Loren D. Walensky
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Most Influential Person Now
American physician-scientist and pediatric oncologist
Loren D. Walensky's AcademicInfluence.com Rankings
Loren D. Walenskyphilosophy Degrees
Philosophy
#10781
World Rank
#14797
Historical Rank
#2008
USA Rank
Logic
#7631
World Rank
#9455
Historical Rank
#1178
USA Rank
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Philosophy
Loren D. Walensky's Degrees
- Masters Medicine Harvard University
- PhD Biological Chemistry and Molecular Pharmacology Harvard University
Why Is Loren D. Walensky Influential?
(Suggest an Edit or Addition)According to Wikipedia, Loren David Walensky is an American physician-scientist and pediatric oncologist at the Dana–Farber Cancer Institute since 2003 and a professor of pediatrics at the Dana–Farber/Harvard Cancer Center. He researches peptides and oncogenic pathways. In 2013, Walensky became director of the joint MD/PhD program at Harvard Medical School. He is the husband of Rochelle Walensky, former director of the Centers for Disease Control and Prevention.
Loren D. Walensky's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. (2002) (1646)
- Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix (2004) (1179)
- BAX Activation is Initiated at a Novel Interaction Site (2008) (650)
- Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress (2014) (507)
- A stapled BID BH3 helix directly binds and activates BAX. (2006) (388)
- The MCL-1 BH3 Helix is an Exclusive MCL-1 inhibitor and Apoptosis Sensitizer (2010) (354)
- Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide (2007) (351)
- Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma (2014) (335)
- Regulation of AMPA Receptor GluR1 Subunit Surface Expression by a 4.1N-Linked Actin Cytoskeletal Association (2000) (318)
- The Challenge of Drugging Undruggable Targets in Cancer: Lessons Learned from Targeting BCL-2 Family Members (2007) (317)
- SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2 (2015) (314)
- Targeted Disruption of the EZH2/EED Complex Inhibits EZH2-dependent Cancer (2013) (309)
- Dual role of proapoptotic BAD in insulin secretion and beta cell survival (2008) (297)
- Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux. (1995) (285)
- Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm (1995) (268)
- A stapled p53 helix overcomes HDMX-mediated suppression of p53. (2010) (267)
- BH3-triggered structural reorganization drives the activation of proapoptotic BAX. (2010) (266)
- Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic (2010) (257)
- BCL-2 in the crosshairs: tipping the balance of life and death (2006) (244)
- Targeted Disruption of the BCL9/β-Catenin Complex Inhibits Oncogenic Wnt Signaling (2012) (234)
- A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. (2012) (157)
- BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore. (2011) (152)
- Direct and selective small-molecule activation of proapoptotic BAX. (2012) (151)
- Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide. (2007) (147)
- Direct activation of full-length proapoptotic BAK (2013) (143)
- A Novel Neuron-Enriched Homolog of the Erythrocyte Membrane Cytoskeletal Protein 4.1 (1999) (141)
- Biophysical Determinants for Cellular Uptake of Hydrocarbon-Stapled Peptide Helices (2016) (135)
- A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival. (2012) (134)
- Molecular and Functional Characterization of Protein 4.1B, a Novel Member of the Protein 4.1 Family with High Level, Focal Expression in Brain* (2000) (130)
- Protein 4.1R-deficient mice are viable but have erythroid membrane skeleton abnormalities. (1999) (129)
- Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices (2015) (116)
- Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism. (2015) (115)
- The retinoblastoma protein induces apoptosis directly at the mitochondria. (2013) (112)
- Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. (2017) (108)
- Cloning and characterization of 4.1G (EPB41L2), a new member of the skeletal protein 4.1 (EPB41) gene family. (1998) (106)
- BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress (2015) (106)
- The 13-kD FK506 Binding Protein, FKBP13, Interacts with a Novel Homologue of the Erythrocyte Membrane Cytoskeletal Protein 4.1 (1998) (105)
- Evaluation and critical assessment of putative MCL-1 inhibitors (2013) (102)
- Odorant Receptors and Desensitization Proteins Colocalize in Mammalian Sperm (1995) (98)
- A Membrane-targeted BID BCL-2 Homology 3 Peptide Is Sufficient for High Potency Activation of BAX in Vitro* (2006) (91)
- Synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains. (2008) (90)
- Distinct BimBH3 (BimSAHB) stapled peptides for structural and cellular studies. (2014) (78)
- Design of Stapled Antimicrobial Peptides that Overcome Antibiotic Resistance and In Vivo Toxicity (2019) (78)
- Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration (2017) (73)
- Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3. (2013) (69)
- Stapled HIV-1 Peptides Recapitulate Antigenic Structures and Engage Broadly Neutralizing Antibodies (2014) (66)
- Phase I trial of a novel stapled peptide ALRN-6924 disrupting MDMX- and MDM2-mediated inhibition of WT p53 in patients with solid tumors and lymphomas. (2017) (65)
- Chemical Synthesis of Hydrocarbon‐Stapled Peptides for Protein Interaction Research and Therapeutic Targeting (2011) (61)
- Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human. (1998) (61)
- Protein 4.1N Binding to Nuclear Mitotic Apparatus Protein in PC12 Cells Mediates the Antiproliferative Actions of Nerve Growth Factor (1999) (59)
- Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice (2019) (58)
- Iterative optimization yields Mcl-1–targeting stapled peptides with selective cytotoxicity to Mcl-1–dependent cancer cells (2018) (57)
- A novel M(r) 32,000 nuclear phosphoprotein is selectively expressed in cells competent for self-renewal. (1993) (57)
- Distinct distribution of specific members of protein 4.1 gene family in the mouse nephron. (2003) (56)
- Mucosal delivery of a double-stapled RSV peptide prevents nasopulmonary infection. (2014) (56)
- Two Novel Odorant Receptor Families Expressed in Spermatids Undergo 5′-Splicing* (1998) (56)
- Targeting BAX to drug death directly (2019) (55)
- Neurobehavioral deficits in mice lacking the erythrocyte membrane cytoskeletal protein 4.1 (1998) (53)
- Selective Covalent Targeting of Anti-Apoptotic BFL-1 by Cysteine-Reactive Stapled Peptide Inhibitors. (2016) (52)
- Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma (2018) (49)
- Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome. (2010) (49)
- Dissection of the BCL-2 family signaling network with stabilized alpha-helices of BCL-2 domains. (2008) (49)
- A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators (2013) (48)
- Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia (2014) (45)
- Characterization of a core fragment of the rhesus monkey TRIM5α protein (2011) (42)
- Deciphering the nuclear import pathway for the cytoskeletal red cell protein 4.1R. (1999) (40)
- Targeted Disruption of the EZH 2 / EED Complex Inhibits EZH 2-dependent Cancer (2013) (39)
- MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors. (2019) (38)
- Generation of multiple reporter ions from a single isobaric reagent increases multiplexing capacity for quantitative proteomics. (2015) (38)
- Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD. (2018) (37)
- Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells. (2014) (35)
- Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumor suppressor (2017) (35)
- Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor. (2018) (32)
- Allosteric Inhibition of Anti-Apoptotic MCL-1 (2016) (31)
- From mitochondrial biology to magic bullet: navitoclax disarms BCL-2 in chronic lymphocytic leukemia. (2012) (30)
- Cellular Uptake and Ultrastructural Localization Underlie the Pro-apoptotic Activity of a Hydrocarbon-stapled BIM BH3 Peptide. (2015) (30)
- Mechanistic Validation of a Clinical Lead Stapled Peptide that Reactivates p53 by Dual HDM2 and HDMX Targeting (2016) (29)
- Allosteric Sensitization of Pro-Apoptotic BAX (2017) (28)
- Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival (2020) (27)
- Phospho-BAD BH3 mimicry protects β cells and restores functional β cell mass in diabetes. (2015) (25)
- Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization. (2020) (23)
- Synthesis of 10-Substituted “Open-Chain” Analogues of 5,10-Dideaza-5,6,7,8-tetrahydrofolic Acid (DDATHF, Lometrexol) (1992) (22)
- Regulation of mitochondrial ceramide distribution by members of the BCL-2 family[S] (2015) (21)
- Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. (2020) (20)
- The 12 kD FK506 Binding Protein FKBP12 Is Released in the Male Reproductive Tract and Stimulates Sperm Motility (1998) (19)
- Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation (2020) (17)
- Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer. (2018) (17)
- Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides. (2016) (15)
- Bim gene dosage is critical in modulating nephron progenitor survival in the absence of microRNAs during kidney development (2017) (14)
- Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge (2003) (13)
- Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX (2020) (12)
- Brain and Testicular Tumors in Mice with Progenitor Cells Lacking BAX and BAK (2012) (9)
- Photoreactive stapled peptides to identify and characterize BCL-2 family interaction sites by mass spectrometry. (2014) (9)
- Reply to Fernandez-Marrero et al.: Role of BOK at the intersection of endoplasmic reticulum stress and apoptosis regulation (2016) (9)
- Tracking BAX once its trigger is pulled (2011) (9)
- The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core (2021) (8)
- Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress: Miniperspective (2014) (7)
- Hydrocarbon-stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor. (2020) (7)
- Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets (2021) (7)
- Direct BAKtivation (2013) (6)
- Dissecting the Role of Individual Bcl-2 Members in Response and Resistance to Ibrutinib or Venetoclax in CLL (2017) (6)
- Fast Transport of RNA Granules by Direct Interactions with KIF5A/KLC1 Motors Prevents Axon Degeneration (2020) (6)
- Mind the gap: Expediting gender parity in MD-PhD admissions. (2020) (6)
- Protein-protein interactions: A PUMA mechanism unfolds. (2013) (4)
- Targeting a Helix-in-Groove Interaction Between E1 and E2 Blocks Ubiquitin Transfer (2020) (4)
- A nonapoptotic role for BAX and BAK in eicosanoid metabolism. (2015) (4)
- Identification of a Structural Determinant for Selective Targeting of HDMX. (2020) (3)
- Characterizing Native and Hydrocarbon-Stapled Enfuvirtide Conformations with Ion Mobility Mass Spectrometry and Hydrogen-Deuterium Exchange. (2021) (3)
- Stemming danger with Golgified BAX. (2012) (3)
- A redox switch regulates the structure and function of anti-apoptotic BFL-1 (2020) (3)
- A MEMBRANE-TARGETED BID BH3 PEPTIDE IS SUFFICIENT FOR HIGH POTENCY ACTIVATION OF BAX IN VITRO (2006) (2)
- MCL-1 is a master regulator of cancer dependency on fatty acid oxidation (2022) (2)
- Mantle cell lymphoma in cyclin D 1 transgenic mice with Bim-de fi cient B cells (2014) (2)
- 20 Direct Targeting of Pro-apoptotic BAX for Cancer Therapy (2012) (2)
- Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma (2023) (2)
- Abstract C183: Targeted disruption of the BCL9/b-catenin complex inhibits oncogenic WNT signaling. (2013) (2)
- Abstract CT112: A Phase I multicenter trial of the dual MDM2/MDMX inhibitor ALRN-6924 in children and young adults with relapsed/refractory pediatric cancers (2019) (2)
- Playing FullBAK (2013) (2)
- A Stapled BIM BH3 Helix Overcomes the MCL-1-Mediated Apoptotic Blockade of Refractory Hematologic Cancers (2008) (1)
- A Stapled BIM BH3 Helix Restores Apoptosis In Bim-Null Mantle Cell Lymphoma (2010) (1)
- Anti-Leukemic Potency of Stapled BH3 Helices Correlates with Their Capacity for Bifunctional Activation of Apoptotic Pathways. (2006) (1)
- Selective Targeting of the p53-hDM2 Interaction Using Hydrocarbon-Stapled p53 Peptides. (2006) (1)
- Olfactory receptors and the desensitization proteins alpha-rk-2 and beta-arrestin-2 colocalize in mammalian sperm (1994) (1)
- Structural Analysis of a BAX-BIM SAHB Complex Reveals a Novel BH3 Interaction Site on BAX for Therapeutic Activation of Apoptosis (2008) (1)
- Abstract B41: Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices (2014) (1)
- Cheating Death: New Molecules Block BAX. (2019) (1)
- Generation of Potent and Stable GLP-1 Analogues Via "Serine Ligation". (2022) (1)
- Inhibition of FOXP3 by stapled alpha-helical peptides dampens regulatory T cell function (2022) (1)
- 464 Regulation of apoptosis by synthetic helices of the BCL-2 family (2004) (1)
- Interview with Loren D Walensky. (2012) (1)
- Correction: Phase I Trial of ALRN-6924, a Dual Inhibitor of MDMX and MDM2, in Patients with Solid Tumors and Lymphomas Bearing Wild-type TP53 (2022) (1)
- SOX11 Cooperates with CCND1 in Mantle Cell Lymphoma Pathogenesis (2015) (1)
- Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency (2022) (1)
- Abstract 3552: Regulation of immune homeostasis by direct activator BH3-only proteins (2016) (1)
- Abstract 2471: Chemical optimization of direct and selective molecular activators of pro-apoptotic BAX for cancer therapy. (2013) (0)
- Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency (2022) (0)
- Abstract SY06-03: Stapled helical peptides to dissect and target oncogenic protein interactions. (2013) (0)
- Abstract 2158: Targeted intracellular disruption of oncogenic p53/HDM2 and p53/HDMX complexes underlies the therapeutic activity of a stapled peptide drug (2017) (0)
- Abstract 2367: Neural progenitor cells deficient in BAX and BAK manifest progressive hyperplasia and tumorigenesis (2012) (0)
- Hydrocarbon double-stapled stabilized HIV-1 GP41 heptad repeat domain peptides (2017) (0)
- OAB-033: Pre-clinical models of genetically heterogeneous multiple myeloma reveal mechanisms of immune escape and predict clinical immunotherapy outcomes (2022) (0)
- Abstract 4871: Photoreactive stapled peptides to capture cancer proteins and define their sites of interaction (2011) (0)
- Rapid access pediatrics (2013) (0)
- Small Molecule Modulators of Apoptosis (2018) (0)
- Abstract 3553: A novel allosteric mechanism for molecular inhibition of anti-apoptotic MCL-1 (2016) (0)
- A Stapled p53 Helix Targets HDMX to Overcome Nutlin-3 Resistance and Reactivate the p53 Tumor Suppressor Pathway in Cancer (2008) (0)
- Abstract SY37-01: Dissecting the canonical and noncanonical interactions of the BCL-2 family for therapeutic benefit (2014) (0)
- Abstract 1775: Therapeutic reactivation of cell death in refractory hematologic cancers using a broad spectrum BIM BH3 death helix (2011) (0)
- Allosteric Sensitization of Pro-Apoptotic BAX access benefits you. Your story matters (2017) (0)
- A PUMA mechanism unfolds (2014) (0)
- Expression and function of red cell protein 4.1 and its homologues in erythroid and non-erythroid cells (1998) (0)
- S YNTHESIS AND B IOPHYSICAL C HARACTERIZATION OF S TABILIZED α -H ELICES OF BCL-2 D OMAINS (2019) (0)
- Investigating the Relationship Between Helicity and Activity in Antimicrobial Peptides with Stabilized α-Helical Structures (2016) (0)
- Abstract 294: BCL-2 family compensation regulates T cell homeostasis and reveals a BIM:BCL-W axis in T-ALL (2018) (0)
- Pharmacologic Replacement of BIM BH3 Reactivates Apoptosis in Hematologic Cancer and Lymphoproliferative Disease. (2007) (0)
- Glucose Metabolism and Pyruvate Carboxylase Enhanceglutathione Synthesis and Restrict Oxidative Stress in Beta-Cells (2021) (0)
- Abstract 972: Direct activation of pro-apoptotic BAX as a novel strategy for cancer therapy (2012) (0)
- mitochondria The retinoblastoma protein induces apoptosis directly at the Material (2013) (0)
- Abstract 2024: Reactivating apoptosis in BFL-1/A1 driven cancer with cysteine-reactive stapled peptide inhibitors (2017) (0)
- Abstract 1901: Structural basis for selective therapeutic targeting of BFL-1 in cancer by a covalent stapled peptide inhibitor (2018) (0)
- Abstract 3845: A novel selectivity determinant informs the development of next-generation stapled peptide inhibitors of anti-apoptotic BFL-1/A1 (2016) (0)
- Abstract 2954: A noncanonical mechanism for BCL-2 inhibition of pro-apoptotic BAX (2014) (0)
- Stabilized alpha-helix peptides and uses thereof (2004) (0)
- Thérapies et diagnostics du cancer (2011) (0)
- Abstract 4611: Multimodal activation of apoptosis by a hydrocarbon-stapled PUMA BH3 helix. (2013) (0)
- Abstract 951: Direct small-molecule BAX activation in acute myeloid leukemia (2018) (0)
- Stabilized peptide-mediated targeted protein degradation (2018) (0)
- Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice (2019) (0)
- Abstract 2455: BAM38 is a potent and selective pro-apoptotic BAX activator molecule that restores apoptosis in cancer cells. (2013) (0)
- Abstract 2597: Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices (2014) (0)
- Abstract 5476: Small molecule activation of BAX-mediated apoptosis through direct engagement of the BAX trigger site (2011) (0)
- Dissecting the BCL‐2 family interaction network with stapled peptides: mechanistic insights and pharmacologic opportunities (2012) (0)
- Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation (2020) (0)
- Crystal structure of 10E8 Fab in complex with a hydrocarbon-stapled HIV-1 gp41 MPER peptide (2014) (0)
- 555 Inhibition of FOXP3 by stapled alpha-helical peptides alters Regulatory T Cell function (2020) (0)
- Dissecting the Activation Pathway of Pro-Apoptotic BAX: Mechanistic Insights and Pharmacologic Opportunities. (2009) (0)
- Rapid access pediatrics : companion handbook to Oski's pediatrics (1999) (0)
- Multimodal Targeting of the BCL-2 Family in Cancer (2008) (0)
- Abstract 4851: Selective small molecule inhibition of anti-apoptotic MCL-1 (2012) (0)
- Synthesis of 10-Substituted “Open-Chain” Analogues of 5,10-Dideaza-5,6, 7,8-tetrahydrofolic Acid (DDATHF, Lometrexol). (1992) (0)
- Abstract C174: Therapeutic reactivation of p53 through dual targeting of HDM2 and HDMX with a stapled p53 peptide (2009) (0)
- Abstract LB-241: Photoreactive stapled peptides for target discovery in cancer (2011) (0)
- INHIBITION OF FOXP3 BY STAPLED ALPHA-HELICAL PEPTIDES ALTERS REGULATORY T CELL FUNCTION Background Antibody-dependent cell-mediated cytotoxicity (2020) (0)
- A redox switch regulates the structure and function of anti-apoptotic BFL-1 (2020) (0)
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