Lynne Regan

Q: What Schools Are Affiliated With Lynne Regan

Lynne Regan is affiliated with the following schools: University of Sussex, Yale University, Imperial College London, University of Oxford, University of Edinburgh, Massachusetts Institute of Technology, University of Cambridge

Lynne Regan's AcademicInfluence.com Rankings

Lynne Regan

Chemistry

#3375

World Rank

#4390

Historical Rank

Organic Chemistry

#757

World Rank

#854

Historical Rank

chemistry Degrees

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Chemistry

Why Is Lynne Regan Influential?

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According to Wikipedia, Lynne Regan is a Professor of Biochemistry and Biotechnology at the School of Biological Sciences at the University of Edinburgh. Previously, she was a Professor of Molecular Biophysics and Biochemistry at Yale University. She was the president of the Protein Society for the 2013–2014 term and has earned many awards throughout her career. Her research mainly concerns interactions between proteins and nucleic acids.

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Lynne Regan's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

TPR proteins: the versatile helix. (2003) (1076)
Antiparallel Leucine Zipper-Directed Protein Reassembly: Application to the Green Fluorescent Protein (2000) (486)
Characterization of a helical protein designed from first principles. (1988) (458)
Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)‐domain co‐chaperones (1999) (428)
Structure and function of KH domains (2008) (406)
Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: scope and mechanism. (2005) (405)
A thermodynamic scale for the beta-sheet forming tendencies of the amino acids. (1994) (365)
A general model for amyloid fibril assembly based on morphological studies using atomic force microscopy. (2003) (284)
Design of stable alpha-helical arrays from an idealized TPR motif. (2003) (264)
A systematic exploration of the influence of the protein stability on amyloid fibril formation in vitro. (2000) (230)
Protein–protein interactions: General trends in the relationship between binding affinity and interfacial buried surface area (2013) (218)
Guidelines for Protein Design: The Energetics of β Sheet Side Chain Interactions (1995) (211)
An inverse correlation between loop length and stability in a four-helix-bundle protein. (1997) (176)
What makes a protein a protein? Hydrophobic core designs that specify stability and structural properties (1996) (173)
The interface of protein structure, protein biophysics, and molecular evolution (2012) (171)
Protein alchemy: Changing β-sheet into α-helix (1997) (159)
A tetrahedral zinc(II)-binding site introduced into a designed protein. (1990) (155)
Modular arrangement of functional domains along the sequence of an aminoacyl tRNA synthetase (1983) (140)
Detecting protein-protein interactions with GFP-fragment reassembly (2004) (131)
The folding and design of repeat proteins: reaching a consensus. (2003) (128)
Inhibition of Spontaneous Receptor Phosphorylation by Residues in a Putative α-Helix in the KIT Intracellular Juxtamembrane Region* (1999) (128)
Construction and Design of ‚-Sheets (1997) (128)
A new folding paradigm for repeat proteins. (2005) (127)
Protein design: novel metal-binding sites. (1995) (126)
The design of metal-binding sites in proteins. (1993) (123)
A recurring theme in protein engineering: the design, stability and folding of repeat proteins. (2005) (122)
Redesigning the hydrophobic core of a four‐helix‐bundle protein (1994) (117)
Ligand binding by repeat proteins: natural and designed. (2008) (114)
A novel class of small molecule inhibitors of Hsp90. (2008) (105)
Balance between folding and degradation for Hsp90-dependent client proteins: a key role for CHIP. (2010) (100)
Stimuli-responsive smart gels realized via modular protein design. (2010) (98)
Designed TPR modules as novel anticancer agents. (2008) (97)
Dissecting RNA-protein interactions: RNA-RNA recognition by Rop (1995) (97)
Ligand binding by TPR domains (2006) (93)
Novel metal-binding proteins by design (1995) (92)
Structure and stability of designed TPR protein superhelices: unusual crystal packing and implications for natural TPR proteins. (2007) (91)
Local and long-range stability in tandemly arrayed tetratricopeptide repeats. (2005) (89)
Amino-acid substitutions in a surface turn modulate protein stability (1996) (89)
A Thermodynamic Scale for the , & Sheet Forming Tendencies of the Amino Acids (1993) (86)
Identification of residues on Hsp70 and Hsp90 ubiquitinated by the cochaperone CHIP. (2010) (86)
Sidechain interactions in parallel beta sheets: the energetics of cross-strand pairings. (1999) (85)
Sequence variation in ligand binding sites in proteins (2005) (83)
Beyond consensus: statistical free energies reveal hidden interactions in the design of a TPR motif. (2004) (83)
A uniform survey of allele-specific binding and expression over 1000-Genomes-Project individuals (2016) (78)
Revisiting the Ramachandran plot from a new angle (2011) (78)
Absence of scaling for the intermediate scattering function of a hard-sphere suspension: static and dynamic x-ray scattering from concentrated polystyrene latex spheres. (2000) (73)
Protein design to understand peptide ligand recognition by tetratricopeptide repeat proteins. (2004) (73)
The role of backbone conformational heat capacity in protein stability: Temperature dependent dynamics of the B1 domain of Streptococcal protein G (2000) (71)
Fragile X mental retardation syndrome: structure of the KH1-KH2 domains of fragile X mental retardation protein. (2007) (65)
Aromatic rescue of glycine in β sheets (1998) (64)
The past, present and future of protein-based materials (2018) (61)
Protein alchemy: changing beta-sheet into alpha-helix. (1997) (58)
Reengineering Granulocyte Colony-stimulating Factor for Enhanced Stability* (2001) (58)
Using loop length variants to dissect the folding pathway of a four-helix-bundle protein. (1999) (57)
A compound that inhibits the HOP-Hsp90 complex formation and has unique killing effects in breast cancer cell lines. (2011) (56)
Speeding up protein folding: mutations that increase the rate at which Rop folds and unfolds by over four orders of magnitude. (1997) (52)
Understanding the sequence determinants of conformational switching using protein design (2000) (52)
Screening libraries to identify proteins with desired binding activities using a split-GFP reassembly assay. (2010) (51)
Consensus design as a tool for engineering repeat proteins. (2006) (51)
The de novo design of a rubredoxin‐like fe site (1998) (50)
Polypeptide sequences essential for RNA recognition by an enzyme. (1987) (50)
Electrostatic Interactions of Hsp-organizing Protein Tetratricopeptide Domains with Hsp70 and Hsp90 (2009) (49)
Redesigning the topology of a four-helix-bundle protein: monomeric Rop. (1995) (49)
An AlphaScreenTM-Based High-Throughput Screen to Identify Inhibitors of Hsp90-Cochaperone Interaction (2009) (48)
Dispensable pieces of an aminoacyl tRNA synthetase which activate the catalytic site (1984) (48)
Dramatic structural and thermodynamic consequences of repacking a protein's hydrophobic core. (2000) (48)
A Direct Interaction between the Utp6 Half-a-Tetratricopeptide Repeat Domain and a Specific Peptide in Utp21 Is Essential for Efficient Pre-rRNA Processing (2008) (47)
Surface point mutations that significantly alter the structure and stability of a protein's denatured state (1996) (46)
Characterization of metal binding by a designed protein: single ligand substitutions at a tetrahedral Cys2His2 site. (1995) (46)
Guidelines for protein design: the energetics of beta sheet side chain interactions. (1995) (45)
A modular approach to the design of protein‐based smart gels (2012) (44)
Designed proteins to modulate cellular networks. (2010) (44)
Engineering and design. (2003) (42)
Kinetics and thermodynamics of phenotype: unwinding and rewinding the nucleosome. (2012) (42)
Transmuting α helices and β sheets (1997) (42)
Crystal structure of a designed tetratricopeptide repeat module in complex with its peptide ligand (2010) (42)
Calorimetric study of a series of designed repeat proteins: Modular structure and modular folding (2011) (41)
Modulating repeat protein stability: The effect of individual helix stability on the collective behavior of the ensemble (2011) (41)
Protein design: Past, present, and future (2015) (39)
Redesign of a protein–peptide interaction: Characterization and applications (2009) (39)
Non-random-coil behavior as a consequence of extensive PPII structure in the denatured state. (2008) (38)
Nanostructured functional films from engineered repeat proteins (2013) (38)
Combinatorial approaches to protein stability and structure. (2004) (37)
Covariation of backbone motion throughout a small protein domain (2003) (35)
Secondary ligands enhance affinity at a designed metal-binding site. (1999) (35)
A new bright green‐emitting fluorescent protein – engineered monomeric and dimeric forms (2010) (35)
Two mutations in the dispensable part of alanine tRNA synthetase which affect the catalytic activity. (1985) (35)
The design of a four-helix bundle protein. (1987) (34)
Mapping the energy landscape of repeat proteins using NMR-detected hydrogen exchange. (2008) (34)
New insights into Fragile X syndrome (2005) (33)
All repeats are not equal: a module-based approach to guide repeat protein design. (2013) (33)
HOP is a monomer: Investigation of the oligomeric state of the co‐chaperone HOP (2010) (31)
New materials from proteins and peptides. (2012) (31)
Modulating Protein Folding Rates in Vivo and in Vitro by Side-chain Interactions between the Parallel β Strands of Green Fluorescent Protein* (2000) (30)
The power of hard-sphere models: explaining side-chain dihedral angle distributions of Thr and Val. (2012) (29)
Reassembled GFP: detecting protein-protein interactions and protein expression patterns. (2005) (29)
Protein-Based Hydrogels for Tissue Engineering. (2016) (28)
Proteomics of Mycoplasma genitalium: identification and characterization of unannotated and atypical proteins in a small model genome. (2000) (27)
Design of Protein-Peptide Interaction Modules for Assembling Supramolecular Structures in Vivo and in Vitro. (2015) (27)
The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes (2014) (27)
A cell-based screen for function of the four-helix bundle protein Rop: a new tool for combinatorial experiments in biophysics. (2004) (26)
Aromatic rescue of glycine in beta sheets. (1998) (26)
ColE1-compatible vectors for high-level expression of cloned DNAs from the T7 promoter. (1994) (25)
The crystal structure of NlpI (2004) (25)
LIVE-PAINT allows super-resolution microscopy inside living cells using reversible peptide-protein interactions (2020) (25)
A twisted four-sheeted model for an amyloid fibril. (2005) (25)
A new method for the covalent attachment of DNA to a surface for single-molecule studies. (2011) (24)
Creating novel proteins by combining design and selection. (2010) (24)
Protein design on computers. Five new proteins: Shpilka, grendel, fingerclasp, leather, and aida (1992) (23)
Does the location of a mutation determine the ability to form amyloid fibrils? (2002) (23)
Designed Phosphoprotein Recognition in Escherichia coli (2014) (23)
Disulfide crosslinks to probe the structure and flexibility of a designed four‐helix bundle protein (1994) (22)
Comparison of protein backbone entropy and beta-sheet stability: NMR-derived dynamics of protein G B1 domain mutants. (2001) (22)
Protein Structure: Born to be beta (1994) (22)
Fabrication of Modularly Functionalizable Microcapsules Using Protein-Based Technologies. (2016) (21)
Predicting the side‐chain dihedral angle distributions of nonpolar, aromatic, and polar amino acids using hard sphere models (2014) (21)
NextGen protein design. (2013) (20)
A prokaryotic tetratricopeptide repeat protein with a globular fold (2005) (20)
A bacterial and silkworm aminoacyl-tRNA synthetase have a common epitope which maps to the catalytic domain of each. (1986) (19)
Random close packing in protein cores. (2015) (18)
Intrinsic α‐helical and β‐sheet conformational preferences: A computational case study of alanine (2014) (17)
Repeat motions and backbone flexibility in designed proteins with different numbers of identical consensus tetratricopeptide repeats. (2006) (17)
Site-specific protein double labeling by expressed protein ligation: applications to repeat proteins. (2012) (17)
Construction and Design of β-Sheets (1997) (17)
A new method for post-translationally labeling proteins in live cells for fluorescence imaging and tracking (2017) (16)
Mutations in the B1 domain of protein G that delay the onset of amyloid fibril formation in vitro (2003) (15)
Protein redesign. (1999) (15)
Packing in protein cores (2017) (14)
Probing the Molecular Origin of Native-State Flexibility in Repeat Proteins. (2015) (14)
Crystallization of a small fragment of an aminoacyl tRNA synthetase. (1988) (13)
White and green screening with circular polymerase extension cloning for easy and reliable cloning (2013) (13)
New insights into the interdependence between amino acid stereochemistry and protein structure. (2013) (13)
Promoting convergence: The integrated graduate program in physical and engineering biology at Yale University, a new model for graduate education (2016) (13)
Proteins to order? (1998) (13)
Rationale for engineering an enzyme by introducing a mutation that compensates for a deletion. (1988) (11)
Molten globules move into action (2003) (11)
A structural model for the HAT domain of Utp6 incorporating bioinformatics and genetics. (2009) (11)
Practical axial optical trapping. (2012) (11)
Characterization of folding the four-helix bundle protein Rop by real-time NMR. (2008) (11)
Steric interactions determine side-chain conformations in protein cores. (2016) (10)
Conservation of mechanism, variation of rate: folding kinetics of three homologous four-helix bundle proteins. (2008) (10)
Collective repacking reveals that the structures of protein cores are uniquely specified by steric repulsive interactions (2017) (9)
Facile Protein Immobilization Using Engineered Surface-Active Biofilm Proteins (2018) (9)
Flat Drops, Elastic Sheets, and Microcapsules by Interfacial Assembly of a Bacterial Biofilm Protein, BslA. (2017) (9)
Analyses of protein cores reveal fundamental differences between solution and crystal structures. (2019) (9)
Unwinding and rewinding the nucleosome inner turn: force dependence of the kinetic rate constants. (2012) (9)
Understanding the physical basis for the side‐chain conformational preferences of methionine (2016) (8)
Routes to DNA accessibility: alternative pathways for nucleosome unwinding. (2014) (8)
Analysis of side chain mobility among protein G B1 domain mutants with widely varying stabilities (2004) (8)
Transmuting alpha helices and beta sheets. (1997) (8)
PAINT using proteins: A new brush for super‐resolution artists (2020) (7)
Transmuting a helices and b sheets (1997) (7)
Comparison of the backbone dynamics of a natural and a consensus designed 3-TPR domain (2008) (7)
Comparing side chain packing in soluble proteins, protein‐protein interfaces, and transmembrane proteins (2018) (7)
Protein engineering and design: from first principles to new technologies. (2010) (6)
Void distributions reveal structural link between jammed packings and protein cores. (2018) (6)
Condensation transition and forced unravelling of DNA-histone H1 toroids: a multi-state free energy landscape (2015) (6)
Erratum: Novel metal-binding proteins by design (Nature Structural Biology (1995) 2 (1995) (368-373)) (1995) (6)
Designed Proteins as Novel Imaging Reagents in Living Escherichia coli (2016) (5)
Allosteric conformational spread: exact results using a simple transfer matrix method. (2010) (5)
Reads meet rotamers: structural biology in the age of deep sequencing. (2015) (5)
What determines where alpha-helices begin and end? (1993) (5)
Library approaches to biophysical problems. (2004) (5)
Equilibrium transitions between side‐chain conformations in leucine and isoleucine (2015) (5)
A designed repeat protein as an affinity capture reagent. (2015) (4)
Studying α-helix and β-sheet formation in small proteins (1995) (4)
Acute intermittent porphyria. (1999) (4)
Helix is a helix is a helix? (1997) (4)
Protein engineering strategies with potential applications for altering clinically relevant cellular pathways at the protein level (2016) (3)
Protein folding and design: from simple models to complex systems. (2008) (3)
'Morphs' (MRFs): metal-reversible folding domains for differential IgG binding. (2001) (3)
De Novo Design of Protein Structure and Function (1998) (3)
LIVE-PAINT: Super-Resolution Microscopy Inside Live Cells Using Reversible Peptide-Protein Interactions (2020) (3)
A step-by-step protocol for performing LIVE-PAINT super-resolution imaging of proteins in live cells using reversible peptide-protein interactions (2020) (3)
Intensification: A Resource for Amplifying Population-Genetic Signals with Protein Repeats. (2017) (2)
The molecular yo-yo method: live jump detection improves throughput of single-molecule force spectroscopy for out-of-equilibrium transitions. (2013) (2)
Engineering Metal Binding Sites in Proteins (1997) (2)
LIVE-PAINT Supplementary Videos (2020) (2)
Engineering and design. Recent adventures in molecular design. (1998) (2)
Rational design and self-assembly of coiled-coil linked SasG protein fibrils. (2020) (2)
Using physical features of protein core packing to distinguish real proteins from decoys (2020) (2)
A threonine zipper that mediates protein–protein interactions: Structure and prediction (2018) (2)
Designed TPR module (CTPR390) in complex with its peptide-ligand (Hsp90 peptide) (2010) (1)
Reengineering Granulocyte-Colony stimulating Factor (G-CSF) for Enhanced Stability (2001) (1)
Reply to: Comment on “Revisiting the Ramachandran plot from a new angle” (2011) (1)
Deconstructing protein structure (1991) (1)
Crystal structure of an 8 repeat consensus TPR superhelix (trigonal crystal form) (2006) (1)
The power of hard-sphere models for proteins: Understanding side-chain conformations and predicting thermodynamic stability (2013) (1)
What determines where a-helices begin and end ? (2005) (1)
Size polymorphism and the structure of aminoacyl-tRNA synthetases. (1984) (1)
Combining Design and Selection to Create Novel Protein-Peptide Interactions. (2016) (1)
The design of proteins with novel structures and activities (1996) (0)
The Ramachandran plot revisited from a new angle (2011) (0)
Characterization of Idealized Helical Repeat Proteins in Silicon Nitride Nanopores (2012) (0)
Computational Protein Redesign and Decoy Discrimination (2019) (0)
Self-Assembling Protein Surfaces for In Situ Capture of Cell-Free-Synthesized Proteins (2022) (0)
Molecular Dynamics Simulations of Consensus Tetratricopeptide Repeat Proteins (2010) (0)
Sterically allowed configuration space for amino acid dipeptides (2014) (0)
The power of simple hard-sphere models in protein structure prediction (2012) (0)
Protein goldendoodles: Designing new proteins (2014) (0)
Computational stability ranking of mutated hydrophobic cores in staphylococcal nuclease and T4 lysozyme using hard-sphere and stereochemical constraints (2014) (0)
Predicting side-chain conformations of methionine using a hard-sphere model with stereochemical constraints (2015) (0)
Understanding the native fluctuations of protein cores (2020) (0)
Editorial overview: Mechanistic biology: Dynamic interactions in biology - sensing change. (2015) (0)
The key differences in protein x-ray crystal and solution NMR structures (2020) (0)
Can understanding the packing of side chains improve the design of protein-protein interactions? (2011) (0)
Current MD forcefields fail to capture key features of protein structure and fluctuations: A case study of cyclophilin A and T4 lysozyme (2020) (0)
Folding and design of helical repeat proteins (2007) (0)
Paper alertPaper alert (1998) (0)
P3(2) CRYSTAL STRUCTURE OF ALA2ILE2-6, A VERSION OF ROP WITH A REPACKED HYDROPHOBIC CORE AND A NEW FOLD. (2001) (0)
Protein Engineering : N ew A pproaches and A pplications Protein Engineering : New Approaches and Applications (2013) (0)
Contributory presentations/posters (1999) (0)
Computational Studies of Protein-Protein Interface Designs (2016) (0)
Seeing inside the cell using live-paint: a new way to image proteins in living cells using superresolution microscopy (2022) (0)
Characterization of New and Improved Fluorescent Proteins and their Applications (2010) (0)
Signal Transduction by Designed Metal-Binding Proteins (2003) (0)
Direct Observation of the Time Evolution of a Biomolecular Transition (2014) (0)
Issue information (2018) (0)
Crystal Structure of the KH1-KH2 domains from human Fragile X Mental Retardation Protein (2007) (0)
Understanding the structural and mechanical properties of transmembrane proteins (2018) (0)
Core packing of well‐defined X‐ray and NMR structures is the same (2022) (0)
Percolation in protein cores: a novel approach to protein decoy detection (2019) (0)
Hard-Sphere Models for Predicting Side Chain Conformations of Proteins (2015) (0)
Correlations between Bond, Backbone, and Side Chain Dihedral Angles Enable Changes Among Different Dipeptide Configurations (2014) (0)
Uncovering diffusive states of the yeast proton pump, Pma1, and how labeling method can change diffusive behavior (2022) (0)
3.12 The Folding of Repeat Proteins (2012) (0)
Molecular Dynamics Simulations of Hydrophobic Residues (2013) (0)
Engineering and design 2001: A Design Odyssey Editorial overview (2001) (0)
Protein design. (1991) (0)
HIGH RESOLUTION STRUCTURE OF A HYPERSTABLE HELICAL BUNDLE PROTEIN MUTANT (1997) (0)
Interfacial complexation in microfluidic droplets for single-step fabrication of microcapsule (2017) (0)
Novel Computational Methods to Design Protein-Protein Interactions (2014) (0)
Solid-State Nanopore Translocation of Idealized Helical Repeat Proteins (2010) (0)
Integrated Graduate Program in Physical and Engineering Biology at Yale University (2014) (0)
1999 XIII International Biophysics Congress 19-24 September 1999 New Delhi Abstracts Suppl (2016) (0)
Void Distributions and Vibrational Response in Protein Cores (2018) (0)
The Effects of Histone Variant H2A.Z on Chromatin Structure and Kinetics-A Single Molecule Optical Tweezers Study (2014) (0)
NCBS SYMPOSIUM ON MOLECULES, MACHINES AND NETWORKS (2003) (0)
The latest in Engineering and design: the 2005 collection (2005) (0)
Small Angle X-ray Scattering Study of a Hard-Sphere Suspension : Concentrated Polystyrene Latex Spheres in Glycerol (2000) (0)
Steric clashes determine differences in side chain dihedral angle distributions: A study of Thr versus Val (2012) (0)
Computational Studies of Protein Core Mutations (2017) (0)
Structure of a Thr-rich interface in an Azami Green tetramer (2018) (0)
Studies of Voids in Proteins (2018) (0)
Crystal structure of E.coli TPR-protein NlpI (2004) (0)
Crystal structure of an 8 repeat consensus TPR superhelix (2005) (0)
Kinetics and Thermodynamics of Nucleosome Winding and Unwinding (2013) (0)
Understanding the Native Fluctuation of Protein Cores (2020) (0)
Crystal Structure of a Redesigned TPR Protein, T-MOD(VMY), in Complex with MEEVF Peptide (2009) (0)
Computational assessment of mutations of protein cores (2018) (0)
LIVE-PAINT Supplementary Videos: Compressed versions (2020) (0)
Computational modeling of the side chain dihedral angle distributions of methionine using hard-sphere repulsive and short-range attractive interactions (2016) (0)
Protein Engineering: New Approaches and Applications (2013) (0)
Structure of HOP TPR2A domain in complex with the non-cognate Hsc70 peptide ligand (2009) (0)
Crystal structure of an 8 repeat consensus TPR superhelix (orthorombic crystal form) (2008) (0)
Slower Infusion of Metoclopramide Reduces Akathisia (2007) (0)
Shining a light on the dark secrets of the cell: synthetic proteins for better fluorescence imaging (2019) (0)

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