Leonard Erickson
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American oncologist
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Philosophy
Leonard Erickson's Degrees
- Doctorate Medicine Harvard University
Why Is Leonard Erickson Influential?
(Suggest an Edit or Addition)According to Wikipedia, Leonard C. Erickson was the Robert Wallace Miller Professor of Oncology at the Department of Pharmacology & Toxicology at Indiana University-Purdue University Indianapolis Cancer Center, and he also served as Deputy Director of the Indiana University Cancer Center.
Leonard Erickson's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Fractionation of DNA from mammalian cells by alkaline elution. (1976) (899)
- Protein-associated deoxyribonucleic acid strand breaks in L1210 cells treated with the deoxyribonucleic acid intercalating agents 4'-(9-acridinylamino) methanesulfon-m-anisidide and adriamycin. (1981) (382)
- DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells (1980) (321)
- Quantitation of Doxorubicin Uptake, Efflux, and Modulation of Multidrug Resistance (MDR) in MDR Human Cancer Cells (2008) (259)
- DNA crosslinking and cytotoxicity in normal and transformed human cells treated with antitumor nitrosoureas. (1980) (170)
- Comparison of the effects of hydrogen peroxide and x-ray irradiation on toxicity, mutation, and DNA damage/repair in mammalian cells (V-79). (1981) (168)
- A comparative study of the cytotoxicity and DNA-damaging effects of cis-(diammino)(1,1-cyclobutanedicarboxylato)-platinum(II) and cis-diamminedichloroplatinum(II) on L1210 cells. (1985) (108)
- Pretreatment of normal human fibroblasts and human colon carcinoma cells with MNNG allows chloroethylnitrosourea to produce DNA interstrand crosslinks not observed in cells treated with chloroethylnitrosourea alone. (1983) (91)
- A novel fluorometric oligonucleotide assay to measure O( 6)-methylguanine DNA methyltransferase, methylpurine DNA glycosylase, 8-oxoguanine DNA glycosylase and abasic endonuclease activities: DNA repair status in human breast carcinoma cells overexpressing methylpurine DNA glycosylase. (2001) (84)
- Pretreatment of human colon tumor cells with DNA methylating agents inhibits their ability to repair chloroethyl monoadducts. (1984) (76)
- Non-enzymatic DNA strand breaks induced in mammalian cells by fluorescent light. (1978) (70)
- Comparison of O-6-methylguanine DNA methyltransferase (MGMT) mRNA levels in Mer+ and Mer- human tumor cell lines containing the MGMT gene by the polymerase chain reaction technique. (1990) (70)
- DNA cross-linking and cytotoxicity in normal and transformed human cells treated in vitro with 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d] -1,2,3,5-tetrazin-4(3H)-one. (1984) (69)
- Direct correlation between methylation status and expression of the human O-6-methylguanine DNA methyltransferase gene. (1991) (65)
- Measurement of DNA damage in unlabeled mammalian cells analyzed by alkaline elution and a fluorometric DNA assay. (1980) (64)
- Inhibition of a specific DNA repair system and nitrosourea cytotoxicity in resistant human cancer cells. (1989) (62)
- DNA cross-linking and cytotoxicity induced by cis-diamminedichloroplatinum(II) in human normal and tumor cell lines. (1981) (61)
- 1-beta-D-arabinofuranosylcytosine and hydroxyurea production of cytotoxic synergy with cis-diamminedichloroplatinum(II) and modification of platinum-induced DNA interstrand cross-linking. (1989) (59)
- Differential cytotoxicity and DNA cross-linking in normal and transformed human fibroblasts treated with cis-diamminedichloroplatinum(II). (1981) (56)
- Strand breaks in DNA from normal and transformed human cells treated with 1,3-bis(2-chloroethyl)-1-nitrosourea. (1977) (56)
- DNA strand scission and cross-linking by diaziridinylbenzoquinone (diaziquone) in human cells and relation to cell killing. (1984) (55)
- Cytotoxicity and DNA cross-linking activity of 4-sulfidocyclophosphamides in mouse leukemia cells in vitro. (1980) (54)
- DNA cross-linking responses of human malignant glioma cell strains to chloroethylnitrosoureas, cisplatin, and diaziquone. (1987) (53)
- Comparative studies of DNA cross-linking and cytotoxicity in Burkitt's lymphoma cell lines treated with cis-diamminedichloroplatinum(II) and L-phenylalanine mustard. (1982) (53)
- In vivo selection of human hematopoietic cells in a xenograft model using combined pharmacologic and genetic manipulations. (2003) (51)
- Effects of dimethyl sulfoxide and thiourea upon intercalator-induced DNA single-strand breaks in mouse leukemia (L1210) cells. (1983) (50)
- Differential repair of 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea-induced DNA damage in two human colon tumor cell lines. (1978) (49)
- Transcription-terminating lesions induced by bifunctional alkylating agents in vitro. (1989) (49)
- Phase I study of streptozocin- and carmustine-sequenced administration in patients with advanced cancer. (1992) (48)
- Normal DNA strand rejoining and absence of DNA crosslinking in progeroid and aging human cells. (1976) (47)
- The role of mRNA stability and transcription in O6-methylguanine DNA methyltransferase (MGMT) expression in Mer+ human tumor cells. (1995) (46)
- Effects of the antitumor agent 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one on the DNA of mouse L1210 cells. (1984) (45)
- DNA adenine adducts induced by nitrogen mustards and their role in transcription termination in vitro. (1990) (43)
- Measurements of DNA damage in Chinese hamster cells treated with equitoxic and equimutagenic doses of nitrosoureas. (1978) (42)
- Interrelationships of protein and DNA syntheses during replication of mammalian cells (1985) (40)
- Prolonged depletion of O6-methylguanine DNA methyltransferase activity following exposure to O6-benzylguanine with or without streptozotocin enhances 1,3-bis(2-chloroethyl)-1-nitrosourea sensitivity in vitro. (1993) (40)
- Effects of streptozotocin/bis-chloroethylnitrosourea combination therapy on O6-methylguanine DNA methyltransferase activity and mRNA levels in HT-29 cells in vitro. (1991) (38)
- Chapter 6 – DNA CROSSLINKING AND THE ORIGIN OF SENSITIVITY TO CHLOROETHYLNITROSOUREAS (1981) (37)
- Dynamic Assessment of Mitoxantrone Resistance and Modulation of Multidrug Resistance by Valspodar (PSC833) in Multidrug Resistance Human Cancer Cells (2009) (37)
- Comparison of single- versus double-bolus treatments of O(6)-benzylguanine for depletion of O(6)-methylguanine DNA methyltransferase (MGMT) activity in vivo: development of a novel fluorometric oligonucleotide assay for measurement of MGMT activity. (2001) (36)
- Delayed repletion of O6-methylguanine-DNA methyltransferase resulting in failure to protect the human glioblastoma cell line SF767 from temozolomide-induced cytotoxicity. (2003) (36)
- Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea. (2003) (35)
- Synthesis and preliminary biological evaluation of radiolabeled O6-benzylguanine derivatives, new potential PET imaging agents for the DNA repair protein O6-alkylguanine-DNA alkyltransferase in breast cancer. (2003) (35)
- Dna chain growth during replication of asynchronous l1210 cells. Alkaline sedimentation studies. (1975) (35)
- Specific DNA repair mechanisms may protect some human tumor cells from DNA interstrand crosslinking by chloroethylnitrosoureas but not from crosslinking by other anti-tumor alkylating agents. (1985) (34)
- Prolonged Inhibition ofO6-Methylguanine DNA Methyltransferase in Human Tumor Cells by O6-Benzylguanine In Vitro and In Vivo (1999) (34)
- Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)methanesulfonate. (1988) (33)
- Differential inhibition of the rejoining of X-ray-induced DNA strand breaks in normal and transformed human fibroblasts treated with 1,3-bis(2-chloroethyl)-1-nitrosourea in vitro. (1978) (30)
- Expression of mammalian O6-alkylguanine-DNA alkyltransferase in a cell line sensitive to alkylating agents. (1989) (30)
- The role of O-6 methylguanine DNA methyltransferase (MGMT) in drug resistance and strategies for its inhibition. (1991) (29)
- Expression of ribosomal phosphoprotein PO is induced by antitumor agents and increased in Mer- human tumor cell lines. (1992) (28)
- Gene-specific DNA interstrand cross-links produced by nitrogen mustard in the human tumor cell line Colo320HSR. (1992) (28)
- Changes in c-myc and c-fos expression in a human tumor cell line following exposure to bifunctional alkylating agents. (1990) (27)
- Effects of carbamoylation on cell survival and DNA repair in normal human embryo cells (IMR-90) treated with various 1-(2-chloroethyl)-1-nitrosoureas. (1984) (27)
- DNA damage and differential cytotoxicity produced in human cells by 2-chloroethyl (methylsulfonyl)methanesulfonate (NSC 338947), a new DNA-chloroethylating agent. (1985) (27)
- Combined effects of streptozotocin and mitozolomide against four human cell lines of the Mer+ phenotype. (1986) (26)
- Mechanisms for the production of DNA damage in cultured human and hamster cells irradiated with light from fluorescent lamps, sunlamps, and the sun. (1980) (25)
- Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylguanine in vitro and in vivo. (1999) (24)
- Retroviral-mediated expression of the P140A, but not P140A/G156A, mutant form of O6-methylguanine DNA methyltransferase protects hematopoietic cells against O6-benzylguanine sensitization to chloroethylnitrosourea treatment. (1999) (23)
- Bacterial mutagenesis and host cell DNA damage by chemical carcinogens in the Salmonella/hepatocyte system. (1980) (22)
- A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase (2006) (21)
- Anti-neoplastic activity of sequenced administration of O6-benzylguanine, streptozotocin, and 1,3-bis(2-chloroethyl)-1-nitrosourea in vitro and in vivo. (1994) (20)
- DNA–Damaging and Transcription‐Terminating Lesions Induced by AF64A In Vitro (1992) (20)
- Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity. (1994) (19)
- Mutagenicity and DNA damage induced by arylamines in the Salmonella/hepatocyte system. (1983) (19)
- Synthesis of radiolabeled O6‐benzylguanine derivatives as new potential PET tumor imaging agents for the DNA repair protein O6‐alkylguanine‐DNA alkyltransferase (2002) (16)
- Effect of dose, schedule, and route of administration on the in vivo toxicity and antitumor activity of two activated sulfhydryl derivatives of cyclophosphamide. (1980) (15)
- Comparison of DNA interstrand cross-linking and strand breakage by 1,3-bis(2-chloroethyl)-1-nitrosourea in polyamine-depleted and control human adenocarcinoma cells. (1987) (15)
- Synthesis and preliminary biological evaluation of 6-O-[11C]-[(methoxymethyl)benzyl]guanines, new potential PET breast cancer imaging agents for the DNA repair protein AGT. (2003) (14)
- Inhibition of cis-diammine-1,1-cyclobutane dicarboxylatoplatinum(II)-induced DNA interstand cross-link removal and potentiation of cis-diammine-1,1-cyclobutane dicarboxylatoplatinum(II) cytotoxicity by hydroxyurea and 1-beta-D-arabinofuranosylcytosine. (1991) (14)
- Preservation of DNA integrity in human and mouse leukemic cells induced to terminally differentiate by chemical agents. (1981) (12)
- Ultraviolet irradiation produces cytotoxic synergy and increased DNA interstrand crosslinking with cis- and trans-diamminedichloroplatinum(II). (1989) (12)
- Cytotoxic synergy of cisplatin with concurrent hydroxyurea and cytarabine: summary of an in vitro model and initial clinical pilot experience. (1992) (11)
- A Convenient Procedure for the Synthesis of O6-Benzylguanine Derivatives by Phase Transfer Catalysis (2003) (11)
- The effects of pretreatment of human tumour cells with MNNG on the DNA crosslinking and cytotoxicity of mitozolomide. (1985) (9)
- Combined effect of trans-diamminedichloroplatinum(II) and hyperthermia on murine and human tumor cells. (1985) (9)
- A filter incubation method for the determination of potentially crosslinkable sites in DNA in mammalian cells. (1985) (9)
- In vitro transcription termination by N,N'-bis(2-chloroethyl)-N-nitrosourea-induced DNA lesions. (1995) (8)
- The effect of misonidazole on the cytotoxicity and DNA cross-linking activity of an activated sulfidocyclophosphamide in hypoxic mouse leukemia cells. (1982) (7)
- Hammerhead Ribozyme-Mediated Sensitization of Human Tumor Cells after Treatment with 1,3-Bis(2-chloroethyl)-1-nitrosourea (2004) (7)
- Differential cytotoxicity and DNA cross-linking produced by polymeric and monomeric activated analogues of cyclophosphamide in mouse L1210 leukemia cells. (1981) (7)
- Isolation and purification of large quantities of DNA replication intermediates by pH step alkaline elution (2004) (7)
- Evaluation of mitoxantrone accumulation and multidrug resistance transporters in prostate cancer cells (2004) (6)
- Differential Cytotoxicity and DMACross-Linkingin Normal and Transformed Human FibroblastsTreated with c/s- Diamminedichloroplatinum(ll)1 (1981) (6)
- Pretreatment of Human Colon Tumor Cells with DNA Methylating Agents Inhibits their Ability to Prevent Chloroethylnitrosourea-Induced DNA Interstrand Crosslinking (1984) (6)
- Induction and repair of macromolecular damage by alkylating agents. (1984) (6)
- Modulation of 1,3-bis-(2-chloroethyl)-1-nitrosourea resistance in human tumor cells using hammerhead ribozymes designed to degrade O6-methylguanine DNA methyltransferase mRNA. (2001) (6)
- Differential cyto toxicity and dna cross linking in normal and transformed human fibroblasts treated with cisplatin in vitro (1980) (6)
- Cytotoxic and dna damaging effects of af64a in cholinergic and non cholinergic human cell lines (1988) (5)
- Cisplatin preceded by concurrent cytarabine and hydroxyurea: a pilot study based on an in vitro model (2004) (4)
- Genotoxicity of N-acetylarylamines in the Salmonella/hepatocyte system (1983) (4)
- 11 – Preclinical and Clinical Experiences with Drug Combinations Designed to Inhibit DNA Repair in Resistant Human Tumor Cells (1988) (4)
- AF64A-induced cytotoxicity and changes in choline acetyltransferase activity in the LA-N-2 neuroblastoma cell line are modulated by choline and hemicholinium-3 (1995) (3)
- Synthesis and preliminary biological evaluation of O6-[4-(2-[18F]fluoroethoxymethyl)benzyl]guanine as a novel potential PET probe for the DNA repair protein O6-alkylguanine-DNA alkyltransferase in cancer chemotherapy. (2005) (3)
- Gene amplification affecting O(6)-alkylguanine-DNA alkyltransferase activity is not detected in nitrosourea resistant or sensitive human cell lines. (1990) (3)
- The alkaline elution method and its application to studies of the formation and repair of DNA single-strand breaks and cross-links in UV-irradiated human fibroblasts (1977) (2)
- AF64A-Induced Changes In N-myc Expression in the LA-N-2 Human Neuroblastoma Cell Line are Modulated by Choline and Hemicholinium-3 (1998) (2)
- Quantitation of mitoxantrone accumulation, efflux and modulation in MDR human MDA-MB-435 cancer cells (2005) (1)
- Sensitization of Resistant Human Tumor Cells to Cisplatin or Carboplatin by Inhibitors of DNA Excision Repair (1991) (1)
- Differences in DNA crosslinking in normal and transformed human cells treated with chloroethylnitrosoureas (1979) (0)
- l-/3-D-Arabinofuranosylcytosine and Hydroxyurea Production of Cytotoxic Synergy with cis-Diamminedichloroplatinum(II) and Modification of Platinum-induced DNA Interstrand Cross-Linking1 (2006) (0)
- Preparative hplc analysis of the interaction of chloroethyl- -nitrosoureas with the cellular dna of l1210 cells in culture. Abstr. (1983) (0)
- ComparativeStudiesof DNA Cross-Linkingand Cytotoxicityin Burkitt ' s LymphomaCell LinesTreated with cis-Diamminedichloroplatinum ( ll ) and L-PhenylalanineMustard (2006) (0)
- Cytotoxicity and DMA Cross-Linking Activity of 4-Sulfidocyclophosphamides in Mouse Leukemia Cells in V/'tro1 (2006) (0)
- m-AMSA serum levels vs. m-AMSA induced lymphocyte (PBL) DNA breakage as an indicator of delivered drug during a phase I-II trial of continuous infusion of m-AMSA (1982) (0)
- Line following Exposure to Bifunctional Alkylating Agents Expression in a Human Tumor Cell fos and c-myc Changes in c-Updated (2006) (0)
- Quantification of drug uptake, efflux and modulation in MDR cells in vitro and in vivo (2008) (0)
- Effect of 06-Methylguanine on DNA Interstrand Chloroethylnitrosoureas and Z-ChloroethyKmethylsulfonyOmethanesulfonate1 (2006) (0)
- DMA Cross-Linking and Cytotoxicity Induced by c/s-Diamminedichloroplatinum(ll) in Human Normal and Tumor Cell Lines (2006) (0)
- Genotoxicity of N*Acetylarylarines in the SalmonellalHepatocyte System (2006) (0)
- DNA lesions and cytotoxicity by 4'-(9-acridinylamino) methanesulfon-m-anisidide (m-AMSA) and adriamycin (ADR) (1981) (0)
- Combined Effect of frans-Diamminedichloroplatinum(ll) and Hyperthermia on Murine and Human Tumor Cells1 (2006) (0)
- Measurements of DMA Damage in Chinese Hamster Cells Treated with Equitoxic and Equimutagenic Doses of Nitrosoureas1 (2006) (0)
- Measurements of chemical interactions with dna (1985) (0)
- Size-fractionation of dna single strands from mammalian cells by alkaline elution. Abstr. (1975) (0)
- Genotoxicity of NsAcetylarylarines in the SalmonellalHepatocyte System (2016) (0)
- Comparative kinetics of dna crosslinking in vitro with anti-tumor activity in vivo of a monomeric and a polymeric analog of cyclophosphamide. Abstr. (1980) (0)
- DNA Cross-Linking and Cytotoxicity in Normal and Transformed Human Cells Treated in vitro with M&B 39565 (1984) (0)
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