Lina M. Obeid
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American physician and cander researcher
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Lina M. Obeidbiology Degrees
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Lina M. Obeidphilosophy Degrees
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Biology Philosophy
Lina M. Obeid's Degrees
- Doctorate Medicine University of Chicago
- PhD Biochemistry University of Chicago
Why Is Lina M. Obeid Influential?
(Suggest an Edit or Addition)According to Wikipedia, Lina M. Obeid was an American physician and cancer researcher. Early life Lina Marie Obeid was born in New York and raised in Lebanon, the daughter of Dr. Sami Obeid, a renowned Lebanese surgeon, and Rosette Z. Obeid, a Palestinian writer and cookbook author. Obeid earned a bachelor's degree in chemistry from Rutgers University. She earned her medical degree at the American University of Beirut in 1983.
Lina M. Obeid's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Principles of bioactive lipid signalling: lessons from sphingolipids (2008) (2845)
- Programmed cell death induced by ceramide. (1993) (1715)
- Sphingolipids and their metabolism in physiology and disease (2017) (912)
- The Ceramide-centric Universe of Lipid-mediated Cell Regulation: Stress Encounters of the Lipid Kind* (2002) (871)
- An overview of sphingolipid metabolism: from synthesis to breakdown. (2010) (799)
- Ceramide: an intracellular signal for apoptosis. (1995) (601)
- Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation. (1991) (563)
- Role for Ceramide in Cell Cycle Arrest (*) (1995) (486)
- Role of Ceramide in Cellular Senescence (*) (1995) (448)
- Ceramide synthases at the centre of sphingolipid metabolism and biology. (2012) (403)
- Thioredoxin Peroxidase Is a Novel Inhibitor of Apoptosis with a Mechanism Distinct from That of Bcl-2* (1997) (384)
- Many Ceramides* (2011) (365)
- Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis (2012) (362)
- Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. (2008) (361)
- Glutathione Regulation of Neutral Sphingomyelinase in Tumor Necrosis Factor-α-induced Cell Death* (1998) (351)
- De Novo Ceramide Regulates the Alternative Splicing of Caspase 9 and Bcl-x in A549 Lung Adenocarcinoma Cells (2002) (337)
- PKC-dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane (2002) (308)
- The sphingosine kinase 1/sphingosine‐1‐phosphate pathway mediates COX‐2 induction and PGE2 production in response to TNF‐α (2003) (300)
- Sphingosine kinase: biochemical and cellular regulation and role in disease. (2006) (294)
- Bcl-2 interrupts the ceramide-mediated pathway of cell death. (1996) (293)
- Involvement of Yeast Sphingolipids in the Heat Stress Response of Saccharomyces cerevisiae * (1997) (291)
- Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide. (1993) (289)
- A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death. (2006) (287)
- Inhibition of Tumor Necrosis Factor-induced Cell Death in MCF7 by a Novel Inhibitor of Neutral Sphingomyelinase* (2002) (281)
- Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. (1994) (277)
- Role for sphingosine kinase 1 in colon carcinogenesis (2009) (263)
- Ceramide Inactivates Cellular Protein Kinase Cα* (1996) (262)
- Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis (2001) (243)
- Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. (1995) (227)
- Ceramide: A stress signal and mediator of growth suppression and apoptosis (1995) (224)
- Alterations of Ceramide/Sphingosine 1-Phosphate Rheostat Involved in the Regulation of Resistance to Imatinib-induced Apoptosis in K562 Human Chronic Myeloid Leukemia Cells* (2007) (218)
- Sphingosine kinase 1 is up‐regulated in colon carcinogenesis (2006) (213)
- Cytokine Response Modifier A (CrmA) Inhibits Ceramide Formation in Response to Tumor Necrosis Factor (TNF)-α: CrmA and Bcl-2 Target Distinct Components in the Apoptotic Pathway (1997) (212)
- prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2. (1996) (209)
- Defects in Cell Growth Regulation by C18:0-Ceramide and Longevity Assurance Gene 1 in Human Head and Neck Squamous Cell Carcinomas* (2004) (206)
- Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B. (1993) (201)
- Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy. (2004) (200)
- Ceramide: an endogenous regulator of apoptosis and growth suppression. (1995) (195)
- Biochemical Mechanisms of the Generation of Endogenous Long Chain Ceramide in Response to Exogenous Short Chain Ceramide in the A549 Human Lung Adenocarcinoma Cell Line (2002) (190)
- Immunohistochemical Distribution of Sphingosine Kinase 1 in Normal and Tumor Lung Tissue (2005) (189)
- Cloning of an Alkaline Ceramidase from Saccharomyces cerevisiae (2000) (186)
- A role for sphingosine kinase 1 in dextran sulfate sodium‐induced colitis (2009) (184)
- Ceramide and apoptosis: exploring the enigmatic connections between sphingolipid metabolism and programmed cell death. (2012) (173)
- Regulation of protein kinase C and role in cancer biology (1994) (173)
- Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha. (1993) (168)
- p53-dependent ceramide response to genotoxic stress. (1998) (162)
- Activation of sphingosine‐1‐phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration (2007) (162)
- The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. (2003) (162)
- Role of Human Sphingosine-1-phosphate Phosphatase 1 in the Regulation of Intra- and Extracellular Sphingosine-1-phosphate Levels and Cell Viability* (2003) (160)
- Expression of Neutral Sphingomyelinase Identifies a Distinct Pool of Sphingomyelin Involved in Apoptosis* (1997) (158)
- Identification and Characterization of Saccharomyces cerevisiae Dihydrosphingosine-1-phosphate Phosphatase* (1997) (157)
- Mitochondria and ceramide: intertwined roles in regulation of apoptosis. (2002) (156)
- Bioactive sphingolipids in the modulation of the inflammatory response. (2006) (155)
- Cloning and Characterization of a Saccharomyces cerevisiae Alkaline Ceramidase with Specificity for Dihydroceramide* (2000) (152)
- Role for Mammalian Neutral Sphingomyelinase 2 in Confluence-induced Growth Arrest of MCF7 Cells* (2004) (151)
- Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation. (2010) (150)
- Involvement of Dihydroceramide Desaturase in Cell Cycle Progression in Human Neuroblastoma Cells* (2007) (150)
- The Mechanism of Membrane Targeting of Human Sphingosine Kinase 1* (2005) (150)
- A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria. (2005) (146)
- Loss of sphingosine kinase‐1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis (2006) (145)
- JNK3 Signaling Pathway Activates Ceramide Synthase Leading to Mitochondrial Dysfunction* (2007) (144)
- The Coordination of Prostaglandin E2 Production by Sphingosine-1-phosphate and Ceramide-1-phosphate (2005) (143)
- Sphingosine Kinase 1 (SPHK1) Is Induced by Transforming Growth Factor-β and Mediates TIMP-1 Up-regulation* (2004) (140)
- Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase 3 in colon cancer cells (2008) (136)
- Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis (2012) (136)
- Down-regulation of Sphingosine Kinase-1 by DNA Damage (2004) (136)
- Protein kinase C isoenzymes: regulation and function. (1996) (135)
- Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P (2006) (133)
- Ceramide Inhibits Phospholipase D in a Cell-free System* (1996) (133)
- A Deficiency of Ceramide Biosynthesis Causes Cerebellar Purkinje Cell Neurodegeneration and Lipofuscin Accumulation (2011) (132)
- Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets. (2017) (132)
- Yeast sphingolipids: recent developments in understanding biosynthesis, regulation, and function. (2007) (131)
- Yeast sphingolipids: metabolism and biology. (2002) (129)
- Rapid Shortening of Telomere Length in Response to Ceramide Involves the Inhibition of Telomere Binding Activity of Nuclear Glyceraldehyde-3-phosphate Dehydrogenase* (2004) (128)
- Transcriptional regulation of protein kinase C by 1,25-dihydroxyvitamin D3 in HL-60 cells. (1990) (128)
- Cloning and Characterization of a Novel Human Alkaline Ceramidase (2001) (125)
- Sphingolipids Signal Heat Stress-induced Ubiquitin-dependent Proteolysis* (2000) (122)
- Role of Ceramide in Mediating the Inhibition of Telomerase Activity in A549 Human Lung Adenocarcinoma Cells* (2001) (119)
- The BCL-2 Protein BAK Is Required for Long-chain Ceramide Generation during Apoptosis* (2010) (118)
- Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence. (1994) (117)
- Sphingosine Kinase 1 Is Up-regulated during Hypoxia in U87MG Glioma Cells (2008) (117)
- The Development and Maintenance of Paclitaxel-induced Neuropathic Pain Require Activation of the Sphingosine 1-Phosphate Receptor Subtype 1* (2014) (115)
- Selective Involvement of Ceramide in Cytokine-induced Apoptosis (1997) (114)
- Positively Charged Ceramide Is a Potent Inducer of Mitochondrial Permeabilization* (2005) (114)
- Necessary Role for the Lag1p Motif in (Dihydro)ceramide Synthase Activity* (2006) (113)
- The functional effects of acid ceramidase over-expression in prostate cancer progression and resistance to chemotherapy (2007) (109)
- Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: review of sphingosine kinase inhibitors. (2013) (107)
- Sphingosine‐1‐phosphate receptor 2 (2013) (107)
- Identification of Dihydroceramide Desaturase as a Direct in Vitro Target for Fenretinide* (2011) (106)
- Evolving concepts in cancer therapy through targeting sphingolipid metabolism. (2014) (106)
- Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism[S] (2011) (105)
- Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response. (2009) (105)
- Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. (2011) (104)
- AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells (2009) (102)
- The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. (1999) (102)
- Molecular Mechanisms of Ceramide-mediated Telomerase Inhibition in the A549 Human Lung Adenocarcinoma Cell Line* (2001) (101)
- Insulin-like Growth Factors Mediate Heterotrimeric G Protein-dependent ERK1/2 Activation by Transactivating Sphingosine 1-Phosphate Receptors* (2006) (101)
- Cystic Fibrosis Transmembrane Regulator Regulates Uptake of Sphingoid Base Phosphates and Lysophosphatidic Acid (2001) (99)
- Hyaluronan Constitutively Regulates Activation of COX-2-mediated Cell Survival Activity in Intestinal Epithelial and Colon Carcinoma Cells* (2008) (98)
- Role of sphingosine kinase‐1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro (2010) (98)
- Phytosphingosine as a Specific Inhibitor of Growth and Nutrient Import in Saccharomyces cerevisiae * (2001) (98)
- Ceramide Synthase-dependent Ceramide Generation and Programmed Cell Death (2011) (96)
- Golgi fragmentation is associated with ceramide-induced cellular effects. (2005) (94)
- Novel Pathway of Ceramide Production in Mitochondria (2011) (93)
- Role of sphingolipids in senescence: implication in aging and age‐related diseases (2018) (91)
- Potent Antitumor Activity of a Novel Cationic Pyridinium-Ceramide Alone or in Combination with Gemcitabine against Human Head and Neck Squamous Cell Carcinomas in Vitro and in Vivo (2006) (91)
- Sphingosine kinase 1 in cancer. (2013) (91)
- Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages. (2008) (90)
- Tumor Necrosis Factor Induces the Loss of Sphingosine Kinase-1 by a Cathepsin B-dependent Mechanism* (2005) (88)
- Regulation of cyclin-dependent kinase 2 activity by ceramide. (2000) (88)
- Isc1 regulates sphingolipid metabolism in yeast mitochondria. (2007) (88)
- Genetic Sphingosine Kinase 1 Deficiency Significantly Decreases Synovial Inflammation and Joint Erosions in Murine TNF-α–Induced Arthritis (2010) (82)
- Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes. (2008) (82)
- Sphingolipids in mitochondria. (2017) (82)
- A novel role for protein kinase Cδ‐mediated phosphorylation of acid sphingomyelinase in UV light‐induced mitochondrial injury (2008) (78)
- Sphingosine Kinase 1 (SK1) Is Recruited to Nascent Phagosomes in Human Macrophages: Inhibition of SK1 Translocation by Mycobacterium tuberculosis1 (2005) (77)
- Ceramide Generated by Sphingomyelin Hydrolysis and the Salvage Pathway Is Involved in Hypoxia/Reoxygenation-induced Bax Redistribution to Mitochondria in NT-2 Cells* (2008) (77)
- Developmentally Regulated Ceramide Synthase 6 Increases Mitochondrial Ca2+ Loading Capacity and Promotes Apoptosis* (2010) (76)
- Sphingosine-1-phosphate Signaling Promotes Critical Migratory Events in Vasculogenesis* (2004) (72)
- Inhibition of Caspases Inhibits the Release of Apoptotic Bodies: Bcl-2 Inhibits the Initiation of Formation of Apoptotic Bodies in Chemotherapeutic Agent-induced Apoptosis (1999) (71)
- Effects of sphingosine and other sphingolipids on protein kinase C. (2000) (71)
- A Role of Sphingosine Kinase 1 in Head and Neck Carcinogenesis (2011) (70)
- Alkaline Ceramidase 3 (ACER3) Hydrolyzes Unsaturated Long-chain Ceramides, and Its Down-regulation Inhibits Both Cell Proliferation and Apoptosis* (2010) (69)
- Defining a role for sphingosine kinase 1 in p53-dependent tumors (2011) (69)
- Phorbol myristate acetate-dependent association of protein kinase C alpha with phospholipase D1 in intact cells. (1997) (69)
- Ceramide: a novel lipid mediator of apoptosis. (1997) (69)
- Ceramide and the eukaryotic stress response. (1997) (68)
- Upregulation of Bcl-2 and elevation of ceramide in Batten disease. (1997) (68)
- ISC1-dependent Metabolic Adaptation Reveals an Indispensable Role for Mitochondria in Induction of Nuclear Genes during the Diauxic Shift in Saccharomyces cerevisiae* (2009) (66)
- Molecular targeting of acid ceramidase: implications to cancer therapy. (2008) (66)
- Differential Effects of Ceramide and Sphingosine 1-Phosphate on ERM Phosphorylation (2010) (66)
- Yeast sphingolipid metabolism: clues and connections. (2004) (65)
- Protein Kinase C-induced Activation of a Ceramide/Protein Phosphatase 1 Pathway Leading to Dephosphorylation of p38 MAPK* (2006) (65)
- 5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools. (1991) (65)
- Phospholipase D in cellular senescence. (1999) (65)
- Mechanisms of ceramide-mediated apoptosis. (1997) (64)
- The Insulin-like Growth Factor Type 1 and Insulin-like Growth Factor Type 2/Mannose-6-phosphate Receptors Independently Regulate ERK1/2 Activity in HEK293 Cells* (2007) (64)
- Acid Ceramidase but Not Acid Sphingomyelinase Is Required for Tumor Necrosis Factor-α-induced PGE2 Production* (2006) (63)
- Functional Dichotomy of Protein Kinase C (PKC) in Tumor Necrosis Factor-α (TNF-α) Signal Transduction in L929 Cells (2000) (61)
- Dihydroceramide-based Response to Hypoxia* (2011) (61)
- Intracellular sphingosine kinase 2‐derived sphingosine‐1‐phosphate mediates epidermal growth factor‐induced ezrin‐radixin‐moesin phosphorylation and cancer cell invasion (2015) (61)
- Cell-cycle-dependent changes in ceramide levels preceding retinoblastoma protein dephosphorylation in G2/M. (1998) (61)
- Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation (2017) (60)
- Murine Model for Colitis-Associated Cancer of the Colon. (2016) (59)
- De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation. (2008) (59)
- Tailoring structure-function and targeting properties of ceramides by site-specific cationization. (2006) (58)
- Dihydrosphingosine 1‐phosphate stimulates MMP1 gene expression via activation of ERK1/2‐Ets1 pathway in human fibroblasts (2006) (58)
- Ceramidases in the regulation of ceramide levels and function. (2002) (58)
- Regulation of protein kinase C (PKC) expression by iron: effect of different iron compounds on PKC-beta and PKC-alpha gene expression and role of the 5'-flanking region of the PKC-beta gene in the response to ferric transferrin. (1994) (58)
- Combined therapeutic use of AdGFPFasL and small molecule inhibitors of ceramide metabolism in prostate and head and neck cancers: a status report (2006) (57)
- Ceramide, stress, and a "LAG" in aging. (2003) (57)
- Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells (2006) (57)
- Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis Published, JLR Papers in Press, February 13, 2006. (2006) (57)
- Long-chain acyl-CoA synthetase 1 interacts with key proteins that activate and direct fatty acids into niche hepatic pathways (2018) (56)
- Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. (2013) (56)
- Sphingolipid regulation of ezrin, radixin, and moesin proteins family: implications for cell dynamics. (2014) (56)
- Cloning and Characterization of a Mouse Endoplasmic Reticulum Alkaline Ceramidase (2003) (56)
- Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters. (1992) (55)
- Modulation of Transforming Growth Factor-β (TGF-β) Signaling by Endogenous Sphingolipid Mediators* (2003) (54)
- P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest (2015) (53)
- The novel second messenger ceramide: identification, mechanism of action, and cellular activity. (1993) (53)
- CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid‐specific cancer cell death through autophagy induction (2012) (52)
- Ceramide: an intracellular mediator of apoptosis and growth suppression. (1996) (52)
- P38 delta MAPK promotes breast cancer progression and lung metastasis by enhancing cell proliferation and cell detachment (2017) (52)
- Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid. (2009) (51)
- A novel role of sphingosine kinase‐1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma (2015) (49)
- Substrate Specificity, Membrane Topology, and Activity Regulation of Human Alkaline Ceramidase 2 (ACER2)* (2010) (49)
- Selective regulation of expression of protein kinase C beta isoenzymes occurs via alternative splicing. (1993) (48)
- Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis (2011) (47)
- Role of neutral ceramidase in colon cancer (2016) (47)
- Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl 1 stability and drug resistance by modulation of protein phosphatase 2 A * (2011) (47)
- Oxidized LDL immune complexes induce release of sphingosine kinase in human U937 monocytic cells. (2006) (47)
- Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease. (2012) (47)
- Alkaline Ceramidase 2 (ACER2) and Its Product Dihydrosphingosine Mediate the Cytotoxicity of N-(4-Hydroxyphenyl)retinamide in Tumor Cells* (2010) (46)
- Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2 (2017) (45)
- Long-chain Ceramide Is a Potent Inhibitor of the Mitochondrial Permeability Transition Pore* (2008) (44)
- Involvement of Acid β-Glucosidase 1 in the Salvage Pathway of Ceramide Formation* (2009) (44)
- Sphingolipids in the DNA damage response. (2015) (44)
- Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase. (2015) (43)
- Insulin regulates protein kinase CbetaII expression through enhanced exon inclusion in L6 skeletal muscle cells. A novel mechanism of insulin- and insulin-like growth factor-i-induced 5' splice site selection. (1998) (42)
- Sphingolipids in neutrophil function and inflammatory responses: Mechanisms and implications for intestinal immunity and inflammation in ulcerative colitis. (2017) (41)
- Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system (2016) (41)
- Involvement of endogenous ceramide in the inhibition of telomerase activity and induction of morphologic differentiation in response to all-trans-retinoic acid in human neuroblastoma cells. (2003) (41)
- Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death* (2015) (40)
- Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes (2010) (40)
- Accumulation of Long-Chain Glycosphingolipids during Aging Is Prevented by Caloric Restriction (2011) (40)
- Bcl-2 acts upstream of the PARP protease and prevents its activation (1997) (39)
- Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy (2011) (39)
- Sphingosine Kinase 1 Is Regulated by Peroxisome Proliferator-activated Receptor α in Response to Free Fatty Acids and Is Essential for Skeletal Muscle Interleukin-6 Production and Signaling in Diet-induced Obesity* (2013) (38)
- Oncogenic K-Ras Regulates Bioactive Sphingolipids in a Sphingosine Kinase 1-dependent Manner* (2012) (38)
- Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells (2005) (37)
- Epidermal growth factor‐induced cellular invasion requires sphingosine‐1‐phosphate/sphingosine‐1‐phosphate 2 receptor‐mediated ezrin activation (2013) (37)
- Specific role for protein kinase C beta in cell differentiation. (1994) (37)
- A novel assay for apoptotic body formation and membrane release during apoptosis. (1999) (36)
- Regulation of membrane release in apoptosis. (1998) (36)
- Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain (2015) (36)
- Alkaline ceramidase 2 regulates β1 integrin maturation and cell adhesion (2009) (35)
- Combination of C(17) sphingoid base homologues and mass spectrometry analysis as a new approach to study sphingolipid metabolism. (2007) (34)
- Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response (2016) (33)
- Sphingosine 1-Phosphate and Sphingosine Kinase Are Involved in a Novel Signaling Pathway Leading to Acrosomal Exocytosis* (2010) (33)
- Regulation of CC Ligand 5/RANTES by Acid Sphingomyelinase and Acid Ceramidase* (2011) (32)
- Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury (2017) (32)
- Intraplantar‐injected ceramide in rats induces hyperalgesia through an NF‐κB‐ and p38 kinase‐dependent cyclooxygenase 2/prostaglandin E2 pathway (2011) (32)
- Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis (2013) (32)
- Sphingosine kinase‐1 is cleaved by cathepsin B in vitro: Identification of the initial cleavage sites for the protease (2006) (32)
- Regulation of the sphingosine kinase/sphingosine 1-phosphate pathway. (2013) (31)
- Modulation of total Akt kinase by increased expression of a single isoform: requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGF-dependent expression of Akt3 in primary endothelial cells. (2006) (31)
- The Localization and Activity of Sphingosine Kinase 1 Are Coordinately Regulated with Actin Cytoskeletal Dynamics in Macrophages* (2007) (31)
- Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-α (2020) (31)
- Inhibition of Sphingosine Kinase-2 in a Murine Model of Lupus Nephritis (2013) (30)
- p53 and regulation of bioactive sphingolipids. (2011) (29)
- Sphingosine-1-phosphate acting via the S1P1 receptor is a downstream signaling pathway in ceramide-induced hyperalgesia (2011) (29)
- Sphingosine-1-phosphate metabolism: A structural perspective (2015) (28)
- Sphingosine Kinase 1 Regulates Tumor Necrosis Factor-mediated RANTES Induction through p38 Mitogen-activated Protein Kinase but Independently of Nuclear Factor κB Activation* (2013) (28)
- Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death. (2016) (26)
- Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators. (2003) (26)
- Molecular mechanisms of regulation of sphingosine kinase 1. (2018) (26)
- Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization. (2015) (26)
- Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis. (2017) (25)
- Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates (2018) (25)
- An intrinsic lipid-binding interface controls sphingosine kinase 1 function[S] (2018) (25)
- Advances in determining signaling mechanisms of ceramide and role in disease (2019) (25)
- Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha ) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha. (2000) (23)
- Cloning and Characterization of a Mouse Endoplasmic Reticulum Alkaline Ceramidase AN ENZYME THAT PREFERENTIALLY REGULATES METABOLISM OF VERY LONG CHAIN CERAMIDES* (2003) (23)
- TNFα‐induced glutathione depletion lies downstream of cPLA2 in L929 cells (2001) (23)
- Activation of a retinoblastoma-protein-dependent pathway by sphingosine. (1995) (23)
- Bcl‐xL interrupts oxidative activation of neutral sphingomyelinase (2002) (22)
- Defining a Role for Acid Sphingomyelinase in the p38/Interleukin-6 Pathway* (2014) (22)
- GERIATRIC BIOSCIENCE: Signal Transduction in Cellular Senescence (1997) (22)
- Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation. (2011) (21)
- A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis (2018) (21)
- Distinct Roles for Hematopoietic and Extra-Hematopoietic Sphingosine Kinase-1 in Inflammatory Bowel Disease (2014) (21)
- Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5[S] (2018) (20)
- AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells (2018) (20)
- Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis (2017) (19)
- Activation of p38 Mitogen-Activated Protein Kinase in Gaucher’s Disease (2015) (19)
- Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function (2016) (19)
- Sphingolipids in vascular biology. (2002) (19)
- Decreased ceramide underlies mitochondrial dysfunction in Charcot‐Marie‐Tooth 2F (2017) (19)
- Sphingosine Kinase 1 Is Up-regulated during Hypoxia in U87MG Glioma Cells ROLE OF HYPOXIA-INDUCIBLE FACTORS 1 AND 2 * (2020) (18)
- Multiple actions of doxorubicin on the sphingolipid network revealed by flux analysis[S] (2018) (18)
- Advances in determining signaling mechanisms of ceramide and role in disease. (2019) (18)
- Effect of sphingosine kinase 1 inhibition on blood pressure (2013) (18)
- Bioactive Sphingolipids in Cancer Biology and Therapy (2015) (17)
- Loss of acid ceramidase in myeloid cells suppresses intestinal neutrophil recruitment (2017) (17)
- Ceramide: A Novel Second Messenger and Lipid Mediator (1996) (16)
- Ceramide and sphingosine-1-phosphate in cancer, two faces of the sphinx (2015) (16)
- A role for caspase‐2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells – implications for the CHK1‐suppressed pathway (2017) (16)
- A novel role for DGATs in cancer. (2019) (15)
- GRASP55 regulates intra‐Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis (2021) (15)
- Ceramide and the regulation of apoptosis and the stress response. (1996) (15)
- Functions of neutral ceramidase in the Golgi apparatus (2018) (15)
- Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells (2017) (14)
- Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation (2017) (14)
- Ceramide kinase regulates TNF-α-induced immune responses in human monocytic cells (2021) (14)
- Ceramide launches an acute anti‐adhesion pro‐migration cell signaling program in response to chemotherapy (2020) (14)
- Yeast sphingosine-1-phosphate phosphatases: assay, expression, deletion, purification, and cellular localization by GFP tagging. (2000) (14)
- Quantification of 3-ketodihydrosphingosine using HPLC-ESI-MS/MS to study SPT activity in yeast Saccharomyces cerevisiae[S] (2017) (13)
- Author Correction: Sphingolipids and their metabolism in physiology and disease (2018) (12)
- Cell density-dependent reduction of dihydroceramide desaturase activity in neuroblastoma cells[S] (2012) (12)
- Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry[S] (2018) (11)
- Use of yeast as a model system for studies of sphingolipid metabolism and signaling. (2000) (10)
- Cell-cycle-dependent changes in ceramide levels preceding retinoblastoma protein dephosphorylation in G 2 / M (1998) (10)
- Signal transduction in cellular senescence. (1997) (10)
- CHK1 regulates NF-κB signaling upon DNA damage in p53- deficient cells and associated tumor-derived microvesicles (2016) (10)
- PKCα is required for Akt-mTORC1 activation in Non-Small Cell Lung Carcinoma (NSCLC) with EGFR mutation (2019) (9)
- Oxidized graphene nanoparticles as a delivery system for the pro-apoptotic sphingolipid C6 ceramide. (2018) (9)
- Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway[S] (2018) (9)
- A Disrupted Homologue of the Human CLN3 or Juvenile Neuronal Ceroid Lipofuscinosis Gene in Saccharomyces cerevisiae: A Model to Study Batten Disease (1999) (9)
- Quantifying 1-deoxydihydroceramides and 1-deoxyceramides in mouse nervous system tissue. (2019) (9)
- Molecular Characterization of Rice OsLCB2a1 Gene and Functional Analysis of its Role in Insect Resistance (2016) (9)
- Transcriptional Regulation of Sphingosine Kinase 1 (2020) (8)
- Acid β-Glucosidase 1 Counteracts p38δ-dependent Induction of Interleukin-6 (2009) (8)
- Sustained PKCβII activity confers oncogenic properties in a phospholipase D‐ and mTOR‐dependent manner (2014) (8)
- Impact of sphingosine kinase on inflammatory pathways in fibroblast-like synoviocytes. (2011) (7)
- Neutral ceramidase deficiency protects against cisplatin-induced acute kidney injury (2022) (7)
- A Role of Sphingosine Kinase 1 in head & neck carcinogenesis (2010) (7)
- Defects in Cell Growth Regulation by C 18 : 0-Ceramide and Longevity Assurance Gene 1 ( LAG 1 ) in Human Head and Neck Squamous Cell Carcinomas ( HNSCC ) # (2004) (7)
- 1-Deoxysphinganine initiates adaptive responses to serine and glycine starvation in cancer cells via proteolysis of sphingosine kinase (2021) (6)
- Sphingosine kinase 1 downregulation is required for adaptation to serine deprivation (2021) (6)
- TNFalpha-induced glutathione depletion lies downstream of cPLA(2) in L929 cells. (2001) (6)
- Probing compartment-specific sphingolipids with targeted bacterial sphingomyelinases and ceramidases[S] (2019) (5)
- Delivery of long chain C16 and C24 ceramide in HeLa cells using oxidized graphene nanoribbons. (2020) (5)
- Ceramide, Ceramidase, and FasL Gene Therapy in Prostate Cancer (2005) (4)
- Insulin Regulates Protein Kinase CβII Expression through Enhanced Exon Inclusion in L6 Skeletal Muscle Cells (1998) (4)
- Regulated compartmentalization of enzymes in Golgi by GRASP55 controls cellular glycosphingolipid profile and function (2020) (4)
- TNF INDUCES THE LOSS OF SPHINGOSINE KINASE-1 BY A CATHEPSIN B DEPENDENT MECHANISM (2005) (4)
- The Role of Ceramide in Cell Regulation (2010) (4)
- Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides (2021) (4)
- Peripheral ß-glucocerebrosidase enzyme activity and lipidomics in ß-glucocerebrosidase (GBA1) mutation Parkinson disease (P2.149) (2015) (4)
- Potent Anti-Tumor Activity of a Novel Cationic Pyridinium-Ceramide Alone or In Combination with Gemcitabine Against Human Head and Neck Squamous Cell Carcinomas In vitro and In vivo (2006) (4)
- Dihydroceramide-based response to hypoxia. (2012) (4)
- Highly Efficient and Regioselective Phosphorylation of Sphingolipids by Phase-Trans fer Catalysis (2007) (3)
- Sphingosine Kinase 1 ( SK 1 ) Is Recruited to Nascent Phagosomes in Human Macrophages : Inhibition of SK 1 Translocation by Mycobacterium tuberculosis 1 (2005) (3)
- Ceramidases: Regulators of Turnover of Ceramide and Ceramide-Mediated Responses (2002) (3)
- Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations. (2016) (3)
- phosphate and ceramide-1-phosphate (2005) (2)
- Ceramide, Aging and Cellular Senescence (1997) (2)
- Immunoprecipitation of human telomerase reverse transcriptase with telomerase activity. (2001) (2)
- The doxorubicin‐induced cell motility network is under the control of the ceramide‐activated protein phosphatase 1 alpha (2021) (2)
- Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain (2018) (2)
- Yeast Sphingolipid Phospholipase Gene ISC1 Regulates the Spindle Checkpoint by a CDC55-Dependent Mechanism (2020) (2)
- Cloning and Characterization of the Major Promoter of the Human Protein Kinase C 6 Gene (1992) (1)
- Metabolism and Function of Sphingolipids in Saccharomyces Cerevisiae: Relevance to Cancer Research (2007) (1)
- Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer (2021) (1)
- Highly Efficient and Regioselective Phosphorylation of Sphingolipids by Phase‐Transfer Catalysis. (2008) (1)
- Tumor Necrosis Factor-a ( TNF-0 ) Signal Transduction through Ceramide (2001) (1)
- Yeast sphingolipid metabolism: clues and (2004) (1)
- Interaction of Ceramide Synthase with Long Chain Fatty Acyl‐CoA Synthase 5 Channels de novo Ceramide to Acylceramide Generation by Diacylglycerol Acyltransferase 2 on Lipid Droplets (2015) (1)
- Colon Cancer: The Role of Sphingolipid Metabolic Enzymes (2015) (1)
- Apoptosis: Ceramide and Lipid Mediators in Apoptosis (2011) (1)
- Correction: PKCα is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation (2019) (1)
- Maternal and fetal alkaline ceramidase 2 is required for placental vascular integrity in mice (2020) (1)
- phosphatase 2A Bcr-Abl1 stability and drug resistance by modulation of protein Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate (2011) (1)
- Dual Site Mechanism Governs Sphingosine Kinase 1 Membrane Binding and Biological Function (2017) (0)
- Resistance a la fumonosine (1998) (0)
- Peripheral Sphingolipids as Potential Biomarkers of Parkinson disease Including Sex-Related Differences (P3-11.007) (2023) (0)
- 676. A Role for Ceramide in AdGFPFasLTET Gene Therapy|[ast]| (2004) (0)
- Sphingolipids in the Pathogenesis of Head and Neck and Lung Cancers: Translational Aspects for Therapy and Biomarker Development (2015) (0)
- Sphingosine-1-Phosphate Receptor 3 (S1PR3) Promotes Myeloid Commitment of Human Hematopoietic and Leukemic Stem Cells (2018) (0)
- Author Correction: Sphingolipids and their metabolism in physiology and disease (2018) (0)
- Regulation of ERM cytoskeletal proteins by sphingolipids (2011) (0)
- Alkaline ceramidase catalyzes the hydrolysis of ceramides via a catalytic mechanism shared by Zn2+-dependent amidases (2018) (0)
- Microsoft Word-ACER2_overexpression_sensitizes_apoptosis-finaledit[1]-JBC-revised-1 (2010) (0)
- Absence of sphingosine kinase 1 alters progression of TNF-alpha induced arthritis (99.25) (2009) (0)
- Dysregulation of mitochondrial sphingolipid metabolism after traumatic brain injury (2012) (0)
- Abstract B80: Role for sphingosine kinase 1 in colon carcinogenesis (2010) (0)
- Upregulation of sphingosine kinase 1 in response to doxorubicin generates an angiogenic response via stabilization of Snail (2023) (0)
- Crystal structure and activation mechanism of human neutral sphingomyelinase 2 (2017) (0)
- ACSL1 Is a Key Regulator of Inflammatory and Macrophage Foaming Induced by Short-Term Palmitate Exposure or Acute High-Fat Feeding (2022) (0)
- Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides (2021) (0)
- Long‐Chain Glycosphingolipids Mediate Renal Aging (2011) (0)
- C6‐pyridinium ceramide induces Bax translocation from cytosol to mitochondria in MCF‐7 cells via a new signaling pathway (2006) (0)
- Ceramide Inactivates Cellular Protein Kinase C (cid:97) * (1996) (0)
- Abstract 5656: Role for Sphingosine kinase 1 in head & neck cancer (2010) (0)
- Erratum: Multiple actions of doxorubicin on the sphingolipid network revealed by flux analysis. (2021) (0)
- Yeast sphingolipid metabolism : clues and connections 1 , 2 (2004) (0)
- Sphingolipid signaling in the regulation of vascular network assembly (2007) (0)
- Crystal structure of human neutral ceramidase with Zn-bound phosphate (2015) (0)
- Developmentally regulated ceramide synthase 6 promotes apoptosis in oligodendrocytes (2011) (0)
- Short-Term Palmitate Exposure or Acute High Fat Feeding Promotes a Foamy and Inflammatory Macrophage Phenotype Which Involves ACSL1-Associated Signaling via the CD36/FABP4/P38/PPARδ Axis (2022) (0)
- Cell Density Dependent Inhibition of Dihydroceramide Desaturase (2011) (0)
- The Role of Ceramide in the Cellular Stress Response (1996) (0)
- CrmA inhibits TNFa-induced apoptosis by a mechanism upstream and distinct from Bcl-2 (1996) (0)
- Alkaline ceramidase 2 (ACER2) promotes tumor angiogenesis and growth via sphingosine‐1‐phosphate (2011) (0)
- Inhibition of chemotherapy‐induced neuropathic pain with S1P receptor modulators (2013) (0)
- Sphingosine Kinase 1 is regulated by PPARα in response to free fatty acids and mediates skeletal muscle IL‐6 production and signaling in diet‐induced obesity (2013) (0)
- Novel Mechanisms of Regulation of Bioactive Sphingolipids in Cancer Biology (2017) (0)
- A Milk-Fat Based Diet Increases Metastasis in the MMTV-PyMT Mouse Model of Breast Cancer (2021) (0)
- Mitochondrially targeted ceramide preferentially promotes autophagy , retards cell growth , and induces apoptosis (2010) (0)
- Neutral ceramidase acts in concert with thioesterase to produce ceramide in mitochondria (2011) (0)
- PKCα Mediates mTORC1 Activation in Non‐Small Cell Lung Carcinoma Cells with EGFR Deletion Mutation (2019) (0)
- Abstract B095: Tackling chemotherapy resistance of cancer cells: Inhibition of diacylglycerol O-acyltransferase 2 increases ceramide and cancer cell apoptosis (2020) (0)
- and Their Regulation by Nitric Oxide Biological Roles of Acid and Neutral Sphingomyelinases (2015) (0)
- Bioactive sphingolipids in inflammation and cancer (2010) (0)
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