Lori L. Isom

Q: What Schools Are Affiliated With Lori L. Isom

Lori L. Isom is affiliated with the following schools: Washington University in St. Louis, University of Michigan, Vanderbilt University, University of Washington, University of California, San Francisco

Lori L. Isom's AcademicInfluence.com Rankings

Lori L. Isom

Medical

#3263

World Rank

#3725

Historical Rank

#501

USA Rank

Pharmacology

#442

World Rank

#496

Historical Rank

#41

USA Rank

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Medical

Lori L. Isom's Degrees

PhD Pharmacology University of California, San Francisco
Bachelors Pharmacy University of California, San Francisco

Why Is Lori L. Isom Influential?

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According to Wikipedia, Lori L. Isom is an American pharmacologist, an elected Fellow of the American Association for the Advancement of Science, and a member of the National Academy of Medicine. Biography Isom was raised in Oshkosh, Wisconsin. She received her BA from Washington University in St. Louis in 1982 and her PhD in Pharmacology from Vanderbilt University in 1987. She completed her postdoctoral fellowship in 1993 at the University of Washington in the Catterall lab. Currently, she serves as the chair of the Department of Pharmacology at the University of Michigan, as well as a Professor of Molecular and Integrative Physiology and Professor of Neurology.

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Lori L. Isom's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel. (1992) (676)
Auxiliary subunits of voltage-gated ion channels (1994) (557)
Structure and function of the β2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif (1995) (474)
Sodium Channel β Subunits: Anything but Auxiliary (2001) (312)
Loss of Plakophilin-2 Expression Leads to Decreased Sodium Current and Slower Conduction Velocity in Cultured Cardiac Myocytes (2009) (293)
Differential Control of Clustering of the Sodium Channels Nav1.2 and Nav1.6 at Developing CNS Nodes of Ranvier (2001) (289)
Sodium Channel β Subunits Mediate Homophilic Cell Adhesion and Recruit Ankyrin to Points of Cell-Cell Contact* (2000) (263)
Mice Lacking Sodium Channel β1 Subunits Display Defects in Neuronal Excitability, Sodium Channel Expression, and Nodal Architecture (2004) (258)
Na+ Channel β Subunits: Overachievers of the Ion Channel Family (2011) (243)
Early Painful Diabetic Neuropathy Is Associated with Differential Changes in Tetrodotoxin-sensitive and -resistant Sodium Channels in Dorsal Root Ganglion Neurons in the Rat* (2004) (241)
Interactions Between Ankyrin-G, Plakophilin-2, and Connexin43 at the Cardiac Intercalated Disc (2011) (228)
Open-Channel Block by the Cytoplasmic Tail of Sodium Channel β4 as a Mechanism for Resurgent Sodium Current (2005) (225)
A Functional Null Mutation of SCN1B in a Patient with Dravet Syndrome (2009) (224)
Tenascin-R Is a Functional Modulator of Sodium Channel β Subunits* (1999) (217)
Functional Co-expression of the 1 and Type IIA Subunits of Sodium Channels in a Mammalian Cell Line (*) (1995) (210)
Characterization of Sodium Channel α- and β-Subunits in Rat and Mouse Cardiac Myocytes (2001) (200)
Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel β2-subunits (2002) (195)
Dravet syndrome patient‐derived neurons suggest a novel epilepsy mechanism (2013) (193)
Sodium channel beta subunits: anything but auxiliary. (2001) (192)
Contactin Associates with Na+ Channels and Increases Their Functional Expression (2001) (192)
The adult rat brain β1 subunit modifies activation and inactivation gating of multiple sodium channel α subunits (1994) (186)
Sodium channels as macromolecular complexes: implications for inherited arrhythmia syndromes. (2005) (180)
Electrophysiology and beyond: Multiple roles of Na+ channel β subunits in development and disease (2010) (179)
Sodium channel β subunits: emerging targets in channelopathies. (2015) (167)
A Novel Epilepsy Mutation in the Sodium Channel SCN1A Identifies a Cytoplasmic Domain for β Subunit Interaction (2004) (166)
Regulation of Persistent Na Current by Interactions between β Subunits of Voltage-Gated Na Channels (2009) (165)
Therapeutic potential for phenytoin: targeting Nav1.5 sodium channels to reduce migration and invasion in metastatic breast cancer (2012) (161)
Structural Requirements for Interaction of Sodium Channel β1 Subunits with Ankyrin* (2002) (161)
Cloning, Localization, and Functional Expression of Sodium Channel β1A Subunits* (2000) (160)
Molecular Determinants of Na+ Channel Function in the Extracellular Domain of the β1 Subunit* (1998) (156)
Functional and Biochemical Analysis of a Sodium Channel β1 Subunit Mutation Responsible for Generalized Epilepsy with Febrile Seizures Plus Type 1 (2002) (142)
Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. (2007) (137)
Modulation of Cardiac Na+ Channel Expression in Xenopus Oocytes by β1 Subunits (*) (1995) (137)
The role of sodium channels in cell adhesion. (2002) (133)
Sodium Channel β2 Subunits Regulate Tetrodotoxin-Sensitive Sodium Channels in Small Dorsal Root Ganglion Neurons and Modulate the Response to Pain (2006) (129)
Tyrosine-phosphorylated and Nonphosphorylated Sodium Channel β1 Subunits Are Differentially Localized in Cardiac Myocytes* (2004) (128)
Antisense oligonucleotides increase Scn1a expression and reduce seizures and SUDEP incidence in a mouse model of Dravet syndrome (2020) (126)
Altered Cardiac Electrophysiology and SUDEP in a Model of Dravet Syndrome (2013) (125)
Sodium Channel β1 Subunit-mediated Modulation of Nav1.2 Currents and Cell Surface Density Is Dependent on Interactions with Contactin and Ankyrin* (2004) (124)
Na+ channel subunits and Ig domains (1996) (123)
Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes. (2011) (121)
An Emerging Role for Voltage-Gated Na+ Channels in Cellular Migration: Regulation of Central Nervous System Development and Potentiation of Invasive Cancers (2008) (120)
Heterophilic Interactions of Sodium Channel β1 Subunits with Axonal and Glial Cell Adhesion Molecules* (2004) (119)
Functional reciprocity between Na+ channel Nav1.6 and β1 subunits in the coordinated regulation of excitability and neurite outgrowth (2010) (119)
Upregulation of the Voltage-Gated Sodium Channel β2 Subunit in Neuropathic Pain Models: Characterization of Expression in Injured and Non-Injured Primary Sensory Neurons (2005) (116)
Sodium channel beta subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contact. (2000) (116)
Characterization of sodium channel alpha- and beta-subunits in rat and mouse cardiac myocytes. (2001) (115)
Voltage-Gated Na+ Channel β1 Subunit-Mediated Neurite Outgrowth Requires Fyn Kinase and Contributes to Postnatal CNS Development In Vivo (2008) (113)
A novel adhesion molecule in human breast cancer cells: voltage-gated Na+ channel beta1 subunit. (2009) (104)
Primary Structure and Functional Expression of the β 1 Subunit of the Rat Brain Sodium Channel (1992) (104)
Voltage-Gated Na+ Channel β1B: A Secreted Cell Adhesion Molecule Involved in Human Epilepsy (2011) (96)
The role of non-pore-forming β subunits in physiology and pathophysiology of voltage-gated sodium channels. (2014) (93)
Sodium Channel β1 Subunits Promote Neurite Outgrowth in Cerebellar Granule Neurons* (2004) (89)
The Sodium Channel Accessory Subunit Navβ1 Regulates Neuronal Excitability through Modulation of Repolarizing Voltage-Gated K+ Channels (2012) (86)
Voltage-gated Na+ channels: Potential for β subunits as therapeutic targets (2008) (78)
The adult rat brain beta 1 subunit modifies activation and inactivation gating of multiple sodium channel alpha subunits. (1994) (75)
Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability (2012) (73)
Efficacy Loss of the Anticonvulsant Carbamazepine in Mice Lacking Sodium Channel β Subunits via Paradoxical Effects on Persistent Sodium Currents (2010) (72)
Role of Sodium Channels in Epilepsy. (2016) (69)
Functional co-expression of the beta 1 and type IIA alpha subunits of sodium channels in a mammalian cell line. (1995) (66)
Identification of the Cysteine Residue Responsible for Disulfide Linkage of Na+ Channel α and β2 Subunits* (2012) (65)
The intracellular segment of the sodium channel β1 subunit is required for its efficient association with the channel α subunit (2001) (62)
Conduction Block in PMP22 Deficiency (2010) (60)
The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation (2018) (60)
Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets. (2008) (60)
Neuronal hyperexcitability in a mouse model of SCN8A epileptic encephalopathy (2017) (59)
Alpha 2-adrenergic receptors accelerate Na+/H+ exchange in neuroblastoma X glioma cells. (1987) (56)
More Than a Pore: Ion Channel Signaling Complexes (2014) (54)
Loss of Na+ channel β2 subunits is neuroprotective in a mouse model of multiple sclerosis (2009) (53)
Modulation of cardiac Na+ channel expression in Xenopus oocytes by beta 1 subunits. (1995) (47)
Sodium channel beta1 subunits promote neurite outgrowth in cerebellar granule neurons. (2004) (46)
Voltage-Gated Sodium Channel β Subunits and Their Related Diseases. (2017) (45)
Late Na+ current and protracted electrical recovery are critical determinants of the aging myopathy (2015) (44)
Voltage-gated sodium channel β subunits: The power outside the pore in brain development and disease (2017) (44)
Cardiac arrhythmia in a mouse model of sodium channel SCN8A epileptic encephalopathy (2016) (44)
Voltage-Gated Na+ Channels: Not Just for Conduction. (2016) (42)
Na+ Channel Scn1b Gene Regulates Dorsal Root Ganglion Nociceptor Excitability in Vivo* (2011) (40)
Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts. (2014) (40)
Ordered Assembly of the Adhesive and Electrochemical Connections within Newly Formed Intercalated Disks in Primary Cultures of Adult Rat Cardiomyocytes (2010) (39)
Scn1b deletion leads to increased tetrodotoxin‐sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts (2015) (38)
The intracellular segment of the sodium channel beta 1 subunit is required for its efficient association with the channel alpha subunit. (2001) (35)
Channelopathy as a SUDEP Biomarker in Dravet Syndrome Patient-Derived Cardiac Myocytes (2018) (34)
Voltage-Gated Sodium Channel β1/β1B Subunits Regulate Cardiac Physiology and Pathophysiology (2018) (33)
β subunits: Players in neuronal hyperexcitability? (2002) (32)
Loss of β1 accessory Na+ channel subunits causes failure of carbamazepine, but not of lacosamide, in blocking high‐frequency firing via differential effects on persistent Na+ currents (2012) (31)
Variant-specific changes in persistent or resurgent sodium current in SCN8A-related epilepsy patient-derived neurons. (2020) (31)
The voltage-gated Na+ channel β3 subunit does not mediate trans homophilic cell adhesion or associate with the cell adhesion molecule contactin (2009) (29)
Multiple receptors linked to inhibition of adenylate cyclase accelerate Na+/H+ exchange in neuroblastoma x glioma cells via a mechanism other than decreased cAMP accumulation. (1987) (29)
Scn2b Deletion in Mice Results in Ventricular and Atrial Arrhythmias (2016) (28)
Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome (2020) (27)
I. Cellular and molecular biology of sodium channel beta-subunits: therapeutic implications for pain? (2000) (27)
β1-C121W Is Down But Not Out: Epilepsy-Associated Scn1b-C121W Results in a Deleterious Gain-of-Function (2016) (27)
Untangling the Dravet Syndrome Seizure Network: The Changing Face of a Rare Genetic Epilepsy (2014) (26)
Beta subunits: players in neuronal hyperexcitability? (2002) (26)
Biocatalytic Detoxification of Paralytic Shellfish Toxins (2019) (25)
scn1bb, a Zebrafish Ortholog of SCN1B Expressed in Excitable and Nonexcitable Cells, Affects Motor Neuron Axon Morphology and Touch Sensitivity (2008) (24)
Cannabinoid-induced depression of synaptic transmission is switched to stimulation when dopaminergic tone is increased in the globus pallidus of the rodent (2016) (23)
Cloning and expression of a zebrafish SCN1B ortholog and identification of a species-specific splice variant (2007) (23)
Expression and regulation of voltage-gated sodium channel β1 subunit protein in human gliosis-associated pathologies (2003) (21)
Sodium Channel b Subunits Mediate Homophilic Cell Adhesion and Recruit Ankyrin to Points of Cell-Cell Contact* (2000) (21)
SCN1B‐linked early infantile developmental and epileptic encephalopathy (2019) (21)
Drugging the undruggable: gabapentin, pregabalin and the calcium channel α2δ subunit (2016) (21)
Pathobiology of Visceral Pain : Molecular Mechanisms and Theraputic Implications (2000) (20)
SHORT COMMUNICATION Sodium channel β1‐subunit expression is increased in reactive astrocytes in a rat model for mesial temporal lobe epilepsy (2002) (20)
Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome (2019) (20)
α-Helix-to-Random-Coil Transition of Two-Chain, Coiled Coils. Experiments on the Thermal Denaturation of α-Tropomyosin and β-Tropomyosin (1984) (17)
Floxed allele for conditional inactivation of the voltage‐gated sodium channel β1 subunit Scn1b (2007) (14)
Developmental and Regulatory Functions of Na(+) Channel Non-pore-forming β Subunits. (2016) (14)
Dravet Syndrome: A Developmental and Epileptic Encephalopathy (2019) (14)
Precision medicine for genetic epilepsy on the horizon: Recent advances, present challenges, and suggestions for continued progress (2022) (13)
NaV1.5 and Regulatory β Subunits in Cardiac Sodium Channelopathies (2014) (12)
Physiologic biomechanics enhance reproducible contractile development in a stem cell derived cardiac muscle platform (2021) (11)
Scn2b, a voltage-gated sodium channel beta2 gene on mouse chromosome 9. (1996) (10)
Scn1b deletion in adult mice results in seizures and SUDEP (2019) (10)
PKCβ co-localizes with the dopamine transporter in mesencephalic neurons (2010) (9)
Sodium channel β1 subunits participate in regulated intramembrane proteolysis-excitation coupling (2021) (9)
Sodium channel β1 subunits are post-translationally modified by tyrosine phosphorylation, S-palmitoylation, and regulated intramembrane proteolysis (2020) (9)
Beyond Dravet Syndrome: Characterization of a Novel, More Severe SCN1A-Linked Epileptic Encephalopathy (2019) (9)
Pathobiology of visceral pain: Molecular mechanisms and therapeutic implications. I. Cellular and molecular biology of sodium channel β- subunits: Therapeutic implications for pain? (2000) (9)
The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6 (2020) (8)
Opposing Phenotypes in Dravet Syndrome Patient-Derived Induced Pluripotent Stem Cell Neurons: Can Everyone be Right? (2017) (7)
Modulation of the effects of class Ib antiarrhythmics on cardiac NaV1.5-encoded channels by accessory NaVβ subunits (2021) (7)
Dravet Syndrome: Novel Approaches for the Most Common Genetic Epilepsy (2021) (6)
On the preparation and properties of earthworm tropomyosin (1981) (5)
Neonatal Scn1b-null mice have sinoatrial node dysfunction, altered atrial structure, and atrial fibrillation (2022) (5)
Mapt deletion fails to rescue premature lethality in two models of sodium channel epilepsy (2018) (5)
Sodium Channel β1 Subunits: Overachievers of the Ion Channel Family (2014) (5)
Dramatic Improvement in Seizures With Phenytoin Treatment in an Individual With Refractory Epilepsy and a SCN1B Variant. (2020) (5)
Is Targeting of Compensatory Ion Channel Gene Expression a Viable Therapeutic Strategy for Dravet Syndrome? (2019) (4)
and β1 subunits in the coordinated regulation of excitability and neurite outgrowth (2010) (4)
Variant-specific changes in persistent or resurgent Na+ current in SCN8A-EIEE13 iPSC-derived neurons (2020) (3)
Expecting the Unexpected: Lack of in Vivo Network Defects in an Scn1a Model of Dravet Syndrome (2016) (3)
On the realization of the helix-coil theory for protein chains in solutions containing dodecyl sulfate. Experiments on α-tropomyosin and bovine serum albumin (1983) (3)
“It Was the Interneuron with the Parvalbumin in the Hippocampus!” “No, it Was the Pyramidal Cell with the Glutamate in the Cortex!” Searching for Clues to the Mechanism of Dravet Syndrome – the Plot Thickens (2014) (3)
Gastrointestinal symptoms and channelopathy-associated epilepsy. (2021) (3)
Adhesion of human breast cancer cell lines: role of voltage-gated sodium channel β1 subunit (2006) (3)
Excitatory and inhibitory neuron defects in a mouse model of Scn1b‐linked EIEE52 (2020) (2)
Characterization of Sodium Channel &agr;- and &bgr;-Subunits in Rat and Mouse Cardiac Myocytes (2001) (2)
Modulation of Kv1 Voltage-Gated Potassium Channels by Sodium Channel Beta Subunits (2012) (2)
Subcellular dynamics and functional activity of the cleaved Na+ channel β1 subunit intracellular domain (2021) (1)
Mitochondrial oxidative stress contributes to diastolic dysfunction through impaired mitochondrial dynamics (2022) (1)
Hidden behavioral fingerprints in epilepsy (2023) (1)
Voltage-gated ion channels (2013) (1)
AB16-5: Knock out of the Β2-subunit of voltage-gated sodium channels causes arrhythmias and disarrangement of sodium channel β-subunits in the heart (2006) (1)
Subcellular dynamics and functional activity of the cleaved intracellular domain of the Na+ channel β1 subunit (2022) (1)
SUMOylation of Neuronal K+ Channels: A Potential Therapeutic Pathway for Epilepsy and SUDEP? (2014) (1)
Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome (2019) (0)
Chapter 7 – Communicating Science (2015) (0)
Biomechanics and Myofibrillar Alignment Enhance Contractile Development and Reproducibility in Stem Cell Derived Cardiac Muscle (2021) (0)
Smart Patch Clamp (2018) (0)
The role of cation-chloride co-transporters in cardiovascular and respiratory abnormalities and SUDEP (2020) (0)
Investigation of the Association of SCN1B with Cardiac Junctional and Ion Channel Proteins at the Intercalated Disc (2010) (0)
TEM - badp1 - Part 3/8 (2018) (0)
Abstract 18393: Plakophilin-2, Ankyrin-G and Connexin43 Mutually Interact to Regulate Intercellular Coupling and Sodium Channel Function. Implications to Arrhythmogenic Cardiomyopathies? (2010) (0)
STORM Localizations - Part 1/3 (2018) (0)
Patient-Specific Induced Pluripotent Stem Cell Cardiac Myocytes as Predictors of Sudep Risk (2016) (0)
Sudden Cardiac Death in a Severe Form of Childhood Epilepsy: Mice & Men (2013) (0)
Plasma Neurofilament Light as a Biomarker for Pediatric Patients with Huntington ’ s Disease Potential Sudden Unexpected Death in Epilepsy (SUDEP) Biomarkers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes with DEPDC5 Loss-of-Function (2020) (0)
Abstract 461: Sodium Influx Modulates the Modality of Cardiac Relaxation (2019) (0)
Modulation of voltage‐gated potassium channels by sodium channel SCN1b subunits (2012) (0)
Colloquium 9: Structural and Molecular Dissection of the Node of Ranvier (2008) (0)
Abstract 17043: Enhanced Na + Influx Alters Myocyte Mechanics and Diastolic Function (2018) (0)
Dorsal root ganglion (DRG) neurons that express beta 2 (β2) subunits normally and after axotomy (2003) (0)
Therapeutic Potential of Targeting Regulated Intramembrane Proteolysis Mechanisms of Voltage-Gated Ion Channel Subunits and Cell Adhesion Molecules (2022) (0)
Defects of Oligodendrocyte Migration in the Scn1b−/− Mouse Model of Dravet Syndrome (2019) (0)
4346 Potential Sudden Unexpected Death in Epilepsy (SUDEP) Biomarkers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes with DEPDC5 Loss-of-Function (2020) (0)
DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse models (2023) (0)
STORM Localizations - Part 3/3 (2018) (0)
Optical mapping - Part 1/3 (2018) (0)
Abstract 16919: Haploinsufficiency of Scn1b Encoding Sodium Channel Beta1 Subunit Alters Cardiac Function (2017) (0)
Abstract 14787: Mitochondrial Oxidative Stress From Increased NADPH Oxidase 4 Levels Induces Paroxysmal Atrial Fibrillation (2019) (0)
Sodium channel b 1-subunit expression is increased in reactive astrocytes in a rat model for mesial temporal lobe epilepsy (0)
Ablation of two Major Phosphorylation Sites in RyR2 Alter Sarcoplamic Reticulum Calcium Handling and Increases the Propensity to Atrial Fibrillation (2016) (0)
TEM - badp1 - Part 5/8 (2018) (0)
Abstract 2814: Loss of Plakophilin-2 Expression Leads to Decreased Sodium Current and Slower Conduction Velocity in Cultured Cardiac Myocytes (2009) (0)
Nervous System Development and Potentiation of Invasive Cancers An Emerging Role for Voltage-Gated Na + Channels in Cellular Migration : Regulation of Central (2008) (0)
Mechanisms of Epilepsy and Neuronal Synchronization Gordon Research Conference Power Hour Summary (2019) (0)
TEM - badp1 - Part 7/8 (2018) (0)

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What Schools Are Affiliated With Lori L. Isom?

Lori L. Isom is affiliated with the following schools:

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