Luiz Belardinelli

Luiz Belardinelli's AcademicInfluence.com Rankings

Luiz Belardinelli

Medical

#1635

World Rank

#1996

Historical Rank

Cardiology

#129

World Rank

#132

Historical Rank

medical Degrees

Luiz Belardinelli

Engineering

#3454

World Rank

#4535

Historical Rank

Biomedical Engineering

#165

World Rank

#170

Historical Rank

engineering Degrees

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Medical
Engineering

Luiz Belardinelli's Degrees

PhD Biomedical Engineering Stanford University
Masters Biomedical Engineering Stanford University
Bachelors Biomedical Engineering Stanford University

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Luiz Belardinelli's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The cardiac effects of adenosine. (1989) (798)
Electrophysiological Effects of Ranolazine, a Novel Antianginal Agent With Antiarrhythmic Properties (2004) (659)
Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology. (1997) (571)
Adenosine-sensitive ventricular tachycardia: evidence suggesting cyclic AMP-mediated triggered activity. (1986) (464)
Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine (2006) (376)
Cardiac Electrophysiology of Adenosine: Basic and Clinical Concepts (1991) (368)
Adenosine: electrophysiologic effects and therapeutic use for terminating paroxysmal supraventricular tachycardia. (1983) (365)
Late Sodium Current Inhibition Reverses Electromechanical Dysfunction in Human Hypertrophic Cardiomyopathy (2013) (332)
Adenosine versus regadenoson comparative evaluation in myocardial perfusion imaging: Results of the ADVANCE phase 3 multicenter international trial (2007) (323)
Atrium-Selective Sodium Channel Block as a Strategy for Suppression of Atrial Fibrillation: Differences in Sodium Channel Inactivation Between Atria and Ventricles and the Role of Ranolazine (2007) (316)
Diagnostic and therapeutic use of adenosine in patients with supraventricular tachyarrhythmias. (1985) (298)
Isolated atrial myocytes: adenosine and acetylcholine increase potassium conductance. (1983) (298)
Assessing predictors of drug-induced torsade de pointes. (2003) (295)
Differential Expression of Adenosine Receptors in Human Endothelial Cells: Role of A2B Receptors in Angiogenic Factor Regulation (2002) (276)
Ionic basis of the electrophysiological actions of adenosine on cardiomyocytes (1995) (274)
Reactive Oxygen Species–Activated Ca/Calmodulin Kinase II&dgr; Is Required for Late INa Augmentation Leading to Cellular Na and Ca Overload (2011) (271)
Blocking Late Sodium Current Reduces Hydrogen Peroxide-Induced Arrhythmogenic Activity and Contractile Dysfunction (2006) (269)
Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation. (2008) (268)
Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury. (2006) (255)
Ranolazine Improves Abnormal Repolarization and Contraction in Left Ventricular Myocytes of Dogs with Heart Failure by Inhibiting Late Sodium Current (2006) (252)
Altered Na(+) currents in atrial fibrillation effects of ranolazine on arrhythmias and contractility in human atrial myocardium. (2010) (251)
Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome. (2014) (222)
Actions of Adenosine and Isoproterenol on Isolated Mammalian Ventricular Myocytes (1983) (222)
Antagonism by Ranolazine of the Pro-Arrhythmic Effects of Increasing Late INa in Guinea Pig Ventricular Myocytes (2004) (209)
Electrophysiologic basis for the antiarrhythmic actions of ranolazine. (2011) (208)
A2A-adenosine receptor reserve for coronary vasodilation. (1998) (192)
Evaluation of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina: results from the TERISA randomized clinical trial (Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina). (2013) (191)
Antiarrhythmic Effects of Ranolazine in a Guinea Pig in Vitro Model of Long-QT Syndrome (2004) (186)
The A2A adenosine receptor mediates coronary vasodilation. (1998) (184)
Pathophysiology and pharmacology of the cardiac "late sodium current.". (2008) (179)
Ionic mechanisms of adenosine actions in pacemaker cells from rabbit heart. (1988) (175)
RAnoLazIne for the treatment of diastolic heart failure in patients with preserved ejection fraction: the RALI-DHF proof-of-concept study. (2013) (170)
Adenosine receptor activation induces vascular endothelial growth factor in human retinal endothelial cells. (1999) (170)
A Novel, Potent, and Selective Inhibitor of Cardiac Late Sodium Current Suppresses Experimental Arrhythmias (2012) (168)
Ranolazine Improves Cardiac Diastolic Dysfunction Through Modulation of Myofilament Calcium Sensitivity (2010) (162)
Ionic Basis for the Antagonism between Adenosine and Isoproterenol on Isolated Mammalian Ventricular Myocytes (1984) (157)
An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes. (2008) (156)
Differential Effects of Adenosine and Nitroglycerin on the Action Potentials of Large and Small Coronary Arteries (1979) (156)
Extracellular Action of Adenosine and the Antagonism by Aminophylline on the Atrioventricular Conduction of Isolated Perfused Guinea Pig and Rat Hearts (1982) (153)
Synergy between A2B adenosine receptors and hypoxia in activating human lung fibroblasts. (2005) (149)
Late sodium current inhibition as a new cardioprotective approach. (2008) (148)
Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts. (2006) (140)
Effect of Adenosine on Atrioventricular Conduction. I: Site and Characterization of Adenosine Action in the Guinea Pig Atrioventricular Node (1986) (137)
A2B Adenosine Receptors Increase Cytokine Release by Bronchial Smooth Muscle Cells (2004) (135)
Proliferation, migration, and ERK activation in human retinal endothelial cells through A(2B) adenosine receptor stimulation. (2001) (135)
The HARMONY Trial: Combined Ranolazine and Dronedarone in the Management of Paroxysmal Atrial Fibrillation Mechanistic and Therapeutic Synergism (2015) (135)
Adenosine A2A Receptors Mediate Coronary Microvascular Dilation to Adenosine: Role of Nitric Oxide and ATP-Sensitive Potassium Channels (1999) (130)
The role of late I Na in development of cardiac arrhythmias. (2014) (128)
Pharmacology and therapeutic applications of A1 adenosine receptor ligands. (2003) (125)
Electrophysiologic Properties and Antiarrhythmic Actions of a Novel Antianginal Agent (2004) (125)
Natriuretic and diuretic actions of a highly selective adenosine A1 receptor antagonist. (1999) (124)
Alterations in Adenosine Metabolism and Signaling in Patients with Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis (2010) (124)
Regadenoson, a selective A2A adenosine receptor agonist, causes dose-dependent increases in coronary blood flow velocity in humans (2007) (123)
Cisapride-Induced Transmural Dispersion of Repolarization and Torsade de Pointes in the Canine Left Ventricular Wedge Preparation During Epicardial Stimulation (2003) (120)
Antiarrhythmic effects of ranolazine in canine pulmonary vein sleeve preparations. (2008) (119)
Novel short-acting A2A adenosine receptor agonists for coronary vasodilation: inverse relationship between affinity and duration of action of A2A agonists. (2001) (118)
Thioredoxin-2 Inhibits Mitochondrial Reactive Oxygen Species Generation and Apoptosis Stress Kinase-1 Activity to Maintain Cardiac Function (2015) (117)
Cardiac late Na⁺ current: proarrhythmic effects, roles in long QT syndromes, and pathological relationship to CaMKII and oxidative stress. (2015) (116)
The arrhythmogenic consequences of increasing late INa in the cardiomyocyte. (2013) (113)
Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology (2012) (111)
Caffeine alters A2A adenosine receptors and their function in human platelets. (1999) (109)
Relationship Between Nonsustained Ventricular Tachycardia After Non–ST-Elevation Acute Coronary Syndrome and Sudden Cardiac Death: Observations From the Metabolic Efficiency With Ranolazine for Less Ischemia in Non–ST-Elevation Acute Coronary Syndrome–Thrombolysis in Myocardial Infarction 36 (MERLIN (2010) (108)
Atrioventricular Conduction Disturbances during Hypoxia: Possible Role of Adenosine in Rabbit and Guinea Pig Heart (1980) (106)
Ranolazine Exerts Potent Effects on Atrial Electrical Properties and Abbreviates Atrial Fibrillation Duration in the Intact Porcine Heart (2009) (105)
Tachycardia Caused by A2A Adenosine Receptor Agonists Is Mediated by Direct Sympathoexcitation in Awake Rats (2006) (104)
Ranolazine: Ion‐channel‐blocking actions and in vivo electrophysiological effects (2004) (103)
Late Sodium Current Contributes to the Reverse Rate-Dependent Effect of IKr Inhibition on Ventricular Repolarization (2011) (103)
Adenosine-sensitive afterdepolarizations and triggered activity in guinea pig ventricular myocytes. (1992) (101)
Effect of a Specific and Selective A2B Adenosine Receptor Antagonist on Adenosine Agonist AMP and Allergen-Induced Airway Responsiveness and Cellular Influx in a Mouse Model of Asthma (2007) (98)
Synergistic effect of the combination of ranolazine and dronedarone to suppress atrial fibrillation. (2010) (97)
Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice. (2011) (96)
Mechanism of atropine-resistant atrioventricular block during inferior myocardial infarction: possible role of adenosine. (1986) (96)
Inhibition of late (sustained/persistent) sodium current: a potential drug target to reduce intracellular sodium-dependent calcium overload and its detrimental effects on cardiomyocyte function (2004) (95)
Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure. (2008) (95)
An Increase in Late Sodium Current Potentiates the Proarrhythmic Activities of Low-Risk QT-Prolonging Drugs in Female Rabbit Hearts (2006) (94)
Effect of adenosine and adenosine-5'-triphosphate on atrioventricular conduction in patients. (1985) (94)
Inflammatory agents regulate in vivo expression of fractalkine in endothelial cells of the rat heart (1999) (92)
Dose and time effects of caffeine intake on human platelet adenosine A(2A) receptors : functional and biochemical aspects. (2000) (92)
Canine Myocardial Adenosine and Lactate Production, Oxygen Consumption, and Coronary Blood Flow during Stellate Ganglia Stimulation (1979) (92)
Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease. (2013) (91)
Cellular basis for the electrocardiographic and arrhythmic manifestations of Timothy syndrome: effects of ranolazine. (2007) (91)
Late na(+) current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model. (2010) (90)
Late sodium current contributes to diastolic cell Ca2+ accumulation in chronic heart failure (2010) (90)
The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease (2012) (88)
Effects of adenosine on atrial refractoriness and arrhythmias. (1994) (87)
Cardiac electrophysiology and pharmacology of adenosine: basic and clinical aspects. (1993) (87)
The Role of Sodium Channel Current in Modulating Transmural Dispersion of Repolarization and Arrhythmogenesis (2006) (87)
Inverse agonists and neutral antagonists of recombinant human A1 adenosine receptors stably expressed in Chinese hamster ovary cells. (1998) (86)
Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine. (2008) (85)
A2B Adenosine Receptors Induce IL-19 from Bronchial Epithelial Cells, Resulting in TNF-α Increase (2006) (84)
A1 adenosine receptor: role in diabetes and obesity. (2009) (83)
The mechanism of ranolazine action to reduce ischemia-induced diastolic dysfunction (2006) (83)
Use-dependent block of cardiac late Na(+) current by ranolazine. (2009) (82)
Synergistic Electrophysiologic and Antiarrhythmic Effects of the Combination of Ranolazine and Chronic Amiodarone in Canine Atria (2010) (81)
Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967. (2013) (79)
Antiadrenergic effects of adenosine on His-Purkinje automaticity. Evidence for accentuated antagonism. (1988) (79)
Efficacy of Ranolazine in Patients With Symptomatic Hypertrophic Cardiomyopathy: The RESTYLE-HCM Randomized, Double-Blind, Placebo-Controlled Study (2018) (78)
Characterization of the potency, selectivity, and pharmacokinetic profile for six adenosine A2A receptor antagonists (2007) (78)
Effect of Ranolazine on A1C and Glucose Levels in Hyperglycemic Patients With Non-ST Elevation Acute Coronary Syndrome (2010) (77)
Comparison of the Seattle Angina Questionnaire With Daily Angina Diary in the TERISA Clinical Trial (2014) (77)
Ranolazine, an antianginal agent, markedly reduces ventricular arrhythmias induced by ischemia and ischemia-reperfusion. (2009) (76)
Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone. (2008) (74)
Effects of adenosine and adenine nucleotides on the atrioventricular node of isolated guinea pig hearts. (1984) (73)
Evidence for adenosine mediation of atrioventricular block in the ischemic canine myocardium. (1981) (72)
Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure (2012) (72)
A Population Pharmacokinetic/Pharmacodynamic Analysis of Regadenoson, an Adenosine A2A-Receptor Agonist, in Healthy Male Volunteers (2006) (71)
Ranolazine Prevents Phenotype Development in a Mouse Model of Hypertrophic Cardiomyopathy (2017) (71)
Chronotropic and Dromotropic Effects of Adenosine (1983) (71)
Atrial‐Selective Sodium Channel Block as a Strategy for Suppression of Atrial Fibrillation (2008) (70)
Inhibition of human mast cell activation with the novel selective adenosine A(2B) receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)(2). (2001) (70)
Bradycardia after heart transplantation: reversal with theophylline. (1996) (67)
Differential A1 adenosine receptor reserve for two actions of adenosine on guinea pig atrial myocytes. (1997) (65)
Complex electrophysiological remodeling in postinfarction ischemic heart failure (2018) (64)
A Comparison between Ranolazine and CVT-4325, a Novel Inhibitor of Fatty Acid Oxidation, on Cardiac Metabolism and Left Ventricular Function in Rat Isolated Perfused Heart during Ischemia and Reperfusion (2007) (64)
A1 adenosine receptor partial agonist lowers plasma FFA and improves insulin resistance induced by high-fat diet in rodents. (2007) (63)
If inhibition in the atrioventricular node by ivabradine causes rate-dependent slowing of conduction and reduces ventricular rate during atrial fibrillation. (2014) (62)
Selective A2A Adenosine Receptor Agonist as a Coronary Vasodilator in Conscious Dogs: Potential for Use in Myocardial Perfusion Imaging (2003) (61)
A study of the effects of ranolazine using automated quantitative analysis of serial myocardial perfusion images. (2009) (60)
Calmodulin kinase II and protein kinase C mediate the effect of increased intracellular calcium to augment late sodium current in rabbit ventricular myocytes. (2012) (60)
Mechanisms of atrial-selective block of Na⁺ channels by ranolazine: I. Experimental analysis of the use-dependent block. (2011) (59)
Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium (2008) (59)
Antagonism of forskolin effects by adenosine in isolated hearts and ventricular myocytes. (1986) (58)
Species-dependent effects of adenosine on heart rate and atrioventricular nodal conduction. Mechanism and physiological implications. (1990) (58)
Reduction of repolarization reserve unmasks the proarrhythmic role of endogenous late Na(+) current in the heart. (2009) (58)
Na+ channel function, regulation, structure, trafficking and sequestration (2015) (57)
Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII (2015) (57)
Rapid Kinetic Interactions of Ranolazine With HERG K+ Current (2008) (56)
Comparative Profile of Vasodilation by CVT-3146, a Novel A2A Receptor Agonist, and Adenosine in Conscious Dogs (2003) (55)
GS-6201, a Selective Blocker of the A2B Adenosine Receptor, Attenuates Cardiac Remodeling after Acute Myocardial Infarction in the Mouse (2012) (55)
Adenosine A2B receptor and hyaluronan modulate pulmonary hypertension associated with chronic obstructive pulmonary disease. (2013) (55)
Ranolazine Increases β-Cell Survival and Improves Glucose Homeostasis in Low-Dose Streptozotocin-Induced Diabetes in Mice (2011) (55)
Differences in heart rate response to adenosine and regadenoson in patients with and without diabetes mellitus. (2009) (54)
Mechanisms of ranolazine's dual protection against atrial and ventricular fibrillation (2012) (54)
Ranolazine for the Treatment of Heart Failure With Preserved Ejection Fraction: Background, Aims, and Design of the RALI‐DHF Study (2011) (54)
Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine. (1997) (54)
A2B adenosine receptors induce IL-19 from bronchial epithelial cells, resulting in TNF-alpha increase. (2006) (53)
Electrophysiologic effects of dipyridamole on atrioventricular nodal conduction and supraventricular tachycardia. Role of endogenous adenosine. (1989) (53)
Block of Tetrodotoxin-sensitive, Nav1.7, and Tetrodotoxin-resistant, Nav1.8, Na+ channels by Ranolazine (2008) (53)
Theophylline for the Treatment of Atrioventricular Block after Myocardial Infarction (1995) (52)
Enhanced Sensitivity of Heart Cells to Adenosine and Up-Regulation of Receptor Number After Treatment of Guinea Pigs With Theophylline (1989) (52)
Plasma adenosine and hypoxemia in patients with sleep apnea. (1988) (52)
A(2B) adenosine receptors increase cytokine release by bronchial smooth muscle cells. (2004) (50)
Antagonism of the effects of adenosine and hypoxia on atrioventricular conduction time by two novel alkylxanthines: correlation with binding to adenosine A1 receptors. (1987) (49)
Atrioventricular nodal accommodation in isolated guinea pig hearts: physiological significance and role of adenosine. (1988) (49)
Binding of the novel nonxanthine A2A adenosine receptor antagonist [3H]SCH58261 to coronary artery membranes. (1996) (48)
β-adrenergic regulation of late Na+ current during cardiac action potential is mediated by both PKA and CaMKII. (2018) (48)
Synergistic Effect of the Combination of Dronedarone and Ranolazine to Suppress Atrial Fibrillation (2010) (47)
Electrophysiological and receptor binding studies to assess activation of the cardiac adenosine receptor by adenine nucleotides. (1991) (47)
Novel Approach Targeting the Complex Pathophysiology of Hypertrophic Cardiomyopathy: The Impact of Late Sodium Current Inhibition on Exercise Capacity in Subjects with Symptomatic Hypertrophic Cardiomyopathy (LIBERTY-HCM) Trial (2016) (47)
Intracellular Na+ overload causes oxidation of CaMKII and leads to Ca2+ mishandling in isolated ventricular myocytes. (2014) (47)
Effect of ranolazine on atrial fibrillation in patients with non-ST elevation acute coronary syndromes: observations from the MERLIN-TIMI 36 trial. (2015) (47)
Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts. (2014) (46)
Antifibrillatory effect of ranolazine during severe coronary stenosis in the intact porcine model. (2011) (46)
Late sodium current inhibitors to treat exercise‐induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium (2018) (46)
Allosteric enhancer PD 81,723 acts by novel mechanism to potentiate cardiac actions of adenosine. (1994) (46)
Low doses of ranolazine and dronedarone in combination exert potent protection against atrial fibrillation and vulnerability to ventricular arrhythmias during acute myocardial ischemia. (2013) (46)
Antilipolytic Activity of a Novel Partial A1 Adenosine Receptor Agonist Devoid of Cardiovascular Effects: Comparison with Nicotinic Acid (2007) (46)
Effects of dipyridamole and aminophylline on hemodynamics, regional myocardial blood flow and thallium-201 washout in the setting of a critical coronary stenosis. (1990) (45)
Ranolazine for Congenital Long-QT Syndrome Type III: Experimental and Long-Term Clinical Data (2016) (45)
Ranolazine Antagonizes the Effects of Increased Late Sodium Current on Intracellular Calcium Cycling in Rat Isolated Intact Heart (2009) (45)
Blockade of Na+ Channels in Pancreatic α-Cells Has Antidiabetic Effects (2014) (44)
Deranged sodium to sudden death (2015) (44)
Early somatic mosaicism is a rare cause of long-QT syndrome (2016) (44)
Agonist-independent effect of an allosteric enhancer of the A1 adenosine receptor in CHO cells stably expressing the recombinant human A1 receptor. (1997) (44)
Adenosine A(2A) receptors mediate coronary microvascular dilation to adenosine: role of nitric oxide and ATP-sensitive potassium channels. (1999) (44)
Does Adenosine Function as a Retaliatory Metabolite in the Heart (1992) (43)
Selective late sodium current blockade with GS-458967 markedly reduces ischemia-induced atrial and ventricular repolarization alternans and ECG heterogeneity. (2014) (43)
Antitorsadogenic Effects of (±)-N-(2,6-Dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (Ranolazine) in Anesthetized Rabbits (2008) (43)
Antiadrenergic action of adenosine on ventricular myocardium in embryonic chick hearts. (1982) (43)
Cellular basis for the negative dromotropic effect of adenosine on rabbit single atrioventricular nodal cells. (1996) (42)
Antiadrenergic and Hemodynamic Effects of Ranolazine in Conscious Dogs (2011) (42)
Effect of Ranolazine Monotherapy on Glycemic Control in Subjects With Type 2 Diabetes (2015) (41)
Endogenous adenosine is an antiarrhythmic agent. (1995) (41)
Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/− and human SCN5A-1795insD+/− iPSC-derived cardiomyocytes (2017) (41)
Adenosine-induced atrioventricular block: a rapid and reliable method to assess surgical and radiofrequency catheter ablation of accessory atrioventricular pathways. (1992) (41)
A slowly inactivating sodium current contributes to spontaneous diastolic depolarization of atrial myocytes. (2009) (41)
Effect of Adenosine on Atrioventricular Conduction. II: Modulation of Atrioventricular Node Transmission by Adenosine in Hypoxic Isolated Guinea Pig Hearts (1986) (41)
Effects of dipyridamole on coronary collateralization and myocardial perfusion in patients with ischaemic cardiomyopathy. (2001) (41)
Role of A2A‐adenosine receptor activation for ATP‐mediated coronary vasodilation in guinea‐pig isolated heart (2000) (41)
Ranolazine Effectively Suppresses Atrial Fibrillation in the Setting of Heart Failure (2014) (40)
Blockade of A2B adenosine receptor reduces left ventricular dysfunction and ventricular arrhythmias 1 week after myocardial infarction in the rat model. (2014) (39)
Sodium channel block by ranolazine in an experimental model of stretch-related atrial fibrillation: prolongation of interatrial conduction time and increase in post-repolarization refractoriness. (2013) (39)
Downregulation and desensitization of A1-adenosine receptors in embryonic chicken heart. (1989) (39)
A partial agonist of the A1-adenosine receptor selectively slows AV conduction in guinea pig hearts (2001) (39)
The Late Na+ Current (INa) Inhibitor Ranolazine Attenuates Effects of Palmitoyl-L-Carnitine to Increase Late INa and Cause Ventricular Diastolic Dysfunction (2009) (38)
Trial to Evaluate the Management of Paroxysmal Supraventricular Tachycardia During an Electrophysiology Study With Tecadenoson (2005) (38)
Effect of Ranolazine on Ventricular Vulnerability and Defibrillation Threshold in the Intact Porcine Heart (2008) (38)
Atrial-Selective Sodium Channel Block Strategy to Suppress Atrial Fibrillation: Ranolazine versus Propafenone (2012) (38)
Caffeine intake induces an alteration in human neutrophil A2A adenosine receptors (2005) (37)
Substituted 1,3-dipropylxanthines as irreversible antagonists of A1 adenosine receptors. (1994) (37)
Paroxysmal supraventricular tachycardia with Wenckebach block: evidence for reentry within the upper portion of the atrioventricular node. (1984) (37)
Cardiac glycoside stimulation of inward Ca++ current in vascular smooth muscle of canine coronary artery. (1979) (37)
Tonic activity of the rat adipocyte A1‐adenosine receptor (2002) (37)
Effect of ranolazine on ventricular repolarization in class III antiarrhythmic drug-treated rabbits. (2012) (36)
Selective A2-adenosine receptor agonists do not alter action potential duration, twitch shortening, or cAMP accumulation in guinea pig, rat, or rabbit isolated ventricular myocytes. (1993) (36)
Adenosine receptor antagonists and retinal neovascularization in vivo. (2001) (36)
New insights into the beneficial electrophysiologic profile of ranolazine in heart failure: prevention of ventricular fibrillation with increased postrepolarization refractoriness and without drug-induced proarrhythmia. (2012) (35)
Increased late sodium current in left atrial myocytes of rabbits with left ventricular hypertrophy: its role in the genesis of atrial arrhythmias. (2010) (35)
Myocardial infarction related atrial fibrillation: role of endogenous adenosine. (1997) (35)
Termination of paroxysmal supraventricular tachycardia by tecadenoson (CVT-510), a novel A1-adenosine receptor agonist. (2003) (35)
Ranolazine as a Cardioplegia Additive Improves Recovery of Diastolic Function in Isolated Rat Hearts (2009) (35)
Mechanisms of atrial-selective block of Na⁺ channels by ranolazine: II. Insights from a mathematical model. (2011) (35)
Adenosine: Cardiac Electrophysiology (1991) (35)
Sinus slowing and pacemaker shift caused by adenosine in rabbit SA node (2004) (34)
An apoptosis signal‐regulating kinase 1 inhibitor reduces cardiomyocyte apoptosis and infarct size in a rat ischemia‐reperfusion model (2012) (34)
Interstitial adenosine in guinea pig hearts: an index obtained by epicardial disks. (1990) (34)
Electrophysiological and functional effects of adenosine on ventricular myocytes of various mammalian species. (1996) (34)
Reduction in Preretinal Neovascularization by Ribozymes That Cleave the A2B Adenosine Receptor mRNA (2003) (34)
Reducing the Late Sodium Current Improves Cardiac Function during Sodium Pump Inhibition by Ouabain (2011) (34)
The novel CaMKII inhibitor GS-680 reduces diastolic SR Ca leak and prevents CaMKII-dependent pro-arrhythmic activity. (2018) (33)
The risk of sudden cardiac death in patients with non-ST elevation acute coronary syndrome and prolonged QTc interval: effect of ranolazine. (2013) (33)
Electrophysiological basis for the use of adenosine in the diagnosis and treatment of cardiac arrhythmias. (1990) (33)
Robust anti‐arrhythmic efficacy of verapamil and flunarizine against dofetilide‐induced TdP arrhythmias is based upon a shared and a different mode of action (2010) (33)
Validation of Furchgott's method to determine agonist‐dependent A1‐adenosine receptor reserve in guinea‐pig atrium (1998) (33)
Selective potentiation by an A1 adenosine receptor enhancer of the negative dromotropic action of adenosine in the guinea pig heart. (1993) (33)
Use of preclinical assays to predict risk of drug-induced torsades de pointes. (2005) (33)
Induction of atrioventricular node reentrant tachycardia with adenosine: differential effect of adenosine on fast and slow atrioventricular node pathways. (1997) (33)
Dromotropic effects of adenosine and adenosine antagonists in the treatment of cardiac arrhythmias involving the atrioventricular node. (1984) (33)
ATP promotes development of afterdepolarizations and triggered activity in cardiac myocytes. (1994) (32)
Ranolazine for rhythm control in atrial fibrillation: A systematic review and meta-analysis. (2017) (32)
Mechanism of the negative inotropic effect of adenosine in guinea pig atrial myocytes. (1994) (32)
Partial A(1) adenosine receptor agonists from a molecular perspective and their potential use as chronic ventricular rate control agents during atrial fibrillation (AF). (2004) (31)
Correlation of sinus slowing and hyperpolarization caused by adenosine in sinus node (2004) (31)
Role of endogenous adenosine in postdefibrillation bradyarrhythmia and hemodynamic depression. (1989) (31)
Selective attenuation by N-0861 (N6-endonorboran-2-yl-9-methyladenine) of cardiac A1 adenosine receptor-mediated effects in humans. (1996) (31)
A new method of sampling blood for measurement of plasma adenosine. (1990) (31)
Combined Actions of Ivabradine and Ranolazine Reduce Ventricular Rate During Atrial Fibrillation (2015) (31)
Expression and function of A2B adenosine receptors in the U87MG tumor cells (2003) (31)
Caffeine Attenuates the Duration of Coronary Vasodilation and Changes in Hemodynamics Induced by Regadenoson (CVT-3146), a Novel Adenosine A2A Receptor Agonist (2007) (30)
A Novel Partial Agonist of the A1 -Adenosine Receptor and Evidence of Receptor Homogeneity in Adipocytes (2006) (30)
LQTS mutation N1325S in cardiac sodium channel gene SCN5A causes cardiomyocyte apoptosis, cardiac fibrosis and contractile dysfunction in mice. (2011) (30)
Ambrisentan and Tadalafil Synergistically Relax Endothelin-Induced Contraction of Rat Pulmonary Arteries (2011) (30)
Intrapericardial Ranolazine Prolongs Atrial Refractory Period and Markedly Reduces Atrial Fibrillation Inducibility in the Intact Porcine Heart (2010) (29)
2-SUBSTITUTED PI SYSTEM DERIVATIVES OF ADENOSINE THAT ARE CORONARY VASODILATORS ACTING VIA THE A2A ADENOSINE RECEPTOR (2001) (29)
Ranolazine block of human Nav1.4 sodium channels and paramyotonia congenita mutants (2011) (29)
Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late INai) of the cardiac NaV 1.5 channel with improved efficacy and potency relative to ranolazine. (2016) (29)
Modulation of atrioventricular nodal function by metabolic and allosteric regulators of endogenous adenosine in guinea pig heart. (1996) (29)
Comparison of the antilipolytic effects of an A1 adenosine receptor partial agonist in normal and diabetic rats (2009) (28)
The novel late Na+ current inhibitor, GS‐6615 (eleclazine) and its anti‐arrhythmic effects in rabbit isolated heart preparations (2016) (28)
Reduction of Free Fatty Acids, Safety, and Pharmacokinetics of Oral GS‐9667, an A1 Adenosine Receptor Partial Agonist (2013) (28)
Differential A1‐adenosine receptor reserve for inhibition of cyclic AMP accumulation and G‐protein activation in DDT1 MF‐2 cells (2000) (28)
A novel irreversible antagonist of the A1-adenosine receptor. (1996) (27)
Acute dronedarone is inferior to amiodarone in terminating and preventing atrial fibrillation in canine atria. (2010) (27)
Selective late INa inhibition by GS-458967 exerts parallel suppression of catecholamine-induced hemodynamically significant ventricular tachycardia and T-wave alternans in an intact porcine model. (2015) (27)
Adenosine release during early and sustained exercise of canine skeletal muscle. (1980) (27)
A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current (2015) (26)
Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat. (2013) (26)
Overdrive suppression of automaticity in cultured chick myocardial cells. (1980) (26)
In silico assessment of drug safety in human heart applied to late sodium current blockers (2013) (26)
Unmasking atrial repolarization to assess alternans, spatiotemporal heterogeneity, and susceptibility to atrial fibrillation. (2016) (26)
Selective late sodium current inhibitor GS‐458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia (2018) (26)
Ranolazine Reduces Remodeling of the Right Ventricle and Provoked Arrhythmias in Rats with Pulmonary Hypertension (2015) (25)
Enhanced Depolarization Drive in Failing Rabbit Ventricular Myocytes: Calcium-Dependent and &bgr;-Adrenergic Effects on Late Sodium, L-Type Calcium, and Sodium-Calcium Exchange Currents (2019) (25)
Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late INai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties. (2016) (25)
Inhibition of the cardiac late sodium current with eleclazine protects against ischemia-induced vulnerability to atrial fibrillation and reduces atrial and ventricular repolarization abnormalities in the absence and presence of concurrent adrenergic stimulation. (2016) (24)
The Selective Cardiac Late Sodium Current Inhibitor GS‐458967 Suppresses Autonomically Triggered Atrial Fibrillation in an Intact Porcine Model (2015) (24)
1,3-Dipropyl-8-[2-(5,6-epoxy)norbornyl]xanthine, a potent, specific and selective A1 adenosine receptor antagonist in the guinea pig heart and brain and in DDT1MF-2 cells. (1995) (24)
Relation of T-wave alternans to mortality and nonsustained ventricular tachycardia in patients with non-ST-segment elevation acute coronary syndrome from the MERLIN-TIMI 36 trial of ranolazine versus placebo. (2014) (24)
Adenosine system in the heart (1993) (24)
Electrophysiological Characteristics of Canine Superior Vena Cava Sleeve Preparations: Effect of Ranolazine (2012) (24)
Eleclazine, a new selective cardiac late sodium current inhibitor, confers concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in an intact porcine model. (2016) (24)
Potent Antiarrhythmic Effects of Chronic Amiodarone in Canine Pulmonary Vein Sleeve Preparations (2009) (24)
Basis for the selective reduction of pulmonary vascular resistance in humans during infusion of adenosine. (1994) (23)
A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current (2016) (23)
A partial agonist of the A(1)-adenosine receptor selectively slows AV conduction in guinea pig hearts. (2001) (23)
Evidence of spare A1-adenosine receptors in guinea pig atrioventricular node. (1992) (23)
Ranolazine Reduces Neuronal Excitability by Interacting with Inactivated States of Brain Sodium Channels (2014) (22)
Novel approach for enhancing atrioventricular nodal conduction delay mediated by endogenous adenosine. (1994) (22)
Regulation of Atrioventricular Node Function by Adenosine (1987) (22)
Usefulness of adenosine in diagnosis of tachyarrhythmias. (1995) (22)
Role of adenosine as mediator of bradyarrhythmias during hypoxia in isolated guinea pig hearts. (1986) (22)
Evaluation of N-0861, (+-)-N6-endonorbornan-2-yl-9-methyladenine, as an A1 subtype-selective adenosine receptor antagonist in the guinea pig isolated heart. (1992) (21)
Partial A1 Adenosine Receptor Agonist Regulates Cardiac Substrate Utilization in Insulin-Resistant Rats in Vivo (2009) (21)
Role of adenosine on ventricular overdrive suppression in isolated guinea pig hearts and Purkinje fibers. (1985) (21)
Selective Attenuation of Isoproterenol-Stimulated Arrhythmic Activity by a Partial Agonist of Adenosine A1 Receptor (2002) (21)
Eleclazine, an inhibitor of the cardiac late sodium current, is superior to flecainide in suppressing catecholamine-induced ventricular tachycardia and T-wave alternans in an intact porcine model. (2017) (21)
An unusual receptor mediates adenosine-induced SA nodal bradycardia in dogs. (1989) (21)
Ranolazine terminates atrial flutter and fibrillation in a canine model. (2014) (20)
Effects of Ranolazine in Patients With Chronic Angina in Patients With and Without Percutaneous Coronary Intervention for Acute Coronary Syndrome: Observations From the MERLIN‐TIMI 36 Trial (2015) (20)
Homologous desensitization of the A1-adenosine receptor system in the guinea pig atrioventricular node. (1995) (20)
The Beneficial Effects of Ranolazine on Cardiac Function After Myocardial Infarction Are Greater in Diabetic Than in Nondiabetic Rats (2014) (20)
The Negative Chronotropic Effect of Adenosine in Sinus Node Cells (1987) (20)
Blockade of Ca2+ dependent rat atrial slow action potentials by adenosine and lanthanum (1979) (20)
Block of Na+ currents and suppression of action potentials in embryonic rat dorsal root ganglion neurons by ranolazine (2012) (20)
Persistent activation by and receptor reserve for an irreversible A1-adenosine receptor agonist in DDT1 MF-2 cells and in guinea pig heart. (1997) (19)
Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with improved efficacy and potency relative to ranolazine. (2016) (19)
Contribution of the late sodium current to intracellular sodium and calcium overload in rabbit ventricular myocytes treated by anemone toxin. (2016) (19)
Effect of ranolazine on left ventricular dyssynchrony in patients with coronary artery disease. (2012) (19)
Restoration of slow responses in hypoxic heart muscle by alkaline pH. (1979) (19)
Potentiating Effect of Acetylcholine on Stimulation by Isoproterenol of L‐Type Ca2+ Current and Arrhythmogenic Triggered Activity in Guinea Pig Ventricular Myocytes (1998) (19)
Sinus node dysfunction in ATX-II-induced in-vitro murine model of long QT3 syndrome and rescue effect of ranolazine. (2008) (19)
The cardiac effects of a novel A1-adenosine receptor agonist in guinea pig isolated heart. (1994) (19)
Basal late sodium current is a significant contributor to the duration of action potential of guinea pig ventricular myocytes (2017) (18)
Effect of theophylline on the warm-up phenomenon. (1999) (18)
Inhibition of late sodium current attenuates ionic arrhythmia mechanism in ventricular myocytes expressing LaminA-N195K mutation. (2016) (17)
Effectiveness of ranolazine in patients with type 2 diabetes mellitus and chronic stable angina according to baseline hemoglobin A1c. (2013) (17)
Dose and Time Effects of Caffeine Intake on Human Platelet Adenosine A 2 A Receptors Functional and Biochemical Aspects (2000) (17)
The effect of ranolazine on the vasodilator-induced myocardial perfusion abnormality (2011) (17)
Inhibition of I(f) in the atrioventricular node as a mechanism for dronedarone's reduction in ventricular rate during atrial fibrillation. (2013) (17)
Selective attenuation by adenosine of arrhythmogenic action of isoproterenol on ventricular myocytes. (2001) (17)
Synergy between A 2 B Adenosine Receptors and Hypoxia in Activating Human Lung Fibroblasts (2004) (16)
The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology. (2016) (16)
Nav 1 . 5-dependent persistent Na influx activates CaMKII in rat ventricular myocytes and N 1325 S mice (2011) (16)
Atria are More Sensitive Than Ventricles to GS-458967-Induced Inhibition of Late Sodium Current (2015) (16)
N-[3-(R)-Tetrahydrofuranyl]-6-aminopurine Riboside, an A1 Adenosine Receptor Agonist, Antagonizes Catecholamine-Induced Lipolysis without Cardiovascular Effects in Awake Rats (2003) (16)
Effects of adenosine and a selective A2A adenosine receptor agonist on hemodynamic and thallium-201 and technetium-99m-sestaMIBI biodistribution and kinetics. (2009) (16)
A common co-morbidity modulates disease expression and treatment efficacy in inherited cardiac sodium channelopathy (2018) (16)
A temporal window of vulnerability for development of atrial fibrillation with advancing heart failure (2014) (15)
Effects of hypoxia and ischaemia on coronary vascular resistance, A-V node conduction and S-A node excitation. (2009) (15)
1068-128 Ranolazine inhibits late sodium current in isolated left ventricular myocytes of dogs with heart failure (2004) (15)
A mechanistic approach to assess the proarrhythmic risk of QT-prolonging drugs in preclinical pharmacologic studies. (2004) (15)
Atrial Fibrillation Initiated by Early Afterdepolarization-Mediated Triggered Activity during Acute Oxidative Stress: Efficacy of Late Sodium Current Blockade (2018) (15)
Protein kinase C and Ca2+–calmodulin‐dependent protein kinase II mediate the enlarged reverse INCX induced by ouabain‐increased late sodium current in rabbit ventricular myocytes (2015) (15)
Ranolazine Injection Into Coronary or Femoral Arteries Exerts Marked, Transient Regional Vasodilation Without Systemic Hypotension in an Intact Porcine Model (2011) (15)
Pro-arrhythmic effects of low plasma [K+] in human ventricle: An illustrated review. (2017) (15)
Eleclazine exhibits enhanced selectivity for long QT syndrome type 3-associated late Na+ current. (2017) (14)
CrossTalk proposal: The late sodium current is an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction) (2014) (14)
Enhanced late sodium current underlies pro-arrhythmic intracellular sodium and calcium dysregulation in murine sodium channelopathy. (2018) (14)
Dronedarone's Inhibition of If Current Is the Primary Mechanism Responsible for Its Bradycardic Effect (2013) (14)
Age-Dependent Atrial Remodeling Induced by Recombinant Human Interleukin-11: Implications for Atrial Flutter/Fibrillation (2002) (14)
Response to letter regarding article, "Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy". (2013) (13)
Cardiovascular effects of a non-xanthine-selective antagonist of the A1 adenosine receptor in the anaesthetised pig: pharmacological and therapeutic implications. (1994) (13)
Selective Inhibition of the Late Sodium Current has No Adverse Effect on Electrophysiological or Contractile Function of the Normal Heart (2014) (13)
RANOLAZINE FOR THE TREATMENT OF DIASTOLIC HEART FAILURE IN PATIENTS WITH PRESERVED EJECTION FRACTION: RESULTS FROM THE RALI-DHF STUDY (2012) (12)
Differential antagonism of cardiac actions of adenosine by theophylline. (1996) (12)
Inhibitions of late INa and CaMKII act synergistically to prevent ATX-II-induced atrial fibrillation in isolated rat right atria. (2016) (12)
Modulation of late sodium current by Ca2+–calmodulin‐dependent protein kinase II, protein kinase C and Ca2+ during hypoxia in rabbit ventricular myocytes (2017) (12)
Effect of ranolazine on glycaemic control in patients with type 2 diabetes treated with either glimepiride or metformin (2016) (12)
Regadenoson, a Novel Pharmacologic Stress Agent for Use in Myocardial Perfusion Imaging, Does Not Have a Direct Effect on the QT Interval in Conscious Dogs (2008) (12)
Inhibition of IKr potentiates development of atrial-selective INa block leading to effective suppression of atrial fibrillation. (2015) (12)
Accelerated conversion of atrial fibrillation to normal sinus rhythm by pulmonary delivery of flecainide acetate in a porcine model. (2018) (12)
Ranolazine Attenuates Hypoxia- and Hydrogen Peroxide-induced Increases in Sodium Channel Late Openings in Ventricular Myocytes (2014) (12)
Absence of adenosine-induced chest pain after total cardiac afferent denervation. (1993) (11)
Hyperkalemia enhances the effect of adenosine on IK,ADO in rabbit isolated AV nodal myocytes and on AV nodal conduction in guinea pig isolated heart. (1999) (11)
Effects of adenosine on ventricular tachycardia. (1987) (11)
Balance Between Rapid Delayed Rectifier K+ Current and Late Na+ Current on Ventricular Repolarization (2020) (11)
Differential effects of adenosine on antegrade and retrograde fast pathway conduction in atrioventricular nodal reentry. (1997) (10)
Effects of Extracellular Adenosine and Atp on Cardiomyocytes (1998) (10)
Mechanisms of atrial-selective block of sodium channel by ranolazine 2 I . Experimental analysis of the use-dependent block 3 4 (2011) (10)
Restoration of inward slow current in hypoxic heart muscle by alkaline pH (1978) (10)
Adenosine A 2 A Receptors Mediate Coronary Microvascular Dilation to Adenosine : Role of Nitric Oxide and ATP-Sensitive Potassium Channels 1 (1999) (10)
Nonspecific inhibition of adenosine-activated K+ current by glibenclamide in guinea pig atrial myocytes. (1996) (10)
Potentiation of the negative dromotropic effect of adenosine by rapid heart rates: possible ionic mechanism (2002) (10)
Contribution of IK,ADO to the negative dromotropic effect of adenosine (2002) (10)
Ranolazine as an Adjunct to Cardioplegia: A Potential New Therapeutic Application (2009) (10)
Adenosine blockade as primary therapy for ischemia-induced accelerated idioventricular rhythm: rationale and potential clinical application. (1994) (10)
Myocardial Adenosine Receptors (1995) (10)
Adenosine A₁ receptors do not play a major role in the regulation of lipogenic gene expression in hepatocytes. (2012) (9)
Does Recombinant Human Interleukin-11 Exert Direct Electrophysiologic Effects on Single Human Atrial Myocytes? (2002) (9)
Pulmonary Delivery of Antiarrhythmic Drugs for Rapid Conversion of New-Onset Atrial Fibrillation (2020) (9)
Overexpression of SCN5A in mouse heart mimics human syndrome of enhanced atrioventricular nodal conduction. (2015) (9)
Renal effects of BG9719, a specific A1 adenosine receptor antagonist, in congestive heart failure (1998) (9)
A Novel Partial Fatty Acid Oxidation Inhibitor Decreases Myocardial Oxygen Consumption and Improves Cardiac Efficiency in Demand-induced Ischemic Heart (2008) (9)
The mechanism research of hypoxia-induced increased late sodium current resulting in intracellular Ca2+ overload in ventricular myocytes (2017) (8)
Late INa Blocker GS967 Supresses Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long QT Type 2 (2020) (8)
Negative chronotropic effect of CVT‐510 in anesthetized and awake rats (2001) (8)
Comparative Pharmacokinetic and Electrocardiographic Effects of Intratracheal and Intravenous Administration of Flecainide in Anesthetized Pigs (2018) (8)
Optimizing flecainide plasma concentration profile for atrial fibrillation conversion while minimizing adverse ventricular effects by rapid, low-dose intratracheal or intravenous administration. (2019) (8)
Carbon monoxide effects on human ventricle action potential assessed by mathematical simulations (2013) (8)
Abnormal left ventricular relaxation in patients with long QT syndrome. (2009) (8)
Mechanisms by Which Ranolazine Terminates Paroxysmal but Not Persistent Atrial Fibrillation. (2019) (7)
Adenosine A 2 A Receptors Mediate Coronary Microvascular Dilation to Adenosine : Role of Nitric Oxide and ATPSensitive ATPSensitive ATPSensitive Potassium Channels 1 (1999) (7)
Selective inhibition of physiological late Na+ current stabilizes ventricular repolarization. (2018) (7)
Abstract 13798: Effect of Ranolazine on Atrial Fibrillation Among Patients with Non-ST Elevation Acute Coronary Syndromes (NSTEACS) - Observations from the MERLIN-TIMI 36 Trial (2011) (7)
Pulmonary delivery of flecainide causes a rate‐dependent predominant effect on atrial compared with ventricular depolarization duration revealed by intracardiac recordings in an intact porcine model (2018) (7)
induced arrhythmogenic activity and contractile dysfunction (2006) (7)
Modulation of atrioventricular transmission by adenosine. (1987) (6)
Glucose-Lowering Medications and Angina Burden in Patients with Stable Coronary Disease: results from the Type 2 Diabetes Evaluation of Ranolazine in Subjects With Chronic Stable Angina (TERISA) Trial. (2015) (5)
CVT-4325 Inhibits Myocardial Fatty Acid Uptake and Improves Left Ventricular Systolic Function without Increasing Myocardial Oxygen Consumption in Dogs with Chronic Heart Failure (2007) (5)
Cardiac electrophysiological actions of adenosine (1998) (5)
Mechanism of the Preferential Block of the Atrial Sodium Current by Ranolazine (2009) (5)
Rationale for the Use of Adenosine in the Diagnosis and Treatment of Cardiac Arrhythmias (1990) (5)
The first second-generation adenosine drug enters the US market (2008) (5)
Multimodal mechanisms and enhanced efficiency of atrial fibrillation cardioversion by pulmonary delivery of a novel flecainide formulation (2019) (5)
Ranolazine, a Novel Anti‐Anginal Agent, Does Not Alter Isosorbide Dinitrate‐ or Sildenafil‐Induced Changes in Blood Pressure in Conscious Dogs (2006) (5)
Increase in late sodium current and cellular uncoupling exacerbates transmural dispersion of repolarization in heart failure (2012) (4)
Pro-Fibrotic Role of the A2B Adenosine Receptor in Human Cardiac Fibroblasts (2011) (4)
Inhibition of late Na+ current, a novel target to improve diastolic function and electrical abnormalities in Dahl salt-sensitive rats. (2016) (4)
Flecainide-Induced QRS Complex Widening Correlates with Negative Inotropy. (2021) (4)
Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a1798insD/+ mice (2020) (4)
Conditional-dependent effects of CVT-4325, a novel fatty acid oxidation inhibitor, on palmitate utilization (2003) (4)
Late Sodium Current Is an Intrinsic Regulator of Cardiac Repolarization—A Quantitative Assessment (2012) (4)
Poster session 2 (2004) (4)
Selective action of metoprolol to attenuate regadenoson-induced tachycardia in conscious dogs (2012) (4)
Abstract 16790: Anti-Arrhythmic Properties of a Novel Cardiac Late Na+ Current Inhibitor, GS-6615, in a Mouse Model of Long QT Type 3 (2014) (3)
Pulmonary Delivery of Metoprolol Reduces Ventricular Rate during Atrial Fibrillation and Accelerates Conversion to Sinus Rhythm. (2019) (3)
Effects of intracoronary dipyridamole infusion on regional myocardial blood flow and intrinsic thallium-201 washout in dogs with a critical coronary stenosis. (1992) (3)
Abstract 19745: Brugada, Long QT and Cardiac Conduction Disease Overlap Syndrome Associated with the SCN5A-E1784K Mutation: Clinical Phenotype, Genetic Background and Potential Therapy (2012) (3)
Adenosine and Atp-Regulated Ion Currents in Cardiomyocytes (1995) (3)
The A 2 A Adenosine Receptor Mediates Coronary Vasodilation 1 (1998) (3)
Simulation study of the electrophysiological mechanisms for heart failure phenotype (2011) (3)
Effect of autonomic influences to induce triggered activity in muscular sleeves extending into the coronary sinus of the canine heart and its suppression by ranolazine (2018) (3)
Abstract 15308: Reduction of LV Diastolic Wall Tension by Ranolazine Led to Improved Diastolic Coronary Blood Flow During Demand-Induced Acute Myocardial Ischemia in Anesthetized Canine (2013) (3)
Selective Inhibition of Late Na+ Current Reduces Arrhythmic Activity in Spontaneously Hypertensive Rat Myocytes (2014) (3)
Modulation of Cardiomyocyte Membrane Currents by A 1 Adenosine Receptors (1995) (3)
[345] PRO-FIBROTIC ROLES OF THE A2B ADENOSINE RECEPTOR IN HUMAN PRIMARY HEPATIC STELLATE CELLS (2007) (3)
Enhanced basal late sodium current appears to underlie the age-related prolongation of action potential duration in guinea pig ventricular myocytes. (2018) (2)
Abstract 16247: Oxidative Stress Initiates Atrial Fibrillation in Fibrotic Hearts by Early Afterdepolarization-Mediated Triggered Activity. The Key Role of Late INa (2014) (2)
SELECTIVE BLOCKADE OF A2B ADENOSINE RECEPTOR REDUCES CARDIAC REMODELING FOLLOWING ACUTE MYOCARDIAL INFARCTION IN THE MOUSE (2012) (2)
EXPRESSION OF LYSYL OXIDASE-LIKE 2 (LOXL2) CORRELATES WITH LEFT ATRIAL SIZE AND FIBROTIC GENE EXPRESSION IN HUMAN ATRIAL FIBRILLATION (2014) (2)
The electrophysiological effects of ranolazine in a goat model of lone atrial fibrillation. (2020) (2)
1170-142 Differential vasodilatory effects of CVT-3146, an A2Aadenosine receptor agonist in various vascular beds in anesthetized dogs (2004) (2)
Method for treating atrial fibrillation (2010) (2)
Failure of adenosine to terminate focal atrial tachycardia (1993) (2)
OUABAIN INCREASES LATE SODIUM CURRENT BY A CA2+/CALMODULIN KINASE-MEDIATED MECHANISM (2010) (2)
ASK1 promotes maladaptive remodeling in a rodent model of pulmonary hypertension (2014) (2)
Response of Large and Small Coronary Arteries to Adenosine, Nitroglycerin, Cardiac Glycosides, and Calcium Antagonists (1980) (2)
An example of the clinical selectivity of regadenoson for the A2a adenosine receptor. (2009) (2)
Abstract 11990: Ranolazine Reduces Monocrotaline-induced Pulmonary Hypertension when Administered Following Disease Induction (2012) (2)
The Selective Late Sodium Current Inhibitor Eleclazine, Unlike Amiodarone, Does Not Alter Defibrillation Threshold or Dominant Frequency of Ventricular Fibrillation (2017) (2)
Beneficial Effects Of Ranolazine In A Model Of Pulmonary Hypertension And Right-Sided Heart Failure (2011) (2)
Poster Session 2 (2009) (2)
Contribution of Local Anesthetic Binding Site Residues F1760 and Y1767 to Block of the Cardiac Na+ Channel, hNaV1.5, by Ranolazine (2012) (2)
Anti-Torsadogenic Effects of Ranolazine in Anesthetized Rabbits (2008) (2)
T-WAVE ALTERNANS (TWA) IS ASSOCIATED WITH CARDIOVASCULAR MORTALITY AND NSVT IN THE MERLIN-TIMI 36 TRIAL OF RANOLAZINE VERSUS PLACEBO IN PATIENTS WITH NON-ST SEGMENT elevation ACUTE CORONARY SYNDROME (2013) (2)
Open-Label, Multicenter Study of Flecainide Acetate Oral Inhalation Solution for Acute Conversion of Recent-Onset, Symptomatic Atrial Fibrillation to Sinus Rhythm (2022) (2)
39.21: Heart Rate Response to Adenosine and Regadenoson in Patients with Diabetes: Evidence for Sympathetic Denervation (2007) (2)
Theophylline and Atrioventricular Block (1996) (1)
Effects of CVT-3146, a novel coronary vasodilator under development for use in myocardial imaging, on A2A-adenosine receptors of human platelets and neutrophils (2005) (1)
RESEARCH PAPER Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different (2010) (1)
Mechanisms of flecainide induced negative inotropy: An in silico study. (2021) (1)
Ranolazine Causes Atrial-Selective Electrophysiological Effects and Suppresses the Induction of Atrial Fibrillation in a Canine Model of Heart Failure (2012) (1)
Cardiac Electrophysiological Effects of Adenosine (1988) (1)
conduction. Mechanism and physiological implications Species-dependent effects of adenosine on heart rate and atrioventricular nodal (2011) (1)
P791A common co-morbidity modulates disease expression and treatment efficacy in inherited cardiac sodium channelopathy (2018) (1)
Ranolazine inhibits hypoxia‐stimulated late sodium current (2008) (1)
Abstract 13310: Selective Inhibition of the Late Sodium Current to Prevent Ventricular Fibrillation (2013) (1)
TCT-719 Effects of ranolazine in patients with acute coronary syndrome and stable angina according to whether they undergo percutaneous coronary intervention: Observations from the MERLIN-TIMI 36 Trial (2012) (1)
Electrophysiologic Disorders Termination of Paroxysmal Supraventricular Tachycardia by Tecadenoson ( CVT-510 ) , a Novel A 1-Adenosine Receptor Agonist (2016) (1)
Reply: In regard to the TERISA trial. (2014) (1)
P6-9: Ranolazine suppresses atrial fibrillation by exerting a marked use-dependent block of sodium channel current in canine atrium but not ventricle (2006) (1)
Effects of verapamil and diltiazem on the ventricular rate during simulated atrial flutter in isolated guinea pig hearts. (1996) (1)
A population pharmacokinetic/pharmacodynamic analysis of regadenoson, an A2A adenosine receptor agonist, in healthy subjects (2005) (1)
Abstract 15739: Effects of Ranolazine on Long QT3 Syndrome are Mutation Dependent (2011) (1)
Pathological Roles of the Cardiac Sodium Channel Late Current (Late INa) (2013) (1)
Comparison of vasodilation by CVT-3146, a novel A2Areceptor agonist, and adenosine in different vascular beds in awake dogs (2003) (1)
Correlation of (-)N6-phenylisopropyladenosine blood levels with cardiac responses in the anesthetized guinea pig. (1993) (1)
Abstract 2667: Effects of Ranolazine in a Goat Model of Lone Atrial Fibrillation (2009) (1)
Intracellular Na+ Overload of Cardiomyocytes Causes ROS Induced CaMKII Activation, Leading to RYR Dysfunction and Diastolic Ca2+ Mishandling (2013) (1)
Effect of chronic caffeine intake on A2A adenosine receptors in human neutrophils. (2005) (1)
Inhibition of late Na current by ranolazine reduces torsades de pointes arrhythmias in the dog with chronic atrioventricular block (2008) (1)
Mechanism of tachycardia during myocardial perfusion imaging with adenosine (2004) (1)
Na+ channel regulation, structure, trafficking and sequestration (2015) (1)
Myocardial perfusion imaging with a novel selective A2a adenosine receptor agonist (CVT-3146): Important differences in radiotracer behavior (2003) (1)
805-1 Theophylline Reverses Myocardial Infarction-Related Brady and Tachy Arrhythmias: Role of Adenosine (1995) (1)
Effects Of Endothelin Receptor Antagonists And Tadalafil On Plasma Volume Expansion In Normal Salt Fed Dahl S Rats (2012) (1)
P3810Hysteresis between pharmacokinetics and changes in QRS complex duration following flecainide administered via oral inhalation or IV infusion (2018) (1)
Antiadrenergic effect of adenosine on ventricular slow action potentials in embryonic chick hearts (1981) (1)
Compositions and methods of treatment of pulmonary hypertension (2011) (1)
The Role of Cellular Sodium and Calcium Loading in Cardiac Energetics and Arrhythmogenesis: Contribution of the Late Sodium Current (2008) (1)
A population pharmacokinetic/pharmacodynamic analysis of regadenoson, an A2A adenosine receptor agonist, suggests unit-based dosing in humans (2005) (1)
P119Changes of the late sodium current and the inward rectifier potassium current can contribute to generation of arrhythmias in heart failure (2014) (0)
ARRHYVTILM Adenosine : electrophysiologic effects and therapeutic use for terminating paroxysmal supraventricular tachycardia (2005) (0)
Abstract 14657: Comparison of the Seattle Angina Questionnaire With Daily Angina Diary Entry (2013) (0)
Coronary microcirculatory vasoconstriction induced by low‐flow ischemia in mouse hearts is reversed by an A2A adenosine receptor agonist (2007) (0)
Ambrisentan and tadalafil synergistically attenuate chronic hypoxia-induced PAH in rats (2013) (0)
treatment of guinea pigs with theophylline. Enhanced sensitivity of heart cells to adenosine and up-regulation of receptor number after (2013) (0)
The slow activating, delayed rectifier K+ current is a major component of repolarization reserve (2005) (0)
Effects of adenosine on the SA and AV nodes in different species. (1990) (0)
Diabetic Than in Nondiabetic Rats The Beneficial Effects of Ranolazine on Cardiac Function After Myocardial Infarction Are Greater in (2014) (0)
THE LATE SODIUM CURRENT INHIBITOR ELECLAZINE SUPPRESSES ATRIAL PREMATURE BEATS AND ATRIAL FIBRILLATION IN AN INTACT PORCINE MODEL (2016) (0)
IMPACT OF TYPE OF STRESS ON REDUCTION IN PERFUSION DEFECT SIZE BY RANOLAZINE IN PATIENTS WITH CORONARY ARTERY DISEASE (2010) (0)
Use-Dependent Block of Nav1.4 Human Paramyotonia Congenita Mutation By Ranolazine (2010) (0)
ISCHEMIC CHALLENGE BY “STEAL” OF MYOCARDIAL BLOOD FLOW INDUCED BY ADENOSINE AND ADENOSINE-A1 BLOCKER IN A PIG MODEL (1992) (0)
Role of endogenous adenosine on S-A and A-V nodes activity in different species (1990) (0)
Ranolazine Improves Diastolic Dysfunction through Modulation of the Late Sodium Current (2009) (0)
Role of Increased Ca2+/Calmodulin-Dependent Protein Kinase II and Late Na+ Current in the Diastolic Dysfunction and Electrical Instability of Human Hypertrophic Cardiomyopathy (2011) (0)
Enhancement of Slow Inactivation of Voltage-Gated Na+ Channels by Ranolazine (2011) (0)
Additional evidence for adenosine mediation of A-V conduction disturbances in canine myocardium (1981) (0)
vascular development in neonatal rats with hyperoxic lung injury Ambrisentan reduces pulmonary arterial hypertension but does not stimulate alveolar and (2015) (0)
adenosine receptor by adenine nucleotides. Electrophysiological and receptor binding studies to assess activation of the cardiac (2013) (0)
contribution of Ca and K currents Adenosine-induced changes in atrial action potential: (2012) (0)
Abstract 15303: GS-458967, a Selective Late Sodium Current Inhibitor, Prohibits Torsades de Pointes Arrhythmias in the Chronic Atrioventricular Block Dog Model (2014) (0)
PULMONARY DELIVERY OF THE CLASS IC ANTIARRHYTHMIC AGENT FLECAINIDE EXERTS A PREDOMINANT EFFECT ON ATRIAL COMPARED TO VENTRICULAR DEPOLARIZATION DURATION REVEALED BY INTRACARDIAC RECORDINGS (2018) (0)
Abstract 17574: Effects of Ranolazine on Disease-Specific Health Status and Quality of Life Among Patients With Diabetes and Stable Angina: Results From the TERISA Randomized Trial (2013) (0)
Block of Na+ Currents and Suppression of Action Potentials in Cultured Hippocampal Neurons by Gs-458967 (2014) (0)
mutation N 1325 S in cardiac sodium channel gene SCN 5 A causes cardiomyocyte apoptosis , cardiac fi brosis and contractile dysfunction in mice (2009) (0)
New agonists and antagonists of A1 adenosine receptor. (1996) (0)
Atrial selectivity of ranolazine 1 1 2 3 SUPPLEMENTAL MATERIAL 4 5 6 Mechanisms of atrial-selective block of sodium channel by ranolazine 7 I . Experimental analysis of the use-dependent block 8 9 (2011) (0)
ADENOSINE REDUCES HALOTHANE MAC IN DOGS (1989) (0)
ELECTROPHYSIOLOCiIC Adenosine-Induced Atrioventricuiar Block: A Rapid and Reliable Method to Assess Surgical and Radiofrequency Catheter Ablation of Accessory Atrioventricular Pathways (2016) (0)
Abstract 2697: Role of Physiological Late Sodium Current in the Reverse-use Dependency of Potassium Current Inhibitors (2009) (0)
723-2 Selective Antagonism of Adenosine A1Receptor Mediated Effects in Humans with N-0861, (N6-Endonorboran-2-yl-9-Methyladenine) (1995) (0)
Beta-Adrenergic Response in Human HCM Myocardium: Effects of Ranolazine (2014) (0)
Heterocyclic derivatives substituted 5-thio, in position n-6 adenosine agonists or partial a1 receptors. (2000) (0)
Increased Nav 1.5 channel late current underlies prolongation of action potential duration of ventricular myocytes from aged guinea pigs (2013) (0)
SELECTIVE LATE INA INHIBITION BY GS967 EXERTS POTENT SUPPRESSION OF CATECHOLAMINE-INDUCED VENTRICULAR TACHYCARDIA (2015) (0)
Determinants of Abnormal Excitation-Contraction Coupling in Cardiomyocytes from Patients with Hypertrophic Cardiomyopathy (2013) (0)
The adenosine A2B receptor antagonist GS-6201 reduces small artery muscularization and plasma endothelin-1 in a short term cigarette smoke exposure model (2012) (0)
The Expression And Function Of Adenosine Receptor Subtypes In Primary Human Pulmonary Arterial Smooth Muscle Cells And Endothelial Cells - Potential Role Of A2B Adenosine Receptor In Pulmonary Hypertension (2011) (0)
PII‐57 (2006) (0)
Chronotropic and dromotropic effects of adenosine: physiological consequences (1990) (0)
Advances in Clinical Trials Novel Approach Targeting the Complex Pathophysiology of Hypertrophic Cardiomyopathy Designing the Late Sodium Current Inhibition With Eleclazine on Exercise Capacity in Subjects With Symptomatic Hypertrophic Cardiomyopathy Trial (2016) (0)
Elevated levels of adenosine in the lungs lead to chronic lung injury and pulmonary hypertension (2011) (0)
Flecainide, but not Ranolazine, Causes Use‐ and State‐dependent Slowing of Ventricular Conduction in Female Rabbit Hearts (2008) (0)
Abstract 2865: Ventricular Rate Control using the Adenosine Receptor Agonist CVT510 in the Goat Model of Atrial Fibrillation: Efficacy During Exercise and Synergistic Effects with Metoprolol (2007) (0)
Effects of a new selective A2a adenosine receptor agonist on Thallium-201 and Tcm99-MIBI biodistribution and clearance: Implications for optimizing vasodilator stress perfusion imaging (2003) (0)
A simulation tool to assess the pro-arrhythmic potential of ion channel blockers (2012) (0)
Ranolazine and Dofetilide Effectively Suppress Acute Atrial Fibrillation in Isolated Sheep Hearts (2013) (0)
Abstract 188: Comparison of Physician- and Patient-Assessed Impressions of Treatment Efficacy: Insights from the TERISA Clinical Trial (2014) (0)
Proteomic Profiling of Bronchioalveolar Lavage from Mice Exhibiting Adenosine-Dependent Lung Disease. (2009) (0)
Increased CAMKII Activity Impairs Contractile Function in Human HCM Myocardium (2014) (0)
Alleviation of AF related symptoms following acute conversion of recent-onset, symptomatic atrial fibrillation to sinus rhythm with flecainide acetate oral inhalation solution (2022) (0)
The Adenosine A2B Receptor Modulates Pulmonary Hypertension Associated With Chronic Lung Disease (2011) (0)
Cellular Reactive Oxygen Species–Activated Ca/Calmodulin Kinase II (cid:1) Is Required for Late I Na Augmentation Leading to Cellular Na and Ca Overload (2011) (0)
Mechanical Effects of Late Na-Current Blockers in Human Hypertrophic Cardiomyopathy Myocardium (2015) (0)
Regulation of endogenous norepinephrine release from the guinea pig heart (1988) (0)
EFFECT OF RANOLAZINE ON LEFT VENTRICULAR DYSSYNCHRONY (2011) (0)
1110-213 Ranolazine attenuates increased variability of action potential duration and after depolarizations caused by augmentation of late sodium current (2004) (0)
A catheter‐syringe sampling system for measurement of adenosine in coronary sinus blood in humans (1992) (0)
Method for the treatment of cardiac arrhythmia with a a1 adenosine agonist with a beta blocker (2003) (0)
Platelet Release andThromboxane Synthesis inSymptomatic Coronary ArteryDisease (1982) (0)
Agonists and antagonists of adenosine receptors a1. (1994) (0)
Fast delivery of flecainide via the pulmonary (bolus) or intravenous (rapid infusion) routes reduces atrial fibrillation conversion dose and minimizes negative inotropic burden (2020) (0)
Abstract 15502: Role of Enhanced Late Na+ Current in the Generation of Ventricular Arrhythmias in Dahl Salt-Sensitive Rats (2013) (0)
Dynamic Late Na Current During Cardiac Action Potential Revealed by a Specific and Potent Inhibitor Gs967 (2014) (0)
Method of treating arrhythmias comprising administering Quie an adenosine A1 agonist with a beta blocker. (2003) (0)
Abstract 9963: The A2B Adenosine Receptor Antagonist (GS-6201) Improves Cardiac Remodeling and Dysfunction after Myocardial Infarction (MI) in Rat (2012) (0)
Ultra-rapid kinetic interactions of ranolazine with Herg K+ current (2007) (0)
A2B adenosine receptors mediate human lung fibroblast differentiation via releasing IL-6 (2004) (0)
Sourck of adenosine during sympathetic nervs stimulation in guinea pig heart (1988) (0)
Abstract 16820: CaMKIIδc Transgenic Mice Develop Spontaneous Ventricular Arrhythmias Which Can Be Suppressed by Inhibition of Late Na+ Current (2014) (0)
Ventral Neurons of the Neonatal Rat Currents by Activation of Protein Kinase C in Spinal Modulation of Transient and Persistent Inward (2015) (0)
Abstract 2316: Ranolazine, a Late Sodium Current Inhibitor, as an Adjunct to Cardioplegia Further Reduces Contracture during Ischemia and Reperfusion (2008) (0)
Abstract 11926: Pharmacological Targeting of Late Na+ Current Reduces Cardiac Ventricular Action Potential Sensitivity to Small Electrical Perturbations (2013) (0)
Abstract 2755: Ranolazine is a Potent Antiarrhythmic Agent That Reduces Ventricular Arrhythmias by Inhibition of the Late Sodium Channel (2009) (0)
Regional differences in transmembrane action potential (AP) in guinea pig heart during global ischemia (1980) (0)
Simulated Block of Brain Na+ Channels by Ranolazine Predicts Selective Binding to Inactivated Conformations (2012) (0)
EVALUATION OF A NEW ADENOSINE A1 BLOCKER AND ITS EFFECTIVENESS IN TREATING ATRIOVENTRICULAR CONDUCTION DELAY IN PIGS (1992) (0)
Use of ranolazine for the manufacture of a medicament for treating arrhythmias (2003) (0)
Blocking the Late Sodium Current Reduces Intracellular Sodium Accumulation During Sodium Pump Inhibition (2009) (0)
THE ANTI-ISCHEMIC EFFECT OF RANOLAZINE CLOSELY PARALLELS ITS QTC-SHORTENING EFFECT IN PATIENTS WITH LONG-QT SYNDROME 3 (2013) (0)
Ranolazine attenuates hydrogen peroxide‐induced increases in late sodium‐channel open probability and open time (2008) (0)
Effects of Ranolazine on Paroxysmal and Persistent Atrial Fibrillation in Isolated Sheep Hearts (2012) (0)
Abstract 14019: Electrophysiological Effects of the Late Sodium Current Inhibitor GS967 in Scn5a-1798insD Mouse and Human SCN5A-1795insD iPSC-derived Cardiomyocytes (2014) (0)
Abstract 2691: Persistent Atrial Fibrillation Causes Remodelling of Na Currents: Impact of INa Inhibition by Ranolazine on Arrhythmias and Contractility (2009) (0)
Ranolazine normalizes action potential repolarization of hypertrophied ventricular cardiomyocytes (2007) (0)
Predictors of successful cardioversion of recent-onset atrial fibrillation to sinus rhythm with orally inhaled flecainide (2022) (0)
Abstract 9171: An Increase in Late Sodium Current Causes Junctional Tachycardia in Mice Expressing an LQT3 SCN5A Mutant Na+ Channel (2011) (0)
Pharmacologic evidence of spare a 1 adenosine receptors in the guinea pig av node (1991) (0)
Ranolazine Attenuates Palmitoyl‐L‐Carnitine Induced Ventricular Diastolic Dysfunction (2008) (0)
A method for the treatment of atrial fibrillation (2010) (0)
THE LATE SODIUM CURRENT INHIBITOR GS967 SUPPRESSES SPONTANEOUS ATRIAL FIBRILLATION IN AN INTACT PORCINE MODEL (2015) (0)
Ros and CaMKII Modulate Sodium Overload-Induced Calcium Leak from Ryanodine Receptors in Ventricular Myocytes (2012) (0)
SELECTIVE INHIBITION OF THE CARDIAC LATE SODIUM CURRENT WITH ELECLAZINE PROTECTS AGAINST ISCHEMIA-INDUCED ATRIAL FIBRILLATION AND VULNERABILITY TO VENTRICULAR ARRHYTHMIAS (2016) (0)
Abstract 15742: An Open-label, Multicenter Study of Flecainide Acetate Oral Inhalation Solution Shows Acute Conversion of Recent-onset, Symptomatic Atrial Fibrillation to Sinus Rhythm in a Dose- and Concentration-dependent Manner (2020) (0)
Disruption of sodium homeostasis in cardiac disease In the session on ‘ Disruption of Na + homeostasis (2015) (0)
Abstract 2562: Number of Consecutive Ectopic Beats of Non-Sustained Ventricular Tachycardia Episode Predicts Sudden Cardiac Death in Patients With Non-ST-Elevation ACS (2009) (0)
Abstract 12426: Long-term Inhibition of A2B Adenosine Receptor is Critical in Reducing Left Ventricular Remodeling and Dysfunction after Myocardial Infarction in Rat (2013) (0)
Validation of a new method for sampling human plasma in vivo (1990) (0)
A small augmentation of late sodium current markedly increases the proarrhythmic effects of very low-risk QT prolonging drugs (2005) (0)
Abstract 17029: Selective Inhibition of Late Sodium Current Suppresses Arrhythmogenic Markers in Models of Long QT Syndrome (2014) (0)
Mechanism and Physiological Implications (2005) (0)
Ventricular Microanatomy, Arrhythmias, and the Electrochemical Driving Force for Na+: Is There a Need for Flipped Learning? (2017) (0)
The use of ranolazine for the manufacture of a medicament for the treatment of arrhythmias (2003) (0)
NovelApproach forEnhancing Atrioventricular NodalConduction DelayMediated byEndogenous Adenosine (1994) (0)
Impaired AV Nodal Conduction due to AV Nodal Ischemia in Patients With Right Coronary Artery Stenosis (1998) (0)
798-2 Differential Sensitivity of AV and VA Conduction to Adenosine in Humans (1995) (0)
Abstract 11383: Glucose-Lowering Medications and Angina Burden in Patients With Stable Coronary Disease. Results From the TERISA Trial (2014) (0)
Late Na + current inhibition - finding a drug to treat diastolic heart failure (2014) (0)
Ranolazine Antagonizes The Effects Of Anemone Toxin-II On Intracellular Ca2+ Cycling In Whole Heart (2009) (0)
Rebuttal from Marc Pourrier, Sarah Williams, Donald McAfee, Luiz Belardinelli and David Fedida (2014) (0)
Abstract 12075: Whole-Genome Sequencing at 10-Days of Life in Perinatal Long-QT Syndrome Yields New Insights Into Disease Pathogenesis (2014) (0)
Abstract 9164: Low Doses of Ranolazine and Dronedarone in Combination Exert Potent Protection against Atrial Fibrillation and Vulnerability to Ventricular Arrhythmias during Acute Myocardial Ischemia (2012) (0)
Abstract 15583: GS-458967, A Selective Late Na Current Inhibitor, Effectively Improves Diastolic Function in Dahl Salt-Sensitive Rats (2013) (0)
CALL FOR PAPERS Mechanisms of Diastolic Dysfunction in Cardiovascular Disease Inhibition of late Na (cid:2) current, a novel target to improve diastolic function and electrical abnormalities in Dahl salt-sensitive rats (2016) (0)
Wound healing process using antagonists A2B adenosine receptor (2005) (0)
Use of renolazin for the manufacture of a medicament for the treatment of early after depolarizations (EADs) (2003) (0)
Abstract 360: Ca/Calmodulin Kinase II (CaMKII) Overexpression Increases Effects of Reactive Oxygen Species to Enhance Late INa and Raise [Na 3]i and [Ca 2+]i (2007) (0)
Ranolazine normalizes action potential duration in angiotensin II exposed HL-1 cells: role of late sodium current (2009) (0)
1749 AMINOPHYLLINE BUT NOT ENPROFYLLINE REVERSES NEONATAL VENTILATORY DEPRESSION CAUSED BY HYPOXIA AND L-N6-PHENYLISO-PROPYLADENOSINE (PIA) (1985) (0)
Chronotropic, dromotropic and inotropic actions of adenosine (1986) (0)
IVABRADINE CAUSES MARKED USE-DEPENDENT SLOWING OF AV NODE CONDUCTION AND REDUCES VENTRICULAR RATE DURING ATRIAL FIBRILLATION (2014) (0)
The late I Na Inhibitor Ranolazine Attenuates Effects of Palmitoyl-L-Carnitine to Increase Late I Na and Cause Ventricular Diastolic Dysfunction (2009) (0)
Adenosine: Use as a Diagnostic and Therapeutic Tool (1998) (0)
Selective Inhibition of Endogenous Late Na+ Current Stabilizes Cardiac Repolarization and Prevents Arrhythmogenicity (2013) (0)
Imaging of myocardial perfusion using adenosine receptor agonists (2004) (0)
Abstract 13468: The Expression and Role of the A2B Adenosine Receptor in Human Cardiac Myocytes (2012) (0)
I'm Sorry, Ms Jones, But We Cannot Make You Feel Better Today. (2022) (0)
Effects of Ik,Ach Channel Inhibitor Tertiapin-Q on Right Atrial Preparations from Patients in Sinus Rhythm and Atrial Fibrillation (2015) (0)
Research Article Caffeine intake induces an alteration in human neutrophil A 2A adenosine receptors (2005) (0)
Ranolazine Reduces Central Neuron Excitability by Slowly Interacting with NaV Channels (2012) (0)
Mechanisms of Diastolic Dysfunction in Cardiovascular Disease Inhibition of late Na current , a novel target to improve diastolic function and electrical abnormalities in Dahl salt-sensitive rats (2016) (0)
GS967, By Blocking the Late Sodium Current (INaL), Has Strong Action Potential–Stabilizing Properties in Isolated Remodeled Ventricular Canine Cells (2013) (0)
INTRAVENOUS RANOLAZINE RELIEVES ISCHEMIA BY INCREASING MYOCARDIAL ADENOSINE LEVELS (2015) (0)
Inhibitor Ranolazine Attenuates Effects of Palmitoyl-L-Carnitine to Increase Late INa and Cause Ventricular Diastolic Dysfunction (2009) (0)
Abstract 16882: Over Expression of Scn5a in Mouse Heart Mimics Human Syndrome of Enhanced Atrioventricular Nodal Conduction (2014) (0)
Using Patchxpress to Screen Blockers of the Cardiac Sodium Channel (Nav1.5) for Effects on Late INA, Peak INA, and Channel Kinetics (2010) (0)
Abstract 5336: Presence of Ischemia and Non-Sustained Ventricular Tachycardia is Strongly Associated With the Risk of Cardiovascular Outcomes: Observations From the MERLIN-TIMI 36 Trial (2009) (0)
Abstract 13496: Mitochondria are a Mediator of Altered Ca2+ Handling in Response to Cardiac NaI+ Overload. (2011) (0)

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