Lourdes J. Cruz
Filipino biochemist
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Biology
Lourdes J. Cruz's Degrees
- PhD Biochemistry University of the Philippines
- Masters Biochemistry University of the Philippines
- Bachelors Chemistry University of the Philippines
Why Is Lourdes J. Cruz Influential?
(Suggest an Edit or Addition)According to Wikipedia, Lourdes J. Cruz is a Filipino biochemist whose research has contributed to the understanding of the biochemistry of toxic peptides from the venom of fish-hunting Conus marine snails. Throughout the Philippines, she is known as the Sea Snail Venom Specialist. The characterization of over 50 biologically active peptides from the snail's venom had been made possible, in part, by her studies. Scientific findings regarding the peptides found in snails have applications in diagnostic tools for cancers and the development of drugs for the treatment of neurological disorders. She has also contributed to the development of conotoxins as tools for examining the activity of the human brain. Her contributions to science have earned her several awards and acknowledgements including being named a National Scientist of the Philippines in 2006.
Lourdes J. Cruz's Published Works
Published Works
- Omega-conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle. (1987) (761)
- Peptide neurotoxins from fish-hunting cone snails. (1985) (702)
- Diversity of Conus neuropeptides. (1990) (529)
- A new conus peptide ligand for mammalian presynaptic Ca2+ channels (1992) (490)
- Purification and sequence of a presynaptic peptide toxin from Conus geographus venom. (1984) (398)
- Conus geographus toxins that discriminate between neuronal and muscle sodium channels. (1985) (376)
- Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom. (1987) (320)
- Conotoxins, in retrospect. (2001) (234)
- Peptide toxins from venomous Conus snails. (1988) (219)
- Peptide toxins from Conus geographus venom. (1981) (219)
- Calcium channel antagonists. Omega-conotoxin defines a new high affinity site. (1986) (209)
- Invertebrate vasopressin/oxytocin homologs. Characterization of peptides from Conus geographus and Conus straitus venoms. (1987) (202)
- Isolation and structure of a peptide toxin from the marine snail Conus magus. (1982) (170)
- Contulakin-G, an O-Glycosylated Invertebrate Neurotensin* (1999) (168)
- Gamma-carboxyglutamate in a neuroactive toxin. (1984) (162)
- Studies on the extraction and composition of rice proteins. (1966) (161)
- Constant and hypervariable regions in conotoxin propeptides. (1990) (157)
- Venomous cone snails: molecular phylogeny and the generation of toxin diversity. (2001) (146)
- Conus Peptides as Chemical Probes for Receptors and Ion Channels (1993) (143)
- Characterization of the omega-conotoxin target. Evidence for tissue-specific heterogeneity in calcium channel types. (1987) (141)
- μ-Conotoxin PIIIA, a New Peptide for Discriminating among Tetrodotoxin-Sensitive Na Channel Subtypes (1998) (136)
- Contryphan Is a D-Tryptophan-containing Conus Peptide* (1996) (126)
- Conantokin-T. A gamma-carboxyglutamate containing peptide with N-methyl-d-aspartate antagonist activity. (1990) (125)
- A New Family of Conus Peptides Targeted to the Nicotinic Acetylcholine Receptor (*) (1995) (121)
- The T-superfamily of Conotoxins* (1999) (118)
- Bromocontryphan: post-translational bromination of tryptophan. (1997) (111)
- Neuronal calcium channel inhibitors. Synthesis of omega-conotoxin GVIA and effects on 45Ca uptake by synaptosomes. (1987) (111)
- The A-superfamily of Conotoxins (2004) (101)
- An O-glycosylated neuroexcitatory conus peptide. (1998) (92)
- A molluscivorous Conus toxin: conserved frameworks in conotoxins. (1989) (91)
- Phylogenetic specificity of cholinergic ligands: alpha-conotoxin SI. (1988) (90)
- Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms. (2005) (89)
- A Novel Post-translational Modification Involving Bromination of Tryptophan (1997) (89)
- Novel excitatory Conus peptides define a new conotoxin superfamily (2003) (89)
- Delta-conotoxin GmVIA, a novel peptide from the venom of Conus gloriamaris. (1994) (86)
- Conantokin-G: A novel peptide antagonist to the N-methyl-d-aspartic acid (NMDA) receptor (1990) (86)
- alpha-Conotoxins, small peptide probes of nicotinic acetylcholine receptors. (1991) (83)
- Isolation and Characterization of a Novel ConusPeptide with Apparent Antinociceptive Activity* (2000) (83)
- Conotoxin MI. Disulfide bonding and conformational states. (1983) (77)
- The contryphans, a D-tryptophan-containing family of Conus peptides: interconversion between conformers. (2009) (75)
- Proteomic analysis provides insights on venom processing in Conus textile. (2010) (72)
- In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. (2000) (71)
- Purification and properties of a myotoxin from Conus geographus venom. (1978) (71)
- Conus peptides as probes for ion channels. (1999) (68)
- The spasmodic peptide defines a new conotoxin superfamily. (2000) (64)
- Transmitter release from presynaptic terminals of electric organ: inhibition by the calcium channel antagonist omega Conus toxin (1987) (63)
- A novel D-leucine-containing Conus peptide: diverse conformational dynamics in the contryphan family. (1999) (60)
- Biochemical factors affecting protein accumulation in the rice grain. (1970) (60)
- mu-conotoxin GIIIA, a peptide ligand for muscle sodium channels: chemical synthesis, radiolabeling, and receptor characterization. (1989) (59)
- Microcionamides A and B, bioactive peptides from the philippine sponge Clathria (Thalysias) abietina. (2004) (57)
- Contryphans from Conus textile venom ducts. (2001) (55)
- Total synthesis and further characterization of the gamma-carboxyglutamate-containing "sleeper" peptide from Conus geographus venom. (1987) (52)
- Conantokin-L, a new NMDA receptor antagonist: determinants for anticonvulsant potency (2002) (50)
- Conus venoms: a rich source of neuroactive peptides (1985) (50)
- The pyridine nucleotide cycle. Studies in Escherichia coli and the human cell line D98/AH2. (1981) (48)
- A toxin from the venom of the marine snail Conus geographus which acts on the vertebrate central nervous system. (1981) (47)
- Effects of Conus peptides on the behavior of mice (1999) (47)
- Agelasine F from a Philippine Agelas sp. sponge exhibits in vitro antituberculosis activity. (2000) (46)
- A sleep-inducing peptide from Conus geographus venom. (1985) (43)
- Chemical fingerprinting and phylogenetic mapping of saponin congeners from three tropical holothurian sea cucumbers. (2013) (40)
- A PRELIMINARY STUDY OF CONUS VENOM PROTEIN (1976) (35)
- Constrained de novo sequencing of conotoxins. (2012) (31)
- Calcium Channel‐Targeted Polypeptide Toxins a (1991) (28)
- The augertoxins: biochemical characterization of venom components from the toxoglossate gastropod Terebra subulata. (2003) (27)
- Conus Peptides: Phylogenetic Range of Biological Activity. (1992) (26)
- Peptides from Conus Venoms which Affect Ca++ Entry into Neurons (1990) (25)
- Carboxyglutamate in a Neuroactive Toxin (24)
- Optimization of low-cost drying methods to minimize lipid peroxidation in Spirulina platensis grown in the Philippines (2007) (22)
- Preliminary studies in some aspects of amino acid biosynthesis in juveniles of Penaeus monodon Fabricius: I. Incorporation of 14C from (U-14C) acetate into amino acids to precipitable proteins. (1980) (16)
- Structural and biosynthetic properties of peptides in cone snail venoms (1995) (12)
- Conophysin-R, a Conus radiatus venom peptide belonging to the neurophysin family. (2002) (12)
- Chapter 20 ω-Conotoxins and Voltage-Sensitive Calcium Channel Subtypes (1988) (12)
- Conotoxins : targeted peptide ligands from snail venoms (1990) (11)
- Detection of ciguatera fish poisoning in the Philippines (2013) (10)
- Paralytic shellfish toxin concentration and cell density changes in Pyrodinium bahamense -Noctiluca scintillans feeding experiments. (2010) (9)
- Clinical Toxicology of Conus Snail Stings (2017) (9)
- Determination of shelf life of Spirulina platensis (MI2) grown in the Philippines (2007) (7)
- Primary structural motifs of Conus peptides. (1996) (6)
- Constrained De Novo Sequencing of Peptides with Application to Conotoxins (2011) (6)
- Localization of enzymes and possible toxin precursors in granules from Conus striatus venom (1983) (4)
- A Modified Procedure for the Preparation of Mitoxantrone (2006) (4)
- Toxicity and Protein Expression of Alexandrium Species Collected in the Philippine Waters (2017) (4)
- Incomplete inversion of D-leucine and D-valine. (1970) (4)
- Conus Peptides and Their Iodinated Derivatives as Probes for Ion Channels and Receptors (2000) (3)
- Muscle-relaxing peptides from conus venoms (1977) (3)
- Conotoxins as Tools in Research on Nicotinic Receptors (2017) (2)
- Effect of bioactive compounds extracted from Cordyceps nidus ANDES-F1080 on laccase activity of Pleurotus ostreatus ANDES-F515 (2020) (2)
- Mutual antagonism in the metabolism of D-valine and D-leucine and antagonism by their analogs. (1969) (2)
- Potential of a Forestry Carbon Project for the Magbukun Ayta of Bataan, Philippines (2018) (2)
- Post-translational modification: A two-dimensional strategy for molecular diversity of Conus peptides (2002) (2)
- Toxins and Drug Discovery (2017) (1)
- Conus Peptides and Biotechnology (1992) (1)
- CONOTOXINS: BIOCHEMICAL PROBES FOR ION CHANNELS AND RECEPTORS (1989) (1)
- Quantitative assay for Conus toxin. (1977) (1)
- A tyrosine-containing analog of mu-conotoxin GIIIA as ligand in the receptor binding assay for paralytic shellfish poisons. (2015) (1)
- Erratum: The T-superfamily of conotoxins (Journal of Biological Chemistry (1999) (30664-30671)) (1999) (1)
- Can Carbon Forestry Provide a Solution for Community-led Conservation? A Case from the Philippines (2016) (0)
- Peptide toxins from venoms as pharmacological agents: conotoxins as examples (1990) (0)
- Contulaquina-g, analogues thereof and uses thereof. (1999) (0)
- The interaction of conotoxins with receptors and ion channels (1995) (0)
- Factors affecting the inversion and utilization of D-leucine and D-valine for growth. (1969) (0)
- Corrigendum to “Chemical fingerprinting and phylogenetic mapping of saponin congeners from three tropical holothurian sea cucumbers” [Comp. Biochem. Physiol. B 166 (3–4) (2013) 182–193] (2014) (0)
- Optimization of low-cost drying methods to minimize lipid peroxidation and determination of shelf life of Spirulina platensis (MI2) (Cyanobacteria) grown in the Philippines (2006) (0)
- In Vitro and In Vivo Characterization of Conantokin-R , a Selective NMDA Receptor Antagonist Isolated from the Venom of the Fish-Hunting Snail Conus radiatus 1 (1999) (0)
- Calcium Channel Antagonists (2001) (0)
- National Scientist Lourdes Jansuy Cruz : From Rice to Conus Research — the Journey by Evelyn Mae Tecson-Mendoza (2010) (0)
- Table of Contents (1990) (0)
- Selection of Suitable Anti-rHBsAg Mabs for in vitro Production (2001) (0)
- In vivo activities of conantokin-G analogs (1994) (0)
- Erratum: Conophysin-R, a Conus radiatus venom peptide belonging to the neurophysin family (Toxicon (2002) 40:7 (901-908) PII: S004101010200079X) (2003) (0)
- Preliminary studies in some aspects of amino acid biosynthesis in juveniles of Penaeus monodon Fabricius: II. Partial purification and characterization of muscle L-glutamate dehydrogenase (1980) (0)
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