Lei Stanley Qi
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Lei Stanley Qiengineering Degrees
Engineering
#3647
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#4755
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Bioengineering
#41
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#43
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Lei Stanley Qibiology Degrees
Biology
#6935
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#9754
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Evolutionary Biology
#337
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#361
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Molecular Biology
#2375
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#2412
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Engineering Biology
Lei Stanley Qi's Degrees
- PhD Bioengineering Stanford University
- Bachelors Bioengineering University of California, Berkeley
Why Is Lei Stanley Qi Influential?
(Suggest an Edit or Addition)According to Wikipedia, Lei "Stanley" Qi is an associate professor in the department of bioengineering, and the department of chemical and systems biology at Stanford University. Qi led the development of the first catalytically dead Cas9 lacking endonuclease activity , which is the basis for CRISPR interference . His laboratory subsequently developed CRISPR-Genome Organization .
Lei Stanley Qi's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression (2013) (3736)
- CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes (2013) (2839)
- Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation (2014) (1951)
- A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging (2014) (1089)
- Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System (2013) (1085)
- CRISPR interference (CRISPRi) for sequence-specific control of gene expression (2013) (852)
- CRISPR/Cas9 in Genome Editing and Beyond. (2016) (799)
- Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds (2015) (783)
- Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System (2014) (773)
- Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation (2015) (670)
- A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria (2016) (479)
- CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs. (2016) (377)
- Small molecules enhance CRISPR genome editing in pluripotent stem cells. (2015) (373)
- Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza (2020) (288)
- Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions (2017) (270)
- Versatile RNA-sensing transcriptional regulators for engineering genetic networks (2011) (232)
- Complex transcriptional modulation with orthogonal and inducible dCas9 regulators (2016) (228)
- RNA processing enables predictable programming of gene expression (2012) (195)
- A CRISPR-dCas Toolbox for Genetic Engineering and Synthetic Biology. (2019) (184)
- The New State of the Art: Cas9 for Gene Activation and Repression (2015) (176)
- Rationally designed families of orthogonal RNA regulators of translation. (2012) (167)
- CRISPR-ERA: a comprehensive design tool for CRISPR-mediated gene editing, repression and activation (2015) (150)
- CRISPR-Mediated Programmable 3D Genome Positioning and Nuclear Organization (2018) (142)
- CRISPR-mediated live imaging of genome editing and transcription (2019) (141)
- YAP Induces Human Naive Pluripotency (2016) (138)
- Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells (2020) (136)
- Genetic interaction mapping in mammalian cells using CRISPR interference (2017) (132)
- CRISPR Activation Screens Systematically Identify Factors that Drive Neuronal Fate and Reprogramming. (2018) (125)
- CRISPR technologies for precise epigenome editing (2021) (123)
- CRISPR-Based Chromatin Remodeling of the Endogenous Oct4 or Sox2 Locus Enables Reprogramming to Pluripotency. (2018) (121)
- Toward scalable parts families for predictable design of biological circuits. (2008) (110)
- Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells (2019) (106)
- YAP-independent mechanotransduction drives breast cancer progression (2018) (104)
- DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells (2018) (100)
- Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing. (2021) (90)
- Mechanistic insights into metal ion activation and operator recognition by the ferric uptake regulator (2015) (90)
- A Single-Chain Photoswitchable CRISPR-Cas9 Architecture for Light-Inducible Gene Editing and Transcription (2017) (87)
- Engineering naturally occurring trans-acting non-coding RNAs to sense molecular signals (2012) (86)
- A versatile framework for microbial engineering using synthetic non-coding RNAs (2014) (83)
- CRISPR/Cas9 for Human Genome Engineering and Disease Research. (2016) (77)
- Applications of CRISPR Genome Engineering in Cell Biology. (2016) (72)
- An adaptor from translational to transcriptional control enables predictable assembly of complex regulation (2012) (71)
- Plant-Plant-Microbe Mechanisms Involved in Soil-Borne Disease Suppression on a Maize and Pepper Intercropping System (2014) (69)
- Bacterial CRISPR: accomplishments and prospects. (2015) (68)
- Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system (2017) (68)
- Transcription factor competition allows embryonic stem cells to distinguish authentic signals from noise. (2015) (66)
- Multiplexed Dynamic Imaging of Genomic Loci by Combined CRISPR Imaging and DNA Sequential FISH (2017) (65)
- Faculty of 1000 evaluation for Biology and applications of CRISPR systems: harnessing nature's toolbox for genome engineering. (2017) (63)
- Genetic and epigenetic control of gene expression by CRISPR–Cas systems (2017) (61)
- High-content CRISPR screening (2022) (56)
- Specific Gene Repression by CRISPRi System Transferred through Bacterial Conjugation (2014) (51)
- Targeted Transcriptional Repression in Bacteria Using CRISPR Interference (CRISPRi). (2015) (50)
- Global mapping transcriptional start sites revealed both transcriptional and post-transcriptional regulation of cold adaptation in the methanogenic archaeon Methanolobus psychrophilus (2015) (47)
- FeoB2 Functions in Magnetosome Formation and Oxidative Stress Protection in Magnetospirillum gryphiswaldense Strain MSR-1 (2012) (40)
- Multiple Input Sensing and Signal Integration Using a Split Cas12a System. (2020) (39)
- Genome-wide mapping of spontaneous genetic alterations in diploid yeast cells (2020) (37)
- Fibrinogen Alpha Chain Knockout Promotes Tumor Growth and Metastasis through Integrin–AKT Signaling Pathway in Lung Cancer (2020) (37)
- Low-frequency ultrasound-mediated cytokine transfection enhances T cell recruitment at local and distant tumor sites (2020) (36)
- Regulation of transcription by unnatural amino acids (2011) (35)
- A benchmark of algorithms for the analysis of pooled CRISPR screens (2020) (35)
- Fur in Magnetospirillum gryphiswaldense Influences Magnetosomes Formation and Directly Regulates the Genes Involved in Iron and Oxygen Metabolism (2012) (34)
- Reversible Disruption of Specific Transcription Factor-DNA Interactions Using CRISPR/Cas9. (2019) (28)
- CRISPhieRmix: a hierarchical mixture model for CRISPR pooled screens (2018) (27)
- Development of CRISPR as a prophylactic strategy to combat novel coronavirus and influenza (2020) (27)
- Double Emulsion Picoreactors for High-Throughput Single-Cell Encapsulation and Phenotyping via FACS (2020) (24)
- Genomic structural variation contributes to phenotypic change of industrial bioethanol yeast Saccharomyces cerevisiae. (2016) (23)
- Characterization of an Archaeal Two-Component System That Regulates Methanogenesis in Methanosaeta harundinacea (2014) (23)
- Nested epistasis enhancer networks for robust genome regulation (2022) (23)
- Repurposing CRISPR System for Transcriptional Activation. (2017) (20)
- CRISPR Technology for Genome Activation and Repression in Mammalian Cells. (2016) (20)
- Deletion of JJJ1 improves acetic acid tolerance and bioethanol fermentation performance of Saccharomyces cerevisiae strains (2016) (19)
- A comprehensive analysis and resource to use CRISPR-Cas13 for broad-spectrum targeting of RNA viruses (2021) (19)
- Engineering 3D genome organization (2021) (19)
- When genome editing goes off-target (2019) (18)
- Multiplexed genome regulation in vivo with hyper-efficient Cas12a (2022) (17)
- Genome-wide mRNA processing in methanogenic archaea reveals post-transcriptional regulation of ribosomal protein synthesis (2017) (16)
- The use of new CRISPR tools in cardiovascular research and medicine (2022) (16)
- Analysis of APOBEC-induced mutations in yeast strains with low levels of replicative DNA polymerases (2020) (16)
- CRISPR-based genome editing in primary human pancreatic islet cells (2021) (16)
- Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression (2021) (15)
- Conserved TRAM Domain Functions as an Archaeal Cold Shock Protein via RNA Chaperone Activity (2017) (15)
- The conserved ribonuclease aCPSF1 triggers genome-wide transcription termination of Archaea via a 3′-end cleavage mode (2020) (14)
- Genome-wide analysis of genomic alterations induced by oxidative DNA damage in yeast (2019) (14)
- Therapeutic genome editing in cardiovascular diseases. (2020) (14)
- Systematic genome-wide querying of coding and non-coding functional elements in E. coli using CRISPRi (2020) (12)
- Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitro (2022) (11)
- An Introduction to CRISPR Technology for Genome Activation and Repression in Mammalian Cells. (2016) (10)
- Comprehensive analysis of the pre-ribosomal RNA maturation pathway in a methanoarchaeon exposes the conserved circularization and linearization mode in archaea (2020) (10)
- Enhanced Cas12a multi-gene regulation using a CRISPR array separator (2021) (10)
- The archaeal RNA chaperone TRAM0076 shapes the transcriptome and optimizes the growth of Methanococcus maripaludis (2019) (9)
- Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes (2022) (9)
- Lentiviral delivery of combinatorial CAR/CRISPRi circuit into human primary T cells is enhanced by TBK1/IKKɛ complex inhibitor BX795 (2020) (9)
- Identification of cell context-dependent YAP-associated proteins reveals β1 and β4 integrin mediate YAP translocation independently of cell spreading (2019) (9)
- Single-cell transcriptomic profiling reveals distinct mechanical responses between normal and diseased tendon progenitor cells (2021) (9)
- Hydrogen peroxide, a potent inducer of global genomic instability (2019) (8)
- Interrogation of the dynamic properties of higher-order heterochromatin using CRISPR-dCas9. (2021) (8)
- Identification of Novel Regulatory Genes in APAP Induced Hepatocyte Toxicity by a Genome-Wide CRISPR-Cas9 Screen (2019) (7)
- Durable CRISPR-Based Epigenetic Silencing (2021) (7)
- Contextual reprogramming of CAR-T cells for treatment of HER2+ cancers (2020) (7)
- CRISPRi/a Screening with Human iPSCs. (2021) (7)
- Advances in CRISPR therapeutics (2022) (6)
- Dual CRISPR interference and activation for targeted reactivation of X-linked endogenous FOXP3 in human breast cancer cells (2022) (6)
- Genetic characterization and modification of a bioethanol-producing yeast strain (2018) (6)
- Multi-color super-resolution imaging to study human coronavirus RNA during cellular infection (2021) (5)
- The Archaeal Small Heat Shock Protein Hsp17.6 Protects Proteins from Oxidative Inactivation (2021) (5)
- Scalable Biological Signal Recording in Mammalian Cells Using Cas12a Base Editors (2022) (5)
- Global Analysis of Furfural-Induced Genomic Instability Using a Yeast Model (2019) (5)
- Multi-color super-resolution imaging to study human coronavirus RNA during cellular infection (2022) (5)
- Regenerating Urethral Striated Muscle by CRISPRi/dCas9-KRAB-Mediated Myostatin Silencing for Obesity-Associated Stress Urinary Incontinence. (2020) (5)
- Evolution at the Cutting Edge: CRISPR-Mediated Directed Evolution. (2018) (4)
- Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells (2020) (4)
- Computational Methods for Analysis of Large-Scale CRISPR Screens (2020) (4)
- Resource Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression (2013) (4)
- Biodesign Research to Advance the Principles and Applications of Biosystems Design (2019) (4)
- Interrogation of the Dynamic Properties of Higher-Order Heterochromatin Using CRISPR/dCas9 (2021) (4)
- Using CRISPR-ERA Webserver for sgRNA Design. (2017) (3)
- Methods and compositions for RNA-directed target DNA modification and for RNA-directed transcription modulation (2013) (3)
- CRISPR-mediated Synergistic Epigenetic and Transcriptional Control. (2022) (3)
- Site-Programmable Transposition: Shifting the Paradigm for CRISPR-Cas Systems. (2019) (3)
- aCPSF1 controlled archaeal transcription termination: a prototypical eukaryotic model (2019) (3)
- Resource A Comprehensive , CRISPR-based Functional Analysis of Essential Genes in Bacteria Graphical Abstract Highlights (2)
- Reversible inhibition of specific transcription factor-DNA interactions using CRISPR (2018) (2)
- Post-transcriptional regulation is involved in the cold active methanol-based methanogenic pathway of a psychrophilic methanogen. (2021) (2)
- Mapping chromosomal instability induced by small-molecular therapeutics in a yeast model (2019) (2)
- Abstract 185: p300 and STAT3 drive YAP-independent mechanotransduction during breast cancer invasion (2018) (1)
- SARS-CoV-2 escapes direct NK cell killing through Nsp1-mediated downregulation of ligands for NKG2D (2022) (1)
- [Application of genome engineering in medical synthetic biology]. (2017) (1)
- Temporal-Spatial Visualization of Endogenous Chromosome Rearrangements in Living Cells (2019) (1)
- A benchmark of algorithms for the analysis of pooled CRISPR screens (2020) (1)
- CRISPhieRmix: a hierarchical mixture model for CRISPR pooled screens (2018) (1)
- Contextual reprogramming of CAR-T cells for treatment of HER2+ cancers (2021) (1)
- Identification of Novel Regulatory Genes in APAP Induced Hepatocyte Toxicity by a Genome-Wide CRISPR-Cas9 Screen (2019) (1)
- Shuffling the yeast genome using CRISPR/Cas9-generated DSBs that target the transposable Ty1 elements (2023) (1)
- Hormone sensitive lipase ablation promotes bone regeneration. (2022) (1)
- Multiplexed dynamic imaging of genomic loci in single cells by combined CRISPR imaging and DNA sequential FISH (2017) (1)
- Abstract LB026: Nanoscale, antigen-dependent, reversible IL-12 secretion by CAR T cells for cancer treatment (2021) (1)
- Multiplexed genome regulation in vivo with hyper-efficient Cas12a (2022) (0)
- Methods and compositions for modifying target DNA directed RNA and modulation of transcription directed RNA (2013) (0)
- Faculty Opinions recommendation of An updated evolutionary classification of CRISPR-Cas systems. (2017) (0)
- Mandegar et al - Supplemental (2016) (0)
- CRFTSZ2 PROTEIN OF CHLOROPLAST INFLUENCES THE MORPHOLOGICAL CHANGES IN E.COLI (2005) (0)
- Cas9-Mediated Knockout of Ndrg2 Enhances the Regenerative Potential of Dendritic Cells for Wound Healing (2022) (0)
- Faculty Opinions recommendation of Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems. (2017) (0)
- A CRISPR – dCas Engineering and (2018) (0)
- Abstract B075: Conversion of extracellular signals to programmable genome manipulation via CRISPRouter (2016) (0)
- Faculty Opinions recommendation of Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions. (2017) (0)
- Enhanced Myogenesis by Silencing Myostatin with Nonviral Delivery of dCas9 Ribonucleoprotein Complex. (2022) (0)
- Strategies for study on directed evolution of enzyme (2005) (0)
- Lentiviral delivery of combinatorial CAR/CRISPRi circuit into human primary T cells is enhanced by TBK1/IKKɛ complex inhibitor BX795 (2020) (0)
- Genetic characterization and modification of a bioethanol-producing yeast strain (2018) (0)
- Targeted Reactivation of X-linked Endogenous FOXP3 Gene from X-chromosome Inactivation in Human Female Breast Cancer Cells (2021) (0)
- Resource CRISPR-Mediated Programmable 3 D Genome Positioning and Nuclear Organization Graphical Abstract Highlights (2018) (0)
- Faculty of 1000 evaluation for Diversity and evolution of class 2 CRISPR-Cas systems. (2017) (0)
- Methanogenesis at High Latitudes (2019) (0)
- Supporting Information Plasmids , Parts , and Strains (2015) (0)
- Scalable Genetic System Design Using Synthetic RNA Regulators (2012) (0)
- Deletion of JJJ1 improves acetic acid tolerance and bioethanol fermentation performance of Saccharomyces cerevisiae strains (2016) (0)
- YAP Induces Human Naive Pluripotency Graphical (2016) (0)
- The Conservative Function of Chloroplast Division Associated CrMinD Protein (2009) (0)
- Faculty Opinions recommendation of Functional annotation of native enhancers with a Cas9-histone demethylase fusion. (2017) (0)
- Reversible Disruption of S pecific Transcription Factor-DNA Interactions Using CRISPR / Cas 9 Graphical (2019) (0)
- DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells (2018) (0)
- Computation empowers CRISPR discovery and technology (2022) (0)
- CRISPR technologies for precise epigenome editing (2021) (0)
- Faculty of 1000 evaluation for The CRISPR-Cas immune system: biology, mechanisms and applications. (2017) (0)
- Programmable Drug Control of Receptor Valency Modulates the Potency of Cell Therapeutics (2023) (0)
- Hydrogen peroxide, a potent inducer of global genomic instability (2019) (0)
- Dual Activation of CD95/CXCR4 in HEK293T cells by Abscisic Acid- and Gibberellin-inducible dCas9s (Transient Transfection) (2016) (0)
- Nanoscale, antigen encounter-dependent, IL-12 delivery by CAR T cells plus PD-L1 blockade for cancer treatment (2023) (0)
- Faculty Opinions recommendation of Efficient generation of myostatin gene mutated rabbit by crispr/cas9. (2017) (0)
- Faculty Opinions recommendation of Multiplexable, locus-specific targeting of long RNAs with CRISPR-Display. (2017) (0)
- Corrigendum to "Hormone sensitive lipase ablation promotes bone regeneration" [Biochim. Biophys. Acta Mol. Basis Dis. Volume 1868, Issue 9, 1 September 2022, 166449]. (2022) (0)
- Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system (2017) (0)
- Origin, Regulation, and Fitness Effect of Chromosomal Rearrangements in the Yeast Saccharomyces cerevisiae (2021) (0)
- Multicolor super-resolution imaging to study human coronavirus RNA during cellular infection (2023) (0)
- Mapping chromosomal instability induced by small-molecular therapeutics in a yeast model (2019) (0)
- 765 Contextual secretion of nanoscale interleukin (IL)-12 by CAR T cells for the treatment of cancer (2020) (0)
- Stable expression of large transgenes via the knock-in of an integrase-deficient lentivirus. (2023) (0)
- Reversing the Central Dogma: RNA-guided control of DNA in epigenetics and genome editing. (2023) (0)
- What are the current bottlenecks in developing and applying CRISPR technologies? (2022) (0)
- Faculty Opinions recommendation of CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes. (2017) (0)
- EXPRESSION AND LOCATION OF CRFTSZ2 GENE FROM CHLAMYDOMONAS REINHARDTII IN E. coli (2004) (0)
- YAP-independent mechanotransduction drives breast cancer progression (2019) (0)
- Quantification of durable CRISPR-based gene silencing activity (2021) (0)
- Synthetic Biology for the Immunotherapy of Cancer (2021) (0)
- Principles of Systems Biology, No. 11. (2016) (0)
- Dual CRISPR interference and activation for targeted reactivation of X-linked endogenous FOXP3 in human breast cancer cells (2022) (0)
- Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells (2019) (0)
- Faculty Opinions recommendation of CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter. (2017) (0)
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What Schools Are Affiliated With Lei Stanley Qi?
Lei Stanley Qi is affiliated with the following schools:
