Leonard P Guarente

Leonard P Guarente's AcademicInfluence.com Rankings

Leonard P Guarente

Biology

#2942

World Rank

#4581

Historical Rank

Molecular Biology

#187

World Rank

#191

Historical Rank

Genetics

#201

World Rank

#245

Historical Rank

biology Degrees

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Biology

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Leonard P Guarente's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase (2000) (3230)
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase (2001) (2479)
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. (1999) (2145)
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ (2004) (1934)
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans (2001) (1931)
Negative Control of p53 by Sir2α Promotes Cell Survival under Stress (2001) (1877)
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. (2000) (1803)
The Sir2 family of protein deacetylases. (2004) (1532)
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia (2011) (1502)
Extrachromosomal rDNA Circles— A Cause of Aging in Yeast (1997) (1435)
Mammalian SIRT1 Represses Forkhead Transcription Factors (2004) (1400)
Genetic pathways that regulate ageing in model organisms (2000) (1318)
The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control (2008) (1282)
Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. (2006) (1274)
Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6 (2006) (1229)
Negative control of p53 by Sir2alpha promotes cell survival under stress. (2001) (1145)
Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation (2007) (1116)
SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells (2006) (1084)
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration (2002) (1059)
Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast. (1983) (1005)
Calorie restriction, SIRT1 and metabolism: understanding longevity (2005) (978)
The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling (2013) (917)
NAD+ and sirtuins in aging and disease. (2014) (877)
Five intermediate complexes in transcription initiation by RNA polymerase II (1989) (863)
Calorie Restriction— the SIR2 Connection (2005) (793)
SIRT1 and other sirtuins in metabolism (2014) (776)
High-efficiency transformation of yeast by electroporation. (1991) (742)
SIRT1 transgenic mice show phenotypes resembling calorie restriction (2007) (717)
Sir2 links chromatin silencing, metabolism, and aging. (2000) (713)
Molecular Biology of Aging (1999) (697)
Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells (2005) (695)
Calorie restriction extends yeast life span by lowering the level of NADH. (2004) (646)
SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle (2009) (640)
Two neurons mediate diet-restriction-induced longevity in C. elegans (2007) (633)
SIRT1 deacetylates and positively regulates the nuclear receptor LXR. (2007) (622)
The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth (2008) (606)
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. (2006) (583)
Tissue-specific regulation of SIRT1 by calorie restriction. (2008) (547)
Mouse Sir2 Homolog SIRT6 Is a Nuclear ADP-ribosyltransferase* (2005) (541)
Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site (1983) (533)
A Fasting Inducible Switch Modulates Gluconeogenesis Via Activator-Coactivator Exchange (2008) (513)
Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins? (2008) (502)
How does calorie restriction work? (2003) (489)
SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging (2013) (487)
Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae (1995) (482)
A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site. (1982) (464)
Essential role of limiting telomeres in the pathogenesis of Werner syndrome (2004) (450)
Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. (2003) (444)
Genetics and the Specificity of the Aging Process (2003) (442)
Increase in Activity During Calorie Restriction Requires Sirt1 (2005) (438)
Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains (1992) (436)
Sirtuins as potential targets for metabolic syndrome (2006) (435)
A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span. (2005) (428)
Franklin H. Epstein Lecture: Sirtuins, aging, and medicine. (2011) (423)
Genetic links between diet and lifespan: shared mechanisms from yeast to humans (2007) (420)
SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production (2011) (417)
Fusion of Escherichia coli lacZ to the cytochrome c gene of Saccharomyces cerevisiae. (1981) (407)
Distinctly regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of S. cerevisiae (1984) (395)
Identification and characterization of HAP4: a third component of the CCAAT-bound HAP2/HAP3 heteromer. (1989) (394)
Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. (1997) (393)
Elimination of replication block protein Fob1 extends the life span of yeast mother cells. (1999) (390)
Calorie restriction and sirtuins revisited (2013) (389)
Redistribution of Silencing Proteins from Telomeres to the Nucleolus Is Associated with Extension of Life Span in S. cerevisiae (1997) (388)
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. (2010) (379)
C. elegans SIR-2.1 Interacts with 14-3-3 Proteins to Activate DAF-16 and Extend Life Span (2006) (375)
The multifaceted functions of sirtuins in cancer (2015) (346)
SIRTUINS, AGING AND DISEASE (2010) (345)
Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes (2013) (344)
SIRT1 in Neurodevelopment and Brain Senescence (2014) (341)
MEC1-Dependent Redistribution of the Sir3 Silencing Protein from Telomeres to DNA Double-Strand Breaks (1999) (333)
RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10 (2010) (327)
Sirt1 mediates neuroprotection from mutant huntingtin by activation of TORC1 and CREB transcriptional pathway (2011) (327)
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. (2012) (319)
High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction. (2012) (314)
Aging and disease: connections to sirtuins (2010) (308)
Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span (1994) (304)
Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells (2013) (301)
Sirtuins mediate mammalian metabolic responses to nutrient availability (2012) (301)
Cloning of yeast HAP5: a novel subunit of a heterotrimeric complex required for CCAAT binding. (1995) (288)
Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors. (1994) (287)
Loss of Transcriptional Silencing Causes Sterility in Old Mother Cells of S. cerevisiae (1996) (286)
Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver (2011) (286)
Functional dissection and sequence of yeast HAP1 activator (1989) (282)
Heme binds to a short sequence that serves a regulatory function in diverse proteins. (1995) (279)
Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging (2018) (277)
Sirtuins at a glance (2011) (271)
Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: Evidence for transcriptional adaptors (1990) (269)
Function of a yeast TATA element-binding protein in a mammalian transcription system (1988) (268)
Each of three "TATA elements" specifies a subset of the transcription initiation sites at the CYC-1 promoter of Saccharomyces cerevisiae. (1985) (264)
The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase (2001) (263)
It takes two to tango: NAD+ and sirtuins in aging/longevity control (2016) (259)
Synthetic enhancement in gene interaction: a genetic tool come of age. (1993) (248)
Proteolipid Protein Is Required for Transport of Sirtuin 2 into CNS Myelin (2007) (242)
Yeast TATA-binding protein TFIID binds to TATA elements with both consensus and nonconsensus DNA sequences. (1989) (236)
Yeast HAP1 activator binds to two upstream activation sites of different sequence (1987) (229)
Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. (2014) (227)
SIRT1 Inhibits Transforming Growth Factor β-Induced Apoptosis in Glomerular Mesangial Cells via Smad7 Deacetylation* (2007) (220)
Nucleolar localization of the Werner syndrome protein in human cells. (1998) (214)
Telomere Shortening Exposes Functions for the Mouse Werner and Bloom Syndrome Genes (2004) (211)
The SirT3 divining rod points to oxidative stress. (2011) (208)
Isolation of the gene encoding the yeast TATA binding protein TFIID: A gene identical to the SPT15 suppressor of Ty element insertions (1989) (205)
A yeast and a human CCAAT-binding protein have heterologous subunits that are functionally interchangeable (1988) (205)
mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction (2016) (204)
Nuclear structure in normal and Bloom syndrome cells. (2000) (201)
Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. (2013) (198)
Yeast HAP2 and HAP3 activators both bind to the CYC1 upstream activation site, UAS2, in an interdependent manner (1987) (198)
SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive (2011) (195)
Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes (2011) (195)
SIR2: a potential target for calorie restriction mimetics. (2007) (192)
Small-molecule allosteric activators of sirtuins. (2013) (191)
The HAP2 subunit of yeast CCAAT transcriptional activator contains adjacent domains for subunit association and DNA recognition: model for the HAP2/3/4 complex. (1990) (190)
A cDNA encoding a human CCAAT-binding protein cloned by functional complementation in yeast. (1991) (189)
SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones (2012) (189)
Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction. (2009) (185)
A therapeutic role for sirtuins in diseases of aging? (2007) (184)
SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin (2013) (183)
Improved methods for maximizing expression of a cloned gene: a bacterium that synthesizes rabbit β-globin (1980) (183)
Sirtuin deacetylases in neurodegenerative diseases of aging (2013) (182)
ADA3, a putative transcriptional adaptor, consists of two separable domains and interacts with ADA2 and GCN5 in a trimeric complex (1995) (181)
Sirtuins, aging, and metabolism. (2011) (181)
Aging in Saccharomyces cerevisiae. (1998) (178)
Mutations in the WRN Gene in Mice Accelerate Mortality in a p53-Null Background (2000) (176)
Superoxide Dismutase 1 Knock-down Induces Senescence in Human Fibroblasts* (2003) (176)
SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis. (2013) (176)
Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells. (2000) (175)
Calorie restriction and SIR2 genes—Towards a mechanism (2005) (172)
Communication between mitochondria and the nucleus in regulation of cytochrome genes in the yeast Saccharomyces cerevisiae. (1989) (167)
Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae. (1999) (165)
Mutations in yeast HAP2/HAP3 define a hybrid CCAAT box binding domain. (1993) (159)
Effects of Mutations in DNA Repair Genes on Formation of Ribosomal DNA Circles and Life Span inSaccharomyces cerevisiae (1999) (159)
Diverse and dynamic functions of the Sir silencing complex (1999) (158)
Yeast HAP1 activator competes with the factor RC2 for binding to the upstream activation site UAS1 of the CYC1 gene (1987) (157)
Yeast promoters: Positive and negative elements (1984) (152)
UASs and enhancers: Common mechanism of transcriptional activation in yeast and mammals (1988) (150)
Sir2: an NAD-dependent histone deacetylase that connects chromatin silencing, metabolism, and aging. (2000) (150)
Upstream activation sites of the CYC1 gene of Saccharomyces cerevisiae are active when inverted but not when placed downstream of the "TATA box". (1984) (148)
Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria. (2004) (148)
Transcriptional coactivators in yeast and beyond. (1995) (145)
Saccharomyces cerevisiae contains two functional citrate synthase genes (1986) (143)
High Osmolarity Extends Life Span in Saccharomyces cerevisiae by a Mechanism Related to Calorie Restriction (2002) (142)
SIRT1 Suppresses b-Amyloid Production by Activating the a-Secretase Gene ADAM10 (2010) (141)
Vectors for expression of cloned genes in yeast: regulation, overproduction, and underproduction. (1991) (137)
Regulatory proteins in yeast. (1987) (135)
Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres. (2000) (135)
Model organisms as a guide to mammalian aging. (2002) (133)
Saccharomyces cerevisiae MPT5 and SSD1 function in parallel pathways to promote cell wall integrity. (2002) (133)
Striking conservation of TFIID in Schizosaccharomyces pombe and Saccharomyces cerevisiae (1990) (132)
Cloning and molecular analysis of the HAP2 locus: a global regulator of respiratory genes in Saccharomyces cerevisiae (1985) (130)
SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo (2012) (128)
Yeast HAP2 and HAP3: transcriptional activators in a heteromeric complex. (1988) (123)
Sequence and nuclear localization of the Saccharomyces cerevisiae HAP2 protein, a transcriptional activator (1987) (121)
Molecular mechanisms of yeast aging. (1998) (121)
The brain, sirtuins, and ageing (2017) (120)
Yeast ADA2 protein binds to the VP16 protein activation domain and activates transcription. (1994) (117)
Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study (2017) (117)
ADA3: a gene, identified by resistance to GAL4-VP16, with properties similar to and different from those of ADA2. (1993) (116)
Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co‐activator PC4. (1996) (116)
Isolation, sequence, and regulation by oxygen of the yeast HEM13 gene coding for coproporphyrinogen oxidase. (1988) (113)
Mutational analysis of upstream activation sequence 2 of the CYC1 gene of Saccharomyces cerevisiae: a HAP2-HAP3-responsive site (1988) (113)
The HAP3 regulatory locus of Saccharomyces cerevisiae encodes divergent overlapping transcripts (1988) (113)
Evidence for BLM and Topoisomerase IIIα interaction in genomic stability (2001) (112)
SIRT1 promotes differentiation of normal human keratinocytes. (2009) (111)
Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c–SIRT2 axis (2017) (109)
Molecular links between aging and adipose tissue (2005) (109)
ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3 (1997) (107)
A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. (2000) (106)
Link between aging and the nucleolus. (1997) (105)
Mitochondrial and nonmitochondrial citrate synthases in Saccharomyces cerevisiae are encoded by distinct homologous genes (1986) (102)
The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination. (2001) (102)
ADA5/SPT20 links the ADA and SPT genes, which are involved in yeast transcription (1996) (100)
Roles of SIRT1 in the Acute and Restorative Phases following Induction of Inflammation* (2010) (97)
SIRT1-mediated acute cardioprotection. (2011) (95)
Muscle-Specific SIRT1 Gain-of-Function Increases Slow-Twitch Fibers and Ameliorates Pathophysiology in a Mouse Model of Duchenne Muscular Dystrophy (2014) (93)
The yeast activator HAP1--a GAL4 family member--binds DNA in a directly repeated orientation. (1994) (91)
Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota. (2017) (90)
Expression of the human fibroblast interferon gene in Escherichia coli. (1980) (89)
The Saccharomyces cerevisiae Hap5p homolog from fission yeast reveals two conserved domains that are essential for assembly of heterotetrameric CCAAT-binding factor (1997) (88)
Increased Life Span due to Calorie Restriction in Respiratory-Deficient Yeast (2006) (85)
NAD+ supplementation rejuvenates aged gut adult stem cells (2019) (85)
SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism. (2014) (83)
Dyskeratosis congenita, telomeres and human ageing. (2000) (83)
Regulation of the yeast CYT1 gene encoding cytochrome c1 by HAP1 and HAP2/3/4 (1991) (83)
Telomeres, the nucleolus and aging. (1998) (82)
Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway (2016) (81)
Mutant lambda phage repressor with a specific defect in its positive control function. (1982) (81)
Sirtuins, Aging, and Medicine (2011) (80)
A novel telomere structure in a human alternative lengthening of telomeres cell line. (2005) (79)
Structure of a HAP1–DNA complex reveals dramatically asymmetric DNA binding by a homodimeric protein (1999) (79)
The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration (2008) (77)
SIRT1 Shows No Substrate Specificity in Vitro* (2005) (77)
The logic linking protein acetylation and metabolism. (2011) (76)
Metabolic and neuropsychiatric effects of calorie restriction and sirtuins. (2013) (75)
Unlocking the secrets of longevity genes. (2006) (75)
SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis (2017) (74)
Subunit interaction in the CCAAT-binding heteromeric complex is mediated by a very short alpha-helix in HAP2. (1994) (73)
SirT1 is required in the male germ cell for differentiation and fecundity in mice (2014) (73)
Constitutive expression of the yeast HEM1 gene is actually a composite of activation and repression. (1987) (72)
Increased dosage of a transcriptional activator gene enhances iron-limited growth of Saccharomyces cerevisiae. (1992) (71)
Dietary restriction: standing up for sirtuins. (2010) (70)
Urea cycle regulation by mitochondrial sirtuin, SIRT5 (2009) (70)
Deviation of innate circadian period from 24 h reduces longevity in mice (2012) (69)
Tissue-specific regulation of SIRT 1 by calorie restriction (2008) (66)
Transcription by RNA polymerase II induces changes of DNA topology in yeast. (1988) (66)
Strategies for the identification of interacting proteins. (1993) (66)
Separation of mother and daughter cells. (2002) (64)
The Schizosaccharomyces pombe homolog of Saccharomyces cerevisiae HAP2 reveals selective and stringent conservation of the small essential core protein domain (1991) (63)
SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. (2013) (62)
Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity. (2002) (61)
Science fact and the SENS agenda (2005) (61)
Unlocking the secrets of longevity genes (2006) (60)
Conservation and evolution of transcriptional mechanisms in eukaryotes. (1992) (59)
Organization of the regulatory region of the yeast CYC7 gene: multiple factors are involved in regulation (1987) (59)
Metabolic changes in Saccharomyces cerevisiae strains lacking citrate synthases. (1988) (58)
HAP1 is nuclear but is bound to a cellular factor in the absence of heme. (1994) (58)
Do Changes in Chromosomes Cause Aging? (1996) (57)
Open reading frame cloning: identification, cloning, and expression of open reading frame DNA. (1982) (57)
Acute Oxidative Stress Can Reverse Insulin Resistance by Inactivation of Cytoplasmic JNK* (2010) (57)
Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism. (2004) (56)
Genetic Fusions of the lac Operon: A New Approach to the Study of Biological Processes (1980) (56)
Mutant RNA polymerase of Escherichia coli terminates transcription in strains making defective rho factor. (1978) (56)
Identification of a yeast protein homologous in function to the mammalian general transcription factor, TFIIA. (1989) (55)
Evidence for BLM and Topoisomerase IIIalpha interaction in genomic stability. (2001) (55)
Aging Research—Where Do We Stand and Where Are We Going? (2014) (53)
Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae. (1997) (52)
SIRT 5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle Citation (52)
DEP domain–containing mTOR–interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute‐on‐chronic liver injury in alcoholic liver disease (2018) (52)
Mutational analysis of a yeast transcriptional terminator. (1989) (52)
SIR2 and aging--the exception that proves the rule. (2001) (51)
SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2 (2017) (51)
Sirt 1 mediates neuroprotection from mutant huntingtin by activation of the TORC 1 and CREB transcriptional pathway Citation (2012) (50)
Neurogenesis directed by Sirt1 (2008) (49)
SnapShot: sirtuins, NAD, and aging. (2014) (48)
Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled human pilot study (2019) (48)
HAP1 positive control mutants specific for one of two binding sites. (1992) (47)
The place of genetics in ageing research (2012) (47)
In vitro construction and characterization of phoA-lacZ gene fusions in Escherichia coli (1983) (47)
What Makes Us Tick? (1997) (45)
Aging, life span, and senescence. (1998) (45)
Evidence that TUP1/SSN6 has a positive effect on the activity of the yeast activator HAP1. (1994) (44)
Transcription termination at the end of the tryptophan operon of Escherichia coli. (1977) (44)
Human genetics: Testing telomerase (2001) (44)
by two different mechanisms Saccharomyces cerevisiae alone promote longevity in SIR 2 complex and SIR 2 / 3 / 4 The (1999) (43)
SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kγ Activity through Deacetylation of Specific Lysine Residues in Mammals (2010) (42)
Mutations that alter transcriptional activation but not DNA binding in the zinc finger of yeast activator HAPI (1989) (41)
The nine amino-terminal residues of delta-aminolevulinate synthase direct beta-galactosidase into the mitochondrial matrix (1986) (41)
Antibody-promoted dimerization bypasses the regulation of DNA binding by the heme domain of the yeast transcriptional activator HAP1. (1993) (41)
SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin (2013) (40)
The C6 zinc cluster dictates asymmetric binding by HAP1. (1996) (40)
Life-Span Extension in Yeast (2006) (40)
Genetic selection for genes encoding sequence-specific DNA-binding proteins. (1989) (39)
Using yeast to discover the fountain of youth. (2001) (38)
A technique for expressing eukaryotic genes in bacteria. (1980) (37)
Mutational analysis of a yeast transcriptional terminator (1989) (36)
SIRT 1 Suppresses b-Amyloid Production by Activating the a-Secretase Gene ADAM 10 (2010) (35)
3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1 (2010) (34)
The Many Faces of Sirtuins: Sirtuins and the Warburg effect (2014) (33)
A single Saccharomyces cerevisiae upstream activation site (UAS1) has two distinct regions essential for its activity (1986) (33)
Genetic analysis of aging in Saccharomyces cerevisiae. (1996) (32)
Introduction: sirtuins in aging and diseases. (2013) (32)
Mechanisms of cellular senescence. (1997) (31)
Linking DNA damage, NAD(+)/SIRT1, and aging. (2014) (31)
Science fact and the SENS agenda. What can we reasonably expect from ageing research? (2005) (31)
Retraction Notice to: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10 (2014) (30)
Sirtuin 1 Promotes Deacetylation of Oct4 and Maintenance of Naive Pluripotency. (2016) (28)
The resurgence of NAD+ (2016) (28)
Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic ß Cells (2006) (27)
Deletions of distal sequence affect termination of transcription at the end of the tryptophan operon in E. coli (1980) (27)
SIRT1 deacetylase in aging‐induced neuromuscular degeneration and amyotrophic lateral sclerosis (2018) (26)
Cloning the gene for Werner syndrome: a disease with many symptoms of premature aging. (1996) (26)
Vicious circles: a mechanism for yeast aging. (1998) (25)
Structure of HAP1-18–DNA implicates direct allosteric effect of protein–DNA interactions on transcriptional activation (1999) (24)
Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging (2019) (23)
Functional Specialization in Rhesus Monkey Auditory Cortex (2001) (23)
N-terminal deletions of a mitochondrial signal sequence in yeast. Targeting information of delta-aminolevulinate synthase is encoded in non-overlapping regions. (1989) (22)
Restoration of termination by RNA polymerase mutations is rho allele-specific. (1979) (22)
Conferral of transposable properties to a chromosomal gene in Escherichia coli. (1980) (21)
Sirtuins and calorie restriction (2012) (20)
Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells (2015) (20)
Cassette for the generation of sequential gene disruptions in the yeast Schizosaccharomyces pombe. (1997) (20)
Nicotinamide riboside with pterostilbene (NRPT) increases NAD+ in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI (2020) (19)
Structure of the malB region in Escherichia coli K12 (1979) (19)
Two or more copies of Drosophila heat shock consensus sequence serve to activate transcription in yeast. (1986) (19)
Internal deletions in the yeast transcriptional activator HAP1 have opposite effects at two sequence elements. (1990) (19)
Ageless quest : one scientist's search for genes that prolong youth (2003) (17)
The untranslated leader of nuclear COX4 gene of Saccharomyces cerevisiae contains an intron. (1987) (17)
Ageing: Mutant mice live longer (1999) (17)
Impairment of an Endothelial NAD +-H 2 S Signaling Network Is a Reversible Cause of Vascular Aging Graphical Abstract Highlights (2018) (17)
Muscle-Specific SIRT 1 Gain-of-Function Increases Slow-Twitch Fibers and Ameliorates Pathophysiology in a Mouse Model of Duchenne Muscular Dystrophy (2014) (17)
Revelations into resveratrol's mechanism (2012) (16)
2 Sirtuins: A Universal Link between NAD, Metabolism, and Aging (2008) (16)
ADA3: a gene, identified by resistance to GAL4-VP16, with properties similar to and different from those of ADA2 (1993) (16)
Genetic and biochemical probes for protein-protein interactions. (1996) (16)
Sirtuins and β‐cell function (2007) (15)
The Nine Amino-Terminal Residues of 8-Aminolevulinate Synthase Direct 1-Galactosidase into the Mitochondrial Matrix (15)
The unexpected role of mTORC1 in intestinal stem cells during calorie restriction (2017) (15)
Biochemistry Silencing and Aging (The Sir2 Family of Protein Acetyltransferases) (2003) (15)
2 Messenger RNA Transcription and Its Control in Saccharomyces cerevisiae (1992) (15)
Hypoxic Hookup (2009) (14)
Metabolic signals regulate SIRT1 expression (2011) (13)
A mutation distal to the messenger RNA endpoint reduces transcription termination in the tryptophan operon in Escherichia coli. (1979) (12)
Saccharomyces cerevisiae SSD 1V Confers Longevity by a Sir 2 p-Independent Mechanism (2004) (12)
Sirtuins and ageing—new findings (2013) (12)
The acidic transcriptional activation domains of herpes virus VP16 and yeast HAP4 have different co-factor requirements. (1995) (11)
38 Mechanism and Regulation of Transcriptional Activation in Eukaryotes: Conserved Features from Yeasts to Humans (1992) (11)
Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice (2017) (11)
Corrigendum to SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin [EMBO Mol Med] DOI: 10.1002/emmm.201201606 (2013) (11)
NO link between calorie restriction and mitochondria (2005) (10)
Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer’s disease (2019) (10)
The overproducing CYP1 and the underproducing hap1 mutations are alleles of the same gene which regulates in trans the expression of the structural genes encoding iso-cytochromes c (2004) (9)
corrigendum: Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ (2004) (9)
Myeloid Cell Sirtuin-1 Expression Does Not Alter Host Immune Responses to Gram-Negative Endotoxemia or Gram-Positive Bacterial Infection (2013) (8)
The Longevity Gene SIRT-1 Independently Controls Both Osteoblast and Osteoclast Function (2008) (8)
Aging. What makes us tick? (1997) (7)
SIRT 1 is a positive regulator of the master osteoblast transcription factor , RUNX 2 (2017) (7)
The aging associated gene SIRT-1 regulates osteoclast formation and bone mass in vivo (2007) (7)
Overcoming ATM Deficiency by Activating the NAD+/SIRT1 Axis. (2016) (7)
Connecting the Dots: Linking Sirtuins and AMPK in Metabolism and Aging (2011) (7)
THE ROLE OF HEME AND OXYGEN IN THE REGULATION OF MITOCHONDRIAL CYTOCHROMES (1983) (6)
Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment. (2017) (6)
Multiple domains mediate heme control of the yeast activator HAP1 (1995) (6)
Use of Gene Fusions to Study Biological Problems (1984) (6)
Safety Assessment of High-Purity, Synthetic Nicotinamide Riboside (NR-E) in a 90-Day Repeated Dose Oral Toxicity Study, With a 28-Day Recovery Arm (2020) (6)
Forestalling the Great Beyond with the Help of SIR2 (2004) (5)
Calorie Restriction Prevents Age-Related Trabecular Bone Loss via SIRT (2008) (5)
The nuts and bolts of biotechnology Genetic engineering 4. Edited by R. Williamson New York: Academic Press. (1983). 185 pp. $22.00 (1983) (5)
Chromatin and ageing in yeast and in mammals. (1997) (4)
Aging and Rejuvenation: Insights from Rusty Gage, Leonard Guarente, and Amy Wagers. (2016) (4)
Advances in Brief Nijmegen Breakage Syndrome Disease Protein and MRE 11 at PML Nuclear Bodies and Meiotic Telomeres 1 (2000) (4)
Sirtuins, NAD + , Aging, and Disease (2018) (4)
DEPTOR Suppresses Lipogenesis and Ameliorates Hepatic Steatosis and Acute-on-Chronic Liver Injury in Alcoholic Liver Disease Short Title — Defective Signaling of SIRT 1 and DEPTOR Contributes to Alcoholic Liver Disease in Mice and Humans (2018) (3)
31 – Protocol for High-Efficiency Yeast Transformation (1991) (3)
SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5K[subscript gamma] Activity through Deacetylation of Specific Lysine Residues in Mammals (2010) (2)
Author Correction: Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study (2018) (2)
Sirtuins, aging and diseases (2012) (2)
4-Phenylbutyrate restores localization and membrane repair to human dysferlin mutations (2021) (2)
Retraction Notice to: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10. (2014) (1)
STRUCTURE OF A HAP1-18/DNA COMPLEX REVEALS THAT PROTEIN/DNA INTERACTIONS CAN HAVE DIRECT ALLOSTERIC EFFECTS ON TRANSCRIPTIONAL ACTIVATION (1999) (1)
ATechnique forExpressing Eukaryotic GenesinBacteria (1980) (1)
Bordone, L. et al. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 6, 759-767 (2008) (1)
The aging associated gene SIRT-1 controls bone mass in vivo through osteoblast and osteoclast regulation (2008) (1)
Regulation of the yeast CYC1 gene. (1986) (1)
Acetylation, Activation, and Toxicity: The Role of ADA/GCN5 Complex in Transcription (1997) (1)
SIR2 Proteins Regulate Aging in Response to Nutrients (2001) (1)
pombeHomologofSaccharomyces cerevisiae HAP2Reveals Selective andStringent Conservation of theSmallEssential CoreProtein Domain (1991) (0)
Yeast ADA 2 protein binds to the VP 16 protein activation domain and activates transcription ( transcriptional adaptor / coactlvators ) (0)
Nuclear Chromatin Factors Defining Mitochondrial Bioenergetics (2012) (0)
A Genetic Approach to the Study of Iron Metabolism in Saccharomyces Cerevisiae (1991) (0)
To what extent is ageing genetic ? (2012) (0)
Nucleus and gene expression. (2000) (0)
Advisory Board and Contents (2020) (0)
Abstract SY09-02: Can sitruin activation treat cancer (2010) (0)
A Distinct Signaling Pathway Used by the IgG-Containing B Cell Antigen Receptor (2002) (0)
Preface/Front Matter (2008) (0)
Regulation oftheYeastCYTIGeneEncoding Cytochrome cl byHAP1andHAP2/3/4 (1991) (0)
Leonard Guarente by two different mechanismsSaccharomyces cerevisiae alone promote longevity in SIR 2 complex and SIR 2 / 3 / 4 The (1999) (0)
NRPT reduces markers of hepatic inflammation in non-alcoholic fatty liver disease: a double-blind, placebo-controlled clinical trial. (2022) (0)
regulatory complex cholesterol SIRT1 and LXR and methods of use. (2007) (0)
Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study (2017) (0)
A GALJO-CYCJ hybrid yeast promoter identifies-the GAL 4 regulatory region as an upstream site ( yeast promoter structure / gilactose induction / glucose repression / upstream activation sites / inducer exclusion ) (0)
Molten rocks in motion (1999) (0)
optimal production of polypeptides (1981) (0)
Author Correction: Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study (2018) (0)
The [NAD[superscript +] over Sirtuin] Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling (2013) (0)
Abstracts of papers presented at the 1998 Meeting on Genetics of Aging, April 2 - April 5, 1998 (1998) (0)
Investigate the Role of Obesity in Ovarian Cancer Initiation and Progression (2016) (0)
Unglycosylated human fibroblast interferon and a method for manufacturing the same (1981) (0)
Telomere dysfunction cooperates with Werner deficiency to promote premature aging and cancer in mice (2005) (0)
ADA3:aGene,Identified byResistance toGAL4-VP16, with Properties Similar toandDifferent fromThoseofADA2 (1993) (0)
In Brief (2000) (0)
Supplemental Information Mutations that Allow SIR 2 Orthologs to Function in a NAD +-Depleted Environment (2017) (0)
Advisory Board and Contents (2020) (0)
Sirtuin 1 Attenuates Pulmonary Neutrophilic Inflammation In Mice Exposed To Cigarette Smoke (2011) (0)
Correction: SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington’s Disease Phenotypes In Vivo (2021) (0)
SIRT1 Promotes Differentiation of Normal Human (2009) (0)
Forever Young (2010) (0)
Isolation of the gene encoding the yeast TATA binding TFIID: a gene identical to the SPT15 suppressor of Ty element insertions (1989) (0)

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