Li Ding
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Computational cancer biologist
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Li Ding's Degrees
- PhD Computer Science University of Maryland, Baltimore County
- Masters Computer Science University of Maryland, Baltimore County
- Bachelors Computer Science University of Science and Technology of China
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Why Is Li Ding Influential?
(Suggest an Edit or Addition)According to Wikipedia, Li Ding is the David English Smith Distinguished Professor of Medicine at Washington University. She is known for the development of multiple computational tools now commonly used in cancer biology research, including VarScan, HotSpot3D, and BreakDancer.
Li Ding's Published Works
Published Works
- Comprehensive molecular portraits of human breast tumors (2012) (7791)
- An integrated map of genetic variation from 1,092 human genomes (2012) (7565)
- Comprehensive molecular characterization of human colon and rectal cancer (2012) (6141)
- Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. (2010) (5816)
- Comprehensive genomic characterization defines human glioblastoma genes and core pathways (2008) (5775)
- Comprehensive molecular characterization of gastric adenocarcinoma (2014) (4496)
- Comprehensive molecular profiling of lung adenocarcinoma (2014) (4095)
- VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing. (2012) (3841)
- Integrated genomic characterization of endometrial carcinoma (2013) (3708)
- Mutational landscape and significance across 12 major cancer types (2013) (3589)
- Somatic mutations affect key pathways in lung adenocarcinoma (2008) (2640)
- Recurring mutations found by sequencing an acute myeloid leukemia genome. (2009) (2200)
- Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. (2010) (2121)
- Clonal evolution in relapsed acute myeloid leukemia revealed by whole genome sequencing (2011) (1935)
- An integrated map of structural variation in 2,504 human genomes (2015) (1800)
- Oncogenic Signaling Pathways in The Cancer Genome Atlas (2018) (1646)
- The Origin and Evolution of Mutations in Acute Myeloid Leukemia (2012) (1420)
- BreakDancer: An algorithm for high resolution mapping of genomic structural variation (2009) (1381)
- DNA sequencing of a cytogenetically normal acute myeloid leukemia genome (2008) (1365)
- Comprehensive Characterization of Cancer Driver Genes and Mutations (2018) (1360)
- Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer (2015) (1332)
- Somatic Histone H3 Alterations in Paediatric Diffuse Intrinsic Pontine Gliomas and Non-Brainstem Glioblastomas (2012) (1327)
- Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin (2014) (1192)
- Proteogenomics connects somatic mutations to signaling in breast cancer (2016) (1174)
- Genome Remodeling in a Basal-like Breast Cancer Metastasis and Xenograft (2010) (1171)
- VarScan: variant detection in massively parallel sequencing of individual and pooled samples (2009) (1155)
- Characterizing the cancer genome in lung adenocarcinoma (2007) (1122)
- Mapping copy number variation by population scale genome sequencing (2010) (1057)
- Age-related cancer mutations associated with clonal hematopoietic expansion (2014) (1053)
- Whole Genome Analysis Informs Breast Cancer Response to Aromatase Inhibition (2012) (998)
- Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers (2012) (890)
- The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma (2014) (832)
- DNMT3A mutations in acute myeloid leukemia. (2010) (782)
- Germline Mutations in Predisposition Genes in Pediatric Cancer. (2015) (769)
- Clonal architecture of secondary acute myeloid leukemia. (2012) (747)
- Pan-Cancer Network Analysis Identifies Combinations of Rare Somatic Mutations across Pathways and Protein Complexes (2014) (721)
- Activating HER2 mutations in HER2 gene amplification negative breast cancer. (2013) (658)
- Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas (2013) (655)
- Landscape of Somatic Retrotransposition in Human Cancers (2012) (638)
- Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas (2018) (600)
- MuSiC: Identifying mutational significance in cancer genomes (2012) (593)
- Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas (2017) (577)
- Multi-platform discovery of haplotype-resolved structural variation in human genomes (2017) (550)
- Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts. (2013) (543)
- SomaticSniper: identification of somatic point mutations in whole genome sequencing data (2012) (543)
- RECURRENT MUTATIONS IN THE U2AF1 SPLICING FACTOR IN MYELODYSPLASTIC SYNDROMES (2011) (530)
- Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma. (2014) (527)
- Recurrent DNMT3A Mutations in Patients with Myelodysplastic Syndromes (2011) (508)
- Pathogenic Germline Variants in 10,389 Adult Cancers (2018) (501)
- CREST maps somatic structural variation in cancer genomes with base-pair resolution (2011) (487)
- Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines. (2018) (478)
- Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients (2018) (471)
- A Novel Retinoblastoma Therapy from Genomic and Epigenetic Analyses (2011) (462)
- MSIsensor: microsatellite instability detection using paired tumor-normal sequence data (2014) (459)
- Comprehensive identification of mutational cancer driver genes across 12 tumor types (2013) (457)
- C11orf95-RELA fusions drive oncogenic NF-κB signaling in ependymoma (2014) (450)
- The Role of TP53 Mutations in the Origin and Evolution of Therapy-Related AML (2014) (442)
- DGIdb - Mining the druggable genome (2013) (418)
- Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma (2019) (403)
- SciClone: Inferring Clonal Architecture and Tracking the Spatial and Temporal Patterns of Tumor Evolution (2014) (381)
- Patterns of somatic structural variation in human cancer genomes (2020) (377)
- Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations. (2014) (377)
- Association of age at diagnosis and genetic mutations in patients with neuroblastoma. (2012) (374)
- The landscape of somatic mutations in Infant MLL rearranged acute lymphoblastic leukemias (2015) (371)
- Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities (2019) (366)
- Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA , IDH 1 , EGFR , and NF 1 Citation Verhaak (2010) (362)
- The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes (2014) (345)
- Comprehensive Characterization of Cancer Driver Genes and Mutations (2018) (340)
- Driver Fusions and Their Implications in the Development and Treatment of Human Cancers (2018) (332)
- The Pediatric Cancer Genome Project (2012) (311)
- Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma (2019) (283)
- Use of whole-genome sequencing to diagnose a cryptic fusion oncogene. (2011) (267)
- Integrated Analysis of Germline and Somatic Variants in Ovarian Cancer (2014) (259)
- Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma (2020) (244)
- The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution (2020) (234)
- Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics (2018) (234)
- Targeting oxidative stress in embryonal rhabdomyosarcoma. (2013) (228)
- Patterns and functional implications of rare germline variants across 12 cancer types (2015) (222)
- Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma. (2008) (212)
- Comprehensive molecular characterization of mitochondrial genomes in human cancers (2017) (197)
- Deregulation of DUX4 and ERG in acute lymphoblastic leukemia (2016) (197)
- Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells. (2012) (195)
- Proteogenomic Characterization of Endometrial Carcinoma (2020) (194)
- The genomic landscape of core-binding factor acute myeloid leukemias (2016) (187)
- Expanding the computational toolbox for mining cancer genomes (2014) (181)
- Optimizing cancer genome sequencing and analysis. (2015) (179)
- Proteogenomic and metabolomic characterization of human glioblastoma. (2021) (176)
- Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML. (2011) (169)
- Systematic Functional Annotation of Somatic Mutations in Cancer. (2018) (169)
- Clinical significance of CTNNB1 mutation and Wnt pathway activation in endometrioid endometrial carcinoma. (2014) (163)
- Computational approaches to identify functional genetic variants in cancer genomes (2013) (161)
- Analysis of next-generation genomic data in cancer: accomplishments and challenges. (2010) (157)
- Systematic Analysis of Splice-Site-Creating Mutations in Cancer (2018) (156)
- Challenges of sequencing human genomes (2010) (147)
- The Genomic Landscape of Childhood and Adolescent Melanoma (2014) (139)
- A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement (2011) (137)
- Congenital progressive hydronephrosis (cph) is caused by an S256L mutation in aquaporin-2 that affects its phosphorylation and apical membrane accumulation. (2006) (131)
- Visualizing tumor evolution with the fishplot package for R (2016) (119)
- Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma. (2021) (118)
- Clonal Architecture of Secondary Acute Myeloid Leukemia Defined by Single-Cell Sequencing (2014) (118)
- Protein-structure-guided discovery of functional mutations across 19 cancer types (2016) (118)
- Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif (2013) (110)
- Retrotransposition of gene transcripts leads to structural variation in mammalian genomes (2013) (110)
- Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer (2020) (109)
- The GABAA receptor α1 subunit epilepsy mutation A322D inhibits transmembrane helix formation and causes proteasomal degradation (2007) (108)
- Proteogenomic integration reveals therapeutic targets in breast cancer xenografts (2017) (108)
- U2AF1 Mutations Alter Sequence Specificity of pre-mRNA Binding and Splicing (2014) (104)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4 (2005) (98)
- TIGRA: A targeted iterative graph routing assembler for breakpoint assembly (2014) (94)
- Tumor Evolution in Two Patients with Basal-like Breast Cancer: A Retrospective Genomics Study of Multiple Metastases (2016) (92)
- An Analysis of the Sensitivity of Proteogenomic Mapping of Somatic Mutations and Novel Splicing Events in Cancer* (2015) (92)
- Erratum: Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles (Cell Reports (2017) 18(11) (2780–2794) (S2211124717302140) (10.1016/j.celrep.2017.02.033)) (2017) (88)
- PathScan: a tool for discerning mutational significance in groups of putative cancer genes (2011) (87)
- novoBreak: local assembly for breakpoint detection in cancer genomes (2016) (87)
- Somatic neurofibromatosis type 1 (NF1) inactivation characterizes NF1-associated pilocytic astrocytoma (2013) (86)
- Thymidine kinase (TK) gene-transduced human lymphocytes can be highly purified, remain fully functional, and are killed efficiently with ganciclovir. (1997) (86)
- Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma (2019) (84)
- Before and After: Comparison of Legacy and Harmonized TCGA Genomic Data Commons' Data. (2019) (83)
- Identification of disease-causing mutations in autosomal dominant retinitis pigmentosa (adRP) using next-generation DNA sequencing. (2011) (82)
- Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts (2019) (81)
- PolyScan: an automatic indel and SNP detection approach to the analysis of human resequencing data. (2007) (80)
- Genome Modeling System: A Knowledge Management Platform for Genomics (2015) (80)
- Complete characterization of the microRNAome in a patient with acute myeloid leukemia. (2010) (75)
- Clonal Architectures and Driver Mutations in Metastatic Melanomas (2014) (72)
- Advances for studying clonal evolution in cancer. (2013) (70)
- BreakFusion: targeted assembly-based identification of gene fusions in whole transcriptome paired-end sequencing data (2012) (66)
- CMDS: a population-based method for identifying recurrent DNA copy number aberrations in cancer from high-resolution data (2010) (66)
- The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development (2008) (64)
- Abstract 4869: Whole genome sequence analysis of MLL rearranged infant acute lymphoblastic leukemias reveals remarkably few somatic mutations: A Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project (2012) (61)
- Divergent viral presentation among human tumors and adjacent normal tissues (2016) (58)
- The Dynamic Genome and Transcriptome of the Human Fungal Pathogen Blastomyces and Close Relative Emmonsia (2015) (57)
- Re-sequencing Expands Our Understanding of the Phenotypic Impact of Variants at GWAS Loci (2014) (55)
- The Prognostic Role of RASSF1A Promoter Methylation in Breast Cancer: A Meta-Analysis of Published Data (2012) (53)
- Activating HER 2 Mutations in HER 2 Gene Amplifi cation Negative Breast Cancer (2012) (53)
- Fever Burden Is an Independent Predictor for Prognosis of Traumatic Brain Injury (2014) (51)
- Massively parallel sequencing approaches for characterization of structural variation. (2012) (49)
- Somatic Mutations of PIK3R1 Promote Gliomagenesis (2012) (48)
- Altered Cortical GABAA Receptor Composition, Physiology, and Endocytosis in a Mouse Model of a Human Genetic Absence Epilepsy Syndrome* (2013) (47)
- Lung cancer risk in relation to the CYP2E1 Rsa I genetic polymorphism among African-Americans and Caucasians in Los Angeles County. (1996) (47)
- GABAA Receptor α1 Subunit Mutation A322D Associated with Autosomal Dominant Juvenile Myoclonic Epilepsy Reduces the Expression and Alters the Composition of Wild Type GABAA Receptors* (2010) (45)
- Sex differences in oncogenic mutational processes (2019) (41)
- CTCF genetic alterations in endometrial carcinoma are pro-tumorigenic (2017) (40)
- Co-evolution of tumor and immune cells during progression of multiple myeloma (2021) (38)
- Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma (2020) (36)
- DNA defects, epigenetics, and gene expression in cancer-adjacent breast: a study from The Cancer Genome Atlas (2016) (35)
- Mass Spectrometry-Based Proteomics Reveals Potential Roles of NEK9 and MAP2K4 in Resistance to PI3K Inhibition in Triple-Negative Breast Cancers. (2018) (34)
- Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment (2021) (33)
- Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability (2020) (33)
- Germline determinants of the somatic mutation landscape in 2,642 cancer genomes (2017) (33)
- Cancer proteogenomics: current impact and future prospects (2022) (33)
- Association of Somatic Mutations of ADAMTS Genes With Chemotherapy Sensitivity and Survival in High-Grade Serous Ovarian Carcinoma. (2015) (31)
- Discovery of Novel Recurrent Mutations in Childhood Early T-Cell Precursor Acute Lymphoblastic Leukemia by Whole Genome Sequencing - a Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project (2011) (31)
- NFATc1 Promotes Prostate Tumorigenesis and Overcomes PTEN Loss-Induced Senescence (2015) (31)
- CharGer: clinical Characterization of Germline variants (2018) (31)
- The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis (2016) (31)
- EAnnot: a genome annotation tool using experimental evidence. (2004) (27)
- The Interleukin-10 Promoter Polymorphism rs1800872 (-592C>A), Contributes to Cancer Susceptibility: Meta-Analysis of 16 785 Cases and 19 713 Controls (2013) (27)
- BreakTrans: uncovering the genomic architecture of gene fusions (2013) (26)
- Altered intrathalamic GABAA neurotransmission in a mouse model of a human genetic absence epilepsy syndrome (2015) (25)
- Tumor-on-a-chip platform to interrogate the role of macrophages in tumor progression (2020) (24)
- Urine tumor DNA detection of minimal residual disease in muscle-invasive bladder cancer treated with curative-intent radical cystectomy: A cohort study (2021) (24)
- Ancestry-specific predisposing germline variants in cancer (2020) (23)
- Evolution and structure of clinically relevant gene fusions in multiple myeloma (2020) (23)
- Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice. (2014) (23)
- Functional analysis of BARD1 missense variants in homology-directed repair and damage sensitivity (2019) (23)
- Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples (2020) (22)
- Breast tumors educate the proteome of stromal tissue in an individualized but coordinated manner (2017) (22)
- Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples (2020) (22)
- The developmental evolution of the seizure phenotype and cortical inhibition in mouse models of juvenile myoclonic epilepsy (2015) (21)
- Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation (2016) (21)
- Effect of complement fragment 1 esterase inhibition on survival of human decay-accelerating factor pig lungs perfused with human blood. (2003) (21)
- Multi-platform discovery of haplotype-resolved structural variation in human genomes (2019) (20)
- Corrigendum: C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma (2014) (19)
- Cell-free DNA ultra-low-pass whole genome sequencing to distinguish malignant peripheral nerve sheath tumor (MPNST) from its benign precursor lesion: A cross-sectional study (2021) (18)
- Dynamic host immune response in virus-associated cancers (2019) (18)
- GenomeVIP: a cloud platform for genomic variant discovery and interpretation (2017) (17)
- Genomic Profiling of Lung Adenocarcinoma in Never-Smokers (2021) (17)
- Discovery of driver non-coding splice-site-creating mutations in cancer (2020) (17)
- Recurrent DNMT3A Mutations In Patients with Myelodysplastic Syndrome (2010) (16)
- Isotope tracing in adult zebrafish reveals alanine cycling between melanoma and liver. (2021) (16)
- Moving pan-cancer studies from basic research toward the clinic (2021) (16)
- Framework for microRNA variant annotation and prioritization using human population and disease datasets (2018) (15)
- MIRMMR: binary classification of microsatellite instability using methylation and mutations (2017) (15)
- The Role Of Early TP53 Mutations On The Evolution Of Therapy-Related AML (2013) (15)
- Integrative omics analyses broaden treatment targets in human cancer (2018) (14)
- Protein-structure-guided discovery of functional mutations across 19 cancer types (2016) (13)
- Discriminating a common somatic ASXL1 mutation (c.1934dup; p.G646Wfs*12) from artifact in myeloid malignancies using NGS (2018) (13)
- The Assessment of Bioreductive Drug Toxicity in vitro and in Experimental Tumours in vivo (1990) (13)
- The clear cell sarcoma functional genomic landscape. (2021) (13)
- LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint (2022) (13)
- Predicting Tumor Response to PD-1 Blockade. (2019) (13)
- Consortium, G.P A map of human genome variation from population-scale sequencing. Nature 467, 1061-1073 (2010) (13)
- Whole Genome Sequence Analysis of 22 MLL Rearranged Infant Acute Lymphoblastic Leukemias Reveals Remarkably Few Somatic Mutations: A Report From the St Jude Children‘s Research Hospital - Washington University Pediatric Cancer Genome Project (2011) (13)
- MSIsensor-ct: microsatellite instability detection using cfDNA sequencing data (2021) (12)
- Erratum: C11orf95-RELA fusions drive oncogenic NF-ΰ B signalling in ependymoma (Nature (2014) 506 (451-455 ) DOI:10.1038/nature13109) (2014) (12)
- Chromosome 8 gain is associated with high-grade transformation in MPNST (2020) (12)
- The effects of common structural variants on 3D chromatin structure (2020) (12)
- Functional Variant in 3'UTR of FAM13A Is Potentially Associated with Susceptibility and Survival of Lung Squamous Carcinoma. (2019) (12)
- Calcium-Sensing Receptor Genetic Polymorphisms and Risk of Developing Nephrolithiasis in a Chinese Population (2017) (11)
- Dynamic host immune response in virus-associated cancers (2019) (11)
- Association between Dyslipidemia and Nephrolithiasis Risk in a Chinese Population (2019) (10)
- Spatially interacting phosphorylation sites and mutations in cancer (2021) (9)
- MEDALT: single-cell copy number lineage tracing enabling gene discovery (2021) (9)
- Spatial drivers and pre-cancer populations collaborate with the microenvironment in untreated and chemo-resistant pancreatic cancer (2021) (9)
- Integrated transcriptomic–genomic tool Texomer profiles cancer tissues (2019) (8)
- Regulated Phosphosignaling Associated with Breast Cancer Subtypes and Druggability* (2019) (8)
- Tetrandrine inhibits proliferation of colon cancer cells by BMP9/ PTEN/ PI3K/AKT signaling (2019) (8)
- Single-cell manifold-preserving feature selection for detecting rare cell populations (2021) (8)
- Abstract 5359: Regulatory germline variants in 10,389 adult cancers (2018) (7)
- Whole-genome characterization of lung adenocarcinomas lacking the RTK/RAS/RAF pathway (2022) (7)
- The Cancer Genome Workbench: Identifying and Visualizing Complex Genetic Alterations in Tumors (2010) (7)
- Correction: Tumor Evolution in Two Patients with Basal-like Breast Cancer: A Retrospective Genomics Study of Multiple Metastases (2017) (7)
- Abstract S5-6: Activating HER2 mutations in HER2 gene amplification negative breast cancers. (2012) (7)
- Interleukin-10-819C>T polymorphism contributed to cancer risk: evidence from 29 studies. (2013) (7)
- Corrigendum: Proteogenomic integration reveals therapeutic targets in breast cancer xenografts (2017) (6)
- The Direct Semi-Quantitative Detection of 18 Pathogens and Simultaneous Screening for Nine Resistance Genes in Clinical Urine Samples by a High-Throughput Multiplex Genetic Detection System (2021) (6)
- Integrative analysis provides multi‐omics evidence for the pathogenesis of placenta percreta (2020) (6)
- Proteomic Resistance Biomarkers for PI3K Inhibitor in Triple Negative Breast Cancer Patient-Derived Xenograft Models (2020) (6)
- Expression and significance of TIMP-3, PACAP and VIP in vaginal wall tissues of patients with stress urinary incontinence (2016) (6)
- Association between KIR gene polymorphisms and type 1 diabetes mellitus (T1DM) susceptibility (2017) (6)
- MEDALT: single-cell copy number lineage tracing enabling gene discovery (2020) (6)
- ["Governor vessel daoqi method of acupuncture" combined with estazolam for insomnia: a randomized controlled trial]. (2018) (6)
- Genomic population structure of Helicobacter pylori Shanghai isolates and identification of genomic features uniquely linked with pathogenicity (2021) (4)
- Correction: Urine tumor DNA detection of minimal residual disease in muscle-invasive bladder cancer treated with curative-intent radical cystectomy: A cohort study (2021) (4)
- Ancestry-specific predisposing germline variants in cancer (2020) (4)
- Effect of BZG-4000, a novel multi-targeted kinase inhibitor with potent anticancer activity, on a hepatocellular carcinoma xenograft model (2014) (4)
- Somatic Mutations of PIK 3 R 1 Promote Gliomagenesis (2012) (4)
- BreakPoint Surveyor: a pipeline for structural variant visualization (2017) (4)
- Discovery of potent, orally active compounds of tyrosine kinase and serine/threonine-protein kinase inhibitor with anti-tumor activity in preclinical assays. (2012) (4)
- Genomic Determinants of Homologous Recombination Deficiency across Human Cancers (2021) (3)
- Pan-cancer analysis of somatic mutations across 21 neuroendocrine tumor types (2018) (3)
- RNA Splicing and Immune-Checkpoint Inhibition. (2021) (3)
- Identification of a novel heterozygous missense mutation of SEMA3E (c.1327G>A; p. Ala443Thr) in a labor induced fetus with CHARGE syndrome (2019) (3)
- Regulated Phosphosignaling Associated with Breast Cancer Subtypes and Druggability. (2019) (3)
- Nature GeNetics ADVANCE ONLINE PUBLICATION (2013) (3)
- Differences that matter in cancer genomics (2013) (3)
- Meta-analysis on the association between xeroderma pigmentosum Group A A23G polymorphism and esophageal cancer in a Chinese population (2018) (3)
- LINE-1 expression in cancer correlates with DNA damage response, copy number variation, and cell cycle progression (2020) (3)
- Abstract 926: Multi-Center Mutation Calling in Multiple Cancers: The MC3 Project (2018) (3)
- The ratio of shock index to pulse oxygen saturation predicting mortality of emergency trauma patients (2020) (3)
- PDXNet portal: patient-derived Xenograft model, data, workflow and tool discovery (2022) (3)
- Single-Cell Manifold Preserving Feature Selection (SCMER) (2020) (3)
- Metabolism and Bioactivation of Corynoline With Characterization of the Glutathione/Cysteine Conjugate and Evaluation of Its Hepatotoxicity in Mice (2018) (3)
- Erratum: A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement (European Journal of Human Genetics (2011) 19 (1074-1081) DOI: 10.1038/ejhg.2011.86) (2011) (3)
- Abstract 6580: Proteogenomic characterization of endometrial carcinoma (2020) (2)
- Analysis of somatic retrotransposition in human cancers (2012) (2)
- Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma (2021) (2)
- Complete Sequencing and Comparison of 12 Normal Karyotype M1 AML Genomes with 12 t(15;17) Positive M3-APL Genomes (2011) (2)
- Author Correction: Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts (2021) (2)
- Integrated Cytof, Scrna-Seq and Cite-Seq Analysis of Bone Marrow Immune Microenvironment in the Mmrf Commpass Study (2020) (2)
- Transplantation of adipose‐derived stem cells combined with collagen bioengineering scaffold upregulates vascular endothelial growth factor expression in rats with chronic refractory wound (2018) (2)
- Cross center single-cell RNA sequencing study of the immune microenvironment in rapid progressing multiple myeloma (2023) (2)
- Co-survival of the fittest few: mosaic amplification of receptor tyrosine kinases in glioblastoma (2012) (2)
- PDXNet Portal: Patient-Derived Xenograft model, data, workflow, and tool discovery (2021) (2)
- Proteogenomic Characterization of Ovarian HGSC Implicates Mitotic Kinases, Replication Stress in Observed Chromosomal Instability (2020) (1)
- [Efficacy and safety of insulin degludec for diabetes mellitus: a meta-analysis]. (2016) (1)
- Safety and efficacy of technetium-99 methylene diphosphate combined with glucocorticoid for Graves ophthalmopathy (2016) (1)
- Characterization of T-Cell Exhaustion in Rapid Progressing Multiple Myeloma Using Cross Center Scrna-Seq Study (2021) (1)
- Experimental study and normal individual trial of hemopoietic stem cell mobilizer ds (1992) (1)
- Abstract 3438: Integrated analysis of germline and somatic variants in renal clear cell carcinoma (2014) (1)
- Single-Cell Pathway Enrichment and Regulatory Profiling of Multiple Myeloma across Disease Stages (2019) (1)
- Whole Genome Sequencing of Therapy-Related Acute Myeloid Leukemia (2012) (1)
- BreakTrans: uncovering the genomic architecture of gene fusions (2013) (1)
- Single-Cell Transcriptomic and Proteomic Diversity in Multiple Myeloma (2019) (1)
- Abstract 5123: Proteogenomic characterization reveals mitotic kinase and replication stress implicated in ovarian high-grade serous cancer (2020) (1)
- Sequencing an Acute Myeloid Leukemia (AML) Genome with “Next Generation” Technologies. (2007) (1)
- Abstract PR03: The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma (2014) (1)
- Supplementary Appendix for "Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia" (2014) (1)
- Whole genome sequencing to characterize luminal-type breast cancer. (2012) (1)
- Retrospective analysis of circulating tumor DNA of archived plasma samples. (2016) (1)
- The effects of common structural variants on 3D chromatin structure (2020) (1)
- Expression of an Oncogenic ERG isoform Characterizes a Distinct Subtype of B-Progenitor Acute Lymphoblastic Leukemia (2015) (1)
- Curative Effect of Hyperbaric Oxygen for Infants with Cerebral Palsy:A Report of 84 Cases (2007) (1)
- Whole exome sequencing reveals the maintained polyclonal nature from primary to metastatic malignant peripheral nerve sheath tumor in two patients with NF1 (2019) (1)
- AeQTL: eQTL analysis using region-based aggregation of rare genomic variants (2020) (1)
- Detection of Novel Mutations In MDS/AML by Whole Genome Sequencing (2010) (1)
- NF 1-associated pilocytic astrocytoma Somatic neurofibromatosis type 1 ( NF 1 ) inactivation characterizes Material Supplemental (2013) (1)
- Abstract 61: Sequence and structure-guided approach to identify functional mutations in G-protein coupled receptors (2015) (1)
- Mutations In the DNA Methyltransferase Gene DNMT3A Are Highly Recurrent In Patients with Intermediate Risk Acute Myeloid Leukemia, and Predict Poor Outcomes (2010) (1)
- Abstract LB-87: Analysis of luminal-type breast cancer by massively parallel sequencing (2011) (1)
- Co-survival of the fittest few: mosaic amplification of receptor tyrosine kinases in glioblastoma (2012) (1)
- Erratum: Differences that matter in cancer genomics (2013) (1)
- Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma (2023) (1)
- Yolk Sac Tumor Originating From Cervical Adenocarcinoma: A Case Predominated by Enteroblastic Differentiation. (2022) (1)
- Massive parallel sequencing of an African-American basal-like breast cancer: Comparison of primary tumor, metastasis, and xenograft. (2010) (0)
- Abstract 3424: Genomic alterations in clonal hematopoiesis (2018) (0)
- Deep Digital Sequencing Identifies an AML Subclone with Enhanced in Vitro and in Vivo Growth Properties Associated with Disease Relapse (2012) (0)
- Abstract LB-006: Proteogenomic characterization of human colon cancer reveals new therapeutic opportunities (2019) (0)
- Abstract 1929: Pan-Cancer analysis of the effects of splice-altering variants on mRNA splicing and stability (2015) (0)
- Resource Reveals Molecular Classification Multiplatform Analysis of 12 Cancer Types within and across Tissues of Origin (0)
- A dominant mutation in RPE65 identified by whole-exome sequencing causes retinitis pigmentosa with choroidal involvement (2011) (0)
- Visualizing tumor evolution with the fishplot package for R (2016) (0)
- Next-Generation Sequencing: A Discovery Tool for Blood Disorders (2012) (0)
- Abstract 2362: Comprehensive portrait of canonical and non-canonical splicing in cancer (2018) (0)
- Author Correction: Patterns of somatic structural variation in human cancer genomes (2020) (0)
- Identification and Validation of CD138- Multiple Myeloma Immune and Tumor Subpopulations Using Cross Center Scrna-Seq Data (2020) (0)
- Abstract 3170: Identification of novel genetic alterations driving melanoma tumorigenesis. (2013) (0)
- Abstract LB-239: Mutational and clonal analyses across TCGA cancer types using the MuSiC suite of tools. (2013) (0)
- Precancerous Clonal Expansion: A New Therapeutic Target? (2017) (0)
- Abstract IA2: Genomic comparisons of coincident prostate cancer foci (2012) (0)
- Myeloma Cell Associated Therapeutic Protein Discovery Using Single Cell RNA-Seq Data (2020) (0)
- Abstract 3873: Profiling the tumor microenvironment within clear cell renal cell carcinoma by single-nuclei RNA-Seq (2022) (0)
- DNA Sequencing of a Murine Acute Promyelocytic Leukemia (APL) Genome Using Next Generation Technology. (2009) (0)
- Derivation of Distinct Prognostic Tumor Cell States in PDAC via Single-Cell RNA Sequencing. (2021) (0)
- Integrated genomic characterization of oesophageal carcinoma (2017) (0)
- Abstract 4017: Defining cell type-specific pathways in both cancer and tumor-microenvironment cells that impact survival of clear cell renal carcinoma patients (2022) (0)
- Abstract 159: Pancreatic ductal adenocarcinoma developmental cell state signatures identified by single cell RNA sequencing are prognostic when applied to bulk RNA-seq data (2021) (0)
- Abstract 4873: Comprehensive analysis of 160 whole-genome sequences reveals striking telomere alteration patterns in 9 pediatric cancers (2012) (0)
- Abstract 357: CYP3A4 Activates Stat3 in ER + breast cancer (2011) (0)
- LGG Nat Genet Supplemental data 2013 (2013) (0)
- Abstract 419: Reproducibility assessment of mutations calls in exome- and whole-genome sequencing using consensus calling from TCGA and ICGC (2018) (0)
- Abstract SY44-02: Proteogenomic and phosphoproteomic analysis of breast cancer (2015) (0)
- Author Correction: Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment (2022) (0)
- Abstract 1306: Density-based mutation clustering in 3D space (2018) (0)
- Clonal Hematopoiesis and Risk of Incident Lung Cancer (2022) (0)
- Combining accurate tumor genome simulation with crowdsourcing to benchmark somatic structural variant detection (2018) (0)
- Resolution of a Clinical Dilemma with Whole Genome Sequencing, and Discovery of a New Mechanism for Generating PML-Rara: Insertional Fusion (2010) (0)
- Characterization of Germline Variants in Multiple Myeloma (2018) (0)
- Influence of atorvastatin in depressive symptoms in patients with cerebral infarction (2012) (0)
- Abstract 2706: Effects of germline and somatic mutations on protein expression in tumor and adjacent normal tissues in breast, ovarian, and colorectal tumors (2018) (0)
- Abstract B11: The MuSiC2 system for discovery and visualization of coding and noncoding cancer drivers (2018) (0)
- Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma (2023) (0)
- Abstract 442:RASA1alteration promotes melanoma tumorigenesis (2014) (0)
- Erratum: The Pediatric Cancer Genome Project (2012) (0)
- Abstract 1863: Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation (2016) (0)
- Comparison Study of Three Different Treatments on Condyloma Acuminatum (2001) (0)
- Abstract LB-267: The proteomic landscape of patient-derived breast cancer xenografts reveals tumor-specific differences in the breast tumor microenvironment (2016) (0)
- Abstract 445: Integrated proteogenomic characterization across seven histological types of pediatric brain tumors (2020) (0)
- Whole Genome Sequencing Reveals Novel Recurring Somatic Mutations Affecting HUWE1 and DIAPH2 Genes in Multiple Myeloma (2012) (0)
- Abstract IA29: Proteogenomic and phosphoproteomic analysis of breast cancer (2016) (0)
- Abstract LB-265: Patient-derived xenografts from advanced luminal-type breast cancer: insights into endocrine therapy resistance. (2013) (0)
- Abstract 794: Pan-cancer proteogenomic analysis reveals functional mechanisms underlying DNA repair deficiencies (2022) (0)
- Abstract 4424: Medatree enabling single cell copy number lineage tracing and functional discovery (2020) (0)
- Abstract A05: Identification of RASA1 as a novel melanoma tumor suppressor gene (2015) (0)
- Abstract PO-017: Single-cell copy number heterogeneity tracing enabling cancer gene discovery (2020) (0)
- Abstract A60: Integrated proteogenomic characterization of pancreatic ductal adenocarcinoma (2019) (0)
- Abstract 4867: Identification of an inv(16)-encodedCBFA2T3-GLIS2fusion protein in 34% of non-infant acute megkaryoblastic leukemias: A report from the Pediatric Cancer Genome Project (2012) (0)
- Abstract 5895: Whole-genome characterization of lung adenocarcinomas lacking alterations in RTK/RAS/RAF/MAPK pathway (2020) (0)
- Corrigendum: Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis (2017) (0)
- Fusion gene detection across a large cohort of multiple myeloma patients (2019) (0)
- Abstract 3193: A new approach for colocalization of proteins using HRP and AP enzyme detection in paraffin embedded tissues (2012) (0)
- GENE-19. DEEP PROTEOMIC SURVEY ACROSS SEVEN CHILDHOOD BRAIN TUMORS (2019) (0)
- Abstract C200: Effects of PI3K/Akt pathway inhibition on global proteome levels and phosphorylation signaling in patient-derived xenograft models of triple negative breast cancer (2015) (0)
- Abstract 1729: Single-cell transcriptome profiling of multiple myeloma bone marrow samples suggests that disease progression interplays with tumor and tumor microenvironment in The MMRF CoMMpass Study (2022) (0)
- Abstract LB-232: Tumor clonality detection using next generation sequencing data. (2013) (0)
- Resource Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities Graphical (0)
- Characterization of Plasma and Immune Cells Molecular Landscape That Play a Role in Rapid Progression of Multiple Myeloma Using Cross Center Scrna-Seq Study (2020) (0)
- MOMC-4. Proteogenomic and metabolomic characterization of glioblastoma (2021) (0)
- Analysis of the mechanism underlying the effects of cyclophosphamide against triple-negative breast cancer by an integrative bioinformatics approach (2021) (0)
- Urine- and Plasma-Based Detection of Minimal Residual Disease in Localized Bladder Cancer Patients. (2021) (0)
- SC2MeNetDrug: A computational tool to uncover inter-cell signaling targets and identify relevant drugs based on single cell RNA-seq data (2021) (0)
- Comprehensive Multi-Omics Analysis of Gene Fusions in a Large Multiple Myeloma Cohort (2018) (0)
- Abstract 5027: PTMcosmos: A web portal of post-translational modifications and proteogenomic resources in cancer (2022) (0)
- DNA Sequence of the Cancer Genome of a Patient with Therapy-Related Acute Myeloid Leukemia (2010) (0)
- Charting the Spatial Landscape of Cancer Hallmarks (2022) (0)
- Abstract 1285: Analysis of esophageal cancer SNPs and gene expression to predict ESCC risk (2017) (0)
- Transcriptome Sequence Analysis of Pediatric Acute Megakaryoblastic Leukemia Identifies An Inv(16)(p13.3;q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein As a Recurrent Lesion in 39% of Non-Infant Cases: A Report From the St. Jude Children's Research Hospital – Washington University Pediatric Cancer Geno (2011) (0)
- Thread 1: Mutational drivers (2013) (0)
- Clinical effects of low molecular weight heparin of treatment for unstable angina (2002) (0)
- Abstract 1118: Absence of mouse-specific tumor evolution in patient-derived cancer xenografts (2020) (0)
- Tracking minimal residual disease with urine tumor DNA in muscle-invasive bladder cancer after neoadjuvant chemotherapy. (2021) (0)
- assembly TIGRA : A targeted iterative graph routing assembler for breakpoint Material (2015) (0)
- Supplementary Materials for Landscape of Somatic Retrotransposition in Human Cancers (2012) (0)
- Uncovering Clonal and Subclonal Druggable Targets in Multiple Myeloma Using Omic Data (2016) (0)
- The pathogeny and electromyography of myokymia (2010) (0)
- Abstract 5118: Proteogenomics characterization of HPV-negative head and neck squamous cell carcinomas (2020) (0)
- Observation of Curative Effect of Self-made Relieving Depression Decoction Combined with Fluoxetine in Treatment of Depression (2012) (0)
- Clinical observation of low molecular weight heparin in the treatment of unstable angina pectoris (2001) (0)
- The effect of Edaravone on MMP-2、MMP-9 and neurologic impairment during the treatment of acute cerebral infarction (2013) (0)
- 242 Genomics of myelodysplastic syndromes (2011) (0)
- Abstract 2357: Utilizing biological and protein structure-guided features to improve driver mutation discovery (2018) (0)
- IntOGen - TCGA pan-cancer12 high confidence drivers (2013) (0)
- Detection of membrane neutrophil alkaline phosphatase in diagnosis of infection in patients with acute cerebral hemorrhage (2016) (0)
- Integrated transcriptomic–genomic tool Texomer profiles cancer tissues (2019) (0)
- Integrative omics analyses broaden treatment targets in human cancer (2018) (0)
- High-dimensional deconstruction of pancreatic ductal adenocarcinoma identifies tumor microenvironmental communities associated with survival (2022) (0)
- Clinical application of phosphate sitagliptin in the treatment of senile type 2 diabetes (2013) (0)
- Improvement effect of short-term intensive insulin treatment on vascular endothelial function of diabetes patients (2017) (0)
- Rescue and nursing of severe brain injury patients having secondary innominate artery hemorrhage after tracheal incision: a case study (2016) (0)
- Tangential excision and dermabrasion in treatment of superficial giant congenital melanocytic nevus (2011) (0)
- Pan-cancer analysis of somatic mutations across 21 neuroendocrine tumor types (2018) (0)
- Therapeutic Drugs for Hemorrhoids (2009) (0)
- Abstract 477: High-dimensional analysis to deconstruct pancreatic ductal adenocarcinoma and identify tumor cellular communities with prognostic and potentially predictive value (2022) (0)
- Efficacy of ozagrel combined with puerarin used in acute cerebral infarction (2009) (0)
- Clinical observation on the therapeutic effect of edaravone therapy on brain traumatic cerebral vasospams patients (2012) (0)
- Effect of hyperbaric oxygen combined with intravenous drugs in the treatment of 130 cases of brain vessel diseases (2005) (0)
- Advances in research of the evaluation and management of mild traumatic brain (2016) (0)
- Observation on the effects of hypesbaric oxygen combined with mecobalamin on electrophysiological changes in the treatment of carpal tunnel syndrome (2016) (0)
- Clininal analysis of Qumei trimetazidine treatment of Coronary heart disease and heart failur (2013) (0)
- Research progresses on the pathophysiology of hemorrhoidal diseases (2010) (0)
- Comparative analysis between the transradial and transfemoral approach coronary intervention (2010) (0)
- Expression of MACC1-1 and c-Met in human prostatic cancer and their clinicopathological significance (2016) (0)
- Fever burden independently contributes to increased poor outcome of patients with traumatic brain injury (2014) (0)
- Angiotensin-converting enzyme ( insertion / deletion ) gene polymorphism does not contribute to sporadic Alzheimer ’ s disease risk in caucasian individuals : a meta-analysis (2017) (0)
- Correlation between the microembolic signals and the outcomes in patients with cardiogenic cerebral embolism (2016) (0)
- Effects of hyperbaric oxygen on the cognition of the patients with stroke during the acute stage of cerebral infarction (2018) (0)
- CaSR polymorphisms and risk of nephrolithiasis: A meta analysis (2019) (0)
- Abstract 1118: High-dimensional deconstruction of pancreatic cancer identifies co-occurring TME features associated with survival (2023) (0)
- Single-Cell RNA-Seq Analysis of CD138-Depleted Bone Marrow Samples Reveals Genetic Alterations and Disease Progression Correlate with Tumor and Bone Marrow Immune Microenvironment in the Mmrf Commpass Study (2021) (0)
- Use of whole genome sequencing to identify novel mutations in distinct subgroups of medulloblastoma. (2012) (0)
- Abstract 1999: Proteogenomic characterization of breast cancer sub-types in patient derived xenografts (2015) (0)
- Abstract B12: Complete characterization of the “microRNAome” of a human acute myeloid leukemia (2010) (0)
- Abstract 1939: Discovery and proteogenomic investigation of genetic variants in human cancers (2015) (0)
- Abstract 4106: Curating protein complexes from multiple resources and validate their co-regulations at RNA/protein level in pan-cancer (2022) (0)
- Abstract ES7-1: Next Generation Sequencing for the Clinician: A Breast Cancer Study (2010) (0)
- Abstract 2025: Spatial transcriptomic profiling of progression markers in clear cell renal cell carcinoma (2022) (0)
- Driver Fusions and Their I mplications in the Development and Treatment of Human Cancers Graphical (2018) (0)
- Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples (2020) (0)
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