Lumír Krejčí
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Lumír Krejčícomputer-science Degrees
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Computer Science
Lumír Krejčí's Degrees
- PhD Computer Science Charles University
- Masters Computer Science Charles University
- Bachelors Computer Science Charles University
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Why Is Lumír Krejčí Influential?
(Suggest an Edit or Addition)According to Wikipedia, Lumír Krejčí is a Czech biochemist. His research is focused on regulatory processes involved in maintaining genome integrity. Currently, as Associate Professor in biochemistry, he leads the laboratory of recombination and DNA repair at the Department of Biology, Faculty of Medicine, at Masaryk University in Brno.
Lumír Krejčí's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- DNA helicase Srs2 disrupts the Rad51 presynaptic filament (2003) (609)
- Homologous recombination and its regulation (2012) (579)
- Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p. (2005) (525)
- Rad51 Recombinase and Recombination Mediators* (2003) (428)
- SAMHD1 acts at stalled replication forks to prevent interferon induction (2018) (250)
- Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination. (2009) (243)
- Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments (2017) (242)
- Biochemical characterization of the RECQ4 protein, mutated in Rothmund-Thomson syndrome. (2006) (144)
- Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA. (2009) (142)
- Recombination Mediator and Rad51 Targeting Activities of a Human BRCA2 Polypeptide* (2006) (132)
- Interaction with Rad51 Is Indispensable for Recombination Mediator Function of Rad52* (2002) (125)
- Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination (2015) (117)
- RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops (2020) (88)
- Cdk1 Targets Srs2 to Complete Synthesis-Dependent Strand Annealing and to Promote Recombinational Repair (2010) (85)
- Saccharomyces cerevisiae MPH1 Gene, Required for Homologous Recombination-mediated Mutation Avoidance, Encodes a 3′ to 5′ DNA Helicase* (2005) (81)
- Srs2: The “Odd-Job Man” in DNA repair (2010) (78)
- Molecular Dissection of Interactions between Rad51 and Members of the Recombination-Repair Group (2001) (77)
- Localization of recombination proteins and Srs2 reveals anti-recombinase function in vivo (2009) (77)
- Role of ATP Hydrolysis in the Antirecombinase Function of Saccharomyces cerevisiae Srs2 Protein* (2004) (75)
- Role of PCNA and TLS polymerases in D-loop extension during homologous recombination in humans☆ (2013) (75)
- PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis (2017) (74)
- Interaction with RPA Is Necessary for Rad52 Repair Center Formation and for Its Mediator Activity* (2008) (74)
- Reconstitution of DNA repair synthesis in vitro and the role of polymerase and helicase activities (2011) (72)
- Rad52 SUMOylation affects the efficiency of the DNA repair (2010) (67)
- Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption (2009) (67)
- Cooperativity of Mus81·Mms4 with Rad54 in the Resolution of Recombination and Replication Intermediates*S⃞ (2009) (67)
- RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis. (2017) (67)
- Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis (2013) (63)
- Mending the break: two DNA double-strand break repair machines in eukaryotes. (2003) (63)
- Dual roles of the SUMO-interacting motif in the regulation of Srs2 sumoylation (2012) (59)
- Effect of Amino Acid Substitutions in the Rad50 ATP Binding Domain on DNA Double Strand Break Repair in Yeast* (2005) (58)
- Molecular Anatomy of the Recombination Mediator Function of Saccharomyces cerevisiae Rad52* (2008) (58)
- Strand invasion by HLTF as a mechanism for template switch in fork rescue (2013) (56)
- Local regulation of the Srs2 helicase by the SUMO-like domain protein Esc2 promotes recombination at sites of stalled replication (2015) (55)
- ATPase and DNA Helicase Activities of the Saccharomyces cerevisiae Anti-recombinase Srs2* (2003) (54)
- DNA helicase Srs 2 disrupts the Rad 51 presynaptic filament (2003) (53)
- Fanconi-Anemia-Associated Mutations Destabilize RAD51 Filaments and Impair Replication Fork Protection. (2017) (53)
- CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes (2019) (52)
- Regulation of Rad51 Recombinase Presynaptic Filament Assembly via Interactions with the Rad52 Mediator and the Srs2 Anti-recombinase* (2009) (51)
- Genetic analysis of the Saccharomyces cerevisiae Sgs1 helicase defines an essential function for the Sgs1-Top3 complex in the absence of SRS2 or TOP1 (2000) (44)
- Sumoylation regulates EXO1 stability and processing of DNA damage (2015) (42)
- SAMHD1 acts at stalled replication forks to prevent interferon induction (2018) (40)
- Unwinding of synthetic replication and recombination substrates by Srs2 (2012) (37)
- A Polar and Nucleotide-Dependent Mechanism of Action for RAD51 Paralogs in RAD51 Filament Remodeling (2016) (35)
- The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis (2016) (34)
- A structure–function analysis of the yeast Elg1 protein reveals the importance of PCNA unloading in genome stability maintenance (2017) (32)
- DNA, the central molecule of aging. (2016) (32)
- Sumoylation Influences DNA Break Repair Partly by Increasing the Solubility of a Conserved End Resection Protein (2015) (30)
- Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance (2016) (28)
- Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells (2015) (28)
- Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA association (2014) (26)
- Esc2 promotes Mus81 complex-activity via its SUMO-like and DNA binding domains (2016) (23)
- Cancer TARGETases: DSB repair as a pharmacological target. (2016) (23)
- Human RAD51 rapidly forms intrinsically dynamic nucleoprotein filaments modulated by nucleotide binding state (2018) (23)
- Rad52 SUMOylation affects the efficiency of the DNA repair (2012) (23)
- Srs2 promotes Mus81–Mms4-mediated resolution of recombination intermediates (2015) (21)
- Smarcal 1-Mediated Fork R eversal Triggers Mre 11-Dependent Degradation of Nascent DNA in the Absence of Brca 2 and Stable Rad 51 Nucleofilaments Graphical (20)
- Impaired mitophagy in Fanconi anemia is dependent on mitochondrial fission (2016) (20)
- Unloading of homologous recombination factors is required for restoring double‐stranded DNA at damage repair loci (2017) (20)
- Nucleases in homologous recombination as targets for cancer therapy (2014) (19)
- DSS1 interacts with and stimulates RAD52 to promote the repair of DSBs (2019) (19)
- A Versatile Scaffold Contributes to Damage Survival via Sumoylation and Nuclease Interactions (2014) (19)
- Pro-recombination Role of Srs2 Protein Requires SUMO (Small Ubiquitin-like Modifier) but Is Independent of PCNA (Proliferating Cell Nuclear Antigen) Interaction* (2016) (18)
- Deficiency and haploinsufficiency of histone macroH2A1.1 in mice recapitulate hematopoietic defects of human myelodysplastic syndrome (2019) (14)
- Mechanism of Homologous Recombination (2016) (13)
- Role of PCNA and RFC in promoting Mus81-complex activity (2017) (13)
- RECQ4 selectively recognizes Holliday junctions. (2015) (13)
- Lif1 SUMOylation and its role in non-homologous end-joining (2013) (13)
- The PCNA Interaction Protein Box Sequence in Rad54 Is an Integral Part of Its ATPase Domain and Is Required for Efficient DNA Repair and Recombination (2013) (11)
- Mitochondrial dysfunction in DDR-related cancer predisposition syndromes. (2016) (11)
- The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel‐resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe (2020) (10)
- Yeast mitochondrial HMG proteins: DNA-binding properties of the most evolutionarily divergent component of mitochondrial nucleoids (2015) (9)
- Antibiotic-induced DNA damage results in a controlled loss of pH homeostasis and genome instability (2020) (9)
- SUMO Wrestles with Recombination (2012) (9)
- Targeted deletions created in yeast vectors by recombinational excision. (1999) (9)
- SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination. (2016) (9)
- RPA not that different from SSB. (2002) (9)
- Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates (2020) (9)
- Cooperativity of Mus81 (cid:1) Mms4 with Rad54 in the Resolution of Recombination and Replication Intermediates * □ (2020) (8)
- MEK and TGF-beta Inhibition Promotes Reprogramming without the Use of Transcription Factor (2015) (8)
- The structure and DNA-binding properties of Mgm101 from a yeast with a linear mitochondrial genome (2016) (7)
- Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation (2017) (7)
- Sumoylation regulates the stability and nuclease activity of Saccharomyces cerevisiae Dna2 (2019) (6)
- Sumoylation regulates the stability and nuclease activity of Saccharomyces cerevisiae Dna2 (2019) (5)
- Homomeric interaction of the mouse Rad52 protein (2000) (4)
- Yeast strains used in the study. (2015) (4)
- TREX2 Exonuclease Causes Spontaneous Mutations and Stress-Induced Replication Fork Defects in Cells Expressing RAD51K133A (2020) (4)
- A residue of motif III positions the helicase domains of motor subunit HsdR in restriction-modification enzyme EcoR124I (2018) (4)
- Reprint of "DNA, the central molecule of aging". (2016) (3)
- Corrigendum to “Srs2: The ‘Odd-Job Man”’ [DNA Repair 9 (2010) 268–275] (2012) (2)
- DNA Binding and Strand Annealing Properties of the Human BRCA2DNA Binding Domain (2005) (1)
- PRDM9 forms a multiprotein complex tethering recombination hotspots to the chromosomal axis (2016) (1)
- Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function (2021) (1)
- Regulation of Rad51 recombinase presynaptic filament assembly via interactions with the Rad52 mediator and the Srs2 anti-recombinase. (2012) (1)
- RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops (2020) (1)
- Chromosome location, genomic organization of the porcine COL10A1 gene and model structure of the NC1 domain (2004) (1)
- Role of PCNA and RFC in promoting Mus81-complex activity (2017) (0)
- Of forks and ends. (2002) (0)
- Cdk1 targets Srs2 to complete synthesis-dependent strandannealing and to promote (2010) (0)
- Role of BRCA2 in homologous recombination with special aspectson Dss1 protein (2006) (0)
- New insight into mediator function of yeast Rad52 protein (2005) (0)
- Fanconi anemia: The role of FANCD2 protein (2007) (0)
- A Mutation in Rad54 that Affects PCNA Interaction Results in Decreased Homologous Recombination Events Following Double‐Strand Breaks (2019) (0)
- Phosphorylation of Elg1 regulates its activity (2015) (0)
- Study of Rad52 SUMOylation (2008) (0)
- Rad52 Sumoylation Affects the Efficiency of the Recombinationand DNA Repair (2009) (0)
- EMBO DNA Repair Forum (2008) (0)
- DSB formation by Spo11 protein requires interaction with Mre11 (2016) (0)
- Role of Rad51-Mediated Interactions in Recombination (2004) (0)
- Biochemical Characterization of FAN1 Nuclease (2018) (0)
- Characterisation of two myb-like proteins showing affinity totelomeric DNA sequence from Arabidopsis thaliana (2003) (0)
- Molecular Dissection of Homologous Recombination (1999) (0)
- The role of bivalent ions in the regulation of D-loop extension mediated by DMC1 during meiotic recombination (2022) (0)
- Chronic lymphocytic leukemia cells are highly susceptible to direct inhibition of checkpoint kinase (2015) (0)
- Exploring synthetic lethal interaction between Checkpoint Kinase 1(CHK1) and DNA replication stress (2014) (0)
- Dissection of homologous recombination (1999) (0)
- DNA Repair Meeting 2008 (2008) (0)
- SURVEY AND SUMMARY Homologous recombination and its regulation (2012) (0)
- Role of BRCA2/FANCD1 in Homologous Recombination (2005) (0)
- Deficiency and haploinsufficiency of histone macroH2A1.1 in mice recapitulate hematopoietic defects of human myelodysplastic syndrome (2019) (0)
- Wrestling SUMO on proteins involved in homologous recombination (2008) (0)
- In Vitro Characterization of Sumoylation of HR Proteins. (2021) (0)
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