: “Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors” [Biochim. Biophys. Acta 1697 (2004) 181–196] (2004) (11)
- Expression and Activity of Cyclin-Dependent Kinases and Glycogen Synthase Kinase-3 during NT2 Neuronal Differentiation (2004) (11)
- New 5-ylidene rhodanine derivatives based on the dispacamide A model (2014) (11)
- Harnessing Neutrophil Survival Mechanisms during Chronic Infection by Pseudomonas aeruginosa: Novel Therapeutic Targets to Dampen Inflammation in Cystic Fibrosis (2017) (11)
- Intracellular targets of paullones : identification by affinity chromatography using immobilized inhibitor. (2002) (11)
- Synthesis of N,N'-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl)diamines bearing various linkers and biological evaluation as potential inhibitors of kinases. (2012) (11)
- Synthesis and biological evaluation of selective and potent cyclin-dependent kinase inhibitors. (2012) (10)
- Suzuki-type Pd(0) coupling reactions in the synthesis of 2-arylpurines as Cdk inhibitors. (2006) (10)
- Synthesis and biological evaluation of tetrahydro[1,4]diazepino[1,2-a]indol-1-ones as cyclin-dependent kinase inhibitors. (2014) (10)
- Biological Characterization of 8-Cyclopropyl-2-(pyridin-3-yl)thiazolo[5,4-f]quinazolin-9(8H)-one, a Promising Inhibitor of DYRK1A (2019) (10)
- 8-Dimethylamino-1-methyladenine, a novel potent antagonist of the 1-methyladenine receptor in starfish oocytes. (1993) (10)
- An Overview of In Vivo and In Vitro Models for Autosomal Dominant Polycystic Kidney Disease: A Journey from 3D-Cysts to Mini-Pigs (2020) (10)
- Synthesis and evaluation of new potent inhibitors of CK1 and CDK5, two kinases involved in Alzheimer’s disease (2013) (9)
- Synthesis and Biological Evaluation of Thienopyrrolizines, a New Family of CDK/GSK-3 Inhibitors (2004) (9)
- Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice (2013) (9)
- Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors. (2016) (9)
- The Paullones: A Family of Pharmacological Inhibitors of Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 (2005) (8)
- Purine-Based Inhibitors of Inositol1,4,5-trisphosphate-3-kinase (2010) (8)
- A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives (2011) (7)
- Long-Term Fipronil Treatment Induces Hyperactivity in Female Mice (2020) (7)
- Evaluation of CDK Inhibitor Selectivity: From Affinity Chromatography to Yeast Genetics (2006) (7)
- Molecular cloning and characterisation of p15(CDK-BP), a novel CDK-binding protein. (2002) (7)
- A facile consensus ranking approach enhances virtual screening robustness and identifies a cell-active DYRK1α inhibitor. (2018) (7)
- 1,4,5-trisphosphate-3-kinase (2002) (7)
- N-(1H-Pyrazol-3-yl)quinazolin-4-amines as a novel class of casein kinase 1δ/ε inhibitors: Synthesis, biological evaluation and molecular modeling studies. (2017) (7)
- Development of Kinase Inhibitors via Metal-Catalyzed C–H Arylation of 8-Alkyl-thiazolo[5,4-f]-quinazolin-9-ones Designed by Fragment-Growing Studies (2018) (6)
- Photoreactivity of indirubin derivatives. (2008) (6)
- Characterization of the cell death processes triggered by indirubin derivatives in neuroblastoma cells (2006) (6)
- Synthesis of Bioactive 2-(Arylamino)thiazolo[5,4-f]-quinazolin-9-ones via the Hügershoff Reaction or Cu- Catalyzed Intramolecular C-S Bond Formation (2016) (6)
- Characterization of a novel cdk1-related kinase. (1999) (6)
- Identification of potential cellular targets of aloisine A by affinity chromatography. (2009) (6)
- Involvement of RB kinases and phosphatases in life and death decisions. (1997) (6)
- Therapeutics , Targets , and Chemical Biology Indirubin Derivative 6 BIO Suppresses Metastasis (2013) (6)
- A Collection of Bioactive Nitrogen-Containing Molecules from the Marine Sponge Acanthostrongylophora ingens (2019) (5)
- Combined Virtual and Experimental Screening for CK1 Inhibitors Identifies a Modulator of p53 and Reveals Important Aspects of in Silico Screening Performance (2017) (5)
- Palladium-Catalyzed Synthesis of Substituted Pyrido[2,3-d]pyridazines at Positions 5 and 8 (2012) (5)
- A Simple Isomerization of the Purine Scaffold of a Kinase Inhibitor, Roscovitine, Affords a Four- to Seven-Fold Enhancement of Its Affinity for Four CDKs. Could This Be Traced Back to Conjugation-Induced Stiffenings/Loosenings of Rotational Barriers? (2017) (5)
- An expeditious, environment-friendly, and microwave-assisted synthesis of 5-isatinylidenerhodanine derivatives (2011) (5)
- Synthesis of 6-Pyridylaminopurines (2008) (4)
- Editorial: Role of cyclin‐dependent kinase‐5 (Cdk5) in the central nervous system (2007) (4)
- Exploring Kinase Inhibition Properties of 9H-pyrimido[5,4-b]- and [4,5-b]indol-4-amine Derivatives (2020) (4)
- Discovery of the first potent and selective inhibitors of the human dCTP pyrophosphatase 1 (dCTPase) (2016) (4)
- [Cell cycle and molecular targets: CDK inhibition]. (2012) (4)
- Safety and pharmacokinetics of Roscovitine (Seliciclib) in cystic fibrosis patients chronically infected with Pseudomonas aeruginosa, a randomized, placebo-controlled study. (2021) (4)
- AUTHOR AGREEMENT FORM Manuscript title: “5-Me-6-BIO targeting the leishmanial GSK-3 short form affects cell-cycle progression and induces apoptosis-like death: exploitation of GSK-3 for treating leishmaniasis” (2009) (4)
- Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors. (2021) (4)
- Genetic Impairment of Succinate Metabolism Disrupts Bioenergetic Sensing in Adrenal Neuroendocrine Tumor (2022) (4)
- Microwave Assisted Organic Synthesis (MAOS) of New Dispacamide A Derivatives Bearing a Thiazolinone Platform, Biological Assays on Inhibition of Protein Kinases and Cell Effects (2013) (3)
- ePS03.7 Rosco-CF, a safety and efficacy clinical trial of (R)-roscovitine in CF patients (2016) (3)
- Decrease in p3-Alcβ37 and p3-Alcβ40, products of Alcadein β generated by γ-secretase cleavages, in aged monkeys and patients with Alzheimer's disease (2019) (3)
- In vitro Activity of Antimitotic Compounds Against the Microsporidium Encephalitozoon intestinalis (2001) (3)
- Crystal Structure of human CDC-like kinase 3 isoform in complex with leucettine L41 (2011) (3)
- [Prevention of chemotherapy-induced alopecia by cyclin-dependant kinase inhibitors]. (2001) (3)
- Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8. (2018) (3)
- Towards the Syntheses of N—H and N-Alkylated Derivatives of Meridianins. (2007) (3)
- The cell division cycle and its regulation (2006) (3)
- Synthesis and anticancer activity of new pyrrolocarbazoles and pyrrolo-beta-carbolines. (2005) (3)
- Antitumoral effects of cyclin-dependent kinases inhibitors CR8 and MR4 on chronic myeloid leukemia cell lines (2015) (3)
- Design and Microwave Synthesis of New (5Z) 5-Arylidene-2-thioxo-1,3-thiazolinidin-4-one and (5Z) 2-Amino-5-arylidene-1,3-thiazol-4(5H)-one as New Inhibitors of Protein Kinase DYRK1A (2021) (3)
- [Mediterranean purple indirubins: a source of GSK-3 inhibitors]. (2004) (2)
- ChemInform Abstract: Pyrazolo[3,4-b]quinoxalines. A New Class of Cyclin-Dependent Kinases Inhibitors (2002) (2)
- 2‐Substituted Paullones: CDK1/Cyclin B‐Inhibiting Property and in vitro Antiproliferative Activity. (2000) (2)
- The protein kinase CK1: Inhibition, activation, and possible allosteric modulation (2022) (2)
- Development, Selectivity, and Application of Paullones, a Family of CDK Inhibitors (2006) (2)
- Erratum to: microRNA machinery is an integral component of drug-induced transcription inhibition in HIV-1 infection (2010) (2)
- Exploring the Synthesis of New 1-(4-Substitutedphenylamino) imidazo(1,5-a)indol-3-one Derivatives as Cyclized Analogs of Leucettines (2014) (2)
- Second International Electronic Conference on Medicinal Chemistry (ECMC-2) (2017) (2)
- In Vitro Evaluation of a Novel 2,6,9‐Trisubstituted Purine Acting As a Cyclin‐Dependent Kinase Inhibitor (1999) (2)
- , 4-f ] quinazolin-9 ( 8 H )-one Backbone : Synthesis of an Array of Potential Kinase Inhibitors (2017) (2)
- Author Correction: A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment (2020) (2)
- Synthesis of a New Series of Purine Derivatives and Their Anti-Cyclin-Dependent Kinase Activities. (2001) (2)
- Synthesis of Paullones with Aminoalkyl Side Chains. (2002) (2)
- An Efficient Method for the Preparation of New Analogues of Leucettamine B under Solvent‐Free Microwave Irradiation. (2009) (1)
- Non-Linear Pharmacokinetics of Oral Roscovitine (Seliciclib) in Cystic Fibrosis Patients Chronically Infected with Pseudomonas aeruginosa: A Study on Population Pharmacokinetics with Monte Carlo Simulations (2020) (1)
- Synthesis of 6‐Pyridylaminopurines. (2008) (1)
- Inhibitors of Protein Kinases and Protein Phosphates Contributors (2005) (1)
- Starfish Oocytes and Sea Urchin Eggs as Models to Study the Intracellular Mechanisms Controlling the Cell Division Cycle (1990) (1)
- WS14.1 ROSCO-CF, a safety and efficacy clinical trial of (R)-roscovitine in cystic fibrosis patients (2018) (1)
- Cosimo, Emilio et al. (2014) Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes pro-survival stimuli to induce apoptosis in chronic lymphocytic leukemia cells. Clinical Cancer (2013) (1)
- Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice (2013) (1)
- Leucettines, a family of pharmacological inhibitors of DYRKs & CLKs kinases derived from the marine sponge Leucettamine B (2012) (1)
- Suzuki‐Type Pd(0) Coupling Reactions in the Synthesis of 2‐Arylpurines as Cdk Inhibitors. (2006) (1)
- Novel 9‐Oxo‐thiazolo[5,4‐f]quinazoline‐2‐carbonitrile Derivatives as Dual Cyclin‐Dependent Kinase 1 (CDK1)/Glycogen Synthase Kinase‐3 (GSK‐3) Inhibitors: Synthesis, Biological Evaluation and Molecular Modeling Studies. (2008) (1)
- [Search for natural substances with therapeutic activity: George R. Pettit]. (2014) (1)
- Pharmacoproteomic and toxicoproteomic study of the natural product Ebenfuran III in DU-145 prostate cancer cells using iTRAQ with 2D LC and tandem mass spectrometry (2008) (1)
- Identification of CLK1 Inhibitors by a Fragment–linking Based Virtual Screening (2017) (1)
- Versatile selective kinase inhibitors: Chemistry and biology of indirubins (2012) (1)
- [Search for natural substances with therapeutic activity: Pierre Potier (1934-2006)]. (2012) (1)
- 134 Rationale for evaluating (R)-roscovitine (Seliciclib) in patients with cystic fibrosis (2015) (1)
- Progress in Cell Cycle Research (2000) (0)
- Use of (S) -roscovitine for the manufacture of a medicament (2006) (0)
- Cyclin-dependent kinase inhibitors: New compounds, selectivity, mechanisms of action and anti-proliferative activities (2001) (0)
- Synthesis of New Dipyrrolo‐ and Furopyrrolopyrazinones Related to Tripentones and Their Biological Evaluation as Potential Kinases (CDKs1—5, GSK‐3) Inhibitors. (2009) (0)
- Compounds ° pyrrolo 2,3-b! Pyridine compounds useful azaindole in the synthesis of these compounds ° pyrrolo 2,3-b! Pyridine their processes of manufacture and their uses. (2007) (0)
- Antitumoral effects of cyclin-dependent kinases inhibitors CR8 and MR4 on chronic myeloid leukemia cell lines (2015) (0)
- Leucettines, a family of pharmacological inhibitors of DYRKs and CLKs derived from the marine sponge: Natural product Leucettamine B (2012) (0)
- Synthesis and kinases inhibitory potencies of aminopyrimidyl-indole derivatives (2009) (0)
- LMW cyclin E and its novel catalytic partner CDK5 are therapeutic targets and prognostic biomarkers in salivary gland cancers (2021) (0)
- Catalyst-free synthesis of quinazolin-4-ones from (hetero)aryl-guanidines: application to the synthesis of pyrazolo[4,3-f]quinazolin-9-ones, a new family of DYRK1A inhibitors (2012) (0)
- Crystal structure of human CLK1 in complex with pyrido[3,4-g]quinazoline derivative ZW29 (compound 13) (2016) (0)
- Crystal structure of human CDK2 in complex with the inhibitor olomoucine. (2005) (0)
- Author Correction: A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment (2020) (0)
- Abstract LB-C04: Phosphoproteomics unravels dynamic regulation of energy sensor by CDK5 in Neuroendocrine Tumor (2019) (0)
- Synthesis of C2 Alkynylated Purines, a New Family of Potent Inhibitors of Cyclin‐Dependent Kinases. (1998) (0)
- Cyclin-Dependent Kinases (CDKs) in human disease: the therapeutic potential of pharmacological inhibitors (2008) (0)
- SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW PYRIDINE AND PYRAZINE BIS-ARYL DERIVATIVES (2008) (0)
- Human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and Leucettine L41 (2012) (0)
- P.1.c.014 Inhibition of DYRK1A overdosage restores cognition in Down syndrome models through DYRK1A-interaction with major players of synaptic transmission (2017) (0)
- Purinederivate with antipoliferativer effective and their biological properties (1996) (0)
- Roscovitine: a novel corrector for the functional rescue of F508del-CFTR protein (2009) (0)
- Plasmodium falciparumcyclin dependent kinases (2002) (0)
- Using pyrrolo-pyrazines for the manufacture of medicaments for the treatment of cystic fibrosis and related diseases, a default addressing of proteins in cells (2004) (0)
- Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice (2019) (0)
- Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases. (2023) (0)
- Inducing supernumerary hair cells in the organ of Corti. (2002) (0)
- Intracellular Infection Functions in Parasite Viability and Drug Target and Reveals Important Leishmania donovani Casein Kinase 1 as a Pharmacological Assessment Defines (2014) (0)
- Targeting Cellular , Not Viral , Proteins Immunodeficiency Virus Type 1 by Simplex Virus and Human and Drug-Resistant Strains of Herpes Inhibitors Inhibit Replication of Wild-Type Pharmacological Cyclin-Dependent Kinase (2002) (0)
- LEVUGLANDINS AS POTENTIALLY NOVEL THERAPEUTIC APPROACHES TO ALZHEIMER’S DISEASE (2006) (0)
- Protein kinase inhibitors from the New Caledonian rainforest (2008) (0)
- New 5-ylidene rhodanine derivatives based on the dispacamide A model (2014) (0)
- The search for and potential therapeutic applications of chemical inhibitors of cyclin-dependant protein kinases (1999) (0)
- CDK1-Inhibitory Activity of Paullones Depends on Electronic Properties of 9-Substituents. (2005) (0)
- Synthesis, biological evaluation and molecular docking studies of 4-arylidene-2-phenyloxazol-5(4H)-one derivatives as inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases and Cdc2-like kinases (2021) (0)
- New derivatives including pyrazole and indole, useful as inhibitors of GSK3 kinase (2013) (0)
- Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor roscovitine (2008) (0)
- Suppression de l'activite de kinase cycline-dependante pour la prevention et le traitement des infections (2001) (0)
- New purine derivatives which possesses anti-proliferative properties and their biological applications. (1996) (0)
- Synthesis and biological evaluation of new thiazolo [5,4-f]quinazolines as serine/threonine kinases inhibitors (2015) (0)
- Abstract 3757: CR8, a novel CDK inhibitor, enhances vandetanib activity in a human medullary thyroid carcinoma model (2012) (0)
- Using paullones derivatives for the manufacture of medicaments for the treatment of mucoviscidosis and linked to a defect in targeting of proteins in cells diseases (2005) (0)
- Understanding the Molecular Underpinnings of Neuronal Kinase CDK5 mediated Metabolic Vulnerabilities in Neuroendocrine Tumors (2020) (0)
- P4-282 Effects of indirubin, a GSK3/CDK5 inhibitor, on the Aβ and tau pathways of Alzheimer’s Disease (2006) (0)
- Synthesis and evaluation of new potent inhibitors of CK1 and CDK5, two kinases involved in Alzheimer’s disease (2012) (0)
- Human DYRK2 bound to Scorzodihydrostilbene A (2019) (0)
- Strategies for the discovery of novel inhibitors of cyclin-dependent kinases (1998) (0)
- New derivatives of 9-pyrido [2,3-b] indole, their method of preparation as well as pharmaceutical compositions containing such compounds (2004) (0)
- Derivatives of imidazolone, process for the preparation and biological applications (2007) (0)
- Human DYRK1A in complex with Leucettine L41 (2012) (0)
- Using indigo similar bisindoles for preparing a medicament for inhibiting cyclin-dependent kinases (1999) (0)
- Natural and synthetic indirubins as potent and selective inhibitors of the protozoan parasite Leishmania donovani (2007) (0)
- Use of purine derivatives for making drugs for the treatment of cystic fibrosis and related diseases, a default addressing of proteins in cells (2004) (0)
- Dual Specificity, Tyrosine phosphorylation Regulated Kinases (DYRKs) in human disease: the therapeutic potential of pharmacological inhibitors (2008) (0)
- Crystal structure of human CLK1 in complex with pyrido[3,4-g]quinazoline derivative ZW31 (compound 14) (2016) (0)
- Progress in Cell Cycle Research (1997) (0)
- Characterisation of the anti-migratory activity of the 6-bromoindirubin-3’oxime (BIO) derivative VTIND42 in patient-derived GBM subpopulations (2019) (0)
- Synthesis and Biological Evaluation of Selective and Potent Cyclin‐Dependent Kinase Inhibitors. (2013) (0)
- Novel purine derivatives having in particular anti-proliferative properties and biological applications thereof (1995) (0)
- Cell cycle regulating cyclin-dependent kinases as molecular targets in screening for new anti-mitotic agents (1998) (0)
- Use of paullone derivatives for the manufacture of medicaments (2000) (0)
- Polymer-Supported Synthesis of Aigialomycin D (2006) (0)
- Use of substances modulating the expression or function of a protein involved in the cell cycle for the treatment or prevention of acute neural lesions (2000) (0)
- A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment (2020) (0)
- Synthesis of Novel 7‐Substituted Pyrido[2′,3′:4,5]furo[3,2‐d]pyrimidin‐4‐amines (VII) and Their N‐Aryl Analogues (IX) and Evaluation of Their Inhibitory Activity Against Ser/Thr Kinases. (2014) (0)
- s and reveals important functions in parasite viability and intracellular infection. t u (2013) (0)
- Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models (2019) (0)
- Using pyrrolo-pyrazine derivatives for the treatment of cystic fibrosis (2005) (0)
- The selectivity of pharmacological inhibitors of cyclin-dependent kinases [CDKS] and glycogen synthase kinase-3 [GSK-3] (2003) (0)
- Activation of the ah receptor and ah receptor signal transduction pathway by tryptophan-derived agonists (2003) (0)
- Cyclin-Dependent Kinases (1999) (0)
- Lessons learned from the optimization of natural product based kinase inhibitors through molecular calculations (2008) (0)
- New cyclin-dependant kinase inhibitors as potential anti-tumor agents (2008) (0)
- Genetic and pharmacological inhibition of Cdk1 provides neuroprotection towards ischemic neuronal death (2018) (0)
- Cyclin-Dependent Kinases and Their Chemical Inhibitors: New Targets and Tools for the Study of the Testis? (2000) (0)
- New imidazolone derivatives are dual-specificity tyrosine-phosphorylation regulated kinase 1A inhibitors useful for treating neurodegenerative diseases, preferably Alzheimer disease and other taupathy, Pick diseases or trisomy 21 (2007) (0)
- DERIVATIVES 10-Amino-1,2,3,4-tetrahydropyrido ° 2,1a isoindol-6 (10bH) - ONES, METHOD OF PREPARATION AND THERAPEUTIC USES (2009) (0)
- Using purine derivatives for the manufacture of medicaments for the treatment of cystic fibrosis and related to a defect addressing of proteins in cells diseases (2005) (0)
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What Schools Are Affiliated With Laurent Meijer?
Laurent Meijer is affiliated with the following schools:
