Lewis C. Cantley

Q: What Schools Are Affiliated With Lewis C. Cantley

Lewis C. Cantley is affiliated with the following schools: Tufts University, Massachusetts General Hospital, Harvard University, Kumamoto University, Aristotle University of Thessaloniki, Sungkyunkwan University, Rockefeller University, University of California, San Diego, Cornell University, Weill Cornell Medicine, West Virginia Wesleyan College, University of Toronto, University of Ottawa, Yale University, Thomas Jefferson University, North Carolina State University, McGill University

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Lewis C. Cantley's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Papers

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation (2009) (11766)
AKT/PKB Signaling: Navigating Downstream (2007) (5517)
The phosphoinositide 3-kinase pathway. (2002) (5431)
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling (2007) (3501)
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate (2009) (3279)
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism (2006) (2946)
SH2 domains recognize specific phosphopeptide sequences (1993) (2610)
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth (2008) (2487)
Oncogenes and signal transduction (1991) (2472)
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. (1999) (2036)
Ras, PI(3)K and mTOR signalling controls tumour cell growth (2006) (2000)
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin (2005) (1878)
PI3K: Downstream AKTion Blocks Apoptosis (1997) (1771)
PI3K pathway alterations in cancer: variations on a theme (2008) (1765)
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. (2004) (1723)
Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs (2003) (1629)
Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate (1997) (1565)
The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity (1997) (1558)
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. (2002) (1526)
Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy (2009) (1486)
Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism (2012) (1470)
Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway (2013) (1408)
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. (2008) (1400)
Signalling through the lipid products of phosphoinositide-3-OH kinase (1997) (1398)
Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains (1997) (1386)
Targeting the PI3K-Akt pathway in human cancer: rationale and promise. (2003) (1370)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (2004) (1358)
Effective Use of PI3K and MEK Inhibitors to Treat Mutant K-Ras G12D and PIK3CA H1047R Murine Lung Cancers (2008) (1286)
The PI3K Pathway in Human Disease (2017) (1222)
Phosphoinositide kinases. (1998) (1177)
Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb (2003) (1172)
The LKB1 tumor suppressor negatively regulates mTOR signaling. (2004) (1077)
The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function* (1999) (1052)
Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals (1995) (978)
Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses (2011) (956)
Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate (1988) (929)
Pyruvate kinase M2 is a phosphotyrosine-binding protein (2008) (914)
Catalytic specificity of protein-tyrosine kinases is critical for selective signalling (1995) (913)
Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis (2011) (908)
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function (2014) (875)
Cancer metabolism: fatty acid oxidation in the limelight (2013) (831)
A colorectal cancer classification system that associates cellular phenotype and responses to therapy (2013) (828)
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling (2002) (814)
PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells (1989) (800)
Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. (1997) (781)
Phosphatidylinositol 3‐kinase (1994) (770)
Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle. (1977) (764)
Vascular Dysmorphogenesis Caused by an Activating Mutation in the Receptor Tyrosine Kinase TIE2 (1996) (746)
Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity. (1994) (740)
The Molecular Basis for Phosphodependent Substrate Targeting and Regulation of Plks by the Polo-Box Domain (2003) (732)
Distinct macrophage phenotypes contribute to kidney injury and repair. (2011) (705)
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion (2016) (701)
Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation (1985) (696)
Proteomic Screen Finds pSer/pThr-Binding Domain Localizing Plk1 to Mitotic Substrates (2003) (696)
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. (1999) (695)
Chromosomal instability drives metastasis through a cytosolic DNA response (2017) (691)
TAZ: a novel transcriptional co‐activator regulated by interactions with 14‐3‐3 and PDZ domain proteins (2000) (669)
Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth (2009) (668)
Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling (2011) (646)
A neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling (1994) (641)
Use of an oriented peptide library to determine the optimal substrates of protein kinases (1994) (629)
Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome (2014) (629)
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH (2015) (623)
The conserved phosphoinositide 3‐kinase pathway determines heart size in mice (2000) (622)
The PX domains of p47phox and p40phox bind to lipid products of PI(3)K (2001) (614)
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis (2012) (603)
Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation. (1986) (595)
Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. (1999) (584)
Determination of the Specific Substrate Sequence Motifs of Protein Kinase C Isozymes* (1997) (576)
ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor (1994) (561)
Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine. (2017) (558)
A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1 (1996) (557)
Bone marrow stem cells contribute to repair of the ischemically injured renal tubule. (2003) (549)
A motif-based profile scanning approach for genome-wide prediction of signaling pathways (2001) (547)
Targeting the PI3K signaling pathway in cancer. (2010) (540)
A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity (2002) (540)
Purification and characterization of phosphoinositide 3-kinase from rat liver. (1990) (533)
Akt/Protein Kinase B Promotes Organ Growth in Transgenic Mice (2002) (528)
ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines. (2005) (526)
Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation (2001) (526)
Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells (2010) (526)
Regulation of mTORC1 by PI3K signaling. (2015) (524)
Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity (1987) (518)
Determination of protease cleavage site motifs using mixture-based oriented peptide libraries (2001) (517)
Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3. (1994) (515)
Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation (2013) (503)
Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding. (1999) (500)
Rho Family GTPases Bind to Phosphoinositide Kinases (*) (1995) (494)
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. (2005) (487)
The PHD Finger of the Chromatin-Associated Protein ING2 Functions as a Nuclear Phosphoinositide Receptor (2003) (487)
A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains* (1997) (487)
NRF2 regulates serine biosynthesis in non-small cell lung cancer (2015) (483)
Stem cell metabolism in tissue development and aging (2013) (482)
Stromal cells protect against acute tubular injury via an endocrine effect. (2007) (478)
Rheb fills a GAP between TSC and TOR. (2003) (476)
Phosphatidylinositol‐3,4,5‐trisphosphate (PtdIns‐3,4,5‐P3)/Tec kinase‐dependent calcium signaling pathway: a target for SHIP‐mediated inhibitory signals (1998) (468)
The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4 (2013) (464)
Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer. (2006) (456)
A characterization of vanadate interactions with the (Na,K)-ATPase. Mechanistic and regulatory implications. (1978) (451)
A characterization of vanadate interactions with the (Na,K)-ATPase. Mechanistic and regulatory implications. (1978) (451)
AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. (2013) (449)
Activation of phosphatidylinositol 3-kinase by insulin. (1990) (449)
Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. (2009) (444)
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response (2012) (428)
Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase. (1997) (425)
A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate (1997) (424)
MicroRNA-Antagonism Regulates Breast Cancer Stemness and Metastasis via TET-Family-Dependent Chromatin Remodeling (2013) (415)
PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells (2013) (413)
High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. (2011) (406)
Peptide and Protein Library Screening Defines Optimal Substrate Motifs for AKT/PKB* (2000) (400)
The Crohn's Disease Protein, NOD2, Requires RIP2 in Order to Induce Ubiquitinylation of a Novel Site on NEMO (2004) (399)
Interleukin 3-dependent survival by the Akt protein kinase. (1997) (398)
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect (2012) (385)
The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. (2005) (376)
The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism (2010) (373)
Recognition and specificity in protein tyrosine kinase-mediated signalling. (1995) (372)
Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer. (2012) (371)
ras-transformed cells: altered levels of phosphatidylinositol-4,5-bisphosphate and catabolites. (1986) (367)
Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit. (1993) (362)
Lipid second messengers (1994) (362)
Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol. (1984) (357)
Metabolic flux and the regulation of mammalian cell growth. (2011) (356)
The erbB3 gene product is a receptor for heregulin. (1994) (353)
Vanadate inhibits the red cell (Na+, K+) ATPase from the cytoplasmic side (1978) (350)
Suppression of insulin feedback enhances the efficacy of PI3K inhibitors (2018) (349)
In vivo near-infrared fluorescence imaging of osteoblastic activity (2001) (349)
Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. (2009) (347)
Activation of Phospholipase C-γ by Phosphatidylinositol 3,4,5-Trisphosphate* (1998) (345)
Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State (2012) (339)
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. (2008) (338)
A rapid method for determining protein kinase phosphorylation specificity (2004) (336)
Heterogeneity of tumor-induced gene expression changes in the human metabolic network (2013) (336)
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. (2001) (329)
PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer. (2009) (321)
The Increasing Dominance of Teams in Production of Knowledge (2011) (320)
SRPK2: A Differentially Expressed SR Protein-specific Kinase Involved in Mediating the Interaction and Localization of Pre-mRNA Splicing Factors in Mammalian Cells (1998) (319)
Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation. (1993) (315)
Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α (2000) (311)
Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins (1995) (305)
Cell surface glypicans are low-affinity endostatin receptors. (2001) (305)
Biochemical Interactions Integrating Itk with the T Cell Receptor-initiated Signaling Cascade* (2000) (303)
Recovery of kidney function after acute kidney injury in the elderly: a systematic review and meta-analysis. (2008) (295)
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus (2014) (295)
T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif. (1994) (295)
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. (2012) (294)
Akt–RSK–S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases (2010) (292)
Molecular Balance between the Regulatory and Catalytic Subunits of Phosphoinositide 3-Kinase Regulates Cell Signaling and Survival (2002) (288)
Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells (1997) (284)
Lin28 Enhances Tissue Repair by Reprogramming Cellular Metabolism (2013) (281)
Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. (2006) (276)
Sequence requirements for the recognition of tyrosine‐based endocytic signals by clathrin AP‐2 complexes. (1996) (272)
Identification of SARS-CoV-2 Inhibitors using Lung and Colonic Organoids (2020) (271)
Structure and Mechanism of the (Na,K)-ATPase (1981) (270)
Diverse Biochemical Properties of Shp2 Mutants (2005) (267)
Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D. (1994) (267)
PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex. (2015) (265)
Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase (2007) (261)
Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. (1999) (260)
Signal transduction and membrane traffic: The PITP/phosphoinositide connection (1995) (259)
Metabolic pathway alterations that support cell proliferation. (2011) (259)
The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment (2018) (258)
Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts (1993) (257)
Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. (2010) (256)
Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. (2005) (255)
Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase (2001) (254)
Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. (2002) (253)
Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis (2014) (251)
Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton (2016) (249)
The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase (1989) (246)
The fate of cytoplasmic vanadium. Implications on (NA,K)-ATPase inhibition. (1979) (246)
Cancer Cell Metabolism (2012) (244)
Phosphoinositide 3-kinase in immunological systems. (2002) (243)
Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size. (2011) (243)
Type Iα phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly (2000) (242)
Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1. (2008) (239)
Protein Sequences from Mastodon and Tyrannosaurus Rex Revealed by Mass Spectrometry (2007) (239)
The SH3 Domain of Amphiphysin Binds the Proline-rich Domain of Dynamin at a Single Site That Defines a New SH3 Binding Consensus Sequence* (1997) (238)
Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx (1985) (238)
Glutathione reduces cytoplasmic vanadate. Mechanism and physiological implications. (1980) (233)
Regulatory interactions in the recognition of endocytic sorting signals by AP‐2 complexes (1997) (232)
Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations. (2005) (230)
Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis. (2004) (229)
Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase. (1992) (229)
The Cbl Phosphotyrosine-binding Domain Selects a D(N/D)XpY Motif and Binds to the Tyr292Negative Regulatory Phosphorylation Site of ZAP-70* (1997) (228)
mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. (2011) (228)
The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase. (1991) (227)
Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation. (2009) (227)
Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis. (2003) (227)
Conditional Inhibition of the Mitogen-activated Protein Kinase Cascade by Wortmannin (1997) (227)
Identification of small molecule inhibitors of pyruvate kinase M2. (2010) (226)
p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake. (2012) (225)
Isolation of a potent (Na-K)ATPase inhibitor from striated muscle. (1977) (224)
A label‐free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen (2008) (222)
United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling. (2003) (220)
Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. (2011) (220)
Use of RNA Interference-mediated Gene Silencing and Adenoviral Overexpression to Elucidate the Roles of AKT/Protein Kinase B Isoforms in Insulin Actions* (2003) (219)
MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. (2017) (216)
Phosphoinositide 3-Kinase Regulates Phospholipase Cγ-mediated Calcium Signaling* (1998) (214)
Phosphoinositide 3-Kinase Regulates Phospholipase Cγ-mediated Calcium Signaling* (1998) (214)
A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-Specific Inhibitor, with Letrozole in ER+/HER2− Metastatic Breast Cancer (2016) (212)
PtdIns(5)P activates the host cell PI3‐kinase/Akt pathway during Shigella flexneri infection (2006) (212)
Class IA Phosphoinositide 3-Kinase Regulates Heart Size and Physiological Cardiac Hypertrophy (2005) (212)
Regulation of c-Src tyrosine kinase activity by the Src SH2 domain. (1993) (210)
The C2 Domain of PKCδ Is a Phosphotyrosine Binding Domain (2005) (210)
Clathrin-coated vesicles contain an ATP-dependent proton pump. (1983) (209)
A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity (1993) (207)
Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation. (1987) (206)
Biomolecular Characterization and Protein Sequences of the Campanian Hadrosaur B. canadensis (2009) (206)
Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants (1991) (202)
Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2 (2013) (201)
Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis. (2006) (200)
PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice (2010) (200)
Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers. (2011) (200)
The Inositol 5′-Phosphatase SHIP Binds to Immunoreceptor Signaling Motifs and Responds to High Affinity IgE Receptor Aggregation* (1996) (200)
Granulocyte macrophage‐colony stimulating factor stimulates both association and activation of phosphoinositide 3OH‐kinase and src‐related tyrosine kinase(s) in human myeloid derived cells. (1993) (199)
The SH3 Domain-binding T Cell Tyrosyl Phosphoprotein p120 (1995) (197)
Corequirement of Specific Phosphoinositides and Small GTP-binding Protein Cdc42 in Inducing Actin Assembly in Xenopus Egg Extracts (1998) (197)
Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. (2009) (197)
Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. (1997) (196)
Apoptosis: A Bad kinase makes good (1997) (196)
Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival (2011) (195)
Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. (2013) (193)
SYK Is Upstream of Phosphoinositide 3-Kinase in B Cell Receptor Signaling* (1999) (192)
Phenformin enhances the therapeutic benefit of BRAFV600E inhibition in melanoma (2013) (191)
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate (2010) (189)
SH2 domain specificity and activity modified by a single residue (1994) (187)
PtdIns(4,5)P2 Functions at the Cleavage Furrow during Cytokinesis (2005) (186)
Utilization of Oriented Peptide Libraries to Identify Substrate Motifs Selected by ATM* (2000) (185)
Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer (2015) (185)
Phosphoinositide 3-Kinase Catalytic Subunit Deletion and Regulatory Subunit Deletion Have Opposite Effects on Insulin Sensitivity in Mice (2005) (183)
Subcellular Locations of Phosphatidylinositol 4-Kinase Isoforms* (1997) (182)
Activation of P2Y2 Receptors by UTP and ATP Stimulates Mitogen-activated Kinase Activity through a Pathway That Involves Related Adhesion Focal Tyrosine Kinase and Protein Kinase C* (1998) (182)
The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor (2004) (182)
Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain. (1989) (180)
Coordinated Regulation of Toll-Like Receptor and NOD2 Signaling by K63-Linked Polyubiquitin Chains (2007) (180)
Macrophages promote cyst growth in polycystic kidney disease. (2011) (177)
Macrophages in Renal Injury and Repair. (2017) (177)
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers (2016) (177)
Targeting cancer vulnerabilities with high-dose vitamin C (2019) (173)
Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. (2013) (172)
Hem-1 Complexes Are Essential for Rac Activation, Actin Polymerization, and Myosin Regulation during Neutrophil Chemotaxis (2006) (171)
The Phosphotyrosine Interaction Domain of SHC Recognizes Tyrosine-phosphorylated NPXY Motif (*) (1995) (169)
Phosphatidylinositol metabolism and polyoma-mediated transformation. (1986) (168)
Hepatocyte Growth Factor Induces ERK-dependent Paxillin Phosphorylation and Regulates Paxillin-Focal Adhesion Kinase Association* (2002) (168)
Cloning and Characterization of a Wortmannin-sensitive Human Phosphatidylinositol 4-Kinase* (1997) (167)
Obesity and Cancer Mechanisms: Cancer Metabolism. (2016) (167)
Expression of Neutrophil Gelatinase-associated Lipocalin Regulates Epithelial Morphogenesis in Vitro* (2005) (167)
Glutathione biosynthesis is a metabolic vulnerability in PI3K/Akt-driven breast cancer (2016) (166)
Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells. (1993) (165)
Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3' kinase complexes: potential interactions with the microtubule cytoskeleton (1993) (164)
High-fructose corn syrup enhances intestinal tumor growth in mice (2019) (164)
Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation. (1998) (162)
A Multi-enzyme Cascade of Hemoglobin Proteolysis in the Intestine of Blood-feeding Hookworms* (2004) (162)
Characterization of a Rac1- and RhoGDI-Associated Lipid Kinase Signaling Complex (1998) (157)
p120 Is a Major Substrate of Tyrosine Phosphorylation upon B Cell Antigen Receptor Stimulation and Interacts in Vivo with Fyn and Syk Tyrosine Kinases, Grb2 and Shc Adaptors, and the p85 Subunit of Phosphatidylinositol 3-Kinase (*) (1996) (156)
Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation (2003) (154)
Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors (2011) (154)
Stand up to cancer phase Ib study of pan-phosphoinositide-3-kinase inhibitor buparlisib with letrozole in estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer. (2014) (153)
Regulation of GRP1-catalyzed ADP Ribosylation Factor Guanine Nucleotide Exchange by Phosphatidylinositol 3,4,5-Trisphosphate* (1998) (152)
p120 Is a Cytosolic Adapter Protein That Associates with Phosphoinositide 3-Kinase in Response to Epidermal Growth Factor in PC12 and Other Cells (*) (1996) (152)
Phosphoinositide 3-kinase regulatory subunit p85α suppresses insulin action via positive regulation of PTEN (2006) (152)
The impact of aging on kidney repair. (2008) (151)
The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex (2005) (150)
Phase I dose escalation study of the PI3kinase pathway inhibitor BKM120 and the oral poly (ADP ribose) polymerase (PARP) inhibitor olaparib for the treatment of high-grade serous ovarian and breast cancer (2016) (150)
Phosphoinositide kinases. (1990) (149)
Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase (1993) (149)
Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer. (2018) (149)
Heregulin Stimulates Mitogenesis and Phosphatidylinositol 3-Kinase in Mouse Fibroblasts Transfected with erbB2/neu and erbB3(*) (1995) (148)
Evidence that a Na+/Ca2+ antiport system regulates murine erythroleukemia cell differentiation. (1982) (147)
Small molecule activation of PKM2 in cancer cells induces serine auxotrophy. (2012) (147)
Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange. (1984) (147)
ERK Negatively Regulates the Epidermal Growth Factor-mediated Interaction of Gab1 and the Phosphatidylinositol 3-Kinase* (2002) (146)
Increased P85α Is a Potent Negative Regulator of Skeletal Muscle Insulin Signaling and Induces in Vivo Insulin Resistance Associated with Growth Hormone Excess* (2005) (146)
Role of endothelin and prostaglandins in radiocontrast-induced renal artery constriction. (1993) (145)
Altered metabolism in cancer (2010) (145)
Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity (1996) (143)
Depletion of a Putatively Druggable Class of Phosphatidylinositol Kinases Inhibits Growth of p53-Null Tumors (2013) (143)
Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase. (1994) (142)
Differential Effects of Gefitinib and Cetuximab on Non–small-cell Lung Cancers Bearing Epidermal Growth Factor Receptor Mutations (2005) (141)
The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C* (1997) (141)
Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. (2010) (141)
The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C* (1997) (141)
Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation. (1991) (139)
Role of Phosphoinositide 3-Kinase Regulatory Isoforms in Development and Actin Rearrangement (2005) (139)
Phosphoinositide metabolism and the control of cell proliferation. (1989) (138)
IκB Kinase β Phosphorylates the K63 Deubiquitinase A20 To Cause Feedback Inhibition of the NF-κB Pathway (2007) (138)
Phosphoinositide Binding Domains Embracing 3-Phosphate (1999) (136)
Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling* (2003) (136)
Identification of small molecule inhibitors of anthrax lethal factor (2004) (134)
The C2 domain of PKCdelta is a phosphotyrosine binding domain. (2005) (133)
A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer (2013) (133)
Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression (1994) (133)
Growth Factor-specific Signaling Pathway Stimulation and Gene Expression Mediated by ErbB Receptors* 210 (2001) (132)
What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway. (2013) (132)
Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen‐activated protein Kinase (MAPK) and Phosphatidylinositol‐3‐kinase (PI3K)/AKT pathways (2012) (132)
D3 Phosphoinositides and Outside-in integrin Signaling by Glycoprotein IIb-IIIa Mediate Platelet Actin Assembly and Filopodial Extension Induced by Phorbol 12-Myristate 13-Acetate* (1996) (130)
Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors (2019) (129)
Phosphoinositide 3-kinase and the regulation of cell growth. (1996) (128)
Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer. (2016) (128)
Interleukin-2 receptor regulates activation of phosphatidylinositol 3-kinase. (1991) (127)
A fluorescent reporter of AMPK activity and cellular energy stress. (2011) (127)
Interferon regulatory factor-3 is an in vivo target of DNA-PK (2002) (126)
Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin. (2017) (125)
Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial. (2019) (125)
Type I Phosphatidylinositol-4-phosphate 5-Kinases Synthesize the Novel Lipids Phosphatidylinositol 3,5-Bisphosphate and Phosphatidylinositol 5-Phosphate* (1998) (125)
Overview of the Alliance for Cellular Signaling (2002) (125)
Structural aspects of the red cell anion exchange protein. (1986) (125)
A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics. (2015) (121)
Macrophage-mediated injury and repair after ischemic kidney injury (2015) (121)
Binding Specificity and Regulation of the Serine Protease and PDZ Domains of HtrA2/Omi* (2003) (121)
Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis. (2001) (120)
Regulation of mitogenesis, motogenesis, and tubulogenesis by hepatocyte growth factor in renal collecting duct cells. (1994) (120)
Ligand Discrimination in Signaling through an ErbB4 Receptor Homodimer* (2000) (119)
The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation (2003) (119)
Adult stem cells in the repair of the injured renal tubule (2005) (119)
Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling (2017) (119)
Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation. (2013) (118)
The APL paradigm and the "co-clinical trial" project. (2011) (117)
Marked Differences between Metalloproteases Meprin A and B in Substrate and Peptide Bond Specificity* (2001) (117)
Diverting Glycolysis to Combat Oxidative Stress (2015) (114)
Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain. (2015) (114)
PHGDH amplification and altered glucose metabolism in human melanoma (2011) (114)
Rapid release of bound glucose-6-phosphate dehydrogenase by growth factors. Correlation with increased enzymatic activity. (1991) (113)
Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit. (1996) (112)
The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling. (2010) (112)
Hitting the Target: Emerging Technologies in the Search for Kinase Substrates (2002) (111)
Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. (2013) (111)
Increased Insulin Sensitivity and Reduced Adiposity in Phosphatidylinositol 5-Phosphate 4-Kinase β−/− Mice (2004) (111)
Fetal Deficiency of Lin28 Programs Life‐Long Aberrations in Growth and Glucose Metabolism (2013) (110)
FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells (2013) (109)
Deletion of the phosphoinositide 3-kinase p110γ gene attenuates murine atherosclerosis (2007) (107)
Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia. (2006) (107)
Cancer's Fuel Choice: New Flavors for a Picky Eater. (2015) (106)
Lipopolysaccharide and phorbol esters induce differentiation but have opposite effects on phosphatidylinositol turnover and Ca2+ mobilization in 70Z/3 pre-B lymphocytes. (1985) (106)
Bone marrow plasticity revisited: protection or differentiation in the kidney tubule? (2005) (106)
A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. (1996) (106)
MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. (2017) (106)
Phosphatidylinositol 4,5-Bisphosphate Synthesis Is Required for Activation of Phospholipase D in U937 Cells (*) (1995) (106)
Structural Organization and Alternative Splicing of the Murine Phosphoinositide 3-Kinase p85α Gene (1996) (105)
Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation (2019) (104)
Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphology (2009) (104)
Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. (2010) (104)
EGF receptor ligands are a large fraction of in vitro branching morphogens secreted by embryonic kidney. (1997) (103)
Differential MAPK Pathways Utilized for HGF- and EGF-dependent Renal Epithelial Morphogenesis* (2001) (102)
Characterization of KRAS rearrangements in metastatic prostate cancer. (2011) (102)
Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling. (2003) (102)
Cell-to-Cell Variability in PI3K Protein Level Regulates PI3K-AKT Pathway Activity in Cell Populations (2011) (101)
Phosphoinositide 3-Kinase Binds Constitutively to α/β-Tubulin and Binds to γ-Tubulin in Response to Insulin (*) (1995) (101)
Class 1A PI3K regulates vessel integrity during development and tumorigenesis (2008) (100)
Specificity of LIM Domain Interactions with Receptor Tyrosine Kinases* (1996) (98)
Extracellular ATP increases free cytosolic calcium in rat parotid acinar cells. Differences from phospholipase C-linked receptor agonists. (1988) (97)
Bovine brain contains two types of phosphatidylinositol kinase. (1987) (97)
Phosphatidylinositol 3-kinase and its novel product, phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae. (1989) (96)
Association of Protein Kinase Cμ with Type II Phosphatidylinositol 4-Kinase and Type I Phosphatidylinositol-4-phosphate 5-Kinase* (1998) (96)
Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin (2010) (96)
Mitogens and ion fluxes. (1988) (96)
Amiloride inhibits murine erythroleukemia cell differentiation: evidence for a Ca2+ requirement for commitment. (1980) (96)
Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms. (2010) (95)
Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone (2015) (95)
Site–Specific Monoubiquitination Activates Ras by Impeding GTPase Activating Protein Function (2012) (95)
Par3 functions in the biogenesis of the primary cilium in polarized epithelial cells (2007) (94)
Characterization of nucleotide binding sites on chloroplast coupling factor 1. (1975) (93)
The active site structure of Na+- and K+-stimulated ATPase. Location of a specific fluorescein isothiocyanate reactive site. (1982) (93)
Location of the stilbenedisulfonate binding site of the human erythrocyte anion-exchange system by resonance energy transfer. (1979) (93)
Phosphatidylinositol-3 kinase activation induced upon Fc gamma RIIIA- ligand interaction (1994) (91)
T Cell Activation-dependent Association between the p85 Subunit of the Phosphatidylinositol 3-Kinase and Grb2/Phospholipase C-γ1-binding Phosphotyrosyl Protein pp36/38 (*) (1995) (91)
Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids (2020) (91)
Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud (2001) (91)
EphA kinase activation regulates HGF-induced epithelial branching morphogenesis (2003) (91)
A study of the vanadate-trapped state of the (Na,K)-ATPase. Evidence against interacting nucleotide site models. (1980) (90)
Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C. (1988) (90)
Insulin–PI3K signalling: an evolutionarily insulated metabolic driver of cancer (2020) (90)
Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations (2011) (90)
The Role of the ErbB Family Members in Non–Small Cell Lung Cancers Sensitive to Epidermal Growth Factor Receptor Kinase Inhibitors (2006) (90)
Chitinase-like protein Brp-39/YKL-40 modulates the renal response to ischemic injury and predicts delayed allograft function. (2013) (89)
HGF-mediated chemotaxis and tubulogenesis require activation of the phosphatidylinositol 3-kinase. (1995) (89)
Rapidly Proliferating Cells Evidence for an Alternative Glycolytic Pathway in (2010) (89)
A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast (2004) (88)
Pathological Role of Serum- and Glucocorticoid-Regulated Kinase 1 in Adverse Ventricular Remodeling (2012) (88)
Extracellular HIV‐1 Tat protein activates phosphatidylinositol 3‐ and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells (1997) (87)
PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation (2017) (87)
GM-CSF Promotes Macrophage Alternative Activation after Renal Ischemia/Reperfusion Injury. (2015) (87)
Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity. (2017) (86)
Pathways for phosphoinositide synthesis. (1999) (85)
Differential Signaling by the Epidermal Growth Factor-like Growth Factors Neuregulin-1 and Neuregulin-2* (1998) (85)
Cellular maintenance and repair of the kidney. (2010) (85)
Signals Which Build a Tubule (2005) (85)
IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway. (2007) (84)
Impaired Kit- but Not FcεRI-initiated Mast Cell Activation in the Absence of Phosphoinositide 3-Kinase p85α Gene Products* (2000) (84)
Zag expression during aging suppresses proliferation after kidney injury. (2008) (84)
Metabolomics of Human Cerebrospinal Fluid Identifies Signatures of Malignant Glioma* (2012) (84)
Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons. (2012) (84)
A Single Point Mutation Switches the Specificity of Group III Src Homology (SH) 2 Domains to That of Group I SH2 Domains (*) (1995) (84)
Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. (2009) (83)
Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo (2007) (82)
Effects of extracellular ATP on ion transport systems and [Ca2+]i in rat parotid acinar cells. Comparison with the muscarinic agonist carbachol (1990) (82)
Effects of muscarinic, alpha-adrenergic, and substance P agonists and ionomycin on ion transport mechanisms in the rat parotid acinar cell. The dependence of ion transport on intracellular calcium (1989) (82)
Epithelial–mesenchymal–epithelial cycling in kidney repair (2008) (81)
Norepinephrine complexes and reduced vanadium(V) to reverse vanadate inhibition of the (sodium, potassium ion)-dependent ATPase (1978) (80)
Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition. (2020) (80)
Extracellular Human Immunodeficiency Virus Type-1 Tat Protein Activates Phosphatidylinositol 3-Kinase in PC12 Neuronal Cells* (1996) (80)
Regulation of the Lck SH2 Domain by Tyrosine Phosphorylation* (1996) (80)
Cloning and characterization of a human phosphatidylinositol 4-kinase. (1994) (80)
Reactive Oxygen Species Expose Cryptic Epitopes Associated with Autoimmune Goodpasture Syndrome* (2000) (79)
Then Negative Regulation of Phosphoinositide 3-Kinase Signaling by p85 and Its Implication in Cancer (2005) (79)
Production of novel polyphosphoinositides in vivo is linked to cell transformation by polyomavirus middle T antigen (1990) (79)
Characterization and purification of membrane-associated phosphatidylinositol-4-phosphate kinase from human red blood cells. (1989) (77)
The p85α Regulatory Subunit of Phosphoinositide 3-Kinase Potentiates c-Jun N-Terminal Kinase-Mediated Insulin Resistance (2007) (77)
Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85α Src homology-2 domains (2011) (77)
Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis. (2007) (76)
The negative regulation of phosphoinositide 3-kinase signaling by p85 and it's implication in cancer. (2005) (76)
Signal transduction: Grabbing phosphoproteins (1999) (75)
Role of mitochondrial membrane potential in the regulation of murine erythroleukemia cell differentiation (1982) (75)
AMP-Activated Protein Kinase Regulates Neuronal Polarization by Interfering with PI 3-Kinase Localization (2011) (75)
The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells. (2002) (75)
Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition. (2014) (74)
Calcium regulates the commitment of murine erythroleukemia cells to terminal erythroid differentiation (1981) (74)
Idelalisib--a PI3Kδ inhibitor for B-cell cancers. (2014) (73)
Differential regulation of the phosphoinositide 3-kinase and MAP kinase pathways by hepatocyte growth factor vs. insulin-like growth factor-I in myogenic cells. (2004) (73)
Determining protein kinase substrate specificity by parallel solution-phase assay of large numbers of peptide substrates (2006) (73)
DNA Damage-induced Association of ATM with Its Target Proteins Requires a Protein Interaction Domain in the N Terminus of ATM* (2005) (73)
Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer (2010) (72)
The SH2 Domain-containing Inositol 5′-Phosphatase (SHIP) Recruits the p85 Subunit of Phosphoinositide 3-Kinase during FcγRIIb1-mediated Inhibition of B Cell Receptor Signaling* (1999) (71)
PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition. (2017) (71)
Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins (1998) (71)
Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase (2006) (71)
Extracellular ATP induces ion fluxes and inhibits growth of Friend erythroleukemia cells. (1984) (71)
Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins. (1995) (71)
Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance (2013) (71)
Fenofibrate prevents skeletal muscle loss in mice with lung cancer (2018) (70)
Phosphorylation of the Platelet p47 Phosphoprotein Is Mediated by the Lipid Products of Phosphoinositide 3-Kinase (*) (1995) (70)
Mesenchymal-Epithelial Transition in epithelial response to injury: the role of Foxc2 (2009) (69)
Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet. (2015) (69)
Fluorescence energy transfer between ligand binding sites on chloroplast coupling factor 1. (1975) (68)
Microarray analysis of in vitro pericyte differentiation reveals an angiogenic program of gene expression (2005) (67)
ERK Regulates the Hepatocyte Growth Factor-mediated Interaction of Gab1 and the Phosphatidylinositol 3-Kinase* (2001) (67)
Regional expression of hepatocyte growth factor/c-met in experimental renal hypertrophy and hyperplasia. (1994) (66)
p85α SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation. (2012) (66)
High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif. (1997) (66)
Association of Urinary Biomarkers of Inflammation, Injury, and Fibrosis with Renal Function Decline: The ACCORD Trial. (2016) (65)
Specificity in recognition of phosphopeptides by src-homology 2 domains (1994) (65)
Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling. (1998) (65)
BRD7, a tumor suppressor, interacts with p85α and regulates PI3K activity. (2014) (65)
Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling. (1998) (65)
Stimulation of the T3-T cell receptor-associated Ca2+ influx enhances the activity of the Na+/H+ exchanger in a leukemic human T cell line. (1985) (65)
Reaction of (Na-K)ATPase with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole: evidence for an essential tyrosine at the active site. (1978) (64)
Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion (2016) (64)
Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis. (2019) (62)
Peptide Substrate Specificities and Protein Cleavage Sites of Human Endometase/Matrilysin-2/Matrix Metalloproteinase-26* (2002) (62)
Toward a better understanding of folate metabolism in health and disease (2018) (62)
An 11-Amino Acid Sequence from c-met Initiates Epithelial Chemotaxis via Phosphatidylinositol 3-Kinase and Phospholipase C (*) (1996) (61)
Breathless cancer cells get fat on glutamine (2012) (61)
Transformation-defective mutants of polyomavirus middle T antigen associate with phosphatidylinositol 3-kinase (PI 3-kinase) but are unable to maintain wild-type levels of PI 3-kinase products in intact cells (1992) (61)
Two distinct cytosolic calcium responses to extracellular ATP in rat parotid acinar cells (1993) (61)
T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling. (2007) (61)
Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients (2013) (60)
Vascular Endothelial Growth Factor Induces Branching Morphogenesis/Tubulogenesis in Renal Epithelial Cells in a Neuropilin-Dependent Fashion (2005) (60)
Searching for genes that matter in acute kidney injury: a systematic review. (2009) (60)
Chemoprevention Meets Glucose Control (2010) (59)
Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells (2018) (59)
Macrophage-specific deletion of transforming growth factor-β1 does not prevent renal fibrosis after severe ischemia-reperfusion or obstructive injury. (2013) (59)
PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α (2017) (58)
Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn (1994) (58)
FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS. (2021) (57)
A constitutively activated form of the p110β isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice (2010) (57)
Investigation of quercetin binding sites on chloroplast coupling factor 1. (1976) (57)
Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro. (1992) (57)
Activation of beef heart mitochondrial adenosine triphosphatase by 2,4-dinitrophenol. (1973) (57)
Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9 (2013) (57)
Increasing the intracellular Na+ concentration induces differentiation in a pre-B lymphocyte cell line. (1983) (56)
Response to Comment on "Protein Sequences from Mastodon and Tyrannosaurus rex Revealed by Mass Spectrometry" (2008) (56)
Hypothalamic factor inhibits the (Na,K)ATPase from the extracellular surface. Mechanism of inhibition. (1985) (56)
AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo. (2007) (55)
Cell Confluence Regulates Hepatocyte Growth Factor-Stimulated Cell Morphogenesis in a β-Catenin-Dependent Manner (2006) (55)
Novel polyphosphoinositides in cell growth and activation. (1991) (55)
Molecular Phylogenetics of Mastodon and Tyrannosaurus rex (2008) (55)
Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival (2016) (54)
2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. (2011) (54)
Increased tubular proliferation as an adaptive response to glomerular albuminuria. (2012) (53)
Interactions between transport inhibitors at the anion binding sites of the band 3 dimer. (1981) (53)
Metabolic syndrome: F stands for fructose and fat (2013) (53)
Tubular GM-CSF Promotes Late MCP-1/CCR2-Mediated Fibrosis and Inflammation after Ischemia/Reperfusion Injury. (2019) (53)
Dietary fructose improves intestinal cell survival and nutrient absorption. (2021) (52)
BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K. (2014) (52)
1,25(OH)2D3 increases calcium and phosphatidylinositol metabolism in differentiating cultured human keratinocytes. (1990) (52)
Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis. (2019) (52)
Polycystin-2 Regulates Proliferation and Branching Morphogenesis in Kidney Epithelial Cells* (2006) (51)
Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase. (2005) (50)
Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. (2018) (50)
Hypothalamic sodium-transport inhibitor is a high-affinity reversible inhibitor of Na+-K+-ATPase. (1984) (50)
Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin. (1995) (50)
Mcp1 Promotes Macrophage-Dependent Cyst Expansion in Autosomal Dominant Polycystic Kidney Disease. (2018) (50)
A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition. (2014) (49)
Erythropoietin expands a stromal cell population that can mediate renoprotection. (2008) (49)
Blockade of ATP binding site of P2 purinoceptors in rat parotid acinar cells by isothiocyanate compounds. (1993) (49)
The use of peptide library for the determination of kinase peptide substrates. (1998) (49)
A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. (2018) (49)
Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer. (2017) (48)
Evidence that inhibitors of anion exchange induce a transmembrane conformational change in band 3. (1983) (48)
Somatic Mutations of PIK3R1 Promote Gliomagenesis (2012) (48)
The Polycystin 1-C-terminal Fragment Stimulates ERK-dependent Spreading of Renal Epithelial Cells* (2006) (47)
Induction of heat-shock proteins does not prevent renal tubular injury following ischemia. (1995) (47)
PTEN loss is a context‐dependent outcome determinant in obese and non‐obese endometrioid endometrial cancer patients (2015) (46)
Cancer's insatiable appetite (2009) (46)
Protein Tyrosine Phosphatase 1B Regulates Pyruvate Kinase M2 Tyrosine Phosphorylation* (2013) (46)
Neutrophil gelatinase-associated lipocalin suppresses cyst growth by Pkd1 null cells in vitro and in vivo. (2008) (46)
Minimal activators that bind to the KIX domain of p300/CBP identified by phage display screening (2000) (45)
Organ‐specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene‐targeting of the PI3K regulatory isoforms p85α, p55α, and p50α (2009) (45)
A monoclonal antibody distinguishes two types of phosphatidylinositol 4-kinase. (1991) (45)
Mechanism of anion exchange across the red cell membrane by band 3: interactions between stilbenedisulfonate and NAP-taurine binding sites. (1981) (45)
Activated ERK2 Interacts with and Phosphorylates the Docking Protein GAB1* (1999) (44)
Altered Signaling and Cell Cycle Regulation in Embryonal Stem Cells with a Disruption of the Gene for Phosphoinositide 3-Kinase Regulatory Subunit p85α* (2003) (44)
TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development. (2011) (44)
The carbohydrate-insulin model: a physiological perspective on the obesity pandemic (2021) (43)
Elevation of [Ca2+]i and the Activation of Ion Channels and Fluxes by Extracellular ATP and Phospholipase C‐Linked Agonists in Rat Parotid Acinar Cells (1990) (43)
YKL-40 Associates with Renal Recovery in Deceased Donor Kidney Transplantation. (2017) (43)
A sweet new role for EGFR in cancer. (2008) (43)
Extracellular ATP elevates intracellular free calcium in rat parotid acinar cells. (1987) (42)
Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system (2016) (42)
A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. (2000) (42)
Phosphorylation by LAMMER protein kinases: determination of a consensus site, identification of in vitro substrates, and implications for substrate preferences. (2002) (42)
Interpreting Sequences from Mastodon and T. rex (2007) (42)
Hepatocyte Growth Factor-Mediated Renal Epithelial Branching Morphogenesis Is Regulated by Glypican-4 Expression (2004) (42)
NRF 2 regulates serine biosynthesis in non-small cell lung cancer (2016) (41)
A Homogeneous, High-Throughput Assay for Phosphatidylinositol 5-Phosphate 4-Kinase with a Novel, Rapid Substrate Preparation (2013) (41)
Characterization of the ATP-dependent proton pump of clathrin-coated vesicles. (1984) (41)
A novel pathway for the formation of phosphatidylinositol 3,4-bisphosphate. Phosphorylation of phosphatidylinositol 3-monophosphate by phosphatidylinositol-3-monophosphate 4-kinase. (1990) (41)
Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene. (1996) (40)
Association of phosphatidylinositol 3-kinase, via the SH2 domains of p85, with focal adhesion kinase in polyoma middle t-transformed fibroblasts. (1996) (40)
Acetate Fuels the Cancer Engine (2014) (39)
Signal transduction by the hepatocyte growth factor receptor, c-met. Activation of the phosphatidylinositol 3-kinase. (1995) (39)
Building a human kinase gene repository: bioinformatics, molecular cloning, and functional validation. (2005) (39)
Age-induced accumulation of methylmalonic acid promotes tumour progression (2020) (39)
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. (2019) (39)
Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation. (1999) (39)
Signal transduction by the hepatocyte growth factor receptor, c-met. Activation of the phosphatidylinositol 3-kinase. (1995) (39)
MMP-20 is predominately a tooth-specific enzyme with a deep catalytic pocket that hydrolyzes type V collagen. (2006) (39)
SH2 domain specificity determination using oriented phosphopeptide library. (1995) (38)
The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study (2021) (38)
Delta endotoxin is a potent inhibitor of the (Na,K)-ATPase. (1986) (38)
Human pluripotent stem cells decouple respiration from energy production (2011) (37)
Phase I study of oral BKM120 and oral olaparib for high-grade serous ovarian cancer (HGSC) or triple-negative breast cancer (TNBC). (2014) (37)
The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility (2012) (36)
Growth factors and the kidney: regulation of epithelial cell movement and morphogenesis. (1996) (36)
Extracellular HIV-1 Tat Protein Induces a Rapid and Selective Activation of Protein Kinase C (PKC)-α, -ϵ, and -ζ Isoforms in PC12 Cells (1998) (36)
Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin. (1991) (36)
Biomarkers of inflammation and repair in kidney disease progression. (2020) (35)
Genetic selection for enhanced serine metabolism in cancer development (2011) (35)
Impaired kit- but not FcepsilonRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85alpha gene products. (2000) (35)
Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription (2020) (35)
Phosphorylation of the (Na,K)-ATPase by a plasma membrane-bound protein kinase in friend erythroleukemia cells. (1983) (35)
Deletion of the Met receptor in the collecting duct decreases renal repair following ureteral obstruction. (2009) (35)
α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH). (2017) (35)
A Cross-Species Study of PI3K Protein-Protein Interactions Reveals the Direct Interaction of P85 and SHP2 (2016) (35)
Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death (2017) (34)
Expression of an ouabain-resistant Na,K-ATPase in CV-1 cells after transfection with a cDNA encoding the rat Na,K-ATPase alpha 1 subunit. (1988) (34)
The Structure and Function of Band 3 (1983) (34)
Human erythrocyte anion exchange site characterised using a fluorescent probe (1979) (34)
EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src (2015) (34)
A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase. (2000) (34)
Peptide libraries: at the crossroads of proteomics and bioinformatics. (2003) (34)
PI3K Charges Ahead (2007) (34)
Acetate Fuels the Cancer Engine (2015) (34)
Phase 2 study of buparlisib (BKM120), a pan-class I PI3K inhibitor, in patients with metastatic triple-negative breast cancer (2020) (34)
Adjudication of etiology of acute kidney injury: experience from the TRIBE-AKI multi-center study (2014) (33)
Purification and characterization of human erythrocyte phosphatidylinositol 4-kinase. Phosphatidylinositol 4-kinase and phosphatidylinositol 3-monophosphate 4-kinase are distinct enzymes. (1992) (33)
Erratum: MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer (Cancer Cell (2017) 32(1) (71–87.e7) (S1535610817302544) (10.1016/j.ccell.2017.06.004)) (2017) (33)
AACR Cancer Progress Report 2012 (2012) (33)
Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries. (2000) (33)
A Fundamental Trade-off in Covalent Switching and Its Circumvention by Enzyme Bifunctionality in Glucose Homeostasis* (2014) (33)
In-Gel Stable-Isotope Labeling (ISIL): a strategy for mass spectrometry-based relative quantification. (2006) (32)
Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice (2012) (32)
Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells. (2019) (32)
Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε (2012) (32)
Development of a 2-dimensional atlas of the human kidney with imaging mass cytometry. (2019) (31)
Active Pin 1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer (2015) (31)
Targeting a Common Collaborator in Cancer Development (2010) (31)
Urine YKL-40 is associated with progressive acute kidney injury or death in hospitalized patients (2014) (31)
Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer (2019) (31)
Characterization of sulfhydryl groups on chloroplast coupling factor 1 exposed by heat activation. (1976) (30)
Covalent reactions of wortmannin under physiological conditions. (2007) (30)
Vanadium stimulates the (Na+,K+) pump in friend erythroleukemia cells and blocks erythropoiesis (1983) (30)
Prioritization schema for immunotherapy clinical trials in glioblastoma (2016) (30)
Rewiring of glycolysis in cancer cell metabolism (2010) (29)
Cancer metabolism gets physical (2018) (29)
The chemokine KC regulates HGF-stimulated epithelial cell morphogenesis. (2004) (29)
Pyruvate kinase M2 is a phosphotyrosine (2008) (29)
Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation. (2017) (28)
Biomarkers of Acute Kidney Injury (2007) (28)
AACR Cancer Progress Report 2015 (2015) (28)
Characterization of PXK as a Protein Involved in Epidermal Growth Factor Receptor Trafficking (2010) (27)
The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro (2020) (27)
Casein Kinase 2 prevents mesenchymal transformation by maintaining Foxc2 in the cytoplasm (2014) (27)
Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity (1994) (27)
Breast Regression Protein-39/Chitinase 3-Like 1 Promotes Renal Fibrosis after Kidney Injury via Activation of Myofibroblasts. (2017) (26)
Phosphatidylinositol-3 kinase and growth regulation. (1992) (26)
ZIP codes for delivering SH2 domains (2004) (26)
Using peptide libraries to identify optimal cleavage motifs for proteolytic enzymes. (2004) (26)
The (Na,K)-ATPase of Friend erythroleukemia cells is phosphorylated near the ATP hydrolysis by an endogenous membrane-bound kinase. (1984) (26)
Substrate specificity and inhibitors of LRRK 2 , a protein kinase mutated in Parkinson ’ s disease (2009) (26)
SIRT6 Puts Cancer Metabolism in the Driver’s Seat (2012) (25)
A slow interconversion between active and inactive states of the (Na-K)ATPase. (1976) (25)
Sequence specificity of C-terminal Src kinase (CSK)--a comparison with Src-related kinases c-Fgr and Lyn. (1997) (25)
HGF promotes adhesion of ATP-depleted renal tubular epithelial cells in a MAPK-dependent manner. (2001) (24)
The role of phosphoinositide 3-kinase in human disease. (2004) (24)
Age-induced methylmalonic acid accumulation promotes tumor progression (2020) (24)
Quantification and localization of M2 macrophages in human kidneys with acute tubular injury (2014) (24)
A covalent small molecule inhibitor of glutamate-oxaloacetate transaminase 1 impairs pancreatic cancer growth. (2019) (24)
Phosphorylation-dependent substrate selectivity of protein kinase B (AKT1) (2020) (24)
Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. (2018) (23)
Effect of water diuresis and water restriction on expression of HSPs-27, -60 and -70 in rat kidney. (1996) (23)
Ion transport systems sequenced (1986) (23)
Epithelial morphogenesis of MDCK cells in three-dimensional collagen culture is modulated by interleukin-8. (2013) (23)
Inositol 1,4,5-trisphosphate stimulates phosphorylation of a 62,000-dalton protein in monkey fibroblast and bovine brain cell lysates. (1984) (23)
Computational prediction of protein-protein interactions. (2015) (23)
Signal transduction : principles, pathways, and processes (2014) (23)
NRF2 Rewires Cellular Metabolism to Support the Antioxidant Response (2016) (23)
IκB Kinase α Phosphorylation of TRAF4 Downregulates Innate Immune Signaling (2012) (23)
Phase II, 2‐stage, 2‐arm, PIK3CA mutation stratified trial of MK‐2206 in recurrent endometrial cancer (2019) (23)
Phase II, two-stage, two-arm, PIK3CA mutation stratified trial of MK-2206 in recurrent endometrial cancer (EC). (2013) (22)
Expression of an ouabain resistance gene in transfected cells. Ouabain treatment induces a K+-transport system. (1985) (22)
Positive and negative roles of p85α and p85β regulatory subunits of phosphoinositide 3-kinase in insulin signaling. (2017) (22)
Abstract CT324: Phase I of oral BKM120 or BYL719 and olaparib for high-grade serous ovarian cancer or triple-negative breast cancer: Final results of the BKM120 plus olaparib cohort (2015) (22)
Signal transduction: From the atomic age to the post-genomic era. (2014) (22)
Identification of small molecule inhibitors of pyruvate kinase M 2 (2010) (22)
Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine (2018) (22)
Identification of efficient pentapeptide substrates for the tyrosine kinase pp60c-src. (1995) (21)
The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple Negative Breast Cancer. (2020) (21)
Brg1 determines urothelial cell fate during ureter development. (2013) (21)
Quantitative Phosphoproteomic Analysis Identifies the Adaptor Protein Grb 10 as an mTORC 1 Substrate that Negatively Regulates Insulin Signaling (2011) (21)
A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase (2016) (21)
Human primary immunodeficiency caused by expression of a kinase-dead p110δ mutant. (2019) (21)
PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism (2018) (21)
Phenformin Enhances the Efficacy of ERK Inhibition in NF1-Mutant Melanoma. (2017) (21)
Met -/- kidneys express epithelial cells that chemotax and form tubules in response to EGF receptor ligands. (1997) (21)
Protein kinase C of human erythrocytes phosphorylates bands 4.1 and 4.9. (1986) (20)
Tyrosine Kinase BMX Phosphorylates Phosphotyrosine-Primed Motif Mediating the Activation of Multiple Receptor Tyrosine Kinases (2013) (20)
Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. (2018) (20)
Kinetic analysis of guanosine 5'-O-(3-thiotriphosphate) effects on phosphatidylinositol turnover in NRK cell homogenates. (1987) (20)
Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors. (2020) (20)
The commonly used β-actin-GFP transgenic mouse strain develops a distinct type of glomerulosclerosis (2007) (20)
Binding Specificity and Mutational Analysis of the Phosphotyrosine Binding Domain of the Brain-specific Adaptor Protein ShcC (*) (1996) (20)
Phosphatidylinositol 3-Kinase Confers Resistance to Encephalomyocarditis and Herpes Simplex Virus-Induced Cell Death Through the Activation of Distinct Downstream Effectors1 (2001) (20)
Identification and Characterization of a Phosphoinositide Phosphate Kinase Homolog* (2004) (20)
Characterization of monovalent ion transport systems in an insect cell line (Manduca sexta embryonic cell line che) (1984) (19)
Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy (2019) (19)
Development of an intracellularly acting inhibitory peptide selective for PKN. (2010) (19)
Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry (2021) (19)
Dietary Fat and Sugar in Promoting Cancer Development and Progression (2019) (19)
Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer (2021) (18)
Ancient Sensor for Ancient Drug (2012) (18)
FoxO 3 coordinates metabolic pathways to maintain redox balance in neural stem cells (2013) (18)
Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks. (2019) (18)
PIK3CA C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3Kα Inhibitors (2017) (18)
Genomic characteristics of trastuzumab-resistant Her2-positive metastatic breast cancer (2017) (17)
Specificity in protein-tyrosine kinase signaling. (1997) (17)
Met activation is required for early cytoprotection after ischemic kidney injury. (2014) (17)
Synthesis and activity of C11-modified wortmannin probes for PI3 kinase. (2005) (17)
Hepatocyte Growth Factor (Hgf) Stimulates Low Density Lipoprotein Receptor-related Protein (Lrp) 5/6 Phosphorylation and Promotes Canonical Wnt Signaling* (2014) (17)
Translocating Tubby (2001) (16)
Modulation of c-fos and egr-1 expression in the isolated perfused kidney by agents that alter tubular work. (1997) (16)
Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells. (1998) (16)
Fate of a bioactive fluorescent wortmannin derivative in cells. (2008) (16)
Proteomic screening method for phosphopeptide motif binding proteins using peptide libraries. (2011) (16)
Ouabain-resistant transfectants of the murine ouabain resistance gene contain mutations in the alpha-subunit of the Na,K-ATPase. (1992) (16)
The antiproliferative cytostatic effects of a self-activating viridin prodrug (2009) (16)
Erratum: Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion (2016) (16)
Ouabain-resistant transfectants of the murine ouabain resistance gene contain mutations in the alpha-subunit of the Na,K-ATPase. (1992) (16)
Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer (2020) (16)
Using tandem mass spectrometry in targeted mode to identify activators of class IA PI3K in cancer. (2011) (15)
Cancer, metabolism, fructose, artificial sweeteners, and going cold turkey on sugar (2013) (15)
PIK3CA and MAP3K1 alterations imply luminal A status and are associated with clinical benefit from pan-PI3K inhibitor buparlisib and letrozole in ER+ metastatic breast cancer (2019) (15)
A Glycolysis Outsider Steps into the Cancer Spotlight. (2018) (15)
The era of cancer discovery. (2011) (15)
GSK3beta plays dirty in acute kidney injury. (2010) (14)
Par 3 functions in the biogenesis of the primary cilium in polarized epithelial cells (14)
Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase (2019) (14)
Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. (2019) (14)
The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation (2018) (14)
Hepatocyte growth factor induces MAPK-dependent formin IV translocation in renal epithelial cells. (2000) (14)
Conformational Changes of Na,K-ATPase Necessary for Transport (1983) (14)
High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells. (2020) (14)
In-gel stable isotope labeling for relative quantification using mass spectrometry (2006) (14)
VEGF Attenuates Hyperoxic Injury through Decreased Apoptosis in Explanted Rat Embryonic Lung (2008) (14)
Biochemistry. PI3K charges ahead. (2007) (13)
Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms. (2005) (13)
Type 2 phosphatidylinositol 4-kinase is recruited to CD4 in response to CD4 cross-linking. (1995) (13)
The Terminator mouse is a diphtheria toxin receptor knockin mouse strain for rapid and efficient enrichment of desired cell lineages (2013) (13)
Hepatocyte Growth Factor stimulated cell scattering requires ERK and Cdc42-dependent tight junction disassembly. (2010) (12)
Anastasiou Contributes to Cellular Antioxidant Responses Inhibition of Pyruvate Kinase M 2 by Reactive Oxygen Species (2012) (12)
Slow self-activation enhances the potency of viridin prodrugs. (2008) (12)
Discovery and Structure-Activity Relationship Study of (Z)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. (2020) (12)
Characterization of a Ca2+-stimulated Mg2+-dependent adenosine triphosphatase in Friend murine erythroleukemia cell plasma membranes. (1984) (12)
Expression of c-ret promotes morphogenesis and cell survival in mIMCD-3 cells. (1999) (11)
Phosphoinositide kinases. (1996) (11)
Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis (Nature Chemical Biology (2012) 8 (839-847)) (2012) (11)
Treating cancer with phosphatidylinositol-3-kinase inhibitors: increasing efficacy and overcoming resistance (2019) (11)
IL‐1β Drives Production of FGF‐23 at the Onset of Chronic Kidney Disease in Mice (2020) (11)
Development of a Targeted Urine Proteome Assay for kidney diseases (2016) (11)
ML285 affects reactive oxygen species’ inhibition of pyruvate kinase M2 (2013) (11)
Peptide libraries: at the crossroads of proteomics and bioinformatics. (2004) (11)
LOCATION OF BINDING SITES ON THE (Na.K)‐ATPase FOR FLUORESCEIN‐5′‐ISOTHIOCYANATE AND OUABAIN * (1982) (11)
Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy (2022) (10)
Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis. (2020) (10)
Phosphatidylinositol 3 kinase is activated by insulin (1990) (10)
PI 3-Kinase and Receptor-Linked Signal Transduction (1996) (10)
Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. (2020) (10)
Structural changes in (Na+ + K+)-ATPase accompanying detergent inactivation. (1980) (10)
Identification and Characterization of a High-Affinity Interaction between v-Crk and Tyrosine-Phosphorylated Paxillin in CT 10-Transformed Fibroblasts (2003) (10)
The Phosphoinositide 3-Kinase Regulatory Subunit p85 Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling (2010) (10)
PI3K enters beta-testing. (2008) (10)
Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification (2020) (9)
At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy (2022) (9)
Evolution of Ime 2 Phosphorylation Sites on Cdk 1 Substrates Provides a Mechanism to Limit the Effects of the Phosphatase Cdc 14 in Meiosis (9)
Developing dietary interventions as therapy for cancer. (2022) (9)
An integrated vector system for cellular studies of phage display-derived peptides. (2002) (9)
Suppression of Nkx3.2 by phosphatidylinositol-3-kinase signaling regulates cartilage development by modulating chondrocyte hypertrophy. (2015) (8)
Erratum: ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect (Nature Cell Biology (2012) 14 (1295-1304)) (2013) (8)
Heparin binding VEGF isoforms attenuate hyperoxic embryonic lung growth retardation via a FLK1-neuropilin-1-PKC dependent pathway (2014) (8)
Polycystin 2 is increased in disease to protect against stress-induced cell death (2020) (8)
Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models (2022) (8)
Results of an abbreviated phase II study of AKT inhibitor MK-2206 in the treatment of recurrent platinum-resistant high grade serous ovarian, fallopian tube, or primary peritoneal carcinoma (NCT 01283035) (2020) (8)
Development of a CDK10/CycM in vitro Kinase Screening Assay and Identification of First Small-Molecule Inhibitors (2020) (8)
Quantification of Urinary Protein Biomarkers of Autosomal Dominant Polycystic Kidney Disease by Parallel Reaction Monitoring (2018) (8)
Deletion of the phosphoinositide 3-kinase p 110 { gamma } gene attenuates murine (2007) (8)
Ouabain-resistant OR6 cells express the murine alpha 1-subunit of the Na,K-ATPase with a T797-I797 substitution. (1994) (8)
Ionic regulation of MEL cell commitment (1983) (7)
Mapping Post-Translational Modifications of de Novo Purine Biosynthetic Enzymes: Implications for Pathway Regulation. (2019) (7)
Regulation of CD4-p56lck-associated phosphatidylinositol 3-kinase (PI 3-kinase) and phosphatidylinositol 4-kinase (PI 4-kinase). (1993) (7)
PI3K drives the de novo synthesis of coenzyme A from vitamin B5 (2022) (7)
Oncogenes and phosphatidylinositol turnover. (1986) (7)
Cellular Control Mechanisms that Regulate Pyruvate Kinase M 2 Activity and Promote Cancer Growth (2012) (7)
Erratum: NRF2 regulates serine biosynthesis in non–small cell lung cancer (2016) (7)
A wortmannin-cetuximab as a double drug. (2009) (7)
Oncogenes and Phosphatidylinositol Turnover a (1986) (7)
Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway (2013) (7)
Ion fluxes and differentiation in transformed cell lines. (1985) (6)
Use of a Targeted Urine Proteome Assay (TUPA) to identify protein biomarkers of delayed recovery after kidney transplant (2017) (6)
Mouse phosphoinositide 3-kinase p110alpha gene: cloning, structural organization, and localization to chromosome 3 band B. (1999) (6)
A global atlas of substrate specificities for the human serine/threonine kinome (2022) (6)
Targeting Metabolic Scavenging in Pancreatic Cancer (2013) (6)
Erratum: Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers (Proceedings of the National Academy of Sciences of the United States of America (2016) 113 (1778-1783) DOI:10.1073/pnas.1521548113) (2016) (6)
Comparison with the Muscarinic Agonist Carbachol (1990) (6)
The Phosphoinositide 3-Kinase Regulatory Subunit p 85 Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling (2011) (6)
A flattened face for membranes (1998) (6)
Altered propionate metabolism contributes to tumor progression and aggressiveness (2022) (6)
Sugar free, cancer free? (2012) (6)
Isolated MTAL cells produce an inhibitor of ouabain-sensitive oxygen consumption. (1991) (6)
Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma (2021) (5)
Phosphatidylinositol 4-Kinases (1998) (5)
Cell cycle dependence of inositol phosphate levels in neuroblastoma cells. (1988) (5)
Delta endotoxin inhibits Rb+ uptake, lowers cytoplasmic pH and inhibits a K+-ATPase inManduca sexta CHE cells (2005) (5)
CV-1 cell recipients of the mouse ouabain resistance gene express a ouabain-insensitive Na,K-ATPase after growth in cardioactive steroids. (1988) (5)
Publisher Correction: Suppression of insulin feedback enhances the efficacy of PI3K inhibitors (2018) (5)
Growth Factor and Oncogene Influences on Cell Growth Regulation (1988) (5)
The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4 (2021) (4)
Growth Factors Bind Receptor Tyrosine Kinases to Stimulate Cell Survival, Cell Division, Cell Growth, and Cytoskeletal Rearrangement (2003) (4)
Abstract CT008: Phase I study of the alpha specific PI3-Kinase inhibitor BYL719 and the poly (ADP-Ribose) polymerase (PARP) inhibitor olaparib in recurrent ovarian and breast cancer: Analysis of the dose escalation and ovarian cancer expansion cohort (2017) (4)
Arginase-1 Is Required for Macrophage-Mediated Renal Tubule Regeneration. (2022) (4)
A phase II study of MK-2206, an AKT inhibitor, in uterine serous carcinoma (2022) (4)
Somatic Mutations of PIK 3 R 1 Promote Gliomagenesis (2012) (4)
A murine genomic DNA fragment amplifies ouabain-induced Na,K-ATPase alpha/beta-subunit mRNA up-regulation and confers ouabain resistance. (1993) (4)
Vulnerabilities of PTEN – TP 53-Defi cient Prostate Cancers to Compound PARP – PI 3 K Inhibition (2019) (4)
A murine genomic DNA fragment amplifies ouabain-induced Na,K-ATPase alpha/beta-subunit mRNA up-regulation and confers ouabain resistance. (1993) (4)
Principles of Cell Signaling (2013) (3)
Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer (2022) (3)
[12] - Phosphatidylinositol 3-Kinase (1993) (3)
AMPK mediates regulation of glomerular volume and podocyte survival (2021) (3)
Tubular Cell Dropout in Preimplantation Deceased Donor Biopsies as a Predictor of Delayed Graft Function (2021) (3)
Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb (2022) (3)
SARS-CoV-2 hijacks p38β/MAPK11 to promote virus replication (2021) (3)
Workshops in Fluid and Electrolyte Disorders (1995) (3)
PI3-Kinases: Role in Signal Transduction (2000) (3)
Abstract 33: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate (2010) (3)
SIRT3 Is a Novel Metabolic Driver of and Therapeutic Target for Chemotherapy Resistant Dlbcls (2017) (3)
The PI3K regulatory subunit p85α can exert tumor suppressor properties through negative regulation of growth factor signalling (2011) (3)
ATP Produces Two Cai Responses in Rat Parotid Cells (1990) (3)
Phosphoinositide kinase activity and transformation. (1986) (3)
Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain (2020) (3)
Lipid research picks up speed on the slopes of Taos. (2002) (3)
PIK3IP1 Inhibition of PI3K in G1 Arrest Induced By CDK4 Inhibition Reprograms MCL for Ibrutinib Therapy (2016) (3)
Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry (2022) (3)
Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition (2022) (3)
Membrane Lipids Speak to Histones. (2017) (3)
Double PIK3CA mutations in cis enhance PI3Kα oncogene activation and sensitivity to PI3Kα inhibitors in breast cancer. (2019) (3)
Using Imaging Mass Cytometry to Define Cell Identities and Interactions in Human Tissues (2021) (3)
Abstract CT232: SU2C Phase Ib study of the PI3K-alpha inhibitor BYL719 (alpelisib) with letrozole in ER+/HER2-metastatic breast cancer (2015) (3)
Correction for Taniguchi et al., Phosphoinositide 3-kinase regulatory subunit p85α suppresses insulin action via positive regulation of PTEN (2016) (3)
Phase 1b Clinical Trial with Alpelisib plus Olaparib for Patients with Advanced Triple-Negative Breast Cancer. (2022) (3)
ATM and lymphoid malignancies; use of oriented peptide libraries to identify novel substrates of ATM critical in downstream signaling pathways. (1999) (3)
Differential Dependence On Aerobic Glycolysis In Normal and Malignant Hematopoietic Stem and Progenitor Cells To Sustain Daughter Cell Production (2013) (3)
The Active Site Structure of Na,K-ATPase: Location of a Specific Fluorescein Isothiocyanate-Reactive Site (1983) (3)
-Dependent Activation of the mTORC2 Kinase Complex (2015) (3)
Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85a subunit (signal transductionyGTPase-activating proteinyx-ray crystallographyyCdc42Hs) (1996) (2)
PTEN loss as a context-dependent determinant of patient outcomes in obese and non-obese endometrioid endometrial cancer patients. (2013) (2)
Synthesis and Activity of C 11-Modified Wortmannin Probes for PI 3 Kinase (2)
Abstract 5497: Cabozantinib eradicatesde novocastrate-resistant PTEN/p53 deficient murine prostate cancer via activation of neutrophil-mediated anti-tumor innate immunity (2015) (2)
The plasma membrane (Mg2+)-dependent adenosine triphosphatase from the human erythrocyte is not an ion pump (2005) (2)
GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase (2020) (2)
Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain Metastasis (2020) (2)
Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data. (2021) (2)
Targeting the PI5P4K lipid kinase family in cancer using novel covalent inhibitors (2019) (2)
Author Correction: Fatty acid synthesis is required for breast cancer brain metastasis. (2021) (2)
Purification and characterization of human erythrocyte phosphatidylinositol 4-kinase (2005) (2)
Abstract KN01: Keynote Lecture: PI 3-kinase links obesity, insulin resistance, and cancer (2018) (2)
Abstract GS6-06: A neoadjuvant trial with letrozole identifiesPRR11in the 17q23 amplicon as a mechanism of resistance to endocrine therapy in ER-positive breast cancer (2020) (2)
Abstract NG03: Chromosomal instability promotes metastasis through a cytosolic DNA response (2018) (2)
Erratum to Chitinase 3-like 1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2, [Cell Reports 4, 2013, 830-841] (2015) (2)
Extracellular ATP Gates a Ca2+‐Permeable Nonselective Cation Channel in Rat Parotid Acinar Cells (1990) (2)
Sizing up a growing field (2004) (2)
Abstract P3-07-41: Genomic alterations indicative of a luminal A subtype associate with clinical benefit to buparlisib and letrozole in endocrine-resistant ER+/HER2– metastatic breast cancer (2016) (2)
CHARACTERIZATION OF A PLASMA MEMBRANE KINASE WHICH SPECIFICALLY PHOSPHORYLATES THE (NA,K)PUMP (1983) (1)
Abstract A33: Utilizing insulin the treatment of prostate cancer with BKM120 abrogates the therapeutic effect of PI3K pathway inhibition (2015) (1)
Chapter 11 B Lymphocyte Differentiation: Role of Phosphoinositides, C Kinase, and Na+-H+ Exchange (1986) (1)
Abstract CT338: Combination of a PI3K- and a PARP-inhibitor to treat high-grade serous ovarian or triple-negative breast cancer (2014) (1)
Comparison of the Na+ Pump and the Ouabain-Resistant K+ Transport System with Other Metal Ion Transport ATPases (1986) (1)
Abstract TS2-1: The complexity of targeting PI3K for cancer therapy (2019) (1)
Seeking out the sweet spot in cancer therapeutics: an interview with Lewis Cantley (2016) (1)
Class IA phosphatidylinositol 3-kinases are indispensable for osteoclast function by regulating cytoskeletal organization and cell death (2009) (1)
1954P A pan-cancer analysis of double PIK3CA mutations (2020) (1)
Development of Inhibitors of PIP4K2 As a Treatment for Patients with Hematologic Malignancies (2018) (1)
The lipid products of phosphatidylinositol 3-kinase mediate chemotaxis via protein kinase C (1995) (1)
Phosphatidylinositol 4-kinases. Assays and product analysis. (1998) (1)
Non-conserved metabolic regulation by LKB1 distinguishes human and mouse lung adenocarcinoma (2021) (1)
Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication (2022) (1)
Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression (2022) (1)
Growth and survival signaling by lipid kinases (2008) (1)
PIK 3 CA C 2 domain deletions hyperactivate phosphoinositide 3-kinase ( PI 3 K ) , generate oncogene dependence and are exquisitely sensitive to PI 3 Kα inhibitors (2017) (1)
Phosphoinositide 3-Kinase regulates glycolysis through mobilization of Aldolase A from the actin cytoskeleton (2014) (1)
Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma. (2022) (1)
Homeostasis Enzyme Bifunctionality in Glucose Switching and Its Circumvention by A Fundamental Trade-off in Covalent Computational Biology: (2014) (1)
D2-07: Mechanisms of activating PI3K signaling in lung cancers that become resistant EGFR tyrosine kinase inhibitors (2007) (1)
The role of lipid-derived second messengers in cell growth and transformation. (1987) (1)
A topical report on the design principles of metabolism (2018) (1)
PI3K-Akt-mTOR Signaling in Cancer and Cancer Therapeutics (2016) (1)
Pancreatic cancers depend on a non-canonical glutamine metabolism pathway (2014) (1)
Role of Na+ andCa2+ Fluxes in Terminal Differentiation of Murine Erythroleukemia Cells (1983) (1)
Marine source ω-3 fatty acid, docosahexaenoic acid (DHA), inhibits human colorectal cancer growth through multiple mechanisms depending on the mutational status of p53 protein (2005) (1)
Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase (Proceedings of the National Academy of Sciences of the United States of America (2009) 103, 45, (16882-16887) 10.1073/pnas. 0607984103) (2009) (1)
Histone Methylation-Adenosylmethionine and S Influence of Threonine Metabolism on (1)
Phosphatidylinositol kinases and cell transformation. (1986) (1)
Getting Knit-PI3Ky: PIK3CA Mutation Status to Direct Multimodality Therapy? (2009) (1)
Erratum: Acetate fuels the cancer engine (Cell (2014) 159 (1492-1494)) (2015) (1)
Yonghao Yu Substrate That Negatively Regulates Insulin Signaling Phosphoproteomic Analysis Identifies Grb 10 as an mTORC 1 (2011) (1)
708: A Phase Ib study of BKM120 combined with abiraterone acetate for castrate-resistant, metastatic prostate cancer (2014) (1)
Abstract IA01: Targeting phosphoinositide 3-kinase for cancer therapy (2015) (1)
Abstract B45: Pancreatic cancers depend on a non-canonical glutamine metabolism pathway (2015) (1)
PD-142 ErbB-3 mediates PI3K activity in gefitinib-sensitive non-smallcell lung cancer cell lines (2005) (1)
Erratum: BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of pi3k (Cell Metabolism (2014:20:73-84)) (2014) (1)
Abstract 2808: Characterization of KRAS rearrangements in metastatic prostate cancer (2011) (1)
PI 3-kinase and disease (2014) (1)
Faculty Opinions recommendation of Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. (2011) (1)
Oncogenic in Mammary Epithelial Cells Mutations Are PIK 3 CA Associated − Breast Cancer (2005) (1)
Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP+-Dependent Malic Enzyme 1 (2022) (1)
IgA vasculitis complicated by acute kidney failure with thrombotic microangiopathy: successful use of eculizumab (2021) (1)
Erratum: Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKCλ/ζ (Cell Metabolism (2006) 3 (343-353)) (2016) (1)
The lipid products of phosphatidylinositol 3-kinase mediate chemotaxis via protein kinase C (1995) (1)
Expression of c-ret promotes morphogenesis and cell survival in mIMCD-3 cells. (1999) (1)
Characterization of Temporospatial Distribution of Renal Tubular Casts by Nephron Tracking after Ischemia Reperfusion Injury. (2022) (1)
Abstract LB-255: A mass spectrometry platform to quantitatively profile cancer cell metabolism from cells, tumors, and fixed tissue (2011) (1)
EXTH-36. PI3K INHIBITION IN CONJUNCTION WITH THE KETOGENIC DIET REDUCES GROWTH AND NEUROINFLAMMATION IN PEDIATRIC HIGH-GRADE GLIOMA (2019) (1)
The PI3K Pathway in Colorectal Cancers (2013) (1)
Author Correction: A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer (2020) (1)
Ras Activity Regulation by Monoubiquitination (2013) (0)
Figure 3, [A) SDS-PAGE run under non-reducing...]. (2013) (0)
Pr R moprevention Meets Glucose Control (2010) (0)
P11.63 PI3K inhibition in conjunction with the ketogenic diet reduces growth and neuroinflammation in pediatric high-grade glioma (2019) (0)
Abstract 3917: DoublePIK3CAmutations incisenhance oncogene activation and sensitivity to PI3K alpha inhibitors in breast cancer (2019) (0)
1234 Vitamin C as a potential treatment for melanoma (2018) (0)
Abstract SY34-01: Biomarkers for predicting response to PI3K inhibitors (2011) (0)
Abstract 4165: Myc vs. Akt therapy in RapidCap, a GEM model for metastatic prostate cancer (2016) (0)
Correction: PIK3CA C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3Kα Inhibitors (2019) (0)
Abstract C60: Vitamin C inhibits the survival and growth of colorectal cancer cells with KRAS or BRAF mutations (2013) (0)
Abstract A51: Oncogenic Kras is required for pancreatic tumor maintenance through the regulation of anabolic glucose metabolism. (2012) (0)
Abstract PR13: Pancreatic tumor stem cells resistant to inhibition of oncogenic signaling are dependent on mitochondrial function (2015) (0)
Reply to A Drewnowski et al, O Devinsky, D A Booth and E L Gibson, and D J Millward. (2022) (0)
27A Targeting the PI3K/mTOR pathway in genetically engineered mouse models of advanced prostate cancer (2010) (0)
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. (2022) (0)
From meetings (1988) (0)
14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (1999) (0)
Leukemogenic Tyrosine Kinases Inhibit PKM2 to Promote the Warburg Effect and Tumor Growth (2010) (0)
The role of ion fluxes in hematopoietic cell differentiation. (1985) (0)
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. (2022) (0)
Maintenance of Pluripotent Stem Cells is Influenced by Ser/Thr Metabolism (2014) (0)
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. (2022) (0)
Modulation de la phosphoinositide phosphate kinase de type ii$g(b) (2003) (0)
New and revised textbooks (2004) (0)
Methodes et reactifs permettant de reguler l'expression genique (2000) (0)
Abstract OT1-4-02: Phase I study of the combination of BKM120 and olaparib for the treatment of high grade serous ovarian cancer (HGSC) and triple negative breast cancer (TNBC) (2013) (0)
1 3 D bioengineered neural tissue generated from patient-derived iPSCs develops time-1 dependent phenotypes and transcriptional features of Alzheimer ’ s disease 2 3 (2022) (0)
AMP-Activated Protein Kinase and Cancer Cell Metabolism (2011) (0)
Role of Phosphatidylinositol 3-Kinase in Growth Factor and Oncogene Signaling (1993) (0)
PI 3—kinase and cancer metabolism (2012) (0)
Figure 1, Previously reported PKM2 activator ML probes (2013) (0)
Pyruvate kinase M2 deficiency promotes a brown fat-like program in white adipocytes (2012) (0)
Differential Immediate Early Gene Expression Induced by (2001) (0)
Figure 2, [A) Hypoxia and exogenous oxidants...]. (2013) (0)
Crystal structure of PIP4KIIBETA complex with AMPPNP (2015) (0)
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. (2022) (0)
Loss of the tumour suppressor inositol polyphosphate 4-phosphatase type II in ovarian cancer-implications for therapy (2012) (0)
Figure 4, Purified recombinant PKM2 was treated with either A) DMSO or B) 1 μM ML285 followed by H2O2 for 30 minutes, diluted 100-fold and PK activity was assayed (2013) (0)
Abstract 2951: Vitamin C is selectively toxic to cancer cells harboring KRAS or BRAF mutations by targeting GAPDH (2014) (0)
PIP 4 Ks Suppress Insulin S ignaling through a Catalytic-Independent Mechanism Graphical (2019) (0)
Abstract IA08: Reprogramming human cancer cells in CDK4/6 inhibitor therapy (2016) (0)
Activation directe de la kinase activee par l'amp reposant sur l'utilisation de la kinase lkb1, suppresseur de tumeurs (2004) (0)
Abstract PO-051: Radiation therapy enhances the presentation of phosphopeptides by MHC-I on cancer cells (2021) (0)
Mutation and functional analysis of PIK3CA and PIK3R1 in endometrial cancer (2011) (0)
P13.18 Inhibition of epidermal growth factor receptor and platelet-derived growth factor receptor-alpha exerts synergistic efficacy in glioblastoma (2021) (0)
Crystal structure of PIP4KIIBETA T201M complex with AMP (2015) (0)
Abstract IA12: Coordination of mRNA processing, translation, and metabolism by mTORC1 (2020) (0)
[Table, Probe Chemical Characterization]. (2011) (0)
PI 3-kinase and disease (2012) (0)
Pyruvate kinase inhibitors and disease treatment methods (2007) (0)
Figure 8, Critical Workflow to Lead to in vivo studies of HPykM2 activators (2011) (0)
PI 3-KINASE KNOCKOUT MICE: ROLE OF p85α IN B CELL DEVELOPMENT AND PROLIFERATION (1999) (0)
Inhibition of Phosphatidylinositol-5-Phosphate 4-Kinases (PI5P4Kα and β) Inhibits Proliferation and Radiosensitizes Triple Negative Breast Cancer Cells Harboring p53 Mutations (2015) (0)
Abstract 16: Patterns and regulation of post translational modifications in cancer (2021) (0)
Abstract 1081: Non-random genomic alterations in BRCA1-related breast cancer (2015) (0)
P13.07 Cysteine induces glioblastoma cytotoxicity through mitochondrial reductive stress (2021) (0)
160 Cancer-associated IDH1 and IDH2 mutations: therapeutic opportunities (2010) (0)
Age-induced methylmalonic acid accumulation promotes tumor progression and aggressiveness (2020) (0)
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. (2022) (0)
Crystal structure of PIP4KIIBETA N203A complex with AMP (2015) (0)
The primary pathway from PI 3 K to mTORC 1 : switching on Rheb (2016) (0)
Cancer Discovery at one year: the editors' interim analysis. (2012) (0)
Molecular Oncology: PI3K (2013) (0)
Using Departments of Pathology And (2011) (0)
Abstract 4714: Targeting p53 mutant cancers through inhibition of the phosphatidylinositol-5-phosphate 4-kinases (2015) (0)
Kidney and Electrolyte Disturbances (2000) (0)
Abstract CT418: A Phase Ib study of BKM120 combined with abiraterone acetate for castrate-resistant, metastatic prostate cancer (2014) (0)
Role of the PI 3-kinase signaling pathway in cell regulation and human disease (2010) (0)
Cell and molecular physiology. Modulation of membrane transport systems (1988) (0)
Abstract LB-188: Positive regulation of the Ras oncogene by ubiquitination (2010) (0)
PTEN PATHWAYS & TARGETS (2010) (0)
Introduction: Understanding Human AKI. (2018) (0)
Abstract MS1-1: Targeting PI3K (2012) (0)
The PI3K-LKB1 Pathway (2016) (0)
Abstract IA22: PI3K and cancer metabolism (2013) (0)
Abstract 34: Oncogenic tyrosine kinases phosphorylate and inhibit PKM2 to provide a metabolic advantage to tumor growth (2010) (0)
Stefan Wuchty , of Knowledge The Increasing Dominance of Teams in Production (2009) (0)
A 'fast'er way to treat breast cancer. (2020) (0)
Abstract 2636: Myc vs. Akt therapy in RapidCap, a GEM model for metastatic prostate cancer (2015) (0)
Author Correction: Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer (2022) (0)
Phosphatidylinositol 3-kinase: A Novel Signal Transduction Pathway? (1992) (0)
Figure 6, ML285-bound crystal structure of human pyruvate kinase M2 (PDB code: 3GR4) (2013) (0)
O-009 Differential effects of gefitinib and cetuximab on EGFR mutant non-small cell lung cancers (NSCLC) cell lines (2005) (0)
Blocking ActRIIB signaling and restoring appetite reverses cachexia and improves survival in mice with lung cancer (2021) (0)
Evolution of host protease interactions among SARS-CoV-2 variants of concern and related coronaviruses (2022) (0)
Cell Metabolism Previews PI 3 K Enters Beta-Testing (0)
Minireview Blocks Apoptosis (1997) (0)
Vascular Endothelial Growth Factor (VEGF) Attenuates Hyperoxia Via Neuropilin-1 (nrp)-Protein Kinase C (pkc) Dependent Pathway In Explanted Embryonic Lung (2011) (0)
Membrane biochemistry of the ouabain-resistant potassium transport system. (1987) (0)
Abstract 1772:PIK3CAC2 domain deletions hyperactivate PI3K, generate oncogene dependence and are exquisitely sensitive to PI3Kα inhibitors (2017) (0)
AMP-Kinase mediates regulation of glomerular volume and podocyte survival (2021) (0)
Figure 2, PBS Buffer Stability of NCGC00185916/CID-44543605 (2011) (0)
EXTH-12. INHIBITION OF EPIDERMAL GROWTH FACTOR RECEPTOR AND PLATELET-DERIVED GROWTH FACTOR RECEPTOR-ALPHA EXERTS SYNERGISTIC EFFICACY IN GLIOBLASTOMA (2021) (0)
Abstract 4588: Identification of CDCP1 as a HIF-2α target gene involved in the regulation of cancer cell migration and metastasis. (2013) (0)
Abstract LB-418: Targeting the PI3K/mTOR pathway in genetically engineered mouse models of prostate cancer (2011) (0)
Abstract LB-161: Metformin increases lipolytic metabolism and PEDF expression in prostate cancer cells (2012) (0)
DDRE-07. FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS (2021) (0)
Abstract 4979: Cabozantinib eradicates advanced murine prostate cancer by activating neutrophil-mediated anti-tumor innate immunity (2016) (0)
A Decade of Cancer Discovery. (2021) (0)
Abstract P3-03-01: DoublePIK3CAmutations incisdrive oncogene addiction and enhance sensitivity to PI3K alpha inhibitors in breast cancer (2020) (0)
Abstract 12839: Cardiac-Specific Deletion of RhoA Results in the Development of Cardiac Hypertrophy via Effects on the Erk/MAPK and PI3K/Akt pathways (2010) (0)
CHAPTER 11 – Principles of Cell Signaling (2008) (0)
SAT-LB057 High-Fructose Corn Syrup Enhances Intestinal Tumor Growth in Mice (2019) (0)
Faculty of 1000 evaluation for Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. (2011) (0)
Methionine-Labeled Proteins in CHO / IR Cells (0)
Figure 8, [A) Intracellular ROS levels measured...]. (2013) (0)
Program at a Glance (2022) (0)
cell morphogenesis The chemokine KC regulates HGF-stimulated epithelial (2016) (0)
Targeting PI3K Remains Complex in Cancer Therapy (2018) (0)
Cancer evention esearch pective rspective on Memmott et al . , p . 1066 Pr R moprevention Meets Glucose Control (2010) (0)
105 INVITED The role of PI3K in cancer (2007) (0)
Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production (2021) (0)
compound PARP / PI 3 K inhibition Vulnerabilities of PTEN-p 53-deficient prostate cancers to (2014) (0)
Abstract NG05: Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53 null tumors (2014) (0)
Contributors to Volume 18 (1993) (0)
Abstract 162: Identification of novel targets of Serine/arginine-rich protein-specific kinase 2 (2022) (0)
Crystal structure of PIP4KIIBETA I368A complex with AMP (2015) (0)
Therapeutic Effects of Metformin The Kinase LKB 1 Mediates Glucose Homeostasis in Liver and (2012) (0)
Methods of treating resistant cancer therapeutic agents ERBB (2008) (0)
Faculty Opinions recommendation of Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene. (2011) (0)
Abstract 981: A genetic-metabolic axis of metastatic liver organotropism (2022) (0)
Abstract IA14: Autophagy, metabolism, and pancreatic cancer. (2012) (0)
Abstract IA08: PI3K- and PARP-inhibitors for the treatment of women cancers. (2016) (0)
Abstract SY12-01: PI 3-kinase and cancer metabolism (2016) (0)
The Phosphatidylinositol 3‐Kinase Pathway in Human Malignancies (2015) (0)
Lessons in signal transduction from a DNA tumor virus (1995) (0)
Integrated Systems and Technologies Using Tandem Mass Spectrometry in Targeted Mode to Identify Activators of Class IA PI 3 K in Cancer (2011) (0)
Vascular endothelial growth factor (VEGF) isoform attenuates hyperoxic injury of embryonic lung via a Flk1–neuropilin (Nrp)-1–protein kinase C (PKC) dependent pathway (2013) (0)
Characterization of PXK as a Protein Involved in Epidermal Growth Factor Receptor Trafﬁcking (cid:1) (2010) (0)
14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 1) (1999) (0)
Radiation-Induced Activation of Innate Immune Pathways from Errors in Mitosis (2017) (0)
Abstract LB-365: Effective use of PI3K/MTOR and MEK inhibitors prior to hormone ablative therapy in PTEN-loss driven murine prostate cancer (2012) (0)
(acidification of coated vesicles/endocytosis/receptors) (2016) (0)
Abstract 3175: Methylmalonic acid in TME signaling (2022) (0)
Abstract 2062: Evaluating the effect of tumor necrosis on glycolytic flux and cell survival in glioblastoma (2019) (0)
Abstract NG16: DoublePIK3CAmutations incisincrease oncogenicity and sensitivity to PI3Kα inhibitors (2020) (0)
Targeting chromosomal instability and downstream cytosolic dna signaling for cancer treatment (2018) (0)
Obesity promotes breast epithelium DNA damage in BRCA mutation carriers (2022) (0)
A Mass Spectrometry Platform to Quantitatively Profile Cancer Cell Metabolism from Cell Lines to Tissues. (2010) (0)
Abstract B24: Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation (2020) (0)
Phosphatidylinositol pathways in growth and transformation (1990) (0)
Figure 4, PBS Buffer Stability of NCGC00185939/CID-4547230 (2011) (0)
Figure 7, [A) [1-14C]glucose flux through PPP...]. (2013) (0)
Table 4, SAR of selected thieno[3,2-b]pyrrole[3,2-d]pyridazinones (2011) (0)
Targeting insulin feedback to enhance alpelisib (TIFA): A phase II randomized trial in metastatic, PIK3CA-mutant, hormone receptor–positive breast cancer. (2022) (0)
Figure 3, PBS Buffer Stability of NCGC00186527/CID-44246498 (2011) (0)
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. (2022) (0)
Editorial Note to: Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply. (2021) (0)
An Overview of Renal Development (2009) (0)
Authors' Reply: Most Arginase-1 Positive Cells Are Likely Injured S3 Proximal Tubular Cells Carrying Upregulated Phagocytotic Capacity rather than M2 Macrophages-Too Many To Be True. (2022) (0)
Crystal structure of PIP4KIIBETA F205L complex with AMP (2015) (0)
Abstract 794: Pan-cancer proteogenomic analysis reveals functional mechanisms underlying DNA repair deficiencies (2022) (0)
Abstract 159: Analysis of resistance to the combination of a PI3K- and Parp-inhibitor using a genomic sequencing approach (2016) (0)
mIMCD-3細胞での形態形成と細胞生存を促進するc-retの発現 (1999) (0)
Harlequin ichthyosis unmasked: a defect of lipid transport (2005) (0)
Abstract 956: Receptor tyrosine kinases, not KRAS, activate PI3K in KRAS mutant colorectal cancers (2011) (0)
B . canadensis Campanian Hadrosaur Biomolecular Characterization and Protein Sequences of the (2012) (0)
Methods of treating cancer resistant to ErbB doctor mites (2008) (0)
Phosphoinositide biology – messages from lipids (2000) (0)
Epinephrine inhibits PI3K alpha via the Hippo kinases (2022) (0)
Live cold to grow old? Thermogenesis to fight cancer (2022) (0)
Figure 5, [A) ML285 shows a dose-response...]. (2013) (0)
STRUCTURE OF BCR-HOMOLOGY (BH) DOMAIN (1997) (0)
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. (2022) (0)
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. (2022) (0)
Abstract IA-2: PI3‐Kinase and cancer metabolism (2009) (0)
MP46-10 UTILIZING INSULIN IN THE TREATMENT OF PROSTATE CANCER WITH BKM120 ABROGATES THE THERAPEUTIC EFFECT OF PI3K PATHWAY INHIBITION (2015) (0)
OBSERVATION AKT 1 Overexpression in Endothelial Cells Leads to the Development of Cutaneous Vascular Malformations In Vivo (2007) (0)
Phosphatidyl Inositol (4,5)P2 Marks Megakaryocyte Internal Membranes and Is Associated with Megakaryocyte Maturation and Platelet Release. (2005) (0)
DDRE-22. TARGETING SERINE SYNTHESIS IN BRAIN METASTASIS (2021) (0)
Abstract 3858: Feasibility and efficacy of a precision treatment approach for triple-negative breast cancer in mouse models (2016) (0)
FSMP-10. CYSTEINE INDUCES CYTOTOXICITY IN GLIOBLASTOMA THROUGH MITOCHONDRIAL HYDROGEN PEROXIDE PRODUCTION (2021) (0)
Activateurs de la pyruvate kinase m2 et procédé de traitement d'une maladie (2008) (0)
Crystal structure of PIP4KIIBETA complex with AMP (2015) (0)
Methods for treating cancer resistant to ErbB therapeutics (2008) (0)
Diverse Hotspot Thermal Profiling Methods Detect Phosphorylation-Dependent Changes in Protein Stability (2021) (0)
Abstract 1625: CUB domain-containing protein 1 (CDCP1) promotes metastatic phenotype in pancreatic ductal adenocarcinoma (2016) (0)
Interferon activated gene 204 (Ifi204) protects against bone loss in experimental periodontitis. (2022) (0)
The Structural Basis for Specificity in Protein-Tyrosine Kinase Signaling (1996) (0)
Increased insulin sensitivity i subunit of phosphoinositide (2016) (0)
Perianeurysmal retroperitoneal fibrosis presenting as acute kidney injury: A case report. (2021) (0)
Obesity, Insulin Resistance and Cancer: The PI3K connection (2018) (0)
Quantitative proteomics identification of potential protein biomarkers of early recovery after kidney transplant (591.5) (2014) (0)
Table 1, Final optimized 1536-well assay protocol (2011) (0)
The Role of p204 in Kidney Injury (2015) (0)
Abstract B09: Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation (2015) (0)
Downstream Effectors Through the Activation of Distinct Herpes Simplex Virus-Induced Cell Death Resistance to Encephalomyocarditis and Phosphatidylinositol 3-Kinase Confers (2001) (0)
Abstract 5712: Nutrient scarcity confers breast cancer brain metastasis sensitivity to serine synthesis pathway inhibition (2020) (0)
TAMI-38. CYSTEINE-PROMOTING COMPOUNDS INDUCE MITOCHONDRIAL TOXICITY IN GLIOBLASTOMA THROUGH ALTERED PYRUVATE AND SERINE METABOLISM (2020) (0)
Lewis C. Cantley (2009) (0)
Abstract 5121: A targeted approach to identify activators of class IA phosphoinositide-3-kinase in cancers using tandem mass spectrometry (2011) (0)
Phosphoinositide 3- Kinase and disease (2012) (0)
I (cid:1) B Kinase (cid:2) Phosphorylation of TRAF4 Downregulates Innate Immune Signaling (2012) (0)
Reply from Lewis Cantley (1986) (0)
Crystal structure of PIP4KIIBETA (2015) (0)
Abstract 2650: PI 3-Kinase inhibitors enhance the synthetic lethality of Parp inhibitors (2015) (0)
Abstract IA21: Combination treatments that include PI3K-inhibitors for the treatment of triple-negative breast cancer (2015) (0)
Physical and Functional Interactions between SH 2 and SH 3 Domains of the Src Family Protein Tyrosine Kinase p 59 fi 5 (0)
Faculty Opinions recommendation of HIF-1 mediates the Warburg effect in clear cell renal carcinoma. (2011) (0)
Abstract A21: Compound PIK3CA mutations support a mutational dose-response model for oncogene activation and response to PI3K inhibitor targeted therapy in breast cancer (2020) (0)
Table 3, SAR of selected N,N-bisarylsulfonamides (2011) (0)
Table 5, SAR of selected tetrahydroquinoline-sulfonamides (2011) (0)
INCREASE IN [Ca2+]i IN CULTURED HUMAN KERATINOCYTES BY 1,25(OH)2D3 IS CALCIUM DEPENDENT AND COINCIDES WITH AN INCREASE IN PHOSPHATIDYLINOSITOL METABOLISM. (1988) (0)
527 Impaird Kit- but not FcεRI-mediated mast cell activation in the absence of regulatory subunits encoded by the phosphoinositide 3-kinase (PI3K) p85α gene (2000) (0)
Abstract OP-03: PI 3-Kinase, AMPK, and Cancer (2012) (0)
Figure 1, Pyruvate kinase-luciferase coupled assay (2010) (0)
Abstract C112: Cabozantinib eradicates advanced murine prostate cancer by activating anti-tumor innate immunity (2015) (0)
CS-33 * DISCOVERY OF A p53-INDEPENDENT SUPPRESSOR OF SENESCENCE OF GLIOBLASTOMA MULTIFORME (2014) (0)
Na+ and Ca2+ Fluxes and Differentiation of Transformed Cells (1985) (0)
Abstract B04: NRF2 regulates serine biosynthesis in pancreatic ductal adenocarcinoma (2016) (0)
A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas (2021) (0)
The p85 (cid:2) Regulatory Subunit of Phosphoinositide 3-Kinase Potentiates c-Jun N-Terminal Kinase-Mediated Insulin Resistance (cid:1) † (2007) (0)
Abstract A078: Towards understanding noncanonical phosphatidylinositol kinases in the maintenance of prostate metabolism (2018) (0)
The C2 Domain of PKC is a new Phospho-Tyrosine Binding Domain (2005) (0)
Abstract 4265: Derivation and characterization of endometrial cancer cells resistant to phosphatidylinositol-3-kinase (PI3K) pathway inhibitors. (2013) (0)
43 Targeting PI3K: where are we? (2010) (0)
14-3-3 ZETA/PHOSPHOPEPTIDE COMPLEX (MODE 2) (1999) (0)

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