Leah E. Cowen
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Canadian mycologist
Leah E. Cowen's AcademicInfluence.com Rankings
Leah E. Cowenbiology Degrees
Biology
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Microbiology
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Biology
Leah E. Cowen's Degrees
- PhD Microbiology University of California, San Francisco
- Bachelors Microbiology University of British Columbia
Why Is Leah E. Cowen Influential?
(Suggest an Edit or Addition)According to Wikipedia, Leah Elizabeth Cowen is a Canadian mycologist and the Vice-President, Research and Innovation, and Strategic Initiatives at the University of Toronto. Early life and education Cowen earned her Bachelor of Science degree from the University of British Columbia and her PhD from the University of Toronto . During this time, she received a postgraduate scholarship from the Natural Sciences and Engineering Research Council and completed her postdoctoral fellowship at the Whitehead Institute. While at MIT, she also received the 2005 Genzyme Postdoctoral Fellowship.
Leah E. Cowen's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Hsp90 Potentiates the Rapid Evolution of New Traits: Drug Resistance in Diverse Fungi (2005) (612)
- Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease (2011) (481)
- Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease (2009) (356)
- Mechanisms of Antifungal Drug Resistance. (2015) (350)
- The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype (2008) (307)
- Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin (2009) (296)
- Hsp90 Orchestrates Temperature-Dependent Candida albicans Morphogenesis via Ras1-PKA Signaling (2009) (295)
- Acquisition of Aneuploidy Provides Increased Fitness during the Evolution of Antifungal Drug Resistance (2009) (282)
- Stress, Drugs, and Evolution: the Role of Cellular Signaling in Fungal Drug Resistance (2008) (279)
- PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90 (2010) (259)
- Antifungal drug resistance: evolution, mechanisms and impact. (2018) (256)
- Hsp90 Governs Dispersion and Drug Resistance of Fungal Biofilms (2011) (240)
- Molecular Evolution of Antifungal Drug Resistance. (2017) (228)
- Evolution of Drug Resistance in Experimental Populations of Candida albicans (2000) (206)
- Global Gene Deletion Analysis Exploring Yeast Filamentous Growth (2012) (198)
- Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond. (2020) (188)
- Global analysis of fungal morphology exposes mechanisms of host cell escape (2015) (182)
- Threats Posed by the Fungal Kingdom to Humans, Wildlife, and Agriculture (2020) (163)
- Evolution of drug resistance in Candida albicans. (2002) (154)
- Global Analysis of the Evolution and Mechanism of Echinocandin Resistance in Candida glabrata (2012) (152)
- Mode of selection and experimental evolution of antifungal drug resistance in Saccharomyces cerevisiae. (2003) (152)
- Genetic Architecture of Hsp90-Dependent Drug Resistance (2006) (149)
- Population genomics of drug resistance in Candida albicans (2002) (143)
- Antifungal Drugs: The Current Armamentarium and Development of New Agents. (2016) (116)
- Hsp90 Orchestrates Stress Response Signaling Governing Fungal Drug Resistance (2009) (110)
- Divergence in Fitness and Evolution of Drug Resistance in Experimental Populations of Candida albicans (2001) (110)
- Mapping the Hsp90 Genetic Interaction Network in Candida albicans Reveals Environmental Contingency and Rewired Circuitry (2012) (108)
- Thermal Control of Microbial Development and Virulence: Molecular Mechanisms of Microbial Temperature Sensing (2012) (104)
- Hsp90 Orchestrates Transcriptional Regulation by Hsf1 and Cell Wall Remodelling by MAPK Signalling during Thermal Adaptation in a Pathogenic Yeast (2012) (100)
- Infrequent Genetic Exchange and Recombination in the Mitochondrial Genome of Candida albicans (2001) (95)
- Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs (2012) (88)
- Genetic and Genomic Architecture of the Evolution of Resistance to Antifungal Drug Combinations (2013) (87)
- Lysine Deacetylases Hda1 and Rpd3 Regulate Hsp90 Function thereby Governing Fungal Drug Resistance (2012) (85)
- The fungal Achilles' heel: targeting Hsp90 to cripple fungal pathogens. (2013) (80)
- Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans (2016) (79)
- The Hsp90 Co-Chaperone Sgt1 Governs Candida albicans Morphogenesis and Drug Resistance (2012) (76)
- Treatment strategies for cryptococcal infection: challenges, advances and future outlook (2021) (76)
- Genetic Analysis of Candida auris Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance (2019) (75)
- Elucidating drug resistance in human fungal pathogens. (2014) (74)
- Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms (2018) (74)
- Pho85, Pcl1, and Hms1 Signaling Governs Candida albicans Morphogenesis Induced by High Temperature or Hsp90 Compromise (2012) (72)
- Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation (2015) (71)
- The Candida albicans pescadillo homolog is required for normal hypha-to-yeast morphogenesis and yeast proliferation (2008) (63)
- Dual Action Antifungal Small Molecule Modulates Multidrug Efflux and TOR Signaling (2016) (63)
- Opportunistic yeast pathogens: reservoirs, virulence mechanisms, and therapeutic strategies (2015) (61)
- Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in Candida albicans (2012) (60)
- Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus (2019) (59)
- High-Throughput Screening Identifies Genes Required for Candida albicans Induction of Macrophage Pyroptosis (2018) (53)
- Fitness Trade-Offs Associated with the Evolution of Resistance to Antifungal Drug Combinations. (2015) (52)
- The Hsp90 Chaperone Network Modulates Candida Virulence Traits. (2017) (51)
- The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation (2017) (44)
- Membrane Fluidity and Temperature Sensing Are Coupled via Circuitry Comprised of Ole1, Rsp5, and Hsf1 in Candida albicans (2014) (43)
- Stress Adaptation. (2017) (43)
- Multilocus Genotypes and DNA Fingerprints Do Not Predict Variation in Azole Resistance among Clinical Isolates ofCandida albicans (1999) (43)
- Hsp90‐dependent regulatory circuitry controlling temperature‐dependent fungal development and virulence (2014) (42)
- Surviving the Heat of the Moment: A Fungal Pathogens Perspective (2013) (42)
- Beauvericin Potentiates Azole Activity via Inhibition of Multidrug Efflux, Blocks Candida albicans Morphogenesis, and Is Effluxed via Yor1 and Circuitry Controlled by Zcf29 (2016) (40)
- Coupling temperature sensing and development (2010) (39)
- Mapping the Hsp90 Genetic Network Reveals Ergosterol Biosynthesis and Phosphatidylinositol-4-Kinase Signaling as Core Circuitry Governing Cellular Stress (2016) (38)
- Using combination therapy to thwart drug resistance. (2015) (37)
- Metabolic control of antifungal drug resistance. (2010) (37)
- Progress and prospects for targeting Hsp90 to treat fungal infections (2014) (37)
- Functional Genomic Screening Reveals Core Modulators of Echinocandin Stress Responses in Candida albicans. (2018) (36)
- Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space (2018) (36)
- Design and synthesis of fungal-selective resorcylate aminopyrazole Hsp90 inhibitors. (2020) (34)
- Predicting the emergence of resistance to antifungal drugs. (2001) (31)
- Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis (2016) (31)
- Signaling through Lrg1, Rho1 and Pkc1 Governs Candida albicans Morphogenesis in Response to Diverse Cues (2016) (31)
- Integrin-based diffusion barrier separates membrane domains enabling the formation of microbiostatic frustrated phagosomes (2018) (30)
- Global proteomic analyses define an environmentally contingent Hsp90 interactome and reveal chaperone-dependent regulation of stress granule proteins and the R2TP complex in a fungal pathogen (2019) (30)
- Minimum Inhibitory Concentration (MIC) Assay for Antifungal Drugs (2012) (30)
- Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2. (2020) (29)
- Extensive functional redundancy in the regulation of Candida albicans drug resistance and morphogenesis by lysine deacetylases Hos2, Hda1, Rpd3 and Rpd31 (2017) (29)
- Multilocus Genotyping Indicates that the Ability To Invade the Bloodstream Is Widespread among Candida albicans Isolates (2001) (29)
- An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris (2020) (28)
- A small molecule produced by Lactobacillus species blocks Candida albicans filamentation by inhibiting a DYRK1-family kinase (2021) (27)
- Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs (2018) (25)
- Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2 (2017) (24)
- To Sense or Die: Mechanisms of Temperature Sensing in Fungal Pathogens (2014) (24)
- Uncovering cellular circuitry controlling temperature-dependent fungal morphogenesis (2012) (24)
- A Systems Biology Approach Reveals the Role of a Novel Methyltransferase in Response to Chemical Stress and Lipid Homeostasis (2011) (22)
- Functional Genomic Analysis of Candida albicans Adherence Reveals a Key Role for the Arp2/3 Complex in Cell Wall Remodelling and Biofilm Formation (2016) (22)
- Regulatory circuitry governing morphogenesis in Saccharomyces cerevisiae and Candida albicans (2012) (21)
- One Health: Fungal Pathogens of Humans, Animals, and Plants (2019) (21)
- Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris (2020) (21)
- The Proteasome Governs Fungal Morphogenesis via Functional Connections with Hsp90 and cAMP-Protein Kinase A Signaling (2020) (19)
- Environment-induced same-sex mating in the yeast Candida albicans through the Hsf1–Hsp90 pathway (2019) (19)
- Enhanced Efflux Pump Expression in Candida Mutants Results in Decreased Manogepix Susceptibility (2020) (18)
- Functional Divergence of Hsp90 Genetic Interactions in Biofilm and Planktonic Cellular States (2015) (18)
- Staurosporine Induces Filamentation in the Human Fungal Pathogen Candida albicans via Signaling through Cyr1 and Protein Kinase A (2017) (16)
- Regulation of the heat shock transcription factor Hsf1 in fungi: implications for temperature-dependent virulence traits (2018) (16)
- Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity. (2021) (14)
- Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets (2021) (14)
- Electron cryomicroscopy observation of acyl carrier protein translocation in type I fungal fatty acid synthase (2019) (13)
- Functional divergence of a global regulatory complex governing fungal filamentation (2019) (13)
- Functional connections between cell cycle and proteostasis in the regulation of Candida albicans morphogenesis (2021) (12)
- Structure-guided approaches to targeting stress responses in human fungal pathogens (2020) (10)
- Ydj 1 governs fungal morphogenesis and stress response , and facilitates mitochondrial protein import via Mas 1 and Mas 2 (2017) (10)
- Erratum for Kim et al., “Genetic Analysis of Candida auris Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance” (2019) (10)
- Insights into the host-pathogen interaction: C. albicans manipulation of macrophage pyroptosis (2018) (10)
- The role of Candida albicans stress response pathways in antifungal tolerance and resistance (2022) (9)
- Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation (2022) (8)
- Advances in fungal chemical genomics for the discovery of new antifungal agents (2020) (8)
- Oxadiazole-Containing Macrocyclic Peptides Potentiate Azole Activity against Pathogenic Candida Species (2020) (8)
- Candida albicans Is Resistant to Polyglutamine Aggregation and Toxicity (2016) (7)
- The macrophage-derived protein PTMA induces filamentation of the human fungal pathogen Candida albicans (2021) (6)
- A novel calcineurin-independent activity of cyclosporin A in Saccharomyces cerevisiae. (2012) (5)
- Deep tissue infection by an invasive human fungal pathogen requires novel lipid-based suppression of the IL-17 response (2022) (5)
- Bacterial-Fungal Interactions and Their Impact on Microbial Pathogenesis. (2022) (4)
- Mitochondrial perturbation reduces susceptibility to xenobiotics through altered efflux in Candida albicans. (2021) (4)
- Antifungal drug resistance: Deciphering the mechanisms governing multidrug resistance in the fungal pathogen Candida glabrata (2021) (4)
- Editorial: Antifungal Pipeline: Build It Strong; Build It Better! (2022) (4)
- Genetic analysis of Hsp90 function in Cryptococcus neoformans highlights key roles in stress tolerance and virulence (2021) (4)
- Inhibiting Protein Prenylation with Benzoxaboroles to Target Fungal Plant Pathogens. (2020) (4)
- Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance (2022) (4)
- The Canadian Fungal Research Network: current challenges and future opportunities. (2020) (4)
- Evolution of Drug Resistance in Fungi (2013) (3)
- Defining the Yeast Resistome through in vitro Evolution and Whole Genome Sequencing (2021) (3)
- Functional analysis of the Candida albicans kinome reveals Hrr25 as a regulator of antifungal susceptibility (2022) (3)
- The Rise of Fungi: A Report on the CIFAR Program Fungal Kingdom: Threats & Opportunities Inaugural Meeting (2020) (3)
- Antifungal discovery. (2022) (3)
- Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III. (2021) (3)
- Antifungal Activity of Gepinacin Scaffold Glycosylphosphatidylinositol Anchor Biosynthesis Inhibitors with Improved Metabolic Stability (2020) (3)
- Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III (2021) (3)
- The Candida albicans Hsp90 Chaperone Network Is Environmentally Flexible and Evolutionarily Divergent (2014) (2)
- A functionally divergent intrinsically disordered region underlying the conservation of stochastic signaling (2021) (2)
- Exploring Boron Applications in Modern Agriculture: A Structure-Activity Relationship Study of a Novel Series of Multi-Substitution Benzoxaboroles for Identification of Potential Fungicides. (2021) (2)
- Faculty Opinions recommendation of CO2 Signaling through the Ptc2-Ssn3 Axis Governs Sustained Hyphal Development of Candida albicans by Reducing Ume6 Phosphorylation and Degradation. (2019) (2)
- The future of fungi: threats and opportunities (2022) (2)
- Calcineurin Inhibitors Synergize with Manogepix to Kill Diverse Human Fungal Pathogens (2022) (1)
- Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus (2019) (1)
- Protein-Protein Interaction Profiling in Candida albicans Revealed by Biochemical Purification-Mass Spectrometry (BP/MS). (2019) (1)
- PLOS Pathogens 2016 Reviewer and Editorial Board Thank You (2017) (1)
- Flow Cytometric Measurement of Efflux in Candida Species (2020) (1)
- The GARP complex is required for filamentation in Candida albicans. (2022) (1)
- Faculty Opinions recommendation of Quorum sensing controls hyphal initiation in Candida albicans through Ubr1-mediated protein degradation. (2014) (1)
- Faculty of 1000 evaluation for Xylose donor transport is critical for fungal virulence. (2018) (1)
- Faculty Opinions recommendation of Development of Anti-Virulence Approaches for Candidiasis via a Novel Series of Small-Molecule Inhibitors of Candida albicans Filamentation. (2017) (1)
- Molecular analysis and essentiality of Aro1 shikimate biosynthesis multi-enzyme in Candida albicans (2022) (1)
- Glycosylated Polyene Macrolides Kill Fungi via a Conserved Sterol Sponge Mechanism of Action (2021) (1)
- High-Throughput Chemical Screen Identifies a 2,5-Disubstituted Pyridine as an Inhibitor of Candida albicans Erg11 (2022) (1)
- Faculty Opinions recommendation of A tetraploid intermediate precedes aneuploid formation in yeasts exposed to fluconazole. (2014) (0)
- Genomic Approaches to Antifungal Drug Target Identification and Validation. (2022) (0)
- Chemical-Genetic Approaches for Exploring Mode of Action of Antifungal Compounds in the Fungal Pathogen Candida albicans. (2023) (0)
- Faculty Opinions recommendation of Experimental evolution of a fungal pathogen into a gut symbiont. (2018) (0)
- Exploiting diverse chemical collections to uncover novel antifungals (2021) (0)
- Ent2 Governs Morphogenesis and Virulence in Part through Regulation of the Cdc42 Signaling Cascade in the Fungal Pathogen Candida albicans (2023) (0)
- Showcasing Fungal Genetics & Genomics with the Genetics Society of America (2021) (0)
- 1011 Potent antifungal activity of pentagalloyl glucose against drug-resistant candida albicans, candida auris, and other non-albicans candida species (2023) (0)
- Inhibiting C-4 Methyl Sterol Oxidase with Novel Diazaborines to Target Fungal Plant Pathogens. (2022) (0)
- Exploring Space via Astromycology: A Report on the CIFAR Programs Earth 4D and Fungal Kingdom Inaugural Joint Meeting. (2022) (0)
- Faculty Opinions recommendation of Fungal kinases and transcription factors regulating brain infection in Cryptococcus neoformans. (2020) (0)
- Modelling the regulation of thermal adaptation by Hsf1 and Hsp90 in Candida albicans (2011) (0)
- Identification and characterization of a fungal-selective glutaminyl tRNA synthetase inhibitor with potent activity against Candida albicans (2021) (0)
- Author response: Integrin-based diffusion barrier separates membrane domains enabling the formation of microbiostatic frustrated phagosomes (2018) (0)
- The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation (2017) (0)
- Faculty Opinions recommendation of Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol. (2020) (0)
- Faculty Opinions recommendation of Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis. (2019) (0)
- Showcasing Fungal Genetics & Genomics with the Genetics Society of America. (2021) (0)
- The Trisubstituted Isoxazole MMV688766 Exerts Broad-Spectrum Activity against Drug-Resistant Fungal Pathogens through Inhibition of Lipid Homeostasis (2022) (0)
- Faculty Opinions recommendation of Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance. (2016) (0)
- Faculty Opinions recommendation of Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection. (2018) (0)
- Opportunistic yeast pathogens: reservoirs, virulence mechanisms, and therapeutic strategies (2015) (0)
- Fluorescence Polarization‐Based Measurement of Protein‐Ligand Interaction in Fungal Cell Lysates (2021) (0)
- Faculty Opinions recommendation of Selection of Candida albicans trisomy during oropharyngeal infection results in a commensal-like phenotype. (2019) (0)
- Membrane fluidity and temperature sensing are coupled (2014) (0)
- Faculty Opinions recommendation of Immunological consequences of intestinal fungal dysbiosis. (2016) (0)
- Selective Control of Parasitic Nematodes Using Bioactivated Nematicides (2022) (0)
- Construction of Candida albicans Strains with ATP-Analog-Sensitive Protein Kinase A and Hog1 (2023) (0)
- Faculty Opinions recommendation of Generating genomic platforms to study Candida albicans pathogenesis. (2018) (0)
- Microevolution of Antifungal Drug Resistance (2014) (0)
- Faculty Opinions recommendation of Amphibian fungal panzootic causes catastrophic and ongoing loss of biodiversity. (2019) (0)
- Faculty Opinions recommendation of Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformans. (2016) (0)
- Drugs from bugs in creatures of the sea (2020) (0)
- Faculty Opinions recommendation of Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistance. (2020) (0)
- Faculty Opinions recommendation of Comparative phenotypic analysis of the major fungal pathogens Candida parapsilosis and Candida albicans. (2014) (0)
- Faculty Opinions recommendation of Bacterial-fungal interactions revealed by genome-wide analysis of bacterial mutant fitness. (0)
- Faculty Opinions recommendation of The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL. (2019) (0)
- Drug Combinations as a Strategy to Potentiate Existing Antifungal Agents (2015) (0)
- Faculty Opinions recommendation of Neutrophil Attack Triggers Extracellular Trap-Dependent Candida Cell Wall Remodeling and Altered Immune Recognition. (2016) (0)
- Faculty Opinions recommendation of Fungal biofilm morphology impacts hypoxia fitness and disease progression. (2020) (0)
- Functional genomic analysis of Candida albicans protein kinases reveals modulators of morphogenesis in diverse environments (2023) (0)
- Faculty Opinions recommendation of Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus. (2018) (0)
- Faculty Opinions recommendation of Malassezia Is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Models. (2019) (0)
- Faculty Opinions recommendation of Candida glabrata Binding to Candida albicans Hyphae Enables Its Development in Oropharyngeal Candidiasis. (2016) (0)
- Faculty Opinions recommendation of Zinc finger transcription factors displaced SREBP proteins as the major Sterol regulators during Saccharomycotina evolution. (2014) (0)
- Faculty Opinions recommendation of Iron restriction inside macrophages regulates pulmonary host defense against Rhizopus species. (2018) (0)
- Downregulation of Essential Genes in the Fungal Pathogen Candida auris. (2022) (0)
- Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance (2022) (0)
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