Lee Zou
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Lee Zou's AcademicInfluence.com Rankings
Lee Zouengineering Degrees
Engineering
#6402
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#7727
Historical Rank
Biomedical Engineering
#565
World Rank
#575
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Electrical Engineering
#1902
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#2004
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Applied Physics
#2037
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#2074
Historical Rank
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Engineering
Lee Zou's Degrees
- Masters Electrical Engineering Stanford University
Why Is Lee Zou Influential?
(Suggest an Edit or Addition)Lee Zou's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes (2003) (2643)
- A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations (2010) (2088)
- DNA damage sensing by the ATM and ATR kinases. (2013) (1016)
- Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. (2002) (546)
- Replication protein A-mediated recruitment and activation of Rad17 complexes (2003) (454)
- m6A RNA methylation regulates the UV-induced DNA damage response (2017) (440)
- Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors (2015) (373)
- Assembly of a Complex Containing Cdc45p, Replication Protein A, and Mcm2p at Replication Origins Controlled by S-Phase Cyclin-Dependent Kinases and Cdc7p-Dbf4p Kinase (2000) (371)
- Checking on the fork: the DNA-replication stress-response pathway. (2002) (370)
- Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks. (2009) (365)
- Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin. (1998) (356)
- Regulation of homologous recombination by RNF20-dependent H2B ubiquitination. (2011) (323)
- RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response (2014) (311)
- TERRA and hnRNPA1 Orchestrate an RPA-to-POT1 Switch on Telomeric Single-Stranded DNA (2010) (308)
- Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain (2017) (277)
- ATR: a master conductor of cellular responses to DNA replication stress. (2011) (274)
- ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells (2017) (261)
- MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells (2017) (254)
- ATR autophosphorylation as a molecular switch for checkpoint activation. (2011) (253)
- Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase. (2015) (230)
- CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. (2010) (220)
- PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (2014) (200)
- A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation (2018) (184)
- Molecular Pathways: Targeting ATR in Cancer Therapy (2015) (184)
- CDC45, a novel yeast gene that functions with the origin recognition complex and Mcm proteins in initiation of DNA replication (1997) (181)
- Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features (2019) (180)
- Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1. (2017) (168)
- Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians (2010) (158)
- Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways (2019) (154)
- Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress. (2006) (141)
- Functions, Regulation, and Therapeutic Implications of the ATR Checkpoint Pathway. (2016) (135)
- Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response. (2012) (130)
- Chk1 and Claspin potentiate PCNA ubiquitination. (2008) (127)
- Sensing, signaling, and responding to DNA damage: Organization of the checkpoint pathways in mammalian cells (2005) (127)
- Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1. (2013) (125)
- Coupling of Homologous Recombination and the Checkpoint by ATR. (2017) (125)
- The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response. (2010) (123)
- Single- and double-stranded DNA: building a trigger of ATR-mediated DNA damage response. (2007) (113)
- ATRIP associates with replication protein A-coated ssDNA through multiple interactions. (2006) (108)
- Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes. (2018) (92)
- The CHK1 Inhibitor Prexasertib Exhibits Monotherapy Activity in High-Grade Serous Ovarian Cancer Models and Sensitizes to PARP Inhibition (2019) (88)
- Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses (2011) (87)
- ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB (2018) (86)
- Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition. (2016) (84)
- Suppression of genome instability in pRB-deficient cells by enhancement of chromosome cohesion. (2014) (77)
- APOBEC3A and APOBEC3B Activities Render Cancer Cells Susceptible to ATR Inhibition. (2017) (75)
- Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance. (2015) (70)
- ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop. (2019) (70)
- Genomic instability and endoreduplication triggered by RAD17 deletion. (2003) (69)
- ATR signaling at a glance (2009) (69)
- NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis. (2011) (68)
- Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma (2019) (68)
- Analysis of DNA Damage Response Gene Alterations and Tumor Mutational Burden Across 17,486 Tubular Gastrointestinal Carcinomas: Implications for Therapy. (2019) (64)
- Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks (2020) (61)
- Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers (2017) (61)
- Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor. (2013) (58)
- m5C modification of mRNA serves a DNA damage code to promote homologous recombination (2020) (57)
- cGAS suppresses genomic instability as a decelerator of replication forks (2020) (54)
- SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway (2014) (53)
- Detection of Impaired Homologous Recombination Repair in NSCLC Cells and Tissues (2013) (52)
- Nek1 kinase associates with ATR–ATRIP and primes ATR for efficient DNA damage signaling (2013) (51)
- RNA transcripts stimulate homologous recombination by forming DR-loops (2021) (50)
- An R-loop-initiated CSB–RAD52–POLD3 pathway suppresses ROS-induced telomeric DNA breaks (2019) (46)
- Direct Role for Proliferating Cell Nuclear Antigen in Substrate Recognition by the E3 Ubiquitin Ligase CRL4Cdt2* (2012) (45)
- Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots (2020) (44)
- Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells. (2021) (42)
- Dual functions of DNA replication forks in checkpoint signaling and PCNA ubiquitination (2009) (39)
- Recruitment of ATR-ATRIP, Rad17, and 9-1-1 complexes to DNA damage. (2006) (39)
- An extended APOBEC3A mutation signature in cancer (2021) (37)
- Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies. (2021) (37)
- SCFβ-TRCP promotes cell growth by targeting PR-Set7/Set8 for degradation (2015) (36)
- CARM1 regulates replication fork speed and stress response by stimulating PARP1. (2020) (35)
- Potentiated DNA Damage Response in Circulating Breast Tumor Cells Confers Resistance to Chemotherapy* (2015) (35)
- The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression. (2014) (35)
- MRE 11 and EXO 1 nucleases degrade reversed forks and elicit MUS 81-dependent fork rescue in BRCA 2-de fi cient cells (2017) (34)
- EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity. (2013) (30)
- Faculty Opinions recommendation of DNA-repair scaffolds dampen checkpoint signalling by counteracting the adaptor Rad9. (2012) (30)
- Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference (2019) (29)
- RPA and POT1 (2012) (27)
- Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids (2022) (26)
- Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium. (2019) (25)
- The trans cell cycle effects of PARP inhibitors underlie their selectivity toward BRCA1/2-deficient cells (2021) (25)
- ATR-p53 Restricts Homologous Recombination in Response to Replicative Stress but Does Not Limit DNA Interstrand Crosslink Repair in Lung Cancer Cells (2011) (25)
- Hallmarks of DNA replication stress. (2022) (24)
- A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination (2017) (24)
- The conserved C terminus of Claspin interacts with Rad9 and promotes rapid activation of Chk1 (2012) (24)
- Corrigendum: RNA m6A methylation regulates the ultraviolet-induced DNA damage response (2017) (22)
- Four pillars of the S-phase checkpoint. (2013) (21)
- Targeting Homologous Recombination Repair in Cancer (2012) (20)
- The SUMO (Small Ubiquitin-like Modifier) Ligase PIAS3 Primes ATR for Checkpoint Activation* (2015) (20)
- Checkpoint and coordinated cellular responses to DNA damage. (2006) (19)
- BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency (2020) (19)
- The BRUCE‐ATR Signaling Axis Is Required for Accurate DNA Replication and Suppression of Liver Cancer Development (2019) (18)
- An extending ATR-CHK1 circuitry: the replication stress response and beyond. (2021) (16)
- E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression. (2017) (16)
- BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage (2021) (16)
- CDC7-independent G1/S transition revealed by targeted protein degradation (2022) (16)
- Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination (2018) (15)
- Prevalence and Functional Analysis of Sequence Variants in the ATR Checkpoint Mediator Claspin (2009) (15)
- Sensing and signaling DNA damage: roles of Rad17 and Rad9 complexes in the cellular response to DNA damage. (2001) (15)
- DNA Replication Checkpoint: New ATR Activator Identified (2017) (14)
- Regulation of DNA break repair by transcription and RNA (2017) (12)
- Inhibition of ATR-Chk1 signaling blocks DNA double-strand-break repair and induces cytoplasmic vacuolization in metastatic osteosarcoma (2020) (11)
- DNA repair defects in cancer and therapeutic opportunities (2022) (11)
- FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation (2022) (10)
- TERRA and RAD51AP1 promote alternative lengthening of telomeres through an R- to D-loop switch. (2022) (9)
- Induction of BRCAness in Triple-Negative Breast Cancer by a CDK12/13 Inhibitor Improves Chemotherapy. (2019) (9)
- Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells (2020) (9)
- Active RB causes visible changes in nuclear organization (2022) (8)
- Targeting R-loop-associated ATR response in myelodysplastic syndrome (2019) (8)
- APOBEC3A drives acquired resistance to targeted therapies in non-small cell lung cancer (2021) (8)
- Identification of Somatically Acquired BRCA1/2 Mutations by cfDNA Analysis in Patients with Metastatic Breast Cancer (2020) (8)
- Targeting the DNA replication stress phenotype of KRAS mutant cancer cells (2021) (7)
- NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer. (2021) (7)
- Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer (2021) (7)
- Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells. (2020) (7)
- Impacts of chromatin dynamics and compartmentalization on DNA repair. (2021) (6)
- A human cell extract-based assay for the activation of ATM and ATR checkpoint kinases. (2011) (6)
- DNA repair: A protein giant in its entirety (2010) (6)
- Launching a ubiquitination cascade at DNA breaks (2007) (5)
- MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells (2017) (5)
- Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer (2022) (4)
- A genome-wide and cotranscriptional suppressor of R loops (2020) (4)
- Condensates induced by transcription inhibition localize active chromatin to nucleoli. (2022) (4)
- Checkpoint Mec-tivation comes in many flavors. (2009) (4)
- Abstract PR09: Cancer-specific retargeting of BAF complexes by a prion-like domain (2018) (3)
- RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer (2021) (3)
- CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer (2022) (3)
- Erratum: Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination. (2019) (3)
- Calcium Influx Guards Replication Forks against Exonuclease 1. (2019) (2)
- Co-regulation and functional cooperativity of FOXM1 and RHNO1 bidirectional genes in ovarian cancer (2019) (2)
- DNA Damage: Sensing (2008) (2)
- RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair (2021) (2)
- Spliceosomal Mutations Induce R Loop-Associated ATR Signaling (2017) (2)
- RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer (2022) (2)
- Ataxia Telangiectasia-Mutated and Rad3-Related Inhibition and Topoisomerase I Trapping Create a Synthetic Lethality in Cancer Cells. (2018) (1)
- The 2015 Albert Lasker Basic Medical Research Award: An exhilarating journey to the DNA damage checkpoint (2015) (1)
- m 6 A RNA methylation regulates the UV-induced DNA damage response (2017) (1)
- Faculty Opinions recommendation of A mechanism for the suppression of homologous recombination in G1 cells. (2015) (1)
- Oncogenic KIT Induces Replication stress and Confers Cell Cycle Checkpoint Vulnerability in Melanoma. (2021) (1)
- Sensing of DNA breaks by the ATM and ATR checkpoint kinases (2013) (1)
- An extended APOBEC3A mutation signature in (2021) (1)
- A LARGe surprise links ATR and Rho (2014) (1)
- Getting a Genomic View of DNA Replication Stress. (2018) (1)
- A Zygotic Checkpoint for Unrepaired Lesions (2016) (1)
- NR4A1 suppresses cancer replication stress through R-loop-dependent inhibition of immediate early gene transcriptional elongation (2020) (0)
- Faculty Opinions recommendation of BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation. (2019) (0)
- CDC7-independent G1/S transition revealed by targeted protein degradation (2022) (0)
- A non-canonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML. (2023) (0)
- Abstract 6101: PUM3 is a novel R-loop regulator and is essential for efficient DNA damage repair (2023) (0)
- Supplemental Information Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition (2016) (0)
- Abstract A04: Phosphorylation and ubiquitylation on the RPA-ssDNA platform promote homologous recombination (2017) (0)
- Therapeutics , Targets , and Chemical Biology EGFR-Activating Mutations Correlate with a Fanconi Anemia – likeCellular Phenotype That Includes PARP Inhibitor Sensitivity (2013) (0)
- RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair. (2022) (0)
- Author Correction: Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids (2022) (0)
- Recombinational DNA Repair Defects in Lung Cancer and PARP Inhibitor Sensitivity (2012) (0)
- Targeting the APOBEC3B-Induced Mutation Showers in Breast Cancer (2015) (0)
- Faculty Opinions recommendation of Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast. (2011) (0)
- Abstract MS2-1: MS2-1 Targeting the ATR checkpoint in cancer therapy (2017) (0)
- Faculty Opinions recommendation of Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling. (2014) (0)
- Faculty Opinions recommendation of Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11. (2011) (0)
- Signaling of DNA Replication Stress Through the ATR Checkpoint (2016) (0)
- Author Correction: Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids (2022) (0)
- Author response: Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer (2021) (0)
- Faculty Opinions recommendation of Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability. (2015) (0)
- Protocol to stimulate and delineate alternative lengthening of telomeres in human U2OS cells (2022) (0)
- Autophagy and Tamoxifen Resistance in Breast Cancer. (2009) (0)
- Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma (2019) (0)
- ATR Expression as a Prognostic Biomarker and Therapeutic Target in Metastatic Osteosarcoma (2020) (0)
- Revealing the DNA Structural Determinants for ATM Activation (2009) (0)
- Abstract 6195: Assessing replication stress as an actionable therapeutic opportunity in chordoma (2023) (0)
- Abstract GMM-034: CO-REGULATION AND FUNCTIONAL COOPERATIVITY BETWEEN FOXM1 AND RHNO1 BIDIRECTIONAL GENES IN HIGH-GRADE SEROUS OVARIAN CANCER (2019) (0)
- Faculty Opinions recommendation of ATM activation by oxidative stress. (2010) (0)
- EVIDENCE OF TRANSCRIPTION-FACILITATED DSB REPAIR (2017) (0)
- Chabner Colloquium: Answering the Big Questions in Cancer Research & 2017 STO Annual Meeting (2017) (0)
- The 2015 Albert Lasker Basic Medical Research Award: An exhilarating journey to the DNA damage checkpoint (2015) (0)
- Ectopic Expression of the Meiotic Protein SYCP2 in Breast Cancer Promotes Homologous Recombination and Endows Broad Resistance to DNA Repair-Targeted Drugs (2020) (0)
- Abstract B18: Mechanisms of regulation and synthetic lethal strategies against PALB2 and APRIN, two DNA double-strand break repair proteins (2017) (0)
- Faculty Opinions recommendation of Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. (2010) (0)
- PRP19 Transforms into a Sensor of RPA-ssDNA after DNA Damage and Drives ATR Activation via a Ubiquitin-Mediated Circuitry (2014) (0)
- Single-and double-stranded DNA : building a trigger of ATR-mediated DNA damage response (2007) (0)
- Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks (2020) (0)
- Critical Questions in Ovarian Cancer Research and Treatment: Report of an AACR Special Conference (2019) (0)
- Abstract MIP-049: ATR–DEPENDENT REGULATION OF THE OVARIAN CANCER PROTEIN PALB2 AT DNA DOUBLE–STRAND BREAKS (2017) (0)
- Abstract 1410: Proliferation during epithelial-to-mesenchymal transition induces genomic instability (2017) (0)
- Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots (2020) (0)
- Regulation of DNA break repair by transcription and RNA (2017) (0)
- Defective replication stress response linked to microcephaly (2022) (0)
- Abstract PR01: Mechanisms of regulation of the tumor suppressor PALB2 (2017) (0)
- Alternative Lengthening o f Telomeres through Two Distinct Break-Induced Replication Pathways Graphical (2019) (0)
- Tumor Suppressor ARID1A Deficiency Impairs DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors (2018) (0)
- Abstract 1358: Discovery and optimization of potent and selective benzonaphthyridinone analogs as dual mTOR/ATR small molecular inhibitors for treatment of cancer (2011) (0)
- ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB (2018) (0)
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What Schools Are Affiliated With Lee Zou?
Lee Zou is affiliated with the following schools:
