Leonid Kruglyak | Academic Influence

Leonid Kruglyak's AcademicInfluence.com Rankings

Leonid Kruglyak

Biology

#3206

World Rank

#4934

Historical Rank

Genetics

#341

World Rank

#400

Historical Rank

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Biology

Leonid Kruglyak's Degrees

PhD Genetics Stanford University
Bachelors Biology University of California, San Diego

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Why Is Leonid Kruglyak Influential?

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According to Wikipedia, Leonid Kruglyak is a scientist focusing on evolutionary genetics. He is the Chair of the Department of Human Genetics, a Distinguished Professor in the Departments of Human Genetics and Biological Chemistry and was appointed in 2020 The Diller-von Furstenberg Endowed Chair in Human Genetics at the David Geffen School of Medicine at the University of California Los Angeles.

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Leonid Kruglyak's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Finding the missing heritability of complex diseases (2009) (7749)
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results (1995) (5416)
Parametric and nonparametric linkage analysis: a unified multipoint approach. (1996) (3023)
Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. (1998) (2194)
Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. (2004) (1637)
Prospects for whole-genome linkage disequilibrium mapping of common disease genes (1999) (1427)
Genetic Dissection of Transcriptional Regulation in Budding Yeast (2002) (1413)
Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. (1997) (1120)
Variation is the spice of life (2001) (997)
Complete multipoint sib-pair analysis of qualitative and quantitative traits. (1995) (980)
Patterns of linkage disequilibrium in the human genome (2002) (879)
An STS-Based Map of the Human Genome (1995) (818)
Guilt by association (2000) (808)
The role of regulatory variation in complex traits and disease (2015) (804)
Genetics of global gene expression (2006) (670)
Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors (2003) (667)
Mapping complex disease loci in whole-genome association studies (2004) (662)
The landscape of genetic complexity across 5,700 gene expression traits in yeast. (2005) (632)
A comprehensive genetic map of the mouse genome (1996) (615)
Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks (2008) (553)
Population History and Natural Selection Shape Patterns of Genetic Variation in 132 Genes (2004) (505)
The use of a genetic map of biallelic markers in linkage studies (1997) (499)
A comprehensive genetic map of the mouse genome (1996) (497)
Disruption of the nuclear hormone receptor RORα in staggerer mice (1996) (436)
Finding the sources of missing heritability in a yeast cross (2012) (427)
Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae (2009) (424)
Dissection of genetically complex traits with extremely large pools of yeast segregants (2010) (395)
Genetic Structure of the Purebred Domestic Dog (2004) (394)
Recombinational Landscape and Population Genomics of Caenorhabditis elegans (2009) (373)
Gene–Environment Interaction in Yeast Gene Expression (2008) (372)
A nonparametric approach for mapping quantitative trait loci. (1995) (350)
Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity (2011) (347)
Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families (1996) (342)
Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans (2003) (322)
Genetic interactions between polymorphisms that affect gene expression in yeast (2005) (321)
Sexual orientation (1993) (308)
Extensive and breed-specific linkage disequilibrium in Canis familiaris. (2004) (304)
Linkage between sexual orientation and chromosome Xq28 in males but not in females (1995) (289)
Natural Malaria Infection in Anopheles gambiae Is Regulated by a Single Genomic Control Region (2006) (270)
The road to genome-wide association studies (2008) (265)
Widespread Genetic Incompatibility in C. Elegans Maintained by Balancing Selection (2008) (262)
Genome-Wide Detection of Polymorphisms at Nucleotide Resolution with a Single DNA Microarray (2006) (252)
Quantitative Mapping of a Digenic Behavioral Trait Implicates Globin Variation in C. elegans Sensory Behaviors (2009) (241)
High-resolution genetic mapping of complex traits. (1995) (241)
Rapid multipoint linkage analysis of recessive traits in nuclear families, including homozygosity mapping. (1995) (235)
A Polymorphism in npr-1 Is a Behavioral Determinant of Pathogen Susceptibility in C. elegans (2009) (234)
Genetic basis of proteome variation in yeast (2007) (231)
Selection at Linked Sites Shapes Heritable Phenotypic Variation in C. elegans (2010) (223)
Faster Multipoint Linkage Analysis Using Fourier Transforms (1998) (222)
Population genomic analysis of outcrossing and recombination in yeast (2006) (217)
Multiple Locus Linkage Analysis of Genomewide Expression in Yeast (2005) (204)
Telomere Length as a Quantitative Trait: Genome-Wide Survey and Genetic Mapping of Telomere Length-Control Genes in Yeast (2006) (199)
Catecholamine receptor polymorphisms affect decision-making in C. elegans (2011) (193)
Measuring differential gene expression by short read sequencing: quantitative comparison to 2-channel gene expression microarrays (2009) (191)
Siblings of centenarians live longer (1998) (187)
Disruption of the nuclear hormone receptor RORalpha in staggerer mice. (1996) (186)
Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations. (2004) (180)
The vibrator Mutation Causes Neurodegeneration via Reduced Expression of PITPα: Positional Complementation Cloning and Extragenic Suppression (1997) (179)
Building human genome maps with radiation hybrids (1997) (177)
Additional support for schizophrenia linkage on chromosomes 6 and 8: a multicenter study. Schizophrenia Linkage Collaborative Group for Chromosomes 3, 6 and 8. (1996) (175)
Local Regulatory Variation in Saccharomyces cerevisiae (2005) (175)
Unleashing the canine genome. (2000) (168)
Polymorphisms in Multiple Genes Contribute to the Spontaneous Mitochondrial Genome Instability of Saccharomyces cerevisiae S288C Strains (2009) (153)
Natural Variation in a Chloride Channel Subunit Confers Avermectin Resistance in C. elegans (2012) (148)
Efficient multipoint linkage analysis through reduction of inheritance space. (2001) (145)
A Variant in the Neuropeptide Receptor npr-1 is a Major Determinant of Caenorhabditis elegans Growth and Physiology (2014) (145)
Genomewide search for type 2 diabetes mellitus susceptibility loci in Finnish families: the Botnia study. (2002) (139)
Simultaneous genotyping, gene-expression measurement, and detection of allele-specific expression with oligonucleotide arrays. (2005) (137)
A Novel Sperm-Delivered Toxin Causes Late-Stage Embryo Lethality and Transmission Ratio Distortion in C. elegans (2011) (136)
Genetic Loci Affecting Resistance to Human Malaria Parasites in a West African Mosquito Vector Population (2002) (136)
Exact multipoint quantitative-trait linkage analysis in pedigrees by variance components. (2000) (136)
A new susceptibility locus for autosomal dominant pancreatic cancer maps to chromosome 4q32-34. (2002) (134)
Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegans (2008) (130)
Genetics of single-cell protein abundance variation in large yeast populations (2013) (129)
Genome scan of schizophrenia. (1996) (129)
Genetic interactions contribute less than additive effects to quantitative trait variation in yeast (2015) (125)
Genetic basis of individual differences in the response to small-molecule drugs in yeast (2007) (123)
A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set. (2003) (120)
Genome-Wide Analysis of Nucleotide-Level Variation in Commonly Used Saccharomyces cerevisiae Strains (2007) (119)
Absence of Detectable Arsenate in DNA from Arsenate-Grown GFAJ-1 Cells (2012) (118)
Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion. (2001) (117)
Genetic polymorphisms and disease. (1998) (113)
Remarkably Divergent Regions Punctuate the Genome Assembly of the Caenorhabditis elegans Hawaiian Strain CB4856 (2015) (109)
Genetic Variation Shapes Protein Networks Mainly through Non-transcriptional Mechanisms (2011) (107)
Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast (2016) (106)
Breeding Designs for Recombinant Inbred Advanced Intercross Lines (2008) (105)
Rise of the Machines (2008) (105)
Genetic control of serum IgE levels and asthma: linkage and linkage disequilibrium studies in an isolated population. (1997) (101)
A Natural Polymorphism in rDNA Replication Origins Links Origin Activation with Calorie Restriction and Lifespan (2013) (99)
Genetics of trans-regulatory variation in gene expression (2017) (97)
The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length (2016) (92)
Genome scan of schizophrenia (1998) (90)
A Powerful New Quantitative Genetics Platform, Combining Caenorhabditis elegans High-Throughput Fitness Assays with a Large Collection of Recombinant Strains (2015) (88)
Finding the missing heritability of complex (2009) (87)
Genetic Architecture of Highly Complex Chemical Resistance Traits across Four Yeast Strains (2012) (87)
Allele Frequency Matching Between SNPs Reveals an Excess of Linkage Disequilibrium in Genic Regions of the Human Genome (2006) (85)
CRISPR-directed mitotic recombination enables genetic mapping without crosses (2016) (82)
Genetic Influences on Translation in Yeast (2014) (80)
Full-genome evolutionary histories of selfing, splitting, and selection in Caenorhabditis (2014) (79)
Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype. (2000) (75)
Genetic isolates: separate but equal? (1999) (71)
A maternal-effect selfish genetic element in Caenorhabditis elegans (2017) (68)
Identification and Dissection of a Complex DNA Repair Sensitivity Phenotype in Baker's Yeast (2008) (67)
Non-newtonian forces and the invisible mass problem (1987) (64)
More Than the Sum of Its Parts: A Complex Epistatic Network Underlies Natural Variation in Thermal Preference Behavior in Caenorhabditis elegans (2012) (64)
Genetic dissection of complex traits in yeast: insights from studies of gene expression and other phenotypes in the BYxRM cross. (2009) (62)
Sequence variation and linkage disequilibrium in the human T-cell receptor beta (TCRB) locus. (2001) (61)
A genetic signature of the evolution of loss of flight in the Galapagos cormorant (2017) (60)
A Wild C. Elegans Strain Has Enhanced Epithelial Immunity to a Natural Microsporidian Parasite (2015) (59)
Highly parallel genome variant engineering with CRISPR/Cas9 (2017) (59)
Screening Human Embryos for Polygenic Traits Has Limited Utility (2019) (57)
Genetic Influences on Brain Gene Expression in Rats Selected for Tameness and Aggression (2014) (56)
What is significant in whole-genome linkage disequilibrium studies? (1997) (56)
An analysis of strategies for discovery of single‐nucleotide polymorphisms (2000) (55)
A practical algorithm for finding maximal exact matches in large sequence datasets using sparse suffix arrays (2009) (54)
Genetic Basis of Metabolome Variation in Yeast (2014) (52)
Long-Range Regulatory Polymorphisms Affecting a GABA Receptor Constitute a Quantitative Trait Locus (QTL) for Social Behavior in Caenorhabditis elegans (2012) (51)
Genetic variation in adaptability and pleiotropy in budding yeast (2017) (50)
Protein quantification across hundreds of experimental conditions (2009) (50)
Sib‐pair collection strategies for complex diseases (1998) (49)
Rare variants contribute disproportionately to quantitative trait variation in yeast (2019) (47)
Linkage thresholds for two-stage genome scans. (1998) (47)
Optimized detection of sequence variation in heterozygous genomes using DNA microarrays with isothermal-melting probes (2010) (45)
Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans (2012) (44)
Power tools for human genetics (2005) (44)
Genetic Mapping of MAPK-Mediated Complex Traits Across S. cerevisiae (2015) (44)
Limits on fine mapping of complex traits. (1996) (42)
Genetic epidemiologic studies on age-specified traits (2000) (42)
Quantitative measurement of allele-specific protein expression in a diploid yeast hybrid by LC-MS (2012) (41)
Swab-Seq: A high-throughput platform for massively scaled up SARS-CoV-2 testing (2020) (40)
Revealing complex traits with small molecules and naturally recombinant yeast strains. (2006) (40)
The genetic basis of natural variation in a phoretic behavior (2017) (39)
A locus for Fanconi anemia on 16q determined by homozygosity mapping. (1996) (36)
The Genetic Basis of Mutation Rate Variation in Yeast (2018) (36)
Correction: Disruption of the nuclear hormone receptor RORα in staggerer mice (Nature Journal (1996) 379 (736-739)) (1996) (36)
Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples (2021) (34)
Natural Polymorphism in BUL2 Links Cellular Amino Acid Availability with Chronological Aging and Telomere Maintenance in Yeast (2011) (33)
Comparative Developmental Expression Profiling of Two C. elegans Isolates (2008) (32)
Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk (2018) (30)
Nonparametric linkage tests are model free. (1997) (27)
How to Solve the N Bit Encoder Problem with Just Two Hidden Units (1990) (27)
Correction: A comprehensive genetic map of the mouse genome (Nature (1996) 380 (149-152)) (1996) (27)
Disruption of the nuclear hormone receptor RORα in staggerer mice (1996) (26)
Linkage disequilibrium mapping places the gene causing familial Mediterranean fever close to D16S246. (1996) (24)
Molecular genetics: DNA analysis of a putative dog clone (2006) (23)
Accurate proteome-wide protein quantification from high-resolution 15N mass spectra (2011) (22)
Variants in SUP45 and TRM10 Underlie Natural Variation in Translation Termination Efficiency in Saccharomyces cerevisiae (2011) (20)
Genetic Basis of Ammonium Toxicity Resistance in a Sake Strain of Yeast: A Mendelian Case (2013) (16)
Genetic Basis of Hidden Phenotypic Variation Revealed by Increased Translational Readthrough in Yeast (2012) (16)
Using Expression and Genotype to Predict Drug Response in Yeast (2009) (16)
Ubiquitous Selfish Toxin-Antidote Elements in Caenorhabditis Species (2020) (15)
Toxin-Antidote Elements Across the Tree of Life. (2020) (15)
Ancient balancing selection maintains incompatible versions of the galactose pathway in yeast (2021) (14)
Thresholds and sample sizes (1996) (14)
Genetic Basis of Haloperidol Resistance in Saccharomyces cerevisiae Is Complex and Dose Dependent (2014) (12)
Precise gene localization by phenotypic assay of radiation hybrid cells. (2000) (12)
Rapid cost-effective viral genome sequencing by V-seq (2020) (12)
Patterns Of Linkage Disequilbrium In The Human Genome (2002) (12)
Whole-organism eQTL mapping at cellular resolution with single-cell sequencing (2020) (11)
Systematic identification of cis-regulatory variants that cause gene expression differences in a yeast cross (2020) (11)
No support for linkage to the bipolar regions on chromosomes 4p, 18p, or 18q in 43 schizophrenia pedigrees. (2000) (10)
It's the Sequence, Stupid! (2008) (9)
No bias in linkage analysis. (2004) (8)
Do multiple data sets provide support for a bipolar illness susceptibility locus on chromosome 18? (1997) (8)
A minimal role for synonymous variation in human disease (2022) (7)
No evidence that synonymous mutations in yeast genes are mostly deleterious (2022) (7)
Genetics of Intraspecies Variation in Avoidance Behavior Induced by a Thermal Stimulus in Caenorhabditis elegans (2015) (7)
Who needs genetic markers? (1998) (7)
Genetics of white color and iridophoroma in “Lemon Frost” leopard geckos (2020) (7)
Cause and express (2009) (7)
Sampling SNPs (2000) (7)
Comment on 'Discrepancies in dbSNP confirmations rates and allele frequency distributions from varying genotyping error rates and patterns'. (2005) (6)
Correction: Telomere Length as a Quantitative Trait: Genome-Wide Survey and Genetic Mapping of Telomere Length-Control Genes in Yeast (2006) (6)
An Embarrassment of Switches (2007) (5)
Island-specific evolution of a sex-primed autosome in a sexual planarian (2022) (5)
Accounting for genetic interactions is necessary for accurate prediction of extreme phenotypic values of quantitative traits in yeast (2016) (4)
Towards synthetic PETtrophy: Engineering Pseudomonas putida for concurrent polyethylene terephthalate (PET) monomer metabolism and PET hydrolase expression (2022) (4)
The genetic basis of natural variation in C. elegans telomere length (2016) (4)
Erratum: Telomere length as a quantitative trait: Genome-wide survey and genetic mapping of telomere length-control genes in yeast (PloS Genetics (2006) 2, 3 DOI: 10.1371/journal.pgen.0020035) (2006) (3)
A Joint Analysis of Asthma Affection Status and IgE Levels in Multiple Data Sets Collected for Asthma (2001) (3)
Statistical Mechanics for a Network of Spiking Neurons (1993) (3)
Lower SARS-CoV-2 viral shedding following COVID-19 vaccination among healthcare workers in Los Angeles, California (2021) (3)
Analysis of the genetic basis of height in large Jewish nuclear families (2018) (3)
Lower Severe Acute Respiratory Syndrome Coronavirus 2 Viral Shedding Following Coronavirus Disease 2019 Vaccination Among Healthcare Workers in Los Angeles, California (2021) (3)
The role of genetic interactions in yeast quantitative traits (2015) (3)
The application of the polarographic method to the study of the kinetics of polymerization and copolymerization with styrene of 4-vinyldiphenyl and its derivatives☆ (1964) (2)
A high-resolution human SNP linkage map (2002) (2)
Analog Computation at a Critical Point: A Novel Function for Neuronal Oscillations? (1990) (2)
Retrospective Detection of SARS-CoV-2 in Symptomatic Patients prior to Widespread Diagnostic Testing in Southern California (2021) (2)
Genome-wide base editor screen identifies regulators of protein abundance in yeast (2022) (2)
Sequence-based linkage analysis. (2004) (2)
Quantitative genetics and the missing heritability problem (2018) (1)
Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans (2012) (1)
Ancient balancing selection maintains incompatible versions of a conserved metabolic pathway in yeast (2019) (1)
Genomic epidemiology of the Los Angeles COVID-19 outbreak and the early history of the B.1.43 strain in the USA (2020) (1)
Frequency-Matching SNPs Reveals Extended Linkage Disequilibrium in Genic Regions (2005) (1)
How Low Can You Go? (2018) (1)
Island-specific evolution of a sex-primed autosome in the planarian Schmidtea mediterranea (2021) (1)
Planarian Ovary Dissection for Ultrastructural Analysis and Antibody Staining. (2021) (1)
Cas9-induced nonhomologous recombination in C. elegans (2023) (1)
Highly parallel genome variant engineering with CRISPR–Cas9 (2018) (1)
ASHG AWARDS AND ADDRESSES 2015 Curt Stern Award 1 (2016) (1)
Likelihood Ratio Tests for Linkage and Linkage Disequilibrium : Asymptotic Distribution and Power (2007) (0)
Sibpair Collection Strategies in NIDDM (1996) (0)
BIOINFORMATICS ORIGINAL A practical algorithm for ﬁnding maximal exact matches in large sequence datasets using sparse sufﬁx arrays (2009) (0)
Sequencing Multiple Strains of Saccharomyces cerevisiae (0)
GFAJ-1 Cells Absence of Detectable Arsenate in DNA from Arsenate-Grown (2012) (0)
Single-nucleotide polymorphisms in human genetics (1999) (0)
The genetic basis of natural variation in a phoretic behavior (2017) (0)
Evolution. An embarrassment of switches. (2007) (0)
AnSTS-Based MapoftheHumanGenome (1995) (0)
Author response: Whole-organism eQTL mapping at cellular resolution with single-cell sequencing (0)
Drop-Off to Initiate No-Go Decay Dom 34 : Hbs 1 Promotes Subunit Dissociation and Peptidyl-tRNA (2012) (0)
Homozygosity mapping of Fanconi anemia (1994) (0)
Genomic epidemiology of the Los Angeles COVID-19 outbreak and the early history of the B.1.43 strain in the USA (2022) (0)
Human Chromosome 21 Species-Specific Transcription in Mice Carrying (2008) (0)
Author response: Systematic identification of cis-regulatory variants that cause gene expression differences in a yeast cross (2020) (0)
Insufficient evidence for non-neutrality of synonymous mutations (2023) (0)
Heritable Cas9-induced nonhomologous recombination in C. elegans (2023) (0)
Analog Computation at a Critical Point (1990) (0)
Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast (2017) (0)
Massively parallel identification of causal variants underlying gene expression differences in a yeast cross (2020) (0)
detection of allele-specific expression with oligonucleotide arrays Simultaneous genotyping , gene-expression measurement , and Material Supplemental (0)
Genetics of intra-species variation in avoidance behavior induced by a thermal stimulus in C. elegans (2015) (0)
Genetic influences on translation in yeast (2014) (0)
Whole-organism mapping of the genetics of gene expression at cellular resolution (2020) (0)
Fast genetic mapping of complex traits in C. elegans using millions of individuals in bulk (2019) (0)
for genetic interactions improves modeling of individual quantitative trait in yeast. (2017) (0)
Complex Traits and Simple Systems: An Interview with Leonid Kruglyak (2016) (0)
Computational Methods for the Genetic Dissection of Complex Diseases (2002) (0)
A maternal-effect genetic incompatibility in Caenorhabditis elegans (2017) (0)
2015 Curt Stern Award. (2016) (0)
Genetic dissection of MAPK-mediated complex traits across S. cerevisiae (2014) (0)
Accurate prediction of children's target height from their mid-parental height (2022) (0)
Science Journals — AAAS (2017) (0)
Natural variation in C. elegans response to N. parisii infection. (2015) (0)
Age-dependent variation in resistance to N. parisii infection. (2015) (0)
Exploring the genetic architecture of protein secretion in Komagataella phaffii (Pichia pastoris) for biotechnology applications (2022) (0)
Efficient and Scalable Algorithm for Surveying Relative Abundance of Biologically Important Compounds in High Resolution LC-MS/MS Data (2010) (0)
Loss of flight in the Galapagos cormorant mirrors human skeletal ciliopathies (2016) (0)
Faculty Opinions recommendation of The genetic architecture of divergence between threespine stickleback species. (2002) (0)
Oumou Niaré , Population Parasites in a West African Mosquito Vector Genetic Loci Affecting Resistance to Human Malaria (2008) (0)
Wang , the Human Genome Genotyping of Single-Nucleotide Polymorphisms in Large-Scale Identification , Mapping (2007) (0)

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