Linda Birnbaum

Q: What Schools Are Affiliated With Linda Birnbaum

Linda Birnbaum is affiliated with the following schools: University of Cincinnati, Karlstad University, University of Illinois Urbana-Champaign, University of North Carolina at Chapel Hill, Duke University, University of Texas Southwestern Medical Center, University of Rochester, Tulane University

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According to Wikipedia, Linda Silber Birnbaum is an American toxicologist, microbiologist and the former director of the National Institute for Environmental Health Sciences, as well as the National Toxicology Program, positions she held from January 18, 2009 until October 3, 2019. She also serves as an adjunct professor at the University of North Carolina at Chapel Hill School of Public Health and as a member of the editorial board of Environment International.

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Linda Birnbaum's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds. (2006) (3169)
Brominated flame retardants: cause for concern? (2003) (1569)
Cytochrome P450 (1993) (1119)
In vivo effects of bisphenol A in laboratory rodent studies. (2007) (1110)
Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure. (2007) (705)
Dioxins: an overview. (2006) (521)
Polybrominated diphenyl ethers (PBDEs) in U.S. mothers' milk. (2003) (508)
Cancer and developmental exposure to endocrine disruptors. (2002) (474)
Polybrominated Diphenyl Ether (PBDE) Levels in an Expanded Market Basket Survey of U.S. Food and Estimated PBDE Dietary Intake by Age and Sex (2006) (362)
A novel abbreviation standard for organobromine, organochlorine and organophosphorus flame retardants and some characteristics of the chemicals. (2012) (353)
Characterization of potential endocrine-related health effects at low-dose levels of exposure to PCBs. (1999) (340)
The mechanism of dioxin toxicity: relationship to risk assessment. (1994) (339)
Prevalence and sociodemographic correlates of antinuclear antibodies in the United States. (2012) (331)
An Overview of the Effects of Dioxins and Dioxin-Like Compounds on Vertebrates, as Documented in Human and Ecological Epidemiology (2009) (304)
Non-carcinogenic effects of TCDD in animals (2000) (298)
Evaluation of the Association between Persistent Organic Pollutants (POPs) and Diabetes in Epidemiological Studies: A National Toxicology Program Workshop Review (2013) (295)
Developmental Origins of Health and Disease: Integrating Environmental Influences. (2015) (289)
Exposure to TCDD during development permanently alters reproductive function in male Long Evans rats and hamsters: reduced ejaculated and epididymal sperm numbers and sex accessory gland weights in offspring with normal androgenic status. (1995) (283)
Functional aspects of developmental toxicity of polyhalogenated aromatic hydrocarbons in experimental animals and human infants. (1995) (281)
Perfluorinated Compounds, Polychlorinated Biphenyls, and Organochlorine Pesticide Contamination in Composite Food Samples from Dallas, Texas, USA (2010) (266)
E-Waste and Harm to Vulnerable Populations: A Growing Global Problem (2015) (260)
Toxicological Function of Adipose Tissue: Focus on Persistent Organic Pollutants (2012) (258)
Phthalate Concentrations and Dietary Exposure from Food Purchased in New York State (2013) (255)
Monitoring Indoor Exposure to Organophosphate Flame Retardants: Hand Wipes and House Dust (2014) (247)
Health effects of polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs). (2003) (238)
Bisphenol A (BPA) in U.S. food. (2010) (234)
Polybrominated diphenyl ethers contamination of United States food. (2004) (231)
Pharmacokinetics of bisphenol A in humans following a single oral administration. (2015) (220)
A critical review of the developmental toxicity and teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: recent advances toward understanding the mechanism. (1990) (220)
Arsenic and Environmental Health: State of the Science and Future Research Opportunities (2015) (214)
A Research Strategy to Discover the Environmental Causes of Autism and Neurodevelopmental Disabilities (2012) (209)
Organophosphate Ester Flame Retardants: Are They a Regrettable Substitution for Polybrominated Diphenyl Ethers? (2019) (202)
Effects of perinatal PBDE exposure on hepatic phase I, phase II, phase III, and deiodinase 1 gene expression involved in thyroid hormone metabolism in male rat pups. (2009) (196)
Comparisons of estimated human body burdens of dioxinlike chemicals and TCDD body burdens in experimentally exposed animals. (1995) (194)
Developmental expression of two members of a new class of transcription factors: I. Expression of aryl hydrocarbon receptor in the C57BL/6N mouse embryo (1995) (191)
Endocrine effects of prenatal exposure to PCBs, dioxins, and other xenobiotics: implications for policy and future research. (1994) (189)
Water chlorination: essential process or cancer hazard? (1995) (187)
Possible mechanisms of thyroid hormone disruption in mice by BDE 47, a major polybrominated diphenyl ether congener. (2008) (186)
Polybrominated dibenzo-p-dioxins, dibenzofurans, and biphenyls: inclusion in the toxicity equivalency factor concept for dioxin-like compounds. (2013) (178)
Scientific Basis for Managing PFAS as a Chemical Class. (2020) (174)
Developmental exposure to a commercial PBDE mixture, DE-71: neurobehavioral, hormonal, and reproductive effects. (2010) (172)
Persistent abnormalities in the rat mammary gland following gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). (2002) (170)
Minireview: Endocrine Disruptors: Past Lessons and Future Directions. (2016) (169)
Polybrominated Diphenyl Ethers (PBDEs) and Hexabromocyclodecane (HBCD) in Composite U.S. Food Samples (2009) (162)
Disposition and excretion of 2,3,7,8-tetrachlorodibenzofuran in the rat. (1980) (160)
Bisphenol A, Bisphenol S, and 4-Hydroxyphenyl 4-Isoprooxyphenylsulfone (BPSIP) in Urine and Blood of Cashiers (2015) (156)
Use of toxic equivalency factors for risk assessment for dioxins and related compounds. (1995) (153)
Childhood obesity and environmental chemicals. (2011) (152)
Exposure assessment of adult intake of bisphenol A (BPA) with emphasis on canned food dietary exposures. (2015) (143)
Development of a refined database of mammalian relative potency estimates for dioxin-like compounds. (2006) (142)
Proceedings from the Third National Institutes of Health International Congress on Advances in Uterine Leiomyoma Research: comprehensive review, conference summary and future recommendations. (2014) (142)
Early-life prevention of non-communicable diseases (2013) (138)
Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial (2018) (136)
Dioxins and Cardiovascular Disease Mortality (2008) (135)
Role of CYP1A2 in hepatic sequestration of dioxin: studies using CYP1A2 knock-out mice. (1997) (135)
Toxicokinetics of BDE 47 in female mice: effect of dose, route of exposure, and time. (2004) (134)
Developmental effects of dioxins. (1995) (132)
Toxic interaction of specific polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin: increased incidence of cleft palate in mice. (1985) (130)
The COVID-19 pandemic and global environmental change: Emerging research needs (2020) (129)
Modeling receptor-mediated processes with dioxin: implications for pharmacokinetics and risk assessment. (1993) (129)
Elevated PBDE levels in pet cats: sentinels for humans? (2007) (129)
Developmental effects of dioxins and related endocrine disrupting chemicals. (1995) (128)
Unraveling the Health Effects of Environmental Mixtures: An NIEHS Priority (2013) (126)
Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on influenza virus host resistance in mice. (1996) (125)
Promotion of endometriosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats and mice: time-dose dependence and species comparison. (1996) (125)
Toxicokinetics of polybrominated diphenyl ether congeners 47, 99, 100, and 153 in mice. (2006) (125)
Polybrominated Diphenyl Ethers: A Case Study for Using Biomonitoring Data to Address Risk Assessment Questions (2006) (125)
Effect of exposure concentration, exposure rate, and route of administration on metabolism of benzene by F344 rats and B6C3F1 mice. (1989) (120)
Dioxins and endometriosis: a plausible hypothesis. (2001) (119)
Effect of dose on the absorption and excretion of [14C]benzene administered orally or by inhalation in rats and mice. (1987) (117)
TCDD alters medial epithelial cell differentiation during palatogenesis. (1989) (116)
Toxicokinetics of the flame retardant hexabromocyclododecane gamma: effect of dose, timing, route, repeated exposure, and metabolism. (2010) (116)
TCDD-induced altered expression of growth factors may have a role in producing cleft palate and enhancing the incidence of clefts after coadministration of retinoic acid and TCDD. (1990) (115)
Oxidative stress in female B6C3F1 mice following acute and subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). (2000) (113)
Consultation on assessment of the health risk of dioxins; re-evaluation of the tolerable daily intake (TDI): executive summary. (2000) (111)
The role of structure in the disposition of halogenated aromatic xenobiotics. (1985) (110)
A physiological model for simulation of benzene metabolism by rats and mice. (1989) (108)
Effects of CYP1A2 on disposition of 2,3,7, 8-tetrachlorodibenzo-p-dioxin, 2,3,4,7,8-pentachlorodibenzofuran, and 2,2',4,4',5,5'-hexachlorobiphenyl in CYP1A2 knockout and parental (C57BL/6N and 129/Sv) strains of mice. (1999) (108)
Environmental Chemicals: Evaluating Low-Dose Effects (2012) (107)
The effect of dose, dose rate, route of administration, and species on tissue and blood levels of benzene metabolites. (1989) (103)
Project TENDR: Targeting Environmental Neuro-Developmental Risks The TENDR Consensus Statement (2016) (101)
Gene‐environment interplay in common complex diseases: forging an integrative model—recommendations from an NIH workshop (2011) (99)
Comparative ability of various PCBs, PCDFs, and TCDD to induce cytochrome P450 1A1 and 1A2 activity following 4 weeks of treatment. (1993) (99)
Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (1994) (99)
Chemically activated luciferase gene expression (CALUX) cell bioassay analysis for the estimation of dioxin-like activity: critical parameters of the CALUX procedure that impact assay results. (2005) (98)
TCDD-induced hyperplasia of the ureteral epithelium produces hydronephrosis in murine fetuses. (1987) (98)
Differential effects of two lots of aroclor 1254: congener-specific analysis and neurochemical end points. (2001) (98)
Etiology of retinoic acid-induced cleft palate varies with the embryonic stage. (1989) (95)
Retinoic acid-induced alterations in the expression of growth factors in embryonic mouse palatal shelves. (1990) (94)
Distribution and excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin in congenic strains of mice which differ at the Ah locus. (1986) (94)
Toxicology of Dioxins and Related Chemicals (1994) (94)
Differences in the metabolism and disposition of inhaled [3H]benzene by F344/N rats and B6C3F1 mice. (1988) (92)
Dose-response relationships for disposition and hepatic sequestration of polyhalogenated dibenzo-p-dioxins, dibenzofurans, and biphenyls following subchronic treatment in mice. (1998) (89)
Regional hepatic CYP1A1 and CYP1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin evaluated with a multicompartment geometric model of hepatic zonation. (1997) (88)
The GuLF STUDY: A Prospective Study of Persons Involved in the Deepwater Horizon Oil Spill Response and Clean-Up (2017) (88)
Acute administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in pregnant Long Evans rats: association of measured tissue concentrations with developmental effects. (2000) (87)
Polybrominated diphenyl ether (PBDE) effects in rat neuronal cultures: 14C-PBDE accumulation, biological effects, and structure-activity relationships. (2005) (87)
Species differences in the disposition of inhaled butadiene. (1986) (85)
Female Sprague-Dawley rats exposed to a single oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin exhibit sustained depletion of aryl hydrocarbon receptor protein in liver, spleen, thymus, and lung. (1998) (85)
Retinoic acid and 2,3,7,8-tetrachlorodibenzo-p-dioxin selectively enhance teratogenesis in C57BL/6N mice. (1989) (84)
Comparative absorption and bioaccumulation of polybrominated diphenyl ethers following ingestion via dust and oil in male rats. (2008) (84)
Interactive regulation of Ah and glucocorticoid receptors in the synergistic induction of cleft palate by 2,3,7,8-tetrachlorodibenzo-p-dioxin and hydrocortisone. (1994) (83)
Integrated Human and Ecological Risk Assessment: A Case Study of Persistent Organic Pollutants (POPs) in Humans and Wildlife (2003) (82)
Re Human and Mammalian Toxic Equivalency Factors for Dioxins and Dioxin-Like Compounds: The Who 2005 Re-Evaluation (2006) (80)
Dose-response relationships of tissue distribution and induction of CYP1A1 and CYP1A2 enzymatic activities following acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice. (1995) (80)
Consortium-Based Science: The NIEHS’s Multipronged, Collaborative Approach to Assessing the Health Effects of Bisphenol A (2012) (80)
Mimicking of Estradiol Binding by Flame Retardants and Their Metabolites: A Crystallographic Analysis (2013) (80)
Induction of oxidative stress in brain tissues of mice after subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. (1998) (78)
IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans (2015) (78)
Muconic acid determinations in urine as a biological exposure index for workers occupationally exposed to benzene. (1991) (77)
The Next Generation of Risk Assessment Multi-Year Study—Highlights of Findings, Applications to Risk Assessment, and Future Directions (2016) (75)
Dose–Response Relationships for Polyhalogenated Dioxins and Dibenzofurans Following Subchronic Treatment in Mice (1997) (75)
Meeting Report: Moving Upstream—Evaluating Adverse Upstream End Points for Improved Risk Assessment and Decision-Making (2008) (74)
Structure-induction versus structure-toxicity relationships for polychlorinated biphenyls and related aromatic hydrocarbons. (1985) (74)
Induction of hepatic mixed function oxidases in senescent rodents (1978) (74)
Dose-response relationships in mice following subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: CYP1A1, CYP1A2, estrogen receptor, and protein tyrosine phosphorylation. (1994) (74)
Teratogenic potency of TCDD, TCDF and TCDD-TCDF combinations in C57BL/6N mice. (1985) (74)
Promotion of endometriosis in mice by polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls. (1997) (73)
Physiological model for the pharmacokinetics of 2,3,7,8-tetrachlorodibenzofuran in several species. (1983) (72)
The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the hepatic estrogen and glucocorticoid receptors in congenic strains of Ah responsive and Ah nonresponsive C57BL/6J mice. (1991) (72)
Disposition of polychlorinated dibenzo-p-dioxins, dibenzofurans, and non-ortho polychlorinated biphenyls in pregnant long evans rats and the transfer to offspring. (2001) (71)
Use of a Physiologically Based Pharmacokinetic Model for Rats to Study the Influence of Body Fat Mass and Induction of CYP1A2 on the Pharmacokinetics of TCDD (2006) (70)
When environmental chemicals act like uncontrolled medicine (2013) (70)
Urinary Tetrabromobenzoic Acid (TBBA) as a Biomarker of Exposure to the Flame Retardant Mixture Firemaster® 550 (2014) (70)
State of the Science of Endocrine Disruptors (2013) (70)
Teratogenic effects of 2,3,7,8-tetrabromodibenzo-p-dioxin and three polybrominated dibenzofurans in C57BL/6N mice. (1991) (69)
Comparison of the Use of a Physiologically Based Pharmacokinetic Model and a Classical Pharmacokinetic Model for Dioxin Exposure Assessments (2005) (68)
Disposition of three glycol ethers administered in drinking water to male F344/N rats. (1990) (68)
Partitioning of polybrominated diphenyl ethers (PBDEs) in serum and milk from the same mothers. (2010) (68)
Determination of parameters responsible for pharmacokinetic behavior of TCDD in female Sprague-Dawley rats. (1997) (68)
TCDD exposure of human embryonic palatal shelves in organ culture alters the differentiation of medial epithelial cells. (1991) (67)
Daily cycle of bHLH-PAS proteins, Ah receptor and Arnt, in multiple tissues of female Sprague-Dawley rats. (1998) (67)
Polyfluoroalkyl Compounds in Texas Children from Birth through 12 Years of Age (2011) (67)
Disposition of octachlorodibenzo-p-dioxin (OCDD) in male rats. (1988) (66)
Comparison of Metal Levels between Postmortem Brain and Ventricular Fluid in Alzheimer's Disease and Nondemented Elderly Controls. (2016) (66)
PBDE flame retardants, thyroid disease, and menopausal status in U.S. women (2016) (64)
A physiologically based pharmacokinetic model for 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD) in the rat: tissue distribution and CYP1A induction. (1993) (63)
Effects of TCDD on embryonic ureteric epithelial EGF receptor expression and cell proliferation. (1990) (62)
Effect of prenatal exposure to TCDD on the promotion of endometriotic lesion growth by TCDD in adult female rats and mice. (1999) (62)
Differential Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J Mice Congenic at the Ah Locus (1990) (61)
PCBs Are a Health Risk for Humans and Wildlife (2000) (61)
Teratogenic effects of polychlorinated dibenzofurans in combination in mice (1987) (60)
Molecular Biology of Aging: Gene Stability and Gene Expression (1985) (59)
Hexabromocyclododecane (HBCD) Stereoisomers in U.S. Food from Dallas, Texas (2012) (58)
Polybrominated diphenyl ether levels in foodstuffs collected from three locations from the United States. (2010) (58)
The Exposome: Embracing the Complexity for Discovery in Environmental Health (2016) (58)
Disposition of 2,3,7,8-tetrabromodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat: biliary excretion and induction of cytochromes CYP1A1 and CYP1A2. (1991) (57)
Dioxin-like effects observed in male rats following exposure to octachlorodibenzo-p-dioxin (OCDD) during a 13-week study. (1988) (56)
Differential time-course and dose-response relationships of TCDD-induced CYP1B1, CYP1A1, and CYP1A2 proteins in rats. (1997) (56)
A Mixture of Dioxins, Furans, and Non-ortho PCBs Based upon Consensus Toxic Equivalency Factors Produces Dioxin-Like Reproductive Effects (2003) (56)
Subchronic/chronic toxicity of a mixture of four chlorinated dibenzo-p-dioxins in rats. II. Biochemical effects. (1998) (56)
Influence of the Ah locus on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the hepatic epidermal growth factor receptor. (1991) (56)
Cellular alterations and enhanced induction of cleft palate after coadministration of retinoic acid and TCDD. (1989) (55)
2,3,7,8-Tetrachlorodibenzo-p-dioxin alters embryonic palatal medial epithelial cell differentiation in vitro. (1989) (54)
Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research (2015) (54)
Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes. (2014) (53)
Comparisons of the effects of TCDD and hydrocortisone on growth factor expression provide insight into their interaction in the embryonic mouse palate. (1992) (53)
Disposition of BDE 47 in developing mice. (2006) (53)
Distribution and excretion of 2,3,7,8-tetrachlorodibenzofuran in C57BL/6J and DBA/2J mice. (1981) (53)
Cross-sectional Associations between Exposure to Persistent Organic Pollutants and Leukocyte Telomere Length among U.S. Adults in NHANES, 2001–2002 (2015) (53)
Uptake and excretion of [14C]methyl bromide as influenced by exposure concentration. (1985) (53)
Pharmacokinetic basis of age-related changes in sensitivity to toxicants. (1991) (52)
Subchronic/chronic toxicity of a mixture of four chlorinated dibenzo-p-dioxins in rats. I. Design, general observations, hematology,and liver concentrations. (1998) (52)
Physiologically based pharmacokinetic model for developmental exposures to TCDD in the rat. (2004) (52)
A multicompartment geometric model of the liver in relation to regional induction of cytochrome P450s. (1997) (51)
Disposition and kinetics of tetrabromobisphenol A in female Wistar Han rats (2014) (50)
Relative potencies of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls derived from hepatic porphyrin accumulation in mice. (1996) (50)
Altered hepatic drug metabolism in senescent mice (1980) (50)
Tissue disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in maternal and developing long-evans rats following subchronic exposure. (2000) (50)
Limited PCB antagonism of TCDD-induced malformations in mice. (1992) (50)
Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) disposition following pulmonary, oral, dermal, and parenteral exposures to rats. (1996) (50)
Novel and distinct metabolites identified following a single oral dose of α- or γ-hexabromocyclododecane in mice. (2012) (49)
Senescent changes in rodent hepatic epoxide metabolism. (1979) (48)
Teratogenicity of three polychlorinated dibenzofurans in C57BL/6N mice. (1987) (48)
Dioxins: model chemicals for assessing receptor-mediated toxicity. (1995) (48)
2,3,7,8-Tetrachlorodibenzofuran tissue distribution and excretion in guinea pigs (1981) (48)
Tissue distribution of polybrominated diphenyl ethers in male rats and implications for biomonitoring. (2008) (48)
Relative toxicity and tumor-promoting ability of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,4,7,8-pentachlorodibenzofuran (PCDF), and 1,2,3,4,7,8-hexachlorodibenzofuran (HCDF) in hairless mice. (1990) (48)
Improving and Expanding Estimates of the Global Burden of Disease Due to Environmental Health Risk Factors (2019) (47)
Assessment of polybrominated diphenyl ether exposures and health risks associated with consumption of southern Mississippi catfish. (2008) (47)
Catfish consumption as a contributor to elevated PCB levels in a non-Hispanic black subpopulation. (2008) (47)
Dose-response relationships for induction of CYP1A1 and CYP1A2 enzyme activity in liver, lung, and skin in female mice following subchronic exposure to polychlorinated biphenyls. (2000) (47)
Workshop on perinatal exposure to dioxin-like compounds. V. Immunologic effects. (1995) (45)
Distribution and excretion of 2,3,6,2',3',6'- and 2,4,5,2',4',5'-hexachlorobiphenyl in senescent rats. (1983) (45)
Toxicokinetics of the flame retardant hexabromocyclododecane alpha: effect of dose, timing, route, repeated exposure, and metabolism. (2011) (45)
Differences in the pathways for metabolism of benzene in rats and mice simulated by a physiological model. (1989) (44)
Synergistic interaction of 2,3,7,8,-tetrachlorodibenzo-p-dioxin and hydrocortisone in the induction of cleft palate in mice. (1986) (44)
Approaches for assessing risks to sensitive populations: lessons learned from evaluating risks in the pediatric population. (2010) (44)
Differential effects of two lots of aroclor 1254 on enzyme induction, thyroid hormones, and oxidative stress. (2001) (43)
Assessment of host resistance to Trichinella spiralis in mice following preinfection exposure to 2,3,7,8-TCDD. (1994) (43)
Evidence for the role of the Ah receptor in response to dioxin. (1994) (43)
Flame Retardants in Furniture Foam: Benefits and Risks (2011) (43)
Subchronic Exposure of [3H]- 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in female B6C3F1 mice: relationship of steady-state levels to disposition and metabolism. (2001) (43)
Exposure assessment for endocrine disruptors: some considerations in the design of studies. (2003) (42)
Metabolism of citral, an alpha,beta-unsaturated aldehyde, in male F344 rats. (1990) (41)
A physiologically based pharmacokinetic model for developmental exposure to BDE-47 in rats. (2010) (41)
Dose-dependent localization of TCDD in isolated centrilobular and periportal hepatocytes. (1999) (41)
Toxicokinetics of inhaled 1,3-butadiene in monkeys: comparison to toxicokinetics in rats and mice. (1991) (40)
Hydronephrosis in mice exposed to TCDD-contaminated breast milk: identification of the peak period of sensitivity and assessment of potential recovery. (1991) (40)
Brominated and Chlorinated Flame Retardants: The San Antonio Statement (2010) (40)
Inhibition of human and rat CYP1A2 by TCDD and dioxin-like chemicals. (2005) (40)
Maternal Dioxin Exposure Combined with a Diet High in Fat Increases Mammary Cancer Incidence in Mice (2009) (40)
Dose-response relationships for polyhalogenated dioxins and dibenzofurans following subchronic treatment in mice. I. CYP1A1 and CYP1A2 enzyme activity in liver, lung, and skin. (1997) (40)
Inhibition of 2-fluorenamine-induced mutagenesis in Salmonella typhimurium by vitamin A. (1979) (39)
Differential toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J mice congenic at the Ah Locus. (1990) (39)
Age-related changes in glucuronidation and deglucuronidation in liver, small intestine, lung, and kidney of male Fischer rats. (1985) (39)
The importance of pharmacokinetics in determining the relative potency of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzofuran. (1995) (39)
Metabolism of [14C]benzene by cynomolgus monkeys and chimpanzees. (1992) (39)
Research Opportunities for Cancer Associated with Indoor Air Pollution from Solid-Fuel Combustion (2012) (39)
Accumulation of M1dG DNA adducts after chronic exposure to PCBs, but not from acute exposure to polychlorinated aromatic hydrocarbons. (2008) (38)
Agent Orange exposure, Vietnam War veterans, and the risk of prostate cancer (2008) (38)
Disposition of citral in male Fischer rats. (1988) (38)
A pharmacodynamic analysis of TCDD-induced cytochrome P450 gene expression in multiple tissues: dose- and time-dependent effects. (1998) (38)
Opposite effects of 2,2',4,4',5,5'-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on the antibody response to sheep erythrocytes in mice. (1997) (37)
Naturally complex: Perspectives and challenges associated with Botanical Dietary Supplement Safety assessment. (2018) (37)
Induction of hepatic mixed function oxidases in senescent rodents—II. Effect of polychlorinated biphenyls (1978) (37)
Characterization of the Peak Period of Sensitivity for the Induction of Hydronephrosis in C57BL/6N Mice following Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1990) (37)
Extrapolation of a PBPK model for dioxins across dosage regimen, gender, strain, and species. (2000) (36)
Alternatives to PFASs: Perspectives on the Science (2015) (36)
Comparative dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin and three polychlorinated dibenzofurans. (1989) (36)
The Importance of Pharmacokinetics in Determining the Relative Potency of 2,3,7,8-Tetrachlorodibenzo-p-dioxin and 2,3,7,8-Tetrachlorodibenzofuran (1995) (36)
In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters postnatal development of seminal vesicle epithelium. (2000) (36)
Characterization of the peak period of sensitivity for the induction of hydronephrosis in C57BL/6N mice following exposure to 2,3,7, 8-tetrachlorodibenzo-p-dioxin. (1990) (35)
Age-related changes in dermal absorption of 2,3,7, 8-tetrachlorodibenzo-p-dioxin and 2,3,4,7,8-pentachlorodibenzofuran. (1990) (34)
Fate of 2,3,7,8-tetrachlorodibenzofuran in the monkey. (1981) (34)
Dietary exposure to PCBs and dioxins in children. (1999) (34)
Subcellular localization of TCDD differs between the liver, lungs, and kidneys after acute and subchronic exposure: species/dose comparisons and possible mechanism. (1996) (34)
TEFs: A Practical Approach to a Real-World Problem (1999) (33)
2,3,7,8-Tetrachlorodibenzo-p-dioxin in pregnant Long Evans rats: disposition to maternal and embryo/fetal tissues. (1998) (33)
Rat embryonic palatal shelves respond to TCDD in organ culture. (1990) (33)
Uppsala Consensus Statement on Environmental Contaminants and the Global Obesity Epidemic (2016) (33)
Predictors of serum dioxin, furan, and PCB concentrations among women from Chapaevsk, Russia. (2010) (33)
Advancing the Next Generation of Health Risk Assessment (2012) (33)
Effect of dose on the disposition of methoxyethanol, ethoxyethanol, and butoxyethanol administered dermally to male F344/N rats. (1992) (32)
Toxicity equivalency factors for PCBs? (1991) (32)
The effect of dose on 2,3,7,8-TCDD tissue distribution, metabolism and elimination in CYP1A2 (-/-) knockout and C57BL/6N parental strains of mice. (2009) (32)
Intersection of Systematic Review Methodology with the NIH Reproducibility Initiative (2014) (32)
Impact of repeated exposure on the toxicokinetics of BDE 47 in mice. (2006) (32)
Screening for Developmental Neurotoxicity at the National Toxicology Program: The Future Is Here. (2019) (32)
Human Health Effects of Brominated Flame Retardants (2011) (31)
Integrated Human and Ecological Risk Assessment: A Case Study of Tributyltin and Triphenyltin Compounds (2003) (31)
Lack of correlation between sensitivity to growth inhibition and receptor number for transforming growth factor beta in human squamous carcinoma cell lines. (1989) (31)
Exposure to Asbestos-Containing Vermiculite Ore and Respiratory Symptoms among Individuals Who Were Children While the Mine Was Active in Libby, Montana (2010) (31)
NADPH-driven lipid peroxidation in rat liver nuclei and nuclear membranes. (1980) (31)
Toxicity and disposition of 2,3,4,7,8-pentachlorodibenzofuran (4PeCDF) in the rhesus monkey (Macaca mulatta). (1988) (30)
Implementing Systematic Review at the National Toxicology Program: Status and Next Steps (2013) (30)
Timing of Environmental Exposures as a Critical Element in Breast Cancer Risk. (2015) (30)
Evaluation of the persistence of hydronephrosis induced in mice following in utero and/or lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. (1991) (29)
Interactive effects between 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,2',4,4',5,5'-hexachlorobiphenyl in female B6C3F1 mice: tissue distribution and tissue-specific enzyme induction. (1996) (29)
Benzene hemoglobin adducts in mice and rats: characterization of formation and physiological modeling. (1990) (29)
Increased production of mutagenic metabolites of carcinogens by tissues from senescent rodents. (1979) (29)
Species differences in the metabolism and disposition of inhaled 1,3-butadiene and isoprene. (1990) (29)
Disposition of [14C]methyl bromide in rats after inhalation. (1985) (29)
Developmental toxicity of perfluorodecanoic acid in C57BL/6N mice. (1989) (28)
The True Cost of PFAS and the Benefits of Acting Now (2021) (28)
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and 2,3,7,8-tetrachlorodibenzofuran (TCDF) in pregnant C57BL/6N mice: distribution to the embryo and excretion (1985) (28)
Management of medulloepithelioma of the ciliary body with brachytherapy. (2002) (27)
DISINFECTION BY-PRODUCTS IN DRINKING WATER : CRITICAL ISSUES IN HEALTH EFFECTS RESEARCH (1997) (27)
Processes involved in retinoic acid production of small embryonic palatal shelves and limb defects. (1990) (27)
NIEHS's New Strategic Plan (2012) (27)
From endocrine disruptors to nanomaterials: advancing our understanding of environmental health to protect public health. (2011) (27)
The fate of isoprene inhaled by rats: comparison to butadiene. (1987) (27)
Environmental exposures, breast development and cancer risk: Through the looking glass of breast cancer prevention. (2015) (27)
Inhibition of high-density growth arrest in human squamous carcinoma cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). (1990) (27)
Disruption of estrogen homeostasis as a mechanism for uterine toxicity in Wistar Han rats treated with tetrabromobisphenol A. (2016) (27)
Relative Sensitivities of 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Cyp1a-1 and Cyp1a-2 Gene Expression and Immunotoxicity in Female B6C3F1 Mice (1994) (27)
Rapid distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to embryonic tissues in C57BL/6N mice and correlation with palatal uptake in vitro. (1996) (27)
Laser Doppler measurements of cutaneous blood flow in ageing mice and rats. (1991) (26)
Changes in hepatic microsomal membrane fluidity with age (1982) (26)
Disposition of 1,2,3,7,8-pentachlorodibenzofuran in the rat. (1988) (26)
Dioxin and Polychlorinated Biphenyl Concentrations in Mother's Serum and the Timing of Pubertal Onset in Sons (2011) (25)
Differences in tissue distribution of HBCD alpha and gamma between adult and developing mice. (2011) (25)
Basic science: Bedrock of progress. (2016) (25)
Subchronic/chronic toxicity of 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (HpCDD) in rats. Part I. Design, general observations, hematology, and liver concentrations. (1997) (25)
Effect of repeated benzene inhalation exposures on benzene metabolism, binding to hemoglobin, and induction of micronuclei. (1990) (25)
Mouse strains for chemical carcinogenicity studies: overview of a workshop. (1988) (25)
Relationship between CYP1A enzyme activities and protein levels in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. (1996) (25)
TBBPA disposition and kinetics in pregnant and nursing Wistar Han IGS rats. (2018) (24)
Methoxyresorufin: an inappropriate substrate for CYP1A2 in the mouse. (1998) (24)
A COMPARISON AND DISCUSSION OF TWO DIFFERING METHODS OF MEASURING DIOXIN-LIKE COMPOUNDS: GAS CHROMATOGRAPHY-MASS SPECTROMETRY AND THE CALUX BIOASSAY - IMPLICATIONS FOR HEALTH STUDIES (1999) (24)
A toxikinetic model for simulation of benzene metabolism. (1989) (24)
TCDD alters the extracellular matrix and basal lamina of the fetal mouse kidney. (1987) (24)
2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated oxidative stress in CYP1A2 knockout (CYP1A2-/-) mice. (1999) (24)
Associations Between Selected Xenobiotics and Antinuclear Antibodies in the National Health and Nutrition Examination Survey, 1999–2004 (2015) (24)
Characterization of hemoglobin adduct formation in mice and rats after administration of [14C]butadiene or [14C]isoprene. (1989) (23)
Species differences in the distribution of inhaled butadiene in tissues. (1987) (23)
Absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) after low dose dermal exposure. (1991) (23)
Chemical Mixtures and Combined Chemical and Nonchemical Stressors (2018) (23)
Effect of dose, time, and pretreatment on the biliary excretion and tissue distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. (1993) (23)
Serum Metabolomic Profiles in Neonatal Mice following Oral Brominated Flame Retardant Exposures to Hexabromocyclododecane (HBCD) Alpha, Gamma, and Commercial Mixture (2016) (23)
Reproductive and Hormonal Risk Factors for Antinuclear Antibodies (ANA) in a Representative Sample of U.S. Women (2014) (23)
Dietary Fat Alters Body Composition, Mammary Development, and Cytochrome P450 Induction after Maternal TCDD Exposure in DBA/2J Mice with Low-Responsive Aryl Hydrocarbon Receptors (2009) (23)
Senescence-associated decline in hepatic peroxisomal enzyme activities corresponds with diminished levels of retinoid X receptor alpha, but not peroxisome proliferator-activated receptor alpha (2002) (23)
Subchronic/chronic toxicity of 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (HpCDD) in rats. Part II. Biochemical effects. (1997) (23)
Synthetic Chemicals and Cardiometabolic Health Across the Life Course Among Vulnerable Populations: a Review of the Literature from 2018 to 2019 (2020) (23)
Decreased ligand binding to the hepatic glucocorticoid and epidermal growth factor receptors after 2,3,4,7,8-pentachlorodibenzofuran and 1,2,3,4,7,8-hexachlorodibenzofuran treatment of pregnant mice. (1989) (22)
Acute toxicity of perfluorodecanoic acid in C57BL/6 mice differs from 2,3,7,8-tetrachlorodibenzo-p-dioxin. (1989) (22)
Effects of thyroid hormones on the induction of cleft palate by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL6N mice (1986) (22)
Effects of age, sex, and pharmacologic agents on the biliary elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in F344 rats. (1998) (22)
Age-related changes in the metabolism and excretion of allyl isothiocyanate. A model compound for glutathione conjugation. (1986) (22)
The Effect of Pretreatment on the Biliary Excretion of 2,3,7,8-Tetrachlorodibenzo-p-dioxin, 2,3,7,8-Tetrachlorodibenzofuran, and 3,3′,4,4′-Tetrachlorobiphenyl in the Rat (1993) (21)
Serum polychlorinated biphenyls and leukocyte telomere length in a highly-exposed population: The Anniston Community Health Survey. (2017) (21)
Disposition and excretion of intravenous 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD) in rats. (1991) (21)
Temporal trends in serum concentrations of polychlorinated dioxins, furans, and PCBs among adult women living in Chapaevsk, Russia: a longitudinal study from 2000 to 2009 (2011) (21)
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) distribution and cytochrome P4501A induction in young adult and senescent male mice. (1995) (21)
PERSISTENT ORGANIC POLLUTANTS: AN OVERVIEW (2012) (21)
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) disrupts early morphogenetic events that form the lower reproductive tract in female rat fetuses. (2002) (21)
Pharmacokinetics of bisphenol A in humans following dermal administration (2020) (21)
Disposition of the emerging brominated flame retardant, bis(2-ethylhexyl) tetrabromophthalate, in female Sprague Dawley rats: effects of dose, route and repeated administration (2017) (21)
Enhanced potential for oxidative stress in livers of senescent rats by the peroxisome proliferator-activated receptor alpha agonist perfluorooctanoic acid (2004) (21)
Contamination of U.S. Butter with Polybrominated Diphenyl Ethers from Wrapping Paper (2010) (20)
Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian boys. (2014) (20)
Informing 21st-Century Risk Assessments with 21st-Century Science (2016) (20)
Effects of dose and routes of exposure on the disposition of 2,3,7,8-[3H]tetrabromodibenzo-p-dioxin (TBDD) in the rat. (1993) (20)
S-Phenylcysteine formation in hemoglobin as a biological exposure index to benzene (2005) (20)
Localization of a portion of the ribosomal RNA genes in Escherichia coli. (1971) (20)
Estimation of tetrabromobisphenol A (TBBPA) percutaneous uptake in humans using the parallelogram method. (2015) (20)
The National Toxicology Program Web-based Nonneoplastic Lesion Atlas (2014) (20)
Regulating toxic chemicals for public and environmental health (2017) (19)
The NIH Common Fund/Roadmap Epigenomics Program: Successes of a comprehensive consortium (2019) (19)
Tetrabromobisphenol A (TBBPA) Alters ABC Transport at the Blood-Brain Barrier. (2019) (19)
Mercury toxicity in children. (2013) (19)
Estimation of Octanol-Water Partition Coefficients and Correlation with Dermal Absorption for Several Polyhalogenated Aromatic Hydrocarbons, (1993) (19)
Prepubertal Serum Concentrations of Organochlorine Pesticides and Age at Sexual Maturity in Russian Boys (2015) (18)
ONE Nano: NIEHS’s Strategic Initiative on the Health and Safety Effects of Engineered Nanomaterials (2013) (18)
Applying Research to Public Health Questions: Timing and the Environmentally Relevant Dose (2009) (18)
Age-related changes in the disposition of benzyl acetate. A model compound for glycine conjugation. (1989) (18)
Age‐Related Changes in Carcinogen Metabolism (1987) (18)
Hexabromonaphthalene contaminants of polybrominated biphenyls: chemical composition and disposition in the rat. (1983) (18)
Mouse breast cancer model-dependent changes in metabolic syndrome-associated phenotypes caused by maternal dioxin exposure and dietary fat. (2009) (18)
Estimation of octanol-water partition coefficients and correlation with dermal absorption for several polyhalogenated aromatic hydrocarbons. (1993) (18)
Maturational changes in dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in Fischer 344 rats. (1993) (18)
Estimation of human percutaneous bioavailability for two novel brominated flame retardants, 2-ethylhexyl 2,3,4,5-tetrabromobenzoate (EH-TBB) and bis(2-ethylhexyl) tetrabromophthalate (BEH-TEBP). (2016) (18)
Disposition and excretion of 2,3,4,7,8-pentachlorodibenzofuran in the rat. (1987) (18)
Levels of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in southern Mississippi catfish and estimation of potential health risks. (2009) (18)
Beyond Cholinesterase Inhibition: Developmental Neurotoxicity of Organophosphate Ester Flame Retardants and Plasticizers (2021) (17)
Developmental toxicity of 1,1,1-trichloroethane in CD rats. (1989) (17)
Applying Research to Public Health Questions: Biologically Relevant Exposures (2010) (17)
Relative potency based on hepatic enzyme induction predicts immunosuppressive effects of a mixture of PCDDS/PCDFS and PCBS. (2008) (17)
Biomonitoring of Metals, Polybrominated Diphenyl Ethers, Polychlorinated Biphenyls, and Persistent Pesticides in Vietnamese Female Electronic Waste Recyclers (2017) (17)
Induction of ethoxyresorufin-O-deethylase and inhibition of glucocorticoid receptor binding in skin and liver of haired and hairless HRS/J mice by topically applied 2,3,7,8-tetrachlorodibenzo-p-dioxin. (1990) (16)
Age-independent, gray matter-localized, brain-enhanced oxidative stress in male fischer 344 rats: brain levels of F(2)-isoprostanes and F(4)-neuroprostanes. (2003) (16)
Developmental Toxicity of Perfluorodecanoic Acid in C57BL/6N Mice (1989) (16)
Metabolism of 1,3-butadiene by lung and liver microsomes of rats and mice repeatedly exposed by inhalation to 1,3-butadiene. (1988) (16)
Benzene dosimetry in experimental animals: relevance for risk assessment. (1992) (16)
Predictors of Serum Chlorinated Pesticide Concentrations among Prepubertal Russian Boys (2013) (16)
Prenatal Programming and Toxicity (PPTOX) Introduction. (2015) (16)
The fate of β-hexabromocyclododecane in female C57BL/6 mice. (2013) (15)
The human exposome and health in the Anthropocene (2020) (15)
The biochemical toxicity of perfluorodecanoic acid in the mouse is different from that of 2,3,7,8-tetrachlorodibenzo-p-dioxin. (1989) (15)
Effect of exposure concentration on the disposition of inhaled butoxyethanol by F344 rats. (1992) (15)
Unrecognized or Potential Risk Factors for Childhood Cancer (2005) (15)
Anniston community health survey: Follow-up and dioxin analyses (ACHS-II)—methods (2016) (15)
The effect of pretreatment on the biliary excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 3,3',4,4'-tetrachlorobiphenyl in the rat. (1993) (15)
Renal cytochrome P-450's-electrophoretic and electron paramagnetic resonance studies. (1979) (14)
Gene expression changes in immune response pathways following oral administration of tetrabromobisphenol A (TBBPA) in female Wistar Han rats. (2017) (14)
5th International PCB Workshop--summary and implications. (2010) (14)
Presence of a high-molecular-weight form of catalse in enzyme purified from mouse liver. (1977) (14)
Comparative acute nephrotoxicity of salicylic acid, 2,3-dihydroxybenzoic acid, and 2,5-dihydroxybenzoic acid in young and middle aged Fischer 344 rats. (1991) (14)
Phthalates in our food (2013) (14)
Human Health Effects of Bisphenol A (2014) (14)
Out of the frying pan and out of the fire: the indispensable role of exposure science in avoiding risks from replacement chemicals (2010) (14)
Allylisopropylacetamide preferentially interacts with the phenobarbital-inducible form of rat hepatic microsomal P-450. (1976) (14)
The acute toxicity of 2,3,4,7,8-pentachlorodibenzofuran (4PeCDF) in the male Fischer rat (1988) (13)
Teratogenic effects of polychlorinated dibenzofurans in combination in C57BL/6N mice. (1987) (13)
15 Years Out: Reinventing ICCVAM (2013) (13)
Teratologic Evaluation of Hexabrominated Naphthalenes in C57BL/6N Mice (1986) (13)
Uptake of vinylidene fluoride in rats simulated by a physiological model. (1988) (13)
Sex-Specific Behavioral Effects Following Developmental Exposure to Tetrabromobisphenol A (TBBPA) in Wistar Rats. (2019) (12)
CYP1A2 is not required for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunosuppression. (2004) (12)
The Office of Health Assessment and Translation: A Problem-Solving Resource for the National Toxicology Program (2011) (12)
Designing Safer Chemicals (2013) (12)
Relationship between serum trimethylamine N‐oxide and exposure to dioxin‐like pollutants (2018) (12)
Effect of o-benzyl-p-chlorophenol on drug-metabolizing enzymes in rats. (1986) (12)
A single gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin disrupts the adult uterine response to estradiol in mice. (2013) (12)
Teratologic evaluation of hexabrominated naphthalenes in C57BL/6N mice. (1986) (12)
Physiologically based modeling of 2-butoxyethanol disposition in rats following different routes of exposure. (1993) (12)
The biological fate of decabromodiphenyl ethane following oral, dermal or intravenous administration (2017) (12)
The fate of inhaled azodicarbonamide in rats. (1987) (12)
Disinfection by-products in drinking water: critical issues in health effects research. (1997) (12)
Preparing for disasters. (2015) (12)
EPA's reassessment of dioxin risk: Directed health research (1993) (12)
The influence of aging on intestinal absorption of TCDD in rats. (1987) (12)
Disposition of [14C]methyl bromide in Fischer-344 rats after oral or intraperitoneal administration. (1984) (12)
Age-related changes in mutagen activation by rat tissues. (1982) (12)
Toxicology of Dioxins and Dioxinlike Compounds (2005) (11)
Evolution in Environmental Health: Incorporating the Infectious Disease Paradigm (2010) (11)
Age-related changes in toxicity and biotransformation of potassium cyanide in male C57BL6N mice (1990) (11)
Relative potency for altered humoral immunity induced by polybrominated and polychlorinated dioxins/furans in female B6C3F1/N mice. (2014) (11)
Age-related changes in benzene disposition in male C57BL/6N mice described by a physiologically based pharmacokinetic model. (1994) (11)
Safety Testing: Moving Toward Alternative Methods (2010) (11)
Toxicity and distribution of 2,3,7,8-tetrachlorodibenzofuran in male guinea pigs. (1983) (11)
Relative sensitivities of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced Cyp1a-1 and Cyp1a-2 gene expression and immunotoxicity in female B6C3F1 mice. (1994) (11)
Disposition of 4,4'-thiobis(6-t-butyl-m-cresol) in rats. (1983) (11)
Dioxin and the AH Receptor: Synergy of Discovery. (2017) (10)
2,4,6-Tribromophenol Exposure Decreases P-glycoprotein Transport at the Blood-Brain Barrier. (2019) (10)
Subchronic effects of exposure to octachlorodibenzodioxin (OCDD) (1989) (10)
Exposure of dioxin-like chemicals in participants of the Anniston community health survey follow-up. (2018) (10)
Effect of age on the in vitro percutaneous absorption of phenols in mice. (1994) (10)
Disposition and metabolism of 2,3-[14C]dichloropropene in rats after inhalation. (1985) (10)
Effect of repeated benzene inhalation exposures on subsequent metabolism of benzene. (1989) (9)
The effects of TCDD on receptors for epidermal growth factor, glucocorticoid, and estrogen in Ah-responsive and -nonresponsive congenic mice and the effects of TCDD on estradiol metabolism in a liver tumor promotion model in female rats. (1990) (9)
Polychlorinated biphenyl exposure and DNA methylation in the Anniston Community Health Survey (2019) (9)
2,4,6-Tribromophenol Disposition and Kinetics in Rodents: Effects of Dose, Route, Sex, and Species. (2019) (9)
A brief survey of butadiene health effects: a role for metabolic differences. (1993) (9)
A mixture of polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and non-ortho polychlorinated biphenyls (PCBs) changed the lipid content of pregnant Long Evans rats. (2002) (9)
Effect of vapor concentration on the disposition of inhaled 2,3-dichloropropene in Fischer-344 rats. (1985) (9)
Hypertension in Relation to Dioxins and Polychlorinated Biphenyls from the Anniston Community Health Survey Follow-Up (2019) (9)
Disposition of [14C]2,3-dichloropropene in Fischer-344 rats after oral or intraperitoneal administration. (1984) (9)
Effect of four‐week repeated inhalation exposure to unconjugated azodicarbonamide on specific and non‐specific airway sensitivity of the guinea pig (1989) (9)
Disposition of inhaled isoprene in B6C3F1 mice. (1991) (8)
TSCA Reform Under Way in Congress (2010) (8)
FutureTox IV Workshop Summary: Predictive Toxicology for Healthy Children. (2021) (8)
Proposed mechanistic description of dose-dependent BDE-47 urinary elimination in mice using a physiologically based pharmacokinetic model. (2013) (8)
Predictors of blood volatile organic compound levels in Gulf coast residents (2017) (8)
The effect of age on the glucuronidation and toxicity of 4,4'-thiobis(6-t-butyl-m-cresol). (1988) (8)
Environmental justice: a continuing commitment to an evolving concept. (2009) (8)
Health Risk Characterization of Dioxins and Related Compounds (2005) (8)
Working Together: Research- and Science-Based Regulation of BPA (2013) (8)
Measuring Partnership Activities: Partnerships in Environmental Public Health Evaluation Metrics Manual (2012) (7)
Effects of age and dose on disposition and metabolism of salicylic acid in male Fischer 344 rats. (1990) (7)
Health effects of dioxins : People are animals, and vice-versa! (2000) (7)
Genetic Modification of the Association between Peripubertal Dioxin Exposure and Pubertal Onset in a Cohort of Russian Boys (2012) (7)
Prechronic toxicity of o-benzyl-p-chlorophenol in rats and mice. (1986) (7)
Effect of inhaled azodicarbonamide on F344N rats and B6C3F1 mice with 2-week and 13-week inhalation exposures☆ (1990) (7)
Effect of GenX on P-Glycoprotein, Breast Cancer Resistance Protein, and Multidrug Resistance–Associated Protein 2 at the Blood–Brain Barrier (2020) (7)
Metabolism of inhaled butadiene to monkeys: comparison to rodents. (1989) (7)
Intestinal absorption of two glucose analogues in rats of different ages (1987) (7)
DISPOSITION OF 2,3,7,8-TETRACHLORODIBENZOFURAN IN GUINEA PIGS, RATS, AND MONKEYS (1982) (7)
Disposition of the Emerging Brominated Flame Retardant, 2-Ethylhexyl 2,3,4,5-Tetrabromobenzoate, in Female SD Rats and Male B6C3F1 Mice: Effects of Dose, Route, and Repeated Administration. (2016) (7)
Developmental Toxicity of 2,3,4,7,8-Pentachlorodibenzofuran in the Fischer 344 Flat (1989) (7)
Effects of dose and route of exposure on dioxin disposition (1992) (7)
Role of Transforming Growth Factor β in the Proliferative Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Human Squamous Carcinoma Cells (1990) (7)
Usepa's risk characterization of dioxin and related compounds (2000) (7)
A persistent hexabromonaphthalene isomer is 2,3,4,5,6,7-hexabromonaphthalene. (1985) (6)
A Preliminary Approach to Characterizing Variability and Uncetainty in the Mammalian PCDD/F and PCB TEFs (2004) (6)
Dioxins: Health Effects⋆ (2011) (6)
Age-related changes in disposition and metabolism of benzene in male C57BL/6N mice. (1991) (6)
Bisphenols: More unnecessary surprises (2016) (6)
How Many Urine Samples Are Needed to Accurately Assess Exposure to Non-Persistent Chemicals? The Biomarker Reliability Assessment Tool (BRAT) for Scientists, Research Sponsors, and Risk Managers (2020) (6)
Acute inhalation exposure of azodicarbonamide in the guinea pig. (1987) (6)
The effect of environmental chemicals on human health. (2008) (6)
Developmental toxicity of 2,3,4,7,8-pentachlorodibenzofuran in the Fischer 344 rat. (1989) (6)
The acute toxicity of 2,3,4,7,8-pentachlorodibenzofuran (4PeCDF) in the male Fischer rat. (1988) (5)
The Influence of Obesity on the Pharmacokinetics of Dioxin in Mice: An Assessment Using Classical and PBPK Modeling (2018) (5)
Presumptive Contamination: A New Approach to PFAS Contamination Based on Likely Sources (2022) (5)
In vitro synthesis of Escherichia coli ribosomal RNA. (1973) (5)
Effect of Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Polychlorinated Biphenyls (PCBs) on Mitochondrial DNA (mtDNA) Copy Number in Rats. (2021) (5)
The influence of chemical impurity on estimating relative potency factors for PCBs (2003) (5)
Development of a Refined Database of Relative Potency Estimates to Facilitate Better Characterization of Variability and Uncertainty in the Current Mammalian TEFs for PCDDs, PCDFs, and Dioxin-like PCBs (2004) (5)
Changes in Cytochrome P450 in Senescence (1993) (5)
Disposition of o-benzyl-p-chlorophenol in male rats. (1986) (5)
Circulating MicroRNAs, Polychlorinated Biphenyls, and Environmental Liver Disease in the Anniston Community Health Survey. (2022) (5)
Effects of thyroid hormones on the induction of cleft palate by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6N mice. (1986) (5)
Congener specific measurement of polybrominated diphenyl ethers in 47 individual milk samples from nursing mothers in the U.S.A. (2003) (4)
Adverse Health Outcomes Caused By Dioxin‐Activated AHR in Humans (2011) (4)
Location of the ribosomal RNA cistron of Escherichia coli: A second site (2004) (4)
NIEHS: Making a Mark on Translational Research Science (2018) (4)
Mechanisms of TCDD-induction of cleft palate: insights from invivo and invitro approaches (1992) (4)
Leading the World’s Premier Environmental Health Organization: A Message from Linda Birnbaum (2009) (4)
Response to “Comment on Scientific Basis for Managing PFAS as a Chemical Class” (2021) (4)
Chemical characterization and disposition studies with 1,2,7,8-tetrabromodibenzofuran in the rat. (1994) (4)
Shaping Our Legacy : Reproductive Health and the Environment Program on Reproductive Health and the Environment (2008) (4)
Serum concentrations of legacy and emerging per- and polyfluoroalkyl substances in the Anniston Community Health Surveys (ACHS I and ACHS II) (2021) (4)
Dermal disposition of Tetrabromobisphenol A Bis(2,3-dibromopropyl) ether (TBBPA-BDBPE) using rat and human skin. (2019) (4)
Age-related changes in glucose metabolizing enzymes in spleen, thymus, and pulmonary lavage cells from F344 rats (1984) (4)
Measurement of steady-state blood concentrations in B6C3F1 mice exposed by inhalation to vinylidene fluoride. (1990) (4)
Dioxin-like compound exposures and DNA methylation in the Anniston Community Health Survey Phase II. (2020) (3)
An Examination of Child and Adolescent Neurodevelopment Through National Institutes of Health Studies (2020) (3)
Metabolism and pharmacokinetics of 1,3-butadiene (1996) (3)
Age-Related Changes in Sensitivity to Environmental Chemicals (1990) (3)
Pregnenolone-16alpha-carbonitrile-inducible cytochrome P450 in rat liver. (1976) (3)
2,4,6-Tribromophenol disposition and kinetics in pregnant and nursing Sprague Dawley rats. (2020) (3)
PBDE Contamination of U . S . Food and Human Milk ; and PBDE , PCDD / F , PCB , and Levels in U . S . Human Blood ( 1973 and 2003 ) (2004) (3)
Tackling the Research Challenges of Health and Climate Change (2009) (3)
Updating the NIEHS Strategic Plan (2017) (3)
Research integrity: a government perspective. (1999) (3)
Indoor and outdoor air PBDE levels in a Southwestern US city (2010) (3)
Disposition of inhaled 1-chloro-2-propanol in F344/N rats. (1988) (3)
A PBPK model describing the pharmacokinetics of γ-HBCD exposure in mice. (2021) (3)
NIEHS Supports Partnerships in Environmental Public Health (2009) (3)
My Winding Road: From Microbiology to Toxicology and Environmental Health. (2016) (3)
The perceived cultural self-efficacy of respiratory therapists and nurses: A comparative study (2010) (3)
Telomeres as targets for the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs) in rats. (2020) (3)
Age-related changes in toxicity and biotransformation of potassium cyanide in male C57BL/6N mice. (1990) (3)
Toxicological research involving humans: ethical and regulatory considerations. (2005) (2)
Receptor-mediated toxicity and implications for risk assessment. (1994) (2)
Application of a Relative Potency Factor Approach in the Assessment of Health Risks Associated with Exposures to Mixtures of Dioxin-Like Compounds (2010) (2)
Editorial Independence for EHP (2009) (2)
A Repeat Call for the Banning of Asbestos (2010) (2)
Factors Affecting the Disposition and Persistence of Halogenated Furans and Dioxins (1983) (2)
Moving NIEHS Forward for the Next Five Years (2018) (2)
Adverse effects of TCDD on mammary gland development in long evans rats : A two generational study (2000) (2)
Environmental Health Science for Regulatory Decisionmaking (2011) (2)
Fluoride exposure and cognitive neurodevelopment: Systematic review and dose-response meta-analysis. (2023) (2)
Chemical Effects on Breast Development, Function, and Cancer Risk: Existing Knowledge and New Opportunities (2022) (2)
Disposition of benzo(f)quinoline in male rats. (1985) (2)
2,3,7,8-Tetrachlorodibenzofuran tissue distribution and excretion in guinea pig. (1981) (2)
Phthalates Should Be Regulated as a Class to Protect the Brains of Our Children. (2021) (2)
Toxic Equivalency Factors for Dioxins and Dioxin-like Compounds 2 3 (2006) (2)
Iii. Case Studies A. Persistent Organic Pollutants (pops) in Humans and Wildlife (2002) (2)
Protecting Our Children from Climate Change (2014) (2)
TEMPORAL CHANGES OF SERUM CONCENTRATIONS OF POLYCHLORINATED BIPHENYLS AND ORGANOCHLORINE PESTICIDES IN A RESIDENTIAL COHORT (2015) (1)
Biomonitoring of Polybrominated Dioxins & Furans, Polychlorinated Dioxins & Furans, and Dioxin Like Polychlorinated Biphenyls in Vietnamese Female Electronic Waste Recyclers (2022) (1)
Evaluation of Risk Trade-offs in Passenger Compartment Fire Retardant Usage - a Case Study (2009) (1)
Exposure, effects, and public health challenges (2014) (1)
Differential receptor tyrosine kinase phosphorylation in the uterus of rats following developmental exposure to tetrabromobisphenol A (2021) (1)
Bioavailability of Pbdes in Male Rats From Orally Administered Household Dust (2007) (1)
Role of developmental exposure to endocrine disruptors in cancer (2002) (1)
Is Supersize More than Just Too Much Food? (2012) (1)
Changing the Climate of Respiratory Clinical Practice. Insights from the 2016 Climate and Health Assessment of the U.S. Global Change Research Program. (2016) (1)
The Epidemiologic Silver Lining of Climate Change. (2017) (1)
Topographic Analysis of Posterior Corneal Surface Changes After LASIK (2002) (1)
Utilization of a PBPK model to predict the distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in humans during critical windows of development (2003) (1)
Mechanisms Involved in the Enhanced Susceptibility of Senescent Rats to the Hepatocarcinogenic Effect of Peroxisome Proliferators: Role of Peroxisome Proliferator-Activated Receptor alpha (PPAR), Cell Proliferation and Oxidative Stress (2001) (1)
Systems biology approach for better understanding of mechanisms of neurodevelopment toxicity: A case study using the major flame retardant HBCD (2012) (1)
Application of a physiologically based pharmacokinetic (PBPK) model to aid in understanding relative potency factors for dioxin-like chemicals (2003) (1)
Dermal absorption of the antioxidant 4,4'-thiobis(6-tert-butyl-m-cresol) in Sencar mice and Fischer rats. (1987) (1)
Advancing the science on chemical classes (2023) (1)
Letter to the editors regarding "The conundrum of the PFOA human half-life, an international collaboration." (2022) (1)
A science-based agenda for health-protective chemical assessments and decisions: overview and consensus statement (2023) (1)
Environmental Biodynamics (2021) (1)
Moving upstream : evaluating adverse upstream end points for improved risk assessment and decision-making (2020) (1)
RE: Cellular Telephone Use and the Risk of Brain Tumors: Update of the UK Million Women Study. (2022) (1)
Dioxins and Cardiovascular Mortality: A Review (2008) (1)
Marking a New Understanding of Climate and Health (2016) (1)
Role of transforming growth factor beta in the proliferative effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on human squamous carcinoma cells. (1990) (1)
Exposure Science Digests : Demonstrating How Exposure Science Protects Us From Chemical , Physical , and Biological Agents (2011) (1)
A new consensus on reconciling fire safety with environmental & health impacts of chemical flame retardants. (2023) (0)
GENETIC MODIFICATION OF THE ASSOCIATION BETWEEN DIOXIN EXPOSURE AND PUBERTAL ONSET IN A COHORT OF RUSSIAN BOYS (2011) (0)
Early life contributions to breast cancer risk (2016) (0)
Comment: Tackling toxicology and environmental health (2009) (0)
Role of Transforming Growth Factor ÃŸin the Proliferative Effect of 2,3,7,8-Tetrachlorodibenzo-/>-dioxin on Human Squamous Carcinoma Cells (2006) (0)
Crystal structure of human estrogen sulfotransferase (SULT1E1) in complex with inactive cofactor PAP and brominated flame retardant TBBPA (tetrabromobisphenol A) (2013) (0)
ICCVAM: Birnbaum and Stokes Respond (2010) (0)
Reply to Comments on ``Bisphenol A (BPA) in U.S. Food'' (2011) (0)
Tissue distribution and elimination of BDE 47 in mice following a single oral dose (2004) (0)
Using tissue dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as a predictive response for reversible biochemical changes (2002) (0)
Applied Epidemiology and Exposure Challenges in Response to the Gulf Oil Spill (2018) (0)
Comparing mixtures of dioxin-like and non dioxin-like PCBs to TCDD (2002) (0)
Agent orange in Vietnam and human effects : What should we look for? What might we expect? (2003) (0)
Differential effects of two lots of aroclor 1254R : Congener analysis and neurochemical endpoints (2000) (0)
Correlation between an automated functional assay that predicts targeted agent (TA) sensitivity and the tumor response of the sorafenib treatment evaluated within the MOST clinical trial. (2018) (0)
Localization, Enrichment, and in Vitro Transcription of the Ribosomal Rnagenes in Escherichia Coli (1972) (0)
Development of the NIH Disaster Research Response (DR2) Program and Ongoing Efforts in the U.S.A. (2018) (0)
Correction to The True Cost of PFAS and the Benefits of Acting Now (2021) (0)
Erratum: “Marking a New Understanding of Climate and Health” (2016) (0)
Hypertension, Cytokines, and Dioxin-Like Compounds in the Anniston Community Health Survey II (2018) (0)
Importance of Exposure and Health Disaster Research (2018) (0)
Human Health Effects of Biomass Incinerators Dioxins Damage Children and Adults (2012) (0)
CHDS: A National Treasure that Keeps on Giving. (2020) (0)
disposition and kinetics in pregnant and nursing Wistar Han rats (2017) (0)
Time-course transfer of PCDD/Fs and non-ortho PCBs to fetal and neonatal long evans rats (2000) (0)
Community Corner (2008) (0)
Environmental Exposures to PCDDs, PCDFs, and PCBs and Mechanism of Steatohepatitis in the Anniston Community Health Survey II (2018) (0)
Environmental Health (2020) (0)
Crystal structure of human estrogen sulfotransferase (SULT1E1) in complex with inactive cofactor PAP and estradiol (E2) (2013) (0)
Enhanced metabolism of 7-ethoxycoumarin in senescent rodents. Abstr. (1979) (0)
A NEW STANDARD OF ABBREVIATIONS FOR BROMINATED, CHLORINATED AND PHOSPHORUS CONTAINING FLAME RETARDANTS (2012) (0)
Health Implications of Environmental and Occupational Exposure to Organics and Metals in Northern Vietnamese Female Electronic Waste (E-waste) Recyclers (2016) (0)
In Memoriam: Jane Ellen Simmons (2022) (0)
278. Industrial Environmental, Health, and Safety Preplanning for Improved Operations and Product Quality (1999) (0)
Useof the Du Pont “ AutomaticClinicalAnalyzer ” in DirectDeterminationof LacticAcidin Plasma (2004) (0)
Wireless technologies, non-ionizing electromagnetic fields and children: Identifying and reducing health risks. (2023) (0)
Dioxin and dioxin-like chemicals inhibit CYP1A2 activity (2002) (0)
Long-term impacts of early life exposures (2016) (0)
Global Environmental Change and Our Health (2018) (0)
How Did I Ever Get Here? The 2018 Mildred S. Christian Award Winner (2018) (0)
SOT at 50: A Proud Legacy, A Vibrant Future (2011) (0)
NIEHS Celebrates 50 Years of Environmental Health Research at the NIH (2016) (0)
Identifying Cost Savings Associated with NIEHS-Funded Research (2018) (0)
Cancer and the environment: Filling knowledge gaps together (2010) (0)
Repeatability of the Orbscan II in a normal population (2001) (0)
Synthetic Chemicals and Cardiometabolic Health Across the Life Course Among Vulnerable Populations: a Review of the Literature from 2018 to 2019 (2020) (0)
Problems in evaluating the health impacts of radio frequency radiation. (2022) (0)
Conducting evaluations of evidence that are transparent, timely and can lead to health-protective actions (2022) (0)
What Limits Will the World Health Organization Recommend for PFOA and PFOS in Drinking Water? (2023) (0)
NIH/NIEHS Gulf Of Mexico Oil Spill Research: Overview and Future Research Needs (2014) (0)
Senescent changes in mouse hepatic aryl hydrocarbon hydroxylase. Abstr. (1979) (0)
CHILDHOOD OBESITY AND ENVIRONMENTAL CHEMCALS (2011) (0)
Characterization ofPotential Endocrine-Related Health Effects atLow-Dose Levels ofExposure toPCBs (1999) (0)
Subcommittee on Health Committee on Energy and Commerce United States House of Representatives Hearing on “Current Issues Related to Medical Liability Reform” Statement of James Hurley, ACAS, MAAA Medical Malpractice Subcommittee American Academy of Actuaries (2005) (0)
Re-evaluation of Dioxin. Presentation by Dr. Linda Birnbaum to the 102nd Meeting of the Great Lakes Water Quality Board, Chicago, Illinois, July 15, 1993 (1993) (0)
Response to “Commentary on ‘Elevated PCB levels in anglers and unsuspected transport of pollutants from aquatic food webs into human foods’”☆ (2008) (0)
Physiologically based pharmacokinetic modeling as a tool for predicting dose response relationship for TCDD during development (2002) (0)
Retirement of Hugh A. Tilson (2014) (0)
Effects of two lots of arolor 1254 on hepatic retinoid concentration in rats (2000) (0)
Measurements of PBDEs in Cat Serum and Cat Food : Is There a Relationship With Feline Hyperthyroidism ? (2006) (0)
Biomonitoring of Female Vietnamese Electronic Waste Recyclers for Selected Metals and Organics (2018) (0)
Chemical Obesogens and Obesity (2013) (0)
High-Molecular-Weight Form of Catalase in Enzyme Purified from Mouse Liver (2005) (0)
Expanded assessment of xenobiotic associations with antinuclear antibodies in the United States, 1988-2012. (2022) (0)
In Memoriam: Herbert L. Needleman (2017) (0)
Cross-Sectional Associations Between Exposure To Persistent Organic Pollutants And Leukocyte Telomere Length Among Us Adults: National Health And Nutrition Examination Survey, 2001-2002 (2015) (0)
Lack of Correlation between Sensitivity to Growth Inhibition and Receptor Number for Transforming Growth Factor ÃŸin Human Squamous Carcinoma Cell Lines (2006) (0)
A New Era at the NIEHS/NTP, with Linda Birnbaum (2009) (0)
Crystallographic Analysis and Mimicking of Estradiol Binding: Pedersen et al. Respond (2014) (0)
The need for continued research on dioxin and related compounds (2003) (0)
Crystal structure of human estrogen sulfotransferase (SULT1E1) in complex with inactive cofactor PAP and metabolite of brominated flame retardant 3OH BDE47 (3-hydroxyl bromodiphenyl ether) (2013) (0)
Respiratory Symptoms in Oil Spill Clean-Up Workers Participating in the Gulf STUDY (2014) (0)
Commemorating Toxicology at the National Institute of Environmental Health Sciences on the Occasion of Its 50th Anniversary (2016) (0)
Senescent alterations in hepatic epoxide metabolism in rodents. Abstr. (1978) (0)
Bioavailability and Biological Response of Pbdes Administered to Rats in Household Dust (2007) (0)
THE NEXUS OF BIOFUELS ENERGY, CLIMATE CHANGE, AND HEALTH (2013) (0)
ENDOCRINE‐DISRUPTING CHEMICALS (2020) (0)
Advances in Environmental Health and Disaster Research 15 Years After Hurricane Katrina. (2020) (0)
Utilization of physiologically based pharmacokinetic model (PBPK) to study the influence of body fat mass and induction of CYP1A2 on the pharmacokinetics of TCDD (2003) (0)
Panel 4: EPA and Emerging Science (2011) (0)
Journal of the American Aging Association (2002) (0)

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