Lutz Birnbaumer

Q: What Schools Are Affiliated With Lutz Birnbaumer

Lutz Birnbaumer is affiliated with the following schools: Medical University of Graz, University of Cologne, University of Tokyo, University of California, Los Angeles, Stanford University, Baylor College of Medicine, Massachusetts General Hospital, Pontifical Catholic University of Argentina

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Lutz Birnbaumer

Biology

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#4788

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Molecular Biology

#203

World Rank

#207

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Neuroscience

#271

World Rank

#286

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Lutz Birnbaumer's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Receptor-effector coupling by G proteins. (1990) (952)
Nomenclature of Voltage-Gated Calcium Channels (2000) (895)
The TRP Channels, a Remarkably Functional Family (2002) (822)
trp, a Novel Mammalian Gene Family Essential for Agonist-Activated Capacitative Ca2+ Entry (1996) (686)
The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. V. An obligatory role of guanylnucleotides in glucagon action. (1971) (651)
Functional interaction between InsP3 receptors and store-operated Htrp3 channels (1998) (617)
Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channels. (2000) (606)
A unified nomenclature for the superfamily of TRP cation channels. (2002) (603)
The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. IV. Effects of guanylnucleotides on binding of 125I-glucagon. (1971) (524)
A G protein directly regulates mammalian cardiac calcium channels. (1987) (521)
Increased Vascular Smooth Muscle Contractility in TRPC6−/− Mice (2005) (488)
Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes. (1990) (461)
G proteins in signal transduction. (1990) (441)
Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel. (1992) (413)
Direct activation of mammalian atrial muscarinic potassium channels by GTP regulatory protein Gk. (1987) (395)
On the molecular basis and regulation of cellular capacitative calcium entry: roles for Trp proteins. (1996) (391)
Receptor-to-effector signaling through G proteins: Roles for βγ dimers as well as α subunits (1992) (390)
Ionic channels and their regulation by G protein subunits. (1990) (376)
The naming of voltage-gated calcium channels (1994) (371)
The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. I. Properties. (1971) (367)
The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. 3. Binding of glucagon: method of assay and specificity. (1971) (362)
TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination (2008) (361)
Modulation of Ca2+ entry by polypeptides of the inositol 1,4,5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): Evidence for roles of TRP and IP3R in store depletion-activated Ca2+ entry (1999) (353)
Evidence for dual coupling of the murine luteinizing hormone receptor to adenylyl cyclase and phosphoinositide breakdown and Ca2+ mobilization. Studies with the cloned murine luteinizing hormone receptor expressed in L cells. (1992) (346)
Molecular cloning of a widely expressed human homologue for the Drosophila trp gene (1995) (338)
Adenyl cyclase in fat cells. 1. Properties and the effects of adrenocorticotropin and fluoride. (1969) (336)
Cloning and Expression of a Novel Mammalian Homolog ofDrosophila Transient Receptor Potential (Trp) Involved in Calcium Entry Secondary to Activation of Receptors Coupled by the Gq Class of G Protein* (1997) (335)
Receptor-activated Ca2+ Influx via Human Trp3 Stably Expressed in Human Embryonic Kidney (HEK)293 Cells (1998) (333)
Orai proteins interact with TRPC channels and confer responsiveness to store depletion (2007) (320)
Trp2 regulates entry of Ca2+ into mouse sperm triggered by egg ZP3 (2001) (316)
Physiology and pathophysiology of canonical transient receptor potential channels (2009) (315)
Ulcerative colitis and adenocarcinoma of the colon in Gαi2-deficient mice (1995) (304)
Direct G protein gating of ion channels. (1988) (300)
A TRPC6-dependent pathway for myofibroblast transdifferentiation and wound healing in vivo. (2012) (291)
Identification of Common Binding Sites for Calmodulin and Inositol 1,4,5-Trisphosphate Receptors on the Carboxyl Termini of Trp Channels* (2001) (290)
Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart (2012) (288)
Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels (2008) (286)
The G protein-gated atrial K+ channel is stimulated by three distinct GIα-subunits (1988) (282)
Induction of calcium currents by the expression of the α1-subunit of the dihydropyridine receptor from skeletal muscle (1989) (282)
The alpha subunit of the GTP binding protein Gk opens atrial potassium channels. (1987) (279)
Adenyl cyclase in fat cells. II. Hormone receptors. (1969) (277)
Ca2+-induced inhibition of the cardiac Ca2+ channel depends on calmodulin. (1999) (277)
Normalization of current kinetics by interaction between the α1and β subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel (1991) (270)
Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel. (1999) (265)
Pressure-induced and store-operated cation influx in vascular smooth muscle cells is independent of TRPC1 (2007) (259)
Stimulation and inhibition of adenylyl cyclases mediated by distinct regulatory proteins (1983) (258)
Potentiation by the beta subunit of the ratio of the ionic current to the charge movement in the cardiac calcium channel. (1993) (256)
Direct interaction of Gβγ with a C-terminal Gβγ-binding domain of the Ca2+ channel α1 subunit is responsible for channel inhibition by G protein-coupled receptors (1997) (256)
Cloning and expression of a neuronal calcium channel beta subunit. (1993) (239)
Structures and Functions of Calcium Channel β Subunits (1998) (233)
The TRPC class of ion channels: a critical review of their roles in slow, sustained increases in intracellular Ca(2+) concentrations. (2009) (231)
The stimulatory G protein of adenylyl cyclase, Gs, also stimulates dihydropyridine-sensitive Ca2+ channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonist. (1988) (228)
Multiple neurological abnormalities in mice deficient in the G protein Go. (1998) (223)
A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry (2009) (221)
Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go. (1988) (218)
Adenylyl cyclase activities in ovarian tissues. I. Homogenization and conditions of assay in graafian follicles and corpora lutea of rabbits, rats, and pigs: regulation by ATP, and some comparative properties. (1976) (214)
Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(−/−) mice (2007) (213)
The amino terminus of a calcium channel β subunitsets rates of channel inactivation independently of the subunit's effect on activation (1994) (213)
Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain (2001) (210)
Serum antibodies to L-type calcium channels in patients with amyotrophic lateral sclerosis. (1992) (207)
Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes. (1990) (205)
TRPC1 Channels Are Critical for Hypertrophic Signaling in the Heart (2009) (202)
Dual signaling potential is common among Gs-coupled receptors and dependent on receptor density. (1994) (201)
Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response (2018) (200)
Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling. (2012) (200)
Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels. (1989) (199)
The Light Response of ON Bipolar Neurons Requires Gαo (2000) (198)
Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets. (2005) (195)
TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation (2012) (195)
Heterologous regulation of the cardiac Ca2+ channel alpha 1 subunit by skeletal muscle beta and gamma subunits. Implications for the structure of cardiac L-type Ca2+ channels. (1991) (195)
A Xenopus oocyte beta subunit: evidence for a role in the assembly/expression of voltage-gated calcium channels that is separate from its role as a regulatory subunit. (1997) (195)
Cloning and expression of a third calcium channel beta subunit. (1993) (194)
Hormone-stimulated desensitization of hormone-dependent adenylyl cyclase. Dual action of luteninizing hormone on pig graafian follicle membranes. (1976) (189)
The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system. (1984) (189)
Modification of Ca2+ channel activity by deletions at the carboxyl terminus of the cardiac alpha 1 subunit. (1994) (185)
ADP-ribosylation of membrane components by pertussis and cholera toxin. (1985) (183)
Hormone-sensitive adenylyl cyclases. Useful models for studying hormone receptor functions in cell-free systems. (1973) (182)
Unique regulatory properties of the type 2a Ca2+ channel beta subunit caused by palmitoylation. (1998) (180)
Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium. (1983) (175)
The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. VI. Evidence for a role of membrane lipids. (1971) (174)
Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry. (1999) (172)
The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. II. Comparison between glucagon- and fluoride-stimulated activities. (1971) (170)
Ns and Ni, the stimulatory and inhibitory regulatory components of adenylyl cyclases. Purification of the human erythrocyte proteins without the use of activating regulatory ligands. (1984) (169)
G(alpha)i2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines. (1997) (169)
Signaling Mechanism for Receptor-activated Canonical Transient Receptor Potential 3 (TRPC3) Channels* (2003) (166)
Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo. (2009) (166)
Reconstitution of somatostatin and muscarinic receptor mediated stimulation of K+ channels by isolated GK protein in clonal rat anterior pituitary cell membranes. (1987) (164)
TRPC6 Contributes to the Ca2+ Leak of Human Erythrocytes (2008) (163)
Molecular cloning and expression of a fifth muscarinic acetylcholine receptor. (1989) (160)
Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. (1995) (159)
Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. (1985) (158)
Signal transduction by G proteins. (1987) (154)
Expansion of signal transduction by G proteins. The second 15 years or so: from 3 to 16 alpha subunits plus betagamma dimers. (2007) (154)
Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles. (1986) (151)
Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy (2014) (150)
G protein Gαo is essential for vomeronasal function and aggressive behavior in mice (2011) (150)
Regulation of hormone receptors and adenylyl cyclases by guanine nucleotide binding N proteins. (1985) (148)
Quercetin alleviates acute kidney injury by inhibiting ferroptosis (2020) (146)
Cloning of Trp1β isoform from rat brain: immunodetection and localization of the endogenous Trp1 protein. (1999) (145)
Identification of a gamma subunit associated with the adenylyl cyclase regulatory proteins Ns and Ni. (1984) (142)
Deletion of TRPC3 in mice reduces store-operated Ca2+ influx and the severity of acute pancreatitis. (2009) (137)
The Membrane Topology of Human Transient Receptor Potential 3 as Inferred from Glycosylation-scanning Mutagenesis and Epitope Immunocytochemistry* (1998) (136)
Adenylyl cyclase activities in ovarian tissues. II. Regulation of responsiveness to LH, FSH, and PGE1 in the rabbit. (1976) (136)
Macrophages Induce the Inflammatory Response in the Pulmonary Arthus Reaction through Gαi2 Activation That Controls C5aR and Fc Receptor Cooperation1 (2005) (134)
Glucagon-Sensitive Adenyl Cylase in Plasma Membrane of Hepatic Parenchymal Cells (1969) (134)
Adenyl cyclase in fat cells. 3. Stimulation by secretin and the effects of trypsin on the receptors for lipolytic hormones. (1969) (133)
Polarized but Differential Localization and Recruitment of STIM1, Orai1 and TRPC Channels in Secretory Cells (2011) (132)
Most central nervous system D2 dopamine receptors are coupled to their effectors by Go (2001) (132)
TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells (2012) (130)
Innate Predator Odor Aversion Driven by Parallel Olfactory Subsystems that Converge in the Ventromedial Hypothalamus (2015) (129)
Adenylyl cyclase activities in ovarian tissues. III. Regulation of responsiveness to LH, FSH, and PGE1 in the prepubertal, cycling, pregnant, and pseudopregnant rat. (1976) (126)
The IVS6 segment of the L‐type calcium channel is critical for the action of dihydropyridines and phenylalkylamines. (1996) (125)
Antisera against a guanine nucleotide binding protein from retina cross-react with the beta subunit of the adenylyl cyclase-associated guanine nucleotide binding proteins, Ns and Ni. (1985) (124)
Light Response of Retinal ON Bipolar Cells Requires a Specific Splice Variant of Gαo (2002) (124)
Molecular cloning of a novel splice variant of the alpha subunit of the mammalian Go protein. (1990) (122)
Glucagon receptors in -cells. Binding of 125 I-glucagon and activation of adenylate cyclase. (1972) (117)
Effective gating charges per channel in voltage-dependent K+ and Ca2+ channels (1996) (117)
Hormone receptor modulates the regulatory component of adenylyl cyclase by reducing its requirement for Mg2+ and enhancing its extent of activation by guanine nucleotides. (1982) (116)
G protein subunits and the stimulation of phospholipase C by Gs-and Gi-coupled receptors: Lack of receptor selectivity of Galpha(16) and evidence for a synergic interaction between Gbeta gamma and the alpha subunit of a receptor activated G protein. (1996) (113)
Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton (2013) (113)
Canonical Transient Receptor Channel 5 (TRPC5) and TRPC1/4 Contribute to Seizure and Excitotoxicity by Distinct Cellular Mechanisms (2013) (112)
Effects of guanine nucleotides and Mg on human erythrocyte Ni and Ns, the regulatory components of adenylyl cyclase. (1984) (112)
Heteromeric TRPV4-C1 channels contribute to store-operated Ca(2+) entry in vascular endothelial cells. (2011) (112)
Guanine nucleotide inhibition of cyc- S49 mouse lymphoma cell membrane adenylyl cyclase. (1982) (112)
Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices. (2006) (111)
Modulation of coronary smooth muscle KCa channels by Gs alpha independent of phosphorylation by protein kinase A. (1993) (111)
Differential expression of the beta-adrenergic receptor modifies agonist stimulation of adenylyl cyclase: a quantitative evaluation. (1994) (109)
Guanine nucleotide regulation of a mammalian myocardial muscarinic receptor system. Evidence for homo- and heterotropic cooperativity in ligand binding analyzed by computer-assisted curve fitting. (1985) (108)
The light response of ON bipolar neurons requires G[alpha]o. (2000) (107)
G-protein distribution in canine cardiac sarcoplasmic reticulum and sarcolemma: comparison to rabbit skeletal muscle membranes and to brain and erythrocyte G-proteins. (1987) (107)
Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake (2013) (106)
Heart rate regulation by G proteins acting on the cardiac pacemaker channel. (1990) (106)
Genetic and pharmacologic inhibition of the Ca2+ influx channel TRPC3 protects secretory epithelia from Ca2+-dependent toxicity. (2011) (106)
The reaction of glucagon with its receptor: evidence for discrete regions of activity and binding in the glucagon molecule. (1971) (106)
Appearance of a novel Ca2+ influx pathway in Sf9 insect cells following expression of the transient receptor potential-like (trpl) protein of Drosophila. (1994) (105)
Removal of Giα1 Constraints on Adenylyl Cyclase in the Hippocampus Enhances LTP and Impairs Memory Formation (2004) (105)
Ionic currents underlying HTRP3 mediated agonist‐dependent Ca2+ influx in stably transfected HEK293 cells (1998) (105)
Role of TRPC1 channel in skeletal muscle function. (2010) (103)
Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit. (1984) (102)
Transduction of receptor signal into modulation of effector activity by G proteins: the first 20 years or so … (1990) (101)
Signal transduction by G proteins: 1994 edition. (1995) (100)
Studies on receptor-mediated activation of adenylyl cyclases. IV. Characteristics of the adrenergic receptor coupled to myocardial adenylyl cyclase: stereospecificity for ligands and determination of apparent affinity constants for beta-blockers. (1974) (99)
Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter (2013) (99)
Relation of glucagon-specific binding sites to glucagon-dependent stimulation of adenylyl cyclase activity in plasma membranes of rat liver. (1973) (96)
Efficacy of beta 1-adrenergic receptors is lower than that of beta 2-adrenergic receptors. (1993) (96)
Feedback inhibition of Ca2+ channels by Ca2+ depends on a short sequence of the C terminus that does not include the Ca2+ -binding function of a motif with similarity to Ca2+ -binding domains. (1997) (96)
An obligatory requirement for the heterotrimeric G protein Gi3 in the antiautophagic action of insulin in the liver (2007) (96)
Ca(2+)-dependent inactivation of a cloned cardiac Ca2+ channel alpha 1 subunit (alpha 1C) expressed in Xenopus oocytes. (1994) (95)
TRPV4, TRPC1, and TRPP2 assemble to form a flow‐sensitive heteromeric channel (2014) (95)
Factors affecting the activity of muscle glycogen synthetase. 3. The reaction with adenosine triphosphate Mg++, and cyclic 3'5'-adenosine monophosphate. (1966) (94)
β‐Subunits of the human liver Gs/Gi signal‐transducing proteins and those of bovine retinal rod cell transducin are identical (1986) (94)
Evidence for a physiological role of gonadotropin-releasing hormone (GnRH) or GnRH-like material in the ovary. (1985) (94)
The glucagon-sensitive adenylate cyclase system in plasma membranes of rat liver. VII. Hormonal stimulation: reversibility and dependence on concentration of free hormone. (1972) (93)
The membrane-bound spermatozoal adenylyl cyclase system does not share coupling characteristics with somatic cell adenylyl cyclases. (1985) (89)
Gamma-subunits of G proteins, but not their alpha- or beta-subunits, are polyisoprenylated. Studies on post-translational modifications using in vitro translation with rabbit reticulocyte lysates. (1991) (87)
Gαi1 and Gαi3 Are Required for Epidermal Growth Factor–Mediated Activation of the Akt-mTORC1 Pathway (2009) (86)
Role of Src in C3 transient receptor potential channel function and evidence for a heterogeneous makeup of receptor- and store-operated Ca2+ entry channels. (2006) (85)
Receptor-to-effector signaling through G proteins: roles for beta gamma dimers as well as alpha subunits. (1992) (85)
Inactivation of glucagon by plasma membranes of rat liver. (1972) (85)
A role for Ni in the hormonal stimulation of adenylate cyclase (1985) (84)
Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G protein of receptor-regulated K+ channels. (1988) (84)
A background Ca2+ entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling. (2015) (84)
TRPC6 is the endothelial calcium channel that regulates leukocyte transendothelial migration during the inflammatory response (2015) (84)
Angiotensin II has acute effects on TRPC6 channels in podocytes of freshly isolated glomeruli (2014) (83)
G alpha i-3 regulates epithelial Na+ channels by activation of phospholipase A2 and lipoxygenase pathways. (1990) (82)
Ca2+ mobilization by the LH receptor expressed in Xenopus oocytes independent of 3',5'-cyclic adenosine monophosphate formation: evidence for parallel activation of two signaling pathways. (1992) (82)
Mechanism of capacitative Ca2+ entry (CCE): interaction between IP3 receptor and TRP links the internal calcium storage compartment to plasma membrane CCE channels. (2000) (82)
Elucidation of a TRPC6-TRPC5 channel cascade that restricts endothelial cell movement. (2008) (82)
Hyperactive Adverse Mechanical Stress Responses in Dystrophic Heart Are Coupled to Transient Receptor Potential Canonical 6 and Blocked by cGMP–Protein Kinase G Modulation (2014) (81)
Structures and functions of calcium channel beta subunits. (1998) (80)
Characterization by two-dimensional peptide mapping of the gamma subunits of Ns and Ni, the regulatory proteins of adenylyl cyclase, and of transducin, the guanine nucleotide-binding protein of rod outer segments of the eye. (1985) (80)
A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease. (2018) (79)
Involvement of pertussis toxin-sensitive G-proteins in the hormonal inhibition of dihydropyridine-sensitive Ca2+ currents in an insulin-secreting cell line (RINm5F). (1991) (79)
A monoclonal antibody to the alpha subunit of Gk blocks muscarinic activation of atrial K+ channels. (1988) (78)
Reactive Oxygen Species-mediated TRPC6 Protein Activation in Vascular Myocytes, a Mechanism for Vasoconstrictor-regulated Vascular Tone* (2011) (78)
Melanopsin Phototransduction Is Repurposed by ipRGC Subtypes to Shape the Function of Distinct Visual Circuits (2018) (78)
Adenylyl cyclase activities in ovarian tissues. IV. Gonadotrophin-induced desensitization of the luteal adenylyl cyclase throughout pregnancy and pseudopregnancy in the rabbit and the rat. (1976) (77)
Distinct guanine nucleotide binding and release properties of the three Gi proteins. (1990) (76)
Potential Impacts of CO 2 Injection on Deep-Sea Biota (2001) (76)
GTP hydrolysis by pure Ni, the inhibitory regulatory component of adenylyl cyclases. (1984) (76)
Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho. (2017) (76)
Modulation of human neuronal α1E-type calcium channel by α2δ-subunit. (1998) (75)
Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2 (2010) (75)
Heteromeric Canonical Transient Receptor Potential 1 and 4 Channels Play a Critical Role in Epileptiform Burst Firing and Seizure-Induced Neurodegeneration (2012) (74)
Identification by molecular cloning of two forms of the α‐subunit of the human liver stimulatory (Gs) regulatory component of adenylyl cyclase (1986) (74)
Roles of G proteins in coupling of receptors to ionic channels and other effector systems. (1990) (74)
Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. (2009) (73)
Transient Receptor Potential Channels Function as a Coincidence Signal Detector Mediating Phosphatidylserine Exposure (2013) (73)
B cell developmental requirement for the G alpha i2 gene. (2003) (72)
Identification of a second region of the beta-subunit involved in regulation of calcium channel inactivation. (1996) (72)
Alpha-subunit of Gs directly activates cardiac calcium channels in lipid bilayers. (1988) (72)
TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling (2016) (70)
Transient receptor potential canonical type 3 channels facilitate endothelium-derived hyperpolarization-mediated resistance artery vasodilator activity. (2012) (70)
Classical Transient Receptor Potential 1 and 6 Contribute to Hypoxic Pulmonary Hypertension Through Differential Regulation of Pulmonary Vascular Functions (2014) (70)
Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype. (1992) (69)
The human genome encodes at least three non‐allellic G proteins with αi‐type subunits (1987) (69)
Adenylyl cyclase inhibition and altered G protein subunit expression and ADP-ribosylation patterns in tissues and cells from Gi2 alpha-/-mice. (1996) (69)
A comparison of the genes coding for canonical TRP channels and their M, V and P relatives. (2003) (68)
Cardioprotection specific for the G protein Gi2 in chronic adrenergic signaling through β2-adrenoceptors (2003) (67)
Aspartic Acid 564 in the Third Cytoplasmic Loop of the Luteinizing Hormone/Choriogonadotropin Receptor Is Crucial for Phosphorylation-independent Interaction with Arrestin2* (2002) (67)
Gαi2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation (2007) (65)
Regulation of hormone-receptor coupling to adenylyl cyclase. Effects of GTP and GDP. (1980) (63)
Noninvasive quantification of bowel inflammation through positron emission tomography imaging of 2-deoxy-2-[18F]fluoro-D-glucose-labeled white blood cells. (2003) (63)
Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling (2017) (63)
Go2 G protein mediates galanin inhibitory effects on insulin release from pancreatic β cells (2012) (62)
Erythropoietin Modulates Calcium Influx through TRPC2* (2002) (62)
Transient and steady state kinetics of the interaction of guanyl nucleotides with the adenylyl cyclase system from rat liver plasma membranes. Interpretation in terms of a simple two-state model. (1980) (61)
Molecular Determinants of Cardiac Ca2+ Channel Pharmacology (1995) (61)
Inhibition of L-Type Ca2+ Channels by TRPC1-STIM1 Complex Is Essential for the Protection of Dopaminergic Neurons (2017) (61)
Trp1‐dependent enhancement of salivary gland fluid secretion: role of store‐operated calcium entry (2001) (61)
Intrinsic phototransduction persists in melanopsin‐expressing ganglion cells lacking diacylglycerol‐sensitive TRPC subunits (2011) (60)
Studies on nucleotide and receptor regulation of Gi proteins: effects of pertussis toxin. (1989) (60)
Recombinant alpha i-3 subunit of G protein activates Gk-gated K+ channels. (1989) (60)
Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase (1992) (59)
Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries (2017) (59)
Normalization of current kinetics by interaction between the alpha 1 and beta subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel. (1991) (59)
Which G protein subunits are the active mediators in signal transduction (1987) (59)
TRPC6 channel translocation into phagosomal membrane augments phagosomal function (2015) (58)
Allergic pulmonary inflammation promotes the recruitment of circulating tumor cells to the lung. (2008) (58)
Trpc1 Ion Channel Modulates Phosphatidylinositol 3-Kinase/Akt Pathway during Myoblast Differentiation and Muscle Regeneration* (2012) (58)
Crystal Structure of Calmodulin Binding Domain of Orai1 in Complex with Ca2+•Calmodulin Displays a Unique Binding Mode* (2012) (58)
NMDA Receptor-Dependent Synaptic Activation of TRPC Channels in Olfactory Bulb Granule Cells (2012) (57)
Functional differences in the beta gamma complexes of transducin and the inhibitory guanine nucleotide regulatory protein. (1987) (57)
Calcium Channels Formed by Mammalian Trp Homologues. (1998) (57)
A TRPC1 Protein-dependent Pathway Regulates Osteoclast Formation and Function* (2013) (56)
TCR‐mediated hyper‐responsiveness of autoimmune Gαi2‐/‐ mice is an intrinsic naïve CD4+ T cell disorder selective for the Gαi2 subunit (2003) (56)
Coupling between charge movement and pore opening in vertebrate neuronal alpha 1E calcium channels. (1996) (55)
The discovery of signal transduction by G proteins: a personal account and an overview of the initial findings and contributions that led to our present understanding. (2007) (55)
The mouse C-type transient receptor potential 2 (TRPC2) channel: Alternative splicing and calmodulin binding to its N terminus (2003) (53)
Guanyl nucleotide regulation of hormonally-responsive adenylyl cyclases (1979) (53)
Guanine nucleotide and magnesium ion regulation of the interaction of gonadotropic and beta-adrenergic receptors with their hormones: a comparative study using a single membrane system. (1982) (53)
Hysteretic activation of adenylyl cyclases. I. Effect of Mg ion on the rate of activation by guanine nucleotides and fluoride. (1981) (52)
Evidence of a Role for Fibroblast Transient Receptor Potential Canonical 3 Ca2+ Channel in Renal Fibrosis. (2015) (52)
Oocyte adenylyl cyclase contains Ni, yet the guanine nucleotide‐dependent inhibition by progesterone is not sensitive to pertussis toxin (1984) (52)
XLαs, the extra-long form of the α-subunit of the Gs G protein, is significantly longer than suspected, and so is its companion Alex (2004) (52)
Inhibition of Gαi2 Activation by Gαi3 in CXCR3-mediated Signaling* (2007) (52)
Inhibitory regulation of adenylyl cyclase in the absence of stimulatory regulation. Requirements and kinetics of guanine nucleotide-induced inhibition of the cyc- S49 adenylyl cyclase. (1983) (52)
Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system. (1986) (52)
Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens (2018) (51)
A cardiac pathway of cyclic GMP-independent signaling of guanylyl cyclase A, the receptor for atrial natriuretic peptide (2011) (51)
TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis (2016) (51)
GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2. (2019) (50)
Gi2α protein deficiency: A model for inflammatory bowel disease (1995) (50)
TRPC1 proteins confer PKC and phosphoinositol activation on native heteromeric TRPC1/C5 channels in vascular smooth muscle: comparative study of wild‐type and TRPC1−/− mice (2012) (49)
Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric Galpha(i) proteins. (2005) (49)
Hormone receptor-mediated stimulation of adenylyl cyclase systems. Nucleotide effects and analysis in terms of a simple two-state model for the basic receptor-affected enzyme. (1980) (49)
Studies on receptor-mediated activation of adenylyl cyclases. III. Regulation by purine nucleotides of the activation of adenylyl cyclases from target organs for prostaglandins, luteinizing hormone, neurohypophyseal hormones and catecholamines. Tissue- and hormone-dependent variations. (1974) (49)
Studies on receptor-mediated activation of adenylyl cyclases. II. Nucleotide and nucleoside regulation of the activities of the beef renal medullary adenylyl cyclase and their stimulation by neurohypophyseal hormones. (1974) (48)
Divalent cation-induced desensitization of glucagon-stimulable adenylyl cyclase in rat liver plasma membrane. GTP-dependent stimulation by glucagon. (1980) (48)
Glucagon-stimulable adenylyl cyclase in rat liver. The impact of streptozotocin-induced diabetes mellitus. (1984) (48)
Adenosine diphosphate ribosylation of G proteins by pertussis and cholera toxin in isolated membranes. Different requirements for and effects of guanine nucleotides and Mg2+. (1987) (48)
Regression of Peyer's patches in Gαi2 deficient mice prior to colitis is associated with reduced expression of Bcl-2 and increased apoptosis (2002) (47)
Receptor-activated Ca Influx via Human Trp3 Stably Expressed in Human Embryonic Kidney (HEK)293 Cells (1997) (47)
Metabolism Regulates the Spontaneous Firing of Substantia Nigra Pars Reticulata Neurons via KATP and Nonselective Cation Channels (2014) (47)
A wide range of pheromone-stimulated sexual and reproductive behaviors in female mice depend on G protein Gαo (2014) (47)
TRPC3 channels critically regulate hippocampal excitability and contextual fear memory (2015) (47)
Coupling of the expressed alpha 1B-adrenergic receptor to the phospholipase C pathway in Xenopus oocytes. The role of Go. (1993) (46)
TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility. (2019) (46)
Mouse gene knockout and knockin strategies in application to alpha subunits of Gi/Go family of G proteins. (2002) (46)
Molecular cloning and sequence determination of a cDNA coding for the α‐subunit of a Go‐type protein of Xenopus laevis oocytes (1989) (46)
Increase in Ca2+ channel expression by deletions at the amino terminus of the cardiac alpha 1C subunit. (1996) (46)
TRPC2: molecular biology and functional importance. (2007) (46)
Receptor-specific desensitization of the S49 lymphoma cell adenylyl cyclase. Unaltered behavior of the regulatory component. (1981) (45)
Dual activation of the cardiac Ca2+ channel alpha 1C-subunit and its modulation by the beta-subunit. (1995) (45)
Heart β-Adrenoceptors (1978) (44)
The actions of insulin and catabolic hormones on the plasma membrane of the fat cells. (1968) (44)
Regulation of glucagon receptor binding. Lack of effect of Mg and preferential role for GDP. (1985) (44)
Cloning of a novel alpha 1-subunit of the voltage-dependent calcium channel from the beta-cell. (1992) (44)
Interaction of the stimulatory and inhibitory regulatory proteins of the adenylyl cyclase system with the catalytic component of cyc-S49 cell membranes. (1984) (44)
Hormonal regulation of pituitary GH3 cell K+ channels by Gk is mediated by its α‐subunit (1987) (44)
On the assay of adenyl cyclase. (1970) (44)
PLAGL2‐EGFR‐HIF‐1/2α Signaling Loop Promotes HCC Progression and Erlotinib Insensitivity (2020) (43)
Receptors and acceptors: a necessary distinction in hormone binding studies. (1974) (43)
A luteinizing hormone receptor with a severely truncated cytoplasmic tail (LHR-ct628) desensitizes to the same degree as the full-length receptor. (1993) (43)
Store‐operated channels regulate intracellular calcium in mammalian rods (2012) (42)
G proteins and the mechanism of action of hormones, neurotransmitters, and autocrine and paracrine regulatory factors. (1990) (42)
The TRPC family of TRP channels: roles inferred (mostly) from knockout mice and relationship to ORAI proteins. (2014) (42)
Mechanism of Stretch-Induced Activation of the Mechanotransducer Zyxin in Vascular Cells (2012) (42)
Prostaglandin E1 action on sinus pacemaker and adenylyl cyclase in kitten myocardium (1974) (42)
Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1. (2010) (41)
Antidepression action of BDNF requires and is mimicked by Gαi1/3 expression in the hippocampus (2018) (41)
Cellular responses to stimulation of the M5 muscarinic acetylcholine receptor as seen in murine L cells. (1990) (40)
Identification, characterization and subcellular localization of TcPDE1, a novel cAMP-specific phosphodiesterase from Trypanosoma cruzi. (2004) (40)
The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing (2016) (40)
Beta gamma dimers of G proteins inhibit atrial muscarinic K+ channels. (1990) (40)
Mechanisms in the vectorial receptor-adenylate cyclase signal transduction. (1984) (39)
Requirement for intramolecular domain interaction in activation of G protein alpha subunit by aluminum fluoride and GDP but not by GTP gamma S. (1994) (39)
At least three alternatively spliced mRNAs encoding two alpha subunits of the Go GTP-binding protein can be expressed in a single tissue. (1990) (39)
Studies on receptor-mediated activation of adenylyl cyclases. I. Preparation and description of general properties of an adenylyl cyclase system in beef renal medullary membranes sensitive to neurohypophyseal hormones. (1974) (39)
Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel. (2005) (39)
Studies on the structural requirements for the activity of the skeletal muscle dihydropyridine receptor/slow Ca2+ channel. Allosteric regulation of dihydropyridine binding in the absence of alpha 2 and beta components of the purified protein complex. (1990) (38)
Gi2 alpha protein deficiency: a model of inflammatory bowel disease. (1995) (38)
Impairment of survival signaling and efferocytosis in TRPC3-deficient macrophages. (2011) (38)
Gαo2 Regulates Vesicular Glutamate Transporter Activity by Changing Its Chloride Dependence (2005) (38)
Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors. (1997) (37)
Activation of Endothelial Transient Receptor Potential C3 Channel Is Required for Small Conductance Calcium‐Activated Potassium Channel Activation and Sustained Endothelial Hyperpolarization and Vasodilation of Cerebral Artery (2014) (37)
Forskolin regulation of liver membrane adenylyl cyclase. (1983) (37)
Membrane translocation of TRPC6 channels and endothelial migration are regulated by calmodulin and PI3 kinase activation (2016) (37)
Human chorionic gonadotropin-induced heterologous desensitization of adenylyl cyclase from highly luteinized rat ovaries: attenuation of regulatory N component activity. (1983) (37)
Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway (2018) (37)
Gαi2 Signaling Is Required for Skeletal Muscle Growth, Regeneration, and Satellite Cell Proliferation and Differentiation (2013) (37)
Central role of G protein Gαi2 and Gαi2+ vomeronasal neurons in balancing territorial and infant-directed aggression of male mice (2019) (36)
The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics. (2008) (36)
M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry (2018) (36)
XLalphas, the extra-long form of the alpha-subunit of the Gs G protein, is significantly longer than suspected, and so is its companion Alex. (2004) (36)
Bone marrow deficiency of TRPC3 channel reduces early lesion burden and necrotic core of advanced plaques in a mouse model of atherosclerosis. (2014) (36)
The RNA-Binding Protein, ZFP36L2, Influences Ovulation and Oocyte Maturation (2014) (36)
Store‐operated interactions between plasmalemmal STIM1 and TRPC1 proteins stimulate PLCβ1 to induce TRPC1 channel activation in vascular smooth muscle cells (2016) (36)
Differential regulation of lipopolysaccharide and Gram‐positive bacteria induced cytokine and chemokine production in macrophages by Gαi proteins (2007) (35)
Early Onset of Ataxia in Moonwalker Mice Is Accompanied by Complete Ablation of Type II Unipolar Brush Cells and Purkinje Cell Dysfunction (2013) (35)
TRPC3/6/7 Knockdown Protects the Brain from Cerebral Ischemia Injury via Astrocyte Apoptosis Inhibition and Effects on NF-кB Translocation (2017) (35)
The actions of hormones on the adenyl cyclase system. (1970) (35)
Properties of the hormonally responsive rabbit luteal adenylyl cyclase: effects of guanine nucleotides and magnesium ion on stimulation by gonadotropin and catecholamines. (1982) (35)
G protein opening of K+ channels (1987) (34)
TRPC1 regulates calcium‐activated chloride channels in salivary gland cells (2015) (34)
Coupling of glucagon receptor to adenylyl cyclase. Requirement of a receptor-related guanyl nucleotide binding site for coupling of receptor to the enzyme. (1979) (34)
The interaction of nucleotides with pertussis toxin. Direct evidence for a nucleotide binding site on the toxin regulating the rate of ADP-ribosylation of Ni, the inhibitory regulatory component of adenylyl cyclase. (1986) (34)
Transducin and the inhibitory nucleotide regulatory protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid vesicle systems. (1985) (33)
Membrane-delimited stimulation of heart cell calcium current by beta-adrenergic signal-transducing Gs protein. (1990) (33)
Inhibition of TRPC1-Dependent Store-Operated Calcium Entry Improves Synaptic Stability and Motor Performance in a Mouse Model of Huntington's Disease. (2018) (33)
Reinvigorating exhausted CD8+ cytotoxic T lymphocytes in the tumor microenvironment and current strategies in cancer immunotherapy (2020) (33)
Developmental changes in the hormonal regulation of rat testis Sertoli cell adenylyl cyclase. (1981) (33)
Facilitation by the β2a subunit of pore openings in cardiac Ca2+ channels (1998) (33)
Ovarian responses of pregnant mare serum gonadotropin- and human chorionic gondotropin-primed rats: desensitizing, luteolytic, and ovulatory effects of a single dose of human chorionic gonadotropin. (1979) (33)
Reticulocyte lysates synthesize an active alpha subunit of the stimulatory G protein Gs. (1988) (32)
Molecular diversity and function of G proteins and calcium channels. (1991) (32)
Expanded methyl-sensitive cut counting reveals hypomethylation as an epigenetic state that highlights functional sequences of the genome (2011) (32)
Involvement of OA1, an intracellular GPCR, and G alpha i3, its binding protein, in melanosomal biogenesis and optic pathway formation. (2008) (32)
Serotonergic and adrenergic regulation of skeletal muscle metabolism in the rat. II. The use of [125I]iodolysergic acid diethylamide and [125I]iodopindolol as probes of sarcolemmal receptor function and specificity. (1983) (32)
Platelet Gi protein Gαi2 is an essential mediator of thrombo-inflammatory organ damage in mice (2015) (32)
Critical role of canonical transient receptor potential channel 7 in initiation of seizures (2014) (32)
Lack of muscarinic regulation of Ca2+ channels in Gi2α gene knockout mouse hearts (2001) (32)
Peptide inhibitors of ADP-ribosylation by pertussis toxin are substrates with affinities comparable to those of the trimeric GTP-binding proteins. (1992) (31)
Characterization of zfs1 as an mRNA-binding and -destabilizing Protein in Schizosaccharomyces pombe* (2008) (31)
Guanosine 5'-O-(3-thiotriphosphate) reduces ADP-ribosylation of the inhibitory guanine nucleotide-binding regulatory protein of adenylyl cyclase (Ni) by pertussis toxin without causing dissociation of the subunits of Ni. Evidence of existence of heterotrimeric pt+ and pt- conformations of Ni. (1987) (31)
Gαo Represses Insulin Secretion by Reducing Vesicular Docking in Pancreatic β-Cells (2010) (31)
Resensitization of the desensitized follicular adenylyl cyclase system to luteinizing hormone. (1979) (31)
Inhibitory Regulation of Adenylyl Cyclases. Evidence Inconsistent with βγ-Complexes of Gi Proteins Mediating Hormonal Effects by Interfering with Activation of Gs (1987) (31)
Mechanism of action of somatostatin. (1988) (31)
Expansion of signal transduction by G proteins The second 15 years or so: From 3 to 16 α subunits plus βγ dimers (2007) (31)
Improved methods for determination of guanylyl cyclase activity and synthesis of [α-32P]GTP (1979) (31)
Transient receptor potential channel 6 knockdown prevents apoptosis of renal tubular epithelial cells upon oxidative stress via autophagy activation (2018) (30)
Development of the mammalian axial skeleton requires signaling through the Gαi subfamily of heterotrimeric G proteins (2012) (30)
Gαi1 and Gαi3 regulate macrophage polarization by forming a complex containing CD14 and Gab1 (2015) (30)
Adenyl Cyclase in Fat Cells THE EFFECTS OF ADRENOCORTICOTROPIN AND FLUORIDE (2002) (29)
Monoiodoglucagon: synthesis, purification by high pressure liquid chromatography, and characteristics as a receptor probe. (1983) (29)
TCR-mediated hyper-responsiveness of autoimmune Galphai2(-/-) mice is an intrinsic naïve CD4(+) T cell disorder selective for the Galphai2 subunit. (2003) (29)
Myristoylated alanine‐rich C kinase substrate coordinates native TRPC1 channel activation by phosphatidylinositol 4,5‐bisphosphate and protein kinase C in vascular smooth muscle (2014) (29)
Expression of the α2δ Subunit Interferes with Prepulse Facilitation in Cardiac L-type Calcium Channels (2000) (29)
Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders (2021) (29)
Blunted apoptosis of erythrocytes in mice deficient in the heterotrimeric G-protein subunit Gαi2 (2016) (28)
B Cell Developmental Requirement for the Gαi2 Gene (2004) (28)
Evidence for constitutive bone morphogenetic protein-2 secretion by M1 macrophages: Constitutive auto/paracrine osteogenic signaling by BMP-2 in M1 macrophages. (2017) (28)
Alpha-subunit of Gk activates atrial K+ channels of chick, rat, and guinea pig. (1988) (27)
Coordinated control of sensitivity by two splice variants of Gαo in retinal ON bipolar cells (2010) (27)
FSH and LH/hCG responsive adenylyl cyclases in adult rat testes: methodology and assay conditions. (1980) (27)
Thymopentin ameliorates dextran sulfate sodium-induced colitis by triggering the production of IL-22 in both innate and adaptive lymphocytes (2019) (27)
Simultaneous deletion of floxed genes mediated by CaMKIIα-Cre in the brain and in male germ cells: application to conditional and conventional disruption of Goα (2014) (27)
Increased size and cellularity of advanced atherosclerotic lesions in mice with endothelial overexpression of the human TRPC3 channel (2015) (27)
Molecular basis of regulation of ionic channels by G proteins. (1989) (26)
Direct coupling of the somatostatin receptor to potassium channels by a G protein. (1990) (26)
Store depletion induces Gαq-mediated PLCβ1 activity to stimulate TRPC1 channels in vascular smooth muscle cells (2015) (26)
Insulin secretion stimulated by L-arginine and its metabolite L-ornithine depends on Gα(i2). (2014) (26)
Coupling of the glucagon receptor to adenylyl cyclase by GDP: evidence for two levels of regulation of adenylyl cyclase. (1979) (26)
Transient Receptor Potential Channel 1 Deficiency Impairs Host Defense and Proinflammatory Responses to Bacterial Infection by Regulating Protein Kinase Cα Signaling (2015) (26)
Modulation of cardiac CaV1.2 channels by dihydropyridine and phosphatase inhibitor requires Ser-1142 in the domain III pore loop (2003) (26)
Compartmentalization of protein kinase A signaling by the heterotrimeric G protein Go (2006) (26)
Incubation of bovine thyroid slices with thyrotropin is associated with a decrease in the ability of pertussis toxin to adenosine diphosphate-ribosylate guanine nucleotide regulatory component(s). (1987) (26)
The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go (2016) (25)
Transient Receptor Potential Canonical 3 (TRPC3) Channels Are Required for Hypothalamic Glucose Detection and Energy Homeostasis (2016) (25)
Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice. (2012) (25)
Iodohydroxybenzylpindolol: preparation, purification, localization of its iodine to the indole ring, and characterization as a partial agonist. (1980) (25)
Prostacyclin activation of adenylyl cyclase in rabbit corpus luteum membranes: comparison with 6-keto prostaglandin F1 alpha and prostaglandin E1. (1979) (25)
A truncated recombinant alpha subunit of Gi3 with a reduced affinity for beta gamma dimers and altered guanosine 5'-3-O-(thio)triphosphate binding. (1992) (25)
Identification of the G-protein α-subunit encoded by αo2 cDNA as a 39 kDa pertussis toxin substrate (1991) (25)
Augmented glucose-induced insulin release in mice lacking Go2, but not Go1 or Gi proteins (2011) (24)
A Minimal Set of Tissue-Specific Hypomethylated CpGs Constitute Epigenetic Signatures of Developmental Programming (2013) (24)
Heterotrimeric Gα(i) proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis. (2011) (24)
Reduced endoplasmic reticulum stress-induced apoptosis and impaired unfolded protein response in TRPC3-deficient M1 macrophages. (2014) (24)
TRPC3 channels play a critical role in the theta component of pilocarpine‐induced status epilepticus in mice (2017) (24)
The G protein-gated atrial K+ channel is stimulated by three distinct Gi alpha-subunits. (1988) (24)
Do canonical transient receptor potential channels mediate cholinergic excitation of cortical pyramidal neurons? (2013) (24)
The effect of estradiol on hormonally stimulable adenylyl cyclase activity and on progesterone production in normal and regressing corpora lutea from control and human chorionic gonadotropin-treated pseudopregnant rabbits. (1980) (24)
Modulation of human neuronal alpha 1E-type calcium channel by alpha 2 delta-subunit. (1998) (23)
Human‐Xenopus chimeras of Gsα reveal a new region important for its activation of adenylyl cyclase (1994) (23)
Absence of the Inhibitory G-Protein G&agr;i2 Predisposes to Ventricular Cardiac Arrhythmia (2010) (23)
Knockout of the Trpc1 gene reveals that TRPC1 can promote recovery from anaphylaxis by negatively regulating mast cell TNF-α production. (2013) (23)
The Loss of Gnai2 and Gnai3 in B Cells Eliminates B Lymphocyte Compartments and Leads to a Hyper-IgM Like Syndrome (2013) (23)
Transient Receptor Potential Canonical Type 3 Channels Control the Vascular Contractility of Mouse Mesenteric Arteries (2014) (23)
Crucial Role of TRPC1 and TRPC4 in Cystitis-Induced Neuronal Sprouting and Bladder Overactivity (2013) (22)
Human S31 serotonin receptor clone encodes a 5-hydroxytryptamine1E-like serotonin receptor. (1993) (22)
Developmental regulation of TRPC3 ion channel expression in the mouse cochlea (2010) (22)
Signaling through Gαi2 protein is required for recruitment of neutrophils for antibody‐mediated elimination of larval Strongyloides stercoralis in mice (2007) (22)
Direct G‐Protein Regulation of Ca2+ Channels (1989) (22)
Modulation of α2-Adrenoceptor Functions by Heterotrimeric Gαi Protein Isoforms (2009) (21)
Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice (2016) (21)
TRPC3 ion channel subunit immunolocalization in the cochlea (2010) (21)
Gonadotropin interactions with the gonad as assessed by receptor binding and adenylyl cyclase activity. (1977) (21)
TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation (2018) (21)
Studies on the mechanism of luteinizing hormone-induced desensitization of the rabbit follicular adenylyl cyclase system in vitro. (1981) (21)
A two-state model of an enzyme with an allosteric regulatory site capable of metabolizing the regulatory ligand. Simplified mathematical treatments of transient and steady state kinetics of an activator and its competitive inhibition as applied to adenylyl cyclases. (1980) (21)
TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes (2018) (21)
Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway. (2017) (20)
Evidence that Orai1 does not contribute to store-operated TRPC1 channels in vascular smooth muscle cells (2017) (20)
Subunit composition is a major determinant in high affinity binding of a Ca2+ channel blocker. (1996) (20)
Inactivation of the G alpha i2 and G alpha o genes by homologous recombination. (1997) (20)
Xenopus laevis oocyte Gα subunits mRNAs Detection and quantitation during oogenesis and early embryogenesis by competitive reverse PCR (1992) (20)
Carvacrol together with TRPC1 elimination improve functional recovery after traumatic brain injury in mice. (2012) (20)
Role of Src in C 3 transient receptor potential channel function and evidence for a heterogeneous makeup of receptor-and store-operated Ca 2 entry channels (2005) (20)
Complete reversal of run-down in rabbit cardiac Ca2+ channels by patch-cramming in Xenopus oocytes; partial reversal by protein kinase A (1999) (20)
TRPC1‐ and TRPC3‐dependent Ca2+ signaling in mouse cortical astrocytes affects injury‐evoked astrogliosis in vivo (2017) (20)
Gαi Proteins are Indispensable for Hearing (2018) (20)
The role of cGMP/cGKI signalling and Trpc channels in regulation of vascular tone. (2013) (20)
Reduced Necrosis and Content of Apoptotic M1 Macrophages in Advanced Atherosclerotic Plaques of Mice With Macrophage-Specific Loss of Trpc3 (2017) (20)
Effect of prolactin on luteal functions in the cyclic rat: positive correlation between luteinizing hormone-stimulated adenylyl cyclase activity and progesterone secretion; role in corpus luteum rescue of the morning surge of prolactin on day 3 of pseudopregnancy. (1980) (19)
Studies on the interaction of α subunits of GTP-binding proteins with βγ dimers (1992) (19)
TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential‐dependent coupling with PTEN (2019) (19)
Urea gradient/SDS-PAGE; a useful tool in the investigation of signal transducing G proteins. (1991) (19)
Specific Interaction of Gαi3 with the Oa1 G-Protein Coupled Receptor Controls the Size and Density of Melanosomes in Retinal Pigment Epithelium (2011) (19)
Gαi2- and Gαi3-Deficient Mice Display Opposite Severity of Myocardial Ischemia Reperfusion Injury (2014) (19)
Detergents, dimeric Gβγ, and eicosanoid pathways to muscarinic atrial K+ channels (1990) (19)
Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins. (2006) (19)
Naturally soluble component(s) that confer(s) guanine nucleotide and fluoride sensitivity to adenylate cyclase. (1980) (19)
P/Q‐type and T‐type calcium channels, but not type 3 transient receptor potential cation channels, are involved in inhibition of dendritic growth after chronic metabotropic glutamate receptor type 1 and protein kinase C activation in cerebellar Purkinje cells (2012) (19)
G protein coupling of receptors to ionic channels and other effector systems. (1990) (19)
Pertussis toxin-sensitive G proteins in regenerated endothelial cells of porcine coronary artery. (1994) (18)
From GTP and G proteins to TRPC channels: a personal account (2015) (18)
On the mode of action of catecholamines on the turkey erythrocyte adenylyl cyclase. Evaluation of basic activity states after removal of endogenous GDP and interpretation of nucleotide regulation and hormone activation in terms of a two-state model. (1980) (18)
Studies on receptor-mediated activation of adenylyl cyclases. V. Transient kinetics of the activation of beef renal medullary adenylyl cyclase by neurohypophyseal hormones: estimation of apparent rate constants of the receptor-hormone interaction. (1974) (17)
GTPases in Biology II (1993) (17)
Updated protocols and comments on the purification without use of activating ligands of the coupling proteins Ns and Ni of the hormone sensitive adenylyl cyclase. (1984) (17)
On the roles of Mg in the activation of G proteins (2010) (17)
A comparison of the influence of N-isopropyl and N-tert butyl substituents on the affinity of ligands for sinoatrial β-adrenoceptors in rat atria and β-adrenoceptors coupled to the adenylyl cyclase in kitten ventricle (1979) (17)
Canonical transient receptor potential channel subtype 3‐mediated hair cell Ca2+ entry regulates sound transduction and auditory neurotransmission (2013) (17)
Cloning of Trp1beta isoform from rat brain: immunodetection and localization of the endogenous Trp1 protein. (1999) (17)
Roles of Gi and Gq/11 in mediating desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes. (1999) (17)
Ca 21 -induced inhibition of the cardiac Ca 21 channel depends on calmodulin (heartyEF handyIQ motif) (1999) (17)
Effects of trypsin, protease inhibitors and ethanol on corpus luteum adenylyl cyclase. (1979) (17)
IEX-1 Deficiency Protects against Colonic Cancer (2012) (17)
Signaling Mechanism for Receptor-activated TRPC3 Channels (2003) (17)
Corpus luteum function and adenylyl cyclase stimulability in the rat after an estradiol benzoate-induced ovulatory surge of luteinizing hormone: role of prolactin. (1980) (17)
TRPC 3 and TRPC 6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells (2012) (17)
Glucagon-stimulable adenylyl cyclase in rat liver. Effects of chronic uremia and intermittent glucagon administration. (1984) (16)
Genetic disruption of G proteins, Gi2α or Goα, does not abolish inotropic and chronotropic effects of stimulating muscarinic cholinoceptors in atrium (2009) (16)
An essential role for Gαi2 in Smoothened-stimulated epithelial cell proliferation in the mammary gland (2015) (16)
Temporal characteristics of gonadotropin interaction with rabbit luteal receptors and activation of adenylyl cyclase: comparison to the mode of action of catecholamine receptors. (1982) (16)
The TRPC Family of Ion Channels: Relation to the TRP Superfamily and Role in Receptor- and Store-Operated Calcium Entry (2007) (16)
Desensitization of kitten atria to chronotropic, inotropic and adenylyl cyclase stimulating effects of (-)isoprenaline (1976) (16)
Factors affecting muscle glycogen synthetase activity. IV. Comparative study of the different dependent forms of glycogen synthetase. (1967) (16)
Dual activation of the cardiac Ca2+ channel α1C-subunit and its modulation by the β-subunit (1995) (15)
The in vivo regulation of heart rate in the murine sinoatrial node by stimulatory and inhibitory heterotrimeric G proteins (2013) (15)
Cholinergic stimulation of skeletal muscle alanine and glutamine formation and release. Evidence for mediation by a nicotinic cholinergic receptor and guanosine 3':5'-monophosphate. (1978) (15)
Guanosine 5'-O-(3-thiotriphosphate) causes endothelium-dependent, pertussis toxin-sensitive relaxations in porcine coronary arteries. (1992) (15)
Evidence for a regulated Ca2+ entry in proximal tubular cells and its implication in calcium stone formation (2019) (15)
Integration of TRPC6 and NADPH oxidase activation in lysophosphatidylcholine-induced TRPC5 externalization. (2017) (15)
Increased glomerular filtration rate and impaired contractile function of mesangial cells in TRPC6 knockout mice (2017) (15)
Homologous desensitization of the murine luteinizing hormone receptor expressed in L cells (1995) (15)
Abnormal guanine nucleotide regulatory protein in MVP dysautonomia: evidence from reconstitution of Gs. (1991) (15)
GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells (2020) (14)
Deletion of Go2α abolishes cocaine‐induced behavioral sensitization by disturbing the striatal dopamine system (2008) (14)
Giα proteins exhibit functional differences in the activation of ERK1/2, Akt and mTORC1 by growth factors in normal and breast cancer cells (2014) (14)
Purification of Ns and Ni, the coupling proteins of hormone-sensitive adenylyl cyclases without intervention of activating regulatory ligands. (1985) (14)
Decreased MAPK- and PGE2-dependent IL-11 production in Gialpha2-/- colonic myofibroblasts. (2007) (14)
Effects of estradiol treatment on rabbit luteal adenylyl cyclase: loss of luteinizing hormone receptors and attenuation of the regulatory N component activity. (1983) (14)
Does Erythropoietin Regulate TRPC Channels in Red Blood Cells? (2017) (14)
A surface on the G protein b-subunit involved in interactions with adenylyl cyclases (1997) (13)
Resistance to pathologic cardiac hypertrophy and reduced expression of CaV1.2 in Trpc3-depleted mice (2016) (13)
Coupling of Receptors to Adenylate Cyclases (1982) (13)
TRPC4 knockout mice: the coming of age of TRP channels as gates of calcium entry responsible for cellular responses. (2002) (13)
[Properties of the adenyl cyclase systems in liver and adipose cells: the mode of action of hormones]. (1970) (13)
TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice (2017) (12)
Gi proteins and the response to 5‐hydroxytryptamine in porcine cultured endothelial cells with impaired release of EDRF (1995) (12)
Reduced calcification and osteogenic features in advanced atherosclerotic plaques of mice with macrophage-specific loss of TRPC3. (2017) (12)
LH-induced desensitization of the adenylyl cyclase system in ovarian follicles. (1979) (12)
Reconstitution of the skeletal muscle dihydropyridine receptor. Functional interaction among alpha 1, beta, gamma and alpha 2 delta subunits. (1996) (12)
Lack of muscarinic regulation of Ca(2+) channels in G(i2)alpha gene knockout mouse hearts. (2001) (12)
Lipid-independent control of endothelial and neuronal TRPC3 channels by light† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc05536j (2019) (12)
Long lasting facilitation of the rabbit cardiac Ca2+ channel: correlation with the coupling efficiency between charge movement and pore opening (1998) (12)
Glycogen metabolism in muscle homogenates. I. The effect of potassium ions on glycogen synthesis. (1966) (11)
TRPC1 participates in the HSV-1 infection process by facilitating viral entry (2020) (11)
Expression of the alpha(2)delta subunit interferes with prepulse facilitation in cardiac L-type calcium channels. (2000) (11)
Angiotensin-II-Evoked Ca2+ Entry in Murine Cardiac Fibroblasts Does Not Depend on TRPC Channels (2020) (11)
Contribution of TRPC Channels in Neuronal Excitotoxicity Associated With Neurodegenerative Disease and Ischemic Stroke (2021) (11)
Activation of myocardial β-adrenoceptors by the nitrogen-free low affinity ligand 3′,4′-dihydroxy-α-methylpropiophenone (U-0521) (1977) (11)
Effects of withdrawal of exogenous estradiol from pseudopregnant rabbits: transient nature of loss of luteal function and reversal of estradiol-induced suppression of luteinizing hormone-responsive adenylyl cyclase. (1981) (11)
Detergents, dimeric G beta gamma, and eicosanoid pathways to muscarinic atrial K+ channels. (1990) (11)
Direct coupling of G proteins to ionic channels. (1988) (11)
Know thy neighbor: a survey of diseases and complex syndromes that map to chromosomal regions encoding TRP channels. (2007) (11)
16 – The Actions of Hormones and Nucleotides on Membrane-Bound Adenylyl Cyclases: An Overview (1977) (11)
Disruption of the Gi2α locus in embryonic stem cells and mice: a modified hit and run strategy with detection by a PCR dependent on gap repair (1993) (11)
Obligatory role in GTP hydrolysis for the amide carbonyl oxygen of the Mg2+-coordinating Thr of regulatory GTPases (2010) (11)
Deep Transcriptomic Profiling of M1 Macrophages Lacking Trpc3 (2017) (11)
Receptor-effector coupling by G proteins: purification of human erythrocyte Gi-2 and Gi-3 and analysis of effector regulation using recombinant alpha subunits synthesized in Escherichia coli. (1988) (11)
Murine cardiac growth, TRPC channels, and cGMP kinase I (2015) (11)
Analysis of Mrgprb2 Receptor-Evoked Ca2+ Signaling in Bone Marrow Derived (BMMC) and Peritoneal (PMC) Mast Cells of TRPC-Deficient Mice (2020) (11)
Agonist-specific desensitization: molecular locus and possible mechanism. (1981) (10)
Unique regulatory properties of the type 2a Ca 21 channel b subunit caused by palmitoylation (voltage-gated calcium channelsysignal transductionycalciumyXenopus oocytesyposttranslational modificationyprotein lipidationysplice variants) (1998) (10)
Purification of G proteins. (1991) (10)
Roles of G proteins and G protein subunits in signal transduction. (1990) (10)
Therapeutic targeting of hepatic ACSL4 ameliorates NASH in mice (2021) (10)
TRPC channels are not required for graded persistent activity in entorhinal cortex neurons (2019) (10)
Transient Receptor Potential Canonical 3 and Nuclear Factor of Activated T Cells C3 Signaling Pathway Critically Regulates Myocardial Fibrosis. (2019) (10)
Modulation of human neuronal a 1E -type calcium channel by a 2 d-subunit (1998) (10)
Functional coupling between human E‐type Ca2+ channels and μ opioid receptors expressed in Xenopus oocytes (1998) (9)
CHAPTER 213 – Signal Transduction by G Proteins—Basic Principles, Molecular Diversity and Structural Basis of Their Actions (2003) (9)
Multiple Roles of G Proteins in Coupling of Receptors to Ionic Channels and Other Effectors (1989) (9)
Characteristics of glucagon action on the hepatic adenylate cyclase system. (1971) (9)
Studies on the intrinsic activity (efficacy) of human adrenergic receptors. Co-expression of beta 1 and beta 2 reveals a lower efficacy for the beta 1 receptor. (1994) (9)
Gαi2+ vomeronasal neurons govern the initial outcome of an acute social competition (2020) (9)
TRPC3 determines osmosensitive [Ca2+]i signaling in the collecting duct and contributes to urinary concentration (2019) (9)
Synthesis, purification by HPLC and characterization of monoiodoglucagon labeled with carrier free 125I: use as glucagon receptor probe. (1983) (9)
Membrane depolarization combined with Gq-activated G-protein-coupled receptors induce transient receptor potential channel 1 (TRPC1)- dependent potentiation of catecholamine release (2011) (9)
Proceedings: Adrenergic receptors in heart muscle: similarity of apparent affinities of beta-blockers for receptors mediating adenyl-cyclase activity, inotropic and chronotropic effects of catecholamines. (1973) (8)
Heterotrimeric G proteins. Molecular diversity and functional correlates. (1993) (8)
Lack of Gαi2 leads to dilative cardiomyopathy and increased mortality in β1-adrenoceptor overexpressing mice. (2015) (8)
STE2/SCG1‐dependent inhibition of STE4‐induced growth arrest by mutant STE4ΔC6 in the yeast pheromone response pathway (1995) (8)
On the origins and present state of the art of G protein research. (1991) (8)
Reciprocal function of Gαi2 and Gαi3 in graft‐versus‐host disease (2008) (8)
Role for epithelial dysregulation in early‐onset colitis‐associated colon cancer in Gi2‐alpha−/− mice (2008) (8)
Skeletal muscle protein and amino acid metabolism in hereditary mouse muscular dystrophy. The role of disordered cyclic nucleotide metabolism in the accelerated alanine and glutamine formation and release. (1980) (8)
Heteromeric TRPV4/TRPC1 channels mediate calcium-sensing receptor-induced relaxations and nitric oxide production in mesenteric arteries: comparative study using wild-type and TRPC1−/- mice (2019) (8)
Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice (2019) (8)
Sensory Detection by the Vomeronasal Organ Modulates Experience-Dependent Social Behaviors in Female Mice (2021) (8)
Antibody response to dietary and autoantigens in Gαi2-deficient mice (2001) (8)
Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K+ currents in adult murine atria. (2018) (8)
RNA-seq analysis reveals TRPC genes to impact an unexpected number of metabolic and regulatory pathways (2020) (8)
Insulin-activated store-operated Ca2+ entry via Orai1 induces podocyte actin remodeling and causes proteinuria (2021) (8)
The human genome encodes at least three non-allellic G proteins with alpha i-type subunits. (1987) (7)
Hormonal regulation of pituitary GH3 cell K+ channels by Gk is mediated by its alpha-subunit. (1987) (7)
Studies on the interaction of alpha subunits of GTP-binding proteins with beta gamma dimers. (1992) (7)
Lysophosphatidic Acid-Activated Calcium Signaling Is Elevated in Red Cells from Sickle Cell Disease Patients (2021) (7)
[29] Targeted Inactivation of the G12α gene with replacement and insertion vectors: Analysis in a 96-well plate format (1994) (7)
Separate roles for N‐ and C‐termini of the STE4 (β) subunit of the Saccharomyces cerevisiae G protein in the mediation of the growth arrest. Lack of growth‐arresting activity of mammalian βγ complexes (1996) (7)
Control of K+ channels by G proteins (1991) (7)
Biochemical characterization of the adrenergic receptors: affinity labeling, purification, and reconstitution studies. (1985) (7)
Physiological Aspects of Appearance and Desensitization of Gonadotropin-Sensitive Adenylyl Cyclase in Ovarian Tissues and Membranes of Rabbits, Rats, and Pigs (1978) (7)
Identification of G protein-gated and G protein-modulated ionic channels. Molecular basis for G protein action. (1989) (7)
Assay for the glucagon receptor. (1985) (7)
Targeting of the Gi2α Gene in es cells with Replacement and Insertion Vectors (1993) (6)
Hyperactive Adverse Mechanical-Stress Responses in Dystrophic Heart are Coupled to TRPC6 and Blocked by cGMP-PKG Modulation (2014) (6)
Neutrophil Cyto‐Pharmaceuticals Suppressing Tumor Metastasis via Inhibiting Hypoxia‐Inducible Factor‐1α in Circulating Breast Cancer Cells (2021) (6)
The same mutation in Gsα and transducin α reveals behavioral differences between these highly homologous G protein α-subunits (2008) (6)
Prostaglandins do not appear to play a role in hCG-induced regression or desensitization of rabbit corpora lutea. (1981) (6)
Interactions among estrogen, prolactin and luteinizing hormone at the level of adenylyl cyclase in the corpus luteum: findings and physiological correlates. (1979) (6)
Antibody response to dietary and autoantigens in G alpha i2-deficient mice. (2001) (6)
Vascular smooth muscle TRPC3 channels facilitate the inverse hemodynamic response during status epilepticus (2020) (6)
[3H]PN200-110 binding in a fibroblast cell line transformed with the alpha 1 subunit of the skeletal muscle L-type Ca2+ channel. (1990) (6)
Hepatic IRF8 expression suppresses hepatocellular carcinoma progression and enhances the response to anti-PD-1 therapy. (2022) (6)
Effect of estradiol withdrawal on luteal hormone responsive adenylyl cyclase and luteal function in the pseudopregnant rabbit. (1980) (6)
TRPC3 and NALCN channels drive pacemaking in substantia nigra dopaminergic neurons (2021) (6)
Reconstitution of the β-adrenergic receptor (2005) (6)
The Retinal Basis of Light Aversion in Neonatal Mice (2022) (5)
Cocaine self-administration in mice with forebrain knock-down of trpc5 ion channels (2013) (5)
Modulation of Ca21 entry by polypeptides of the inositol 1,4,5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): Evidence for roles of TRP and IP3R in store depletion- activated Ca21 entry (1999) (5)
Networking ionic channels by G proteins. (1990) (5)
Molecular cloning and sequence determination of four different cDNA species coding for alpha-subunits of G proteins from Xenopus laevis oocytes. (1990) (5)
Chapter 1 G proteins and transmembrane signalling (1988) (5)
Screening of cDNA libraries with oligonucleotides as applied to signal transducing G proteins, receptors and effectors. (1988) (5)
Alpha-1 subunits of voltage gated Ca2+ channels in the mesencephalon × neuroblastoma hybrid cell line MES23.5 (1995) (5)
Implication of TRPC3 channel in gustatory perception of dietary lipids (2020) (5)
G protein-gated channels. A third major category of ionic channels. (1989) (5)
Heterotrimeric G‐protein subunit Gα i2 contributes to agonist‐sensitive apoptosis and degranulation in murine platelets (2018) (5)
Transcriptional signatures regulated by TRPC1/C4-mediated Background Ca2+ entry after pressure-overload induced cardiac remodelling. (2020) (5)
The role of Gα O‐mediated signaling in the rostral ventrolateral medulla oblongata in cardiovascular reflexes and control of cardiac ventricular excitability (2016) (5)
The TRP Family of Ion Channels (2008) (4)
Receptors and Hormone Action (2012) (4)
Requirement for Intramolecular Domain Interaction in Activation of G Protein a Subunit by Aluminum Fluoride and GDP but Not by GTPyS * (2001) (4)
Hormone action. Part I. Peptide hormones (1985) (4)
High affinity of carazolol for β-adrenoceptors coupled to the adenylyl cyclase in ventricular myocardium of kitten and xenopus laevis (1978) (4)
Lack of muscarinic regulation of Ca 2 1 channels in Gi 2 a gene knockout mouse hearts (2001) (4)
Modulation of the N-type calcium channel gene expression by the α subunit of Go (2003) (4)
Increased Vascular Smooth Muscle Contractility in TRPC6−/− Mice (2005) (4)
STRUCTURAL AND FUNCTIONAL PROPERTIES OF NS AND Ni, THE REGULATORY COMPONENTS OF ADENYLYL CYCLASES* (1985) (4)
Properties of human erythrocyte Ns and Ni, the regulatory components of adenylate cyclase, as purified without regulatory ligands. (1985) (4)
Lack of Gαi2 proteins in adipocytes attenuates diet-induced obesity (2020) (4)
The Adrenal Medulla (1990) (4)
Signal Transduction by G Protein-Coupled Receptors (1996) (4)
Adenylyl cyclases: stimulation by hormones and regulation by nucleotides**Supported in part by grants from the US Public Health Service (HD-06513, HD-06273, HD-09581 and HD-07495) and from the Clayton Foundation. (1977) (4)
Molecular and functional diversity of the TRPC family of ion channels. TRPC channels and their role in ROCE/SOCE (2006) (4)
Correction for Gao et al., Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response (2018) (4)
Colitis pathogenesis in Gai2 knockout mice depends on the presence of normal enteric flora and lymphocytes (2000) (3)
Inhibitory regulation of adenylyl cyclases. Evidence inconsistent with beta gamma-complexes of Gi proteins mediating hormonal effects by interfering with activation of Gs. (1987) (3)
Transient and Steady State Kinetics of the Interaction of Guanyl Nucleotides with the Adenylyl Cyclase System from Rat Liver Plasma (1980) (3)
The use of PCR to probe calcium channel diversity. (1991) (3)
Activation of myocardial beta-adrenoceptors by the nitrogen-free low affinity ligand 3',4'-dihydroxy-alpha-methylpropiophenone (U-0521). (1977) (3)
Regulation of ionic channels by G proteins. (1991) (3)
Targeted inactivation of the Gi2 alpha gene with replacement and insertion vectors: analysis in a 96-well plate format. (1994) (3)
The α‐subunit of the trimeric GTPase Go2 regulates axonal growth (2013) (3)
Molecular cloning and sequence determination of a cDNA coding for the alpha-subunit of a Go-type protein of Xenopus laevis oocytes. (1989) (3)
Hepatic interferon regulatory factor 8 expression suppresses hepatocellular carcinoma progression and enhances the response to anti–programmed cell death protein‐1 therapy (2022) (3)
Luteal adenylyl cyclase does not develop sensitivity to desensitization by human chorionic gonadotropin in the absence of nonluteal ovarian tissue. (1983) (3)
)Preparation of activated alpha subunits of Gs and Gis: from erythrocyte to activated subunit. (1994) (3)
A New Look at Receptor-Mediated Activation of a G-protein (1993) (2)
Gating of atrial muscarinic K+ channels by G proteins. (1990) (2)
[125I]iodopindolol: a new beta adrenergic receptor probe. (1981) (2)
Deletion of the trpc1 gene and the effects on locomotor and conditioned place-preference responses to cocaine (2012) (2)
Erratum: Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy (Proceedings of the National Academy of Sciences of the United States of America (2014) 111, 4, (1551-1556) doi:10.1073/pnas.1308963111) (2014) (2)
Cell-free membrane desensitization assay for G protein-coupled receptors. (2002) (2)
Ion channels and G proteins. (1989) (2)
Improved methods for determination of guanylyl cyclase activity and synthesis of [alpha-32P]GTP. (1979) (2)
Inhibition of adenylyl cyclase by hormones: structural and functional correlates. (1987) (2)
Reconstitution of the beta-adrenergic receptor. (1985) (2)
Modulation of K+ Channels by G-Proteins (1993) (2)
TRPC6 and TRPC1 functionally interact to mediate Ca2+ entry in endothelial cells to induce lung vascular permeability (2010) (2)
Ovarian Responsiveness to Gonadotropic Hormones (1980) (2)
Structural and regulatory properties of nucleotide binding regulatory N proteins of adenylate cyclase and their effects on hormone receptors (1984) (2)
Expression of the a2d Subunit Interferes with Prepulse Facilitation in Cardiac L-type Calcium Channels (2000) (2)
Receptor to Effector Signaling Through G-Proteins: βγ Dimers Join α Subunits in the World of Higher Eukaryotes (1993) (2)
Cation channel TRPC6 activation of TLR4 in endothelial cells mediates sepsis‐induced acute lung injury (2012) (2)
Ulcerative Colitis in Mice Lacking Gαi2 (1998) (1)
Targeting of the Gi2 alpha gene in ES cells with replacement and insertion vectors. (1993) (1)
TRPC absence induces pro-inflammatory macrophages and gut microbe disorder, sensitizing mice to colitis. (2022) (1)
Corrigendum to “TRPC3 channels critically regulate hippocampal excitability and contextual fear memory” Behav. Brain Res. 281(March) 2015, 69–77 (2017) (1)
Abnormal Gs function in mitral valve prolapse dysautonomia is not associated with abnormal alpha S cDNA sequence. (1991) (1)
Thymopentin improves the survival of septic mice by promoting the production of 15‐deoxy‐prostaglandin J2 and activating the PPARγ signaling pathway (2020) (1)
Molecular Diversity in Signal Transducing G-Proteins (1993) (1)
Inhibition of G α wi 2 activation by G α i 3 in CXCR 3-mediated signaling (2008) (1)
Canonical transient receptor potential 6 channel deficiency promotes smooth muscle cells dedifferentiation and increased proliferation after arterial injury (2020) (1)
Tight Coupling Between Charge Movement and Pore Opening in Type-e Calcium-Channel (2002) (1)
TRPC4 and GIRK channels underlie neuronal coding of firing patterns that reflect Gq/11–Gi/o coincidence signals of variable strengths (2022) (1)
The β-Adrenergic Receptor-Coupled Adenylate Cyclase: Reconstitution of the Functional Interactions of the Various Purified Components (1986) (1)
Endothelial TRPC1 and TRPC3 channels contribute to ATP‐mediated relaxation in mouse cerebral arteries (2011) (1)
SIN-1, a nitric oxide synthase donor, reduces isoproterenol-stimulated calcium current in both wild type and genetically engineered mouse hearts: findings from G protein subunit gene knockout mice (2002) (1)
Balance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic system (2018) (1)
Heteromeric TRPC1/TRPC4 channels play a critical role in epileptiform burst firing and seizure-induced neurodegeneration (2011) (1)
The Involvement of Gs in Regulation of the L-Type Voltage-Gated Ca2+ Channel (1993) (1)
Cooperative Control of Sensitivity by Two Splice Variants Of Go in Retinal Rod On-Bipolar Cells (2010) (1)
Hormonal Regulation of Adenylyl Cyclase Activity (1984) (1)
Extravasation of Leukocytes from Circulation is Controlled by Gαi2 Signaling Events in the Endothelium (2007) (1)
LH/hCG responsive adenylyl cyclase in rat testis and testes from testicular feminized male (Tfm) rats and mice; desensitization by homologous hormone. (1980) (1)
G protein coupling of receptors to ionic channels and other effector systems. (1990) (1)
Gs-activating receptors: modes of transmembrane signalling and genetic defects. (1993) (1)
Guanyl Nucleotide Regulation of the Liver Glucagon-Sensitive Adenylyl Cyclase System (1977) (1)
Genetic deletion of the TRPC3 channel blunts the development of angiotensin II‐induced hypertension in mice (2013) (0)
Evidence of in vivo exogen protein uptake by red blood cells: a putative therapeutic concept (2022) (0)
The Involvement of Adenylyl Cyclase And Cyclic Amp-Dependent Protein Kinases in Luteinizing Hormone Actions (2019) (0)
SIGNAL TRANSDUCING G PROTEINS, RECEPrORS AND EFFM-"IDRS (1988) (0)
TRPC3/6/7 Knockdown Protects the Brain from Cerebral Ischemia Injury via Astrocyte Apoptosis Inhibition and Effects on NF-кB Translocation (2016) (0)
P.19.9 Gαi2 signaling is required for skeletal muscle regeneration and for satellite cell differentiation (2013) (0)
Myristoylated alanine-rich C kinase substrate (MARCKS) mediates activation of canonical transient receptor potential 1 (TRPC1) channels in vascular myocytes (2013) (0)
Polarized but Differential Localization and Recruitment of STIM1, Orai1 and TRPC Channels in Secretory Cells (2011) (0)
Separate roles for N- and C-termini of the STE4 (beta) subunit of the Saccharomyces cerevisiae G protein in the mediation of the growth arrest. Lack of growth-arresting activity of mammalian beta gamma complexes. (1996) (0)
An indispensable role of TRPC6‐mediated Ca2+ entry in increasing lung microvascular permeability and acute lung injury (2008) (0)
Gi2, but not Gi3, signaling is required for eosinophil accumulation in allergic pulmonary inflammation* (2003) (0)
Role of TRPC3 channels in BDNF‐induced plasticity, hippocampal neuronal excitability and memory (2012) (0)
Abstract 138: Transient Receptor Potential Channel C1 Deficiency Protects the Murine Heart from Pressure Overload (2007) (0)
Very long openings of cardiac calcium channels exposed to FPL 64176 (1993) (0)
Vascular Cells Mechanism of Stretch-Induced Activation of the Mechanotransducer Zyxin (2012) (0)
The Actions of Nucleotides on Adenylyl Cyclase Systems (1976) (0)
Loss of the inhibitory GalphaO protein in the rostral ventrolateral medulla of the brainstem leads to abnormalities in cardiovascular reflexes and altered ventricular excitablitiy (2016) (0)
In Memoriam of Hector Torres (2013) (0)
TRPC6 Channel Mediated Calcium Entry Requires RhoA and Myosin Light Chain Kinase To Increase Lung Vascular Permeability. (2009) (0)
Title: Store-operated STIM1 translocation and interaction with TRPC1 at the plasma membrane stimulates PLC activity to induce channel gating in vascular smooth muscle cells (2016) (0)
Analysis of TRPC cation channels in haemostasis, thrombosis and platelet function (2016) (0)
Choline&c Stimulation of Skeletal Muscle Alanine and Glutamine Formation and Release (2012) (0)
Abnormal cerebellar development and gait in mice with a cerebellum-specific deletion of the α subunit of the heterotrimeric Go protein (2019) (0)
Transferring Ca-2+ dependent inactivation property from cardiac to neuronal Ca-2+ channels (1996) (0)
Cocaine self-administration in mice with forebrain knock-down of ion channels trpc 5 (2016) (0)
Corrections (2004) (0)
cap alpha. /sub i/-3 cDNA encodes the. cap alpha. subunit of G/sub k/, the stimulatory G protein of receptor-regulated K/sup +/ channels (1988) (0)
Defective Pheromone Sensing in Goα KO Mice (2012) (0)
The G lucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver (1999) (0)
Molecular G o 2 Regulates Vesicular Glutamate Transporter Activity by Changing Its Chloride Dependence (2005) (0)
Evidence for functional coupling of cGMP/cGKI signalling and TRPC channels in endothelium but not in vascular smooth muscle (2013) (0)
Evidence for functional coupling of cGMP/cGKI signalling and TRPC channels in endothelium but not in vascular smooth muscle (2013) (0)
On the Modes of Regulation of Intracellular Cyclic AMP: Desensitization of Adenylyl Cyclases to Hormonal Stimulation and Compartmentalization of Cyclic AMP (1976) (0)
In vivo chararcterization of the role of TRPC1 Channel in skeletal muscle function (2012) (0)
In vitro and in vivo chararcterization of the role of TRPC1 Channelin skeletal musclefunction (2011) (0)
Deletion of classical transient receptor potential 1, 3 and 6 alters pulmonary vasoconstriction in chronic hypoxia-induced pulmonary hypertension in mice (2022) (0)
XL (cid:1) s, the extra-long form of the (cid:1) -subunit of the Gs G protein, is significantly longer than suspected, and so is its companion Alex (2004) (0)
III. STIMULATION BY SECRETIN AND THE EFFECTS OF TRYPSIN ON THE RECEPTORS FOR LIPOLYTIC HORMONES (2011) (0)
Myoendothelial microdomains and TRPC3: anatomical links to function (2012) (0)
Efficacy of 81-adrenergic receptors is lower than that of fi 2-adrenergic receptors ( G protein / receptor-effector coupling / receptor subtypes / blocker selectivity ) (2005) (0)
receptor potential channel-deficient mice transient response and lung hyperresponsiveness in type 1 Severely blunted allergen-induced pulmonary Th2 cell (2012) (0)
223 THE ROLE OF INHIBITORY G PROTEIN GALPHAO-MEDIATED SIGNALLING IN THE CENTRAL NERVOUS MECHANISMS CONTROLLING SYMPATHETIC OUTFLOW TO THE HEART (2013) (0)
Acute effects of angiotensin II on calcium influx in the podocytes of the freshly isolated glomeruli of the wild type and TRPC6‐deficient mice (892.1) (2014) (0)
Gi2 plays a critical role in the short-term modulation of heart rate dynamics (2007) (0)
The effects of cardiac specific deletion of G??i2 and G??o on heart rate dynamics (2010) (0)
Loss of the classical transient receptor potential 3 partially protects from hypoxia-induced pulmonary hypertension in mouse (2020) (0)
TRP expression screening in DRG of CYPc rats. (2013) (0)
Channels + Mice Lacking Kir6.2-Containing ATP-Sensitive K Enhanced Neuronal Damage After Ischemic Insults in (2015) (0)
Activation Mechanisms and Molecular Properties of Cyclopiazonic Acid (CPA)-Evoked TRPC Channels in Vascular Myocytes from TRPC1-/- Mice (2011) (0)
Antagonism between Gαi2 and Gαi3 in CXCR3‐mediated signaling (2006) (0)
Cell Cycle , Cell Death , and Senescence IEX-1 De fi ciency Protects against Colonic Cancer (2012) (0)
Deletion of transient receptor potential canonical channel 1 prevents pulmonary vascular hyper‐permeability and edema formation secondary to cAMP activation of SPHK1 (847.4) (2014) (0)
Direct interaction of G (cid:98)(cid:103) with a C-terminal G (cid:98)(cid:103) -binding domain of the Ca 2 (cid:49) channel (cid:97) 1 subunit is responsible for channel inhibition by G protein-coupled receptors (1997) (0)
A wide range of pheromone-stimulated sexual and reproductive behaviors in female mice depend on G protein Gαo (2014) (0)
Purification, characterization and reconstitution of the adenylate cyclase-coupled β-adrenergic receptor (1984) (0)
Mice with conditional knockout of Galphai2 in the cardiac pacemaker system exhibit tachycardia with loss of HF power on HRV analysis (2012) (0)
The role of CD8+ T cells for development of colitis in Gαi2-deficient mice (1998) (0)
Regulatory functions - mechanisms of hormone action (1975) (0)
BulbSynapse in the Rat Main Olfactory Release at the Mitral/Tufted to Granule Cell Presynaptic Muscarinic Receptors Enhance Glutamate (2015) (0)
Mechanistic role of Gαo in striatal cAMP signal transduction (2020) (0)
Leucocyte trafficking (PP-028) (2010) (0)
Activation of calcium activated potassium calcium activated potassium channels from pig coronary artery by gtp gamma s may involve a g protein (1992) (0)
TRPC3 Regulates Islet Beta‐Cell Insulin Secretion (2023) (0)
Erratum: Expanded methyl-sensitive cut counting reveals hypomethylation as an epigenetic state that highlights functional sequences of the genome (Proceedings of the National Academy of Sciences of the United States of America (2002) 108:23 (9715-9720) DOI: 10.1073/pnas.1105713108) (2013) (0)
51Cardiac specific knockout of G-alpha-i2 in a murine model of heart failure (2014) (0)
Identification of the G-protein alpha-subunit encoded by alpha o2 cDNA as a 39 kDa pertussis toxin substrate. (1991) (0)
Inhibition of TRPC6 promotes capillary arterialization during post-ischemic blood flow recovery. (2022) (0)
Sustained ATP‐mediated vasodilation of cerebral arteries requires Ca2+ influx via TRPC3 channels to produce endothelial SKCa channel activation and hyperpolarization (2013) (0)
TRPC1 contribute to hypoxic pulmonary hypertension and right heart hypertrophy: evidence from TRPC1 knockout mice (2009) (0)
Increased glomerular filtration rate and impaired contractile function of mesangial cells in TRPC6 knockout mice (2017) (0)
TRPC3 channels are indispensible for oro-sensory perception of dietary lipids, and involved in obesity in mice and human (2018) (0)
Go1 is Required for the Signal Transduction in the ON-Bipolar Cell (2002) (0)
β Subunit Modulation of the Coupling between Charge Movement and Pore Opening in Calcium Channels (1997) (0)
The role of GalphaO-mediated signalling in the central nervous mechanisms controlling sympathetic outflow to the heart (2013) (0)
Giα proteins exhibit functional differences in the activation of ERK1/2, Akt and mTORC1 by growth factors in normal and breast cancer cells (2014) (0)
APB-Sensitive ON-Responses in ON-Bipolar Cells of GO1 Knockout Mice (2007) (0)
CORRECTIONS (2003) (0)
RNA-seq analysis reveals TRPC genes to impact an unexpected number of metabolic and regulatory pathways (2020) (0)
Model of Signal Transduction by G Proteins (1990) (0)
TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice (2017) (0)
Murine cardiac growth, TRPC channels, and cGMP kinase I (2014) (0)
Dihydropyridines, G Proteins, and Calcium Channels (1988) (0)
The beta cell expresses multiple subtypes of voltage-dependent calcium channels (1992) (0)
leukocyte extravasation G{alpha}i2-mediated signaling events in the endothelium are involved in controlling (2007) (0)
Heterotrimeric G-Proteins (2003) (0)
Melanopsin activates divergent phototransduction pathways in ipRGC subtypes (2022) (0)
P4-04-02: Smoothened Function as a G-Protein Coupled Receptor in Mammary Epithelial Cells. (2011) (0)
Gαi2 mediated signaling in mucosal immune homeostasis (2001) (0)
Molecular Diversity and Functional Considerations in Transmembrane Signalling by G Proteins (1993) (0)
Resistance to pathologic cardiac hypertrophy and reduced expression of CaV1.2 in Trpc3-depleted mice (2016) (0)
TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes (2017) (0)
on the Intrinsic Activity (Efficacy) of Human Adrenergic Receptors Co-Expression of P, and P2 Reveals a Lower Efficacy for the 1 Receptor (0)
Muscle wasting and repair after injury can be potentialy modulated by autologous growth factors combined with a TGF-b antagonist (2013) (0)
Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice (2019) (0)
From GTP and G proteins to TRPC channels: a personal account (2015) (0)
Lack of TRPC1 channels impairs skeletal muscle regeneration (2010) (0)
Guanyl nucleotide regulation of hormonally-responsive adenylyl cyclases, mol. cell. endocrinol. Joel Abramowitz, Ravi lyengar and Lutz Birnbaumer (1979) 16, 129–146 (1980) (0)
Inhibition of transient receptor potential cation channel 6 promotes capillary arterialization during post‐ischaemic blood flow recovery (2022) (0)
Tyrosine phosphorylation of STIM1 induced by TRPC6‐Pyk2 cascade regulates store‐operated calcium entry and endothelial permeability (2011) (0)
Vascular smooth muscle TRPC3 channels facilitate the inverse hemodynamic response during status epilepticus (2020) (0)
TRPC1 and TRPC6 Regulate Chronic Hypoxia‐induced Vascular Tone, Vasoreactivity and Pulmonary Hypertension (2013) (0)
The Canonical Trpc1 Channel Modulates Rod Signals in the Mammalian Retina (2009) (0)
Reactive Oxygen Species (ROS) mediate agonist‐induced TRPC6 activation in vascular smooth muscle cells (VSMCS) (2011) (0)
Jeffrey Friedman Receives Bristol-Myers Squibb Award for Metabolic Research (2001) (0)
Citation for the 2000 Distinguished Educator Award of The Endocrine Society to Dr. Stanley Korenman. (2000) (0)
Molecular diversity and functional correlates in transmembrane signaling by G proteins (1993) (0)
Molecular cloning and sequence determination of a cDNA coding for the a-subunit of a GO-type protein of Xenopus Zaevis oocytes (2001) (0)
Cloning and Expression of a Cardiac / Brain , 6 Subunit of the L-type Calcium Channel * (2001) (0)
POSTER SESSION 2, HRC 2013 (2013) (0)
Antagonism between G{alpha}i2 and G{alpha}i3 in CXCR3-mediated signaling (2006) (0)
SYNTHESIS, PURIFICATION BY HPLC AND ChARACTEKIZHTlON OE (1983) (0)
Modulation of the N-type calcium channel gene expression by the alpha subunit of Go. (2003) (0)
Transient receptor potential channel 6 knockdown prevents apoptosis of renal tubular epithelial cells upon oxidative stress via autophagy activation (2018) (0)
Reviewer Acknowledgments (2009) (0)
Gαi2-Deficient Mice Develop Ulcerative Colitis and Adenocarcinoma of the Colon (1996) (0)
A641 STIMULATION OF THE MICRO OPIOID RECEPTOR INHIBITS THE ACTIVITY OF THE NEURONAL E-TYPE Ca sup 2+ CHANNEL (1997) (0)
Canonical Trp Channels (Trpc1 and Trpc3) Regulate Neurotransmission And Visual Acuity In The Mouse Retina (2011) (0)
Seasonal variations in the responses of luteal and follicular luteinizing hormone-stimulated adenylyl cyclases to estradiol implants and implant removal in pseudopregnant rabbits. (1986) (0)
TRPC1‐Mediated Ca2+ Entry Increases Lung Microvascular Permeability (2009) (0)

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