Leonard P Guarente
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(Suggest an Edit or Addition)Leonard P Guarente's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase (2000) (3230)
- hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase (2001) (2479)
- The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. (1999) (2145)
- Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ (2004) (1934)
- Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans (2001) (1931)
- Negative Control of p53 by Sir2α Promotes Cell Survival under Stress (2001) (1877)
- Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. (2000) (1803)
- The Sir2 family of protein deacetylases. (2004) (1532)
- Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia (2011) (1502)
- Extrachromosomal rDNA Circles— A Cause of Aging in Yeast (1997) (1435)
- Mammalian SIRT1 Represses Forkhead Transcription Factors (2004) (1400)
- Genetic pathways that regulate ageing in model organisms (2000) (1318)
- The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control (2008) (1282)
- Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. (2006) (1274)
- Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6 (2006) (1229)
- Negative control of p53 by Sir2alpha promotes cell survival under stress. (2001) (1145)
- Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation (2007) (1116)
- SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells (2006) (1084)
- Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration (2002) (1059)
- Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast. (1983) (1005)
- Calorie restriction, SIRT1 and metabolism: understanding longevity (2005) (978)
- The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling (2013) (917)
- NAD+ and sirtuins in aging and disease. (2014) (877)
- Five intermediate complexes in transcription initiation by RNA polymerase II (1989) (863)
- Calorie Restriction— the SIR2 Connection (2005) (793)
- SIRT1 and other sirtuins in metabolism (2014) (776)
- High-efficiency transformation of yeast by electroporation. (1991) (742)
- SIRT1 transgenic mice show phenotypes resembling calorie restriction (2007) (717)
- Sir2 links chromatin silencing, metabolism, and aging. (2000) (713)
- Molecular Biology of Aging (1999) (697)
- Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells (2005) (695)
- Calorie restriction extends yeast life span by lowering the level of NADH. (2004) (646)
- SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle (2009) (640)
- Two neurons mediate diet-restriction-induced longevity in C. elegans (2007) (633)
- SIRT1 deacetylates and positively regulates the nuclear receptor LXR. (2007) (622)
- The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth (2008) (606)
- Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. (2006) (583)
- Tissue-specific regulation of SIRT1 by calorie restriction. (2008) (547)
- Mouse Sir2 Homolog SIRT6 Is a Nuclear ADP-ribosyltransferase* (2005) (541)
- Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site (1983) (533)
- A Fasting Inducible Switch Modulates Gluconeogenesis Via Activator-Coactivator Exchange (2008) (513)
- Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins? (2008) (502)
- How does calorie restriction work? (2003) (489)
- SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging (2013) (487)
- Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae (1995) (482)
- A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site. (1982) (464)
- Essential role of limiting telomeres in the pathogenesis of Werner syndrome (2004) (450)
- Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. (2003) (444)
- Genetics and the Specificity of the Aging Process (2003) (442)
- Increase in Activity During Calorie Restriction Requires Sirt1 (2005) (438)
- Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains (1992) (436)
- Sirtuins as potential targets for metabolic syndrome (2006) (435)
- A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. (2005) (428)
- Franklin H. Epstein Lecture: Sirtuins, aging, and medicine. (2011) (423)
- Genetic links between diet and lifespan: shared mechanisms from yeast to humans (2007) (420)
- SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production (2011) (417)
- Fusion of Escherichia coli lacZ to the cytochrome c gene of Saccharomyces cerevisiae. (1981) (407)
- Distinctly regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of S. cerevisiae (1984) (395)
- Identification and characterization of HAP4: a third component of the CCAAT-bound HAP2/HAP3 heteromer. (1989) (394)
- Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. (1997) (393)
- Elimination of replication block protein Fob1 extends the life span of yeast mother cells. (1999) (390)
- Calorie restriction and sirtuins revisited (2013) (389)
- Redistribution of Silencing Proteins from Telomeres to the Nucleolus Is Associated with Extension of Life Span in S. cerevisiae (1997) (388)
- Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. (2010) (379)
- C. elegans SIR-2.1 Interacts with 14-3-3 Proteins to Activate DAF-16 and Extend Life Span (2006) (375)
- The multifaceted functions of sirtuins in cancer (2015) (346)
- SIRTUINS, AGING AND DISEASE (2010) (345)
- Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes (2013) (344)
- SIRT1 in Neurodevelopment and Brain Senescence (2014) (341)
- MEC1-Dependent Redistribution of the Sir3 Silencing Protein from Telomeres to DNA Double-Strand Breaks (1999) (333)
- RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10 (2010) (327)
- Sirt1 mediates neuroprotection from mutant huntingtin by activation of TORC1 and CREB transcriptional pathway (2011) (327)
- SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. (2012) (319)
- High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction. (2012) (314)
- Aging and disease: connections to sirtuins (2010) (308)
- Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span (1994) (304)
- Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells (2013) (301)
- Sirtuins mediate mammalian metabolic responses to nutrient availability (2012) (301)
- Cloning of yeast HAP5: a novel subunit of a heterotrimeric complex required for CCAAT binding. (1995) (288)
- Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors. (1994) (287)
- Loss of Transcriptional Silencing Causes Sterility in Old Mother Cells of S. cerevisiae (1996) (286)
- Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver (2011) (286)
- Functional dissection and sequence of yeast HAP1 activator (1989) (282)
- Heme binds to a short sequence that serves a regulatory function in diverse proteins. (1995) (279)
- Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging (2018) (277)
- Sirtuins at a glance (2011) (271)
- Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: Evidence for transcriptional adaptors (1990) (269)
- Function of a yeast TATA element-binding protein in a mammalian transcription system (1988) (268)
- Each of three "TATA elements" specifies a subset of the transcription initiation sites at the CYC-1 promoter of Saccharomyces cerevisiae. (1985) (264)
- The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase (2001) (263)
- It takes two to tango: NAD+ and sirtuins in aging/longevity control (2016) (259)
- Synthetic enhancement in gene interaction: a genetic tool come of age. (1993) (248)
- Proteolipid Protein Is Required for Transport of Sirtuin 2 into CNS Myelin (2007) (242)
- Yeast TATA-binding protein TFIID binds to TATA elements with both consensus and nonconsensus DNA sequences. (1989) (236)
- Yeast HAP1 activator binds to two upstream activation sites of different sequence (1987) (229)
- Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. (2014) (227)
- SIRT1 Inhibits Transforming Growth Factor β-Induced Apoptosis in Glomerular Mesangial Cells via Smad7 Deacetylation* (2007) (220)
- Nucleolar localization of the Werner syndrome protein in human cells. (1998) (214)
- Telomere Shortening Exposes Functions for the Mouse Werner and Bloom Syndrome Genes (2004) (211)
- The SirT3 divining rod points to oxidative stress. (2011) (208)
- Isolation of the gene encoding the yeast TATA binding protein TFIID: A gene identical to the SPT15 suppressor of Ty element insertions (1989) (205)
- A yeast and a human CCAAT-binding protein have heterologous subunits that are functionally interchangeable (1988) (205)
- mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction (2016) (204)
- Nuclear structure in normal and Bloom syndrome cells. (2000) (201)
- Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. (2013) (198)
- Yeast HAP2 and HAP3 activators both bind to the CYC1 upstream activation site, UAS2, in an interdependent manner (1987) (198)
- SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive (2011) (195)
- Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes (2011) (195)
- SIR2: a potential target for calorie restriction mimetics. (2007) (192)
- Small-molecule allosteric activators of sirtuins. (2013) (191)
- The HAP2 subunit of yeast CCAAT transcriptional activator contains adjacent domains for subunit association and DNA recognition: model for the HAP2/3/4 complex. (1990) (190)
- A cDNA encoding a human CCAAT-binding protein cloned by functional complementation in yeast. (1991) (189)
- SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones (2012) (189)
- Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction. (2009) (185)
- A therapeutic role for sirtuins in diseases of aging? (2007) (184)
- SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin (2013) (183)
- Improved methods for maximizing expression of a cloned gene: a bacterium that synthesizes rabbit β-globin (1980) (183)
- Sirtuin deacetylases in neurodegenerative diseases of aging (2013) (182)
- ADA3, a putative transcriptional adaptor, consists of two separable domains and interacts with ADA2 and GCN5 in a trimeric complex (1995) (181)
- Sirtuins, aging, and metabolism. (2011) (181)
- Aging in Saccharomyces cerevisiae. (1998) (178)
- Mutations in the WRN Gene in Mice Accelerate Mortality in a p53-Null Background (2000) (176)
- Superoxide Dismutase 1 Knock-down Induces Senescence in Human Fibroblasts* (2003) (176)
- SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis. (2013) (176)
- Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells. (2000) (175)
- Calorie restriction and SIR2 genes—Towards a mechanism (2005) (172)
- Communication between mitochondria and the nucleus in regulation of cytochrome genes in the yeast Saccharomyces cerevisiae. (1989) (167)
- Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae. (1999) (165)
- Mutations in yeast HAP2/HAP3 define a hybrid CCAAT box binding domain. (1993) (159)
- Effects of Mutations in DNA Repair Genes on Formation of Ribosomal DNA Circles and Life Span inSaccharomyces cerevisiae (1999) (159)
- Diverse and dynamic functions of the Sir silencing complex (1999) (158)
- Yeast HAP1 activator competes with the factor RC2 for binding to the upstream activation site UAS1 of the CYC1 gene (1987) (157)
- Yeast promoters: Positive and negative elements (1984) (152)
- UASs and enhancers: Common mechanism of transcriptional activation in yeast and mammals (1988) (150)
- Sir2: an NAD-dependent histone deacetylase that connects chromatin silencing, metabolism, and aging. (2000) (150)
- Upstream activation sites of the CYC1 gene of Saccharomyces cerevisiae are active when inverted but not when placed downstream of the "TATA box". (1984) (148)
- Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria. (2004) (148)
- Transcriptional coactivators in yeast and beyond. (1995) (145)
- Saccharomyces cerevisiae contains two functional citrate synthase genes (1986) (143)
- High Osmolarity Extends Life Span in Saccharomyces cerevisiae by a Mechanism Related to Calorie Restriction (2002) (142)
- SIRT1 Suppresses b-Amyloid Production by Activating the a-Secretase Gene ADAM10 (2010) (141)
- Vectors for expression of cloned genes in yeast: regulation, overproduction, and underproduction. (1991) (137)
- Regulatory proteins in yeast. (1987) (135)
- Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres. (2000) (135)
- Model organisms as a guide to mammalian aging. (2002) (133)
- Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. (2002) (133)
- Striking conservation of TFIID in Schizosaccharomyces pombe and Saccharomyces cerevisiae (1990) (132)
- Cloning and molecular analysis of the HAP2 locus: a global regulator of respiratory genes in Saccharomyces cerevisiae (1985) (130)
- SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo (2012) (128)
- Yeast HAP2 and HAP3: transcriptional activators in a heteromeric complex. (1988) (123)
- Sequence and nuclear localization of the Saccharomyces cerevisiae HAP2 protein, a transcriptional activator (1987) (121)
- Molecular mechanisms of yeast aging. (1998) (121)
- The brain, sirtuins, and ageing (2017) (120)
- Yeast ADA2 protein binds to the VP16 protein activation domain and activates transcription. (1994) (117)
- Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study (2017) (117)
- ADA3: a gene, identified by resistance to GAL4-VP16, with properties similar to and different from those of ADA2. (1993) (116)
- Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co‐activator PC4. (1996) (116)
- Isolation, sequence, and regulation by oxygen of the yeast HEM13 gene coding for coproporphyrinogen oxidase. (1988) (113)
- Mutational analysis of upstream activation sequence 2 of the CYC1 gene of Saccharomyces cerevisiae: a HAP2-HAP3-responsive site (1988) (113)
- The HAP3 regulatory locus of Saccharomyces cerevisiae encodes divergent overlapping transcripts (1988) (113)
- Evidence for BLM and Topoisomerase IIIα interaction in genomic stability (2001) (112)
- SIRT1 promotes differentiation of normal human keratinocytes. (2009) (111)
- Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c–SIRT2 axis (2017) (109)
- Molecular links between aging and adipose tissue (2005) (109)
- ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3 (1997) (107)
- A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. (2000) (106)
- Link between aging and the nucleolus. (1997) (105)
- Mitochondrial and nonmitochondrial citrate synthases in Saccharomyces cerevisiae are encoded by distinct homologous genes (1986) (102)
- The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination. (2001) (102)
- ADA5/SPT20 links the ADA and SPT genes, which are involved in yeast transcription (1996) (100)
- Roles of SIRT1 in the Acute and Restorative Phases following Induction of Inflammation* (2010) (97)
- SIRT1-mediated acute cardioprotection. (2011) (95)
- Muscle-Specific SIRT1 Gain-of-Function Increases Slow-Twitch Fibers and Ameliorates Pathophysiology in a Mouse Model of Duchenne Muscular Dystrophy (2014) (93)
- The yeast activator HAP1--a GAL4 family member--binds DNA in a directly repeated orientation. (1994) (91)
- Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota. (2017) (90)
- Expression of the human fibroblast interferon gene in Escherichia coli. (1980) (89)
- The Saccharomyces cerevisiae Hap5p homolog from fission yeast reveals two conserved domains that are essential for assembly of heterotetrameric CCAAT-binding factor (1997) (88)
- Increased Life Span due to Calorie Restriction in Respiratory-Deficient Yeast (2006) (85)
- NAD+ supplementation rejuvenates aged gut adult stem cells (2019) (85)
- SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism. (2014) (83)
- Dyskeratosis congenita, telomeres and human ageing. (2000) (83)
- Regulation of the yeast CYT1 gene encoding cytochrome c1 by HAP1 and HAP2/3/4 (1991) (83)
- Telomeres, the nucleolus and aging. (1998) (82)
- Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway (2016) (81)
- Mutant lambda phage repressor with a specific defect in its positive control function. (1982) (81)
- Sirtuins, Aging, and Medicine (2011) (80)
- A novel telomere structure in a human alternative lengthening of telomeres cell line. (2005) (79)
- Structure of a HAP1–DNA complex reveals dramatically asymmetric DNA binding by a homodimeric protein (1999) (79)
- The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration (2008) (77)
- SIRT1 Shows No Substrate Specificity in Vitro* (2005) (77)
- The logic linking protein acetylation and metabolism. (2011) (76)
- Metabolic and neuropsychiatric effects of calorie restriction and sirtuins. (2013) (75)
- Unlocking the secrets of longevity genes. (2006) (75)
- SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis (2017) (74)
- Subunit interaction in the CCAAT-binding heteromeric complex is mediated by a very short alpha-helix in HAP2. (1994) (73)
- SirT1 is required in the male germ cell for differentiation and fecundity in mice (2014) (73)
- Constitutive expression of the yeast HEM1 gene is actually a composite of activation and repression. (1987) (72)
- Increased dosage of a transcriptional activator gene enhances iron-limited growth of Saccharomyces cerevisiae. (1992) (71)
- Dietary restriction: standing up for sirtuins. (2010) (70)
- Urea cycle regulation by mitochondrial sirtuin, SIRT5 (2009) (70)
- Deviation of innate circadian period from 24 h reduces longevity in mice (2012) (69)
- Tissue-specific regulation of SIRT 1 by calorie restriction (2008) (66)
- Transcription by RNA polymerase II induces changes of DNA topology in yeast. (1988) (66)
- Strategies for the identification of interacting proteins. (1993) (66)
- Separation of mother and daughter cells. (2002) (64)
- The Schizosaccharomyces pombe homolog of Saccharomyces cerevisiae HAP2 reveals selective and stringent conservation of the small essential core protein domain (1991) (63)
- SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. (2013) (62)
- Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity. (2002) (61)
- Science fact and the SENS agenda (2005) (61)
- Unlocking the secrets of longevity genes (2006) (60)
- Conservation and evolution of transcriptional mechanisms in eukaryotes. (1992) (59)
- Organization of the regulatory region of the yeast CYC7 gene: multiple factors are involved in regulation (1987) (59)
- Metabolic changes in Saccharomyces cerevisiae strains lacking citrate synthases. (1988) (58)
- HAP1 is nuclear but is bound to a cellular factor in the absence of heme. (1994) (58)
- Do Changes in Chromosomes Cause Aging? (1996) (57)
- Open reading frame cloning: identification, cloning, and expression of open reading frame DNA. (1982) (57)
- Acute Oxidative Stress Can Reverse Insulin Resistance by Inactivation of Cytoplasmic JNK* (2010) (57)
- Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism. (2004) (56)
- Genetic Fusions of the lac Operon: A New Approach to the Study of Biological Processes (1980) (56)
- Mutant RNA polymerase of Escherichia coli terminates transcription in strains making defective rho factor. (1978) (56)
- Identification of a yeast protein homologous in function to the mammalian general transcription factor, TFIIA. (1989) (55)
- Evidence for BLM and Topoisomerase IIIalpha interaction in genomic stability. (2001) (55)
- Aging Research—Where Do We Stand and Where Are We Going? (2014) (53)
- Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae. (1997) (52)
- SIRT 5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle Citation (52)
- DEP domain–containing mTOR–interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute‐on‐chronic liver injury in alcoholic liver disease (2018) (52)
- Mutational analysis of a yeast transcriptional terminator. (1989) (52)
- SIR2 and aging--the exception that proves the rule. (2001) (51)
- SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2 (2017) (51)
- Sirt 1 mediates neuroprotection from mutant huntingtin by activation of the TORC 1 and CREB transcriptional pathway Citation (2012) (50)
- Neurogenesis directed by Sirt1 (2008) (49)
- SnapShot: sirtuins, NAD, and aging. (2014) (48)
- Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled human pilot study (2019) (48)
- HAP1 positive control mutants specific for one of two binding sites. (1992) (47)
- The place of genetics in ageing research (2012) (47)
- In vitro construction and characterization of phoA-lacZ gene fusions in Escherichia coli (1983) (47)
- What Makes Us Tick? (1997) (45)
- Aging, life span, and senescence. (1998) (45)
- Evidence that TUP1/SSN6 has a positive effect on the activity of the yeast activator HAP1. (1994) (44)
- Transcription termination at the end of the tryptophan operon of Escherichia coli. (1977) (44)
- Human genetics: Testing telomerase (2001) (44)
- by two different mechanisms Saccharomyces cerevisiae alone promote longevity in SIR 2 complex and SIR 2 / 3 / 4 The (1999) (43)
- SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kγ Activity through Deacetylation of Specific Lysine Residues in Mammals (2010) (42)
- Mutations that alter transcriptional activation but not DNA binding in the zinc finger of yeast activator HAPI (1989) (41)
- The nine amino-terminal residues of delta-aminolevulinate synthase direct beta-galactosidase into the mitochondrial matrix (1986) (41)
- Antibody-promoted dimerization bypasses the regulation of DNA binding by the heme domain of the yeast transcriptional activator HAP1. (1993) (41)
- SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin (2013) (40)
- The C6 zinc cluster dictates asymmetric binding by HAP1. (1996) (40)
- Life-Span Extension in Yeast (2006) (40)
- Genetic selection for genes encoding sequence-specific DNA-binding proteins. (1989) (39)
- Using yeast to discover the fountain of youth. (2001) (38)
- A technique for expressing eukaryotic genes in bacteria. (1980) (37)
- Mutational analysis of a yeast transcriptional terminator (1989) (36)
- SIRT 1 Suppresses b-Amyloid Production by Activating the a-Secretase Gene ADAM 10 (2010) (35)
- 3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1 (2010) (34)
- The Many Faces of Sirtuins: Sirtuins and the Warburg effect (2014) (33)
- A single Saccharomyces cerevisiae upstream activation site (UAS1) has two distinct regions essential for its activity (1986) (33)
- Genetic analysis of aging in Saccharomyces cerevisiae. (1996) (32)
- Introduction: sirtuins in aging and diseases. (2013) (32)
- Mechanisms of cellular senescence. (1997) (31)
- Linking DNA damage, NAD(+)/SIRT1, and aging. (2014) (31)
- Science fact and the SENS agenda. What can we reasonably expect from ageing research? (2005) (31)
- Retraction Notice to: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10 (2014) (30)
- Sirtuin 1 Promotes Deacetylation of Oct4 and Maintenance of Naive Pluripotency. (2016) (28)
- The resurgence of NAD+ (2016) (28)
- Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic ß Cells (2006) (27)
- Deletions of distal sequence affect termination of transcription at the end of the tryptophan operon in E. coli (1980) (27)
- SIRT1 deacetylase in aging‐induced neuromuscular degeneration and amyotrophic lateral sclerosis (2018) (26)
- Cloning the gene for Werner syndrome: a disease with many symptoms of premature aging. (1996) (26)
- Vicious circles: a mechanism for yeast aging. (1998) (25)
- Structure of HAP1-18–DNA implicates direct allosteric effect of protein–DNA interactions on transcriptional activation (1999) (24)
- Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging (2019) (23)
- Functional Specialization in Rhesus Monkey Auditory Cortex (2001) (23)
- N-terminal deletions of a mitochondrial signal sequence in yeast. Targeting information of delta-aminolevulinate synthase is encoded in non-overlapping regions. (1989) (22)
- Restoration of termination by RNA polymerase mutations is rho allele-specific. (1979) (22)
- Conferral of transposable properties to a chromosomal gene in Escherichia coli. (1980) (21)
- Sirtuins and calorie restriction (2012) (20)
- Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells (2015) (20)
- Cassette for the generation of sequential gene disruptions in the yeast Schizosaccharomyces pombe. (1997) (20)
- Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI (2020) (19)
- Structure of the malB region in Escherichia coli K12 (1979) (19)
- Two or more copies of Drosophila heat shock consensus sequence serve to activate transcription in yeast. (1986) (19)
- Internal deletions in the yeast transcriptional activator HAP1 have opposite effects at two sequence elements. (1990) (19)
- Ageless quest : one scientist's search for genes that prolong youth (2003) (17)
- The untranslated leader of nuclear COX4 gene of Saccharomyces cerevisiae contains an intron. (1987) (17)
- Ageing: Mutant mice live longer (1999) (17)
- Impairment of an Endothelial NAD +-H 2 S Signaling Network Is a Reversible Cause of Vascular Aging Graphical Abstract Highlights (2018) (17)
- Muscle-Specific SIRT 1 Gain-of-Function Increases Slow-Twitch Fibers and Ameliorates Pathophysiology in a Mouse Model of Duchenne Muscular Dystrophy (2014) (17)
- Revelations into resveratrol's mechanism (2012) (16)
- 2 Sirtuins: A Universal Link between NAD, Metabolism, and Aging (2008) (16)
- ADA3: a gene, identified by resistance to GAL4-VP16, with properties similar to and different from those of ADA2 (1993) (16)
- Genetic and biochemical probes for protein-protein interactions. (1996) (16)
- Sirtuins and β‐cell function (2007) (15)
- The Nine Amino-Terminal Residues of 8-Aminolevulinate Synthase Direct 1-Galactosidase into the Mitochondrial Matrix (15)
- The unexpected role of mTORC1 in intestinal stem cells during calorie restriction (2017) (15)
- Biochemistry Silencing and Aging (The Sir2 Family of Protein Acetyltransferases) (2003) (15)
- 2 Messenger RNA Transcription and Its Control in Saccharomyces cerevisiae (1992) (15)
- Hypoxic Hookup (2009) (14)
- Metabolic signals regulate SIRT1 expression (2011) (13)
- A mutation distal to the messenger RNA endpoint reduces transcription termination in the tryptophan operon in Escherichia coli. (1979) (12)
- Saccharomyces cerevisiae SSD 1V Confers Longevity by a Sir 2 p-Independent Mechanism (2004) (12)
- Sirtuins and ageing—new findings (2013) (12)
- The acidic transcriptional activation domains of herpes virus VP16 and yeast HAP4 have different co-factor requirements. (1995) (11)
- 38 Mechanism and Regulation of Transcriptional Activation in Eukaryotes: Conserved Features from Yeasts to Humans (1992) (11)
- Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice (2017) (11)
- Corrigendum to SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin [EMBO Mol Med] DOI: 10.1002/emmm.201201606 (2013) (11)
- NO link between calorie restriction and mitochondria (2005) (10)
- Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer’s disease (2019) (10)
- The overproducing CYP1 and the underproducing hap1 mutations are alleles of the same gene which regulates in trans the expression of the structural genes encoding iso-cytochromes c (2004) (9)
- corrigendum: Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ (2004) (9)
- Myeloid Cell Sirtuin-1 Expression Does Not Alter Host Immune Responses to Gram-Negative Endotoxemia or Gram-Positive Bacterial Infection (2013) (8)
- The Longevity Gene SIRT-1 Independently Controls Both Osteoblast and Osteoclast Function (2008) (8)
- Aging. What makes us tick? (1997) (7)
- SIRT 1 is a positive regulator of the master osteoblast transcription factor , RUNX 2 (2017) (7)
- The aging associated gene SIRT-1 regulates osteoclast formation and bone mass in vivo (2007) (7)
- Overcoming ATM Deficiency by Activating the NAD+/SIRT1 Axis. (2016) (7)
- Connecting the Dots: Linking Sirtuins and AMPK in Metabolism and Aging (2011) (7)
- THE ROLE OF HEME AND OXYGEN IN THE REGULATION OF MITOCHONDRIAL CYTOCHROMES (1983) (6)
- Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment. (2017) (6)
- Multiple domains mediate heme control of the yeast activator HAP1 (1995) (6)
- Use of Gene Fusions to Study Biological Problems (1984) (6)
- Safety Assessment of High-Purity, Synthetic Nicotinamide Riboside (NR-E) in a 90-Day Repeated Dose Oral Toxicity Study, With a 28-Day Recovery Arm (2020) (6)
- Forestalling the Great Beyond with the Help of SIR2 (2004) (5)
- Calorie Restriction Prevents Age-Related Trabecular Bone Loss via SIRT (2008) (5)
- The nuts and bolts of biotechnology Genetic engineering 4. Edited by R. Williamson New York: Academic Press. (1983). 185 pp. $22.00 (1983) (5)
- Chromatin and ageing in yeast and in mammals. (1997) (4)
- Aging and Rejuvenation: Insights from Rusty Gage, Leonard Guarente, and Amy Wagers. (2016) (4)
- Advances in Brief Nijmegen Breakage Syndrome Disease Protein and MRE 11 at PML Nuclear Bodies and Meiotic Telomeres 1 (2000) (4)
- Sirtuins, NAD + , Aging, and Disease (2018) (4)
- DEPTOR Suppresses Lipogenesis and Ameliorates Hepatic Steatosis and Acute-on-Chronic Liver Injury in Alcoholic Liver Disease Short Title — Defective Signaling of SIRT 1 and DEPTOR Contributes to Alcoholic Liver Disease in Mice and Humans (2018) (3)
- 31 – Protocol for High-Efficiency Yeast Transformation (1991) (3)
- SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5K[subscript gamma] Activity through Deacetylation of Specific Lysine Residues in Mammals (2010) (2)
- Author Correction: Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study (2018) (2)
- Sirtuins, aging and diseases (2012) (2)
- 4-Phenylbutyrate restores localization and membrane repair to human dysferlin mutations (2021) (2)
- Retraction Notice to: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10. (2014) (1)
- STRUCTURE OF A HAP1-18/DNA COMPLEX REVEALS THAT PROTEIN/DNA INTERACTIONS CAN HAVE DIRECT ALLOSTERIC EFFECTS ON TRANSCRIPTIONAL ACTIVATION (1999) (1)
- ATechnique forExpressing Eukaryotic GenesinBacteria (1980) (1)
- Bordone, L. et al. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 6, 759-767 (2008) (1)
- The aging associated gene SIRT-1 controls bone mass in vivo through osteoblast and osteoclast regulation (2008) (1)
- Regulation of the yeast CYC1 gene. (1986) (1)
- Acetylation, Activation, and Toxicity: The Role of ADA/GCN5 Complex in Transcription (1997) (1)
- SIR2 Proteins Regulate Aging in Response to Nutrients (2001) (1)
- pombeHomologofSaccharomyces cerevisiae HAP2Reveals Selective andStringent Conservation of theSmallEssential CoreProtein Domain (1991) (0)
- Yeast ADA 2 protein binds to the VP 16 protein activation domain and activates transcription ( transcriptional adaptor / coactlvators ) (0)
- Nuclear Chromatin Factors Defining Mitochondrial Bioenergetics (2012) (0)
- A Genetic Approach to the Study of Iron Metabolism in Saccharomyces Cerevisiae (1991) (0)
- To what extent is ageing genetic ? (2012) (0)
- Nucleus and gene expression. (2000) (0)
- Advisory Board and Contents (2020) (0)
- Abstract SY09-02: Can sitruin activation treat cancer (2010) (0)
- A Distinct Signaling Pathway Used by the IgG-Containing B Cell Antigen Receptor (2002) (0)
- Preface/Front Matter (2008) (0)
- Regulation oftheYeastCYTIGeneEncoding Cytochrome cl byHAP1andHAP2/3/4 (1991) (0)
- Leonard Guarente by two different mechanismsSaccharomyces cerevisiae alone promote longevity in SIR 2 complex and SIR 2 / 3 / 4 The (1999) (0)
- NRPT reduces markers of hepatic inflammation in non-alcoholic fatty liver disease: a double-blind, placebo-controlled clinical trial. (2022) (0)
- regulatory complex cholesterol SIRT1 and LXR and methods of use. (2007) (0)
- Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study (2017) (0)
- A GALJO-CYCJ hybrid yeast promoter identifies-the GAL 4 regulatory region as an upstream site ( yeast promoter structure / gilactose induction / glucose repression / upstream activation sites / inducer exclusion ) (0)
- Molten rocks in motion (1999) (0)
- optimal production of polypeptides (1981) (0)
- Author Correction: Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study (2018) (0)
- The [NAD[superscript +] over Sirtuin] Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling (2013) (0)
- Abstracts of papers presented at the 1998 Meeting on Genetics of Aging, April 2 - April 5, 1998 (1998) (0)
- Investigate the Role of Obesity in Ovarian Cancer Initiation and Progression (2016) (0)
- Unglycosylated human fibroblast interferon and a method for manufacturing the same (1981) (0)
- Telomere dysfunction cooperates with Werner deficiency to promote premature aging and cancer in mice (2005) (0)
- ADA3:aGene,Identified byResistance toGAL4-VP16, with Properties Similar toandDifferent fromThoseofADA2 (1993) (0)
- In Brief (2000) (0)
- Supplemental Information Mutations that Allow SIR 2 Orthologs to Function in a NAD +-Depleted Environment (2017) (0)
- Advisory Board and Contents (2020) (0)
- Sirtuin 1 Attenuates Pulmonary Neutrophilic Inflammation In Mice Exposed To Cigarette Smoke (2011) (0)
- Correction: SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington’s Disease Phenotypes In Vivo (2021) (0)
- SIRT1 Promotes Differentiation of Normal Human (2009) (0)
- Forever Young (2010) (0)
- Isolation of the gene encoding the yeast TATA binding TFIID: a gene identical to the SPT15 suppressor of Ty element insertions (1989) (0)
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What Schools Are Affiliated With Leonard P Guarente?
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