Louise Purton
#184,246
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Australian biologist
Louise Purton's AcademicInfluence.com Rankings
Louise Purtonbiology Degrees
Biology
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#19781
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Cell Biology
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#902
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Molecular Biology
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#2782
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Biology
Louise Purton's Degrees
- PhD Biological Sciences University of Melbourne
Why Is Louise Purton Influential?
(Suggest an Edit or Addition)According to Wikipedia, Louise E. Purton is an Australian biologist who is Professor of Medicine and head of the Stem Cell Regulation Laboratory at St. Vincent's Institute of Medical Research in Melbourne. Her research considers the stem cells responsible for the production of blood cells and the regulations of haematopoietic diseases. She was awarded the International Society for Experimental Hematology McCulloch & Till Award in 2022. She has experienced profound bilateral hearing loss since the age of three and has been recognised for her work supporting Equity and Diversity, particularly amongst women and people with disability, and is a member of the AAMRI Gender, Equity and Diversity and Inclusion group GEDI.
Louise Purton's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A Microenvironment-Induced Myeloproliferative Syndrome Caused by Retinoic Acid Receptor γ Deficiency (2007) (506)
- Rb Regulates Interactions between Hematopoietic Stem Cells and Their Bone Marrow Microenvironment (2007) (419)
- The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells. (1998) (367)
- MicroRNA miR-125a controls hematopoietic stem cell number (2010) (325)
- Limiting factors in murine hematopoietic stem cell assays. (2007) (277)
- Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice. (2008) (248)
- Osteoblastic regulation of B lymphopoiesis is mediated by Gsα-dependent signaling pathways (2008) (231)
- Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML (2018) (217)
- RARγ is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation (2006) (175)
- T cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments (2016) (153)
- Deciphering hematopoietic stem cells in their niches: a critical appraisal of genetic models, lineage tracing, and imaging strategies. (2013) (142)
- All-trans retinoic acid enhances the long-term repopulating activity of cultured hematopoietic stem cells. (2000) (132)
- Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells (2005) (123)
- Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment. (2011) (117)
- All-trans retinoic acid delays the differentiation of primitive hematopoietic precursors (lin-c-kit+Sca-1(+)) while enhancing the terminal maturation of committed granulocyte/monocyte progenitors. (1999) (116)
- What is the true nature of the osteoblastic hematopoietic stem cell niche? (2009) (95)
- Myeloma plasma cells alter the bone marrow microenvironment by stimulating the proliferation of mesenchymal stromal cells (2014) (94)
- Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice. (2011) (90)
- Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias. (2008) (77)
- Generation and Analysis of Siah2 Mutant Mice (2003) (75)
- An oxysterol-binding protein family identified in the mouse. (2002) (63)
- Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA. (2013) (62)
- Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma cell death (2016) (58)
- Tug of war in the haematopoietic stem cell niche: do myeloma plasma cells compete for the HSC niche? (2012) (55)
- The role of vitamin A and retinoic acid receptor signaling in post-natal maintenance of bone (2016) (55)
- Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis. (2016) (42)
- PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells (2016) (40)
- Retinoic acid receptor signalling directly regulates osteoblast and adipocyte differentiation from mesenchymal progenitor cells (2017) (40)
- Identification of the molecular requirements for an RAR alpha-mediated cell cycle arrest during granulocytic differentiation. (2004) (38)
- Normal Human Peripheral Blood Mononuclear Cells Mobilized With Granulocyte Colony-Stimulating Factor Have Increased Osteoclastogenic Potential Compared To Nonmobilized Blood (1996) (37)
- Myelosuppressive Therapies Significantly Increase Pro‐Inflammatory Cytokines and Directly Cause Bone Loss (2015) (34)
- Multipotent hematopoietic cell lines derived from C/EBPalpha(-/-) knockout mice display granulocyte macrophage-colony-stimulating factor, granulocyte- colony-stimulating factor, and retinoic acid-induced granulocytic differentiation. (2001) (33)
- The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis. (2014) (32)
- Effects of the bone marrow microenvironment on hematopoietic malignancy. (2011) (31)
- The DNA Helicase Recql4 Is Required for Normal Osteoblast Expansion and Osteosarcoma Formation (2015) (31)
- EphB4 Expressing Stromal Cells Exhibit an Enhanced Capacity for Hematopoietic Stem Cell Maintenance (2015) (30)
- Srsf2P95H initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells. (2018) (28)
- Contrasting effects of P-selectin and E-selectin on the differentiation of murine hematopoietic progenitor cells. (2005) (28)
- RARγ is a negative regulator of osteoclastogenesis (2015) (26)
- Granulocyte Colony-Stimulating Factor and an RARα Specific Agonist, VTP195183, Synergize to Enhance the Mobilization of Hematopoietic Progenitor Cells (2007) (25)
- Wnt inhibitory factor 1 (WIF1) is a marker of osteoblastic differentiation stage and is not silenced by DNA methylation in osteosarcoma. (2015) (23)
- A novel population of cells expressing both hematopoietic and mesenchymal markers is present in the normal adult bone marrow and is augmented in a murine model of marrow fibrosis. (2012) (23)
- Osteoclasts eat stem cells out of house and home (2006) (20)
- Src family kinases and their role in hematological malignancies (2015) (20)
- Erythroid‐extrinsic regulation of normal erythropoiesis by retinoic acid receptors (2014) (19)
- Retinoic Acid Receptor γ Activity in Mesenchymal Stem Cells Regulates Endochondral Bone, Angiogenesis, and B Lymphopoiesis (2018) (19)
- Cell Division and Hematopoietic Stem Cells: Not Always Exhausting (2005) (18)
- ATRA and the specific RARα agonist, NRX195183, have opposing effects on the clonogenicity of pre-leukemic murine AML1-ETO bone marrow cells (2013) (16)
- All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia (2019) (16)
- Imaging methods used to study mouse and human HSC niches: Current and emerging technologies. (2019) (16)
- mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis (2018) (15)
- Mesenchymal lineage cells and their importance in B lymphocyte niches. (2017) (15)
- The characterization of distinct populations of murine skeletal cells that have different roles in B lymphopoiesis. (2021) (14)
- Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure (2015) (14)
- The haematopoietic stem cell niche: a new player in cardiovascular disease? (2019) (14)
- Faculty Opinions recommendation of miR-214 targets ATF4 to inhibit bone formation. (2013) (13)
- Retinoic Acid Receptor γ Regulates B and T Lymphopoiesis via Nestin-Expressing Cells in the Bone Marrow and Thymic Microenvironments (2016) (13)
- Osteopenia in Siah1a Mutant Mice* (2004) (13)
- Modeling human RNA spliceosome mutations in the mouse: not all mice were created equal. (2019) (12)
- The role of p202 in regulating hematopoietic cell proliferation and differentiation. (2008) (11)
- Roles of retinoids and retinoic Acid receptors in the regulation of hematopoietic stem cell self-renewal and differentiation. (2007) (10)
- Defining the hematopoietic stem cell niche: The chicken and the egg conundrum (2011) (10)
- The granulocyte‐colony stimulating factor receptor (G‐CSFR) interacts with retinoic acid receptors (RARs) in the regulation of myeloid differentiation (2013) (9)
- All-trans retinoic acid in non-promyelocytic acute myeloid leukemia: driver lesion dependent effects on leukemic stem cells (2020) (9)
- From the niche to malignant hematopoiesis and back: reciprocal interactions between leukemia and the bone marrow microenvironment (2021) (6)
- Protagonist or antagonist? The complex roles of retinoids in the regulation of hematopoietic stem cells and their specification from pluripotent stem cells. (2018) (6)
- Insights into myelodysplastic syndromes from current preclinical models (2016) (5)
- Arrested Hematopoiesis and Vascular Relaxation Defects in Mice with a Mutation in Dhfr (2016) (5)
- A population of nonneuronal GFRα3-expressing cells in the bone marrow resembles nonmyelinating Schwann cells (2019) (4)
- Loss of Parathyroid Hormone Receptor Signaling in Osteoprogenitors Is Associated With Accumulation of Multiple Hematopoietic Lineages in the Bone Marrow (2022) (3)
- Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly (2019) (3)
- The effects of chemotherapy agents used to treat pediatric acute lymphoblastic leukemia patients on bone parameters and longitudinal growth of juvenile mice. (2019) (3)
- "Human, mouse and dog bone marrow show similar mesenchymal stromal cells within a distinctive microenvironment". (2021) (2)
- Intravital Microscopy Reveals Fundamental Differences in the Interaction of Stem Cells and T Acute Lymphoblastic Leukaemia with the Bone Marrow Microenvironment (2016) (2)
- Gender inequities in medical research funding is driving an exodus of women from Australian STEMM academia (2022) (2)
- Regulation of murine B lymphopoiesis by stromal cells (2021) (2)
- Cell surface glucose-regulated protein 78 (GRP78) is upregulated in plasma cells of patients with multiple myeloma compared to monoclonal gammopathy of uncertain significance (2019) (1)
- ReviewArticle Roles of Retinoids and Retinoic Acid Receptors in the Regulation of Hematopoietic Stem Cell Self-Renewal and Differentiation (2007) (1)
- All-trans retinoic acid facilitates oncoretrovirus-mediated transduction of hematopoietic repopulating stem cells. (2001) (1)
- Taking HSCs down a Notch in leukemia. (2011) (1)
- Extrinsic Regulation of Hematopoietic Stem Cells and Lymphocytes by Vitamin A (2018) (1)
- The role of p202 in regulating hematopoietic cell proliferation and differentiation (Journal of Interferon and Cytokine Research 28, 1, (5-11)) (2008) (1)
- Higher Intensity of Cell Surface Glucose-Regulated Protein 78 (csGRP78) Expression Is Seen in Patients with Early Progressive Disease/Mortality in a Cohort of Relapsed, Refractory Multiple Myeloma Patients Treated with Carfilzomib, Thalidomide and Dexamethasone (2019) (1)
- A stressed niche not Wnted. (2011) (1)
- Parathyroid hormone receptor signaling in osteoprogenitors regulates erythropoiesis in the bone marrow and spleen (2016) (1)
- Novel Roles for the Homeobox Gene, HoxA1, and Its Truncated Form, HoxA1-T, in the Regulation of Hematopoietic Stem Cell Self-Renewal. (2004) (1)
- mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis (2018) (1)
- Myeloablative Therapies Damage and Alter the Composition of the Cells of the Bone Marrow Microenvironment. (2009) (0)
- Clonal Diversity As an Alternative Measure for Hematopoietic Reserve in Bone Marrow Failure (2022) (0)
- ATRA and the RARα Specific Agonist, NRX195183, Have Opposing Effects on the In Vitro Clonogenicity of Pre-Leukemic Murine AML1-ETO Bone Marrow Cells (2010) (0)
- SRSF2 P95h Mutation Promotes Myeloid Biased Hematopoiesis and Initiates Myeloproliferative/Myelodysplastic Syndromes From Hematopoietic Stem Cells (2018) (0)
- UNDERSTANDING THE BASIS OF CO-OPERATIVITY BETWEEN SRSF2P95H MUTATION AND TET2 DELETION IN A MOUSE MODEL OF MYELOPROLIFERATIVE/MYELODYSPLASTIC SYNDROMES (2019) (0)
- In memory of Paul Sylvain Frenette, a pioneering explorer of the hematopoietic stem cell niche who left far too early. (2021) (0)
- A High Salt Diet Accelerates Atherosclerosis By Modulating Hematopoiesis (2019) (0)
- The Truncated Form of Hoxa1 Regulates Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells. (2009) (0)
- The polarity protein, PAR3, is a key regulator of haematopoietic progenitors (2015) (0)
- The Cell Polarity and Scaffolding Protein, PAR3, Acts as A Tumour Suppressor in Acute Myeloid Leukemia Through Regulation of the Hippo Pathway (2018) (0)
- Abstract LB-183: Investigating the role of polarity protein, SCRIB, in hematopoiesis (2018) (0)
- PDGF-AB and azacitidine induced reprogramming of somatic cells into tissue regenerative multipotent stem cells (2015) (0)
- 1006 - KEY ROLES OF HOXA1 IN HSCS AND MYELODYSPLASTIC SYNDROMES (2019) (0)
- Identification and Analysis of Oncogenic Pathways in Deletion 20q Acute Myeloid Leukaemia (2012) (0)
- Retinoic acid receptor γ regulates lymphopoiesis via nestin+ bone marrow and thymic microenvironment cells (2014) (0)
- A population of nonneuronal GFRα3-expressing cells in the bone marrow resembles nonmyelinating Schwann cells (2019) (0)
- Microenvironments the Bone Marrow and Thymic inLymphopoiesis via Nestin-Expressing Cells Regulates B and T γ Retinoic Acid Receptor Maluenda (2016) (0)
- Adult murine hematopoietic stem cells and progenitors: an update on their identities, functions and assays. (2022) (0)
- Faculty Opinions recommendation of Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network. (2010) (0)
- Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly (2019) (0)
- All-trans retinoic acid enhances the production of serially transplantable hematopoffitic stem cells in ex vivo liquid suspension culture (2000) (0)
- Dysregulated expression of Hoxa1 isoforms in hematopoietic stem and progenitor cells causes myelodysplastic syndromes (2023) (0)
- Faculty Opinions recommendation of Endothelial and perivascular cells maintain haematopoietic stem cells. (2012) (0)
- Identifying epigenetic targets in osteosarcoma and differentiating osteoblasts (2010) (0)
- Scribble impacts on thymocyte numbers in vivo (2016) (0)
- P-074: Assessing the immune microenvironment with multiplex immunofluorescence histochemistry demonstrates proximity of cytotoxic T-cells to plasma cells in patients with newly diagnosed multiple myeloma (2021) (0)
- Sugar Rush: Supercharging Blood Cell Specification via the Inflammasome. (2020) (0)
- RETINOIC ACID RECEPTOR GAMMA ACTIVITY IN ENDOTHELIAL CELLS REGULATES B LYMPHOPOIESIS, ERYTHROPOIESIS, PLATELET PRODUCTION, VASCULATURE STRUCTURE AND ADIPOCYTE SIZE IN A SEX-DEPENDENT MANNER (2019) (0)
- Faculty Opinions recommendation of Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells. (2011) (0)
- Key Roles of Hoxa1 in Myelodysplastic Syndromes (2019) (0)
- Extrinsic Regulation of Hematopoietic Stem Cells and Lymphocytes by Vitamin A (2018) (0)
- Cytotoxic therapies cause irreversible damage to the niches for multipotent progenitor cells, resulting in impaired long-term repopulating potential of bone marrow (2015) (0)
- 2021 - CHOLINERGIC INFLUENCE OF BONE MARROW VASCULAR MICROENVIRONMENT INFLUENCES HEMATOPOIETIC STEM CELL MOBILIZATION (2019) (0)
- The Role of Retinoic Acid Receptors in Myeloid Differentiation (2002) (0)
- Modeling Myelodysplastic Syndromes In Mice By Altered Hoxa1 Spliceform Expression (2013) (0)
- Deregulated Hoxa1 Expression in Murine Bone Marrow Results in An MDS-Like Phenotype (2011) (0)
- IN SITU CHARACTERIZATION OF THE HEMATOPOIETIC STEM AND PROGENITOR CELL MICROENVIRONMENT WITH FLUORESCENCE MULTIPLEXING AND SPECTRAL UNMIXING (2019) (0)
- Faculty Opinions recommendation of Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration. (2012) (0)
- THE EFFECTS OF CHEMOTHERAPY AGENTS USED TO TREAT PAEDIATRIC ACUTE LYMPHOBLASTIC LEUKAEMIA ON BONE PARAMETERS AND LONGITUDINAL GROWTH OF JUVENILE MICE (2019) (0)
- Altered Expression of Hoxa1 Perturbs Haematopoiesis in a Dose-Dependent Manner and Induces Myelodysplasia in Mice (2016) (0)
- Altered Expression of Hoxa1 Perturbs Normal Haematopoiesis, Depletes Haematopoietic Stem Cells, and is Sufficient to Induce Myelodysplasia in Mice (2017) (0)
- Role of the polarity protein, scribble, in hematopoiesis and leukemia (2014) (0)
- A Mouse Model Of Rothmund-Thomson Syndrome Reveals An Essential Role For Recql4 In Maintenance Of Hematopoiesis (2013) (0)
- Investigating the role of polarity protein, SCRIB, in haematopoiesis (2017) (0)
- 1030 – THE REGULATION OF HEMATOPOIESIS BY VITAMIN A: A TUG OF WAR. (2022) (0)
- 3208 – PROLONGED THROMBOCYTOPENIA IN BONE MARROW TRANSPLANT PATIENTS IS CAUSED BY IMPAIRED SUPPORT OF PLATELET PRECURSOR CELLS BY ALTERED BONE MARROW NICHES (2022) (0)
- Author response for "From the Niche to Malignant Hematopoiesis and Back: Reciprocal Interactions between Leukemia and the Bone Marrow Microenvironment" (2021) (0)
- In memoriam: Graham Molineux (1957–2013) (2014) (0)
- Assessing the Immune Tumour Microenvironment (iTME) Using Multiplex Immunoflourescence Histochemistry (mIHC) Demonstrates Close Proximity of Cytotoxic T-Cells to Plasma Cells (PC) in Patients with Newly Diagnosed Multiple Myeloma (NDMM) (2021) (0)
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