Leonard R. Stephens
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British scientist
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Leonard R. Stephensmathematics Degrees
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Leonard R. Stephens's Degrees
- Masters Mathematics University of Oxford
- Bachelors Chemistry Imperial College London
Why Is Leonard R. Stephens Influential?
(Suggest an Edit or Addition)According to Wikipedia, Leonard R Stephens FRS is a molecular biologist, senior group leader and associate director at the Babraham Institute. Len Stephens has contributed much to the understanding of inositol lipids functions in eukaryotic cells, and in particular in neutrophils. Early highlights were the mapping of new pathways of inositol phosphate synthesis. Together with his long-time collaborator Phillip Thomas Hawkins, he established that PtdInsP2 is the main substrate of receptor-controlled Type 1 phosphoinositide 3-kinases , thus identifying PtdInsP3 as the key output signal produced by this enzyme. They identified and isolated the GPCR-activated Type 1B PI3K and, in a sustained body of work, defined its structure, explained its complex pattern of regulation by GβΥ and Ras, and proved its role in inflammatory events in vivo. They – in parallel with Dario Alessi – identified phosphoinositide-dependent kinase-1 as the PtdInsP3-activated link between PI3K-1 activation and protein kinase B activation, a key pathway through which PtdInsP3 formation regulates cell proliferation and survival. Later, they showed that PtdInsP3 was responsible for the recruitment of both PKB and PDK1 to the membrane, and therefore the activation of the former by the latter.
Leonard R. Stephens's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. (1997) (1251)
- Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. (2000) (1079)
- Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. (1998) (1063)
- PI3K signalling: the path to discovery and understanding (2012) (815)
- Signalling through Class I PI3Ks in mammalian cells. (2006) (592)
- PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase (1995) (553)
- A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits (1994) (544)
- The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101 (1997) (527)
- Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ (2000) (506)
- Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage (2013) (503)
- Structural insights into phosphoinositide 3-kinase catalysis and signalling (1999) (476)
- Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling (1994) (443)
- Activation of the small GTP-binding proteins rho and rac by growth factor receptors. (1995) (440)
- Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils (1991) (437)
- Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system? (1993) (437)
- PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox (2001) (410)
- Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B (1998) (389)
- PI3K signalling in inflammation. (2015) (361)
- Phosphoinositide 3‐kinase‐dependent activation of Rac (2003) (339)
- Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. (2005) (334)
- Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. (2002) (306)
- Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma. (2000) (295)
- The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate. (2001) (278)
- Roles of PI3Ks in leukocyte chemotaxis and phagocytosis. (2002) (273)
- Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry (2011) (252)
- P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. (2002) (240)
- The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. (1997) (232)
- Platelet-derived growth factor stimulates synthesis of Ptdlns(3,4,5)P3 by activating a Ptdlns(4,5)P2 3-OH kinase (1992) (227)
- SCFAs Induce Mouse Neutrophil Chemotaxis through the GPR43 Receptor (2011) (226)
- A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits. (1994) (204)
- Granulocyte macrophage‐colony stimulating factor stimulates both association and activation of phosphoinositide 3OH‐kinase and src‐related tyrosine kinase(s) in human myeloid derived cells. (1993) (199)
- The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s). (1993) (196)
- Neutrophils from p40phox−/− mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing (2006) (196)
- The PX domain: a new phosphoinositide-binding module. (2002) (189)
- P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-Regulated Guanine-Nucleotide Exchange Factor for Rac (2002) (187)
- Moving towards a Better Understanding of Chemotaxis (2008) (179)
- Phosphatidylinositol 3-phosphate is generated in phagosomal membranes (2001) (171)
- P-Rex1 Regulates Neutrophil Function (2005) (168)
- Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism (2011) (163)
- Receptor stimulated accumulation of phosphatidylinositol (3,4,5)‐trisphosphate by G‐protein mediated pathways in human myeloid derived cells. (1993) (161)
- p84, a New Gβγ-Activated Regulatory Subunit of the Type IB Phosphoinositide 3-Kinase p110γ (2005) (155)
- PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis. (2007) (148)
- PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis (2007) (147)
- Stepwise phosphorylation of myo-inositol leading to myo-inositol hexakisphosphate in Dictyostelium (1990) (146)
- Rapid formation of inositol 1,3,4,5-tetrakisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands may both result indirectly from receptor-stimulated release of inositol 1,4,5-trisphosphate from phosphatidylinositol 4,5-bisphosphate. (1986) (146)
- PtdIns3P binding to the PX domain of p40phox is a physiological signal in NADPH oxidase activation (2006) (139)
- PI3Kβ Plays a Critical Role in Neutrophil Activation by Immune Complexes (2011) (138)
- ARAP3 Is a PI3K- and Rap-Regulated GAP for RhoA (2004) (127)
- PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K (2017) (126)
- The cytotoxic T cell proteome and its shaping by mammalian Target of Rapamycin (2015) (122)
- Characterization of a phosphatidylinositol-specific phosphoinositide 3-kinase from mammalian cells (1994) (121)
- Phosphoinositide 3-kinases as drug targets in cancer. (2005) (116)
- FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. (2001) (110)
- Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ (2000) (109)
- Activation of Phosphoinositide 3-Kinase γ by Ras (2002) (108)
- Receptor specificity of growth factor-stimulated synthesis of 3-phosphorylated inositol lipids in Swiss 3T3 cells. (1992) (105)
- P‐Rex2, a new guanine‐nucleotide exchange factor for Rac (2004) (104)
- Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils. (2006) (103)
- PI3K signaling in neutrophils. (2010) (98)
- CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks. (2008) (95)
- Regulation of P-Rex1 by Phosphatidylinositol (3,4,5)-Trisphosphate and Gβγ Subunits* (2005) (95)
- Gβγs and the Ras binding domain of p110γ are both important regulators of PI3Kγ signalling in neutrophils (2006) (93)
- Emerging evidence of signalling roles for PI(3,4)P2 in Class I and II PI3K-regulated pathways. (2016) (88)
- myo-inositol pentakisphosphates. Structure, biological occurrence and phosphorylation to myo-inositol hexakisphosphate. (1991) (86)
- p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma. (2005) (84)
- Two distinct functions for PI3-kinases in macropinocytosis (2013) (81)
- PI3Kγ Is a Key Regulator of Inflammatory Responses and Cardiovascular Homeostasis (2007) (79)
- Regulation of Phosphatidylinositol 3-Kinase Activity and Phosphatidylinositol 3,4,5-Trisphosphate Accumulation by Neutrophil Priming Agents1 (2002) (74)
- Metabolic and structural evidence for the existence of a third species of polyphosphoinositide in cells: D-phosphatidyl-myo-inositol 3-phosphate. (1989) (72)
- Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy. (2018) (72)
- Synthesis of phosphatidylinositol 3,4,5-trisphosphate in permeabilized neutrophils regulated by receptors and G-proteins. (1993) (71)
- Phosphoinositide hydrolysis by guanosine 5'-[gamma-thio]triphosphate-activated phospholipase C of turkey erythrocyte membranes. (1988) (71)
- Activation of phosphoinositide 3-kinase gamma by Ras. (2002) (71)
- A new approach to measuring phosphoinositides in cells by mass spectrometry. (2014) (70)
- Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation. (1988) (66)
- PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils. (2010) (65)
- Lysophosphatidylinositol-Acyltransferase-1 (LPIAT1) Is Required to Maintain Physiological Levels of PtdIns and PtdInsP2 in the Mouse (2013) (65)
- Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity (2015) (64)
- Class IA Phosphoinositide 3-Kinase β and δ Regulate Neutrophil Oxidase Activation in Response to Aspergillus fumigatus Hyphae (2011) (63)
- Analysis of inositol metabolites produced by Saccharomyces cerevisiae in response to glucose stimulation. (1993) (63)
- Multiple metabolic pools of phosphoinositides and phosphatidate in human erythrocytes incubated in a medium that permits rapid transmembrane exchange of phosphate. (1987) (61)
- L-myo-inositol 1,4,5,6-tetrakisphosphate is present in both mammalian and avian cells. (1988) (61)
- Turkey erythrocyte membranes as a model for regulation of phospholipase C by guanine nucleotides. (1987) (57)
- Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8+ T Cells (2016) (55)
- ARAP3 is essential for formation of lamellipodia after growth factor stimulation (2006) (54)
- Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis (2013) (53)
- The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase. (2004) (53)
- The GTPase-activating protein ARAP3 regulates chemotaxis and adhesion-dependent processes in neutrophils. (2011) (52)
- P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils (2014) (52)
- Priming of human neutrophil superoxide generation by tumour necrosis factor‐α is signalled by enhanced phosphatidylinositol 3,4,5‐trisphosphate but not inositol 1,4,5‐trisphosphate accumulation (1998) (51)
- Activation of phosphatidylinositol 4,5-bisphosphate supply by agonists and non-hydrolysable GTP analogues. (1993) (51)
- Product-precursor relationships amongst inositol polyphosphates. Incorporation of [32P]Pi into myo-inositol 1,3,4,6-tetrakisphosphate, myo-inositol 1,3,4,5-tetrakisphosphate, myo-inositol 3,4,5,6-tetrakisphosphate and myo-inositol 1,3,4,5,6-pentakisphosphate in intact avian erythrocytes. (1990) (51)
- Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells (2016) (50)
- Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases. (1997) (50)
- Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits. (2005) (50)
- Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase. (2010) (48)
- PI3K Class IB Pathway (2007) (48)
- PI3K Class IB Pathway in Neutrophils (2007) (47)
- DAPP1 undergoes a PI 3-kinase-dependent cycle of plasma-membrane recruitment and endocytosis upon cell stimulation (2000) (47)
- Phosphatidylinositol 4,5-bisphosphate hydrolysis in turkey erythrocytes is regulated by P2y purinoceptors. (1989) (47)
- Functional Redundancy of Class I Phosphoinositide 3-Kinase (PI3K) Isoforms in Signaling Growth Factor-Mediated Human Neutrophil Survival (2012) (46)
- The role of PI3Ks in the regulation of the neutrophil NADPH oxidase. (2007) (46)
- GPCR activation of Ras and PI3Kγ in neutrophils depends on PLCβ2/β3 and the RasGEF RasGRP4 (2012) (45)
- Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes. (2010) (45)
- cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C Activity (2017) (45)
- Dictyostelium uses ether‐linked inositol phospholipids for intracellular signalling (2014) (45)
- L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase. (1988) (44)
- Phosphoinositol diphosphates: non-enzymic formation in vitro and occurrence in vivo in the cellular slime mold Dictyostelium (1992) (44)
- Signalling via phosphoinositide 3OH kinases. (1997) (39)
- Quantitative measurement of phosphatidylinositol 3,4,5-trisphosphate. (2007) (38)
- The regulatory subunits of PI3Kγ control distinct neutrophil responses (2015) (37)
- LL5β Is a Phosphatidylinositol (3,4,5)-Trisphosphate Sensor That Can Bind the Cytoskeletal Adaptor, γ-Filamin* 210 (2003) (37)
- General synthesis of 3-phosphorylated myo-inositol phospholipids and derivatives (1999) (36)
- Inositol polyphosphate metabolism and inositol lipids in a green alga, Chlamydomonas eugametos. (1992) (35)
- Effects of transformation with the v-src oncogene on inositol phosphate metabolism in rat-1 fibroblasts. D-myo-inositol 1,4,5,6-tetrakisphosphate is increased in v-src-transformed rat-1 fibroblasts and can be synthesized from D-myo-inositol 1,3,4-trisphosphate in cytosolic extracts. (1991) (34)
- RhoG Regulates the Neutrophil NADPH Oxidase1 (2006) (32)
- How is the acyl chain composition of phosphoinositides created and does it matter? (2019) (32)
- Use of the GRP1 PH domain as a tool to measure the relative levels of PtdIns(3,4,5)P3 through a protein-lipid overlay approach Published, JLR Papers in Press, November 27, 2006. (2007) (31)
- Synergistic activation of JNK/SAPK by interleukin-1 and platelet-derived growth factor is independent of Rac and Cdc42. (1999) (31)
- Src Family Kinases Mediate Receptor-stimulated, Phosphoinositide 3-Kinase-dependent, Tyrosine Phosphorylation of Dual Adaptor for Phosphotyrosine and 3-Phosphoinositides-1 in Endothelial and B Cell Lines* (2001) (30)
- In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function. (2017) (30)
- Mechanism of the regulation of type IB phosphoinositide 3OH-kinase byG-protein betagamma subunits. (2002) (30)
- An analysis of myo-[3H]inositol trisphosphates found in myo-[3H]inositol prelabelled avian erythrocytes. (1989) (29)
- LL5beta is a phosphatidylinositol (3,4,5)-trisphosphate sensor that can bind the cytoskeletal adaptor, gamma-filamin. (2003) (28)
- Receptor association and tyrosine phosphorylation of S6 kinases (2006) (27)
- Profiling of phosphoinositide molecular species in human and mouse platelets identifies new species increasing following stimulation. (2018) (26)
- Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors (2018) (26)
- Class (I) Phosphoinositide 3-Kinases in the Tumor Microenvironment (2017) (24)
- A heterotrimeric GTPase-regulated isoform of PI3K and the regulation of its potential effectors. (1996) (23)
- The Phosphoinositide 3-Kinase Isoform PI3Kβ Regulates Osteoclast-Mediated Bone Resorption in Humans and Mice (2014) (23)
- BMX acts downstream of PI3K to promote colorectal cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737. (2014) (23)
- Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase g (2000) (22)
- The metabolism and functions of inositol pentakisphosphate and inositol hexakisphosphate. (1989) (22)
- Perturbations of PIP3 signalling trigger a global remodelling of mRNA landscape and reveal a transcriptional feedback loop (2015) (22)
- 3D time series analysis of cell shape using Laplacian approaches (2013) (21)
- Phosphoinositide 3-OH Kinase Regulates Integrin-Dependent Processes in Neutrophils by Signaling through Its Effector ARAP3 (2013) (21)
- Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells (2018) (20)
- The hexosamine biosynthesis pathway and O‐GlcNAcylation maintain insulin‐stimulated PI3K‐PKB phosphorylation and tumour cell growth after short‐term glucose deprivation (2014) (20)
- Activation of the neutrophil NADPH oxidase by Aspergillus fumigatus (2012) (20)
- Synthesis and biological evaluation of aPtdIns(3,4,5)P3 affinity matrix (2001) (19)
- In B cells, phosphatidylinositol 5-phosphate 4-kinase–α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling (2016) (19)
- Investigating the effect of arachidonate supplementation on the phosphoinositide content of MCF10a breast epithelial cells (2016) (18)
- A myo-inositol D-3 hydroxykinase activity in Dictyostelium. (1990) (18)
- Multiple isomers of inositol pentakisphosphate in Epstein-Barr-virus- transformed (T5-1) B-lymphocytes. Identification of inositol 1,3,4,5,6-pentakisphosphate, D-inositol 1,2,4,5,6-pentakisphosphate and L-inositol 1,2,4,5,6-pentakisphosphate. (1991) (17)
- Determination of the steady-state turnover rates of the metabolically active pools of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in human erythrocytes. (1989) (16)
- The Inositol-3-Phosphate Synthase Biosynthetic Enzyme Has Distinct Catalytic and Metabolic Roles (2016) (16)
- Signaling via Class IA Phosphoinositide 3-Kinases (PI3K) in Human, Breast-Derived Cell Lines (2013) (14)
- Insulin and ATP stimulate actin polymerization in U937 cells by a wortmannin‐sensitive mechanism (1996) (14)
- Structural determinants of LL5beta subcellular localisation and association with filamin C. (2007) (14)
- An inositol 1,4,5-trisphosphate-6-kinase activity in pea roots (1992) (13)
- Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils (2020) (13)
- CD 18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI 3 Ks (2008) (13)
- Frontline Science: TNF‐α and GM‐CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K‐γ, and neutrophil proinflammatory responses (2019) (12)
- Agonist-stimulated inositol phosphate metabolism in avian erythrocytes. (1990) (12)
- Signalling via class IA PI3Ks. (2011) (11)
- Advances in Biological Regulation (2016) (11)
- Preparation and Separation of Inositol Tetrakisphosphates and Inositol Pentakisphosphates and the Establishment of Enantiomeric Configurations by the Use of L‐Iditol Dehydrogenase (1991) (10)
- Mechanism of the regulation of type IB phosphoinositide 3 OH-kinase by G-protein βγ subunits (10)
- Purification of ARAP3 and characterization of GAP activities. (2006) (10)
- Localizing the lipid products of PI3Kγ in neutrophils (2016) (9)
- RhoG Regulates the Neutrophil NADPH Oxidase (2006) (9)
- Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase (2022) (8)
- Corrigendum: Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ (2003) (7)
- Synthesis of dipalmitoyl phosphatidylinositol 3,4-bis(phosphate)and 3,4,5-tris(phosphate) and their enantiomers (1997) (7)
- GPCR activation of Ras and PI 3 K c in neutrophils depends on PLC b 2 / b 3 and the RasGEF RasGRP (2013) (6)
- Receptor and G-protein-dependent regulation of turkey erythrocyte phosphoinositidase C. (1988) (6)
- Inositol lipids and phosphates in erythrocytes and HL60 cells. (1988) (6)
- PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells (2021) (6)
- Fast random walker for neutrophil cell segmentation in 3D (2012) (5)
- More Paths to PI3Kγ (2013) (5)
- CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of E.coli or S.aureus is regulated by Class III but not Class I or II PI3Ks (2008) (4)
- Acyl chain selection couples the consumption and synthesis of phosphoinositides (2022) (4)
- 168 Structural analysis of a novel isoform of phosphoinositide 30H-kinase (1997) (4)
- The inositol 5-phosphatase INPP5B regulates B cell receptor clustering and signaling (2022) (3)
- The Phosphoinositide 3-Kinase Isoform PI 3 K Regulates Osteoclast-Mediated Bone Resorption in Humans and Mice (2014) (3)
- Modulation of Monomeric G Proteins by Phosphoinositides (2010) (3)
- Local Shape Representation in 3D: from Weighted Spherical Harmonics to Spherical Wavelet (2012) (3)
- Erratum: Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ (Nature (2000) 406 (897-902)) (2003) (3)
- More Paths to PI3Kc (2013) (1)
- PI3K regulates integrin-dependent processes in neutrophils by signalling through its effector ARAP3 (2013) (1)
- Metabolic pooling of inositol lipids in mature erythrocytes and in hormone-stimulated mammalian cells. (1987) (1)
- General Synthesis of 3‐Phosphorylated myo‐Inositol Phospholipids and Derivatives. (1999) (1)
- Resource Phosphoproteomic Analys es of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and-Independent Networks in CD 8 + T Cells Graphical Abstract Highlights (2016) (1)
- Structural analysis of a novel isoform of phosphoinositide 3OH-kinase. (1997) (1)
- CHAPTER 155 – Modulation of Monomeric G Proteins by Phosphoinositides (2003) (1)
- 3D time series analysis of cell shape using Laplacian approaches (2013) (1)
- Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells (2018) (1)
- Phosphoinositide 3OH Kinase Regulates Integrin-Dependent Processes in Neutrophils by Signaling through Its Effector ARAP 3 (2013) (1)
- STRUCTURAL INSIGHTS INTO PHOSHOINOSITIDE 3-KINASE ENZYMATIC MECHANISM AND SIGNALLING (1999) (1)
- Searching for novel targets of PtdIns(3,4,5)P3 and PtdIns(3,4)P2 (1999) (0)
- Signalling from cell surface receptors: molecular mechanisms and physiological significance of the phosphoinositide 3-kinase signalling system (2009) (0)
- Synthesis of Dipalmitoyl Phosphatidylinositol 3,4‐Bis(phosphate) and 3,4,5‐Tris(phosphate) and Their Enantiomers. (1998) (0)
- Heterogeneity Amongst Myo-Inositol Derivatives: Metabolism of Second Messengers and Synthesis of Co-Signals (1990) (0)
- Peter Lockyer BSc, PhD (1972–2006) (2007) (0)
- The roles of PI3Ks in cellular regulation (1997) (0)
- by Signaling through Its Effector ARAP3 Integrin-Dependent Processes in Neutrophils Phosphoinositide 3-OH Kinase Regulates (2012) (0)
- The LCLAT1/LYCAT acyltransferase supports EGF-mediated phosphatidylinositol-3,4,5-trisphosphate and Akt signaling (2023) (0)
- Table of Contents (1993) (0)
- PI3Ks in inflammation (2009) (0)
- Structure of Lipid Kinase p110b/p85b Elucidates anUnusualSH2-Domain-MediatedInhibitoryMechanism (0)
- Complexes PI 3 K { beta } Plays a Critical Role in Neutrophil Activation by Immune ` (2011) (0)
- Phosphoinositide 3-kinasey signalling: a structural perspective (2001) (0)
- ARFs get the BioID treatment: what have we been missing? (2022) (0)
- Hyphae Aspergillus fumigatus Response to Regulate Neutrophil Oxidase Activation in d and b Class IA Phosphoinositide 3-Kinase (2011) (0)
- Michael Wakelam (15 July 1955–31 March 2020) (2020) (0)
- OxidaseRhoG Regulates the Neutrophil NADPH (0)
- Vilasack Thammavongsa Promote Immune Cell Death Degrades Neutrophil Extracellular Traps to Staphylococcus aureus (2013) (0)
- S148 Regulation of neutrophil apoptosis by phosphoinositide 3-kinases (2010) (0)
- Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models (2023) (0)
- Signalling via PI3-kinases (2001) (0)
- Signalling via PI3Ks (2000) (0)
- Ras G12V - PI 3-kinase gamma complex (2001) (0)
- or II PI3Ks phagocytosis of E.coli or S.aureus is regulated by Class III but not Class I CD18-dependent activation of the neutrophil NADPH oxidase during (2013) (0)
- The inositol-3-phosphate synthase biosynthetic enzyme has distinct catalytic and 1 metabolic roles 2 3 4 (2016) (0)
- Identification of phosphoinositide-binding proteins by using phosphoinositide-coupled affinity matrices (2001) (0)
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