Leslie J. Berg | Academic Influence

Leslie J. Berg's AcademicInfluence.com Rankings

Leslie J. Berg

Biology

#9994

World Rank

#13270

Historical Rank

Immunology

#776

World Rank

#799

Historical Rank

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Biology

Leslie J. Berg's Degrees

PhD Immunology University of Texas Southwestern Medical Center
Bachelors Biology University of Texas at Austin

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Why Is Leslie J. Berg Influential?

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According to Wikipedia, Leslie Joan Berg is an American immunologist. As a professor at University of Massachusetts Medical School, she was elected the 95th president of the American Association of Immunologists for a one-year term from 2011 to 2012. Berg’s research focuses on understanding the signal transduction pathways—the succession of reactions inside the cell as it changes one kind of stimulus, or signal, into another—important for T-cell development and activation, and the generation of protective immunity to infections.

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Leslie J. Berg's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Janeway's immunobiology (2007) (2296)
Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3 (1995) (572)
T-cell signaling regulated by the Tec family kinase, Itk. (2010) (494)
A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. (1996) (471)
Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42. (1995) (418)
Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand (1989) (409)
T Cell Receptor–initiated Calcium Release Is Uncoupled from Capacitative Calcium Entry in Itk-deficient T Cells (1998) (361)
Tec family kinases in T lymphocyte development and function. (2005) (349)
Biochemical Interactions Integrating Itk with the T Cell Receptor-initiated Signaling Cascade* (2000) (304)
Regulatory intramolecular association in a tyrosine kinase of the Tec family (1997) (275)
The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells. (2006) (214)
Identification of Itk/Tsk Src Homology 3 Domain Ligands* (1996) (195)
Lck Phosphorylates the Activation Loop Tyrosine of the Itk Kinase Domain and Activates Itk Kinase Activity* (1997) (191)
p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation. (1995) (190)
Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes (2012) (184)
Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. (2011) (184)
Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet. (2004) (180)
Signalling through TEC kinases regulates conventional versus innate CD8+ T-cell development (2007) (164)
Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection (1989) (153)
A network of high-mobility group box transcription factors programs innate interleukin-17 production. (2013) (148)
Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk. (1993) (138)
Interleukin 7 Receptor Control of T Cell Receptor γ Gene Rearrangement: Role of Receptor-associated Chains and Locus Accessibility (1998) (137)
Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation. (2008) (135)
The effects of MHC gene dosage and allelic variation on T cell receptor selection (1990) (134)
TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection. (2015) (128)
The role of cytokine receptor signaling in lymphocyte development. (1999) (128)
Tec kinase Itk in γδT cells is pivotal for controlling IgE production in vivo (2009) (126)
The Tec Kinases Itk and Rlk Regulate NKT Cell Maturation, Cytokine Production, and Survival1 (2008) (124)
Suppression of systemic autoimmunity by the innate immune adaptor STING (2015) (124)
Graded Levels of IRF4 Regulate CD8+ T Cell Differentiation and Expansion, but Not Attrition, in Response to Acute Virus Infection (2014) (102)
Epigenetic modifications induced by Blimp-1 Regulate CD8⁺ T cell memory progression during acute virus infection. (2013) (101)
TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation (2012) (101)
New insights into the regulation and functions of Tec family tyrosine kinases in the immune system. (2002) (100)
Peripheral Expression of Jak3 Is Required to Maintain T Lymphocyte Function (1997) (98)
A peptide antigen antagonist prevents the differentiation of T cell receptor transgenic thymocytes. (1994) (97)
The role of Jak3 in lymphoid development, activation, and signaling. (1997) (91)
Defective Fas Ligand Expression and Activation-Induced Cell Death in the Absence of IL-2-Inducible T Cell Kinase1 (2002) (89)
The Tec kinases Itk and Rlk regulate conventional versus innate T‐cell development (2009) (88)
The role of Tec family kinases in T cell development and function (2003) (87)
Itk Phosphorylation Sites Are Required for Functional Activity in Primary T Cells* (2003) (86)
Tec Kinase Signaling in T Cells Is Regulated by Phosphatidylinositol 3-Kinase and the Tec Pleckstrin Homology Domain1 (2001) (83)
The Absence of Itk Inhibits Positive Selection Without Changing Lineage Commitment1 (2002) (80)
Homodimerization of Interleukin-4 Receptor α Chain Can Induce Intracellular Signaling* (1996) (77)
Induction of autoimmune disease in mice by germline alteration of the T cell receptor gene expression. (1994) (76)
Tec kinases in T cell and mast cell signaling. (2007) (71)
Molecular determinants of TCR expression and selection. (2001) (66)
T cells from Jak3-deficient mice have intact TCR signaling, but increased apoptosis. (1997) (64)
IFN-αβ and Self-MHC Divert CD8 T Cells into a Distinct Differentiation Pathway Characterized by Rapid Acquisition of Effector Functions (2010) (62)
Tec Kinases Itk and Rlk Are Required for CD8+ T Cell Responses to Virus Infection Independent of Their Role in CD4+ T Cell Help1 (2006) (62)
Expression of T-cell receptor alpha-chain genes in transgenic mice (1988) (60)
Dysregulated myelopoiesis in mice lacking Jak3. (1999) (59)
T cell development and activation in Jak3‐deficient mice (1998) (59)
Intrathymic programming of effector fates in three molecularly distinct {gamma}{delta} T cell subtypes (2012) (57)
T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells (2016) (54)
Developmental regulation of thymocyte susceptibility to deletion by "self"-peptide (1992) (49)
NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection (2017) (48)
Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help. (2006) (48)
CD28 and ITK signals regulate autoreactive T cell trafficking (2013) (45)
Itk and Th2 responses: action but no reaction. (2006) (41)
Jarid2 is induced by TCR signalling and controls iNKT cell maturation (2014) (38)
CHROMOPHORE‐ASSISTED LASER INACTIVATION OF SUBUNITS OF THE T‐CELL RECEPTOR IN LIVING CELLS IS SPATIALLY RESTRICTED (1995) (36)
Insights into the role of the immune system in prion diseases. (1994) (32)
Cutting Edge: An Alternative Pathway of CD4+ T Cell Differentiation Is Induced Following Activation in the Absence of γ-Chain-Dependent Cytokine Signals1 (2006) (31)
A Profound Deficiency in Thymic Progenitor Cells in Mice Lacking Jak31 (2000) (30)
The Tec Kinase ITK Regulates Thymic Expansion, Emigration, and Maturation of γδ NKT Cells (2013) (30)
Activation Loop Dynamics Determine the Different Catalytic Efficiencies of B Cell– and T Cell–Specific Tec Kinases (2013) (28)
Subtle Defects in Pre-TCR Signaling in the Absence of the Tec Kinase Itk1 (2007) (28)
Cutting Edge: Itk Is Not Essential for CD28 Signaling in Naive T Cells1 (2005) (28)
Itk is not essential for CD28 signaling in naive T cells. (2005) (27)
Phenotypic differences between alpha beta versus beta T-cell receptor transgenic mice undergoing negative selection. (1989) (26)
Characterization of a novel interaction between transcription factor TFII‐I and the inducible tyrosine kinase in T cells (2009) (24)
A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression (2015) (24)
Cutting Edge: Two Distinct Mechanisms Lead to Impaired T Cell Homeostasis in Janus Kinase 3- and CTLA-4-Deficient Mice1 (2001) (23)
Development of Innate CD4+ and CD8+ T Cells in Itk-Deficient Mice Is Regulated by Distinct Pathways (2014) (23)
Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response. (2018) (23)
Cell Cycle Progression following Naive T Cell Activation Is Independent of Jak3/Common γ-Chain Cytokine Signals1 (2009) (23)
Quantitative Analysis of the Efficiency of Clonal Deletion in the Thymus (1994) (22)
Compartmentalized Eph receptor and ephrin expression in the thymus (2002) (22)
Innate PLZF+CD4+ αβ T Cells Develop and Expand in the Absence of Itk (2014) (19)
Structurally similar TCRs differ in their efficiency of positive selection. (1997) (19)
Type 1 interferon licenses naïve CD8 T cells to mediate anti-viral cytotoxicity. (2016) (19)
The Jak family tyrosine kinase Jak3 is required for IL-2 synthesis by naive/resting CD4+ T cells. (1999) (18)
High pathogen burden in childhood promotes the development of unconventional innate-like CD8+ T cells. (2017) (18)
Strength of T cell receptor signaling strikes again. (2009) (17)
The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine (2019) (16)
The Transcription Factor Runx2 Is Required for Long-Term Persistence of Antiviral CD8+ Memory T Cells (2018) (16)
Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory (2017) (16)
Peptide Antigen Concentration Modulates Digital NFAT1 Activation in Primary Mouse Naive CD8+ T Cells as Measured by Flow Cytometry of Isolated Cell Nuclei (2018) (15)
Faculty Opinions recommendation of Four tyrosine residues in phospholipase C-gamma 2, identified as Btk-dependent phosphorylation sites, are required for B cell antigen receptor-coupled calcium signaling. (2001) (15)
Disrupting the Intermolecular Self-Association of Itk Enhances T Cell Signaling (2010) (15)
Genomic structure and promoter region of the murine Janus-family tyrosine kinase, Jak3. (1997) (14)
Compartmentalized Eph receptor and ephrin expression in the thymus. (2002) (14)
IRF4 Regulates the Ratio of T-Bet to Eomesodermin in CD8+ T Cells Responding to Persistent LCMV Infection (2015) (14)
Faculty Opinions recommendation of Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling. (2001) (13)
Enhanced T cell maturation and altered lineage commitment in T cell receptor/CD4-transgenic mice. (1995) (13)
Alterations in CD4-binding regions of the MHC class II molecule I-Ek do not impede CD4+ T cell development. (1999) (13)
Activation of the Tec Kinase ITK Controls Graded IRF4 Expression in Response to Variations in TCR Signal Strength (2020) (12)
Hierarchy of signaling thresholds downstream of the T cell receptor and the Tec kinase ITK (2021) (12)
Alterations in CD4 dependence accompany T cell development and differentiation. (1996) (9)
CD8+ T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine (2020) (8)
A monoclonal antibody reactive with a 40-kDa molecule on fetal thymocytes and tumor cells blocks proliferation and stimulates aggregation and apoptosis. (1999) (7)
The “Bubble Boy” Paradox: An Answer That Led to a Question (2008) (7)
T-cell development in T cell receptor alphabeta transgenic mice. (1989) (7)
TCR recognition and selection in vivo. (1989) (6)
Analysis of the individual role of the TCRzeta chain in transgenic mice after conditional activation with chemical inducers of dimerization. (2001) (5)
Signaling Pathways That Regulate T Cell Development and Differentiation (2012) (5)
Regulation of Tissue-Dependent Differences in CD8+ T Cell Apoptosis during Viral Infection (2014) (5)
Signals that regulate lymphocyte development and differentiation. (2004) (3)
Optimized Detection of Acute MHV68 Infection With a Reporter System Identifies Large Peritoneal Macrophages as a Dominant Target of Primary Infection (2020) (3)
c-Abl, an additional tyrosine kinase required for T cell development and function (2008) (2)
-Chain Cytokine Signals g Activation Is Independent of Jak3/Common Cell Cycle Progression following Naive T Cell (2009) (2)
The Tec kinase ITK differentially optimizes NFAT, NF-κB, and MAPK signaling during early T cell activation to regulate graded gene induction (2020) (2)
TCR signaling: it’s all about the numbers (2019) (2)
Do the CD4 and CD8 lineages represent parallel pathways? (1994) (2)
The transcription factor ZBTB32 negatively regulates CD8+ T cell responses during acute and chronic viral infection (VIR4P.1010) (2014) (2)
The role of Runx2 in CD8+ T cell memory during acute LCMV Armstrong infection (2017) (1)
Itk acts as a negative regulator in mast cell activation (91.19) (2009) (1)
Gene-enhancer variants reveal diverse TCR-mediated differentiation (2017) (1)
Cutting Edge : Two Distinct Mechanisms Lead to Impaired T Cell Homeostasis in Janus Kinase 3and 3and 3and CTLA4Deficient CTLA4Deficient CTLA4Deficient 4Deficient 4Deficient Mice 1 (2000) (1)
Interplay between IL-10, IFN-γ, IL-17A and PD-1 Expressing EBNA1-Specific CD4+ and CD8+ T Cell Responses in the Etiologic Pathway to Endemic Burkitt Lymphoma (2021) (1)
Pleckstrin Homology Domain by Phosphatidylinositol 3-Kinase and the Tec Tec Kinase Signaling in T Cells Is Regulated (2013) (1)
Role for Blimp-1 in the generation and function of cytotoxic CD4 effector T cells identified by NKG2A/C/E expression (P6046) (2013) (1)
II-13 Suppression of systemic autoimmunity by the innate immune adaptor sting (2016) (1)
The signal transduction of motion and antigen recognition: factors affecting T cell function and differentiation. (1998) (1)
The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine (2019) (0)
Faculty Opinions recommendation of Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways. (2002) (0)
Without Changing Lineage Commitment The Absence of Itk Inhibits Positive Selection (2002) (0)
Different by Destruction: Unequal Inheritance of the Transcription Factor T-bet as a Mechanism to Diversify Daughter T Cell Fates (47.29) (2009) (0)
Critical role of ITK in mouse γ-herpes virus 68 infection as a model for human immunodeficiency (VIR1P.1140) (2015) (0)
Distinct Pathways Cells in Itk-Deficient Mice Is Regulated by T + and CD8 + Development of Innate CD4 (2014) (0)
of IL-2-Inducible T Cell Kinase Activation-Induced Cell Death in the Absence Defective Fas Ligand Expression and (2002) (0)
SurvivalCell Maturation, Cytokine Production, and The Tec Kinases Itk and Rlk Regulate NKT (2008) (0)
TCR signal strength via IRF4 influences CD8 T cell responses to acute LCMV infections (P6096) (2013) (0)
Differential requirement for IRF4 in CD8+ T cell responses to acute versus chronic LCMV infection (IRM4P.498) (2014) (0)
Faculty Opinions recommendation of Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells. (2014) (0)
Development of PLZF-expressing {gamma}{delta} NKT cells in Itk-/- mice (2012) (0)
Faculty Opinions recommendation of The critical role of LIGHT, a TNF family member, in T cell development. (2002) (0)
INTRAMOLECULAR ITK-PROLINE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE (1998) (0)
Cytotoxic effector CD4 T cells express NKG2C/E and are defined by a unique program dependent on Blimp-1. (IRC8P.482) (2014) (0)
TCF1 regulates antiviral T follicular helper (Tfh) cell responses through a negative feedback loop with IL-2 and Blimp1 (2016) (0)
Stimulates Aggregation and Apoptosis Tumor Cells Blocks Proliferation and 40-kDa Molecule on Fetal Thymocytes and A Monoclonal Antibody Reactive with a (1999) (0)
Chapter 13 Selection of an αβ T-Cell Antigen Receptor in Vivo and Expression in Vitro in a Soluble Form (1990) (0)
Selection of an αβ T Cell Antigen Receptor In Vivo and Engineering a Solulizable Form (1989) (0)
CD28-ITK signals regulate autoreactive T cell trafficking into tissues (123.41) (2012) (0)
Signaling in Naive T Cells Cutting Edge: Itk Is Not Essential for CD28 (2005) (0)
Faculty Opinions recommendation of CRK proteins selectively regulate T cell migration into inflamed tissues. (2015) (0)
Development of PLZF-expressing γδ NKT cells in Itk-/- mice (115.13) (2012) (0)
Cell cycle progression following naïve T cell activation is independent of Jak3/gc cytokine signals (97.6) (2009) (0)
Role of Itk in {gamma}{delta} T cell development and function (2008) (0)
The role of tec kinases in CD8+ T cell memory differentiation (2008) (0)
Janus Kinase 3- and CTLA-4-Deficient Mice Lead to Impaired T Cell Homeostasis in Cutting Edge: Two Distinct Mechanisms (2000) (0)
Development of CD4+ PLZF+ T Cells in the Absence of Itk (111.41) (2012) (0)
T Cell Development + CD 4 Do Not ImpedekMHC Class II Molecule I-E Alterations in CD 4-Binding Regions of the (1999) (0)
The intrinsic role of ROG in CD8+ T cell development has an impact on protective immunity against viral infection (P1452) (2013) (0)
Faculty Opinions recommendation of The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation. (2003) (0)
94 A Covalent Inhibitor of ITK and RLK Inhibits Th1 and Th17 Cell Differentiation and Prevents Disease Manifestation in an Adoptive Transfer Model of Colitis (2015) (0)
SignalingSelf-Association of Itk Enhances T Cell Disrupting the Intermolecular (2010) (0)
Regulation of B-lineage specification by the IL-7/JAK3/STAT5 pathway (83.6) (2007) (0)
The role of IRF4 in regulating effector CD8+ T cell development via repression of EOMES expression. (111.51) (2012) (0)
Alterations in CD 4 dependence accompany T cell development and differentiation (2005) (0)
Type I Diabetes induced by OT-I T-Cells requires ITK-mediated TCR signaling. (2022) (0)
Analysis of T-cell Receptor-Induced Calcium Influx in Primary Murine T-cells by Full Spectrum Flow Cytometry. (2022) (0)
Cells in Mice Lacking Jak3 A Profound Deficiency in Thymic Progenitor (2000) (0)
An essential role of ITK in T cell migration to the gut during mouse γ-herpesvirus 68 infection (2016) (0)
Regulation ofthepolarization ofT cells towardantigen- presenting cells byRas-related GTPaseCDC42 (cell polarity/cytoskeleton/actin/microtubules/cell-cell interactions) (1995) (0)
Faculty Opinions recommendation of Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes. (2003) (0)
Targeting of ITK-SYK fusion oncogene through in-silico generated and biologically validated ITK-PH domain modulators (2020) (0)
Absence of the Tec Kinase Itk Subtle Defects in Pre-TCR Signaling in the Berg (2007) (0)
Naive/Resting Required for IL-2 Synthesis by The Jak Family Tyrosine Kinase Jak3 Is (1999) (0)
Blimp-1 regulates CD8 T cell effector/memory development via regulation of cytokine receptor expression (110.20) (2012) (0)

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