Luke O'Neill

Q: What Schools Are Affiliated With Luke O'Neill

Luke O'Neill is affiliated with the following schools: National University of Ireland, Trinity College Dublin

Luke O'Neill 's AcademicInfluence.com Rankings

Luke O'Neill

Biology

#1129

World Rank

#1933

Historical Rank

Immunology

#92

World Rank

#98

Historical Rank

biology Degrees

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Biology

Luke O'Neill 's Degrees

Bachelors Biochemistry National University of Ireland
PhD Pharmacology National University of Ireland

Why Is Luke O'Neill Influential?

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According to Wikipedia, Luke Anthony John O'Neill is an Irish biochemist. He has been a professor of biochemistry in the School of Biochemistry and Immunology at Trinity College Dublin since 2009. Early life and education O'Neill was born on 17 June 1964 in Dublin, Ireland, to Kevin O'Neill and Carmel O'Neill . He was educated at St Peter's School and Presentation College in Bray, County Wicklow, and went to Trinity College Dublin, where he was awarded an undergraduate degree in Natural Sciences in 1985. He completed his postgraduate study at the University of London, where he was awarded a PhD in pharmacology, for research investigating the characterisation of prostaglandin E2 release induced by interleukin-1 in human synovial cells, in 1988. Following his PhD, he worked at the postdoctoral researcher at the Strangeways Research Laboratory in Cambridge funded by the Medical Research Council.

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Luke O'Neill 's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling (2007) (2549)
Succinate is an inflammatory signal that induces IL-1β through HIF-1α (2013) (2359)
A guide to immunometabolism for immunologists (2016) (1720)
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases (2015) (1657)
Trained immunity: A program of innate immune memory in health and disease (2016) (1587)
Negative regulation of Toll-like receptor-mediated immune responses (2005) (1584)
The history of Toll-like receptors — redefining innate immunity (2013) (1432)
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction (2001) (1338)
mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity (2014) (1314)
Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4 (2004) (1191)
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages (2016) (1161)
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes (2010) (1141)
Metabolic reprogramming in macrophages and dendritic cells in innate immunity (2015) (1065)
Resolution of in flammation: state of the art, definitions and terms (2006) (1059)
Immunometabolism governs dendritic cell and macrophage function (2016) (1034)
NF-kB: a crucial transcription factor for glial and neuronal cell function (1997) (958)
Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21 (2010) (951)
Metabolism of inflammation limited by AMPK and pseudo-starvation (2013) (920)
Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries. (2000) (895)
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 (2018) (867)
MicroRNAs: the fine-tuners of Toll-like receptor signalling (2011) (850)
A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes (2013) (818)
TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. (2006) (778)
The Interleukin-1 Receptor/Toll-Like Receptor Superfamily: Signal Transduction During Inflammation and Host Defense (2000) (765)
Targeting Toll-like receptors: emerging therapeutics? (2010) (761)
How Toll-like receptors signal: what we know and what we don't know. (2006) (681)
Metabolic Reprograming in Macrophage Polarization (2014) (674)
Toll-like receptors: from the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity. (2006) (643)
The interleukin‐1 receptor/Toll‐like receptor superfamily: 10 years of progress (2008) (615)
Signal transduction pathways activated by the IL‐1 receptor family: ancient signaling machinery in mammals, insects, and plants (1998) (593)
Mitochondria are the powerhouses of immunity (2017) (591)
Macrophage Immunometabolism: Where Are We (Going)? (2017) (579)
ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance (2004) (561)
Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages. (2015) (553)
The Toll-IL-1 receptor adaptor family grows to five members. (2003) (540)
Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation (2006) (537)
The interleukin‐1 receptor/Toll‐like receptor superfamily: signal generators for pro‐inflammatory interleukins and microbial products (2000) (520)
Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome (2009) (519)
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis (2007) (494)
A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling. (2000) (490)
Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity. (2016) (483)
Succinate: a metabolic signal in inflammation. (2014) (434)
The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense. (2000) (428)
Circadian clock proteins and immunity. (2014) (411)
Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice (2018) (411)
Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer (2009) (410)
A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation? (2012) (403)
A guiding map for inflammation (2017) (402)
Interleukin-1β (IL-1β) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro (1996) (400)
The Poxvirus Protein A52R Targets Toll-like Receptor Signaling Complexes to Suppress Host Defense (2003) (392)
Cutting Edge: miR-223 and EBV miR-BART15 Regulate the NLRP3 Inflammasome and IL-1β Production (2012) (381)
NF-kappa B: a crucial transcription factor for glial and neuronal cell function. (1997) (377)
BCG-induced trained immunity: can it offer protection against COVID-19? (2020) (369)
NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components (2012) (354)
T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells (2016) (352)
When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction. (2008) (349)
Signalling adaptors used by Toll-like receptors: an update. (2008) (346)
Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages. (2015) (343)
Myocardial Ischemia/Reperfusion Injury Is Mediated by Leukocytic Toll-Like Receptor-2 and Reduced by Systemic Administration of a Novel Anti–Toll-Like Receptor-2 Antibody (2010) (333)
miR‐223: infection, inflammation and cancer (2013) (333)
Genetic variation in Toll-like receptors and disease susceptibility (2012) (332)
Human polymorphism at microRNAs and microRNA target sites. (2013) (330)
Signal transduction pathways activated by the IL-1 receptor/toll-like receptor superfamily. (2002) (312)
HIF1α and metabolic reprogramming in inflammation. (2016) (309)
Localisation and trafficking of Toll-like receptors: an important mode of regulation. (2010) (307)
Reprogramming mitochondrial metabolism in macrophages as an anti‐inflammatory signal (2016) (306)
A trio of microRNAs that control Toll-like receptor signalling. (2011) (305)
IL-1 family nomenclature (2010) (302)
A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation (2018) (297)
Human Tribbles, a Protein Family Controlling Mitogen-activated Protein Kinase Cascades* (2004) (293)
Vitamin C Inhibits NF-κB Activation by TNF Via the Activation of p38 Mitogen-Activated Protein Kinase1 (2000) (290)
Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice (2017) (288)
New insights into the regulation of TLR signaling (2006) (275)
Targeting signal transduction as a strategy to treat inflammatory diseases (2006) (273)
The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. (2006) (270)
Itaconate: the poster child of metabolic reprogramming in macrophage function (2019) (260)
IL-10 Inhibits miR-155 Induction by Toll-like Receptors* (2010) (260)
Role for NLRP3 Inflammasome‐mediated, IL‐1&bgr;‐Dependent Responses in Severe, Steroid‐Resistant Asthma (2017) (258)
Bruton's Tyrosine Kinase Is a Toll/Interleukin-1 Receptor Domain-binding Protein That Participates in Nuclear Factor κB Activation by Toll-like Receptor 4* (2003) (254)
Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome (2017) (252)
Adding fuel to fire: microRNAs as a new class of mediators of inflammation (2008) (249)
The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype. (2016) (239)
Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages* (2015) (232)
Structural Complementarity of Toll/Interleukin-1 Receptor Domains in Toll-like Receptors and the Adaptors Mal and MyD88* (2003) (229)
Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated? (2008) (224)
Annotating genes with potential roles in the immune system: six new members of the IL-1 family. (2001) (224)
Effects of oxidants and antioxidants on nuclear factor kappa B activation in three different cell lines: evidence against a universal hypothesis involving oxygen radicals. (1995) (224)
NLRP3 at the interface of metabolism and inflammation (2015) (224)
Structure, function and regulation of the Toll/IL‐1 receptor adaptor proteins (2007) (223)
Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1 (2015) (220)
MyD88 Adapter-like (Mal) Is Phosphorylated by Bruton's Tyrosine Kinase during TLR2 and TLR4 Signal Transduction* (2006) (220)
Monounsaturated Fatty Acid–Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome–Mediated IL-1β Secretion and Insulin Resistance Despite Obesity (2015) (216)
Coupling Krebs cycle metabolites to signalling in immunity and cancer (2018) (215)
The Toll/interleukin-1 receptor domain: a molecular switch for inflammation and host defence. (2000) (215)
The interferon in TLR signaling: more than just antiviral. (2003) (213)
Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication (2016) (208)
Interleukin 1 induces NF-kappa B through its type I but not its type II receptor in lymphocytes. (1992) (203)
Activated protein C inhibits lipopolysaccharide‐induced nuclear translocation of nuclear factor κB (NF‐κB) and tumour necrosis factor α (TNF‐α) production in the THP‐1 monocytic cell line (2000) (201)
A Dimer of the Toll-Like Receptor 4 Cytoplasmic Domain Provides a Specific Scaffold for the Recruitment of Signalling Adaptor Proteins (2007) (199)
Lipid Peroxidation Is Involved in the Activation of NF-κB by Tumor Necrosis Factor but Not Interleukin-1 in the Human Endothelial Cell Line ECV304 (1997) (197)
Innate immune memory: a paradigm shift in understanding host defense (2015) (196)
Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments. (2013) (195)
How Metabolism Generates Signals during Innate Immunity and Inflammation* (2013) (191)
Targeting immunometabolism as an anti-inflammatory strategy (2020) (190)
Sensing and Signaling in Antiviral Innate Immunity (2010) (188)
Metabolic regulation of NLRP3 (2018) (180)
What the Myddosome structure tells us about the initiation of innate immunity. (2011) (173)
How important are Toll‐like receptors for antimicrobial responses? (2007) (172)
Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2 (2018) (172)
The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation (2020) (171)
A Role for TLR4 in Clostridium difficile Infection and the Recognition of Surface Layer Proteins (2011) (171)
Adaptor usage and Toll‐like receptor signaling specificity (2005) (168)
Signalling of toll-like receptors. (2008) (168)
Trained immunity, tolerance, priming and differentiation: distinct immunological processes (2020) (168)
Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4. (2003) (167)
Toll-like receptor signal transduction and the tailoring of innate immunity: a role for Mal? (2002) (165)
Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins. (2009) (164)
TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88–independent TLR4 pathway (2009) (161)
Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases. (2003) (160)
The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction. (2004) (160)
Krebs Cycle Reborn in Macrophage Immunometabolism. (2020) (159)
Inflammasomes in inflammatory disorders: the role of TLRs and their interactions with NLRs (2007) (157)
TLRs: Professor Mechnikov, sit on your hat. (2004) (154)
The Inflammasome in Atherosclerosis and Type 2 Diabetes (2011) (152)
The Cellular and Molecular Basis of Translational Immunometabolism. (2015) (152)
Interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro. (1996) (151)
TLR9 Provokes Inflammation in Response to Fetal DNA: Mechanism for Fetal Loss in Preterm Birth and Preeclampsia (2012) (148)
A broken krebs cycle in macrophages. (2015) (145)
Toll-like receptors and chronic inflammation in rheumatic diseases: new developments (2016) (143)
New developments in Toll-like receptor targeted therapeutics. (2012) (142)
Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming (2018) (142)
Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling. (2006) (141)
Bruton's Tyrosine Kinase Is Involved in p65-mediated Transactivation and Phosphorylation of p65 on Serine 536 during NFκB Activation by Lipopolysaccharide* (2005) (140)
Inhibition of nuclear factor kappaB by direct modification in whole cells--mechanism of action of nordihydroguaiaritic acid, curcumin and thiol modifiers. (1998) (140)
New Insights into the Regulation of Signalling by Toll-Like Receptors and Nod-Like Receptors (2010) (136)
The Evolution of the MAP Kinase Pathways: Coduplication of Interacting Proteins Leads to New Signaling Cascades (1999) (135)
Crystal Structure of the Toll/Interleukin-1 Receptor Domain of Human IL-1RAPL* (2004) (133)
The Role of HIF in Immunity and Inflammation. (2020) (131)
Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity (2019) (131)
Signaling by Toll-like Receptors 8 and 9 Requires Bruton's Tyrosine Kinase* (2007) (131)
The role of MyD88-like adapters in Toll-like receptor signal transduction. (2003) (130)
The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes (2011) (127)
Studies into the Effect of the Tyrosine Kinase Inhibitor Herbimycin A on NF-κB Activation in T Lymphocytes EVIDENCE FOR COVALENT MODIFICATION OF THE p50 SUBUNIT (*) (1995) (127)
NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1 (2007) (126)
Towards an understanding of the signal transduction pathways for interleukin 1. (1995) (126)
Disease-associated amyloid and misfolded protein aggregates activate the inflammasome. (2011) (125)
Biochemical regulation of the inflammasome (2012) (124)
The Murine Irak2 Gene Encodes Four Alternatively Spliced Isoforms, Two of Which Are Inhibitory* (2004) (121)
Building an immune system from nine domains. (2007) (120)
Mal Interacts with Tumor Necrosis Factor Receptor-associated Factor (TRAF)-6 to mediate NF-κB Activation by Toll-like Receptor (TLR)-2 and TLR4* (2004) (120)
Ras, Protein Kinase Cζ, and IκB Kinases 1 and 2 Are Downstream Effectors of CD44 During the Activation of NF-κB by Hyaluronic Acid Fragments in T-24 Carcinoma Cells1 (2000) (119)
A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia. (2018) (119)
The Anti-inflammatory Cytokine, Interleukin (IL)-10, Blocks the Inhibitory Effect of IL-1β on Long Term Potentiation (2001) (117)
Daunorubicin Activates NFκB and Induces κB-dependent Gene Expression in HL-60 Promyelocytic and Jurkat T Lymphoma Cells* (1997) (115)
An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation (2018) (115)
Ras Participates in the Activation of p38 MAPK by Interleukin-1 by Associating with IRAK, IRAK2, TRAF6, and TAK-1* (2002) (114)
Inflammasomes in the lung (2017) (111)
Activation of NF-kappa B and induction of vascular cell adhesion molecule-1 and intracellular adhesion molecule-1 expression in human glial cells by IL-1. Modulation by antioxidants. (1994) (110)
MyD88 Adaptor-Like Is Not Essential for TLR2 Signaling and Inhibits Signaling by TLR31 (2009) (109)
The Immunomodulatory Potential of the Metabolite Itaconate. (2019) (107)
MicroRNAs and the resolution phase of inflammation in macrophages (2011) (104)
Toll‐like receptors: key activators of leucocytes and regulator of haematopoiesis (2007) (103)
Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors (2017) (103)
Primer: Toll-like receptor signaling pathways—what do rheumatologists need to know? (2008) (102)
Characterization of Signaling Pathways Activated by the Interleukin 1 (IL-1) Receptor Homologue T1/ST2 (2002) (100)
Malonylation of GAPDH is an inflammatory signal in macrophages (2019) (99)
Treatment With OPN-305, a Humanized Anti–Toll-Like Receptor-2 Antibody, Reduces Myocardial Ischemia/Reperfusion Injury in Pigs (2012) (99)
Interferon Regulatory Factor-3-mediated Activation of the Interferon-sensitive Response Element by Toll-like receptor (TLR) 4 but Not TLR3 Requires the p65 Subunit of NF-κ* (2003) (99)
Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock (2009) (98)
Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy (2017) (98)
Modulation of Innate and Acquired Immune Responses by Escherichia coli Heat-Labile Toxin: Distinct Pro- and Anti-Inflammatory Effects of the Nontoxic AB Complex and the Enzyme Activity1 (2000) (98)
Krebs cycle rewired for macrophage and dendritic cell effector functions (2017) (93)
A critical role for citrate metabolism in LPS signalling. (2011) (92)
Rac1 Regulates Interleukin 1-induced Nuclear Factor κB Activation in an Inhibitory Protein κBα-independent Manner by Enhancing the Ability of the p65 Subunit to Transactivate Gene Expression* (2000) (91)
Cytokine-like Roles for Metabolites in Immunity. (2020) (89)
The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome (2017) (88)
IMMUNOLOGY: After the Toll Rush (2004) (87)
The Role of Ets2 Transcription Factor in the Induction of MicroRNA-155 (miR-155) by Lipopolysaccharide and Its Targeting by Interleukin-10* (2013) (85)
Tyrosine Phosphorylation of MyD88 Adapter-like (Mal) Is Critical for Signal Transduction and Blocked in Endotoxin Tolerance* (2008) (83)
Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction (2014) (82)
Interleukin-1 activates transcription factor NF kappa B in glial cells. (1993) (81)
miR‐107: a Toll‐like receptor‐regulated miRNA dysregulated in obesity and type II diabetes (2012) (81)
Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures (2011) (80)
The role of the interleukin-1/Toll-like receptor superfamily in inflammation and host defence. (2000) (80)
Transactivation by the p65 Subunit of NF-κB in Response to Interleukin-1 (IL-1) Involves MyD88, IL-1 Receptor-Associated Kinase 1, TRAF-6, and Rac1 (2001) (80)
Tribbles 3: A Novel Regulator of TLR2-Mediated Signaling in Response to Helicobacter pylori Lipopolysaccharide (2011) (79)
Listeria monocytogenes infection in the face of innate immunity (2009) (79)
Bruton's tyrosine kinase (Btk)-the critical tyrosine kinase in LPS signalling? (2004) (78)
Toll-like receptors and NOD-like receptors in rheumatic diseases (2009) (78)
Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors (2003) (77)
Schlafen-1 Causes a Cell Cycle Arrest by Inhibiting Induction of Cyclin D1* (2005) (77)
The impact of childhood obesity on inflammation, innate immune cell frequency, and metabolic microRNA expression. (2014) (77)
Characterization of CD44 induction by IL-1: a critical role for Egr-1. (1999) (76)
Protective Role for Caspase-11 during Acute Experimental Murine Colitis (2014) (75)
The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling (2007) (74)
Cellular Proliferation and Activation of NFκB Are Induced by Autocrine Production of Tumor Necrosis Factor α in the Human T Lymphoma Line HuT 78 (*) (1995) (74)
Oxidative stress and nuclear factor-κB activation (2000) (74)
The role of toll-like receptors in macrophages. (2008) (73)
Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease (2017) (71)
The emerging role of metabolic regulation in the functioning of Toll‐like receptors and the NOD‐like receptor Nlrp3 (2011) (71)
Divergent Roles for Ras and Rap in the Activation of p38 Mitogen-activated Protein Kinase by Interleukin-1* (2000) (71)
Internalin B Activates Nuclear Factor-κB via Ras, Phosphoinositide 3-Kinase, and Akt* (2001) (70)
IL‐1F5 mediates anti‐inflammatory activity in the brain through induction of IL‐4 following interaction with SIGIRR/TIR8 (2008) (69)
Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation (2017) (67)
The Induction of Pro–IL-1β by Lipopolysaccharide Requires Endogenous Prostaglandin E2 Production (2017) (67)
Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide. (2005) (66)
Mal Mediates TLR-Induced Activation of CREB and Expression of IL-10 (2011) (65)
Glucocorticoids Inhibit IRF3 Phosphorylation in Response to Toll-like Receptor-3 and -4 by Targeting TBK1 Activation* (2008) (64)
Diversity and regulation in the NF-κB system (2007) (62)
Both TLR2 and TRIF Contribute to Interferon-β Production during Listeria Infection (2012) (60)
Toll-like Receptor-4 (TLR4) Down-regulates MicroRNA-107, Increasing Macrophage Adhesion via Cyclin-dependent Kinase 6* (2011) (59)
NLRP3 and IL‐1β in macrophages as critical regulators of metabolic diseases (2013) (58)
The serine protease inhibitor antithrombin III inhibits LPS‐mediated NF‐κB activation by TLR‐4 (2001) (58)
Specific Inhibition of the NLRP3 Inflammasome as an Anti-Inflammatory Strategy in Cystic Fibrosis. (2019) (58)
The Interleukin-1 Receptor/Toll-Like Receptor Superfamily (2003) (58)
IRAK1 and IRAK4 Promote Phosphorylation, Ubiquitination, and Degradation of MyD88 Adaptor-like (Mal)* (2010) (57)
How Frustration Leads to Inflammation (2008) (57)
Glutathione transferase omega 1 is required for the lipopolysaccharide-stimulated induction of NADPH oxidase 1 and the production of reactive oxygen species in macrophages. (2014) (57)
Mass Spectrometric Analysis of the Endogenous Type I Interleukin-1 (IL-1) Receptor Signaling Complex Formed after IL-1 Binding Identifies IL-1RAcP, MyD88, and IRAK-4 as the Stable Components* (2007) (56)
Interleukin-1 signal transduction. Increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4). (1990) (55)
The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation (2012) (55)
Ceramide Activates NFκB by Inducing the Processing of p105* (1998) (54)
Regulators of TLR4 signaling by endotoxins. (2010) (51)
TRIL, a Functional Component of the TLR4 Signaling Complex, Highly Expressed in Brain1 (2009) (51)
Immunometabolism and atherosclerosis: perspectives and clinical significance- A position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology. (2019) (51)
Topoisomerase II Is Required for Mitoxantrone to Signal Nuclear Factor κB Activation in HL60 Cells* (2000) (49)
TILRR, a Novel IL-1RI Co-receptor, Potentiates MyD88 Recruitment to Control Ras-dependent Amplification of NF-κB* (2009) (49)
Modification of Proteins by Metabolites in Immunity. (2020) (49)
Bruton’s Tyrosine Kinase Mediates the Synergistic Signalling between TLR9 and the B Cell Receptor by Regulating Calcium and Calmodulin (2013) (48)
A p38 MAP kinase inhibitor SB203580 inhibits CD28-dependent T cell proliferation and IL-2 production. (1997) (48)
TLRs play good cop, bad cop in the lung (2005) (47)
LPS Induces the Degradation of Programmed Cell Death Protein 4 (PDCD4) to Release Twist2, Activating c-Maf Transcription to Promote Interleukin-10 Production* (2014) (47)
The role of itaconate in host defense and inflammation (2022) (46)
GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway (2015) (46)
Mal, more than a bridge to MyD88 (2013) (46)
The potential of targeting Toll-like receptor 2 in autoimmune and inflammatory diseases (2007) (45)
Genetic Variation in Toll-Like Receptor Signalling and the Risk of Inflammatory and Immune Diseases (2009) (45)
Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa. (2003) (45)
Sensing the Dark Side of DNA (2013) (44)
High-resolution structure of murine interleukin 1 homologue IL-1F5 reveals unique loop conformations for receptor binding specificity. (2003) (44)
Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation. (2019) (44)
The circadian protein BMAL1 in myeloid cells is a negative regulator of allergic asthma. (2017) (43)
Genetic Variation of Innate Immune Genes in HIV-Infected African Patients With or Without Oropharyngeal Candidiasis (2010) (43)
Questions and controversies in innate immune research: what is the physiological role of NLRP3? (2016) (43)
The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome (2017) (43)
The Mal/TIRAP S180L and TLR4 G299D polymorphisms are not associated with susceptibility to, or severity of, rheumatoid arthritis (2007) (43)
A Potent Anti-Inflammatory Response in Bat Macrophages May Be Linked to Extended Longevity and Viral Tolerance (2017) (43)
SIGIRR puts the brakes on Toll-like receptors (2003) (43)
A 46 R and A 52 R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling (2000) (42)
'Fine tuning' TLR signaling (2008) (42)
Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion (2016) (42)
Distinct roles for p42/p44 and p38 mitogen-activated protein kinases in the induction of IL-2 by IL-1. (1999) (40)
Diversity and regulation in the NF-kappaB system. (2007) (40)
Glycolytic reprogramming by TLRs in dendritic cells (2014) (40)
Detecting microRNA activity from gene expression data (2010) (40)
TAMpering with Toll-like Receptor Signaling (2007) (39)
Trif-related adapter molecule is phosphorylated by PKC during Toll-like receptor 4 signaling (2006) (39)
Loss of MicroRNA-21 Influences the Gut Microbiota, Causing Reduced Susceptibility in a Murine Model of Colitis (2018) (38)
The role of microRNAs in the control and mechanism of action of IL-10. (2014) (38)
Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL‐1β (2019) (37)
The MyD88+ Phenotype Is an Adverse Prognostic Factor in Epithelial Ovarian Cancer (2014) (37)
Topoisomerase II is required for mitoxantrone to signal nuclear factor kappa B activation in HL60 cells. (2000) (36)
Caspase-11 promotes allergic airway inflammation (2020) (36)
The production of a reactive oxygen intermediate during the induction of apoptosis by cytotoxic insult. (1998) (36)
TIRAP Ser180Leu polymorphism is associated with Behcet's disease. (2011) (35)
Rab39a Binds Caspase-1 and Is Required for Caspase-1-dependent Interleukin-1β Secretion* (2009) (35)
Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling (2017) (35)
Interleukin-1 potentiates bradykinin- and TNFα-induced PGE2 release (1989) (35)
Camelpox virus encodes a schlafen-like protein that affects orthopoxvirus virulence (2007) (35)
Evidence against a role for NLRP3-driven islet inflammation in db/db mice (2018) (34)
MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C (2013) (33)
GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity (2017) (33)
Boosting the brain's ability to block inflammation via microRNA-132. (2009) (33)
Toll-like Receptor 3 (TLR3) Signaling Requires TLR4 Interactor with Leucine-rich Repeats (TRIL)* (2011) (32)
Immunity's early-warning system. (2005) (32)
IκB Kinase ϵ Interacts with p52 and Promotes Transactivation via p65* (2006) (32)
MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection (2017) (31)
The GOLD Domain-containing Protein TMED1 Is Involved in Interleukin-33 Signaling* (2013) (31)
Interleukin-1 signal transduction (1995) (31)
Succinate is a danger signal that induces IL-1β via HIF-1α (2014) (31)
DNA Makes RNA Makes Innate Immunity (2009) (31)
A Metabolic Roadblock in Inflammatory Macrophages. (2016) (29)
A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling (2016) (29)
Signalling via CD28 of human naive neonatal T lymphocytes (1995) (29)
A novel function of InlB from Listeria monocytogenes: activation of NF‐κB in J774 macrophages (2000) (29)
Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1β and Tumor Necrosis Factor α (2013) (28)
Influenza A virus causes maternal and fetal pathology via innate and adaptive vascular inflammation in mice (2020) (27)
Toll-like receptors in inflammation (2005) (26)
Rehabilitation strategies following esophageal cancer (the ReStOre trial): a feasibility study (2017) (26)
Molecular Mechanisms Underlying the Actions of the Pro-inflammatory Cytokine Interleukin I (1997) (25)
Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene. (2004) (25)
Inhibitory effects of diclofenac and indomethacin on interleukin-1-induced changes in PGE2 release. A novel effect on free arachidonic acid levels in human synovial cells. (1989) (24)
The role of the electron transport chain in immunity (2021) (24)
Mycobacterial PIMs Inhibit Host Inflammatory Responses through CD14-Dependent and CD14-Independent Mechanisms (2011) (24)
Rab39a Binds Caspase-1 and Is Required for Caspase-1-dependent Interleukin-1β Secretion* (2009) (23)
The Powerstroke and Camshaft of the RIG-I Antiviral RNA Detection Machine (2011) (23)
Targeting immunometabolism to treat COVID-19 (2021) (22)
Cardiolipin and the Nlrp3 inflammasome. (2013) (22)
Desferrioxamine Supports Metabolic Function in Primary Human Macrophages Infected With Mycobacterium tuberculosis (2020) (22)
Regulation of Signaling by Non-degradative Ubiquitination* (2009) (21)
Extracts of feverfew inhibit mitogen-induced human peripheral blood mononuclear cell proliferation and cytokine mediated responses: a cytotoxic effect. (1987) (21)
Interleukin-1 receptor-associated kinase and TRAF-6 mediate the transcriptional regulation of interleukin-2 by interleukin-1 via NFkappaB but unlike interleukin-1 are unable to stabilise interleukin-2 mRNA. (1999) (21)
MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice. (2014) (21)
Dimethyl fumarate: targeting glycolysis to treat MS (2018) (21)
TCA cycle signalling and the evolution of eukaryotes. (2020) (21)
Low pH and Helicobacter pylori increase nuclear factor kappa B binding in gastric epithelial cells: A common pathway for epithelial cell injury? (2005) (20)
How NOD-ing off leads to Crohn disease (2004) (20)
How Low Cholesterol Is Good for Anti-viral Immunity (2015) (19)
Wanted: a molecular basis for specificity in toll-like receptor signal transduction. (2002) (18)
TRIL Is Involved in Cytokine Production in the Brain following Escherichia coli Infection (2014) (18)
The binding subunit of pertussis toxin inhibits IL-1 induction of IL-2 and prostaglandin production. (1992) (18)
Metabolic regulation of RA macrophages is distinct from RA fibroblasts and blockade of glycolysis alleviates inflammatory phenotype in both cell types (2021) (17)
Glutathione and Glutathione Transferase Omega 1 as Key Posttranslational Regulators in Macrophages. (2017) (17)
A method to predict residues conferring functional differences between related proteins: Application to MAP kinase pathways (2008) (17)
Toll-like receptors in cancer (2008) (17)
Innate Immunity: Squelching Anti-Viral Signalling with NLRX1 (2008) (17)
TNF-mediated cytotoxicity of L929 cells: role of staurosporine in enhancement of cytotoxicity and translocation of protein kinase C isozymes. (1997) (16)
Toll-like receptors in the spotlight (2003) (16)
Daily variation in macrophage phagocytosis is clock‐independent and dispensable for cytokine production (2019) (16)
IRAK-4: a new drug target in inflammation, sepsis, and autoimmunity. (2002) (15)
Biochemistry: Succinate strikes (2014) (15)
Promyelocytic Leukemia Protein Interacts with the Apoptosis-associated Speck-like Protein to Limit Inflammasome Activation* (2014) (14)
Specificity in the innate response: pathogen recognition by Toll-like receptor combinations. (2001) (14)
How should we talk about metabolism? (2020) (14)
Bacteria fight back against Toll-like receptors (2008) (14)
Interleukin-1 and phorbol myristate acetate modulate the peripheral-type benzodiazepine receptor in lymphocytes and glial cells. (1993) (14)
Spatial Properties of Reactive Oxygen Species Govern Pathogen-Specific Immune System Responses (2020) (14)
RAB39a binds caspase-1 and is required for caspase-1-dependent interleukin-1β secretion. (2016) (14)
How does interleukin-1 activate cells? (1992) (13)
“Transflammation”: When Innate Immunity Meets Induced Pluripotency (2012) (13)
Nuclear Factor κB2 p52 Protein Has a Role in Antiviral Immunity through IκB Kinase ϵ-dependent Induction of Sp1 Protein and Interleukin 15* (2013) (13)
Interferon Regulatory Factor-3-mediated Activation of the Interferon-sensitive Response Element by Toll-like receptor ( TLR ) 4 but Not TLR 3 Requires the p 65 Subunit of NF-B * (2003) (13)
Outfoxing Foxo1 with miR-182 (2010) (12)
Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells. (1997) (12)
34: LincRNA-Cox2 is a long noncoding RNA induced by TLRs that mediates both activation and repression of immune response genes (2013) (12)
Glucocorticoids Inhibit IRF 3 Phosphorylation in Response to Toll-like Receptor-3 and-4 by Targeting TBK 1 Activation * (2008) (12)
ACLY Nuclear Translocation in Human Macrophages Drives Proinflammatory Gene Expression by NF-κB Acetylation (2021) (11)
4-Octyl-itaconate and dimethyl fumarate inhibit COX2 expression and prostaglandin production in macrophages (2021) (11)
RAB39A BINDS CASPASE-1 AND IS REQUIRED FOR CASPASE-1-DEPENDENT IL-1β SECRETION (2009) (11)
DisSARMing Toll-like receptor signaling (2006) (11)
Inhibition of NF kappa B activity by oxidative processes in intact cells mechanism of action of pyrolidine dithiocarbamate and diamide. (1996) (11)
A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis (2014) (11)
Conjugated linoleic acid suppresses IRF3 activation via modulation of CD14. (2013) (11)
MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction. (2016) (11)
Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages (2021) (11)
GOTcha: lncRNA-ACOD1 targets metabolism during viral infection (2017) (11)
Choice of SARS-CoV-2 diagnostic test: challenges and key considerations for the future (2022) (11)
Interleukin-1 potentiates bradykinin- and TNF alpha-induced PGE2 release. (1989) (11)
A randomized controlled trial protocol assessing the effectiveness, safety and cost‐effectiveness of methotrexate vs. ciclosporin in the treatment of severe atopic eczema in children: the TREatment of severe Atopic eczema Trial (TREAT) (2018) (11)
VITAMIN C INHIBITS NFκB ACTIVATION IN ENDOTHELIAL CELLS (1997) (10)
Interleukin I receptors and signal transduction. (1996) (10)
SARS-CoV-2 targets MAVS for immune evasion (2021) (10)
Immune-mediated inflammation across disease boundaries: breaking down research silos (2021) (10)
Role for Retinoic Acid-Related Orphan Receptor Alpha (RORα) Expressing Macrophages in Diet-Induced Obesity (2020) (10)
A feed-forward loop involving hyaluronic acid and toll-like receptor-4 as a treatment for colitis? (2009) (9)
New insights into the post-translational modification of Toll-like receptor signaling molecules (2005) (9)
ACLY-matizing Macrophages to Histone Modification during Immunometabolic Reprogramming. (2020) (9)
Relationship between type 2 cytokine and inflammasome responses in obesity-associated asthma. (2021) (9)
Repurposing mitochondria from ATP production to ROS generation drives a pro-inflammatory phenotype in macrophages that depends on succinate oxidation by complex II (2018) (9)
Toll-like receptors and the danger hypothesis. (2001) (8)
Innate Immunity in Plants Goes to the PUB (2011) (8)
IL-1 signal transduction: evidence of activation of G protein and protein kinase. (1990) (8)
Gob genes, mucus and asthma. (2001) (7)
IL-1 versus TNF in arthritis? (2001) (7)
Evidence for direct modification of NF kappa B by the tyrosine kinase inhibitor, herbimycin A. (1995) (7)
Is Citrate A Critical Signal in Immunity and Inflammation? (2020) (7)
Vitamin C inhibits NF kappa B activation in endothelial cells. (1997) (7)
Macrophages Remember Cheeseburgers and Promote Inflammation via NLRP3. (2018) (7)
How does interleukin 1 activate cells? Interleukin 1 signal transduction. (1990) (7)
Autocrine regulation of the transcription factor NFκB by TNFα in the human T cell lymphoma line Hut 78 (1995) (7)
The Interleukin-1 Receptor/Toll-like Receptor Superfamily: Signal Transduction During Inflammation and Host Defense (2000) (7)
Irish say no to Nice but yes to immunology. (2001) (6)
Synergism between NOD-like receptors and Toll-like receptors in human B lymphocytes. (2011) (6)
Immunometabolism and the land of milk and honey (2017) (6)
The role of MyD 88-like adapters in Toll-like receptor signal transduction (2003) (6)
Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1. (2016) (6)
Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants. (2022) (6)
Mechanism of NFκB activation by interleukin-1 and tumour necrosis factor in endothelial cells (1996) (6)
Endothelin‐1 Increases Arachidonic Acid Release in C6 Glioma Cells Through a Potassium‐Modulated Influx of Calcium (1996) (6)
Altered inflammasome activation in neonatal encephalopathy persists in childhood (2021) (6)
Evidence for a redox-sensitive protein tyrosine kinase in nuclear factor kappa B activation and interleukin 2 production in EL4.NOB1 cells. (1993) (6)
MyD88 is an essential component of retinoic acid-induced differentiation in human pluripotent embryonal carcinoma cells (2017) (5)
The effects of thiol modifiers on the activation of NFκB by interleukin-1 (1993) (5)
Canakinumab for Atherosclerotic Disease. (2018) (5)
A role for leptin in autoimmunity? (2001) (5)
Modulation of Toll-Like Receptor Signalling as a New Therapeutic Principle (2011) (5)
Interleukin 1 signalling: synergy with Rac1 and Pi3 kinase. (1997) (5)
Effect of interleukin-1 on free arachidonic acid levels in human synovial cells (1988) (5)
Counter-regulation in the IKK family. (2011) (5)
Regulation of T cell activation and pathogenicity by dimeric pyruvate kinase M2 (PKM2) (2019) (5)
Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes (2021) (5)
Innate immune signaling and immunothrombosis: New insights and therapeutic opportunities (2022) (5)
Microarray analysis reveals osteopontin as important player in MS (2002) (4)
Studies into the mechanism of NF kappa B activation by IL1, TNF and H2O2 in primary and transformed endothelial cells. (1997) (4)
Metabolic Reprogramming of the Cystic Fibrosis Neutrophil Drives Interleukin-1β via the NLRP3 Inflammasome (2019) (4)
Spotlight on new anti-inflammatory drug targets in the immune system. (2003) (4)
Targeting mitochondria to beat HIV-1 (2021) (4)
The NLRP3 inhibitor MCC950 inhibits IL-1β production in PBMC from 19 patients with Cryopyrin-Associated Periodic Syndrome and in 2 patients with Schnitzler’s Syndrome (2020) (4)
Molecular mechanisms underlying the actions of the pro-inflammatory cytokine interleukin 1. Royal Irish Academy Medal Lecture. (1997) (4)
Caspase-4: A Therapeutic Target for Peptic Ulcer Disease (2020) (4)
Activation of NF kappa B and potentiation of TNF-induced NF kappa B activation by ceramide analogues in leukemic cell lines despite the absence of an observed sphingomyelinase signalling event. (1996) (4)
Mechanism of NF kappa B activation by interleukin-1 and tumour necrosis factor in endothelial cells. (1996) (4)
Stopping Sepsis by Targeting Sphingosine Kinase 1 (2010) (4)
Sulfonylureas and related compounds and use of the same (2016) (4)
The immune system as an invisible, silent Grand Fugue (2009) (3)
Co-stimulating allergy. (2001) (3)
Proteolysis of the zona pellucida of mouse ova. (1990) (3)
Differential stimulation of IL-6 secretion following apical and basolateral presentation of IL-1 on epithelial cell lines. (1996) (3)
Editorial: Synergism between NOD‐like receptors and Toll‐like receptors in human B lymphocytes (2011) (3)
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production (2023) (3)
The TREatment of severe Atopic eczema Trial (TREAT) (2018) (3)
How neutrophil metabolism affects bacterial killing (2022) (3)
Itaconate inhibits alternative activation of macrophages by targeting Janus Kinase 1 (2019) (3)
The itaconate family of immunomodulators grows (2022) (3)
Pseudomonas Persists by Feeding off Itaconate. (2020) (2)
The human endothelial cell line ECY304 as a model of endothelial cell activation by interleukin-1. (1995) (2)
Erratum: IL-1 family nomenclature (2011) (2)
mRNA Degradation: an Important Process in Controlling Gene Expression (2002) (2)
32 ACTIVATION OF REDOX-SENSITIVE INFLAMMASOMES UNDERLIES THE BIOLOGICAL PHENOTYPE OF MYELODYSPLASTIC SYNDROMES (2015) (2)
lnterleukin-1 activates transcription factor NFKB in glial cells (2005) (2)
Author Correction: A guiding map for inflammation (2020) (2)
Dioxins damage dendritic cells (2001) (2)
Transcriptional regulation of the human TRIF ( TIR domain-containing adaptor protein inducing interferon β ) gene (2004) (2)
Two for the price of one: itaconate and its derivatives as an anti-infective and anti-inflammatory immunometabolite. (2022) (2)
IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal). (2016) (2)
Can NLRP3 inhibitors improve on dexamethasone for the treatment of COVID-19? (2021) (2)
A Vision for Cytokine Biology with 20/20 Clarity (2020) (2)
Bridging the gap – a new role for STAT3 in TLR4‐mediated metabolic reprogramming (2020) (2)
The Trypanosome-Derived Metabolite Indole-3-Pyruvate Inhibits Prostaglandin Production in Macrophages by Targeting COX2 (2021) (2)
Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy (2017) (2)
Jürg Tschopp (1951–2011) (2011) (2)
Crohn's disease gene is given the NOD. (2001) (2)
Autocrine regulation of the transcription factor NF kappa B by TNF alpha in the human T cell lymphoma line Hut 78. (1995) (2)
Using immunotherapy to treat rheumatic diseases. (2002) (2)
Pyruvate KinaseM 2 Regul ates Hif-1 a Activity and IL-1 b Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages Graphical Abstract Highlights (2015) (2)
Monounsaturated Fatty Acid High‐Fat Diets Impede Adipose IL‐1β Secretion and Insulin Resistance (2015) (2)
Not All Mitochondrial Cristae Are the Same: Hetero-Potential in the Inner Mitochondrial Membrane (2019) (2)
Innate immunity and Toll-like receptors (2004) (2)
THU0027 The Effect of Novel Compound Mcc950 on the Nlrp3 Inflammasome in the RA Joint (2015) (2)
Mechanisms of signal transduction and inducible gene expression by the Toll/IL-1 receptor superfamily (2004) (2)
The Hunger Games: Salmonella, Anorexia, and NLRP3. (2017) (2)
Targeting macrophage immunometabolism to prevent atherosclerosis (2019) (2)
The MyD 88 + Phenotype Is an Adverse Prognostic Factor in Epithelial Ovarian Cancer (2014) (2)
Glutathione Transferase Omega 1 confers protection against azoxymethane-induced colorectal tumour formation. (2021) (2)
A6.18 Novel compound cytokine release inhibitory drug 3 (CRID3) inhibits the NLRP3 inflammasome in rheumatoid arthritis (2015) (2)
A renaissance of interest in innate immunity: will new treatments for rheumatoid arthritis emerge? (2008) (2)
IKK EPSILON INTERACTS WITH p52 AND PROMOTES TRANSACTIVATION VIA p65 (2006) (1)
Fixing a broken heart with bone (2001) (1)
Negative Regulators of NF-κB Activation and Type I Interferon Pathways (2012) (1)
Immunometabolism pathways as the basis for innovative anti-viral strategies (INITIATE): A Marie Sklodowska-Curie innovative training network (2020) (1)
miRNAs That Shape the Innate Immune System: Regulation through Toll-Like Receptor Signaling (2013) (1)
Effect of anti-rheumatic drugs on interleukin 1 activity in human synovial cells (1988) (1)
Reply to ”Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations” (2008) (1)
PL-1 The IL-1 receptor/Toll-like receptor superfamily: 10 Years of progress (2008) (1)
Toll-Like Receptors (2009) (1)
100 NF-κB Activation by Mal/Tirap is Regulated by Caspase-1 (2007) (1)
Autocrine NLRP3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-gamma in CD4+T cells (2016) (1)
Sustained activation of NF kappa B and transient I kappa B alpha degradation induced by tumour necrosis factor in 1321N1 human astrocytoma. (1995) (1)
Induction of the adhesion molecule CD44 by the pro-inflammatory cytokine interleukin-1 in endothelial cells. (1997) (1)
Correction: The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes (2013) (1)
Effects of pertussis toxin and its binding subunit on IL-1 signalling in T cells. (1995) (1)
IL-5/IL-13 drive NLRP3 inflammasome-mediated, steroid-resistant AHR in a model of obesity-associated asthma (2019) (1)
The effects of thiol modifiers on the activation of NF kappa B by interleukin-1. (1993) (1)
Crystal structure of the Toll / interleukin-1 receptor ( TIR ) domain of human IL-1 RAPL (2004) (1)
4 – Cytokine Receptor Superfamilies (2001) (1)
A vaccine for colorectral cancer. (2001) (1)
IGF I and II (2001) (1)
Regulation of miR-155 by Ets 2 1 The role of Ets 2 transcription factor in the induction of microRNA-155 by LPS , and its targeting by IL-10 (2013) (1)
Nrf2 is a central regulator of the metabolic landscape in macrophages and finetunes their inflammatory response (2021) (1)
Trained immunity, tolerance, priming and differentiation: distinct immunological processes (2020) (1)
An Emerging Role for Type I Interferons as Critical Regulators of Blood Coagulation (2023) (1)
NLRP3, the inflammasome and COVID-19 infection. (2023) (1)
A roll-call of monocytic gene induction. (2001) (1)
Spurs in the hunt for new immunomodulatory drug targets. (2012) (0)
Brain Signaling Complex , Highly Expressed in TRIL , a Functional Component of the TLR 4 (2009) (0)
Autocrine NLPR3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-γ in CD4+ T cells (2016) (0)
Comprar Toll-Like Receptors · Methods and Protocols | McCoy, Claire E. | 9781934115725 | Springer (2009) (0)
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A call for cord blood (2001) (0)
TLRs, NLRs, DAMPs and PAMPs (2012) (0)
Toll-like receptors: methods and protocols.Preface. (2009) (0)
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DAUNORUBICIN ACTIVATES NFkB AND POTENTIATES TNF-INDUCED GENE EXPRESSION (1996) (0)
Modulation of the peripheral-type benzodiazepene acceptor by IL1 and PMA (1992) (0)
203: IL10 inhibits induction of miR-155 by suppressing Ets2 – A possible mechanism for the anti-inflammatory effects of IL10 (2013) (0)
A battle cry to decipher immunity (2004) (0)
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GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity (2017) (0)
IL1 and TLR Signal Transduction-Ancient Signalling Pathways Involved In Host Defence (2000) (0)
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SS4-1 New targets and processes in the control of TLRs and NLRP3 (2010) (0)
Hyaluronic Acid Fragments Activate NFκB in ECV304 Cells Via Its Principal Cell Surface Receptor CD44 (1999) (0)
TLR 3 TLR 2 Signaling and Inhibits Signaling by MyD 88 Adaptor-Like Is Not Essential for Golenbock (2009) (0)
TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-κB. (2010) (0)
Lysine Malonylation as a New Inflammatory Signal (2015) (0)
Toll-Like Receptors (2016) (0)
Control of the human Th1 response via autocrine complement-regulated NLRP3 inflammasome activation within CD4(+) T cells (2014) (0)
Building unique bonds to fight misplaced DNA (2013) (0)
Effect of pertussis toxin and PGE2 on the functioning of the IL-2 promoter in interleukin-1 treated EL4.NOB-1 thymoma cells. (1996) (0)
Lipopolysaccharide Helicobacter pylori TLR2-Mediated Signaling in Response to Tribbles 3: A Novel Regulator of (2011) (0)
Investigation into the role of protein kinase C in IL1 and PMA signalling in EL4.NOB-1 thymoma cells. (1996) (0)
Receptor-2 Antibody Receptor-2 and Reduced by Systemic Administration of a Novel Anti Toll-Like Myocardial Ischemia / Reperfusion Injury (2009) (0)
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Toll-like receptors: new therapeutic targets for autoimmune diseases (2002) (0)
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Extracts of feverfew inhibit mitogen-induced human peripheral blood mononuclear cell proliferation and cytokine mediated responses: A cytotoxic effect (1988) (0)
Virus Induced Signaling to Initiate the Interferon Mediated Anti-Viral Host Response (2005) (0)
High resolution crystal structure of murine IL-1F5 reveals unique loop conformation for specificity (2003) (0)
PBP, CTAP-III, NAP-2 and βTG (2001) (0)
Mal (MyD88 adapter-like) is a novel Toll IL-1 receptor (TIR) domain-containing adapter which recruits IRAK-2 during Toll-like receptor-4 signal transduction (2001) (0)
Depolarising levels of KCl inhibit endothelin-1-mediated release of arachidonic acid in rat C6 glioma cells. (1995) (0)
Antithrombin III and hirudin inhibits LPS-mediated NF-κB activation (2001) (0)
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Itaconate: the poster child of metabolic reprogramming in macrophage function (2019) (0)
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Protein targeting by the itaconate family in immunity and inflammation. (2022) (0)
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Anti-TNF yields a block-buster (2001) (0)
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Combined in Vivo and in Vitro Analyses Identify the Caspase-1/trpm2 Axis as a Contributor to Neutrophil-Driven Airway Inflammation in Cystic Fibrosis (2014) (0)
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Who needs adaptive immunity (2001) (0)
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Creating ATP via creatine kinase B for NLRP3 activation (2022) (0)
Rocking the world of innate immunity: an interview with Luke O'Neill (2018) (0)
Microsoft Word-Zhang et al., text fi (2009) (0)
An AIDS vaccine in sight? (2001) (0)
Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation (2017) (0)
Cytokine release inhibitor drug, CRID3, inhibits the NLRP3 inflammasome in glia (2014) (0)
Immunometabolism at the crossroads of obesity and cancer-a Keystone Symposia report. (2023) (0)
Malonylation of GAPDH is an inflammatory signal in macrophages (2019) (0)
The IL1 receptor homologue T1/ST2 activates MAP kinases and AP1 but not NF-kappaB (2001) (0)
Detailed analysis of the murine Irak-2 gene and its coding sequence reveals four alternatively spliced variants (2004) (0)
Toll-like receptor signalling during infection and inflammation (2010) (0)
Nuclear Factor (cid:1) B2 p52 Protein Has a Role in Antiviral Immunity through I (cid:1) B Kinase (cid:2) -dependent Induction of Sp1 Protein and Interleukin 15 * (2013) (0)
Evidence against a role for NLRP3-driven inflammation in the db/db mouse model of type 2 diabetes (2016) (0)
Tyrosine Phosphorylation of MAL in TLR4 Signaling and Endotoxin Tolerance (2008) (0)
High Fat Diet-Induced Obesity Promotes Steroid-Resistant Asthma Through An Nlrp3 Inflammasome-Dependent Mechanism (2017) (0)
Session 3: Signalling in inflammatory and immune cells: cell surface to nucleus (2004) (0)
Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming (2018) (0)
Activation of NFϰB by IL1 in C6 glioma cells (1992) (0)
Resisting resistance with PAF receptor antagonists (2002) (0)
Passive smoking increases allergy (2001) (0)
458: A novel role for free fetal DNA in non-infectious preterm birth (2011) (0)
The anti-inflammatory cytokine IL-10 inhibits miR-155 in response to Toll-like Receptor signalling (2009) (0)
Toll-like receptors : methods and protocols (2009) (0)
3000 genes are induced when dendritic cells encounter live bacteria (2001) (0)
PL1-3 IL-6 Trans-signaling modulates TLR4-dependent inflammatory responses via STAT3 (2010) (0)
Infection Escherichia coli the Brain following TRIL Is Involved in Cytokine Production in (2014) (0)
NLRP3 inflammasome-mediated, IL-1 beta-dependent inflammatory responses drive severe, steroid-insensitive asthma (2016) (0)
Induces k B-dependent Gene Expression in HL-60 Promyelocytic and Jurkat T Lymphoma Cells (1997) (0)
Recent developments in innate immune antiviral sensing and signaling (2011) (0)
179: MIRNA analysis reveals novel insights into IL10 function (2013) (0)
Warning: anti-TNF therapy might cause tuberculosis (2002) (0)
INFLAMMATION OVERVIEW AND MARKERS OF INFLAMMATION (2011) (0)
Glutaminolysis and Fumar ate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity Graphical (2016) (0)
223 Toll-Like Receptor 2-Dependent Chemokine Induction in Epithelial Cells By Lipopolysaccharide Contained in Helicobacter pylori Outer Membrane Vesicles (2009) (0)
コハク酸はHIF‐1αを介してIL‐1βを誘導する炎症性シグナルである (2013) (0)
Vaccine safety concerns. (2001) (0)
Innate Immunity and Inflammation How Metabolism Generates Signals during Minireviews : (2013) (0)

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