Linda Hsieh-Wilson
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American chemist
Linda Hsieh-Wilson's AcademicInfluence.com Rankings
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Chemistry
Linda Hsieh-Wilson's Degrees
- PhD Chemistry Stanford University
Why Is Linda Hsieh-Wilson Influential?
(Suggest an Edit or Addition)According to Wikipedia, Linda Carol Hsieh-Wilson is an American chemist and the Milton and Rosalind Chang Professor of Chemistry at the California Institute of Technology. She is known for her work in chemical neurobiology on understanding the structure and function of carbohydrates in the nervous system. Her studies have revealed critical roles for carbohydrates and protein glycosylation in fundamental processes ranging from cellular metabolism to memory storage. She is a member of the American Academy of Arts and Sciences and was elected to the National Academy of Sciences in 2022.
Linda Hsieh-Wilson's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Sulfation patterns of glycosaminoglycans encode molecular recognition and activity (2006) (472)
- Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism (2012) (466)
- Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP–32 and spinophilin (1999) (297)
- Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics. (2007) (295)
- Exploring the O-GlcNAc proteome: direct identification of O-GlcNAc-modified proteins from the brain. (2004) (277)
- A chemoenzymatic approach toward the rapid and sensitive detection of O-GlcNAc posttranslational modifications. (2003) (238)
- Direct in-gel fluorescence detection and cellular imaging of O-GlcNAc-modified proteins. (2008) (207)
- Profiling the sulfation specificities of glycosaminoglycan interactions with growth factors and chemotactic proteins using microarrays. (2007) (179)
- Dynamic O-GlcNAc Modification Regulates CREB-Mediated Gene Expression and Memory Formation (2011) (166)
- Quantitation of O-Glycosylation Stoichiometry and Dynamics using Resolvable Mass Tags (2010) (148)
- Activation of the Transcriptional Function of the NF-κB Protein c-Rel by O-GlcNAc Glycosylation (2013) (143)
- A chondroitin sulfate small molecule that stimulates neuronal growth. (2004) (138)
- A sulfated carbohydrate epitope inhibits axon regeneration after injury (2012) (134)
- Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration (2016) (130)
- Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs) (2017) (129)
- Chemical approaches to understanding O-GlcNAc glycosylation in the brain. (2008) (126)
- The chemical neurobiology of carbohydrates. (2008) (126)
- Chemical approaches to deciphering the glycosaminoglycan code. (2005) (123)
- Semaphorin 3A Binds to the Perineuronal Nets via Chondroitin Sulfate Type E Motifs in Rodent Brains* (2013) (123)
- Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1. (1999) (120)
- Neuroactive chondroitin sulfate glycomimetics. (2008) (117)
- Dynamic glycosylation of the transcription factor CREB: a potential role in gene regulation. (2003) (113)
- A 'molecular switchboard'--covalent modifications to proteins and their impact on transcription. (2004) (113)
- Site-Specific GlcNAcylation of Human Erythrocyte Proteins (2009) (111)
- Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus α-synuclein and β-amyloid aggregates (2018) (110)
- Parallel identification of O-GlcNAc-modified proteins from cell lysates. (2004) (101)
- Discovery of a TNF-α Antagonist Using Chondroitin Sulfate Microarrays (2006) (99)
- Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches (2011) (97)
- Protein fucosylation regulates synapsin Ia/Ib expression and neuronal morphology in primary hippocampal neurons. (2006) (93)
- Phosphorylation of Spinophilin Modulates Its Interaction with Actin Filaments* (2003) (90)
- Tunable Heparan Sulfate Mimetics for Modulating Chemokine Activity (2013) (82)
- Chemoenzymatic Probes for Detecting and Imaging Fucose-α(1-2)-galactose Glycan Biomarkers (2012) (78)
- Protein phosphatase 1 regulation by inhibitors and targeting subunits (2001) (77)
- End-functionalized glycopolymers as mimetics of chondroitin sulfate proteoglycans. (2010) (76)
- Directing Neuronal Signaling through Cell-Surface Glycan Engineering (2014) (69)
- Sugar-dependent modulation of neuronal development, regeneration, and plasticity by chondroitin sulfate proteoglycans (2015) (69)
- Spinophilin is phosphorylated by Ca2+/calmodulin‐dependent protein kinase II resulting in regulation of its binding to F‐actin (2004) (61)
- Direct identification of nonreducing GlcNAc residues on N-glycans of glycoproteins using a novel chemoenzymatic method. (2007) (54)
- Long-lived engineering of glycans to direct stem cell fate. (2015) (48)
- Tailored glycopolymers as anticoagulant heparin mimetics. (2013) (48)
- A Role for Fucose α(1−2) Galactose Carbohydrates in Neuronal Growth (2005) (46)
- Glycan Engineering for Cell and Developmental Biology. (2016) (46)
- Activation of phospholipase C pathways by a synthetic chondroitin sulfate‐E tetrasaccharide promotes neurite outgrowth of dopaminergic neurons (2007) (45)
- Insights into antibody catalysis: structure of an oxygenation catalyst at 1.9-angstrom resolution. (1996) (45)
- The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines (2007) (39)
- An Isotope-Coded Photocleavable Probe for Quantitative Profiling of Protein O-GlcNAcylation. (2019) (37)
- Methods for the Detection, Study, and Dynamic Profiling of O-GlcNAc Glycosylation. (2018) (36)
- Long noncoding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransferase CHST15 (2019) (34)
- O-GlcNAcylation of core components of the translation initiation machinery regulates protein synthesis (2019) (32)
- Photoactivatable Glycopolymers for the Proteome-Wide Identification of Fucose-α(1-2)-Galactose Binding Proteins (2014) (31)
- Identification of the Plasticity-Relevant Fucose-α(1−2)-Galactose Proteome from the Mouse Olfactory Bulb† (2009) (31)
- Optimization of Chemoenzymatic Mass Tagging by Strain-Promoted Cycloaddition (SPAAC) for the Determination of O-GlcNAc Stoichiometry by Western Blotting. (2018) (29)
- Expedient Synthesis of Core Disaccharide Building Blocks from Natural Polysaccharides for Heparan Sulfate Oligosaccharide Assembly. (2019) (25)
- Comprehensive mapping of O-GlcNAc modification sites using a chemically cleavable tag. (2016) (24)
- Use of cerny epoxides for the accelerated synthesis of glycosaminoglycans. (2003) (23)
- Predicting glycosaminoglycan surface protein interactions and implications for studying axonal growth (2017) (23)
- Synthetic probes of glycosaminoglycan function. (2013) (23)
- Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation. (2017) (21)
- Discovery of a TNF-alpha antagonist using chondroitin sulfate microarrays. (2006) (21)
- Deciphering the Functions of O-GlcNAc Glycosylation in the Brain: The Role of Site-Specific Quantitative O-GlcNAcomics. (2018) (19)
- Antibody catalysis of peptidyl-prolyl cis-trans isomerization in the folding of RNase T1. (1998) (18)
- Murine Anti-vaccinia Virus D8 Antibodies Target Different Epitopes and Differ in Their Ability to Block D8 Binding to CS-E (2014) (17)
- A role for fucose alpha(1-2) galactose carbohydrates in neuronal growth. (2005) (14)
- Sulfated glycans engage the Ang/Tie pathway to regulate vascular development (2020) (13)
- Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves both DARPP‐32‐dependent and independent pathways (2005) (11)
- Microarray method for the rapid detection of glycosaminoglycan-protein interactions. (2012) (11)
- Structure–function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8 (2017) (11)
- Photoaffinity Probes for the Identification of Sequence-Specific Glycosaminoglycan-Binding Proteins. (2020) (11)
- The Chemical Neurobiology of Carbohydrates (2008) (11)
- Improving Biologic Drugs via Total Chemical Synthesis (2013) (10)
- Bioorganic chemistry: A sweet synthesis (2007) (9)
- Tools for mammalian glycoscience research (2022) (8)
- Visualization of O‐GlcNAc Glycosylation Stoichiometry and Dynamics Using Resolvable Poly(ethylene glycol) Mass Tags (2013) (7)
- Control of protein phosphatase I in the dendrite. (1999) (6)
- PFK 1 Glycosylation Is a Key Regulator of Cancer Cell Growth and Central Metabolic Pathways (2013) (6)
- The Tangled Web: Unraveling the Molecular Basis for Communications in the Brain (2001) (6)
- Long-Lived Glycan Engineering to Direct Stem Cell Fate * * (2015) (3)
- Expedient Synthesis of Core Disaccharide Building Blocks from Natural Polysaccharides for Heparan Sulfate Oligosaccharide Assembly (2019) (2)
- Insights into antibody catalysis : Structure of an oxygenation catalyst at 1 . 9A resolution ( crystal structure / catalytic antibody / oxidation ) (2005) (2)
- Tailor-made glycoproteins. (2004) (2)
- Expedient Synthesis of a Library of Heparan Sulfate‐Like “Head‐to‐Tail” Linked Multimers for Structure and Activity Relationship Studies (2022) (2)
- A Molecular Window into the Brain: Special Issue on Molecules and the Brain. (2018) (1)
- Structural Studies of Catalytic Antibodies (1996) (1)
- Distinct glycosaminoglycan chain length and sulfation patterns required for cellular uptake of Tau, Aβ, and α-Synuclein (2017) (1)
- Automated Solid Phase Assisted Synthesis of a Heparan Sulfate Disaccharide Library. (2022) (1)
- CATALYTIC ANTIBODY 28B4 FAB FRAGMENT COMPLEXED WITH HAPTEN (1-[N-4'-NITROBENZYL-N-4'-CARBOXYBUTYLAMINO] METHYLPHOSPHONIC ACID) (1996) (0)
- Faculty Opinions recommendation of Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression. (2002) (0)
- Streamlined synthesis of heparan sulfate glycosaminoglycans and their roles in regulating vasculature development and homeostasis (2020) (0)
- Synthesis of a Systematic 64‐Membered Heparan Sulfate Tetrasaccharide Library (2022) (0)
- Sweet chemical signaling: Understanding the structure-function relationships of carbohydrates in neurobiology and cancer (2012) (0)
- Faculty Opinions recommendation of A three-component Mannich-type reaction for selective tyrosine bioconjugation. (2005) (0)
- Faculty Opinions recommendation of Two-step synthesis of carbohydrates by selective aldol reactions. (2004) (0)
- O-GlcNAc glycosylation: From reductionism to systems biology (2018) (0)
- Decoding the Structure‐Activity Relationships of Glycosaminoglycans in the Brain (2006) (0)
- Cracking the Sulfation Code : Understanding the Interaction Between Glycosaminoglycans and Growth Factors (2006) (0)
- Faculty Opinions recommendation of The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. (2006) (0)
- Synthetic probes for understanding glycosaminoglycan recognition and signaling in the brain (2016) (0)
- Human antibody responses to vaccinia virus D 8 1 Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D 8 (2017) (0)
- Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs) (2018) (0)
- Harnessing chemistry to discover new roles for carbohydrates in neurobiology and cancer (2014) (0)
- O‐GlcNAc Signaling Regulates Cancer Metabolism (2013) (0)
- Investigating the role of O-GlcNAc glycosylation in cancer and neurodegenerative disease (2013) (0)
- Chemical approaches to elucidating the neurobiology of carbohydrates (2010) (0)
- Streamlined methods for the synthesis of heparan sulfate oligosaccharide libraries (2019) (0)
- Streamlined synthesis of core disaccharide building blocks from natural polysaccharides for the generation of heparan sulfate libraries (2019) (0)
- Erratum for the Research Article: “Activation of the Transcriptional Function of the NF-κB Protein c-Rel by O-GlcNAc Glycosylation” by P. Ramakrishnan, P. M. Clark, D. E. Mason, E. C. Peters, L. C. Hsieh-Wilson, D. Baltimore (2014) (0)
- Control of protein phosphate 1 in the dendrite (1999) (0)
- CATALYTIC ANTIBODY 28B4 FAB FRAGMENT (1996) (0)
- Chemical approaches toward a quantitative, systems-level understanding of protein O-GlcNAcylation signaling networks (2019) (0)
- Metabolism Phosphofructokinase 1 Glycosylation Regulates Cell Growth and (2012) (0)
- Faculty Opinions recommendation of A general method for the covalent labeling of fusion proteins with small molecules in vivo. (2003) (0)
- Chemoenzymatic approaches to the imaging and detection of cancer relevant fucosylated glycoconjugates (2013) (0)
- Roles of Glycosaminoglycans in the Ang/Tie Signaling Axis (2018) (0)
- DEVELOPING A CHEMOENZYMATIC LABELING TECHNIQUE TO PROBE O-MANNOSE MODIFIED POLYPEPTIDES by ANURADHA (2008) (0)
- A sulfide oxidation catalytic antibody (1996) (0)
- A systems‐level understanding of glycosylation signaling networks (2018) (0)
- Carbohydrate signaling in the brain (2014) (0)
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