Loren Williams

Q: What Schools Are Affiliated With Loren Williams

Loren Williams is affiliated with the following schools: California Institute of Technology, Osaka University of Pharmaceutical Sciences, Massachusetts Institute of Technology, Stanford University, University of Copenhagen, Georgia Tech, Duke University

Loren Williams's AcademicInfluence.com Rankings

Loren Williams

Biology

#8987

World Rank

#12136

Historical Rank

#2386

USA Rank

Biochemistry

#2477

World Rank

#2633

Historical Rank

#331

USA Rank

biology Degrees

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Biology

Loren Williams's Degrees

PhD Biophysics Stanford University

Why Is Loren Williams Influential?

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According to Wikipedia, Loren Dean Williams is a biophysicist, biochemist, astrobiologist, and professor in the School of Chemistry and Biochemistry at the Georgia Institute of Technology in Atlanta, Georgia. His research seeks to understand the structural basis for macromolecular reactions, from the role of nucleic acids as targets of chemotherapeutics to the ancestral biochemistry of the ribosome during the origin of life.

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Loren Williams's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Structural comparison of anticancer drug-DNA complexes: adriamycin and daunomycin. (1990) (527)
The B-DNA dodecamer at high resolution reveals a spine of water on sodium. (1998) (351)
RNA backbone: consensus all-angle conformers and modular string nomenclature (an RNA Ontology Consortium contribution). (2008) (235)
X-ray structure of a DNA decamer containing 7,8-dihydro-8-oxoguanine. (1995) (195)
History of the ribosome and the origin of translation (2015) (188)
Structure of DNA-porphyrin complex. (1996) (179)
Cations in charge: magnesium ions in RNA folding and catalysis. (2012) (171)
Structure of the potassium form of CGCGAATTCGCG: DNA deformation by electrostatic collapse around inorganic cations. (1998) (171)
DNA structure: cations in charge? (1999) (166)
Evolution of the ribosome at atomic resolution (2014) (164)
Implications and concepts of polyamine‐nucleic acid interactions (1991) (162)
The origin of RNA and "my grandfather's axe". (2013) (158)
Electrostatic mechanisms of DNA deformation. (2000) (151)
A third mode of DNA binding: Phosphate clamps by a polynuclear platinum complex. (2006) (145)
Peeling the onion: ribosomes are ancient molecular fossils. (2009) (143)
Locating monovalent cations in the grooves of B-DNA. (2001) (127)
Secondary Structures of rRNAs from All Three Domains of Life (2014) (117)
Cations Mediate B-DNA Conformational Heterogeneity† (2000) (112)
RiboVision suite for visualization and analysis of ribosomes. (2014) (106)
Divalent cations stabilize unstacked conformations of DNA and RNA by interacting with base pi systems. (1998) (103)
A novel assay for drug-DNA binding mode, affinity, and exclusion number: scanning force microscopy. (1996) (101)
Scanning Force Microscopy of Small Ligand-Nucleic Acid Complexes: Tris(o-phenanthroline)ruthenium(II) as a Test for a New Assay (1997) (92)
The low-temperature crystal structure of the pure-spermine form of Z-DNA reveals binding of a spermine molecule in the minor groove. (1993) (92)
RNA Folding and Catalysis Mediated by Iron (II) (2012) (90)
Secondary structure and domain architecture of the 23S and 5S rRNAs (2013) (87)
Root of the Tree: The Significance, Evolution, and Origins of the Ribosome. (2020) (85)
Influence of the dynamic positions of cations on the structure of the DNA minor groove: sequence-dependent effects. (2001) (82)
Water ring structure at DNA interfaces: hydration and dynamics of DNA-anthracycline complexes. (1994) (80)
Structure of nogalamycin bound to a DNA hexamer. (1990) (78)
Bidentate RNA-magnesium clamps: on the origin of the special role of magnesium in RNA folding. (2011) (74)
Structure of the pure-spermine form of Z-DNA (magnesium free) at 1-A resolution. (1991) (73)
Fibers from Soybean Protein and Poly(vinyl alcohol) (1999) (69)
Automated identification of RNA conformational motifs: theory and application to the HM LSU 23S rRNA. (2003) (66)
RNA with iron(II) as a cofactor catalyses electron transfer. (2013) (66)
Anthraquinone Photonuclease Structure Determines Its Mode of Binding to DNA and the Cleavage Chemistry Observed (1997) (65)
The Ribosome Challenge to the RNA World (2015) (65)
Protonated base pairs explain the ambiguous pairing properties of O6-methylguanine. (1987) (65)
A recurrent magnesium-binding motif provides a framework for the ribosomal peptidyl transferase center (2009) (64)
Drug-induced DNA repair: X-ray structure of a DNA-ditercalinium complex. (1991) (63)
Intercalation of trioxatriangulenium ion in DNA: binding, electron transfer, x-ray crystallography, and electronic structure. (2003) (63)
Monovalent Cations Sequester within the A-Tract Minor Groove of [d(CGCGAATTCGCG)]2 (1999) (61)
DNA-nogalamycin interactions. (1991) (60)
Translation: The Universal Structural Core of Life (2018) (59)
Selective incorporation of proteinaceous over nonproteinaceous cationic amino acids in model prebiotic oligomerization reactions (2019) (58)
Selective strand scission by intercalating drugs at DNA bulges. (1988) (58)
P22 c2 repressor-operator complex: mechanisms of direct and indirect readout. (2008) (58)
Frozen in Time: The History of Proteins (2017) (56)
Chemical reactivity of potassium permanganate and diethyl pyrocarbonate with B DNA: specific reactivity with short A-tracts. (1990) (55)
Structure of a DNA-bisdaunomycin complex. (1997) (53)
Surprising roles of electrostatic interactions in DNA-ligand complexes. (2003) (50)
The phosphate clamp: a small and independent motif for nucleic acid backbone recognition (2010) (50)
High-resolution structure of an extended A-tract: [d(CGCAAATTTGCG)]2. (2004) (50)
Ternary interactions of spermine with DNA: 4'-epiadriamycin and other DNA: anthracycline complexes. (1990) (49)
Dimers, trimers, and tetramers of cytosine with guanine (1989) (46)
Inhibition of trypsin and thrombin by amino(4-amidinophenyl)methanephosphonate diphenyl ester derivatives: X-ray structures and molecular models. (1996) (45)
Effect of a neutralized phosphate backbone on the minor groove of B-DNA: molecular dynamics simulation studies. (2002) (42)
The hydrogen bonding of cytosine with guanine: Calorimetric and 1H‐NMR analysis of the molecular interactions of nucleic acid bases (1987) (40)
Single nucleotide RNA choreography (2006) (40)
RNA-magnesium-protein interactions in large ribosomal subunit. (2012) (40)
Effects of cationic charge on three-dimensional structures of intercalative complexes: structure of a bis-intercalated DNA complex solved by MAD phasing. (2000) (39)
Multiple prebiotic metals mediate translation (2018) (38)
The Origin of Life: Models and Data (2017) (37)
Mutually stabilizing interactions between proto-peptides and RNA (2020) (37)
Finding 3D motifs in ribosomal RNA structures (2008) (36)
Sequence recognition of DNA by protein-induced conformational transitions. (2010) (35)
The Central Symbiosis of Molecular Biology: Molecules in Mutualism (2017) (34)
Porphyrins. 43. Triplet sublevel emission of platinum tetrabenzoporphyrin by spectrothermal principal component decomposition (1982) (34)
Melting of a DNA hairpin without hyperchromism. (1998) (31)
Folding, Assembly, and Persistence: The Essential Nature and Origins of Biopolymers (2018) (31)
G-Quadruplexes in Human Ribosomal RNA. (2019) (31)
Functional RNAs: combined assembly and packaging in VLPs (2016) (30)
R2DT is a framework for predicting and visualising RNA secondary structure using templates (2021) (30)
Oxyanion-mediated inhibition of serine proteases. (1998) (28)
In Vitro Secondary Structure of the Genomic RNA of Satellite Tobacco Mosaic Virus (2013) (28)
Statistical analysis of RNA backbone (2006) (28)
Specific binding of o-phenanthroline at a DNA structural lesion. (1988) (28)
In a model cytosine:guanine base pair, one amino group rotates and the other does not (1990) (28)
Iron mediates catalysis of nucleic acid processing enzymes: support for Fe(II) as a cofactor before the great oxidation event (2017) (26)
Domain III of the T. thermophilus 23S rRNA folds independently to a near-native state. (2012) (26)
DNA distortion in bis-intercalated complexes. (1994) (26)
Conservation of estrogen receptor function in invertebrate reproduction (2017) (25)
Structure of B-DNA with cations tethered in the major groove. (2005) (24)
Chapter 1:Complexes of Nucleic Acids with Group I and II Cations (2008) (24)
Ribosomal small subunit domains radiate from a central core (2016) (24)
Structure of 11-deoxydaunomycin bound to DNA containing a phosphorothioate. (1990) (24)
The role of minor groove functional groups in DNA hydration. (2003) (23)
Three-Dimensional Structure and Reactivity of a Photochemical Cleavage Agent Bound to DNA (1998) (22)
DNA-ditercalinium interactions: implications for recognition of damaged DNA. (1992) (21)
The phosphate clamp as recognition motif in platinum–DNA interactions (2016) (20)
Supersized Ribosomal RNA Expansion Segments in Asgard Archaea (2019) (20)
RNA tetraloop folding reveals tension between backbone restraints and molecular interactions. (2010) (19)
A review of the role of the sequence-dependent electrostatic landscape in DNA alkylation patterns. (2006) (18)
Strand Breaks in X-Irradiated Crystalline DNA: Alternating CG Oligomers (2003) (18)
Imprint of Ancient Evolution on rRNA Folding. (2016) (18)
Water and Life: The Medium is the Message (2021) (18)
Human ribosomal G-quadruplexes regulate heme bioavailability (2020) (17)
A blueprint for academic laboratories to produce SARS-CoV-2 quantitative RT-PCR test kits (2020) (17)
Cutting in-line with iron: ribosomal function and non-oxidative RNA cleavage (2019) (15)
Yeast rRNA Expansion Segments: Folding and Function. (2016) (14)
The Ancient Heart of the Ribosomal Large Subunit: A Response to Caetano-Anolles (2015) (14)
Mechanism of RNA double helix-propagation at atomic resolution. (2009) (14)
Eukaryotic Ribosomal Expansion Segments as Antimicrobial Targets. (2017) (13)
Between Objectivity and Whim: Nucleic Acid Structural Biology (2005) (13)
Molecular Recognition of Watson–Crick‐Like Purine–Purine Base Pairs (2011) (13)
Profusion of G-quadruplexes on both subunits of metazoan ribosomes (2019) (13)
Specific minor groove solvation is a crucial determinant of DNA binding site recognition (2014) (12)
Nonenzymatic Ligation of DNA with a Reversible Step and a Final Linkage that Can Be Used in PCR (2012) (11)
Stress granules form in Brachionus manjavacas (Rotifera) in response to a variety of stressors. (2013) (11)
Protein-free ribosomal RNA folds to a near-native state in the presence of Mg2+ (2017) (11)
Preparation of long templates for RNA in vitro transcription by recursive PCR. (2012) (11)
Migration of electrons and holes in crystalline d(CGATCG)-anthracycline complexes X-irradiated at 4 K. (1998) (10)
Scanning probe visualization of electrostatically immobilized intercalating drug–nucleic acid complexes (1995) (10)
Circular Permutation Obscures Universality of a Ribosomal Protein (2018) (8)
Ancestral Interactions of Ribosomal RNA and Ribosomal Proteins. (2017) (8)
Fold Evolution before LUCA: Common Ancestry of SH3 Domains and OB Domains (2021) (8)
Secondary structure and domain architecture of the 23 S and 5 S rRNAs (2013) (8)
The origin of life: look up and look down. (2012) (8)
Variable temperature infrared spectroscopy of cytosine-guanine base pairs: tautomerism versus polarization. (1992) (8)
RNA: packaged and protected by VLPs (2018) (8)
Asymmetry and dynamics in bis-intercalated DNA. (1995) (8)
ProteoVision: web server for advanced visualization of ribosomal proteins (2021) (8)
A blueprint for academic labs to produce SARS-CoV-2 RT-qPCR test kits (2020) (7)
Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine (2021) (7)
Crystal Structure of Proflavine in Complex with a DNA hexamer duplex (2010) (7)
Indirect readout of DNA sequence by p22 repressor: roles of DNA and protein functional groups in modulating DNA conformation. (2013) (7)
Buzz about RT-qPCR: An RT-qPCR formulation for SARS-CoV-2 detection using reagents produced at Georgia Institute of Technology (2020) (7)
X-ray crystallography of DNA-drug complexes. (2001) (6)
R2DT: computational framework for template-based RNA secondary structure visualisation across non-coding RNA types (2020) (4)
Folding and Catalysis Near Life’s Origin: Support for Fe 2+ as a Dominant Divalent Cation (2018) (4)
Thioesters provide a plausible prebiotic path to proto-peptides (2022) (4)
TwinCons: Conservation score for uncovering deep sequence similarity and divergence (2021) (4)
Effects of Cationic Charge on Three‐Dimensional Structures of Intercalative Complexes: Structure of a Bis‐intercalated DNA Complex Solved by MAD Phasing (2000) (4)
Distribution of monoesters resulting from the esterification of a mixture of glycols and triols (1967) (4)
Modular-DNA Programmed Molecular Construction of “Fixed” of 2D and 3D-Au Nanoparticle Arrays (2014) (4)
Proteotoxic stress promotes entrapment of ribosomes and misfolded proteins in a shared cytosolic compartment (2020) (4)
Protein: Feeling the groove of DNA (2011) (3)
Application of anomalous diffraction methods to the study of DNA and DNA-complexes. (2010) (3)
Adaptation and Exaptation: From Small Molecules to Feathers (2022) (3)
The Evolution of Protein Folds by Creative Destruction (2022) (2)
Constraining prebiotic chemistry through a better understanding of Earth’s earliest environments (2020) (2)
Role of Cations in RNA Folding and Function (2018) (2)
Structure of a DNA-porphyrin complex (1996) (2)
Ferrous iron folds rRNA and mediates translation (2018) (2)
DIVERSITY OF WATER RING SIZE AT DNA INTERFACES: HYDRATION AND DYNAMICS OF DNA-ANTHRACYCLINE COMPLEXES (1994) (2)
Eukaryotic-like ribosomal RNA region in Lokiarchaeota (2019) (2)
Water-Based Dynamic Depsipeptide Chemistry: Building Block Recycling and Oligomer Distribution Control Using Hydration–Dehydration Cycles (2022) (2)
Supplementary text, figures, and tables. (2021) (1)
Something old, something new, something borrowed, something blue: the anaerobic microbial ancestry of aerobic respiration. (2022) (1)
Protein Fold Evolution by Creative Destruction (2022) (1)
Frontiers in Prebiotic Chemistry and Early Earth Environments (2022) (1)
Understanding the Early Major Transitions in Evolutionary History Part 2: Ancient Evolution of Biological Systems and the Biosphere (2021) (1)
Ribosome dynamics and the evolutionary history of ribosomes (2015) (1)
Differential Oligomerization of Alpha versus Beta Amino Acids and Hydroxy Acids in Abiotic Proto-Peptide Synthesis Reactions (2022) (1)
rRNA expansion segment 7 in eukaryotes: from Signature Fold to tentacles (2022) (1)
BETA-TRYPSIN PHOSPHONATE INHIBITED (1996) (0)
Dimers, Trimers, and Tetramers of Cytosine with Guanine. (1989) (0)
Understanding the Early Major Transitions in Evolutionary History Part 1: Stages in the Emergence of Complex Life (2021) (0)
Goldilocks and RNA: Where Mg2+ concentration is just right (2021) (0)
Conservation of estrogen receptor function in invertebrate reproduction (2017) (0)
Crystal structure of one turn of G/C rich B-DNA revisited (2010) (0)
in press Methods in Enzymology (2000) (0)
Locating monovalent cations in one turn of G/C rich B-DNA (2010) (0)
Base pairing properties of O/sup 6/-methylguanine (1986) (0)
Crystal Structure Analysis of the B-DNA Dodecamer CGCGAATTCGCG with Thallium Ions. (2001) (0)
G-Quadruplexes Ribosomal RNA (2019) (0)
Mutually stabilizing interactions between proto-peptides and RNA (2020) (0)
Thioesters Provide a Robust Path to Prebiotic Peptides (2021) (0)
Molecules in Mutualism: Prebiotic Mixtures of Cationic Depsipeptides and RNA (2019) (0)
Crystal Structure of [d(CGCGAA(Z3dU)(Z3dU)CGCG)]2, Z3dU:5-(3-aminopropyl)-2'-deoxyuridine, in presence of thallium I. (2005) (0)
The Origins and Essential Nature of Biopolymers (2018) (0)
Protonated base pairs explain the ambiguous pairing properties of 06-methylguanine ( hydrogen bonding / DNA structure / protonated cytosine / mutagenesis ) (2012) (0)
A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2 (2005) (0)
The Central Symbiosis of Molecular Biology: Molecules in Mutualism (2017) (0)
ANALYSIS OF RNA BACKBONE By Eli Hershkovitz Guillermo Sapiro (2004) (0)
BETA-TRYPSIN COMPLEXED WITH ACPU (1998) (0)
OP-GBEV200171 1694..1710 (2020) (0)
Frozen in Time: The History of the Ribosome (2017) (0)
A Backbone binding DNA complex (2007) (0)
The Ribosome: Pumping Iron Fe 2+ substitutes for Mg 2+ in ancient and modern ribosomal RNA (2013) (0)
Circular Permutation Obscures Universality of a Ribosomal Protein (2018) (0)
near-native state 23 S rRNA folds independently to a T . thermophilus Domain III of the Material Supplemental (2012) (0)
2'-Deoxycytidine-N3-cyanoborane (1996) (0)
CATALYTIC ABILITIES OF THE SCHISTOSOMA MANSONI HAMMERHEAD RIBOZYME WITH MUTATED SUBSTRATES IN ICE (2016) (0)
The Ancient Heart of the Ribosomal Large Subunit: A Response to Caetano-Anolles (2015) (0)
CRYSTAL STRUCTURE ANALYSIS OF THE POTASSIUM FORM OF B-DNA DODECAMER CGCGAATTCGCG (2000) (0)
RNA and Protein: A Match Made in the Hadean (2014) (0)
Ferrous iron mediates translation (2018) (0)
Crystal Structure of the P22 c2 Repressor protein in complex with the synthetic operator 9T (2008) (0)
Dynamic G-quadruplexes on the surface of the human ribosome (2018) (0)
Folding, Assembly, and Persistence: The Essential Nature and Origins of Biopolymers (2018) (0)
G-quadruplex formation on specific surface-exposed regions of the human ribosomal RNA (2018) (0)
Depletion assisted hemin affinity (DAsHA) proteomics reveals an expanded landscape of heme-binding proteins in the human proteome (2022) (0)
Creative destruction: New protein folds from old (2022) (0)
Translation in a Box: Orthogonal Evolution in the Saccharomyces cerevisiae Mitochondrion (2023) (0)
Where Did We Come From - The Ribosome (2010) (0)
Chemistry and Why We Hate It (2008) (0)
The Ribosome Challenge to the RNA World (2015) (0)
Ima Preprint Series # 1964 Statistical Analysis of Rna Backbone (2004) (0)
The Origin of Life: Models and Data (2017) (0)
Biopolymers; Emergence, Assembly, and Origins (2019) (0)
Protonated base pairs explain the a properties of 06-methylguanine (hydrogen bonding/DNA structure/protonated cytosine/mutagenesi (2016) (0)
Elements of Style: Manuscript/Thesis/Figure Preparation in the Williams Group (2018) (0)
ASSESSING THE CONFORMATIONAL SHIFT OF TRANSFER RNA- PHENYLALANINE IN THE PRESENCE OF IRON(II) AND MAGNESIUM(II) (2013) (0)
Are You Smarter than a High School Student (2011) (0)
DNA Distortion in &Intercalated Complexest*' (1994) (0)
Updates on the Origin of Life (2012) (0)
The application of detailed structural data bases has now culminated in the successful design of a new generation of bisanthracyclines that form ultratight DNA complexes (1997) (0)
Crystal structure of the P22 c2 repressor protein in complex with synthetic operator 9C in the presence of Rb (2010) (0)

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