Louis Siminovitch

Louis Siminovitch's AcademicInfluence.com Rankings

Louis Siminovitch

Biology

#714

World Rank

#1246

Historical Rank

Molecular Biology

#466

World Rank

#475

Historical Rank

biology Degrees

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Biology

Why Is Louis Siminovitch Influential?

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According to Wikipedia, Louis Siminovitch was a Canadian molecular biologist. He was a pioneer in human genetics, researcher into the genetic basis of muscular dystrophy and cystic fibrosis, and helped establish Ontario programs exploring genetic roots of cancer.

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Louis Siminovitch's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

THE DISTRIBUTION OF COLONY-FORMING CELLS AMONG SPLEEN COLONIES. (1963) (932)
A STOCHASTIC MODEL OF STEM CELL PROLIFERATION, BASED ON THE GROWTH OF SPLEEN COLONY-FORMING CELLS. (1964) (877)
THE EFFECT OF DIFFERING DEMANDS FOR BLOOD CELL PRODUCTION ON DNA SYNTHESIS BY HEMOPOIETIC COLONY-FORMING CELLS OF MICE. (1965) (500)
An air-drying technique for flattening chromosomes in mammalian oells grown in vitro. (1958) (485)
CYTOLOGICAL EVIDENCE FOR A RELATIONSHIP BETWEEN NORMAL HEMATOPOIETIC COLONY-FORMING CELLS AND CELLS OF THE LYMPHOID SYSTEM (1968) (446)
On the nature of hereditable variation in cultured somatic cells (1976) (432)
Ouabain-resistant mutants of mouse and hamster cells in culture (1974) (385)
The cellular basis of the genetically determined hemopoietic defect in anemic mice of genotype Sl-Sld. (1965) (345)
Spleen-Colony Formation in Anemic Mice of Genotype WW (1964) (329)
A cytological study of the capacity for differentiation of normal hemopoietic colony‐forming cells (1967) (285)
THE DEVELOPMENT OF VACCINIA VIRUS IN EARLE'S L STRAIN CELLS AS EXAMINED BY ELECTRON MICROSCOPY (1961) (279)
DECLINE IN COLONY-FORMING ABILITY OF MARROW CELLS SUBJECTED TO SERIAL TRANSPLANTATION INTO IRRADIATED MICE. (1964) (247)
Selection and characterization of eight phenotypically distinct lines of lectin-resistant chinese hamster ovary cells (1975) (223)
Multidrug-resistance phenotype in Chinese hamster ovary cells. (1983) (207)
DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression (1982) (203)
Chinese hamster ovary cells selected for resistance to the cytotoxicity of phytohemagglutinin are deficient in a UDP-N-acetylglucosamine--glycoprotein N-acetylglucosaminyltransferase activity. (1975) (191)
Genetics and physiology of defective lysogeny in K12 (λ): Studies of early mutants☆ (1966) (169)
The morphogenesis of bacteriophage lambda. IV. Identification of gene products and control of the expression of the morphogenetic information. (1972) (158)
Expression of Bacterial β-Galactosidase in Animal Cells (1982) (152)
Complementation between mutants of CHO cells resistant to a variety of plant lectins (1977) (146)
Mutations in bacteriophage lambda affecting host cell lysis. (1967) (114)
Evidence for a relationship between mouse hemopoietic stem cells and cells forming colonies in culture. (1968) (108)
Isolation of temperature-sensitive mutants of L-cells. (1970) (104)
The proliferative capacity of antigen-sensitive precursors of hemolytic plaque-forming cells. (1966) (101)
Mutations in bacteriophage lambda affecting particle morphogenesis. (1968) (95)
Mammalian cells with altered forms of RNA polymerase II. (1972) (94)
Lysis defective mutants of bacteriophage lambda: genetics and physiology of S cistron mutants. (1971) (88)
The morphogenesis of bacteriophage lambda. II. Identification of the principal structural proteins. (1970) (86)
Electron microscopy studies of mutants of lambada bacteriophage. I. General description and quantitation of viral products. (1968) (86)
The isolation and preliminary characterization of somatic cell mutants resistant to the protein synthesis inhibitor—Emetine (1976) (83)
RADIOSENSITIVITY OF THE IMMUNE RESPONSE TO SHEEP RED CELLS IN THE MOUSE, AS MEASURED BY THE HEMOLYTIC PLAQUE METHOD. (1965) (82)
The molecular basis of emetine resistance in chinese hamster ovary cells: Alteration in the 40S ribosomal subunit (1977) (82)
Mutants of CHO cells resistant to the protein synthesis inhibitors, cryptopleurine and tylocrebrine: genetic and biochemical evidence for common site of action of emetine, cryptopleurine, tylocrebine, and tubulosine. (1977) (74)
Genetic markers for quantitative mutagenesis studies in Chinese hamster ovary cells: characteristics of some recently developed selective systems. (1980) (74)
Biosynthesis and Mode of Action of a Colicine. (1952) (73)
Lysis defective mutants of bacteriophage lambda: on the role of the S function in lysis. (1971) (71)
Increase of cellular constituents in x-irradiated mammalian cells. (1958) (69)
A Transplantation Assay for Mouse Cells Responsive to Antigenic Stimulation by Sheep Erythrocytes.∗ (1965) (66)
The morphogenesis of bacteriophage lambda: I. Purification and characterization of λ heads and λ tails (1970) (66)
Propagation of L strain mouse cells in suspension. (1957) (65)
The cellular composition of hemopoietic spleen colonies (1967) (64)
Selection by [3H] amino acids of CHO-cell mutants with altered leucyl- and asparagyl-transfer RNA synthetases (1975) (63)
Evidence for functional hemizygosity at the Emtr locus in CHO cells through segregation analysis (1978) (62)
Radiation responses of hemopoietic colony-forming cells derived from different sources. (1964) (62)
Selective and nonselective isolation of temperature‐sensitive mutants of mouse L‐cells and their characterization (1971) (61)
The morphogenesis of phage lambda. V. Form-determining function of the genes required for the assembly of the head. (1972) (61)
Alpha-Amanitin resistance of RNA polymerase II in mutant Chinese hamster ovary cell lines. (1976) (59)
Isolation, structure and expression of mammalian genes for histidyl-tRNA synthetase. (1987) (53)
Production of serum-blocking material by mutants of the left arm of the λ chromosome (1969) (50)
The Morphogenesis of Bacteriophage Lambda III. Identification of Genes Specifying Morphogenetic Proteins (1971) (49)
Introduction and recovery of a selectable bacterial gene from the genome of mammalian cells (1982) (49)
The action of T2 bacteriophage ghosts on Escherichia coli B. (1955) (47)
STUDIES ON THE TRANSFORMATION OF HAMSTER EMBRYO CELLS IN CULTURE BY POLYOMA VIRUS. I. PROPERTIES OF TRANSFORMED AND NORMAL CELLS. (1963) (45)
Persistence of freely replicating SV40 recombinant molecules carrying a selectable marker in permissive simian cells (1982) (44)
THE CYCLE OF MULTIPLICATION OF VACCINIA VIRUS IN EARLE'S STRAIN L CELLS. II. INITIATION OF DNA SYNTHESIS AND MORPHOGENESIS. (1964) (43)
Selection and characterization of eight phenotypically distinct lines of lectin-resistant Chinese hamster ovary cell. (1975) (43)
The Cellular Basis for the Defect in Haemopoiesis in Flexed‐Tailed Mice (1966) (43)
The proliferative state of antigen-sensitive precursors of hemolysin-producing cells, determined by the use of the inhibitor, vinblastine. (1966) (43)
Structural determinants responsible for the biological activity of (-)-emetine, (-)-cryptopleurine, and (-)-tylocrebrine: structure-activity relationship among related compounds. (1980) (43)
Diphtheria-toxin-resistant mutants of CHO cells affected in protein synthesis: A novel phenotype (1978) (42)
Host survival following infection with or induction of bacteriophage lambda mutants. (1968) (42)
Characterization of an unusual defective lysogenic strain of Escherichia coli K12(λ) (1965) (39)
The RNA polymerase II of an α-amanitin-resistant Chinese hamster ovary cell line (1976) (38)
ISOLATION OF VARIANT CELL LINES DURING SERIAL TRANSPLANTATION OF HEMATOPOIETIC CELLS DERIVED FROM FETAL LIVER. (1964) (37)
Isolation and characterization of mutants of human diploid fibroblasts resistant to diphtheria toxin. (1978) (37)
α-amanitin resistance: a dominant mutation in CHO cells (1975) (37)
Selection of Chinese hamster cells auxotrophic for thymidine by 1-#x03B2;-D-arabinofuranosyl cytosine (1979) (36)
A Cytopathogenic Agent from a Mammary Tumour in a C3H Mouse that produces Tumours in Swiss Mice and Hamsters (1959) (36)
Chromosomal alterations associated with overproduction of asparagine synthetase in albizziin-resistant Chinese hamster ovary cells (1983) (34)
Transfer of codominant markers by isolated metaphase chromosomes in Chinese hamster ovary cells. (1977) (34)
The Cellular Basis for the Defect in Haemopoiesis in Flexed‐Tailed Mice. (1967) (33)
Transfer of anchorage independence by isolated metaphase chromosomes in hamster cells (1977) (33)
Proliferation of Monkey Kidney Cells in Rotating Cultures (1955) (31)
EFFECTS OF BACTERIAL ENDOTOXIN ON HEMOPOIETIC COLONY‐FORMING CELLS IN THE SPLEENS OF NORMAL MICE AND MICE OF GENOTYPE S1/S1 (1970) (31)
The effect of plethora on growth and differentiation of normal hemopoietic colony-forming cells transplanted in mice of genotype W/Wv. (1967) (30)
Studies in vitro, in vivo, and by electron microscope of a virus recovered from a C3H mouse mammary tumor: relationship to polyoma virus. (1960) (29)
Conservation of desoxyribonucleic acid phosphorus in animal cells propagated in vitro. (1956) (29)
Purification and properties of dihydrofolate reductase from methotrexate-sensitive and methotrexate-resistant Chinese hamster ovary cells. (1977) (28)
The relationship between transformation and somatic mutation in human and Chinese hamster cells (1978) (27)
SIGNIFICANCE OF RIBONUCLEIC ACID AND DEOXYRIBONUCLEIC ACID TURNOVER STUDIES (1956) (27)
Evidence for variation in the number of functional gene copies at the AmaR locus in chinese hamster cell lines (1978) (27)
Analysis of a break in chromosome 14 mapping to the region of the immunoglobulin heavy chain locus. (1983) (24)
Analysis of Differentiating Clones Derived from Marrow (1967) (24)
The metabolic stability of nucleic acids in Escherichia coli. (1956) (23)
Comparison of phenotypic expression with genotypic transformation by using cloned, selectable markers (1982) (23)
The role of independent and dependent stem cells in the control of hemopoietic and immunologic responses. (1965) (23)
Multiplication of Single Mammalian Cells in a Nonbicarbonate Medium (1960) (21)
[Induction of the production of bacteriophages in lysogenic bacteria]. (1950) (21)
The nature of conditionally lethal temperature‐sensitive mutations in somatic cells (1978) (21)
ASSESSMENT OF VIABILITY OF FROZEN BONE MARROW CELLS USING A CELL‐CULTURE METHOD (1968) (20)
The histopathological sequence in viral carcinogenesis in the hamster kidney. (1960) (20)
Synthesis of nucleic acids in Escherichia coli. (1955) (19)
Molecular cloning of a cDNA for Chinese hamster ovary asparagine synthetase. (1984) (19)
Amplification of the gene for histidyl-tRNA synthetase in histidinol-resistant Chinese hamster ovary cells. (1985) (18)
Linkage of markers controlling consecutive biochemical steps in CHO cells as demonstrated by chromosome transfer (1977) (18)
Transfer of the marker for morphologically transformed phenotype by isolated metaphase chromosomes in hamster cells (1978) (18)
Induction of tumors in Syrian hamsters by a cytopathogenic virus derived from a C3H mouse mammary tumor. (1960) (17)
Conservation of RNA and DNA phosphorus in strain L (Earle) mouse cells. (1957) (16)
On the mechanism of the inhibition of glycolysis by glyceraldehyde. (1951) (16)
Excision of lambda prophage: effects on host survival. (1968) (15)
Expression of bacterial beta-galactosidase in animal cells. (1982) (15)
Relevance of spontaneous in vivo tumor-host cell fusion to tumor progression and metastasis evaluated using a series of lectin-resistant mutant tumor sublines. (1983) (15)
An in vitro analysis of the dominance of emetine sensitivity in Chinese hamster ovary cell hybrids. (1978) (15)
DNA-mediated gene transfer of beta-aspartylhydroxamate resistance into Chinese hamster ovary cells. (1981) (15)
MULTIPLICATION OF ANIMAL CELLS IN SUSPENSION MEASURED BY COLONY COUNTS. (1957) (14)
RADIOBIOLOGICAL STUDIES OF VACCINIA VIRUS. (1963) (14)
[Biosynthesis of a colicin and its mode of action]. (1952) (14)
Isolation and preliminary characterization of Sindbis virus-resistant Chinese hamster ovary cells. (1981) (12)
Biochemical modifications in lysogenic B. megatherium 899 (1) after induction with ultraviolet light. (1952) (12)
α -Amanitin-resistant Mutants of Mammalian Cells and the Regulation of RNA Polymerase II Activity (1976) (11)
Mechanisms of genetic variation in chinese hamster ovary cells (1985) (11)
Fine structure analysis of the Chinese hamster AS gene encoding asparagine synthetase. (1989) (11)
Production of serum-blocking material by mutants of the left arm of the lambda chromosome. (1969) (10)
Characterization of single step albizziin-resistant Chinese hamster ovary cell lines with elevated levels of asparagine synthetase activity. (1985) (9)
ON THE ORIGIN OF MUTANTS OF SOMATIC CELLS (1979) (9)
The chromosome complement of the Rhesus monkey (Macaca mulatta) determined in kidney cells cultivated in vitro (1957) (9)
Structural analysis of the 5' region of the chromosomal gene for hamster histidyl-tRNA synthetase. (1987) (8)
An improved method for radioautography of erythropoietic cells labeled with Fe 55 or Fe 59. (1966) (8)
Problems with Co-Funding in Canada (2005) (7)
Isolation and characterization of Chinese hamster ovary cell mutants resistant to the amino acid analogβ-aspartyl hydroxamate (1982) (7)
The morphogenesis of bacteriophage lambda. I. Purification and characterization of lambda heads and lambda tails. (1970) (6)
CELL-CELL INTERACTIONS IN VITRO: THEIR RELATION TO DIFFERENTIATION AND CARCINOGENESIS. (1963) (6)
Antenatal diagnosis of neural tube defects in Canada: extension of a collaborative study. (1979) (5)
The proteins generated by the bacterial genes of gal-transducing phages. (1972) (5)
Genetics and physiology of defective lysogeny in K12 (lambda): studies of early mutants. (1966) (4)
Viral carcinogenesis with particular reference to in vivo and in vitro studies with the polyoma virus. (1961) (4)
Biochemical modifications of the bacterial host during bacteriophage development. (1953) (4)
Characterization of an unusual defective lysogenic strain of Escherichia coli K-12(lambda). (1965) (4)
Genetic factors affecting the control of hemopoiesis. (1966) (4)
Genetic manipulation: now is the time to consider controls. (1973) (3)
Excision of the lambda prophage: effects on linkage relationships of Escherichia coli chromosome. (1968) (3)
Mechanism of Glyceraldehyde Inhibition of Glycolysis (1950) (3)
The RNA polymerase II of an alpha-amanitin-resistant Chinese hamster ovary cell line. (1976) (3)
Selection and characterization of chinese hamster ovary cells resistant to the cytotoxicity of lectins (1976) (2)
Genetic analysis by chromosome-mediated gene transfer in hamster cells. (1977) (2)
Some biological problems in cancer biochemistry. (1960) (2)
[Induction of lysis of a lysogenic bacterium without production of bacteriophages]. (1951) (2)
Genetic characterization of methotrexate-resistant chinese hamster ovary cells (1976) (2)
[Comparison between the induced biosynthesis of colicine and of bacteriophage and between their mode of action]. (1953) (2)
Isolation ofTemperature-Sensitive MutantsofL-Cells* (1970) (1)
Host-cell interactions in mice bearing isologous hemopoietic grafts. Abstr. (1964) (1)
Small science: big science will prevail. (2012) (1)
My friend, François Jacob, an icon among icons. (2014) (1)
Importance of national centres of research to Canadian health care and medical science. (1986) (1)
[Induced biosynthesis of an enzyme during the development of bacteriophages in Escherichia coli K 12]. (1952) (1)
New ventures, to attract new resources. (1986) (1)
From the golden age Origins of molecular biology: A tribute to Jacques Monod. A. Lwoff and A. Ullmann, eds. New York: Academic Press. 246 pp. $17.50 (1979) (1)
Temperature-sensitive conditional lethal mutants of somatic cells. (1970) (1)
Genetic Variants of Cultured Animal Cells (1982) (1)
A Recognition: Of Microbes and Life . Les Microbes et la Vie. Jacques Monod and Ernest Borek , Eds. Columbia University Press, New York, 1971. xx, 312 pp., illus. $12.50. (1972) (0)
Isolation and characterization of Chinese hamster ovary cell mutants resistant to the amino acid analog beta-aspartyl hydroxamate. (1982) (0)
AN IMPROVED METHOD FOR RADIOAUTOGRAPHY OF ERYTHROPOIETIC CELLS LABELED WITH $sup 55$Fe OR $sup 59$Fe (1966) (0)
Of Microbes and Life. Les Microbes et la Vie. Jacques Monod and Ernest Borek, Eds. Columbia University Press, New York, 1971. xx, 312 pp., illus. $12.50 (1972) (0)
[Relation between the abortive development of the prophage in Bacillus megatherium 91 (1) and the synthesis of desoxyribonucleic acid]. (1951) (0)
NOTES Expression of Bacterial f3-Galactosidase in Animal Cells (2003) (0)
A tribute to Margaret W. Thompson (2015) (0)
[Inductive properties of virulent mutants of a modified phage]. (1953) (0)
Genetic manipulation: now is the time to consider controls. (1973) (0)
[Cytologic studies on a lysogenic Bacillus megatherium during the development of bacteriophage]. (1952) (0)
Evidence for Separate Control of Haemopoietic and Immunologic Functions in the Mouse (1966) (0)
DNA-mediated gene transfer of fl-aspartylhydroxamate resistance into Chinese hamster ovary cells ( asparagine synthetase / DNA transformation / somatic cell genetics ) (0)
The chemical basis of heredity in viruses and cells. (1962) (0)
Cytogenetics and Somatic Cell Genetics of Malignancy Workshop (1982) (0)
Advances in cancer research: bench to bedside. (1990) (0)
Till J E & McCulloch E A. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat. Res. 14:213-22, 1961 (2001) (0)
Electron microscope study of a variant of polyoma virus during tumor induction in hamster kidney. Abstr. (1960) (0)
The cellular basis for the defect in hemopoiesis in mice with hertwig's anemia. Abstr. (1966) (0)
DNA Amplification in Histidinol-Resistant Chinese Hamster Ovary Cells (2020) (0)
Growth and differentiation of marrow cells transplanted in anemic and plethoric mice of genotype w/w(v). Abstr. (1966) (0)
Stem Cell Science and the Lasker Award—Let the Science Not Be Lost in Translation (2007) (0)
Studies on the control of spleen colony formation. Abstr. (1964) (0)
Relationship between hemopoietic colony-forming cells and survival of mice following total-body irradiation. Abstr. (1964) (0)
Gordon Tomkins (1975) (0)
[Formation of a "colicine" induced by ultraviolet irradiation of Escherichia coli]. (1951) (0)
Amplification of the gene for histidyl-tRNA synthetase in histidinol-resistant Chinese hamster ovary cells (1985) (0)
[Induction of the development of probacteriophage by reducing substances]. (1952) (0)
Synthesis by Hemopoietic Colony-Forming Cells of Mice The Effect of Differing Demands for Blood Cell Production on DNA (2011) (0)
[Biochemical modifications during the development of bacteriophages in a lysogenic bacteria]. (1951) (0)

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