Leendert Bosch
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Dutch biochemist
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Leendert Boschbiology Degrees
Biology
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Biochemistry
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Biology
Leendert Bosch's Degrees
- PhD Biochemistry University of Amsterdam
- Masters Chemistry University of Amsterdam
Why Is Leendert Bosch Influential?
(Suggest an Edit or Addition)According to Wikipedia, Leendert Bosch was a Dutch biochemist. He was a professor of biochemistry at Leiden University from 1964 to 1990. Bosch was born on 13 November 1924 in Appingedam. He obtained his title of Doctor at Delft University of Technology in 1955, with a dissertation titled "Biochemische en endocrinologische onderzoekingen van normaal en neoplastisch weefsel : de stofwisseling van oestrogeen producerende ovariumtumoren" . In 1961 Bosch was named lector of biochemistry in extraordinary service at Leiden University. In 1963 he became a regular lector, and in 1964 he was named professor.
Leendert Bosch's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A new principle of RNA folding based on pseudoknotting. (1985) (359)
- The tRNA-like structure at the 3' terminus of turnip yellow mosaic virus RNA. Differences and similarities with canonical tRNA. (1982) (176)
- The role of FIS in trans activation of stable RNA operons of E. coli. (1990) (167)
- Three‐dimensional models of the tRNA‐like 3′ termini of some plant viral RNAs. (1983) (139)
- FIS-dependent trans activation of stable RNA operons of Escherichia coli under various growth conditions (1992) (133)
- Five pseudoknots are present at the 204 nucleotides long 3' noncoding region of tobacco mosaic virus RNA. (1985) (128)
- RNA pseudoknots: Translational frameshifting and readthrough on viral RNAs (1990) (110)
- tRNA‐like structures (1991) (108)
- Prokaryotic elongation factor Tu is phosphorylated in vivo. (1993) (82)
- The elongation factor EF-Tu and its two encoding genes. (1983) (77)
- Mutants of the elongation factor EF‐Tu, a new class of nonsense suppressors. (1985) (75)
- The three‐dimensional folding of the tRNA‐like structure of tobacco mosaic virus RNA. A new building principle applied twice (1984) (73)
- In vitro translation of alfalfa mosaic virus RNA (1967) (64)
- Isolation and functional analysis of histidine-tagged elongation factor Tu. (1992) (62)
- The role of EF-Tu in the expression of tufA and tufB genes. (1983) (59)
- The structural and functional basis for the kirromycin resistance of mutant EF‐Tu species in Escherichia coli. (1994) (59)
- RNA pseudoknots: structure, detection, and prediction. (1989) (57)
- Methylation in vivo of elongation factor EF-Tu at lysine-56 decreases the rate of tRNA-dependent GTP hydrolysis. (1986) (55)
- Effects of the mutation glycine-222----aspartic acid on the functions of elongation factor Tu. (1987) (53)
- Mutants of Escherichia coli altered in both genes coding for the elongation factor Tu. (1978) (53)
- Properties of the tobacco mosaic virus intermediate length RNA-2 and its translation. (1983) (52)
- Cross-linking of tRNA at two different sites of the elongation factor Tu. (1984) (51)
- Three tuf-like genes in the kirromycin producer Streptomyces ramocissimus. (1994) (50)
- Structural studies on the coat protein of alfalfa mosaic virus. The complete primary structure. (1977) (50)
- tRNA-like structures. Structure, function and evolutionary significance. (1991) (48)
- A comparative study of the ribosomal RNA operons of Streptomyces coelicolor A3(2) and sequence analysis of rrnA. (1991) (48)
- Regulation of the expression of tufA and tufB, the two genes coding for the elongation factor EF‐Tu in escherichia coli (1982) (45)
- FIS-dependent trans-activation of tRNA and rRNA operons of Escherichia coli. (1990) (43)
- Translation of turnip yellow mosaic virus RNA in vitro: a closed and an open coat protein cistron. (1976) (42)
- Initiation factor-dependent binding of MS2 RNA to 30-S ribosomes and the recycling of IF-3. (1973) (41)
- Potential binding sites of the trans-activator FIS are present upstream of all rRNA operons and of many but not all tRNA operons. (1990) (41)
- Structural similarities among valine-accepting tRNA-like structures in tymoviral RNAs and elongator tRNAs (1987) (39)
- Structural studies on the coat protein of alfalfa-mosaic virus. (1972) (39)
- Isolation and characterization of a mocimycin resistant mutant of Escherichia coli with an altered elongation factor EF‐Tu (1977) (38)
- Specific alterations of the EF‐Tu polypeptide chain considered in the light of its three‐dimensional structure. (1984) (38)
- Translational frameshifts induced by mutant species of the polypeptide chain elongation factor Tu of Escherichia coli. (1989) (36)
- Interference of virginiamycin M with the initiation and the elongation of peptide chains in cell-free systems. (1974) (35)
- Studies on cytoplasmic ribonucleic acid from rat liver. I. Fractionation and function of soluble ribonucleic acid. (1960) (34)
- Zone-interference gel electrophoresis: a new method for studying weak protein-nucleic acid complexes under native equilibrium conditions. (1988) (29)
- Temperature dependent chemical and enzymatic probing of the tRNA-like structure of TYMV RNA. (1988) (29)
- Pulvomycin‐resistant mutants of E.coli elongation factor Tu. (1994) (29)
- Association products of native and derived ribosomal subunits of E. coli and their stability during centrifugation (1971) (28)
- Inactivation of the fis gene leads to reduced growth rate. (1992) (28)
- An initiation factor causing dissociation of E. coli ribosomes (1970) (28)
- The tRNA-tufB operon transcription termination and processing upstream from tufB. (1987) (27)
- STIMULATION AND INHIBITION OF POLYPEPTIDE SYNTHESIS BY STREPTOMYCIN IN RIBOSOMAL SYSTEMS OF ESCHERICHIA COLI, PROGRAMMED WITH VARIOUS MESSENGERS. (1965) (27)
- Antibiotic resistance mechanisms of mutant EF-Tu species in Escherichia coli. (1995) (27)
- A second tRNA binding site on elongation factor Tu is induced while the factor is bound to the ribosome. (1985) (27)
- tRNA-like properties of tobacco rattle virus RNA. (1987) (27)
- Molecular properties of two mutant species of the elongation factor Tu. (2005) (26)
- Elongation factor Tu isolated from Escherichia coli mutants altered in TufA and tufB. (1980) (26)
- Dissociation of 70 S E. coli ribosomes induced by a ribosomal factor (DF). Electrophoretic studies of the ribosomal particles (1970) (26)
- The involvement of a complex between formylmethionyl-tRNA and initiation factor IF-2 in prokaryotic initiation. (1977) (26)
- Immunocytochemical localization of the elongation factor Tu in E. coli cells (1984) (25)
- Binding of the initiation factor IF-3 to Escherichia coli ribosomes and MS2 RNA. (1973) (25)
- High-resolution proton magnetic resonance study of the secondary structure of the 3'-terminal 49-nucleotide fragment of 16S rRNA from Escherichia coli. (1977) (25)
- The association of ribosomal subunits of Escherichia coli. 1. Two types of association products differing in their apparent sedimentation coefficient. (1973) (24)
- Specific in situ cleavage of 16S ribosomal RNA of Escherichia coli interferes with the function of initiation factor IF-1. (1976) (24)
- tuf gene dosage effects on the intracellular concentration of EF-TuB. (1983) (24)
- The association of ribosomal subunits of Escherichia coli. 2. Two types of association products differing in sensitivity to hydrostatic pressure generated during centrifugation. (1973) (24)
- Translational studies with turnip yellow mosaic virus RNAs isolated from major and minor virus particles. (1979) (24)
- A mutant elongation factor Tu which does not immobilize the ribosome upon binding of kirromycin. (2005) (23)
- The elongation factor EF-Tu from E. coli binds to the upstream activator region of the tRNA-tufB operon. (1988) (23)
- In Vivo and in Vitro Translation of the RNAS of Alfalfa Mosaic Virus (1977) (23)
- The primary structure of the coat protein of alfalfa mosaic virus strain VRU. A hypothesis on the occurrence of two conformations in the assembly of the protein shell. (1979) (22)
- The Guanine — Nucleotide Binding Proteins (1989) (22)
- Transcription of the tRNA-tufB operon of Escherichia coli: activation, termination and antitermination. (1987) (22)
- Different species of 70S ribosomes of Escherichia coli and their dissociation into subunits. (1970) (21)
- Mutational analysis of the pseudoknot in the tRNA-like structure of turnip yellow mosaic virus RNA. Aminoacylation efficiency and RNA pseudoknot stability. (1992) (21)
- Studies on the ribosomal initiation factor F3. Multiplicity of F3 and DF activities (1971) (21)
- In situ breakage of turnip yellow mosaic virus RNA and in situ aggregation of the fragments. (1967) (20)
- Characterization of regular polymerization products of elongation factor EF-Tu from Escherichia coli by electron microscopy and image processing. (1981) (20)
- Properties of turnip yellow mosaic virus in cesium chloride solutions: the formation of high-density components. (1982) (20)
- The occurrence of the coat protein messenger RNA in the minor components of turnip yellow mosaic virus (1977) (19)
- Messenger ribonucleoprotein complexes in human KB cells infected with adenovirus type 5 contain tightly bound viral-coded '100K' proteins. (1979) (19)
- Transcription analysis of the Streptomyces coelicolor A3(2) rrnA operon. (1994) (19)
- THE READ-OUT OF TURNIP YELLOW MOSAIC VIRUS RIBONUCLEIC ACID AS A POLYCISTRONIC MESSENGER IN CELL-FREE SYSTEMS OF ESCHERICHIA COLI. (1965) (19)
- Cloning and sequencing of the tuf genes of Streptomyces coelicolor A3(2). (1994) (19)
- Kirromycin drastically reduces the affinity of Escherichia coli elongation factor Tu for aminoacyl-tRNA. (1991) (19)
- The elongation factor Tu.kirromycin complex has two binding sites for tRNA molecules. (1982) (19)
- The tuf3 gene of Streptomyces coelicolor A3(2) encodes an inessential elongation factor Tu that is apparently subject to positive stringent control. (1995) (18)
- Release factor binding to ribosome requires an intact 16 S rRNA 3' terminus. (1977) (18)
- Recycling of the initiation factor IF‐3 on 30 S ribosomal subunits of E. coli (1973) (18)
- Allosteric changes of the guanine nucleotide site of elongation factor EF‐Tu (1982) (18)
- Studies on cytoplasmic ribonucleic acid from rat liver. V. Cofactor requirements for the metabolic interaction between soluble and microsomal ribonucleic acid. (1962) (17)
- The effect of puromycin on nucleotide and amino acid transfer from soluble ribonucleic acid to the microsomes. (1961) (17)
- The release of enzymes from ascites-tumour cells into the extracellular medium. (1958) (16)
- The mechanism of trans-activation of the Escherichia coli operon thrU(tufB) by the protein FIS. A model. (1992) (16)
- Initiation factor IF-3 and the binary complex between initiation factor IF-2 and formylmethionyl-tRNA are mutually exclusive on the 30-S ribosomal subunit. (1978) (16)
- Metabolic inter-relationships between soluble and microsomal RNA in ratliver cytoplasm. (1959) (16)
- GTPase center of elongation factor Tu is activated by occupation of the second tRNA binding site. (1986) (15)
- The 3′‐terminus of 16 S ribosomal RNA of Escherichia coli. Isolation and purification of the terminal 49‐nucleotide fragment at a milligram scale (1976) (15)
- Substitution of Arg230 and Arg233 in Escherichia coli elongation factor Tu strongly enhances its pulvomycin resistance. (1995) (15)
- Transfer of plasmid-borne tuf mutations to the chromosome as a genetic tool for studying the functioning of EF-TuA and EF-TuB in the E. coli cell. (1987) (15)
- Control of the tRNA-tufB operon in Escherichia coli. 1. rRNA gene dosage effects and growth-rate-dependent regulation. (1988) (14)
- Electrophoretic separation of Escherichia coli ribosomal particles on polyacrylamide gels. (1973) (14)
- FIS-induced bending of a region upstream of the promoter activates transcription of the E coli thrU(tufB) operon. (1991) (14)
- The proteins associated with mRNA from uninfected and adenovirus type 5‐infected KB cells (1975) (14)
- Biochemical and biophysical analysis of pseudoknot-containing RNA fragments. Melting studies and NMR spectroscopy. (1989) (14)
- Ribonucleic acid toluidine blue complexes studied by gel electrophoresis and spectrophotometry (1969) (14)
- Mapping of genes involved in macromolecular synthesis on the chromosome of Streptomyces coelicolor A3(2) (1995) (14)
- Hydrodynamic properties of RNA: effect of multivalent cations on the sedimentation behavior of turnip yellow mosaic virus RNA (1985) (13)
- Studies on the elongation factor Tu from Streptomyces aureofaciens producing tetracycline. (1981) (13)
- Binding of labeled initiation factor IF-1 to ribosomal particles and the relationship to the mode of IF-1 action in ribosome dissociation. (1978) (13)
- In situ breakage of turnip yellow mosaic virus RNA and in situ aggregation of the fragments. Analysis of successive stages. (1969) (13)
- Chain initiation during polypeptide synthesis in cell-free bacterial systems programmed with plant viral messengers. 3. A comparison with the phage RNA-directed system. (1969) (13)
- Aminoacylation of 3' terminal tRNA-like fragments of turnip yellow mosaic virus RNA: the influence of 5' nonviral sequences. (1990) (13)
- Novel RNA interactions with the elongation factor EF-Tu: consequences for protein synthesis and tuf gene expression (1985) (12)
- Consequences of a specific cleavage in situ of 16-S ribosomal RNA for polypeptide chain elongation. (1978) (12)
- Studies on cytoplasmic ribonucleic acid from rat liver. III. Further characterizations of soluble and microsomal ribonucleic acid subfractions as isolated on modified cellulose ion exchangers. (1961) (12)
- An Escherichia coli mutant with an altered elongation factor Tu. (1974) (12)
- Nonstructural alfalfa mosaic virus RNA-coded proteins present in tobacco leaf tissue. (1984) (11)
- Zone-electrophoretic studies on soluble RNA from rat-liver cytoplasm. (1959) (11)
- Requirements and tentative mechanism for the interaction between soluble and microsomal ribonucleic acid in rat liver. (1962) (11)
- Translation of MS2 RNA in vitro in the absence of initiation factor IF-3. (1978) (11)
- Translational activities of EF-Tu [G222D] which cannot be reconciled with the classical scheme of the polypeptide chain elongation cycle. (1996) (11)
- STIMULATION AND INHIBITION OF POLYPEPTIDE SYNTHESIS BY STREPTOMYCIN. (1964) (11)
- Studies on cytoplasmic ribonucleic acid from rat liver. VI. Tentative mechanism of the metabolic interaction between soluble and microsomal ribonucleic acid. (1962) (10)
- Isolation and stability of ternary complexes of elongation factor Tu, GTP and aminoacyl-tRNA. (1991) (10)
- Initiation of polypeptide synthesis with various NH2-blocked aminoacyl-tRNAs under the direction of alfalfa mosaic virus RNA 4. (1977) (10)
- Mutant species of EF‐Tu, altered at position 375, exhibit a reduced affinity for aminoacylated transfer‐RNAs (1985) (10)
- Studies on cytoplasmic ribonucleic acid from rat liver: IV. Distribution of odd nucleotides in ribonucleic acid fractions (1962) (9)
- Differential inhibition of the in vivo synthesis of adenovirus type 5-specific ribonucleic acids by cordycepin. (1975) (9)
- Control of the tRNA-tufB operon in Escherichia coli. 2. Mechanisms of the feedback inhibition of tufB expression studied in vivo and in vitro. (1988) (9)
- The primary structure of the coat protein of alfalfa mosaic virus (strain 425). (1976) (9)
- Interaction between plant viral RNA and Escherichia coli ribosomes. (1968) (8)
- The binding of aminoacyl-tRNA to complexes of Escherichia coli ribosomes and plant viral RNA. (1968) (8)
- The formation of fast-sedimenting turnip yellow mosaic virus RNA: structural rearrangement inside the capsid. (1977) (8)
- Modified Cellulose Ion Exchangers and their Use in Ribonucleic Acid Fractionation (1961) (8)
- Translation by Escherichia coli ribosomes of alfalfa mosaic virus RNA 4 can be initiated at two sites on the monocistronic message. (1979) (8)
- DEGRADATION OF VIRAL MESSENGER RNA BY ENZYMES FROM ESCHERICHIA COLI. (1965) (7)
- Structural studies on the coat protein of alfalfa mosaic virus. Isolation and characterization of the tryptic peptides and the alignment of the cyanogen-bromide fragments. (1975) (7)
- Factor requirement of formylmethionyl‐tRNA binding to E. coli ribosomes programmed with a plant viral RNA or a phage RNA (1969) (7)
- The use of rubber columns in the isolation of oestriol from pregnancy urine. (1953) (7)
- Elongation factors in protein synthesis. (1993) (7)
- Q beta replicase containing wild type and mutant tufA and tufB gene. (1980) (7)
- A growth-defective kirromycin-resistant EF-Tu Escherichia coli mutant and a spontaneously evolved suppression of the defect. (1995) (6)
- The 50-S ribosomal subunit inhibits functional interaction between the 30-S subunit and phage RNA. (1978) (6)
- EFFECTS OF STREPTOMYCIN ON THE TRANSLATION OF TURNIP YELLOW MOSAIC VIRUS RNA IN VITRO. (1965) (6)
- Chain initiation during polypeptide synthesis in cell-free bacterial systems programmed with plant viral messengers. II. The role of N-formylmethionine. (1968) (6)
- Chain initiation during polypeptide synthesis in a cell-free bacterial system programmed with plant viral messengers. I. Dependence on formylation and ribosomal factors. (1968) (6)
- Thermosensitive Mutants of Escherichia coli Unable to Propagate RNA Phage at 42 "C and Altered in Protein Synthesis (1974) (5)
- Studies on cytoplasmic ribonucleic acid from rat liver: VII. The association between ribosomes and transfer ribonucleic acid (1965) (5)
- Novel Functions of EF-Tu during Polypeptide Synthesis and tuf Gene Expression (1986) (5)
- Initiation of plant viral RNA-directed polypeptide synthesis with N-acetylphenylalanyl-tRNA. (1967) (5)
- TURNIP YELLOW MOSAIC VIRUS RNA: A POLYCISTRONIC MESSENGER FOR POLYPEPTIDE SYNTHESIS BY ESCHERICHIA COLI RIBOSOMES. (1964) (5)
- A technique for targeted mutagenesis of the EF-Tu chromosomal gene by M13-mediated gene replacement (1993) (4)
- Pseudoknots in RNA: A Novel Folding Principle (1986) (4)
- Improved Cutting Device for Starch Block Electrophoresis (1959) (4)
- Killing of 32 P-labelled single-stranded-RNA bacteriophage MS2. (1973) (4)
- Interaction between rat-liver ribosomes and soluble ribonucleic acid. (1963) (3)
- The influence of tRNA located at the P-site on the turnover of EF-Tu.GTP on ribosomes. (1991) (3)
- A revised bacterial polypeptide chain elongation cycle with a stepwise increase in restriction of unwanted ternary complexes by the ribosome. (1996) (3)
- The Elongation Factor EF-Tu FROM E. Coli Activates The tRNA-Tufb Operon in Trans by Binding To A Cis-Acting Region Upstream of The Promoter (1989) (3)
- RIBONUCLEOTIDE AND AMINO ACID TRANSFER FROM SOLUBLE RNA TO MICROSOMES FROM NORMAL AND NEOPLASTIC TISSUE. (1964) (3)
- Chain initiation during polypeptide synthesis in cell-free bacterial systems programmed with a plant viral messenger. Initiation with N-acetylated aminoacyl-tRNAs on adjacent codons. (1971) (3)
- Thermal stability of turnip yellow mosaic virus RNA: effect of pH and multivalent cations on RNA deaggregation and degradation. (1991) (3)
- Age dependence of cowpea protoplasts for uptake of spermidine and infectibility by alfalfa mosaic virus (1983) (3)
- Chain initiation during polypeptide synthesis in cell-free bacterial systems programmed with a plant viral messenger. The formation of N-acetylphenylalanylisoleucyl-tRNA on the messenger-ribosome complex. (1971) (3)
- Control of the tRNA-tufB operon in Escherichia coli. 3. Feedback inhibition of tufB expression by an EF-Tu with a deletion in the guanine-nucleotide-binding domain. (1988) (2)
- Formation of a preribosomal binary complex consisting of fMet-tRNA and IF-2 and its interaction with the ribosome. (1979) (2)
- Consequences of a specific cleavage in situ of 16-S ribosomal RNA for polypeptide chain initiation. (1978) (2)
- Studies on cytoplasmic ribonucleic acid from rat liver. II. Fractionation and function of microsomal ribonucleic acid. (1960) (1)
- Effects of Kirromycin on the Elongation Factor EF-Tu and its Interactions with GDP or GTP and tRNA. The Application of zone-Interference Gel Electrophoresis, a New Method for the Analysis of Weak Complexes (1989) (1)
- Studies on cytoplasmic ribonucleic acid from rat liver. IV. Distribution of odd nucleotides in ribonucleic acid fractions. (1962) (1)
- Do cotranscripts of viral and cellular DNA exist in KB cells lytically infected with adenovirus 5? A hybridization study. (1978) (1)
- REGULATION OF THE EXPRESSION OF tufA AND tufB, THE TWO GENES ENCODING THE ELONGATION FACTOR EF-Tu IN E. COLI (1982) (1)
- Elfamycin-resistant variant (1991) (0)
- Thermosensitive mutants of Escherichia coli unable to propagate RNA phage at 42 degrees C and altered in protein synthesis. (1974) (0)
- THE FUNCTIONING OF A MUTANT SPECIES OF THE ELONGATION FACTOR EF-Tu FROM E. COLI (1981) (0)
- Transcription of the tRNA-fti/B operon of Escherichia coli: activation, termination and antiterminatlon (1987) (0)
- The Guanine - Nucleotide Binding Proteins: Common Structural And Functional Properties (2013) (0)
- Three-dimensional image reconstruction of helical aggregates of trypsin modified elongation factor EF-Tu from Escherichia coli: comparison with the reconstructed image of intact EF-Tu. (1986) (0)
- Table of Contents (1990) (0)
- The tRNA-Iike Structure of the 3 End of Some Plant Viral RNAs (1988) (0)
- Three-dimensional image reconstruction of helical aggregates of trypsin modified elongation factor EF-Tu from Escherichia coli (1986) (0)
- EXPRESSION OF tufA AND tufB IN E. COLI MUTANTS WITH AN ALTERED ELONGATION FACTOR EF-Tu (1981) (0)
- Selection and analysis of viral RNA from rat embryo cells transformed by adenovirus 2 (cell line 8617): an investigation on cotranscription of viral and cellular DNA. (1980) (0)
- Preliminary noteRequirements and tentative mechanism for the interaction between soluble and microsomal ribonucleic acid in rat liver (1962) (0)
- Fis-Dependent Trans-Activation of Stable RNA Operons and Bacterial Growth (1993) (0)
- The transfer rna like structure of the 3' end of some plant viral rna (1988) (0)
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