Michael D. Waterfield

Michael D. Waterfield's AcademicInfluence.com Rankings

Biology

#5687

World Rank

#8226

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Cell Biology

#155

World Rank

#162

Historical Rank

Molecular Biology

#529

World Rank

#542

Historical Rank

Neuroscience

#658

World Rank

#686

Historical Rank

biology Degrees

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Biology

Michael D. Waterfield's Degrees

PhD Molecular Biology University of California, Berkeley

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Michael D. Waterfield's Published Works

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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells (1984) (2426)
Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences (1984) (2385)
Phosphatidylinositol-3-OH kinase direct target of Ras (1994) (2000)
Synthesis and function of 3-phosphorylated inositol lipids. (2001) (1668)
Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin (1985) (1523)
Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus (1983) (1466)
Sequence and expression of human estrogen receptor complementary DNA. (1986) (1341)
Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras (1997) (1127)
Cellular function of phosphoinositide 3-kinases: Implications for development, immunity, homeostasis, and cancer (2001) (1010)
Phosphoinositide 3-kinases: a conserved family of signal transducers. (1997) (1004)
Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice (2002) (997)
Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. (1986) (933)
Signaling by distinct classes of phosphoinositide 3-kinases. (1999) (928)
Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. (1993) (912)
Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system (1993) (751)
The complete primary structure of protein kinase C--the major phorbol ester receptor. (1986) (749)
Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. (2001) (728)
Signalling through phosphoinositide 3-kinases: the lipids take centre stage. (1999) (721)
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction (1996) (710)
Cloning of the human estrogen receptor cDNA. (1985) (702)
Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion. (1982) (688)
Phosphatidylinositol-3-OH kinases are Rab5 effectors (1999) (667)
Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit (1992) (632)
Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase (1991) (623)
Autophosphorylation sites on the epidermal growth factor receptor (1984) (621)
Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading. (1988) (620)
Activation of phosphoinositide 3‐kinase by interaction with Ras and by point mutation. (1996) (598)
Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase. (1996) (574)
Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor ceil (1988) (547)
The Drosophila phosphoinositide 3‐kinase Dp110 promotes cell growth. (1996) (509)
The GTPase dynamin binds to and is activated by a subset of SH3 domains (1993) (436)
Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor cell. (1988) (413)
Exploring the specificity of the PI3K family inhibitor LY294002. (2007) (409)
p110δ, a novel phosphoinositide 3-kinase in leukocytes (1997) (374)
Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases. (2007) (364)
A human phosphatidylinositol 3‐kinase complex related to the yeast Vps34p‐Vps15p protein sorting system. (1995) (361)
PI 3‐kinase: structural and functional analysis of intersubunit interactions. (1994) (341)
Cloning of the human oestrogen receptor cDNA. (1986) (316)
Expression of epidermal growth factor receptors on human cervical, ovarian, and vulval carcinomas. (1986) (311)
Cloning and DNA sequence of double-stranded copies of haemagglutinin genes from H2 and H3 strains elucidates antigenic shift and drift in human influenza virus (1980) (287)
Evaluation of Two-dimensional Differential Gel Electrophoresis for Proteomic Expression Analysis of a Model Breast Cancer Cell System* (2002) (284)
Regulation of imaginal disc cell size, cell number and organ size by Drosophila class IA phosphoinositide 3-kinase and its adaptor (1999) (279)
Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. (1997) (261)
Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages (1999) (259)
A novel point mutation in the tyrosine kinase domain of the RET proto-oncogene in sporadic medullary thyroid carcinoma and in a family with FMTC. (1995) (259)
A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding (2008) (258)
Purification of the fusion protein of Sendai virus: analysis of the NH2-terminal sequence generated during precursor activation. (1978) (257)
Studies on the primary structure of the influenza virus hemagglutinin. (1975) (249)
Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbb protein (1985) (247)
Using structure to define the function of phosphoinositide 3‐kinase family members (1997) (234)
Activation of Src family kinases by colony stimulating factor‐1, and their association with its receptor. (1993) (232)
Characterization of p150, an Adaptor Protein for the Human Phosphatidylinositol (PtdIns) 3-Kinase (1997) (228)
Purification to homogeneity of protein kinase C from bovine brain–identity with the phorbol ester receptor. (1984) (225)
P110delta, a novel phosphoinositide 3-kinase in leukocytes. (1997) (215)
Purification and characterization of vaccinia virus growth factor (1985) (213)
PI3-kinase inhibition: a target for drug development? (2000) (207)
The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein. (1995) (203)
Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity. (1985) (203)
Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties. (1999) (202)
Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid‐binding C2 domain (1997) (202)
Expression of the c‐erbB‐2 protein in normal and transformed cells (1987) (199)
Tyr721 regulates specific binding of the CSF‐1 receptor kinase insert to PI 3′‐kinase SH2 domains: a model for SH2‐mediated receptor‐target interactions. (1992) (196)
Purification and properties of porcine platelet‐derived growth factor. (1984) (195)
The CC Chemokine Monocyte Chemotactic Peptide-1 Activates both the Class I p85/p110 Phosphatidylinositol 3-Kinase and the Class II PI3K-C2α* (1998) (189)
A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor (1993) (182)
Expression of a platelet-derived growth factor-like protein in simian sarcoma virus transformed cells. (1983) (181)
Evaluation of epidermal growth factor receptors in bladder tumours. (1987) (171)
Class II Phosphoinositide 3-Kinases Are Downstream Targets of Activated Polypeptide Growth Factor Receptors (2000) (169)
Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110α inhibitors (2006) (167)
Activated phosphoinositide 3-kinase associates with membrane skeleton in thrombin-exposed platelets. (1992) (163)
Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach (1993) (156)
Epidermal growth factor receptors in lung tumours (1987) (153)
Platelet-derived growth factor elicits cyclic AMP accumulation in swiss 3T3 cells: Role of prostaglandin production (1983) (153)
The Class II Phosphoinositide 3-Kinase PI3K-C2α Is Concentrated in the Trans-Golgi Network and Present in Clathrin-coated Vesicles* (2000) (151)
An SH3 domain and proline-rich sequence mediate an interaction between two components of the phagocyte NADPH oxidase complex. (1994) (148)
Epidermal growth factor binding induces a conformational change in the external domain of its receptor. (1989) (146)
Solution structure and ligand-binding site of the SH3 domain of the p85α subunit of phosphatidylinositol 3-kinase (1993) (145)
Wiskott–Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases (1996) (144)
A monoclonal antibody to the human epidermal growth factor receptor (1982) (143)
Human Phosphoinositide 3-Kinase C2β, the Role of Calcium and the C2 Domain in Enzyme Activity* (1998) (143)
Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin. (2007) (141)
Molecular Cloning and Characterization of a Novel p70 S6 Kinase, p70 S6 Kinase β Containing a Proline-rich Region* (1998) (141)
On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors. (1987) (137)
A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction (1995) (136)
Structure of an SH2 domain of the p85α subunit of phosphatidylinositol-3-OH kinase (1994) (128)
Biosynthesis of the epidermal growth factor receptor in A431 cells. (1984) (127)
Primary structure of the human, membrane‐associated Ca2+‐binding protein p68 a novel member of a protein family. (1988) (125)
Crystal structure of the pleckstrin homology domain from dynamin (1994) (122)
Characterization of a phosphatidylinositol-specific phosphoinositide 3-kinase from mammalian cells (1994) (121)
The assembly of signalling complexes by receptor tyrosine kinases (1993) (117)
Synthesis and biological evaluation of pyrido[3′,2′:4,5]furo[3,2- d ]pyrimidine derivatives as novel PI3 kinase p110α inhibitors (2007) (115)
Interaction of the p85 subunit of PI 3‐kinase and its N‐terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes. (1992) (115)
Interaction of Shc with Adaptor Protein Adaptins (*) (1996) (114)
The human EGF receptor gene: structure of the 110 kb locus and identification of sequences regulating its transcription. (1987) (109)
Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110α inhibitors (2007) (107)
The urinary proteome in Fanconi syndrome implies specificity in the reabsorption of proteins by renal proximal tubule cells. (2004) (106)
Structure of the haemagglutinin of influenza virus. (1979) (106)
Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C. (1994) (106)
Evidence from studies with a cross-linking reagent that the haemagglutinin of influenza virus is a trimer. (1977) (105)
Active site and complete sequence of the suicidal methyltransferase that counters alkylation mutagenesis. (1985) (104)
T-cell cytotoxicity in the absence of viral protein synthesis in target cells (1977) (102)
Phosphatidylinositol 3-kinase: a novel effector. (1992) (99)
Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2 -a]pyridines as novel PI3 kinase p110α inhibitors (2007) (97)
Autophosphorylation of p110δ phosphoinositide 3‐kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo (1999) (97)
Tenascin: a modulator of cell growth. (1992) (96)
Proteomics--post-genomic cartography to understand gene function. (2001) (95)
Purification of multiple forms of glial growth factor. (1993) (95)
Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase. (1996) (94)
Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene. (1994) (93)
Three-dimensional solution structure of the pleckstrin homology domain from dynamin (1994) (91)
Antibodies to the autophosphorylation sites of the epidermal growth factor receptor protein‐tyrosine kinase as probes of structure and function. (1985) (87)
Phosphatidyl-inositol 3-kinase: a key enzyme in diverse signalling processes. (1992) (87)
Phosphoinositide 3-Kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms. (2006) (85)
Two distinct phosphoinositide 3‐kinases mediate polypeptide growth factor‐stimulated PKB activation (2002) (85)
Synaptojanin Is the Major Constitutively Active Phosphatidylinositol-3,4,5-trisphosphate 5-Phosphatase in Rodent Brain* (1997) (84)
Expression of the human EGF receptor with ligand‐stimulatable kinase activity in insect cells using a baculovirus vector. (1988) (83)
Activation Loop Sequences Confer Substrate Specificity to Phosphoinositide 3-Kinase α (PI3Kα) (2001) (82)
Large and small tumor antigens from simian virus 40 have identical amino termini mapping at 0.65 map units. (1978) (82)
Association of the p85 regulatory subunit of phosphatidylinositol 3-kinase with an essential erythropoietin receptor subdomain. (1993) (80)
Effects of ErbB-2 overexpression on mitogenic signalling and cell cycle progression in human breast luminal epithelial cells (2002) (77)
Influenza virus RNA segment 7 has the coding capacity for two polypeptides. (1980) (77)
Growth factor‐induced binding of dynamin to signal transduction proteins involves sorting to distinct and separate proline‐rich dynamin sequences. (1994) (77)
Growth factor receptors. (1989) (77)
Amplification and Overexpression of the EGF Receptor Gene in Primary Human Glioblastomas (1985) (74)
Divergent regulation of phosphatidylinositol 3-kinase P85 alpha and P85 beta isoforms upon T cell activation. (1993) (72)
A parallel proteomic and metabolomic analysis of the hydrogen peroxide‐ and Sty1p‐dependent stress response in Schizosaccharomyces pombe (2006) (72)
EPIDERMAL GROWTH FACTOR AND RELATED MOLECULES (1989) (71)
Purification and characterization of a phosphatidylinositol 3-kinase complex from bovine brain by using phosphopeptide affinity columns. (1992) (70)
Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck. (1996) (70)
Autophosphorylation promotes complex formation of recombinant hepatocyte growth factor receptor with cytoplasmic effectors containing SH2 domains. (1992) (69)
Structural and Membrane Binding Analysis of the Phox Homology Domain of Phosphoinositide 3-Kinase-C2α* (2006) (69)
Ras-independent and wortmannin-sensitive activation of glycogen synthase by insulin in Chinese hamster ovary cells (1995) (68)
The phosphorylation of eukaryotic ribosomal protein S6 by protein kinase C. (1985) (68)
Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system. (1992) (65)
Dynamic cofilin phosphorylation in the control of lamellipodial actin homeostasis (2007) (64)
Proteomic analysis of UVC irradiation‐induced damage of plasma proteins: Serum amyloid P component as a major target of photolysis (2006) (64)
Monoclonal antibodies against the human epidermal growth factor receptor from A431 cells. Isolation, characterization, and use in the purification of active epidermal growth factor receptor. (1984) (64)
Proteomic analysis of plasma membrane vesicles isolated from the rat renal cortex (2005) (63)
Structural basis for pleckstrin homology domain mutations in X-linked agammaglobulinemia. (1995) (62)
Metabolic studies on 1 2 5 I-labeled baby hamster kidney cell plasma membranes (1974) (61)
Recognition of viral glycoproteins by influenza A-specific cross- reactive cytolytic T lymphocytes (1980) (61)
Factors governing the solubilization of phosphopeptides retained on ferric NTA IMAC beads and their analysis by MALDI TOFMS (2002) (60)
Serum Peptide Profiling using MALDI Mass Spectrometry (2007) (60)
Quantification of Gel-separated Proteins and Their Phosphorylation Sites by LC-MS Using Unlabeled Internal Standards (2005) (59)
Accelerated high‐sensitivity microsequencing of proteins and peptides using a miniature reaction cartridge (1992) (59)
Erratum: Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor - (Current biology (1999) 9 (1019-1029)) (1999) (59)
Fusion of Sendai virus with the target cell membrane is required for T cell cytotoxicity (1978) (58)
The study of phosphoinositide 3-kinase function. (1996) (58)
Contributory effects of de novo transcription and premature transcript termination in the regulation of human epidermal growth factor receptor proto-oncogene RNA synthesis. (1991) (56)
Analysis of mammalian fibroblast transformation by normal and mutated human EGF receptors. (1989) (55)
Purification of Thy‐1‐related glycoproteins from human brain and fibroblasts: comparisons between these molecules and murine glycoproteins carrying Thy‐1.1 and Thy‐1.2 antigens (1981) (53)
Identification of a novel autophosphorylation site (P4) on the epidermal growth factor receptor. (1989) (52)
Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110alpha inhibitors. (2006) (52)
A novel neutrophil chemoattractant generated during an inflammatory reaction in the rabbit peritoneal cavity in vivo. Purification, partial amino acid sequence and structural relationship to interleukin 8. (1990) (50)
New insights into protein‐tyrosine kinase receptor signaling complexes (1993) (49)
The use of the amplifiable high-expression vector pEE14 to study the interactions of autoantibodies with recombinant human thyrotrophin receptor (1992) (49)
Regulation of human type II phosphatidylinositol kinase activity by epidermal growth factor-dependent phosphorylation and receptor association. (1994) (48)
Major Role of Epidermal Growth Factor Receptor and Src Kinases in Promoting Oxidative Stress-dependent Loss of Adhesion and Apoptosis in Epithelial Cells* (2009) (48)
A biosensor approach to probe the structure and function of the p85 alpha subunit of the phosphatidylinositol 3-kinase complex. (1993) (48)
Diverse functions (1991) (47)
Regulation of phosphoinositide kinases in T cells. Evidence that phosphatidylinositol 3-kinase is not a substrate for T cell antigen receptor-regulated tyrosine kinases. (1992) (47)
Differential Proteome Analysis of Replicative Senescence in Rat Embryo Fibroblasts*S (2002) (46)
Amino acid sequence analysis with methyl isothiocyanate. Resolution of the methylthiohydantoins by gas-liquid partition chromatography. (1970) (44)
Migration and Differentiation of Cerebral Cortical Neurons After Transplantation into the Brains of Ferrets (44)
mTORβ Splicing Isoform Promotes Cell Proliferation and Tumorigenesis* (2009) (44)
Solution structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase. (1998) (43)
AN IDIOTYPIC CROSS-REACTION BETWEEN ALLOTYPE a3 AND ALLOTYPE a NEGATIVE RABBIT ANTIBODIES TO STREPTOCOCCAL CARBOHYDRATE (1973) (43)
Conversion of a phosphoseryl/threonyl phosphatase into a phosphotyrosyl phosphatase. (1988) (43)
Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry. (2006) (42)
Cellular responses to ErbB-2 overexpression in human mammary luminal epithelial cells: comparison of mRNA and protein expression (2004) (42)
Normal activation of p70 S6 kinase by insulin in cells overexpressing dominant negative 85kD subunit of phosphoinositide 3-kinase. (1995) (42)
Structure and function of phosphatidylinositol 3-kinase: a potential second messenger system involved in growth control. (1993) (42)
Comparison of CD28‐B7.1 and B7.2 functional interaction in resting human T cells: Phosphatidylinositol 3‐kinase association to CD28 and cytokine production (1996) (42)
Binding to the Platelet-derived Growth Factor Receptor Transiently Activates the p85α-p110α Phosphoinositide 3-Kinase Complex in Vivo* (1996) (40)
The structure and function of the epidermal growth factor receptor studied by using antisynthetic peptide antibodies (1985) (40)
Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling. (2001) (40)
Purification and Biochemical Characterization of a Mammalian Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase (*) (1995) (39)
Alternative modes of binding of proteins with tandem SH2 domains (2008) (39)
p60 Is an Adaptor for the DrosophilaPhosphoinositide 3-Kinase, Dp110* (1997) (39)
Homology between the subunits of S100 and a 10kDa polypeptide associated with p36 of pig lymphocytes. (1986) (38)
Gene Targeting Attention to Detail (2004) (38)
Structural basis for epidermal growth factor receptor function. (1989) (38)
Beta1-integrin and PTEN control the phosphorylation of protein kinase C. (2000) (38)
Megakaryoblastic transformation of myelofibrosis with expression of the c-sis oncogene. (2009) (37)
Identification of a second neutrophil-chemoattractant cytokine generated during an inflammatory reaction in the rabbit peritoneal cavity in vivo. Purification, partial amino acid sequence and structural relationship to melanoma-growth-stimulatory activity. (1991) (37)
In vitro synthesis, glycosylation, and membrane insertion of influenza virus haemagglutinin. (1979) (36)
Molecular cloning and biochemical characterization of a Drosophila phosphatidylinositol-specific phosphoinositide 3-kinase. (1997) (35)
Binding of a Diphosphotyrosine-containing Peptide That Mimics Activated Platelet-derived Growth Factor Receptor β Induces Oligomerization of Phosphatidylinositol 3-Kinase* (1998) (35)
Ionic responses rapidly elicited by porcine platelet‐derived growth factor in Swiss 3T3 cells. (1984) (35)
Nonhistone virion proteins of polyoma: characterisation of the particle proteins by tryptic peptide analysis by use of ion-exchange columns. (1975) (34)
Solution structure and ligand-binding site of the SH3 domain of the p85 alpha subunit of phosphatidylinositol 3-kinase. (1993) (34)
Ruk is ubiquitinated but not degraded by the proteasome. (2002) (33)
Purification and partial amino acid sequence analysis of the cellular tumour antigen, p53, from mouse SV40‐transformed cells. (1983) (33)
Anti epidermal growth factor receptor monoclonal antibodies (1983) (32)
A radioimmunoassay for human epidermal growth factor receptor. (1984) (31)
Enhanced phosphopeptide isolation by Fe(III)‐IMAC using 1,1,1,3,3,3‐hexafluoroisopropanol (2005) (31)
Targeted Expression of the Class II Phosphoinositide 3-Kinase in Drosophila melanogaster Reveals Lipid Kinase-Dependent Effects on Patterning and Interactions with Receptor Signaling Pathways (2004) (31)
Variation in the primary structure of antibodies during the course of immunization. (1971) (31)
Biochemical characterization of the free catalytic p110 alpha and the complexed heterodimeric p110 alpha.p85 alpha forms of the mammalian phosphatidylinositol 3-kinase. (1994) (31)
Serum Proteomic Abnormality Predating Screen Detection of Ovarian Cancer (2009) (30)
The catalytic subunit of phosphatidylinositol 3-kinase is a substrate for the activated platelet-derived growth factor receptor, but not for middle-T antigen-pp60c-src complexes. (1994) (30)
Phosphopeptide binding to the N‐terminal SH2 domain of the p85α subunit of PI 3′‐kinase: A heteronuclear NMR study (1994) (29)
Rabbit immunoglobulin light chains: correlation of variable region sequences with allotypic markers. (1973) (29)
Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase. (1992) (27)
a novel phosphoinositide 3-kinase in leukocytes (1997) (27)
The crystal structure of the N-terminal SH3 domain of Grb2. (1995) (26)
Purification and characterization of phosphatidylinositol 4-kinase from human erythrocyte membranes. (1991) (25)
Structural similarity between the pleckstrin homology domain and verotoxin: The problem of measuring and evaluating structural similarity (1995) (24)
Influenza virus haemagglutinin signal sequence (1979) (24)
Characterization of the bovine brain cytosolic phosphatidylinositol 3-kinase complex. (1993) (24)
Highly purified fibroblast‐derived growth factor, an SV40‐transformed fibroblast‐secreted mitogen, is closely related to platelet‐derived growth factor. (1985) (24)
Identification of novel candidates for replicative senescence by functional proteomics (2002) (24)
Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors. (2007) (24)
Riding the evanescent wave (1993) (23)
Isolation and characterization of structurally homogeneous antibodies from antipneumococcal sera. (1970) (22)
Antibodies to the ATP-binding site of the human epidermal growth factor (EGF) receptor as specific inhibitors of EGF-stimulated protein-tyrosine kinase activity. (1986) (22)
Structural analysis of PI3-kinase isoforms: identification of residues enabling selective inhibition by small molecule ATP-competitive inhibitors. (2008) (22)
Stress‐induced changes in the Schizosaccharomyces pombe proteome using two‐dimensional difference gel electrophoresis, mass spectrometry and a novel integrated robotics platform (2005) (22)
Disulphide bonds of haemagglutinin of Asian influenza virus (1981) (21)
Restricted structural heterogeneity in antibodies: might different heavy chains have a common light chain? (1972) (20)
The SH3 and BH domains of the p85alpha adapter subunit play a critical role in regulating class Ia phosphoinositide 3-kinase function. (1999) (20)
Protein kinases in cellular signal transduction: tyrosine kinase growth factor receptors and protein kinase C. (1986) (19)
Structural and Biochemical Evaluation of the Interaction of the Phosphatidylinositol 3-Kinase p85α Src Homology 2 Domains with Phosphoinositides and Inositol Polyphosphates* (1999) (19)
Conformal predictors in early diagnostics of ovarian and breast cancers (2012) (19)
Modulation of the substrate specificity of the mammalian phosphatidylinositol 3-kinase by cholesterol sulfate and sulfatide. (1995) (19)
Effect of 1,4-dihydro-3,5-dicarbethoxycollidine on hepatic microsomal haem, cytochrome b5 and cytochrome P450 in rabbits and mice. (1969) (18)
Mammalian phosphatidylinositol 3'-kinase induces a lethal phenotype on expression in Schizosaccharomyces pombe; comparison with the VPS34 gene product. (1994) (17)
Synthesis and biological evaluation of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110alpha inhibitors. (2007) (17)
Immunological and chemical purity of papain-solubilized HL-A antigens. (1975) (16)
Republication: Targeting PI3KC2β Impairs Proliferation and Survival in Acute Leukemia, Brain Tumours and Neuroendocrine Tumours (2012) (16)
Electron‐microscopic changes in the livers of mice treated with the porphyrinogenic agent 1,4‐dihydro‐3,5‐dicarbethoxycollidine (1969) (16)
Proteomic response of Schizosaccharomyces pombe to static and oscillating extremely low‐frequency electromagnetic fields (2006) (16)
Correlation between genetic loci and structural differences in the capsid proteins of polyoma virus plaque morphology mutants (1977) (15)
Prediction and analysis of SH2 domain-phosphopeptide interactions. (1995) (14)
Altered growth regulation in cancer. (1989) (14)
Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta. (1992) (14)
Multiprobabilistic prediction in early medical diagnoses (2015) (13)
Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110alpha inhibitors. (2007) (13)
Proteolytic generation of constitutive tyrosine kinase activity of the human insulin receptor. (1989) (12)
The expression of multiple forms of troponin T in chicken-fast-skeletal muscle may result from differential splicing of a single gene. (1984) (12)
Structure of human epidermal growth factor receptor and expression of normal and variant mRNAs in epidermoid carcinoma cells (1985) (11)
Gas-liquid chromatography of radioactive amino acids as their trifluoroacetyl ester derivatives. (1969) (11)
Multiprobabilistic Venn Predictors with Logistic Regression (2012) (10)
A protein sequencing device of simple construction. (1970) (10)
Partial amino-terminal sequences of the polyoma nonhistone proteins VP1, VP2, and VP3 synthesized in vitro (1980) (10)
β 1-Integrin and PTEN control the phosphorylation of protein kinase C (9)
Expression of epidermal-growth-factor receptor in the K562 cell line by transfection. Altered receptor biochemistry. (1990) (9)
The C-terminal SH3 domain of p67phox binds its natural ligand in a reverse orientation. (1996) (9)
Metabolic studies on 125I-labeled baby hamster kidney cell plasma membranes. (1974) (9)
Receptor signalling: To Sevenless, a daughter (1996) (8)
Polyoma virus complementary RNA directs the in vitro synthesis of capsid proteins VP1 and VP2 (1978) (8)
Identification of novel candidates for replicative senescence by functional proteomics (2002) (8)
The isolation and characterisation of cDNA and genomic clones for human lecithin: cholesterol acyltransferase. (1987) (7)
Structural Studies of the Hemagglutinin of the Asian Influenza Virus Japan/305/57 — Bellamy/42 (H2N1).Cyanogen Bromide Cleavage of the Larger Polypeptide Chain HA1 (1978) (7)
Structural and functional features of a cell surface phosphoglycoprotein associated with tumorigenic phenotype in human fibroblast x HeLa cell hybrids. (1986) (7)
Functional and regulatory properties of p70s6 kinase β (1999) (7)
Cell surface receptors for polypeptide hormones, growth factors and neuropeptides. (1989) (7)
414A Pharmacological properties and in vitro and in vivo antitumour activity of the potent and selective PI3 kinase inhibitor PI103 (2004) (7)
Expression and properties of epidermal growth factor receptor expressed from baculovirus vectors. (1991) (7)
Studies on the structure of the haemagglutinin. (1980) (7)
Purification of N-trifluoroacetyl amino acid n-butyl esters for analysis by gas chromatography. (1969) (6)
Comparative analysis of the regions binding beta gamma-subunits in Galpha and PH domains. (1996) (6)
Purification of the fusion protein of Sendai virus : Analysis of the NH 2-terminal sequence generated during precursor activation ( activation of infectivity / influenza hemagglutinin / hydrophobic amino terminus ) (4)
CLRC—TR—08—02 Analysis of serial UKCTOCS-OC data: discriminating abilities of proteomics peaks (2008) (4)
Isolation of a polymorphic genomic clone from chromosome 7 (1987) (4)
The Purification and Structural Characterization of the Fusion Factor of Sendai Virus (1978) (3)
Inactivation of PRIM 1 Function Sensitizes Cancer Cells to ATR and CHK 1 Inhibitors 1 (2003) (3)
A heteronuclear NMR study (2002) (3)
The Structure of the Small Polypeptide Chain of the Hemagglutinin of an Asian Influenza Virus Japan 305/57 — Bellamy/42 (H2N1) (1978) (3)
Purification and characterization of placental membrane phosphotyrosine phosphatases. (1988) (3)
Functional Proteomic Analysis of Long-term Growth Factor Stimulation and Receptor Tyrosine Kinase Coactivation in Swiss 3T3 Fibroblasts* (2012) (2)
Intermolecular Interactions of the p85a Regulatory Subunit of Phosphatidylinositol 3-Kinase* (1999) (2)
BglII polymorphism of the epidermal growth factor receptor (EGF-R) gene. (1988) (2)
The Use of Anti-Synthetic Peptide Antibodies to Study the v-erb B Protein from Chicken and Rat Cells Transformed by Avian Erythroblastosis Virus (1985) (2)
Synthetic peptide approach to the analysis of kinase activities of avian EGF receptor and v-erbB protein. (1985) (2)
Two distinct mechanisms involving growth factors employed in subversion of growth regulation by oncogenes. (1985) (2)
Evaluation ofepidermal growth factor receptors inbladder tumours (1987) (2)
Some recent studies of intermediary metabolism in experimental porphyria. (1966) (1)
Ligand- and Antibody-Affinity Purification of the Epidermal Growth Factor Receptor (1990) (1)
Altered expression of epidermal growth factor receptors in human bladder and lung tumours. (1986) (1)
SECONDARY SENDAI-SPECIFIC T-EFFECTOR CELLS: REQUIREMENTS FOR RESTIMULATION, TARGET CELLS RECOGNITION, AND LYSIS (1979) (1)
YAC clone H10 discriminates between 3q26.2 and 3q27 chromosome rearrangements in hematological disorders. (1996) (1)
Subversion of growth factor signal transduction by oncogenes (1985) (1)
Structural and Membrane Binding Analysis of the PX Domain of Phosphoinositide 3-Kinase-C2α * (2006) (1)
Experimental Medicine Edited by R Recognition of Viral Glycoproteins by Influenza Α-specific Cross-reactive Cytolytic Τ Lymphocytes* Materials and Methods (0)
Table of Contents (1984) (0)
The Structure and Function of Growth Factor Receptors and Their Subversion in Cancer (1990) (0)
Glialmitogene factors as well as their preparation and use (1992) (0)
SOLUTION STRUCTURE OF THE C-TERMINAL SH2 DOMAIN OF THE P85ALPHA REGULATORY SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE, NMR, 30 STRUCTURES (1998) (0)
Growth factors in cell and developmental biology : proceedings of the British Society for Cell Biology -- Journal of Cell Science Symposium, Manchester, April 1990 (1990) (0)
[4] Purification of fibroblast-derived growth factor (1987) (0)
Immunological and Chemical Purity of Papain-Solubilized HLA Antigens ( radiolabeling / immune complexes / gel filtration / N-terminal amino acids ) (0)
Expression of functional EGF receptors in insect cells using a baculovirus vector (1987) (0)
Parallel 2D-DIGE and microarray expression profiling of a model breast cancer cell system (2002) (0)
SOLUTION STRUCTURE OF THE C-TERMINAL SH2 DOMAIN OF THE P85ALPHA REGULATORY SUBUNIT OF PHOSPHOINOSITIDE 3-KINASE, NMR, MINIMIZED AVERAGE STRUCTURE (1998) (0)
Improvements to growth factors. (1985) (0)
Studies on the Structure and Activities of Influenza Virus Haemagglutinin (1984) (0)
Polypeptides which inhibit the NADPH oxidase complex (1994) (0)
Table of Contents (1994) (0)
Analysis of ErbB-2 overexpression in breast cancer using functional proteomics and genomics (2003) (0)
The use of optical techniques to detect conformational changes associated with the interaction of epidermal growth factor and its receptor. (1990) (0)
Structure-Function Studies of Growth-Factor Receptors (1987) (0)
The p110 delta isoform of phosphatidylinositol 3-kinase associates with the T lymphocyte costimulatory molecule CD28. (1998) (0)
A robust and sensitive automated method for MS-based serum pattern diagnostics using well-established ZipTip technology and ultrafiltration (2008) (0)
The Use of the Automatic Edman Sequenator in the Structural Analysis of Polypeptides (1974) (0)
Glialmitogene factors, their production and use (1992) (0)
NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE KINASE COMPLEXED WITH THE SYNTHETIC PEPTIDE P2L CORRESPONDING TO RESIDUES 91-104 OF THE P85 SUBUNIT OF PI3-KINASE, MINIMIZED AVERAGE (PROBMAP) STRUCTURE (1998) (0)
Comparative Analysis of the Regions Binding bg-Subunits in G a and PH Domains (1996) (0)
Studies with Anti-Pneumococcal Antibodies (1971) (0)
SH2 Domains of the p85cx Subunit of Phosphatidylinositol 3-Kinase Regulate Binding to Growth Factor Receptors (0)
Purification of fibroblast-derived growth factor. (1987) (0)
Conformal Predictors in Risk Assessment of Ovarian and Breast Cancers (2012) (0)
Variable Region Sequence Differences Associated with Rabbit Light Chain Allotypes (1971) (0)
Table of Contents (1992) (0)
NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE COMPLEXED WITH THE SYNTHETIC PEPTIDE P2L CORRESPONDING TO RESIDUES 91-104 OF THE P85 SUBUNIT OF PI3-KINASE, FAMILY OF 25 STRUCTURES (1998) (0)
MOLECULAR APPROACHES TO UNDERSTANDING EGF-RECEPTOR STRUCTURE - FUNCTION RELATIONSHIPS (1987) (0)
Table of Contents (1988) (0)
Republication: Targeting PI3KC2β Impairs Proliferation and Survival in Acute Leukemia, Brain Tumours and Neuroendocrine Tumours. (2022) (0)
Phosphoproteomic analysis of oxidative stress in mammary epithelial cells: Major role of Src kinase-dependent phosphorylation in regulating adhesion (2010) (0)
Kinetic data reliability. (1997) (0)
Multi-enzyme complexes associated with receptors during signal transduction. (1992) (0)
ANALYSIS OF REQUIREMENTS FOR CELL MEDIATED LYSIS INTERACTION BETWEEN VIRAL GLYCOPROTEINS AND CELL PLASMA MEMBRANES (1979) (0)
Interaction ofthep85subunit ofPi3-kinase andits N-terminal SH2domainwitha PDGFreceptor phosphorylation site: structural features andanalysis of conformational changes (1992) (0)

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