Lawrence Corey
American immunobiologist
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Biology
Why Is Lawrence Corey Influential?
(Suggest an Edit or Addition)According to Wikipedia, Research and career In the early 1980s, Corey worked with Nobel Prize-winning biochemist and pharmacologist Dr. Gertrude Elion to demonstrate that an antiviral that was selective and specific for a viral-specified enzyme could be safely and effectively administered to control a chronic viral infection . Corey first conceived of, demonstrated the core concepts and directed line association between quantitative viral load reduction and clinical benefit using topical, intravenous and oral formulations of acyclovir in classic studies performed between 1980 and 1984. Acyclovir was the first antiviral drug to get rapid approval from the FDA, and it was Corey's studies that defined its use in genital herpes. These studies led to the licensure for acyclovir in a wide variety of infections such as HSV-1, HSV-2 and varicella chickenpox virus, including the first use of an antiviral for daily long term use. Acyclovir and its derivatives valacyclovir and famciclovir are the most prescribed antivirals in the world: over 400 million people have HSV-2 infection. These early studies prompted the subsequent successful involvement of the pharmaceutical and medical sciences communities to develop effective antiviral therapy for HIV and Hepatitis B.
Lawrence Corey's Published Works
Published Works
- Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine (2020) (5634)
- Clinical and Epidemiologic Features of Primary HIV Infection (1996) (3365)
- Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial (2008) (1743)
- Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients. (2002) (1370)
- Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19 (2021) (1283)
- Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors. (2002) (935)
- Early establishment of a pool of latently infected, resting CD4(+) T cells during primary HIV-1 infection. (1998) (841)
- HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case–cohort analysis (2008) (750)
- Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine. AIDS Clinical Trials Group. (1996) (739)
- The acquisition of herpes simplex virus during pregnancy. (1997) (721)
- Infections with herpes simplex viruses (1). (1986) (688)
- Once-daily valacyclovir to reduce the risk of transmission of genital herpes* (2004) (612)
- Effect of serologic status and cesarean delivery on transmission rates of herpes simplex virus from mother to infant. (2003) (602)
- Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection. (1997) (586)
- Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity. (2002) (581)
- T–cell mediated rejection of gene–modified HIV–specific cytotoxic T lymphocytes in HIV–infected patients (1996) (579)
- The Effects of Herpes Simplex Virus-2 on HIV-1 Acquisition and Transmission: A Review of Two Overlapping Epidemics (2004) (572)
- Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons. (2000) (553)
- Plasma viremia in human immunodeficiency virus infection. (1989) (552)
- Vaccine prevention of maternal cytomegalovirus infection. (2009) (542)
- Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine. (2013) (536)
- Comparison of Western blot (immunoblot) and glycoprotein G-specific immunodot enzyme assay for detecting antibodies to herpes simplex virus types 1 and 2 in human sera (1988) (516)
- Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial (2021) (501)
- Emergence of ganciclovir-resistant cytomegalovirus disease among recipients of solid-organ transplants (2000) (499)
- Prolonged fluconazole prophylaxis is associated with persistent protection against candidiasis-related death in allogeneic marrow transplant recipients: long-term follow-up of a randomized, placebo-controlled trial. (2000) (494)
- Combination antifungal therapy for invasive aspergillosis. (2004) (488)
- Mucosal shedding of human herpesvirus 8 in men. (2000) (485)
- A prospective study of new infections with herpes simplex virus type 1 and type 2. Chiron HSV Vaccine Study Group. (1999) (481)
- Risk factors for the sexual transmission of genital herpes. (1992) (471)
- Modeling plasma virus concentration during primary HIV infection. (2000) (460)
- Recombinant glycoprotein vaccine for the prevention of genital HSV-2 infection: two randomized controlled trials. Chiron HSV Vaccine Study Group. (1999) (458)
- Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections. (2001) (453)
- Virologic characteristics of subclinical and symptomatic genital herpes infections. (1995) (443)
- Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial (2008) (441)
- Itraconazole versus fluconazole for prevention of fungal infections in patients receiving allogeneic stem cell transplants. (2004) (433)
- Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy (1999) (420)
- Neonatal herpes simplex virus infection in relation to asymptomatic maternal infection at the time of labor. (1991) (418)
- A strategic approach to COVID-19 vaccine R&D (2020) (411)
- Recurrences after oral and genital herpes simplex virus infection. Influence of site of infection and viral type. (1987) (405)
- Adenovirus infections in patients undergoing bone-marrow transplantation. (1985) (405)
- Genital ulceration as a risk factor for human immunodeficiency virus infection. (1988) (390)
- A population-based study of primary human herpesvirus 6 infection. (2005) (390)
- High risk of death due to bacterial and fungal infection among cytomegalovirus (CMV)-seronegative recipients of stem cell transplants from seropositive donors: evidence for indirect effects of primary CMV infection. (2002) (384)
- Predictors of morbidity and mortality in neonates with herpes simplex virus infections (1991) (370)
- Persistence of HIV-1 Receptor-Positive Cells after HSV-2 Reactivation: A Potential Mechanism for Increased HIV-1 Acquisition (2009) (368)
- Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment. (1997) (366)
- In vivo migration and function of transferred HIV-1-specific cytotoxic T cells (1999) (361)
- Influenza infections after hematopoietic stem cell transplantation: risk factors, mortality, and the effect of antiviral therapy. (2004) (358)
- Improved outcome in central nervous system aspergillosis, using voriconazole treatment. (2005) (351)
- Safety of and immunological response to a recombinant vaccinia virus vaccine expressing HIV envelope glycoprotein (1991) (335)
- Frequent recovery of HIV-1 from genital herpes simplex virus lesions in HIV-1-infected men. (1998) (331)
- Evidence for Human Immunodeficiency Virus Type 1 Replication In Vivo in CD14+ Monocytes and Its Potential Role as a Source of Virus in Patients on Highly Active Antiretroviral Therapy (2002) (325)
- Effect of condoms on reducing the transmission of herpes simplex virus type 2 from men to women. (2001) (320)
- Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation (2007) (319)
- Biological and Virologic Characteristics of Primary HIV Infection (1998) (317)
- Comparison of Real-Time PCR Assays with Fluorescent-Antibody Assays for Diagnosis of Respiratory Virus Infections in Children (2006) (315)
- Valganciclovir reduces T cell activation in HIV-infected individuals with incomplete CD4+ T cell recovery on antiretroviral therapy. (2011) (314)
- A double-blind study of oral acyclovir for suppression of recurrences of genital herpes simplex virus infection. (1984) (313)
- Association between culturable human immunodeficiency virus type 1 (HIV-1) in semen and HIV-1 RNA levels in semen and blood: evidence for compartmentalization of HIV-1 between semen and blood. (1998) (313)
- Safety and efficacy of the HVTN 503/Phambili study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study. (2011) (310)
- Phase 3 Safety and Efficacy of AZD1222 (ChAdOx1 nCoV-19) Covid-19 Vaccine (2021) (308)
- Herpes simplex virus pneumonia: clinical, virologic, and pathologic features in 20 patients. (1982) (304)
- The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia. (1997) (303)
- Human herpesvirus 6 in lung tissue from patients with pneumonitis after bone marrow transplantation. (1993) (302)
- Risk of recurrence after first episodes of genital herpes. Relation to HSV type and antibody response. (1981) (300)
- Polymerase chain reaction for detection of herpes simplex virus (HSV) DNA on mucosal surfaces: comparison with HSV isolation in cell culture. (2003) (295)
- Clinical outcomes of human herpesvirus 6 reactivation after hematopoietic stem cell transplantation. (2005) (294)
- Genital HIV-1 RNA Predicts Risk of Heterosexual HIV-1 Transmission (2011) (294)
- Changing presentation of herpes simplex virus infection in neonates. (1988) (290)
- Clearance of HSV-2 from recurrent genital lesions correlates with infiltration of HSV-specific cytotoxic T lymphocytes. (1998) (279)
- Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase (2021) (278)
- Parainfluenza virus infections after hematopoietic stem cell transplantation: risk factors, response to antiviral therapy, and effect on transplant outcome. (2001) (271)
- Infections with herpes simplex viruses. (Second of two parts) (1986) (270)
- Optimization of Quantitative Detection of Cytomegalovirus DNA in Plasma by Real-Time PCR (2004) (267)
- A controlled trial comparing vidarabine with acyclovir in neonatal herpes simplex virus infection. Infectious Diseases Collaborative Antiviral Study Group. (1991) (258)
- Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2. (2010) (257)
- Frequent detection of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in saliva of human immunodeficiency virus-infected men: clinical and immunologic correlates. (1997) (257)
- Recent Progress in Herpes Simplex Virus Immunobiology and Vaccine Research (2003) (255)
- Suppression of Subclinical Shedding of Herpes Simplex Virus Type 2 with Acyclovir (1996) (255)
- Antibody to herpes simplex virus type 2 as serological marker of sexual lifestyle in populations (1994) (255)
- Genital herpes and public health: addressing a global problem. (2000) (255)
- Therapy of herpes zoster with oral acyclovir. (1988) (254)
- Genital Herpes Has Played a More Important Role than Any Other Sexually Transmitted Infection in Driving HIV Prevalence in Africa (2008) (254)
- A trial of topical acyclovir in genital herpes simplex virus infections. (1982) (252)
- Effects on infants of a first episode of genital herpes during pregnancy. (1987) (248)
- Herpes Simplex Virus Inhibits Apoptosis through the Action of Two Genes, Us5 and Us3 (1999) (243)
- Incidence and outcome of cytomegalovirus infections following nonmyeloablative compared with myeloablative allogeneic stem cell transplantation, a matched control study. (2002) (242)
- Frequency of symptomatic and asymptomatic herpes simplex virus type 2 reactivations among human immunodeficiency virus-infected men. (1998) (242)
- Isolation of human immunodeficiency virus from genital ulcers in Nairobi prostitutes. (1989) (241)
- Clade B-based HIV-1 vaccines elicit cross-clade cytotoxic T lymphocyte reactivities in uninfected volunteers. (1997) (239)
- Diseases that mimic herpes simplex encephalitis. Diagnosis, presentation, and outcome. NIAD Collaborative Antiviral Study Group. (1989) (237)
- Frequency of Acquisition of First‐episode Genital Infection with Herpes Simplex Virus from Symptomatic and Asymptomatic Source Contacts (1985) (237)
- Immune reconstitution to cytomegalovirus after allogeneic hematopoietic stem cell transplantation: impact of host factors, drug therapy, and subclinical reactivation. (2003) (237)
- Assessment of hepatitis C virus RNA levels by quantitative competitive RNA polymerase chain reaction: high-titer viremia correlates with advanced stage of disease. (1994) (233)
- Brief Communication: Fatal Human Metapneumovirus Infection in Stem-Cell Transplant Recipients (2006) (229)
- Genetic impact of vaccination on breakthrough HIV-1 sequences from the Step trial (2011) (229)
- Immune Surveillance by CD8αα+ Skin Resident T Cells in Human Herpesvirus Infection (2013) (228)
- Herpes simplex: insights on pathogenesis and possible vaccines. (2008) (218)
- Development of a High-Throughput Quantitative Assay for Detecting Herpes Simplex Virus DNA in Clinical Samples (1999) (215)
- Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection. (2011) (214)
- Remission of HHV-8 and HIV-associated multicentric Castleman disease with ganciclovir treatment. (2004) (213)
- Placebo-controlled trial of vaccination with recombinant glycoprotein D of herpes simplex virus type 2 for immunotherapy of genital herpes (1994) (212)
- Rising pp65 antigenemia during preemptive anticytomegalovirus therapy after allogeneic hematopoietic stem cell transplantation: risk factors, correlation with DNA load, and outcomes. (2001) (210)
- Transfusion-transmitted cytomegalovirus infection after receipt of leukoreduced blood products. (2003) (210)
- Antibody to human immunodeficiency virus (HIV) and suboptimal response to hepatitis B vaccination. (1988) (208)
- CHANGES IN PLASMA HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 RNA ASSOCIATED WITH HERPES SIMPLEX VIRUS REACTIVATION AND SUPPRESSION (2002) (207)
- Respiratory virus infection among hematopoietic cell transplant recipients: evidence for asymptomatic parainfluenza virus infection. (2007) (202)
- Cytomegalovirus reactivation in critically ill immunocompetent patients. (2008) (202)
- Immune responses to human immunodeficiency virus (HIV) type 1 induced by canarypox expressing HIV-1MN gp120, HIV-1SF2 recombinant gp120, or both vaccines in seronegative adults. NIAID AIDS Vaccine Evaluation Group. (1998) (201)
- Extended follow-up confirms early vaccine-enhanced risk of HIV acquisition and demonstrates waning effect over time among participants in a randomized trial of recombinant adenovirus HIV vaccine (Step Study). (2012) (200)
- Persistent hepatitis C virus infection after liver transplantation: Clinical and virological features (1995) (200)
- Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: implications for eradication of virus. (2007) (199)
- Transmissible Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in saliva of men with a history of Kaposi's sarcoma (1997) (199)
- Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults. (2008) (198)
- After the pandemic: perspectives on the future trajectory of COVID-19 (2021) (197)
- Maternal and neonatal herpes simplex virus infections. (2009) (197)
- Application of the Polymerase Chain Reaction to the Diagnosis and Management of Neonatal Herpes Simplex Virus Disease (1996) (195)
- Enhanced immunity to human immunodeficiency virus (HIV) envelope elicited by a combined vaccine regimen consisting of priming with a vaccinia recombinant expressing HIV envelope and boosting with gp160 protein. (1993) (195)
- Quantitation of BK virus load in serum for the diagnosis of BK virus-associated nephropathy in renal transplant recipients. (2001) (193)
- A framework for assessing immunological correlates of protection in vaccine trials. (2007) (192)
- Activation of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Lytic Replication by Human Cytomegalovirus (2001) (191)
- Intravenous acyclovir for the treatment of primary genital herpes. (1983) (191)
- Effect of antivirals on human herpesvirus 6 replication in hematopoietic stem cell transplant recipients. (2002) (190)
- Estimating the Impact of Plasma HIV-1 RNA Reductions on Heterosexual HIV-1 Transmission Risk (2010) (189)
- Herpes simplex virus (HSV) suppression with valacyclovir reduces rectal and blood plasma HIV-1 levels in HIV-1/HSV-2-seropositive men: a randomized, double-blind, placebo-controlled crossover trial. (2007) (188)
- Development of clinically recognizable genital lesions among women previously identified as having "asymptomatic" herpes simplex virus type 2 infection. (1989) (187)
- SARS-CoV-2 Variants in Patients with Immunosuppression. (2021) (186)
- Innate immunity in human immunodeficiency virus infection: effect of viremia on natural killer cell function. (2003) (184)
- Underdiagnosis of Genital Herpes by Current Clinical and Viral-Isolation Procedures (1992) (182)
- Chronic fatigue. A prospective clinical and virologic study. (1990) (180)
- Diversion of HIV-1 vaccine–induced immunity by gp41-microbiota cross-reactive antibodies (2015) (179)
- Valaciclovir for the suppression of recurrent genital herpes simplex virus infection: a large-scale dose range-finding study. International Valaciclovir HSV Study Group. (1998) (179)
- Phase 1 evaluation of the respiratory syncytial virus-specific monoclonal antibody palivizumab in recipients of hematopoietic stem cell transplants. (2001) (176)
- Immune correlates of vaccine protection against HIV-1 acquisition (2015) (175)
- Treatment of Recurrent Genital Herpes Simplex Infections With Oral Acyclovir: A Controlled Trial (1984) (174)
- Infection of Macaca nemestrina by human immunodeficiency virus type-1. (1992) (174)
- Cyclophosphamide metabolism is affected by azole antifungals. (2004) (173)
- Prospects for a safe COVID-19 vaccine (2020) (173)
- DIFFERENCE BETWEEN HERPES SIMPLEX VIRUS TYPE I AND TYPE 2 NEONATAL ENCEPHALITIS IN NEUROLOGICAL OUTCOME (1988) (172)
- Effect of combination antiretroviral therapy on T-cell immunity in acute human immunodeficiency virus type 1 infection. (2000) (172)
- Dual HIV-1 infection associated with rapid disease progression (2004) (172)
- Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon-Secreting CD8+ T Cells in Primary HIV-1 Infection (2003) (171)
- Treatment of Refractory BK Virus‐Associated Nephropathy With Cidofovir (2003) (170)
- One-year acyclovir prophylaxis for preventing varicella-zoster virus disease after hematopoietic cell transplantation: no evidence of rebound varicella-zoster virus disease after drug discontinuation. (2007) (170)
- Comparison of viral isolation, direct immunofluorescence, and indirect immunoperoxidase techniques for detection of genital herpes simplex virus infection (1981) (169)
- Immunotherapy of recurrent genital herpes with recombinant herpes simplex virus type 2 glycoproteins D and B: results of a placebo-controlled vaccine trial. (1997) (168)
- High‐Throughput Quantitative Analysis of Hepatitis B Virus DNA in Serum Using the TaqMan Fluorogenic Detection System (2000) (168)
- Famciclovir for the Suppression of Symptomatic and Asymptomatic Herpes Simplex Virus Reactivation in HIV-Infected Persons: A Double-Blind, Placebo-Controlled Trial (1998) (168)
- Enhanced: The Need for a Global HIV Vaccine Enterprise (2003) (168)
- Successful modification of a pp65 antigenemia-based early treatment strategy for prevention of cytomegalovirus disease in allogeneic marrow transplant recipients. (1999) (167)
- Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects. (1999) (166)
- A Recombinant Glycoprotein Vaccine for Herpes Simplex Type 2: Safety and Efficacy (1995) (163)
- BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients. (2005) (161)
- Assessment of Hepatitis C Viremia Using Molecular Amplification Technologies: Correlations and Clinical Implications (1995) (159)
- Adenovirus infection in hematopoietic stem cell transplantation: effect of ganciclovir and impact on survival. (2003) (159)
- Tracking hepatitis C virus quasispecies major and minor variants in symptomatic and asymptomatic liver transplant recipients (1996) (159)
- A humanized non-FcR-binding anti-CD3 antibody, visilizumab, for treatment of steroid-refractory acute graft-versus-host disease. (2002) (158)
- Cytomegalovirus infection in sex partners: evidence for sexual transmission. (1985) (158)
- Increased incidence of cytomegalovirus disease after autologous CD34-selected peripheral blood stem cell transplantation. (1999) (157)
- Direct recovery of herpes simplex virus (HSV)-specific T lymphocyte clones from recurrent genital HSV-2 lesions. (1994) (157)
- Persistence in the population: epidemiology, transmission (2007) (156)
- Rapid accumulation of human immunodeficiency virus (HIV) in lymphatic tissue reservoirs during acute and early HIV infection: implications for timing of antiretroviral therapy. (2000) (154)
- A double-blind, randomized, placebo-controlled trial of acyclovir in late pregnancy for the reduction of herpes simplex virus shedding and cesarean delivery. (2003) (154)
- Human herpesvirus 6 DNA in peripheral blood cells and saliva from immunocompetent individuals (1993) (154)
- The Frequency of Unrecognized Type 2 Herpes Simplex Virus Infection Among Women Implications for the Control of Genital Herpes (1990) (153)
- Valacyclovir and acyclovir for suppression of shedding of herpes simplex virus in the genital tract. (2004) (153)
- Immunization with recombinant canarypox vectors expressing membrane-anchored glycoprotein 120 followed by glycoprotein 160 boosting fails to generate antibodies that neutralize R5 primary isolates of human immunodeficiency virus type 1. (2000) (153)
- Safety and immunogenicity of a canarypox-vectored human immunodeficiency virus Type 1 vaccine with or without gp120: a phase 2 study in higher- and lower-risk volunteers. (2001) (153)
- Evolution of Hepatitis C Virus Quasispecies in Hypervariable Region 1 and the Putative Interferon Sensitivity-Determining Region during Interferon Therapy and Natural Infection (1998) (152)
- Severe genital herpes infections in HIV-infected individuals with impaired herpes simplex virus-specific CD8+ cytotoxic T lymphocyte responses. (1997) (152)
- Association between cervical shedding of herpes simplex virus and HIV-1 (2002) (152)
- Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipients. (2010) (151)
- Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico (2021) (151)
- Airflow Decline after Myeloablative Allogeneic Hematopoietic Cell Transplantation: The Role of Community Respiratory Viruses (2006) (151)
- Functional Analysis of the Human Cytomegalovirus US28 Gene by Insertion Mutagenesis with the Green Fluorescent Protein Gene (1998) (150)
- Chlamydia pneumoniae, Herpes Simplex Virus Type 1, and Cytomegalovirus and Incident Myocardial Infarction and Coronary Heart Disease Death in Older Adults: The Cardiovascular Health Study (2000) (149)
- Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition. (2021) (148)
- A Phase IIA Randomized Clinical Trial of a Multiclade HIV-1 DNA Prime Followed by a Multiclade rAd5 HIV-1 Vaccine Boost in Healthy Adults (HVTN204) (2011) (148)
- Natural History of Genital Herpes Simplex Virus Type 1 Infection (2003) (147)
- Divergent patterns of progression to AIDS after infection from the same source: human immunodeficiency virus type 1 evolution and antiviral responses (1997) (146)
- CD27 Expression Promotes Long-Term Survival of Functional Effector–Memory CD8+Cytotoxic T Lymphocytes in HIV-infected Patients (2004) (146)
- Human herpesvirus 6 infections after bone marrow transplantation: clinical and virologic manifestations. (1999) (145)
- Inability of enzyme immunoassays to discriminate between infections with herpes simplex virus types 1 and 2. (1991) (145)
- Evolutionary pattern of human immunodeficiency virus (HIV) replication and distribution in lymph nodes following primary infection: Implications for antiviral therapy (1998) (145)
- Immune Correlates Analysis of the mRNA-1273 COVID-19 Vaccine Efficacy Trial (2021) (144)
- Valganciclovir for suppression of human herpesvirus-8 replication: a randomized, double-blind, placebo-controlled, crossover trial. (2008) (143)
- Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific for a skin-tropic virus. (2002) (143)
- Quantitative Stability of DNA after Extended Storage of Clinical Specimens as Determined by Real-Time PCR (2002) (142)
- A randomized, double-blind, placebo-controlled trial of cidofovir gel for the treatment of acyclovir-unresponsive mucocutaneous herpes simplex virus infection in patients with AIDS. (1997) (142)
- Efficacy of a viral load-based, risk-adapted, preemptive treatment strategy for prevention of cytomegalovirus disease after hematopoietic cell transplantation. (2012) (142)
- QS-21 promotes an adjuvant effect allowing for reduced antigen dose during HIV-1 envelope subunit immunization in humans. (2001) (141)
- The Relationship between Condom Use and Herpes Simplex Virus Acquisition (2005) (141)
- Productive infection of T cells in lymphoid tissues during primary and early human immunodeficiency virus infection. (2001) (140)
- Long-term entecavir treatment results in sustained antiviral efficacy and prolonged life span in the woodchuck model of chronic hepatitis infection. (2001) (140)
- Antigenic specificities of human CD4+ T-cell clones recovered from recurrent genital herpes simplex virus type 2 lesions (1994) (140)
- Recovery of human immunodeficiency virus type 1 from semen: minimal impact of stage of infection and current antiviral chemotherapy. (1991) (139)
- The management of pregnancies complicated by genital infections with herpes simplex virus. (1992) (139)
- Daily aciclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trial (2010) (138)
- Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection (2006) (136)
- Combination Therapy with Zidovudine and Didanosine Compared with Zidovudine Alone in HIV-1 Infection (1993) (134)
- Invasive aspergillosis before allogeneic hematopoietic stem cell transplantation: 10-year experience at a single transplant center. (2004) (133)
- Asymptomatic reactivation of herpes simplex virus in women after the first episode of genital herpes. (1992) (133)
- Early and persistent human immunodeficiency virus type 1 (HIV-1)-specific T helper dysfunction in blood and lymph nodes following acute HIV-1 infection. (1999) (133)
- Vaccination of vaccinia-naive adults with human immunodeficiency virus type 1 gp160 recombinant vaccinia virus in a blinded, controlled, randomized clinical trial. The AIDS Vaccine Clinical Trials Network. (1992) (133)
- Analysis of genetic polymorphisms in CCR5, CCR2, stromal cell-derived factor-1, RANTES, and dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in seronegative individuals repeatedly exposed to HIV-1. (2004) (133)
- The current trend in genital herpes. Progress in prevention. (1994) (133)
- Differences in clinical outcomes after 2009 influenza A/H1N1 and seasonal influenza among hematopoietic cell transplant recipients. (2011) (132)
- Rhinovirus Infections in Hematopoietic Stem Cell Transplant Recipients with Pneumonia (2003) (132)
- HSV and Glycoprotein J Inhibit Caspase Activation and Apoptosis Induced by Granzyme B or Fas1 (2001) (130)
- CD8 CTL from Genital Herpes Simplex Lesions: Recognition of Viral Tegument and Immediate Early Proteins and Lysis of Infected Cutaneous Cells1 (2001) (128)
- Extended duration of herpes simplex virus DNA in genital lesions detected by the polymerase chain reaction. (1991) (127)
- Use of aminotransferase, hepatitis C antibody, and hepatitis C polymerase chain reaction RNA assays to establish the diagnosis of hepatitis C virus infection in a diagnostic virology laboratory (1992) (126)
- Current Concepts for Genital Herpes Simplex Virus Infection: Diagnostics and Pathogenesis of Genital Tract Shedding (2015) (125)
- Herpes simplex virus (HSV)-suppressive therapy decreases plasma and genital HIV-1 levels in HSV-2/HIV-1 coinfected women: a randomized, placebo-controlled, cross-over trial. (2008) (124)
- Detection of Epstein-Barr Virus DNA in Sera from Transplant Recipients with Lymphoproliferative Disorders (1999) (123)
- Treatment of primary human immunodeficiency virus type 1 infection with potent antiretroviral therapy reduces frequency of rapid progression to AIDS. (2001) (123)
- Role for HLA class II molecules in HIV-1 suppression and cellular immunity following antiretroviral treatment. (2001) (122)
- The efficacy of antimalarial monotherapies, sulphadoxine–pyrimethamine and amodiaquine in East Africa: implications for sub‐regional policy (2003) (120)
- USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus: disease-specific recommendations. USPHS/IDSA Prevention of Opportunistic Infections Working Group. (1995) (120)
- Monoclonal antibodies to herpes simplex viruses: use in antigenic typing and rapid diagnosis. (1983) (120)
- Herpes Simplex Virus Type 1 Renders Infected Cells Resistant to Cytotoxic T-Lymphocyte-Induced Apoptosis (1998) (119)
- Human CD8+ herpes simplex virus-specific cytotoxic T-lymphocyte clones recognize diverse virion protein antigens (1992) (119)
- HHV-6 reactivation and its effect on delirium and cognitive functioning in hematopoietic cell transplantation recipients. (2011) (118)
- Frequent detection of genital herpes simplex virus DNA by polymerase chain reaction among pregnant women (1994) (118)
- Diagnosis of herpes simplex virus by direct immunofluorescence and viral isolation from samples of external genital lesions in a high-prevalence population (1987) (117)
- Frequent reactivation of herpes simplex virus among HIV-1-infected patients treated with highly active antiretroviral therapy. (2004) (117)
- BK virus infection in hematopoietic stem cell transplant recipients: frequency, risk factors, and association with postengraftment hemorrhagic cystitis. (2004) (115)
- Phase 2 Study of an HIV-1 Canarypox Vaccine (vCP1452) Alone and in Combination With rgp120: Negative Results Fail to Trigger a Phase 3 Correlates Trial (2007) (115)
- Virological, clinical, and ophthalmologic features of cytomegalovirus retinitis after hematopoietic stem cell transplantation. (2001) (115)
- Clinical efficacy of high-dose acyclovir in patients with human immunodeficiency virus infection: a meta-analysis of randomized individual patient data. (1998) (115)
- Diminished Interferon-γ and Lymphocyte Proliferation in Neonatal and Postpartum Primary Herpes Simplex Virus Infection (1992) (114)
- Helicase-primase inhibitor pritelivir for HSV-2 infection. (2014) (114)
- Double-blind, placebo-controlled trial of a herpes simplex virus type 2 glycoprotein vaccine in persons at high risk for genital herpes infection. (1990) (114)
- Cervical shedding of herpes simplex virus in human immunodeficiency virus-infected women: effects of hormonal contraception, pregnancy, and vitamin A deficiency. (2000) (113)
- HHV-6 reactivation and associated sequelae after hematopoietic cell transplantation. (2012) (112)
- Pharmacokinetics of acyclovir in the term human pregnancy and neonate. (1991) (112)
- Synergistic copathogens--HIV-1 and HSV-2. (2007) (112)
- A Randomized, Placebo-Controlled Comparison of Oral Valacyclovir and Acyclovir in Immunocompetent Patients With Recurrent Genital Herpes Infections (1998) (112)
- Pharmacokinetic disposition of zidovudine during pregnancy. (1991) (112)
- Recurrent genital herpes simplex virus infection in pregnancy: infant outcome and frequency of asymptomatic recurrences. (1982) (111)
- Comparison of conventional and molecular detection of respiratory viruses in hematopoietic cell transplant recipients (2009) (111)
- Human herpesvirus 6 reactivation and encephalitis in allogeneic bone marrow transplant recipients. (2001) (111)
- HIV vaccines: new frontiers in vaccine development. (2006) (110)
- Two-day regimen of acyclovir for treatment of recurrent genital herpes simplex virus type 2 infection. (2002) (110)
- Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes (2010) (110)
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- A double-blind study of oral acyclovir for suppression of recurrences of genital herpes simplex virus infection (1984) (0)
- Recurring Genital Herpes CTL in Persons with + Virus-Specific CD 8 Long Term Persistence of Herpes Simplex (2000) (0)
- CMV Infection and Disease after Nonmyeloablative (NM) HCT Revisited: Incidence, Risk Factors, Ganciclovir-Related Neutropenia and Outcome. (2005) (0)
- Tissue resident memory CD8 T cells augment innate immunity for tissue-wide antiviral protection (2016) (0)
- Response : The role of antiviral agents in the treatment of multicentric Castleman disease (2004) (0)
- Author response: Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract (2012) (0)
- Concepts in the Development of Vaccines Against Genital Herpes Simplex Virus Infections (1985) (0)
- T Cells + CD4Lymphoblastoid B Cell Lines to Stimulate Herpes Simplex Inhibits the Capacity of (2001) (0)
- Author response: Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract (2012) (0)
- Antiviral chemotherapy 4 : new directions for clincal application and rersearch (2017) (0)
- HHV‐8: Anatomic Sites, Shedding Patterns, Behavioral and Biological Risk Factors for Transmission.: ABSTRACT S10 (2000) (0)
- Adoptive Immunotherapy of Human Diseases with Antigen-Specific T-Cell Clones (2000) (0)
- DELAYED PRODUCTION OF INTERFERON-GAMMA (IFNγ) AND TUMOR NECROSIS FACTOR (TNFα) BY MONONUCLEAR CELLS (MC) OF HERPES SIMPLEX VIRUS (HSV) INFECTED NEONATES (NB) (1987) (0)
- Plasma and CSF herpes simplex virus levels at diagnosis and outcome of neonatal infection (2015) (0)
- P11-17. Intermittent rectal shedding of multiple human adenovirus serotypes among HIV-positive MSM (2009) (0)
- voriconazole treatment Improved outcome in central nervous system aspergillosis, using (2013) (0)
- Annals of Internal Medicine (1996) (0)
- Preliminary safety and activity evaluation of new agents for the treatment of HIV-1 infection: Recommended guidelines for trial design (1992) (0)
- Clinical perspectives in the treatment of HIV disease: the role of didanosine. Introduction. (1993) (0)
- Virus and host-specific differences in oral human herpesvirus shedding kinetics among Ugandan women and children (2017) (0)
- Is viral shedding a surrogate marker for transmission of genital herpes? Introduction (2004) (0)
- InfectionControl of Chronic Human Herpesvirus 8 T Cells Involvement in Viral Immune + (2008) (0)
- SARS-CoV-2 neutralizing-antibody responses in convalescent individuals in US and Peru (2021) (0)
- HumanHerpesvirus 6DNA inPeripheral BloodCells and Saliva fromImmunocompetent Individuals (1993) (0)
- P3-S2.03 Clinical evaluation of the BD HSV1 Qx assay for the direct qualitative testing of HSV1 as compared to viral culture and a laboratory-based PCR assay using male and female external anogenital lesions (2011) (0)
- Contributors (2015) (0)
- Impact of neutralizing antibody to respiratory syncytial virus (RSV) on respiratory disease progression in hematopoietic stem cell transplant recipients (HCT) (2006) (0)
- A Large Cohort Analysis of CMV Viral Load and Ganciclovir-Related Neutropenia in Nonmyeloablative (NM-HCT) and Myeloablative (M-HCT) Allogeneic Hematopoietic Cell Transplant Recipients. (2007) (0)
- Baeten Genital HIV-1 RNA Predicts Risk of Heterosexual HIV-1 Transmission (2011) (0)
- Enterovirus RNA in Cerebrospinal Fluid Liquid-Phase Hybridization for Detection of Evaluation of Real-Time PCR versus PCR with (2003) (0)
- rebound VZV disease after drug discontinuation disease following hematopoietic cell transplantation: no evidence of One-year acyclovir prophylaxis for preventing varicella-zoster virus (VZV) (2013) (0)
- 80: Primary CMV Infection in CMV Seronegative Recipients of a Stem Cell Product from a Seropositive Donor (D+/R-): Frequency of and Risk Factors for Transmission (2008) (0)
- In Vivo Inhibition of Type I Interferon Transcription in Genital HSV-2 Lesions (134.72) (2009) (0)
- Safety and Immunogenicity of Ad26-vectored HIV Vaccine with Mosaic Immunogens and a Novel Mosaic Envelope Protein in HIV-uninfected Adults: A Phase 1/2a Study. (2022) (0)
- Antibody toherpes simplex virus type2asserological markerof sexual lifestyle inpopulations (1994) (0)
- 53 Long-term suppressive acyclovir (ACV) use reduces Varicella zoster (VZV) diseases and emergence of ACV-resistant herpes simplex viruses (HSV) after stem cell transplantation (HCT) (2006) (0)
- reprogramming of the primary immune response by T cell receptor antagonism (2004) (0)
- C6/36 cells are unable to produce a Dicer-2-like product. (2013) (0)
- Effect of aciclovir on HIV-1 acquisition in HSV-2-positive patients – Authors' reply (2008) (0)
- In Memoriam: Stephen Sacks (2004) (0)
- Topical Treatment ofInfection withAcyclovir-Resist ant Mucocutaneous HerpesSimplex Viruswith theRibonucleotide Reductase Inhibitor 348U87 inCombination withAcyclovir (1993) (0)
- Evaluation of a Novel Viral Load Based Surveillance Strategy for Prevention of Cytomegalovirus (CMV) Disease in Hematopoietic Cell Transplantation (2011) (0)
- Poor immunogenicity as the reason for the ineffectiveness of a glycoprotein subunit vaccine for genital herpes (1989) (0)
- A CAR RNA FISH assay to study functional and spatial heterogeneity of chimeric antigen receptor T cells in tissue (2021) (0)
- P3-S2.04 Clinical evaluation of the BD HSV2 Qx assay for the direct qualitative testing of HSV2 as compared to viral culture and a laboratory-based PCR assay using male and female external anogenital lesions (2011) (0)
- HLA A*01 and B*08 are associated with increased genital shredding of HSV-2 (2009) (0)
- Incidence of Neonatal Herpes Simplex Infections-Reply (1985) (0)
- The Herpesviruses (1985) (0)
- INFECTIOUS DISEASES: Genital Herpes Recurrence Rates (1999) (0)
- Calibration of Two Validated SARS-CoV-2 Pseudovirus Neutralization Assays for COVID-19 Vaccine Evaluation (2021) (0)
- A meta-analysis of passive immunization studies shows an association of serum neutralizing antibody titer with protection against SHIV challenge (2019) (0)
- Kinetics of the Antibody Response to Symptomatic SARS-CoV-2 Infection in Vaccinated and Unvaccinated Individuals in the Blinded Phase of the mRNA-1273 COVID-19 Vaccine Efficacy Trial. (2023) (0)
- Immune correlates analysis of a phase 3 trial of the AZD1222 (ChAdOx1 nCoV-19) vaccine (2023) (0)
- Antigenic Specificities ofHumanCD4+T-Cell Clones Recovered fromRecurrent Genital HerpesSimplex Virus Type2Lesions (1994) (0)
- HIV-1 Vaccine Sequences Impact V1V2 Antibody Responses: A Comparison of Two Poxvirus Prime gp120 Boost Vaccine Regimens (2020) (0)
- HSV-2 and HIV (1997) (0)
- COVID-19 vaccination and HIV-1 acquisition – Authors’ reply (2022) (0)
- Lower SARS-CoV-2-Specific Humoral Immunity in People Living With HIV-1 Recovered From Symptomatic Non-Hospitalized COVID-19 (2022) (0)
- Human Herpesvirus 6B and Pulmonary Disease after Hematopoietic Cell Transplantation (2019) (0)
- Using Haplotype-Based Artificial Intelligence to Evaluate SARS-CoV-2 Novel Variants and Mutations (2023) (0)
- Pharmacokinetic Serum Concentrations of VRC01 Correlate with Prevention of HIV-1 Acquisition (2022) (0)
- Membrane-associated antigens of herpes simplex virus. Discussion (1991) (0)
- Detection of Kaposis sarcoma associated herpesvirus in saliva of human immunodeficiency virus infected individuals with and without Kaposis sarcoma (1996) (0)
- Cesarean Delivery in Women With Genital Herpes (1997) (0)
- HIV vaccine effectiveness and the mucosal interface (2007) (0)
- What constitutes successful therapeutic strategies for genital herpes (2000) (0)
- subclinical reactivation stem cell transplantation: impact of host factors, drug therapy, and Immune reconstitution to cytomegalovirus after allogeneic hematopoietic (2013) (0)
- Molecular weight variability in the terminal and joint fragments of bam h i digests of herpes simplex virus type 2 dna is eliminated by double digestion with bam h i and pvu i i (1987) (0)
- Characteristics of Primary HIV Infection (1999) (0)
- Effect of Pritelivir ComparedWith Valacyclovir on Genital HSV-2 Shedding in PatientsWith Frequent Recurrences (2017) (0)
- Interferon-Gamma for Human Papillomavirus Infection (2020) (0)
- Lawrence Corey Immunobiology and Vaccine Research Recent Progress in Herpes Simplex Virus (2002) (0)
- P17-25. A model for coverage of T-cell HIV vaccines: where are we and where do we need to be? (2009) (0)
- General Obstetrics and Gynecology-Gynecology-Cervical shedding of herpes simplex virus and cytomegalovirus throughout the menstrual cycle in women infected with human immunodeficiency virus type (2000) (0)
- Author Correction: A CAR RNA FISH assay to study functional and spatial heterogeneity of chimeric antigen receptor T cells in tissue (2021) (0)
- Topical Idoxuridine in the Treatment of Genital Herpes-Reply (1983) (0)
- Genital Herpes and Erythema Multiforme-Reply (1983) (0)
- HLA targeting efficiency correlates with human T-cell responses magnitude and with mortality from Influenza-A infection (105.30) (2012) (0)
- Lack of detection of HSV DNA in PBMCs and lymph nodes of HIV-infected persons. (1996) (0)
- N t-lymphocytes and thus identified hsv-antigenic (2003) (0)
- Reduced T-cell Infiltration at Site of Herpes Simplex Virus (HSV) Reactivation in Controlled HIV (2016) (0)
- CD277 reduces B cell Activation by HIV Env Immunogens (2016) (0)
- CLINICAL AND LABORATORY OBSERVATIONS (1983) (0)
- Development of flow cytometry‐based assays to assess the ability of antibodies to bind to SARS‐CoV‐2‐infected and spike‐transfected cells and mediate NK cell degranulation (2022) (0)
- 282 HERPES SIMPLEX VIRUS-INFECTED CELLS INACTIVATE CYTOTOXIC T LYMPHOCYTES: INSIGHT INTO A NOVEL IMMUNE EVASION MECHANISM. (2004) (0)
- Comparison ofNeutralization andDNA Restriction Enzyme MethodsforTyping Clinical Isolates ofHuman Adenovirus (1985) (0)
- In reply [6] (2006) (0)
- Granzyme B or Fas Activation and Apoptosis Induced by HSV and Glycoprotein J Inhibit Caspase (2001) (0)
- Factors affecting the transmission rates of genital herpes: considerations for designing vaccine field trials (1989) (0)
- AIDS and HIV infection. (1990) (0)
- Recent Advances in the Diagnosis of Hepatitis (1980) (0)
- Improved outcome in CNS aspergillosis, using voriconazole [5] (2006) (0)
- Detection of Adeno-Associated Virus (AAV) Viremia in Hematopoietic Cell Transplant (HCT) Recipients (2007) (0)
- Development of anti-PD-1 chimeric antigen receptor T cells to target a PD-1+ CD4 T cell population enriched in HIV provirus (2019) (0)
- Durability of Protection Against Symptomatic COVID-19 Among Participants of the mRNA-1273 SARS-CoV-2 Vaccine Trial (2022) (0)
- O3-S5.01 Impact of AIC316, a novel antiviral helicase-primase inhibitor, on genital HSV shedding: randomised, double-blind, placebo-controlled trial (2011) (0)
- CHARACTERISTICS OF PRIMARY HIV INFECTION. AUTHORS' REPLY (1999) (0)
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