Lorraine S. Symington
#124,850
Most Influential Person Now
Biologist
Lorraine S. Symington's AcademicInfluence.com Rankings
Lorraine S. Symingtonbiology Degrees
Biology
#8325
World Rank
#11385
Historical Rank
#2319
USA Rank
Biochemistry
#1795
World Rank
#1932
Historical Rank
#290
USA Rank
Molecular Biology
#1995
World Rank
#2027
Historical Rank
#232
USA Rank
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Biology
Lorraine S. Symington's Degrees
- PhD Molecular Biology University of California, Berkeley
- Masters Biochemistry Stanford University
Why Is Lorraine S. Symington Influential?
(Suggest an Edit or Addition)According to Wikipedia, Lorraine S. Symington is a British-American geneticist. As the Harold S. Ginsberg Professor and Director of Graduate Studies of Microbiology & Immunology at Columbia University, her laboratory uses genetic, biochemical and molecular approaches to understand mechanisms of homology-directed double-strand break repair using the yeast Saccharomyces cerevisiae as an experimental system.
Lorraine S. Symington's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Double-strand break end resection and repair pathway choice. (2011) (1338)
- Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing (2008) (1025)
- Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair (2002) (1021)
- Recombination proteins in yeast. (2004) (863)
- The Nuclease Activity of Mre11 Is Required for Meiosis but Not for Mating Type Switching, End Joining, or Telomere Maintenance (1999) (455)
- DNA end resection: many nucleases make light work. (2009) (423)
- Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway? (2015) (419)
- Template switching during break-induced replication (2007) (317)
- Mechanism and regulation of DNA end resection in eukaryotes (2016) (309)
- Break-induced replication: What is it and what is it for? (2008) (306)
- Ku prevents Exo1 and Sgs1‐dependent resection of DNA ends in the absence of a functional MRX complex or Sae2 (2010) (289)
- Crystal structure of a Rad51 filament (2004) (279)
- Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae (2014) (266)
- Functional differences and interactions among the putative RecA homologs Rad51, Rad55, and Rad57 (1995) (244)
- A Rad52 homolog is required for RAD51-independent mitotic recombination in Saccharomyces cerevisiae. (1996) (241)
- Nucleases and helicases take center stage in homologous recombination. (2009) (237)
- End resection at double-strand breaks: mechanism and regulation. (2014) (221)
- RPA coordinates DNA end resection and prevents formation of DNA hairpins. (2013) (219)
- Exonuclease I of Saccharomyces cerevisiae functions in mitotic recombination in vivo and in vitro (1997) (204)
- RAD51-Dependent Break-Induced Replication in Yeast (2004) (199)
- EXO1-A multi-tasking eukaryotic nuclease. (2004) (198)
- DNA end resection--unraveling the tail. (2011) (189)
- Overlapping functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 nucleases in DNA metabolism. (2001) (182)
- Role of RAD 52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair (2002) (180)
- The Mre11 Nuclease Is Not Required for 5′ to 3′ Resection at Multiple HO-Induced Double-Strand Breaks (2004) (169)
- Break-induced replication occurs by conservative DNA synthesis (2013) (162)
- RPA Antagonizes Microhomology-Mediated Repair of DNA Double-Strand Breaks (2014) (158)
- Mus81 and Yen1 promote reciprocal exchange during mitotic recombination to maintain genome integrity in budding yeast. (2010) (156)
- Multiple pathways for homologous recombination in Saccharomyces cerevisiae. (1995) (139)
- The yeast recombinational repair protein Rad59 interacts with Rad52 and stimulates single-strand annealing. (2001) (134)
- Use of a chromosomal inverted repeat to demonstrate that the RAD51 and RAD52 genes of Saccharomyces cerevisiae have different roles in mitotic recombination. (1994) (130)
- Mutations in yeast Rad51 that partially bypass the requirement for Rad55 and Rad57 in DNA repair by increasing the stability of Rad51–DNA complexes (2002) (126)
- Homologous recombination is required for the viability of rad27 mutants. (1998) (119)
- Expansions and contractions of the genetic map relative to the physical map of yeast chromosome III (1988) (109)
- Mutations in Mre11 Phosphoesterase Motif I That Impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 Complex Stability in Addition to Nuclease Activity (2005) (101)
- RAD51 Is Required for the Repair of Plasmid Double-Stranded DNA Gaps from Either Plasmid or Chromosomal Templates (2000) (99)
- The Cdk/cDc14 module controls activation of the Yen1 holliday junction resolvase to promote genome stability. (2014) (88)
- DNA Repair Mechanisms and Their Biological Roles in the Malaria Parasite Plasmodium falciparum (2014) (87)
- Partial purification of an enzyme from Saccharomyces cerevisiae that cleaves Holliday junctions. (1985) (85)
- Suppressors of a Saccharomyces cerevisiae pkc1 mutation identify alleles of the phosphatase gene PTC1 and of a novel gene encoding a putative basic leucine zipper protein. (1995) (83)
- Mutation of the gene encoding protein kinase C 1 stimulates mitotic recombination in Saccharomyces cerevisiae (1994) (83)
- Aberrant Double-Strand Break Repair Resulting in Half Crossovers in Mutants Defective for Rad51 or the DNA Polymerase δ Complex (2009) (78)
- SnapShot: Homologous Recombination in DNA Double-Strand Break Repair (2010) (68)
- Decreased meiotic intergenic recombination and increased meiosis I nondisjunction in exo1 mutants of Saccharomyces cerevisiae. (2000) (68)
- Intramolecular recombination of linear DNA catalyzed by the Escherichia coli RecE recombination system. (1985) (67)
- Role of the Saccharomyces cerevisiae Rad51 Paralogs in Sister Chromatid Recombination (2008) (65)
- Template Switching During Break-Induced Replication Is Promoted by the Mph1 Helicase in Saccharomyces cerevisiae (2014) (59)
- Alteration of gene conversion tract length and associated crossing over during plasmid gap repair in nuclease-deficient strains of Saccharomyces cerevisiae. (2000) (59)
- Some disassembly required: role of DNA translocases in the disruption of recombination intermediates and dead-end complexes. (2006) (59)
- Aberrant Double-Strand Break Repair inrad51 Mutants of Saccharomyces cerevisiae (2000) (58)
- The Requirement for ATP Hydrolysis by Saccharomyces cerevisiae Rad51 Is Bypassed by Mating-Type Heterozygosity or RAD54 in High Copy (2002) (58)
- A novel allele of RAD52 that causes severe DNA repair and recombination deficiencies only in the absence of RAD51 or RAD59. (1999) (57)
- Role of the Mre11 Complex in Preserving Genome Integrity (2018) (57)
- 8 Recombination in Yeast (1991) (55)
- Xrs2 Dependent and Independent Functions of the Mre11-Rad50 Complex. (2016) (55)
- Mre11-Sae2 and RPA Collaborate to Prevent Palindromic Gene Amplification. (2015) (54)
- Sae2 promotes DNA damage resistance by removing the Mre11–Rad50–Xrs2 complex from DNA and attenuating Rad53 signaling (2015) (51)
- Genetic recombination of homologous plasmids catalyzed by cell-free extracts of saccharomyces cerevisiae (1983) (50)
- The Rad52-Rad59 complex interacts with Rad51 and replication protein A. (2003) (49)
- DNA End Resection: Mechanism and Control. (2021) (49)
- Mph1 and Mus81-Mms4 prevent aberrant processing of mitotic recombination intermediates. (2013) (49)
- Transposon-specified site-specific recombination. (1982) (49)
- RPA Stabilization of Single-Stranded DNA Is Critical for Break-Induced Replication. (2016) (46)
- DNA Polymerase Delta Synthesizes Both Strands during Break-Induced Replication. (2019) (45)
- The rad51-K191R ATPase-Defective Mutant Is Impaired forPresynaptic Filament Formation (2006) (44)
- Transposon‐encoded site‐specific recombination: nature of the Tn3 DNA sequences which constitute the recombination site res. (1983) (43)
- The Rad1–Rad10 nuclease promotes chromosome translocations between dispersed repeats (2012) (43)
- Gene targeting in yeast is initiated by two independent strand invasions. (2004) (42)
- Suppression of the Double-Strand-Break-Repair Defect of the Saccharomyces cerevisiae rad57 Mutant (2009) (42)
- Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways (2019) (41)
- RAD51-independent inverted-repeat recombination by a strand-annealing mechanism. (2011) (38)
- Extensive DNA End Processing by Exo1 and Sgs1 Inhibits Break-Induced Replication (2010) (36)
- A 5'-3' exonuclease from Saccharomyces cerevisiae is required for in vitro recombination between linear DNA molecules with overlapping homology (1993) (33)
- Genetic analysis of a meiotic recombination hotspot on chromosome III of Saccharomyces cerevisiae. (1991) (31)
- Stimulation of meiotic recombination in yeast by an ARS element. (1993) (30)
- Rad51 paralog complex Rad55–Rad57 acts as a molecular chaperone during homologous recombination (2020) (30)
- Sae2 antagonizes Rad9 accumulation at DNA double-strand breaks to attenuate checkpoint signaling and facilitate end resection (2018) (29)
- Opposing roles for DNA structure‐specific proteins Rad1, Msh2, Msh3, and Sgs1 in yeast gene targeting (2005) (28)
- Replication protein A prevents promiscuous annealing between short sequence homologies: Implications for genome integrity (2015) (28)
- Breaking Up Just Got Easier to Do (2009) (27)
- Defining the influence of Rad51 and Dmc1 lineage-specific amino acids on genetic recombination (2019) (26)
- Crossed-stranded DNA structures for investigating the molecular dynamics of the Holliday junction. (1993) (25)
- Meiotic recombination within the centromere of a yeast chromosome (1988) (25)
- Unique and overlapping functions of the Exo1, Mre11 and Pso2 nucleases in DNA repair. (2008) (24)
- Focus on recombinational DNA repair (2005) (24)
- Double‐strand‐break repair and recombination catalyzed by a nuclear extract of Saccharomyces cerevisiae. (1991) (23)
- Mitotic recombination within the centromere of a yeast chromosome. (1988) (23)
- A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation (2016) (22)
- Overcoming the chromatin barrier to end resection (2012) (20)
- Stressing Out About RAD52. (2016) (18)
- Resection Activity of the Sgs1 Helicase Alters the Affinity of DNA Ends for Homologous Recombination Proteins in Saccharomyces cerevisiae (2013) (18)
- Rad51 gain-of-function mutants that exhibit high affinity DNA binding cause DNA damage sensitivity in the absence of Srs2 (2008) (15)
- Sgs1—The Maestro of Recombination (2012) (14)
- Genetic recombination catalyzed by cell-free extracts of Saccharomyces cerevisiae. (1984) (14)
- Resolving resolvases: the final act? (2008) (13)
- Xrs2 and Tel1 Independently Contribute to MR-Mediated DNA Tethering and Replisome Stability (2018) (13)
- New Year's Resolution--Resolving Resolvases (2004) (12)
- Mechanism for inverted-repeat recombination induced by a replication fork barrier (2022) (11)
- CDK and Mec1/Tel1-catalyzed phosphorylation of Sae2 regulate different responses to DNA damage (2019) (11)
- DNA end resection during homologous recombination. (2021) (10)
- DNA repair: Making the cut (2014) (9)
- Plasmid recombination intermediates generated in a Saccharomyces cerevisiae cell-free recombination system (1985) (9)
- Phosphoproteomics reveals a distinctive Mec1/ATR signaling response upon DNA end hyper‐resection (2021) (8)
- A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation (2017) (8)
- Keeping it real: MRX–Sae2 clipping of natural substrates (2017) (8)
- Sgs1 and Exo1 suppress targeted chromosome duplication during ends-in and ends-out gene targeting. (2014) (7)
- Processing of DNA Double-Strand Breaks in Yeast. (2018) (7)
- Interstitial telomere sequences disrupt break-induced replication and drive formation of ectopic telomeres (2020) (7)
- Efficient DNA double-strand break formation at single or multiple defined sites in the Saccharomyces cerevisiae genome (2020) (6)
- Resection activity of the Sgs 1 helicase alters the affinity of DNA ends for homologous recombination proteins in Saccharomyces cerevisiae (2013) (5)
- A Novel Allele of RAD 52 That Causes Severe DNA Repair and Recombination Deficiencies Only in the Absence of RAD 51 or RAD 59 (1999) (5)
- Identification of Nucleases and Phosphatases by Direct Biochemical Screen of the Saccharomyces cerevisiae Proteome (2009) (4)
- A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation (2017) (4)
- The dark side of homology-directed repair. (2021) (4)
- Recombination in yeast and the recombinant DNA technology. (1989) (4)
- Transposon-encoded site-specific recombination (1982) (3)
- What's hot for recombination. (1997) (2)
- Erratum: Decreased meiotic intergenic recombination and increased meiosis I nondisjunction in exo1 mutants of saccharomyces cerevisiae (Genetics 156 (1549-1557)) (2001) (2)
- Molecular biology. New Year's resolution--resolving resolvases. (2004) (2)
- Initiation and completion of spontaneous mitotic recombination occur in different cell cycle phases (2010) (2)
- Faculty Opinions recommendation of Chromosomal translocations in yeast induced by low levels of DNA polymerase a model for chromosome fragile sites. (2005) (1)
- Focus on recombinational DNA repair Workshop on Recombinational DNA Repair and its Links with DNA Replication and Chromosome Maintenance (2013) (1)
- Recognition for Discoveries in DNA Repair. (2019) (1)
- Long-range DNA end resection supports homologous recombination by checkpoint activation rather than extensive homology generation (2022) (1)
- Mechanism for inverted-repeat recombination induced by a replication fork barrier (2022) (1)
- Dysfunctional Telomeres The Role of Double-Strand Break Repair Pathways at Functional and (2014) (0)
- Faculty Opinions recommendation of Rad54 protein promotes branch migration of Holliday junctions. (2006) (0)
- Faculty Opinions recommendation of Endonucleolytic processing of covalent protein-linked DNA double-strand breaks. (2005) (0)
- Mutations in yeast Rad51 that partially bypass the requirement for Rad55 and Rad57 in DNA repair by increasing the stability of Rad51–DNA complexes (2013) (0)
- Double-strand breaks induce inverted duplication chromosome rearrangements by a DNA polymerase δ and Rad51-dependent mechanism (2023) (0)
- Mechanism and regulation of DNA end processing (2012) (0)
- Faculty Opinions recommendation of The RecF protein antagonizes RecX function via direct interaction. (2006) (0)
- Gap Repair in Vitro Catalyzed by Cell-Free Extracts from Yeast (1992) (0)
- The Mre11 Nuclease Is Not Required for 5 (cid:2) to 3 (cid:2) Resection at Multiple HO-Induced Double-Strand Breaks (2004) (0)
- Homologous recombination induced by a replication fork barrier requires cooperation between strand invasion and strand annealing activities (2021) (0)
- Intrachromosomal Recombination in Yeast. (2021) (0)
- 21.4.4 Recombination in yeast and the recombinant DNA technology (1989) (0)
- Mechanisms and Consequences of Break-Induced Replication (2016) (0)
- The rad51-K191R ATPase-Defective Mutant Is Impaired for Presynaptic Filament Formation (cid:1) † (2006) (0)
- Sequence and chromatin features guide DNA double-strand break resection initiation. (2023) (0)
- Faculty Opinions recommendation of Impairment of replication fork progression mediates RNA polII transcription-associated recombination. (2005) (0)
- A Crystal Structure of the Rad51 Filament (2004) (0)
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