Leemor Joshua-Tor
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Israeli American professor of structural biology
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Leemor Joshua-Torbiology Degrees
Biology
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Molecular Biology
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Biology
Leemor Joshua-Tor's Degrees
- PhD Biophysics Weizmann Institute of Science
- Bachelors Chemistry Tel Aviv University
Why Is Leemor Joshua-Tor Influential?
(Suggest an Edit or Addition)According to Wikipedia, Leemor Joshua-Tor is the W.M. Keck Professor of Structural Biology at Cold Spring Harbor Laboratory and a Howard Hughes Medical Institute Investigator. Her research focuses on the role of the argonaute complex in RNA interference.
Leemor Joshua-Tor's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Argonaute2 Is the Catalytic Engine of Mammalian RNAi (2004) (2686)
- Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity (2004) (1471)
- Purified Argonaute2 and an siRNA form recombinant human RISC (2005) (756)
- Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi (2006) (631)
- The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes (2003) (590)
- Mechanism of DNA translocation in a replicative hexameric helicase (2006) (513)
- The Structure of Human Argonaute-2 in Complex with miR-20a (2012) (433)
- Slicer and the argonautes. (2007) (431)
- A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails. (2012) (359)
- The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis (2012) (300)
- Structural Basis for the EBA-175 Erythrocyte Invasion Pathway of the Malaria Parasite Plasmodium falciparum (2005) (286)
- Strategies for protein coexpression in Escherichia coli (2006) (239)
- Argonaute Slicing Is Required for Heterochromatic Silencing and Spreading (2006) (222)
- On helicases and other motor proteins. (2008) (194)
- From guide to target: molecular insights into eukaryotic RNA-interference machinery (2015) (178)
- X‐ray crystal structures of the oxidized and reduced forms of the rubredoxin from the marine hyperthermophilic archaebacterium pyrococcus furiosus (1992) (160)
- Conformational variability in structures of the nitrogenase iron proteins from Azotobacter vinelandii and Clostridium pasteurianum. (1998) (131)
- Crystal structure of a conserved protease that binds DNA: the bleomycin hydrolase, Gal6 (1995) (127)
- The making of a slicer: activation of human Argonaute-1. (2013) (126)
- NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler. (2015) (116)
- Mechanism of Dis3L2 substrate recognition in the Lin28/let-7 pathway (2014) (108)
- High-affinity binding of Chp1 chromodomain to K9 methylated histone H3 is required to establish centromeric heterochromatin. (2009) (107)
- Argonautes confront new small RNAs. (2007) (97)
- Ancestral roles of small RNAs: an Ago-centric perspective. (2011) (92)
- Argonaute and RNA--getting into the groove. (2006) (90)
- Crystal structure of the DNA binding domain of the replication initiation protein E1 from papillomavirus. (2000) (90)
- Eukaryotic Argonautes come into focus. (2013) (87)
- The Structure of Human Argonaute-2 in Complex with miR-20a (2012) (83)
- The three-dimensional structure of a DNA duplex containing looped-out bases (1988) (81)
- PTEN functions by recruitment to cytoplasmic vesicles. (2015) (75)
- Crystal structures of two intermediates in the assembly of the papillomavirus replication initiation complex (2002) (75)
- Crystal structure of Apaf-1 caspase recruitment domain: an alpha-helical Greek key fold for apoptotic signaling. (1999) (74)
- Three-dimensional structures of bulge-containing DNA fragments. (1992) (70)
- Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease. (1999) (66)
- Dynamic look at DNA unwinding by a replicative helicase (2014) (66)
- Multivalent Recruitment of Human Argonaute by GW182. (2017) (64)
- On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme (2015) (62)
- FUS Regulates Activity of MicroRNA-Mediated Gene Silencing. (2018) (59)
- Slicer and the Argonautes (2014) (58)
- NADP Regulates the Yeast GAL Induction System (2008) (51)
- The Unusual Active Site of Gal6/Bleomycin Hydrolase Can Act as a Carboxypeptidase, Aminopeptidase, and Peptide Ligase (1998) (49)
- siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2 (2016) (48)
- Increasing gender diversity in the STEM research workforce (2019) (46)
- The Argonautes. (2006) (46)
- Chd5 requires PHD-mediated histone 3 binding for tumor suppression. (2013) (45)
- Structure of the active form of human origin recognition complex and its ATPase motor module (2017) (45)
- High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations (2019) (41)
- The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS (2011) (40)
- Decoding the 5′ nucleotide bias of PIWI-interacting RNAs (2019) (40)
- Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development (2018) (40)
- Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis (2017) (40)
- Structural Basis for the EBA-175 Erythrocyte Invasion Pathway of the Malaria Parasite Plasmodium falciparum (2005) (39)
- ELTA: Enzymatic Labeling of Terminal ADP-Ribose. (2019) (39)
- Noncysteinyl coordination to the [4Fe-4S]2+ cluster of the DNA repair adenine glycosylase MutY introduced via site-directed mutagenesis. Structural characterization of an unusual histidinyl-coordinated cluster. (2002) (36)
- The Gal3p transducer of the GAL regulon interacts with the Gal80p repressor in its ligand-induced closed conformation. (2012) (36)
- Conformational substates in different crystal forms of the photoactive yellow protein—Correlation with theoretical and experimental flexibility (2008) (34)
- Essential dynamics from NMR clusters: dynamic properties of the Myb DNA-binding domain and a hinge-bending enhancing variant. (1998) (34)
- Comparison of the X‐ray structure of native rubredoxin from pyrococcus furiosus with the NMR structure of the zinc‐substituted protein (1992) (33)
- Structurally modulated codelivery of siRNA and Argonaute 2 for enhanced RNA interference (2018) (31)
- A structural snapshot of base-pair opening in DNA. (1999) (26)
- Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis (2017) (26)
- The DNA-binding Domain of Human Papillomavirus Type 18 E1 (2004) (24)
- CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing (2014) (22)
- Crystal structure of carboxypeptidase A complexed with D-cysteine at 1.75 A - inhibitor-induced conformational changes. (2000) (21)
- Argonaute MID domain takes centre stage (2010) (21)
- Selective chemical inactivation of AAA proteins reveals distinct functions of proteasomal ATPases. (2001) (18)
- The dynamic nature of the human origin recognition complex revealed through five cryoEM structures (2020) (15)
- Structure of the photoactive yellow protein reconstituted with caffeic acid at 1.16 A resolution. (2002) (14)
- Evolution of DNA replication origin specification and gene silencing mechanisms (2020) (14)
- Engineering Photocycle Dynamics (2002) (13)
- OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage (2022) (13)
- Mutagenesis and crystallographic studies of the catalytic residues of the papain family protease bleomycin hydrolase: new insights into active-site structure. (2007) (13)
- A structural view of the initiators for chromosome replication. (2018) (10)
- Asterix/Gtsf1 links tRNAs and piRNA silencing of retrotransposons (2020) (9)
- The coming of age of DMA crystallography (1993) (9)
- siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2 (2016) (8)
- siRNAs at RISC. (2004) (8)
- A structural model for sequence-specific proflavin-DNA interactions during in vitro frameshift mutagenesis. (1992) (6)
- Crystal Structures of the Iron Protein and Molybdenum-Iron Protein of Nitrogenase (1993) (5)
- Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release (2022) (4)
- CRYSTAL STRUCTURES AND KINETICS OF THREE PHOTOACTIVE YELLOW PROTEIN HINGE-BENDING MUTANTS* (2002) (4)
- , RNAi Argonaute 2 Is the Catalytic Engine of Mammalian (2009) (3)
- ETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation (2023) (2)
- HUMAN BLEOMYCIN HYDROLASE. (2000) (2)
- The Bleomycin Hydrolases (1998) (2)
- Antibody Testing Documents the Silent Spread of SARS-CoV-2in New York Prior to the First Reported Case (2020) (2)
- A circadian-like gene network regulates heterochronic miRNA transcription in C. elegans (2023) (2)
- HUMAN BLEOMYCIN HYDROLASE, C73S/DELE455 MUTANT (2000) (1)
- Developmental roles and molecular mechanisms of Asterix/GTSF1 (2022) (1)
- The Crystal Structure of the Argonaute2 PAZ domain (as a MBP fusion) (2004) (1)
- Structure of the active form of human Origin Recognition Complex ATPase motor module, complex subunitS 1, 4, 5 (2017) (1)
- Heterologous Expression and Purification of SARS-CoV2 Nucleocapsid Protein (2020) (1)
- Crystal structure of full length Argonaute from Pyrococcus furiosus (2004) (1)
- CARBOXYPEPTIDASE A COMPLEX WITH D-CYSTEINE AT 1.75 A (2000) (1)
- Structure of P.furiosus Argonaute with bound Mn2 (2005) (0)
- Crystal structure of EBA-175 Region II (RII) (2005) (0)
- Decoding the 5′ nucleotide bias of PIWI-interacting RNAs (2019) (0)
- NITROGENASE IRON PROTEIN FROM CLOSTRIDIUM PASTEURIANUM (1998) (0)
- NMR and X-ray crystallographic studies of the binding of chiral metal complexes to oligonucleotides (1991) (0)
- Abstract LB-063: PTEN function is controlled by recruitment to cytoplasmic vesicles (2015) (0)
- Talk from Leemor Joshua-Tor at the Cold Spring Harbor Laboratory In-House Symposium (2011). (2011) (0)
- Structure of human TUT7 catalytic module (CM) in complex with U5 RNA (2017) (0)
- Crystal structure of the Chp1-Tas3 complex core (2011) (0)
- Bleomycin hydrolase, a new family of cysteine peptidases reveal a novel mechanism of peptide degradation (1997) (0)
- GAL6 (YEAST BLEOMYCIN HYDROLASE) MUTANT C73A (1998) (0)
- NMR solution structure of Asterix/Gtsf1 from mouse (CHHC zinc finger domains) (2021) (0)
- Crystal structure of Zucchini from mouse (mZuc / PLD6 / MitoPLD) bound to tungstate (2012) (0)
- ORC-O1AAA: Human Origin Recognition Complex (ORC) with dynamic/unresolved ORC2 WH (2020) (0)
- Participation of the iron-sulfur cluster loop (FCL) motif of the adenine glycosylase MutY in DNA damage recognition and repair (2001) (0)
- Mechanisms of RNAi: a molecular view or Argonaute: the secret life of Slicer (2007) (0)
- Crystal structure of the unliganded form of Gal3p (2012) (0)
- Crystal structure of the yeast GAL regulon complex of the repressor, Gal80p, and the transducer, Gal3p, with galactose and ATP (2012) (0)
- Crystal structure of single chain variable fragment (scFv45). (2018) (0)
- Structure of Dos1 propeller (2014) (0)
- Asymmetric focsued reconstruction of human norovirus GII.2 Snow Mountain Virus strain VLP asymmetric unit in T=1 symmetry (2019) (0)
- Structure of Pyrococcus furiosus Argonaute with bound tungstate (2005) (0)
- Erratum: CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing (Proceedings of the National Academy of Sciences of the United States of America (2014) 111 (1795-1800) DOI: 10.1073/pnas.1313096111) (2014) (0)
- ORC-O2-5: Human Origin Recognition Complex (ORC) with subunits 2,3,4,5 (2020) (0)
- Crystal Structure of a Mutant of MutY Catalytic Domain (2002) (0)
- Establishment of a non-radioactive assay to measure RISC (RNA-induced silencing complex) activity in vitro (2008) (0)
- Argonaute-2 - 5'-(E)-vinylphosphonate 2'-O-methyl-uridine modified mrTTR guide RNA complex (2016) (0)
- Mechanisms of Phosphorylation‐Mediated Regulation of the RNAi Effector Protein Argonaute 2 (2020) (0)
- ORC-DNA: Human Origin Recognition Complex (ORC) with DNA bound in the core (2020) (0)
- Human Origin Recognition Complex subunits 2 and 3 (2017) (0)
- Human Argonaute-2 - miR-20a complex (2012) (0)
- ORC-OPEN: Human Origin Recognition Complex (ORC) in an open conformation (2020) (0)
- Structure of human TUT7 catalytic module (CM) in complex with UMPNPP and U2 RNA (2017) (0)
- GAL6, YEAST BLEOMYCIN HYDROLASE DNA-BINDING PROTEASE (THIOL) (1995) (0)
- Symmetric reconstruction of human norovirus GII.2 Snow Mountain Virus Strain VLP in T=3 symmetry (2019) (0)
- A shape-shifting nuclease unravels structured RNA (2021) (0)
- A Kinked Model of aDNA Tridecamer with an Unpaired Adenosine: Energy Minimization and X-ray Structural Studies (1988) (0)
- Structure of mouse Dis3L2 in complex with oligoU RNA substrate (2014) (0)
- Asymmetric focused reconstruction of human norovirus GI.1 Norwalk strain VLP asymmetric unit in T=3 symmetry (2019) (0)
- The GAL regulon in S. cerevisiae: the Gal3p/Gal80p interaction (2011) (0)
- Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a human MenBeta minihelix ending in CCACC and AMPcPP (2015) (0)
- Abstract 5156: Upstream activation of PTEN. (2013) (0)
- OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage (2022) (0)
- ORC-O2WH: Human Origin Recognition Complex (ORC) with dynamic/unresolved ORC1 AAA+ domain (2020) (0)
- The Origin Recognition Complex: where it all begins (2018) (0)
- Chromodomain of Chp1 in complex with Histone H3K9me3 peptide (2009) (0)
- Crystal structure of Zucchini from mouse (mZuc / PLD6 / MitoPLD) (2012) (0)
- Crystal structure of the super-repressor mutant of Gal80p from Saccharomyces cerevisiae; Gal80(S0)-[G301R] (2008) (0)
- Crystal structure of EBA-175 Region II (RII) crystallized in the presence of (alpha)2,3-sialyllactose (2005) (0)
- The Structure of human Argonaute-1 in complex with the hook motif of human GW182 (2017) (0)
- GAL6 (YEAST BLEOMYCIN HYDROLASE) MUTANT C73A/DELTAK454 (1998) (0)
- CRYSTAL STRUCTURE OF THE P65 CRYSTAL FORM OF PHOTOACTIVE YELLOW PROTEIN (2000) (0)
- Symmetric reconstruction of human norovirus GII.4 Minerva strain VLP in T=4 symmetry (2019) (0)
- Harnessing insulin- and leptin-induced oxidation of PTP1B for therapeutic development (2018) (0)
- CRYSTAL STRUCTURE OF THE APAF-1 CARD (1999) (0)
- furiosus rubredoxin from the marine hyperthermophilic archaebacterium X-ray crystal structures of the oxidized and reduced forms of the data (0)
- Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a G70A arginyl-tRNA minihelix and CTP (2015) (0)
- Crystal structure of a ternary complex of the transcriptional repressor Gal80p (Gal80S0 [G301R]) and the acidic activation domain of Gal4p (aa 854-874) from Saccharomyces cerevisiae with NAD (2008) (0)
- Structure of human TUT7 catalytic module (CM) (2017) (0)
- Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a G70A arginyl-tRNA minihelix ending in CCACC and AMPcPP (2015) (0)
- DNA DECAMER WITH AN ENGINEERED CROSSLINK IN THE MINOR GROOVE (1999) (0)
- Crystal structure of the full-length human mitochondrial CCA-adding enzyme (2015) (0)
- Author response: Structure of the active form of human origin recognition complex and its ATPase motor module (2016) (0)
- CRYSTAL STRUCTURE OF THE P65 CRYSTAL FORM OF PHOTOACTIVE YELLOW PROTEIN G47S/G51S MUTANT (2002) (0)
- Asymmetric focused reconstruction of human norovirus GI.7 Houston strain VLP asymmetric unit in T=3 symmetry (2019) (0)
- Structure of Human Argonaute-1 let-7 complex (2013) (0)
- Crystal structure of H369A mutant of yeast bleomycin hydrolase (2007) (0)
- NSLS 2002 annual users' meeting (2002) (0)
- Modeling the Structure and Function of Argonaute in RNAi (2013) (0)
- Structure of Human Argonaute-1 bound to endogenous Sf9 RNA (2013) (0)
- Crystal structure of papillomavirus E1 hexameric helicase with ssDNA and MgADP (2006) (0)
- Measurement of in vivo RISC activity using an in vitro non-radioactive RISC assay (2009) (0)
- Crystal Structure of the DNA-binding domain of the human papillomavirus type 18 (HPV-18) replication initiation protein E1 (2003) (0)
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