Leonard Katz
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Leonard Katzbiology Degrees
Biology
#14713
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#18541
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Biochemistry
#2579
World Rank
#2748
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Chemistry Biology
Leonard Katz's Degrees
- PhD Biochemistry Stanford University
- Bachelors Chemistry University of California, Berkeley
Why Is Leonard Katz Influential?
(Suggest an Edit or Addition)Leonard Katz's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Modular organization of genes required for complex polyketide biosynthesis. (1991) (768)
- Natural product discovery: past, present, and future (2016) (614)
- Stimulation by Cyclic Adenosine Monophosphate of Plasmid Deoxyribonucleic Acid Replication and Catabolite Repression of the Plasmid Deoxyribonucleic Acid-Protein Relaxation Complex (1973) (369)
- Cloning and heterologous expression of the epothilone gene cluster. (2000) (363)
- Polyketide synthesis: prospects for hybrid antibiotics. (1993) (338)
- New directions in antibacterial research. (1996) (253)
- The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units. (2000) (238)
- Organization of the enzymatic domains in the multifunctional polyketide synthase involved in erythromycin formation in Saccharopolyspora erythraea. (1992) (222)
- Engineered biosynthesis of a complete macrolactone in a heterologous host. (1994) (217)
- Manipulation of Modular Polyketide Synthases. (1997) (208)
- Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production. (1997) (163)
- Translation and protein synthesis: macrolides. (2005) (160)
- Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum. (2000) (156)
- An erythromycin analog produced by reprogramming of polyketide synthesis. (1993) (150)
- Manipulation of macrolide ring size by directed mutagenesis of a modular polyketide synthase (1995) (146)
- Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives (1997) (121)
- Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering. (1998) (119)
- Natural products as biofuels and bio-based chemicals: fatty acids and isoprenoids. (2015) (112)
- Identification of a Saccharopolyspora erythraea gene required for the final hydroxylation step in erythromycin biosynthesis (1993) (107)
- Identification and characterization of the niddamycin polyketide synthase genes from Streptomyces caelestis (1997) (100)
- Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis. (1999) (98)
- Unidirectional replication of plasmid ColE1 DNA (1974) (95)
- Comprehensive in Vitro Analysis of Acyltransferase Domain Exchanges in Modular Polyketide Synthases and Its Application for Short-Chain Ketone Production. (2017) (82)
- Characterization of the genetic elements required for site-specific integration of plasmid pSE211 in Saccharopolyspora erythraea (1990) (79)
- The structure of VanX reveals a novel amino-dipeptidase involved in mediating transposon-based vancomycin resistance. (1998) (78)
- ENGINEERED BIOSYNTHESIS OF A TRIKETIDE LACTONE FROM AN INCOMPLETE MODULAR POLYKETIDE SYNTHASE (1994) (77)
- Cloning of genes involved in erythromycin biosynthesis from Saccharopolyspora erythraea using a novel actinomycete-Escherichia coli cosmid. (1990) (73)
- Overproduction and characterization of the erythromycin C-12 hydroxylase, EryK. (1995) (70)
- Elucidating the mechanism of cis double bond formation in epothilone biosynthesis. (2004) (69)
- Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function. (1998) (69)
- Biosynthesis of the anti‐parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea (2000) (66)
- Mutation and cloning of eryG, the structural gene for erythromycin O-methyltransferase from Saccharopolyspora erythraea, and expression of eryG in Escherichia coli (1990) (63)
- Engineered Biosynthesis of Structurally Diverse Tetraketides by a Trimodular Polyketide Synthase (1996) (63)
- Chalcomycin Biosynthesis Gene Cluster from Streptomyces bikiniensis: Novel Features of an Unusual Ketolide Produced through Expression of the chm Polyketide Synthase in Streptomyces fradiae (2004) (62)
- Development of Next Generation Synthetic Biology Tools for Use in Streptomyces venezuelae. (2017) (62)
- Engineering a Polyketide Synthase for In Vitro Production of Adipic Acid. (2016) (62)
- Genome-based bioprospecting of microbes for new therapeutics. (2012) (57)
- New antibiotics from genetically engineered actinomycetes. I. 2-Norerythromycins, isolation and structural determinations. (1987) (56)
- Production of anteiso-branched fatty acids in Escherichia coli; next generation biofuels with improved cold-flow properties. (2014) (56)
- Induction of ribosome methylation in MLS-resistant Streptococcus pneumoniae by macrolides and ketolides. (1999) (56)
- Isolation, cloning, and expression of a 70-kilodalton plasminogen binding protein of Borrelia burgdorferi (1997) (55)
- A second type-I PKS gene cluster isolated from Streptomyces hygroscopicus ATCC 29253, a rapamycin-producing strain. (1997) (55)
- ClusterCAD: a computational platform for type I modular polyketide synthase design (2017) (52)
- Narrowing the gap between the promise and reality of polyketide synthases as a synthetic biology platform. (2014) (52)
- A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus. (2002) (51)
- Leveraging microbial biosynthetic pathways for the generation of 'drop-in' biofuels. (2017) (49)
- Development of an orthogonal fatty acid biosynthesis system in E. coli for oleochemical production. (2015) (46)
- Synthetic biology advances and applications in the biotechnology industry: a perspective (2018) (46)
- The loading domain of the erythromycin polyketide synthase is not essential for erythromycin biosynthesis in Saccharopolyspora erythraea. (1998) (44)
- Biosynthesis of the erythromycin macrolactone and a rational approach for producing hybrid macrolides. (1992) (44)
- Heterologous production of polyketides by modular type I polyketide synthases in Escherichia coli. (2012) (43)
- Site-specific integration in Saccharopolyspora erythraea and multisite integration in Streptomyces lividans of actinomycete plasmid pSE101 (1988) (43)
- Novel macrolides through genetic engineering (1999) (42)
- Production of hybrid 16-membered macrolides by expressing combinations of polyketide synthase genes in engineered Streptomyces fradiae hosts. (2004) (42)
- The Antifungal Polyketide Ambruticin Targets the HOG Pathway (2007) (41)
- The Group III Two-Component Histidine Kinase of Filamentous Fungi Is Involved in the Fungicidal Activity of the Bacterial Polyketide Ambruticin (2008) (40)
- The DEBS paradigm for type I modular polyketide synthases and beyond. (2009) (40)
- Short-chain ketone production by engineered polyketide synthases in Streptomyces albus (2018) (40)
- Gene disruption and replacement in the rapamycin-producing Streptomyces hygroscopicus strain ATCC 29253. (1997) (36)
- A New Substrate Specificity for Acyl Transferase Domains of the Ascomycin Polyketide Synthase in Streptomyces hygroscopicus * (2002) (36)
- Proton magnetic resonance investigation of the association of adenine and uracil derivatives in chloroform solution. (1969) (35)
- Generation of New Epothilones by Genetic Engineering of a Polyketide Synthase in Myxococcus xanthus (2005) (34)
- Broad substrate specificity of the loading didomain of the lipomycin polyketide synthase. (2013) (33)
- Purification and characterization of covalently closed replicative intermediates of ColEl DNA from Escherichia coli. (1977) (32)
- Manual of Industrial Microbiology and Biotechnology, Third Edition (2010) (32)
- Gene dosage effect on the expression of the delta-endotoxin genes of Bacillus thuringiensis subsp. kurstaki in Bacillus subtilis and Bacillus megaterium. (1989) (32)
- New Directions in Antibacterial Research (1997) (29)
- Engineered biosynthesis of 16-membered macrolides that require methoxymalonyl-ACP precursors in Streptomyces fradiae (2004) (28)
- The Chemistry of Polycyclic Aromatic Hydrocarbon-DNA Adducts (1980) (28)
- Characterization of the macromolecular synthesis (MMS) operon from Listeria monocytogenes. (1994) (26)
- Synthetic biology of polyketide synthases (2018) (26)
- Hyperinducibility as a Result of Mutation in Structural Genes and Self-Catabolite Repression in the ara Operon (1971) (25)
- Substrate requirements for ErmC' methyltransferase activity (1995) (25)
- Divergent mechanistic routes for the formation of gem-dimethyl groups in the biosynthesis of complex polyketides. (2015) (25)
- Characterization of the genes and attachment sites for site-specific integration of plasmid pSE101 in Saccharopolyspora erythraea and Streptomyces lividans (2004) (24)
- Erythromycin production in Saccharopolyspora erythraea does not require a functional propionyl‐CoA carboxylase (1996) (22)
- In vitro analysis of carboxyacyl substrate tolerance in the loading and first extension modules of borrelidin polyketide synthase. (2014) (22)
- Efficacy of Ambruticin Analogs in a Murine Model of Coccidioidomycosis (2006) (22)
- Alteration of Polyketide Stereochemistry from anti to syn by a Ketoreductase Domain Exchange in a Type I Modular Polyketide Synthase Subunit. (2016) (22)
- Expression of the macrolide-lincosamide-streptogramin-B-resistance methylase gene, ermE, from Streptomyces erythraeus in Escherichia coli results in N6-monomethylation and N6,N6-dimethylation of ribosomal RNA. (1987) (21)
- Precursor-directed biosynthesis of 6-deoxyerythronolide B analogues is improved by removal of the initial catalytic sites of the polyketide synthase (2006) (20)
- Erythromycin biosynthesis. Highly efficient incorporation of polyketide chain elongation intermediates into 6-deoxyerythronolide B in an engineered Streptomyces host. (1995) (19)
- Generation of novel epothilone analogs with cytotoxic activity by biotransformation. (2003) (19)
- On the Mechanism of Action of 9-O-Arylalkyloxime Derivatives of 6-O-Mycaminosyltylonolide, a New Class of 16-Membered Macrolide Antibiotics (2006) (18)
- Probing the Flexibility of an Iterative Modular Polyketide Synthase with Non-Native Substrates in Vitro. (2018) (18)
- A High Capacity Microbial Screen for Inhibitors of Human Rhinovirus Protease 3C (1994) (18)
- High-level expression and purification of mature HIV-1 protease in Escherichia coli under control of the araBAD promoter (1992) (18)
- Insights into polyketide biosynthesis gained from repurposing antibiotic-producing polyketide synthases to produce fuels and chemicals (2016) (17)
- Antibiotic production from the ground up (2007) (17)
- Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challenges (2016) (17)
- Construction of a part of a 3-hydroxypropionate cycle for heterologous polyketide biosynthesis in Escherichia coli. (2012) (14)
- Selection of AraB and AraC Mutants of Escherichia coli B/r by Resistance to Ribitol (1970) (14)
- Efficacy of Ambruticin Analogs in a Murine Model of Invasive Pulmonary Aspergillosis (2006) (14)
- Engineered Production of Short-Chain Acyl-Coenzyme A Esters in Saccharomyces cerevisiae. (2018) (13)
- Chapter 14. Genetic Engineering of Antibiotic Producing Organisms (1992) (13)
- Nucleotide sequence of the ermE distal flank of the erythromycin biosynthesis cluster in Saccharopolyspora erythraea. (1997) (12)
- Site-specific recombination in Escherichia coli between the att sites of plasmid pSE211 from Saccharopolyspora erythraea. (1991) (12)
- Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides. (2006) (11)
- Chemoinformatic-guided engineering of polyketide synthases (2019) (11)
- Characterization of bacteriophage phi C69 of Saccharopolyspora erythraea and demonstration of heterologous actinophage propagation by transfection of Streptomyces and Saccharopolyspora. (1988) (10)
- Effect of Inhibitors of Ribonucleic Acid and Protein Synthesis on the Cyclic Adenosine Monophosphate Stimulation of Plasmid ColE1 Replication (1974) (9)
- Heterologous Gene Expression of N-Terminally Truncated Variants of LipPks1 Suggests a Functionally Critical Structural Motif in the N-terminus of Modular Polyketide Synthase. (2017) (9)
- Enzyme analysis of the polyketide synthase leads to the discovery of a novel analog of the antibiotic α-lipomycin (2013) (9)
- Understanding the Role of Histidine in the GHSxG Acyltransferase Active Site Motif: Evidence for Histidine Stabilization of the Malonyl-Enzyme Intermediate (2014) (7)
- Commodity Chemicals From Engineered Modular Type I Polyketide Synthases. (2018) (7)
- Plasmid−chromosome interactions in Saccharopolyspora erythraea and Streptomyces lividans (1988) (7)
- CHAPTER 14 – Macrolides (1995) (7)
- Development of a Coupled VanA/VanX Assay: Screening for Inhibitors of Glycopeptide Resistance (1997) (7)
- Structural mechanism of regioselectivity in an unusual bacterial acyl-CoA dehydrogenase (2019) (6)
- Electron-microscopic study of L-like colonies of the cyanobacterium Chlorogloea fritschii (1983) (6)
- Generation of New Epothilones by Genetic Engineering of a Polyketide Synthase in Myxococcus xanthus. (2005) (5)
- Biosynthesis of the antiparasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea (2001) (5)
- Investigating Amine Derivatives of Ambruticin VS‐5 and VS‐4 (2008) (3)
- Introduction to the Special Issue: “Natural Product Discovery and Development in the Genomic Era” (2016) (3)
- Chapter 12. Bacterial Genomics and the Search for Novel Antibiotics (1997) (3)
- Site-specific recombination inEscherichia coli between theatt sites of plasmid pSE211 fromSaccharopolyspora erythraea (1991) (2)
- A bimodular PKS platform that expands the biological design space. (2020) (2)
- Sir David Alan Hopwood (2003) (1)
- Engineering Polyketide Synthases (2002) (1)
- Translation and Protein Synthesis: Macrolides (2005) (1)
- Short-chain ketone production by engineered polyketide synthases in Streptomyces albus (2018) (0)
- Cyclic Adenosine Monophosphate Stimulation of Plasmid ColEl Replication (0)
- Heterologist preparation of polycetides (2001) (0)
- erythromycin biosynthesis. in gene required for the final hydroxylation step Identification of a Saccharopolyspora erythraea (2013) (0)
- Manipulation of Modular Polyketide Synthases (1998) (0)
- Efficacy of Ambruticin Analogs in a Murine Model of Invasive Pulmonary Aspergillosis (2006) (0)
- Production de biocarburants en utilisant des polykétide synthases (2009) (0)
- Sir David Alan Hopwood (2003) (0)
- Antisense oligonucleotide antibiotic complementary to macromglecular synthesis operon, treatment of bacterial infection and identification of bacterium (1991) (0)
- Lawrence Berkeley National Laboratory Recent Work Title Short-chain ketone production by engineered polyketide synthases in Streptomyces (2018) (0)
- Crystal Structure of VanX (2004) (0)
- Consequences of interaction between F plasmid and a drug-resistance plasmid belonging to incompatibility group F1. (1980) (0)
- Structural GenesandSelf-Catabolite Repression (1971) (0)
- Expanding Extender Substrate Selection for Unnatural Polyketide Biosynthesis by Acyltransferase Domain Exchange within a Modular Polyketide Synthase (2023) (0)
- A bimodular PKS platform that expands the biological design space (2020) (0)
- Novel polyketides from genetic engineering (... and lessons we have learned from making them) (2007) (0)
- Engineered Biosynthesis ofaComplete Macrolactone ina Heterologous Host (2016) (0)
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Leonard Katz is affiliated with the following schools:
