Lynda Chin
#28,119
Most Influential Person Now
American dermatologist
Lynda Chin's AcademicInfluence.com Rankings
Lynda Chinmedical Degrees
Medical
#261
World Rank
#388
Historical Rank
#119
USA Rank
Dermatology
#6
World Rank
#9
Historical Rank
#3
USA Rank
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Medical
Lynda Chin's Degrees
- Doctorate Medicine Albert Einstein College of Medicine
- PhD Genetics Albert Einstein College of Medicine
Why Is Lynda Chin Influential?
(Suggest an Edit or Addition)According to Wikipedia, Lynda Chin is a Chinese-American medical doctor. She is a board-certified dermatologist who was the founding department chair and professor of genomic medicine at the University of Texas MD Anderson Cancer Center, as well as scientific director of the MD Anderson Institute for Applied Cancer Science. In late 2012 she was elected as a member of the Institute of Medicine of the National Academies.
Lynda Chin's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Comprehensive molecular portraits of human breast tumors (2012) (7791)
- Integrated Genomic Analyses of Ovarian Carcinoma (2011) (6411)
- Comprehensive molecular characterization of human colon and rectal cancer (2012) (6141)
- Comprehensive genomic characterization defines human glioblastoma genes and core pathways (2008) (5775)
- Comprehensive molecular characterization of gastric adenocarcinoma (2014) (4496)
- Comprehensive molecular profiling of lung adenocarcinoma (2014) (4095)
- Integrated genomic characterization of endometrial carcinoma (2013) (3708)
- The Somatic Genomic Landscape of Glioblastoma (2013) (3693)
- Comprehensive genomic characterization of squamous cell lung cancers (2012) (2998)
- Comprehensive genomic characterization of head and neck squamous cell carcinomas (2015) (2860)
- Malignant astrocytic glioma: genetics, biology, and paths to treatment. (2007) (2301)
- A Landscape of Driver Mutations in Melanoma (2012) (2244)
- Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. (2015) (2211)
- Genomic Classification of Cutaneous Melanoma (2015) (2143)
- The Molecular Taxonomy of Primary Prostate Cancer (2015) (2116)
- Integrated Genomic Characterization of Papillary Thyroid Carcinoma (2014) (2007)
- International network of cancer genome projects (2010) (1839)
- Comprehensive molecular characterization of urothelial bladder carcinoma (2014) (1748)
- Comprehensive molecular characterization of clear cell renal cell carcinoma (2013) (1724)
- Role of the INK4a Locus in Tumor Suppression and Cell Mortality (1996) (1675)
- The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53 (1998) (1637)
- A comprehensive catalogue of somatic mutations from a human cancer genome (2010) (1626)
- Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism (2012) (1527)
- Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma (2017) (1514)
- Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma (2016) (1474)
- Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer (2015) (1332)
- Molecular characterization of the tumor microenvironment in breast cancer. (2004) (1287)
- The genomic complexity of primary human prostate cancer (2010) (1195)
- Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. (2014) (1182)
- Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice (2000) (1101)
- Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma. (2017) (1092)
- FoxOs Are Lineage-Restricted Redundant Tumor Suppressors and Regulate Endothelial Cell Homeostasis (2007) (1038)
- p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis (1999) (973)
- Telomere dysfunction induces metabolic and mitochondrial compromise (2011) (960)
- Highly Recurrent TERT Promoter Mutations in Human Melanoma (2013) (948)
- CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells. (1994) (927)
- Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies (2007) (922)
- Essential role for oncogenic Ras in tumour maintenance (1999) (913)
- Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression (1997) (895)
- Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival. (2015) (890)
- Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas (2016) (826)
- Integrated genomic and molecular characterization of cervical cancer (2017) (762)
- Identification of Double-stranded Genomic DNA Spanning All Chromosomes with Mutated KRAS and p53 DNA in the Serum Exosomes of Patients with Pancreatic Cancer* (2014) (741)
- Melanoma genome sequencing reveals frequent PREX2 mutations (2012) (695)
- P53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation (2008) (687)
- Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade. (2016) (685)
- The somatic genomic landscape of chromophobe renal cell carcinoma. (2014) (646)
- Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas (2017) (577)
- Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. (2006) (567)
- Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance (2017) (555)
- Cancer genomics: from discovery science to personalized medicine (2011) (551)
- Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer (2014) (538)
- Emerging insights into the molecular and cellular basis of glioblastoma. (2012) (527)
- Prognostically relevant gene signatures of high-grade serous ovarian carcinoma. (2012) (509)
- A Genetic Screen for Candidate Tumor Suppressors Identifies REST (2005) (494)
- Malignant melanoma: genetics and therapeutics in the genomic era. (2006) (493)
- Melanoma: from mutations to medicine. (2012) (479)
- SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression (2011) (471)
- Emerging patterns of somatic mutations in cancer (2013) (450)
- High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. (2009) (433)
- Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis Gene (2006) (426)
- FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. (2009) (418)
- High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients. (2006) (416)
- Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation (1999) (416)
- High-resolution genomic profiles of human lung cancer. (2005) (412)
- Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers (2007) (405)
- LKB1 regulates quiescence and metabolic homeostasis of hematopoietic stem cells (2010) (399)
- An amino-terminal domain of Mxi1 mediates anti-myc oncogenic activity and interacts with a homolog of the Yeast Transcriptional Repressor SIN3 (1995) (395)
- Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse (1999) (394)
- A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations. (2017) (361)
- Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression. (2016) (357)
- Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. (2009) (351)
- Reprogramming of a melanoma genome by nuclear transplantation. (2004) (350)
- Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation (1998) (330)
- GOLPH3 modulates mTOR signaling and rapamycin sensitivity in cancer (2009) (330)
- Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma (2012) (327)
- An X Chromosome Gene, WTX, Is Commonly Inactivated in Wilms Tumor (2007) (326)
- Making sense of cancer genomic data. (2011) (326)
- Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation (2000) (308)
- Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution (2015) (307)
- Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion (2011) (298)
- Characterization of HPV and host genome interactions in primary head and neck cancers (2014) (296)
- Translating insights from the cancer genome into clinical practice (2008) (293)
- Passenger Deletions Generate Therapeutic Vulnerabilities in Cancer (2012) (292)
- The genetics of malignant melanoma: lessons from mouse and man (2003) (291)
- High-resolution characterization of the pancreatic adenocarcinoma genome (2004) (278)
- The INK4a/ARF locus and melanoma (2003) (263)
- Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration (2011) (263)
- Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer (2012) (258)
- Telomere dysfunction provokes regional amplification and deletion in cancer genomes. (2002) (253)
- Diverse Mechanisms of Somatic Structural Variations in Human Cancer Genomes (2013) (245)
- PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. (2010) (236)
- Post-translational Regulation of Cas9 during G1 Enhances Homology-Directed Repair. (2016) (220)
- Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities. (2006) (216)
- Spectrum of somatic mitochondrial mutations in five cancers (2012) (209)
- Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM (2010) (208)
- Telomerase Reactivation following Telomere Dysfunction Yields Murine Prostate Tumors with Bone Metastases (2012) (202)
- Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth (2016) (202)
- mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization (2008) (192)
- miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma (2015) (186)
- Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models. (2007) (184)
- PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network. (2011) (184)
- Integrative Genome Comparison of Primary and Metastatic Melanomas (2010) (179)
- p16(Ink4a) in melanocyte senescence and differentiation. (2002) (175)
- Dual Inactivation of RB and p53 Pathways in RAS-Induced Melanomas (2001) (175)
- Nuclear cloning of embryonal carcinoma cells. (2004) (172)
- Telomere dysfunction induces metabolic and mitochondrial compromise (2011) (168)
- The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. (2011) (167)
- Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma (2017) (166)
- Non-germline genetically engineered mouse models for translational cancer research (2010) (155)
- Amplification of CDK4 and MDM2 in malignant melanoma (2006) (152)
- Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer (2008) (152)
- High-Resolution Global Profiling of Genomic Alterations with Long Oligonucleotide Microarray (2004) (147)
- Characterization of melanocyte‐specific inducible Cre recombinase transgenic mice (2006) (146)
- Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. (2007) (144)
- Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma (2008) (140)
- Proinvasion metastasis drivers in early-stage melanoma are oncogenes. (2011) (140)
- The Somatic Genomic Landscape of Glioblastoma (2014) (135)
- HiCPlotter integrates genomic data with interaction matrices (2015) (135)
- Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling. (2008) (131)
- Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-Myc. (2009) (130)
- The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF. (2014) (130)
- Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer (2020) (128)
- Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development (2008) (126)
- Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice (2005) (123)
- Diverse Mechanisms of Somatic Structural Variations in Human Cancer Genomes (2014) (123)
- Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model (2003) (120)
- Inactivation of LEF1 in T-cell acute lymphoblastic leukemia. (2010) (120)
- Mig-6 controls EGFR trafficking and suppresses gliomagenesis (2010) (119)
- Lineage-Specific Transcriptional Regulation of DICER by MITF in Melanocytes (2010) (119)
- Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma. (2008) (117)
- Telomere dysfunction alters the chemotherapeutic profile of transformed cells (2001) (116)
- A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma. (2006) (113)
- Temporal control of neural crest lineage generation by Wnt/β-catenin signaling (2012) (110)
- Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo (2003) (110)
- microRNA regulatory network inference identifies miR-34a as a novel regulator of TGF-β signaling in glioblastoma. (2012) (107)
- STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA. (2012) (106)
- Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma (2017) (105)
- Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma. (2015) (101)
- In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer. (2016) (98)
- Temporal control of neural crest lineage generation by Wnt/beta-catenin signaling (2012) (97)
- Alu elements mediate MYB gene tandem duplication in human T-ALL (2007) (94)
- DNA amplification method tolerant to sample degradation. (2004) (93)
- Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer (2017) (92)
- Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia. (2010) (91)
- Characterization of immortal cystic fibrosis tracheobronchial gland epithelial cells. (1992) (91)
- Erratum: Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles (Cell Reports (2017) 18(11) (2780–2794) (S2211124717302140) (10.1016/j.celrep.2017.02.033)) (2017) (88)
- Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic amplicons. (2013) (85)
- Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome. (2015) (85)
- Signaling From the Golgi: Mechanisms and Models for Golgi Phosphoprotein 3–Mediated Oncogenesis (2010) (84)
- Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis (2010) (83)
- Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice. (2002) (81)
- Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice (2002) (80)
- Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor. (2010) (78)
- Chimeric mouse tumor models reveal differences in pathway activation between ERBB family– and KRAS-dependent lung adenocarcinomas (2010) (77)
- Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types. (2007) (74)
- Epigenetic transdifferentiation of normal melanocytes by a metastatic melanoma microenvironment. (2005) (73)
- A Role for ATF2 in Regulating MITF and Melanoma Development (2010) (73)
- Excessive tumor-elaborated VEGF and its neutralization define a lethal paraneoplastic syndrome (2001) (73)
- Targeting EGFR Induced Oxidative Stress by PARP1 Inhibition in Glioblastoma Therapy (2010) (71)
- A transformed human epithelial cell line that retains tight junctions post crisis (1992) (71)
- Mutant EGFR is required for maintenance of glioma growth in vivo, and its ablation leads to escape from receptor dependence (2010) (70)
- A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival. (2013) (70)
- Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma (2011) (69)
- Neutralization of terminal differentiation in gliomagenesis (2013) (68)
- Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression. (2017) (68)
- Role of Epidermal Growth Factor Receptor Signaling in RAS-Driven Melanoma (2005) (66)
- Towards patient-based cancer therapeutics (2010) (65)
- Balanced-PCR amplification allows unbiased identification of genomic copy changes in minute cell and tissue samples. (2004) (62)
- HOXA1 drives melanoma tumor growth and metastasis and elicits an invasion gene expression signature that prognosticates clinical outcome (2013) (61)
- A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases. (2018) (60)
- A comparison of DNA copy number profiling platforms. (2008) (59)
- What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator (2008) (57)
- Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer. (2015) (56)
- Genetics and genomics of melanoma. (2009) (56)
- PRKCI promotes immune suppression in ovarian cancer (2017) (55)
- Dual Roles of RNF2 in Melanoma Progression. (2015) (54)
- MTSS1 is a metastasis driver in a subset of human melanomas (2014) (54)
- Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma (2016) (53)
- In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time magnetic resonance imaging. (2005) (52)
- Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer. (2008) (49)
- Erratum: The somatic genomic landscape of glioblastoma (Cell (2013) 155 (462-477)) (2014) (49)
- Somatic Mutations of PIK3R1 Promote Gliomagenesis (2012) (48)
- Identification of a novel fusion gene, IRF2BP2-RARA, in acute promyelocytic leukemia. (2015) (48)
- Frequent met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis. (2006) (47)
- Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells. (2007) (47)
- Array comparative genome hybridization for tumor classification and gene discovery in mouse models of malignant melanoma. (2003) (46)
- The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models (2013) (45)
- BRAF Activation Initiates but Does Not Maintain Invasive Prostate Adenocarcinoma (2008) (44)
- Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1. (1996) (42)
- Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues (2002) (42)
- Erratum: Telomere dysfunction induces metabolic and mitochondrial compromise (Nature (2011) 470 (359-365)) (2011) (41)
- Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma. (2017) (41)
- Revealing the genomic heterogeneity of melanoma. (2005) (39)
- Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma (2016) (36)
- MAPK Pathway Inhibitors Sensitize BRAF-Mutant Melanoma to an Antibody-Drug Conjugate Targeting GPNMB (2016) (36)
- Flipping the oncogene switch: illumination of tumor maintenance and regression. (2000) (35)
- PAF promotes stemness and radioresistance of glioma stem cells (2017) (35)
- Applying Artificial Intelligence to Address the Knowledge Gaps in Cancer Care. (2018) (35)
- Induction of melanoma in murine macrophage inflammatory protein 2 transgenic mice heterozygous for inhibitor of kinase/alternate reading frame. (2001) (35)
- Identification and characterization of genes. (2002) (32)
- Disruption of the Cockayne Syndrome B Gene Impairs Spontaneous Tumorigenesis in Cancer-Predisposed Ink4a/ARF Knockout Mice (2001) (30)
- Chloride ion transport in transformed normal and cystic fibrosis epithelial cells. (1991) (29)
- An Inducible Melanoma Model Implicates a Role for RAS in Tumor Maintenance and Angiogenesis (2004) (28)
- Increased H3K9me3 drives dedifferentiated phenotype via KLF6 repression in liposarcoma. (2015) (26)
- Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice. (2005) (25)
- The Brothers RAF (2010) (24)
- Murine models of malignant melanoma. (2000) (24)
- Genetic dissection of melanoma pathways in the mouse. (2001) (24)
- Global impact of somatic structural variation on the DNA methylome of human cancers (2019) (21)
- Modeling malignant melanoma in mice: pathogenesis and maintenance (1999) (20)
- The metastasis problem gets stickier. (2009) (19)
- Chromosome 10, frequently lost in human melanoma, encodes multiple tumor-suppressive functions. (2014) (19)
- The Ink4a Tumor Suppressor Gene Product, p19 Arf , Interacts with MDM2 and Neutralizes (1998) (19)
- Integrative functional genomics identifies RINT1 as a novel GBM oncogene (2012) (18)
- Growth factors and oncogenes as targets in melanoma: lost in translation? (2007) (18)
- New approaches to the biology of melanoma: a workshop of the National Institutes of Health Pathology B Study Section. (2002) (18)
- A Comparison of DNA Copy Number Profiling Platforms (2007) (18)
- Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc (1999) (16)
- Inhibition of melanoma development in the Nras(Q61K)::Ink4a−/− mouse model by the small molecule BI‐69A11 (2013) (16)
- Preclinical evaluation of selective inhibitors of nuclear export (SINE) in basal-like breast cancer (BLBC). (2012) (14)
- Modeling Genomic Instability and Selection Pressure in a Mouse Model of Melanoma. (2017) (13)
- Advances in malignant melanoma: genetic insights from mouse and man. (2006) (13)
- Semiconductor-based DNA sequencing of histone modification states (2013) (13)
- A Genome-Wide Screen Reveals Functional Gene Clusters in the Cancer Genome and Identifies EphA 2 as a Mitogen in Glioblastoma (2006) (13)
- Absence of Biallelic TCR (cid:1) Deletion Predicts Early Treatment Failure in Pediatric T-Cell Acute Lymphoblastic Leukemia (2010) (12)
- Erratum: Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer (Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer (2014) 158(1) (185–197), (S0092867414007247), (10.1016/j.cell.2014.06.003)) (2019) (10)
- Abstract 4380: IACS-10759: A novel OXPHOS inhibitor which selectively kill tumors with metabolic vulnerabilities (2015) (8)
- Therapeutics , Targets , and Chemical Biology The RAC 1 P 29 S Hotspot Mutation in Melanoma Confers Resistance to Pharmacological Inhibition of RAF (2014) (8)
- Epigenetic Activation of WNT 5 A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth Graphical Abstract Highlights (2018) (7)
- Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer. (2016) (7)
- A systems biology approach to personalizing therapeutic combinations. (2013) (6)
- Clonal evolution of acute myeloid leukemia relapsed after 19 years of remission (2015) (6)
- MD Anderson's Oncology Expert Advisor powered by IBM Watson: A Web-based cognitive clinical decision support tool. (2014) (6)
- Extrachromosal DNA elements can drive disease evolution in glioblastoma (2016) (6)
- LAB-ANGIOGENESIS AND INVASION (2012) (6)
- Recapitulating human cancer in a mouse (2013) (6)
- Full complexity genomic hybridization on 60-mer oligonucleotide microarrays for array comparative genomic hybridization (aCGH). (2008) (6)
- Correction for Blelloch et al., Inaugural Article: Nuclear cloning of embryonal carcinoma cells, PNAS 2004 101:13985-13990 (2004) (6)
- Cancer Genomics in Clinical Context. (2015) (6)
- Effect of OH scavenging on the yield of radiation-induced DNA double-strand breaks in isolated nuclei. (1988) (6)
- Spatial Genome Organization as a Framework for Somatic Alterations in Human Cancer (2017) (5)
- Erratum: Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma (Ecography (2007) 21 (98-111)) (2007) (5)
- Comprehensive Genome-Wide Profile of Regional Gains and Losses in Multiple Myeloma Using Array-CGH: The 1q21 Amplification and Potential Role of the BCL-9 Gene in Multiple Myeloma Pathogenesis. (2004) (5)
- Effects of long term growth on tissue engineered cartilage (2003) (4)
- Increased H 3 K 9 me 3 drives dedifferentiated phenotype via KLF 6 repression in liposarcoma (2019) (4)
- Downregulation of Protection of Telomeres 1 expression in myelodysplastic syndromes with 7q deletion (2016) (4)
- Somatic Mutations of PIK 3 R 1 Promote Gliomagenesis (2012) (4)
- Polygenic in vivo validation of cancer mutations using transposons (2014) (3)
- Molecular and immune heterogeneity in synchronous melanoma metastases (2015) (3)
- Abstract A65: IACS-10759: A novel OXPHOS inhibitor that selectively kills tumors with metabolic vulnerabilities (2016) (3)
- Intra-patient intra-tumoral immune heterogeneity is evident at progression on targeted therapy and immunotherapy for melanoma (2014) (3)
- glioblastoma Bcl 2 L 12 inhibits post-mitochondrial apoptosis signaling in Material Supplemental (2006) (3)
- Prelinical evaluation of selective inhibitors of nuclear export (SINE) CRM1 (XPO1) inhibitors in prostate cancer (PrCa). (2012) (3)
- Corrigendum: Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma (2012) (3)
- Quantification of telomere length by FISH and laser scanning cytometry (2008) (2)
- Abstract LB-315: Comprehensive genomic characterization of cutaneous melanoma (2014) (2)
- A functional genomic approach to actionable gene fusions for precision oncology (2022) (2)
- Erratum: Nuclear cloning of embryonal carcinoma cells (Proceedings of the National Academy of Sciences of the United States of America (September 28, 2004) 101:39 (13985-13990)) (2004) (2)
- miR-34a as a novel regulator of TGFβ signaling in GBM (2012) (2)
- Abstract 3714: Characterization of a selective focal adhesion kinase (FAK) inhibitor in a panel of glioblastoma cell lines identify rational drug-drug combination strategies (2012) (2)
- Abstract LB-134: The identification and characterization of MLL2, an epigenetic enzyme, as a novel tumor suppressor in melanoma (2014) (1)
- Genomic and immune heterogeneity are associated with differential responses to therapy in melanoma (2017) (1)
- Polygenic in vivovalidation of cancer mutations using transposons (2014) (1)
- Clinical Relevance of Driver Mutations and Number of Driver Mutations in Patients with Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia (2016) (1)
- ApricityRx companion digital therapeutic for evidence-based mitigation and phenotype-linked molecular characterization of irAEs in patients receiving immune checkpoint therapy (ICT). (2020) (1)
- genesis through cyclin E and notch signaling Inhibitor of differentiation 4 drives brain tumor-initiating cell (2008) (1)
- Abstract 2972: Genomic classification of cutaneous melanoma (2015) (1)
- Corrigendum: Passenger deletions generate therapeutic vulnerabilities in cancer (2015) (1)
- OMICS AND PROGNSTIC MARKERS (2013) (1)
- Correction: Targeting EGFR Induced Oxidative Stress by PARP1 Inhibition in Glioblastoma Therapy (2011) (1)
- Omics and Prognostic Markers (2010) (1)
- Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer (2020) (1)
- Abstract 71: Cas9 protein engineering for cell cycle-specific genome editing to enhance homology directed repair (2016) (1)
- Molecular Insights in Patient Care Identification of a Novel Fusion Gene , IRF 2 BP 2-RARA , in Acute Promyelocytic Leukemia (2015) (1)
- Abstract A9: The pancreatic ductal adenocarcinoma project at the Ontario Institute for Cancer Research. (2012) (0)
- Cancer Genomics in the Clinic: Methods and Lessons (2013) (0)
- Integrated genomic characterization of oesophageal carcinoma (2017) (0)
- 974 Selective Inhibitors of Nuclear Export (SINE) CRM1 (XPO1) Antagonists Activate Multiple Tumor Suppressor Pathways and Kill Prostate Cancer (PrCa) Cells (2012) (0)
- Absence of T-Cell Receptor Gene Rearrangements Predicts Induction Failure in Pediatric T-Cell Acute Lymphoblastic Leukemia. (2009) (0)
- Abstract LB-228: The identification of recurrent non-coding mutations in melanoma. (2013) (0)
- ModelingGenomic Instabi lity andSelectionPressure in a Mouse Model of Melanoma Graphical Abstract Highlights (2017) (0)
- Contents continued (2023) (0)
- The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models (2013) (0)
- Identification of a cryptic IRF2BP2-RARA fusion in acute promyelocytic leukemia (2018) (0)
- A Mouse Model of Telomere Dysfunction Recapitulates Hallmark Features of Human Myelodysplastic Syndrome (2014) (0)
- Abstract 4455: Relapsed/refractory AML responds robustly to IACS-10759, a novel OXPHOS inhibitor (2015) (0)
- Abstract LB-154: Loss of PTEN cooperates with activated RAS in melanoma genesis and progression (2010) (0)
- Abstract A37: Anti-telomerase therapy provokes ALT and mitochondrial adaptive mechanism in cancer (2012) (0)
- Abstract B13: Modeling BRAF inhibitor resistance in genetically engineered mouse models of melanoma (2012) (0)
- Targeting YAP-dependent MDSC infiltration impairs tumor progression (2015) (0)
- The Role for ink4a in Melanoma Pathogenesis (1998) (0)
- Abstract PR06: A co-clinical assessment of patterns of BRAF inhibitor resistance (2015) (0)
- Keynote address: Translating the cancer genomes (2011) (0)
- Genome engineering - Matching supply with demand (2016) (0)
- Global impact of somatic structural variation on the DNA methylome of human cancers (2019) (0)
- Role of the Epigenetic Modifier EZH2 in Melanoma (2013) (0)
- Identification of Kruppel-Like Factor 6 (KLF6) as a Differentially Expressed Transcription Factor and Tumor Suppressor in Well Differentiated and Dedifferentiated Liposarcoma (WDLPS, DDLPS) through Unbiased Epigenetic Approaches (2014) (0)
- Abstract 4314: Chromatin state alterations during melanoma progression (2018) (0)
- HiCPlotter integrates genomic data with interaction matrices (2015) (0)
- treatmentastrocytic glioma: genetics, biology, and paths to (2008) (0)
- Abstract 1301: Inter- and intra-tumoral immune and genomic heterogeneity in patients with metastatic melanoma (2015) (0)
- Abstract 2392: Genomic and immune heterogeneity in synchronous melanoma metastases is associated with differential tumor growth and response to therapy (2016) (0)
- Abstract IA24: YAP in cancer and inflammation (2020) (0)
- Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer (2014) (0)
- Abstract LB-45: Multiple melanoma suppressors are downregulated by loss of human chromosome 10. (2013) (0)
- Abstract IA15: Functional diversity of the pancreas tumor stroma (2016) (0)
- The Evolving Genomic Landscape of Recurrent Gliomas (2015) (0)
- AI-01. CAIX REGULATION OF EXTRACELLULAR PH AND INVASION IN GLIOBLASTOMA (2012) (0)
- Alexei Cancer Exosomes of Patients with Pancreatic Mutated KRAS and p 53 DNA in the Serum DNA Spanning all Chromosomes with Identification of Double Stranded Genomic Report (2013) (0)
- The BCL11B Tumor Suppressor Is Mutated In Human T-Cell Acute Lymphoblastic Leukemia (2010) (0)
- Abstract 5056: A glimpse into the somatic mutation landscape of melanoma through exome sequencing of 121 tumor-normal pairs (2012) (0)
- Corrections and Retraction (2004) (0)
- The Biology and Genetics of Melanoma (2006) (0)
- Abstract PR09: Genetic interaction of NEDD9 with melanoma-prone oncogenes and tumor suppressor genes (2014) (0)
- THE P53 PATHWAY AND ANCESTRAL PROGENITORS ARE ASSOCIATED WITH TUMOR RECURRENCE IN GLIOBLASTOMA (2014) (0)
- Abstract 1107: MicroRNA-182 acts as a chemosensitizer in GBM by repressing Bcl2L12 (2012) (0)
- Murine models of malignant (2000) (0)
- Abstract 2856: Preclinical therapeutics in genetically engineered mouse models of inducible NRAS and BRAF mutant melanoma (2011) (0)
- The role of EGFR* signaling pathway for tumor maintenance and alternative pathways in glioblastoma which enhance tumor growth (2006) (0)
- A digital therapeutic for proactive monitoring of patients on immune checkpoint inhibitor therapy for early detection of immune-related adverse events. (2020) (0)
- Abstract B131: A prioritization pipeline for functionally annotating oncogenic somatic driver aberrations in cancer. (2013) (0)
- Large Scale Copy Number Variation Upregulates the Expression of MYB in Human T-ALL. (2006) (0)
- The familial melanoma gene, INK4a, cooperates with activated RAS in development of melanoma: A mouse model (1998) (0)
- Abstract 949: Identification of OXPHOS inhibitors which selectively kill tumors with specific metabolic vulnerabilities (2014) (0)
- subtypes of T-cell acute lymphoblastic leukemia tumor suppressor is mutated across the major molecular BCL11B The (2013) (0)
- Abstract B130: The intratumoral heterogeneity of glioblastoma suggests a pivotal role for clonal evolution. (2013) (0)
- Abstract 2841: A co-clinical assessment of patterns of BRAF inhibitor resistance (2015) (0)
- Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma (2018) (0)
- Tackling "big data" for accelerating cancer research. (2016) (0)
- Abstract 984: Alteration of the p53 pathway is associated with subclonal tumor progression in glioblastoma (2014) (0)
- GE-17ALTERATION OF THE p53 PATHWAY AND ANCESTRAL PROGENITORS ARE ASSOCIATED WITH TUMOR RECURRENCE IN GLIOBLASTOMA (2014) (0)
- Translating the Cancer Genome: going beyond p values (2008) (0)
- Abstract 3925: Characterization of complex chromosomal aberrations in prostate cancer from whole genome sequencing (2011) (0)
- Corrections and Retraction: Characterization of Immortal Cystic Fibrosis Tracheobroncial Gland Epithelial Cells (1992) (0)
- Integrative comparative oncogenomics of mouse and human tumors (2008) (0)
- Comprehensivemolecularcharacterization of human colon and rectal cancer (2012) (0)
- Abstract PR6: Resistance to EGFR inhibition via the emergence of EGFRvIII-independent tumor growth-promoting mechanisms in glioblastoma (2010) (0)
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