Leroy Liu | Academic Influence

Leroy Liu's AcademicInfluence.com Rankings

Leroy Liu

Biology

#14782

World Rank

#18632

Historical Rank

Cell Biology

#824

World Rank

#843

Historical Rank

Genetics

#1701

World Rank

#1811

Historical Rank

Molecular Biology

#2517

World Rank

#2557

Historical Rank

biology Degrees

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Biology

Leroy Liu's Degrees

Bachelors Biology National Taiwan University
Masters Molecular Biology National Taiwan University
PhD Molecular Biology National Taiwan University

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Why Is Leroy Liu Influential?

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According to Wikipedia, Leroy Fong Liu is a Taiwanese molecular biologist. Education and career Liu earned a Bachelor of Science degree in chemistry from National Taiwan University in 1971, and pursued doctoral study in the subject at the University of California, Berkeley, graduating in 1977. He conducted postdoctoral research at Harvard College until 1978, and moved to the University of California, San Francisco to continue postdoctoral studies. Between 1980 and 1992, Liu taught at the Johns Hopkins School of Medicine. He subsequently joined the faculty of Robert Wood Johnson Medical School at Rutgers University. In 2014, Liu returned to Taiwan for a position at Taipei Medical University.

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Leroy Liu's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes (2008) (2360)
Identification of the molecular basis of doxorubicin-induced cardiotoxicity (2012) (1396)
Transcription generates positively and negatively supercoiled domains in the template (1988) (636)
Topoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane. (2007) (502)
Type II DNA topoisomerases: Enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break (1980) (469)
Targeting mammalian target of rapamycin (mTOR) for health and diseases. (2007) (409)
Mechanism of Action of Camptothecin (1996) (399)
Transcription-driven supercoiling of DNA: Direct biochemical evidence from in vitro studies (1989) (285)
Ubiquitin-dependent Destruction of Topoisomerase I Is Stimulated by the Antitumor Drug Camptothecin* (1997) (261)
Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies (2007) (255)
Autophagy Regulates Ageing in C. elegans (2007) (219)
The Role of Autophagy in Mitochondria Maintenance: Characterization of Mitochondrial Functions in Autophagy-Deficient S. cerevisiae Strains (2007) (215)
Chemotherapeutics and Radiation Stimulate MHC Class I Expression through Elevated Interferon-beta Signaling in Breast Cancer Cells (2012) (210)
T4 DNA topoisomerase: a new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication (1979) (207)
Topors Functions as an E3 Ubiquitin Ligase with Specific E2 Enzymes and Ubiquitinates p53* (2004) (195)
Etoposide Induces ATM-Dependent Mitochondrial Biogenesis through AMPK Activation (2008) (188)
26 S Proteasome-mediated Degradation of Topoisomerase II Cleavable Complexes* (2001) (187)
Mechanism of Action of Camptothecin (1996) (166)
Newly replicated DNA is associated with DNA topoisomerase II in cultured rat prostatic adenocarcinoma cells (1986) (164)
SUMO-1 Conjugation to Human DNA Topoisomerase II Isozymes* (2000) (154)
Elevated expression of ISG15 in tumor cells interferes with the ubiquitin/26S proteasome pathway. (2006) (153)
DNA-DNA gyrase complex: the wrapping of the DNA duplex outside the enzyme (1978) (152)
Role of Topoisomerase IIβ in the Expression of Developmentally RegulatedGenes (2006) (150)
Transcription-Dependent Degradation of Topoisomerase I-DNA Covalent Complexes (2003) (140)
DNA Damage-mediated Apoptosis Induced by Selenium Compounds* (2003) (139)
Hydrogen Peroxide Induces Topoisomerase I-mediated DNA Damage and Cell Death* (2004) (131)
A Protease Pathway for the Repair of Topoisomerase II-DNA Covalent Complexes* (2006) (131)
In vivo mapping of DNA topoisomerase II-specific cleavage sites on SV40 chromatin (1985) (125)
Nuclear Translocation of Cytochrome c during Apoptosis* (2004) (113)
5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity. (2003) (90)
Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug. (2003) (89)
The topoisomerase IIβ circular clamp arrests transcription and signals a 26S proteasome pathway (2003) (87)
A Ubiquitin-Proteasome Pathway for the Repair of Topoisomerase I-DNA Covalent Complexes* (2008) (87)
ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cells (2012) (82)
5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: variation of n-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance. (2005) (82)
Macrocyclic pyridyl polyoxazoles: selective RNA and DNA G-quadruplex ligands as antitumor agents. (2010) (79)
Substituted dibenzo[c,h]cinnolines: topoisomerase I-targeting anticancer agents. (2003) (73)
Acidic pH induces topoisomerase II-mediated DNA damage (2003) (70)
Assembly of a Polymeric Chain of SUMO1 on Human Topoisomerase I in Vitro* (2006) (69)
Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro (2014) (63)
ISG15 as a novel tumor biomarker for drug sensitivity (2008) (63)
Inactivation of Cdc13p TriggersMEC1-dependent Apoptotic Signals in Yeast* (2003) (62)
Nucleolytic Cleavage of the Mixed Lineage Leukemia Breakpoint Cluster Region during Apoptosis* (2001) (61)
Proteasome-dependent Processing of Topoisomerase I-DNA Adducts into DNA Double Strand Breaks at Arrested Replication Forks* (2009) (61)
G-quadruplexes induce apoptosis in tumor cells. (2006) (59)
Single-stranded DNA Induces Ataxia Telangiectasia Mutant (ATM)/p53-dependent DNA Damage and Apoptotic Signals* (2003) (57)
ATP-bound Topoisomerase II as a Target for Antitumor Drugs* (2001) (56)
11H-Isoquino[4,3-c]cinnolin-12-ones; novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity. (2004) (55)
Isodiospyrin as a novel human DNA topoisomerase I inhibitor. (2003) (53)
Mutations of human topoisomerase IIα affecting multidrug resistance and sensitivity (1999) (53)
Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435. (2002) (51)
Genistein induces topoisomerase IIbeta- and proteasome-mediated DNA sequence rearrangements: Implications in infant leukemia. (2010) (49)
Topoisomerases as Novel Targets for Cancer Chemotherapy (1988) (49)
Role of apoptotic nuclease caspase-activated DNase in etoposide-induced treatment-related acute myelogenous leukemia. (2006) (48)
Dietary Isothiocyanate-induced Apoptosis via Thiol Modification of DNA Topoisomerase IIα* (2011) (47)
A Novel Role for ATM in Regulating Proteasome-Mediated Protein Degradation through Suppression of the ISG15 Conjugation Pathway (2011) (47)
Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[i]phenanthridine-12-carboxylic acid: potent cytotoxic and topoisomerase I-targeting agents. (2005) (46)
Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: effect on topoisomerase-I targeting activity and cytotoxicity. (2003) (45)
Chapter II – DNA Topoisomerases: Enzymes That Catalyze the Concerted Breaking and Rejoining of DNA Backbone Bonds (1979) (45)
Phosphorylation of Ubc9 by Cdk1 Enhances SUMOylation Activity (2012) (43)
A G-quadruplex Stabilizer Induces M-phase Cell Cycle Arrest* (2009) (42)
Potent antitumor 9-anilinoacridines and acridines bearing an alkylating N-mustard residue on the acridine chromophore: synthesis and biological activity. (2006) (40)
2,3-Dimethoxybenzo[i]phenanthridines: topoisomerase I-targeting anticancer agents. (2003) (39)
Crosstalk between integrin αvβ3 and ERα contributes to thyroid hormone-induced proliferation of ovarian cancer cells (2016) (38)
Structure activity of topoisomerase i poisons related to hoechst 33342 (1994) (38)
Therapeutic applications of resveratrol and its derivatives on periodontitis (2017) (37)
Chapter 24. DNA Topoisomerases as Therapeutic Targets in Cancer Chemotherapy (1986) (35)
Mechanisms of ceramide‐induced COX‐2‐dependent apoptosis in human ovarian cancer OVCAR‐3 cells partially overlapped with resveratrol (2013) (35)
A Vaccine Targeted at CETP Alleviates High Fat and High Cholesterol Diet-Induced Atherosclerosis and Non-Alcoholic Steatohepatitis in Rabbit (2014) (35)
Mechanisms of dihydrotestosterone action on resveratrol-induced anti-proliferation in breast cancer cells with different ERα status (2015) (34)
Substituted benzo[i]phenanthridines as mammalian topoisomerase-targeting agents. (2003) (34)
Role of DNA topoisomerase IIβ in neurite outgrowth (2007) (32)
Potent antitumor 9-anilinoacridines bearing an alkylating N-mustard residue on the anilino ring: synthesis and biological activity. (2005) (31)
Tetrac downregulates β-catenin and HMGA2 to promote the effect of resveratrol in colon cancer. (2017) (31)
Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity. (2004) (30)
8,9-methylenedioxybenzo[i]phenanthridines: topoisomerase I-targeting activity and cytotoxicity. (2003) (30)
DNA Topoisomerases : Topoisomerase-targeting drugs (1994) (30)
Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity. (2010) (29)
2,3,5,4′-Tetrahydroxystilbene-2-O-β-glucoside Isolated from Polygoni Multiflori Ameliorates the Development of Periodontitis (2016) (28)
[7] HeLa toposiomerase I (1983) (27)
Ring-closing metathesis for the synthesis of a highly G-quadruplex selective macrocyclic hexaoxazole having enhanced cytotoxic potency. (2008) (27)
The combination of tetraiodothyroacetic acid and cetuximab inhibits cell proliferation in colorectal cancers with different K-ras status (2016) (27)
DNA Topoisomerases : biochemistry and molecular biology (1994) (26)
Ubiquitin, SUMO‐1, and UCRP in Camptothecin Sensitivity and Resistance (2000) (25)
11 DNA Replication: Topological Aspects and the Roles of DNA Topoisomerases (1990) (24)
Activation of a Novel Ubiquitin-Independent Proteasome Pathway when RNA Polymerase II Encounters a Protein Roadblock (2013) (24)
Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells (2014) (23)
Interferon-β Signaling Contributes to Ras Transformation (2011) (22)
Roleof Topoisomerase II in MediatingEpipodophyllotoxin-induced DMA Cleavage1 (1984) (22)
6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity. (2006) (21)
Protection of DNA Ends by Telomeric 3′ G-Tail Sequences* (2007) (21)
Topoisomerase I-targeting drugs. New developments in cancer pharmacology (1998) (21)
Thyroid hormone-induced expression of inflammatory cytokines interfere with resveratrol-induced anti-proliferation of oral cancer cells. (2019) (21)
Modulation of Gyrase-Mediated DNA Cleavage and Cell Killing by ATP (1998) (20)
14 Anticancer Drugs That Convert DNA Topoisomerases into DNA Damaging Agents (1990) (20)
Nano-Diamino-Tetrac (NDAT) Enhances Resveratrol-Induced Antiproliferation by Action on the RRM2 Pathway in Colorectal Cancers (2018) (20)
Intracellular Target of the Anticancer Drug Camptothecin Identification of Mammalian DNA Topoisomerase I as an Updated (2006) (20)
Role of DNA topoisomerase IIbeta in neurite outgrowth. (2007) (18)
Novel topoisomerase I-targeting antitumor agents synthesized from the N,N,N-trimethylammonium derivative of ARC-111, 5H-2,3-dimethoxy-8,9-methylenedioxy-5-[(2-N,N,N-trimethylammonium)ethyl]dibenzo[c,h][1,6]naphthyridin-6-one iodide. (2008) (18)
Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity. (2004) (17)
Inhibitory Effect of Anoectochilus formosanus Extract on Hyperglycemia-Related PD-L1 Expression and Cancer Proliferation (2018) (17)
A Structured–Activity Relationship Study of Batracylin Analogues (1993) (16)
Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents. (2008) (16)
12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents. (2009) (15)
Induction of sister chromatid exchanges by inhibitors of topoisomerases (1986) (14)
Macrocyclic biphenyl tetraoxazoles: synthesis, evaluation as G-quadruplex stabilizers and cytotoxic activity. (2013) (13)
On the mechanism of sodium cyanoborohydride reduction of tosylhydrazones (1988) (13)
11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents. (2008) (13)
Substituted 2,5′-Bi-1H-benzimidazoles: Topoisomerase I Inhibition and Cytotoxicity. (1996) (13)
5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones and related compounds as TOP1-targeting agents: influence of structure on the ternary cleavable complex formation. (2003) (12)
Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31). (2008) (12)
Novel leptin OB3 peptide-induced signaling and progression in thyroid cancers: Comparison with leptin (2016) (11)
TOR Regulates Cell Death Induced by Telomere Dysfunction in Budding Yeast (2008) (11)
Facile formation of hydrophilic derivatives of 5H-8,9-dimethoxy-5-[2-(N,N-dimethylamino)ethyl]-2,3-methylenedioxydibenzo[c,h] [1,6]naphthyridin-6-one (ARC-111) and its 12-aza analog via quaternary ammonium intermediates. (2008) (10)
Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones. (2009) (9)
A novel synthetic bipartite carrier protein for developing glycotope-based vaccines. (2012) (9)
Topoisomerase IIβ Deficiency Enhances Camptothecin-induced Apoptosis* (2013) (8)
18 – Roles of DNA Topoisomerases in Drug Cytotoxicity and Drug Resistance (1988) (8)
Doxorubicin Cardiotoxicity Revisited: Ros Versus Top2 (2012) (7)
Macrocyclic Pyridyl Polyoxazoles: Structure-Activity Studies of the Aminoalkyl Side-Chain on G-Quadruplex Stabilization and Cytotoxic Activity (2013) (7)
Polygonum multiflorum Decreases Airway Allergic Symptoms in a Murine Model of Asthma. (2016) (6)
DNA STRAND PASSING AND THE FUNCTION OF TYPE II DNA TOPOISOMERASES (1980) (6)
Cytotoxicity of 5H-Dibenzo[c,h][1,6]naphthyridin-6-ones and 6H-Indeno[1,2-c]isoquinolin-5,11-diones in Tumor Cells Sensitive and Resistant to Camptothecin Analogs (2004) (6)
Aza-analogs of dibenzo[c,h]cinnoline: Triazachrysenes as potent topoisomerase I-targeting anticancer agents (2003) (6)
in Tumor Cells CamptothecinTopoisomerase I As a Resistance Mechanism to Ubiquitin / 26 S Proteasome-mediated Degradation of Updated Version (2001) (5)
Rapid Chromatin Reorganization Induced by Topoisomerase I‐Mediated DNA Damage (2000) (5)
The cytokine-cosmc signaling axis upregulates the tumor-associated carbohydrate antigen Tn (2016) (4)
Ubiquitin / 26 S Proteasome-mediated Degradation of Topoisomerase I As a Resistance Mechanism to Camptothecin in Tumor Cells 1 (2001) (2)
Characterization and Mechanism of Resistance Cell Line of Human Non-Small Cell Lung Cancer : Establishment of a Camptothecin Analogue ( CPT-11 )-resistant (2006) (1)
Design of Antineoplastic Agents Based on the “2-Phenylnaphthalene-Type” Structural Pattern. Part 4. Synthesis and Biological Activity of 2-Chloro-3-(substituted phenoxy)-1,4-naphthoquinones and Related 5,8-Dihydroxy-1,4-naphthoquinones. (1999) (1)
Diaza- and Triazachrysenes: Potent Topoisomerase-Targeting Agents with Exceptional Antitumor Activity Against the Human Tumor Xenograft, MDA-MB-435 (2003) (1)
Camptothecin Overcomes MDR 1-mediated Resistance in Human KB Carcinoma Cells 1 (2006) (1)
GROWTH REGULATION OF MAMMALIAN DNA TOPOISOMERASE II RESULTS Effect of Serum on Intracellular Levels of DNA (1988) (1)
Abstract C76: Oxazole‐containing macrocyles as selective G‐quadruplex stabilizers (2009) (1)
Erratum: "Polygonum multiflorum Decreases Airway Allergic Symptoms in a Murine Model of Asthma". (2017) (1)
Degradation of topoisomerase cleavable complexes (2003) (1)
Ceramide Induces COX-2-dependent Induction of Apoptosis in Human Ovarian Cancer OVCAR-3 Cells by Mechanisms that Partially Overlap with Actions of Resveratrol † (2013) (1)
Abstract A36: Topoisomerase II-dependent apoptosis induced by dietary isothiocyanates (2010) (1)
Phosphorylation of Ubc9 by Cdk1/cyclin B: A Possible Link of Sumoylation to Cell Cycle Progression (2011) (0)
RESULTS Production of Antibodies to a Polypeptide from Chicken Chromosome Scaffolds (2002) (0)
ATP-dependent partitioning of the DNA template into supercoiled domains by Escherichia coli UvrAB (2004) (0)
Correction: Novel leptin OB3 peptide-induced signaling and progression in thyroid cancers: Comparison with leptin (2017) (0)
Dissolved topoisomerase poisons (2002) (0)
Perturbation of Cell Cycle Progression by A G‐Quadruplex‐Specific Stabilizer (2009) (0)
Methylenedioxybenzo [i] phenanthridinderivater used for treating cancer (2010) (0)
p34cdc2/Cyclin B Camptothecin-induced G2 Arrest: Altered Regulation of The Involvement of Active DNA Synthesis in (2013) (0)
Role of Topoisomerase II (cid:2) in the Expression of Developmentally Regulated Genes (cid:1) † (2006) (0)
DNA nucleotide sequencing analysis of topo I cleavage sites on SV 40 DNA (2005) (0)
The camptothecins: Unfolding their anticancer potential: Introduction (2000) (0)
Abstract 3438: Oncogenes-induced interferon-beta: modulation of tranformation phenotypes through interferon-ISG15 autocrine signaling (2011) (0)
Protoberberine Alkaloid Coralyne Identification of Topoisomerase I as the Cytotoxic Target of the Updated (2006) (0)
Mechanism of Action of Topoisomerase 1 Poisons (2005) (0)
The 'rca' A gene from 'Aspergillus nidulans' is related to the human nibrin gene and is required for camptothecin resistance (1999) (0)
Hoechst 33342 induced limited but highly specific single-strand breaks on YEpG DNA in the presence of calf thymus DNA Topo (2005) (0)
Topoisomerase II Is a Mitotic Chromosome Structural Scaffolds Component of (1985) (0)
Abstract #LB-210: Mitoxantrone-amino acid conjugates: novel topoisomerase II-targeting agents with a different drug resistant profile (2009) (0)
Nucleic Acids Research (2010) (0)
Human KB Carcinoma Cells Camptothecin Overcomes MDR 1-mediated Resistance in Updated (2006) (0)

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