M. Daniel Lane

Q: What Schools Are Affiliated With M. Daniel Lane

M. Daniel Lane is affiliated with the following schools: University of Alabama at Birmingham, Ibaraki University, University of Southern Denmark, University of California, Berkeley, Iowa State University, Stanford University, Johns Hopkins University

M. Daniel Lane's AcademicInfluence.com Rankings

M. Daniel Lane

Biology

#3616

World Rank

#5498

Historical Rank

#1450

USA Rank

Biochemistry

#416

World Rank

#495

Historical Rank

#157

USA Rank

biology Degrees

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Biology

M. Daniel Lane's Degrees

PhD Biochemistry University of California, Berkeley
Bachelors Chemistry Stanford University

Why Is M. Daniel Lane Influential?

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According to Wikipedia, Malcolm Daniel Lane was a biochemist who spent most of his career on the faculty at the Johns Hopkins School of Medicine in Baltimore, Maryland. Lane served as the head of the Department of Biological Chemistry from 1978 to 1997, was elected to the National Academy of Sciences in 1987, and was named a University Distinguished Service Professor – the institution's highest academic title – in 2001. Lane's research focused on the biochemistry of lipids and lipid metabolism, and the resulting physiological mechanisms regulating adipogenesis and obesity.

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M. Daniel Lane's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Leptin regulates proinflammatory immune responses. (1998) (1247)
Transcriptional regulation of gene expression during adipocyte differentiation. (1995) (1084)
Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. (2000) (948)
Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. (1997) (816)
Mitotic clonal expansion: A synchronous process required for adipogenesis (2002) (770)
Adipogenesis: from stem cell to adipocyte. (2012) (669)
Regulation of adipocyte development. (1994) (659)
Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes. (1980) (559)
Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes. (1989) (550)
Adipose Development: From Stem Cell to Adipocyte (2005) (541)
Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. (1995) (531)
CCAAT/enhancer-binding protein β is required for mitotic clonal expansion during adipogenesis (2003) (468)
Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes (2002) (460)
Evidence for the involvement of vicinal sulfhydryl groups in insulin-activated hexose transport by 3T3-L1 adipocytes. (1985) (451)
CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program. (1994) (440)
Obesity Induces Expression of Uncoupling Protein-2 in Hepatocytes and Promotes Liver ATP Depletion* (1999) (426)
Activation and centromeric localization of CCAAT/enhancer-binding proteins during the mitotic clonal expansion of adipocyte differentiation. (1999) (392)
Commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. (2004) (372)
CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes. (1991) (364)
Differentiation-induced gene expression in 3T3-L1 preadipocytes. Characterization of a differentially expressed gene encoding stearoyl-CoA desaturase. (1988) (329)
BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage (2009) (320)
Spinach ribulose diphosphate carboxylase. I. Purification and properties of the enzyme. (1966) (320)
A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity. (1993) (313)
Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes. (1992) (312)
Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase. (1989) (310)
Sequential phosphorylation of CCAAT enhancer-binding protein β by MAPK and glycogen synthase kinase 3β is required for adipogenesis (2005) (302)
Role of the CCAAT enhancer binding proteins (C/EBPs) in adipocyte differentiation. (1999) (281)
Encyclopedia of biological chemistry (2004) (279)
Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes. (1989) (275)
Expression of specific mRNAs during adipose differentiation: identification of an mRNA encoding a homologue of myelin P2 protein. (1984) (270)
Role of CREB in Transcriptional Regulation of CCAAT/Enhancer-binding Protein β Gene during Adipogenesis* (2004) (267)
Hypothalamic malonyl-CoA as a mediator of feeding behavior (2003) (261)
Evidence for an increase in transcription of specific mRNAs during differentiation of 3T3-L1 preadipocytes. (1985) (261)
Regulating Adipogenesis* (1997) (260)
The enzymatic carboxylation of phosphoenolpyruvate. II. Purification and properties of liver mitochondrial phosphoenolpyruvate carboxykinase. (1966) (259)
Mouse insulin-responsive glucose transporter gene: characterization of the gene and trans-activation by the CCAAT/enhancer binding protein. (1990) (255)
Adipocyte differentiation and leptin expression. (1997) (254)
Is CCAAT/enhancer-binding protein a central regulator of energy metabolism? (1989) (244)
The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis. (2006) (243)
Induction of lipogenesis during differentiation in a "preadipocyte" cell line. (1976) (237)
Suppression of Preadipocyte Differentiation and Promotion of Adipocyte Death by HIV Protease Inhibitors* (2000) (231)
Lipoprotein lipase suppression in 3T3-L1 cells by an endotoxin-induced mediator from exudate cells. (1982) (230)
Liver acetyl CoA carboxylase and fatty acid synthetase: relative activities in the normal state and in hereditary obesity. (1967) (230)
Stable stem cell commitment to the adipocyte lineage by inhibition of DNA methylation: Role of the BMP-4 gene (2006) (212)
Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity. (2009) (210)
Convergence of Peroxisome Proliferator-activated Receptor γ and Foxo1 Signaling Pathways* (2003) (205)
Transcriptional activation of the mouse obese (ob) gene by CCAAT/enhancer binding protein alpha. (1996) (201)
Mitotic Clonal Expansion during Preadipocyte Differentiation: Calpain-mediated Turnover of p27* (2000) (196)
Acetyl coenzyme A carboxylase. (1974) (196)
Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides (2001) (194)
The biotin-dependent enzymes. (1971) (187)
Differential effects of central fructose and glucose on hypothalamic malonyl–CoA and food intake (2008) (181)
Brain fatty acid synthase activates PPARα to maintain energy homeostasis (2007) (179)
Role of C/EBP homologous protein (CHOP-10) in the programmed activation of CCAAT/enhancer-binding protein-beta during adipogenesis. (2000) (176)
Dominant-negative C/EBP disrupts mitotic clonal expansion and differentiation of 3T3-L1 preadipocytes (2003) (173)
Intracellular localization of the 3-hydroxy-3-methylglutaryl coenzme A cycle enzymes in liver. Separate cytoplasmic and mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A generating systems for cholesterogenesis and ketogenesis. (1975) (173)
Sequential phosphorylation of CCAAT enhancer-binding protein beta by MAPK and glycogen synthase kinase 3beta is required for adipogenesis. (2005) (173)
Insulin receptor synthesis and turnover in differentiating 3T3-L1 preadipocytes. (1981) (171)
Acetyl coenzyme A carboxylase system of Escherichia coli. Purification and properties of the biotin carboxylase, carboxyltransferase, and carboxyl carrier protein components. (1974) (169)
Effect of tunicamycin on the secretion of serum proteins by primary cultures of rat and chick hepatocytes. Studies on transferrin, very low density lipoprotein, and serum albumin. (1978) (150)
Regulation of the O-Linked β-N-Acetylglucosamine Transferase by Insulin Signaling* (2008) (149)
Regulation of Insulin Receptor Substrate 1 (IRS-1)/AKT Kinase-mediated Insulin Signaling by O-Linked β-N-Acetylglucosamine in 3T3-L1 Adipocytes* (2009) (149)
Insulin Regulates Transcription of the CCAAT/Enhancer Binding Protein (C/EBP) , , and Genes in Fully-differentiated 3T3-L1 Adipocytes (*) (1995) (149)
Synthesis, turnover, and down-regulation of epidermal growth factor receptors in human A431 epidermoid carcinoma cells and skin fibroblasts. (1982) (148)
Repressive Effect of Sp1 on the C/EBPα Gene Promoter: Role in Adipocyte Differentiation (1999) (147)
Nonidentical subunits of ribulose diphosphate carboxylase. (1967) (146)
On the mechanism of ligand-induced down-regulation of insulin receptor level in the liver cell. (1981) (145)
Role of glycosylation in the processing of newly translated insulin proreceptor in 3T3-L1 adipocytes. (1984) (145)
Differential effects of a centrally acting fatty acid synthase inhibitor in lean and obese mice (2002) (143)
Obese gene expression at in vivo levels by fat pads derived from s.c. implanted 3T3-F442A preadipocytes. (1997) (142)
Temporal profiling of the adipocyte proteome during differentiation using a five-plex SILAC based strategy. (2009) (141)
The enzymatic carboxylation of phosphoenolpyruvate. I. Purification and properties of phosphoenolpyruvate carboxylase. (1966) (138)
Glucocorticoids reciprocally regulate expression of the CCAAT/enhancer-binding protein alpha and delta genes in 3T3-L1 adipocytes and white adipose tissue. (1994) (135)
A Role for Bone Morphogenetic Protein-4 in Adipocyte Development (2007) (135)
Selective inhibition of synthesis of enzymes for de novo fatty acid biosynthesis by an endotoxin-induced mediator from exudate cells. (1983) (132)
A Role for Hypothalamic Malonyl-CoA in the Control of Food Intake* (2005) (130)
[53] Ribulose diphosphate carboxylase from spinach leaves (1971) (127)
Transcriptional control of the stearoyl-CoA desaturase-1 gene by polyunsaturated fatty acids. (1994) (125)
Electric pulse-induced fusion of 3T3 cells in monolayer culture. (1982) (123)
Convergence of peroxisome proliferator-activated receptor gamma and Foxo1 signaling pathways. (2003) (122)
High fat diet-induced hyperglycemia: prevention by low level expression of a glucose transporter (GLUT4) minigene in transgenic mice. (1995) (122)
Promoter-cDNA-directed heterologous protein expression in Xenopus laevis oocytes. (1992) (121)
Regulation of hypothalamic malonyl-CoA by central glucose and leptin (2007) (119)
Synthesis of epidermal growth factor receptor in human A431 cells. Glycosylation-dependent acquisition of ligand binding activity occurs post-translationally in the endoplasmic reticulum. (1986) (119)
Insulin-activated tyrosine phosphorylation of a 15-kilodalton protein in intact 3T3-L1 adipocytes. (1987) (119)
Liver acetyl coenzyme A carboxylase. I. Isolation and cat- alytic properties. (1968) (116)
Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis. (2007) (115)
Insulin down-regulates expression of the insulin-responsive glucose transporter (GLUT4) gene: effects on transcription and mRNA turnover. (1993) (114)
Selective changes in microsomal enzymes of triacylglycerol phosphatidylcholine, and phosphatidylethanolamine biosynthesis during differentiation of 3T3-L1 preadipocytes. (1978) (114)
Tumor Necrosis Factor α Promotes Nuclear Localization of Cytokine-inducible CCAAT/Enhancer Binding Protein Isoforms in Hepatocytes* (1996) (114)
Alterations in insulin binding accompanying differentiation of 3T3-L1 preadipocytes. (1977) (113)
Lipogenesis and the synthesis and secretion of very low density lipoprotein by avian liver cells in nonproliferating monolayer culture. Hormonal effects (1977) (113)
A mild procedure for the rapid release of cytoplasmic enzymes from cultured animal cells. (1979) (109)
Rapid, reversible internalization of cell surface insulin receptors. Correlation with insulin-induced down-regulation. (1983) (108)
Role of calpain in adipocyte differentiation. (1999) (105)
The Role of Hypothalamic Malonyl-CoA in Energy Homeostasis* (2006) (103)
Inhibition of hypothalamic fatty acid synthase triggers rapid activation of fatty acid oxidation in skeletal muscle. (2005) (100)
THE ENZYMATIC SYNTHESIS OF HOLOTRANSCARBOXYLASE FROM APOTRANSCARBOXYLASE AND (+)-BIOTIN. II. INVESTIGATION OF THE REACTION MECHANISM. (1964) (99)
Bacterial lipopolysaccharide induces uncoupling protein-2 expression in hepatocytes by a tumor necrosis factor-alpha-dependent mechanism. (1998) (99)
Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem (2003) (97)
Role of cdk2 in the sequential phosphorylation/activation of C/EBPβ during adipocyte differentiation (2007) (97)
Cross-talk between sympathetic neurons and adipocytes in coculture (2001) (95)
Post-translational processing of the epidermal growth factor receptor. Glycosylation-dependent acquisition of ligand-binding capacity. (1985) (95)
Substrate phosphorylation catalyzed by the insulin receptor tyrosine kinase. Kinetic correlation to autophosphorylation of specific sites in the beta subunit. (1989) (95)
Insulin-induced down-regulation of insulin receptors in 3T3-L1 adipocytes. Altered rate of receptor inactivation. (1982) (94)
Molecular and catalytic properties of cytosolic acetoacetyl coenzyme A thiolase from avian liver. (1973) (94)
Acetyl coenzyme A carboxylase system of Escherichia coli. Studies on the mechanisms of the biotin carboxylase- and carboxyltransferase-catalyzed reactions. (1974) (93)
Effect of vanadate on the cellular accumulation of pp15, an apparent product of insulin receptor tyrosine kinase action. (1988) (91)
Tissue specific expression of p422 protein, a putative lipid carrier, in mouse adipocytes. (1985) (90)
Iodophenylarsine oxide and arsenical affinity chromatography: new probes for dithiol proteins. Application to tubulins and to components of the insulin receptor-glucose transporter signal transduction pathway. (1992) (89)
Lytic replication-associated protein (RAP) encoded by Kaposi sarcoma-associated herpesvirus causes p21CIP-1-mediated G1 cell cycle arrest through CCAAT/enhancer-binding protein-α (2002) (89)
Sequential gene promoter interactions by C/EBPβ, C/EBPα, and PPARγ during adipogenesis (2004) (89)
Molecular characteristics of liver acetyl CoA carboxylase. (1966) (88)
Brain‐specific carnitine palmitoyl‐transferase‐1c: role in CNS fatty acid metabolism, food intake, and body weight (2008) (85)
Expression of the differentiation-induced gene for fatty acid-binding protein is activated by glucocorticoid and cAMP. (1988) (85)
Effect of phosphorylation and S–S bond-induced dimerization on DNA binding and transcriptional activation by C/EBPβ (2007) (85)
Modulating the transcriptional control of adipogenesis. (1997) (84)
Monitoring energy balance: metabolites of fatty acid synthesis as hypothalamic sensors. (2005) (82)
Wnt signaling and adipocyte lineage commitment (2008) (81)
Regulation of food intake and energy expenditure by hypothalamic malonyl-CoA (2008) (81)
The Transcription Factor Nuclear Factor I Mediates Repression of the GLUT4 Promoter by Insulin* (1999) (81)
Transcriptional repression of the mouse insulin-responsive glucose transporter (GLUT4) gene by cAMP. (1991) (81)
Post-translational changes in tertiary and quaternary structure of the insulin proreceptor. Correlation with acquisition of function. (1988) (80)
Acetyl coenzyme A carboxylase system of Escherichia coli. Site of carboxylation of biotin and enzymatic reactivity of 1'-N-(ureido)-carboxybiotin derivatives. (1974) (80)
The interaction of metal ions with ribulose 1,5-diphosphate carboxylase from spinach. (1970) (79)
Post-translational glycosylation-induced activation of aglycoinsulin receptor accumulated during tunicamycin treatment. (1981) (79)
Control of energy homeostasis: role of enzymes and intermediates of fatty acid metabolism in the central nervous system. (2006) (78)
Formation and turnover of triglyceride-rich vesicles in the chick liver cell. Effects of cAMP and carnitine on triglyceride mobilization and conversion to ketones. (1981) (76)
Studies on the function of vitamin A in metabolism. (1957) (76)
Effect of glucose and fructose on food intake via malonyl-CoA signaling in the brain. (2009) (75)
Stringent control of fatty acid synthesis in Escherichia coli. Possible regulation of acetyl coenzyme A carboxylase by ppGpp. (1973) (74)
Up-regulation of uncoupling protein-3 by fatty acid in C2C12 myotubes. (1999) (74)
Liver acetyl coenzyme A carboxylase. II. Further molecular characterization. (1968) (74)
Derepression of the C/EBPα gene during adipogenesis: Identification of AP-2α as a repressor (1998) (74)
Control of insulin receptor level in 3T3 cells: effect of insulin-induced down-regulation and dexamethasone-induced up-regulation on rate of receptor inactivation. (1982) (73)
Acetyl Coenzyme A Carboxylase: Filamentous Nature of the Animal Enzymes (1969) (72)
Inhibition of ribulose diphosphate carboxylase by cyanide. Inactive ternary complex of enzyme, ribulose diphosphate, and cyanide. (1969) (72)
Mechanism of regulation of the 422(aP2) gene by cAMP during preadipocyte differentiation. (1989) (71)
Studies of insulin resistance in adipocytes induced by macrophage mediator (1983) (70)
Role of pyruvate carboxylase in fatty acid synthesis: alterations during preadipocyte differentiation. (1977) (70)
Acetyl-CoA carboxylase. Evidence for polymeric filament to protomer transition in the intact avian liver cell. (1978) (68)
THE ENZYMATIC SYNTHESIS OF HOLOTRANSCARBOXYLASE FROM APOTRANSCARBOXYLASE AND (+)-BIOTIN. I. PURIFICATION OF THE APOENZYME AND SYNTHETASE; CHARACTERISTICS OF THE REACTION. (1964) (68)
Down-regulation of epidermal growth factor receptor correlates with plasminogen activator activity in human A431 epidermoid carcinoma cells. (1983) (67)
Molecular and catalytic properties of mitochondrial (ketogenic) 3-hydroxy-3-methylglutaryl coenzyme A synthase of liver. (1975) (67)
Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1α (2006) (67)
From multipotent stem cell to adipocyte. (2005) (65)
Role of glycosylation and protein synthesis in insulin receptor metabolism by 3T3-L1 mouse adipocytes. (1981) (63)
Commitment of C 3 H 10 T 1 2 pluripotent stem cells to the adipocyte lineage (2004) (63)
Effect of phenylarsine oxide on insulin-dependent protein phosphorylation and glucose transport in 3T3-L1 adipocytes. (1987) (63)
Phosphotyrosyl turnover in insulin signaling. Characterization of two membrane-bound pp15 protein tyrosine phosphatases from 3T3-L1 adipocytes. (1991) (63)
Kinetics of activation of acetyl-CoA carboxylase by citrate. Relationship to the rate of polymerization of the enzyme. (1983) (62)
O-Linked N-Acetylglucosamine Modification on CCAAT Enhancer-binding Protein β (2009) (62)
The enzymatic carboxylation of phosphoenolpyruvate. IV. The binding of manganese and substrates by phosphoenolpyruvate carbosy-kinase and phosphoenolypyruvate carboxylase. (1968) (61)
Effect of centrally administered C75, a fatty acid synthase inhibitor, on ghrelin secretion and its downstream effects. (2005) (61)
Leptin regulates proinflammatory immune responses (1998) (61)
Trans-acting factors involved in adipogenic differentiation. (1993) (60)
Adipocyte Differentiation: When precursors are also regulators (1995) (59)
Monovalent avidin affinity columns. (1990) (58)
LIVER ACETYL COA CARBOXYLASE: THE DISSOCIATION-REASSOCIATION PROCESS AND ITS RELATION TO CATALYTIC ACTIVITY* (1966) (58)
Long-term effects of a fatty acid synthase inhibitor on obese mice: food intake, hypothalamic neuropeptides, and UCP3. (2004) (58)
Identification of phosphorylated 422(aP2) protein as pp15, the 15-kilodalton target of the insulin receptor tyrosine kinase in 3T3-L1 adipocytes. (1988) (57)
Hypothalamic malonyl‐CoA and CPT1c in the treatment of obesity (2011) (56)
Assembly of very low density lipoprotein in the hepatocyte. Differential transport of apoproteins through the secretory pathway. (1988) (56)
Sequential assembly of very low density lipoprotein apolipoproteins, triacylglycerol, and phosphoglycerides by the intact liver cell. (1983) (56)
Insulin-dependent phosphorylation of the insulin receptor-protein kinase and activation of glucose transport in 3T3-L1 adipocytes. (1986) (56)
The enzymatic carboxylation of phosphoenolpyruvate. 3. Investigation of the kinetics and mechanism of the mitochondrial phosphoenolpyruvate carboxykinase-catalyzed reaction. (1966) (56)
Expression of an insulin-responsive glucose transporter (GLUT4) minigene in transgenic mice: effect of exercise and role in glucose homeostasis. (1995) (55)
Mechanism for acute control of fatty acid synthesis by glucagon and 3':5'-cyclic AMP in the liver cell. (1977) (55)
On the mechanism of preadipocyte differentiation. Masking of poly(ADP-ribose) synthetase activity during differentiation of 3T3-L1 preadipocytes. (1981) (55)
The insulin-like growth factor 1 (IGF-1) receptor is responsible for mediating the effects of insulin, IGF-1, and IGF-2 in Xenopus laevis oocytes. (1991) (54)
3-Hydroxy-3-methylgutaryl-CoA synthase. Participation of acetyl-S-enzyme and enzyme-S-hydroxymethylgutaryl-SCoA intermediates in the reaction. (1977) (54)
Post-translational acquisition of insulin binding activity by the insulin proreceptor. Correlation to recognition by autoimmune antibody. (1987) (53)
The polymerization of acetyl-CoA carboxylase. (1983) (52)
Central lactate metabolism suppresses food intake via the hypothalamic AMP kinase/malonyl-CoA signaling pathway. (2009) (52)
Cell Cycle Arrest by Kaposi's Sarcoma-Associated Herpesvirus Replication-Associated Protein Is Mediated at both the Transcriptional and Posttranslational Levels by Binding to CCAAT/Enhancer-Binding Protein α and p21CIP-1 (2003) (52)
Chemical and enzymatic evidence for the participation of a 2-carboxy-3-ketoribitol-1,5-diphosphate intermediate in the carboxylation of ribulose 1,5-diphosphate. (1973) (52)
Possible role of the Golgi apparatus in the assembly of very low density lipoprotein. (1990) (52)
Evidence for different pathways for the degradation of insulin and insulin receptor in the chick liver cell. (1982) (52)
Insulin receptor tyrosine kinase-catalyzed phosphorylation of 422(aP2) protein. Substrate activation by long-chain fatty acid. (1990) (51)
Cell-free transcription directed by the 422 adipose P2 gene promoter: activation by the CCAAT/enhancer binding protein. (1991) (49)
Association and assembly of triglyceride and phospholipid with glycosylated and unglycosylated apoproteins of very low density lipoprotein in the intact liver cell. (1982) (48)
Regulation of insulin receptor metabolism. Differentiation-induced alteration of receptor synthesis and degradation. (1981) (48)
c-Crk, a Substrate of the Insulin-like Growth Factor-1 Receptor Tyrosine Kinase, Functions as an Early Signal Mediator in the Adipocyte Differentiation Process* (2000) (48)
The effects of cycloheximide and chloroquine on insulin receptor metabolism. Differential effects on receptor recycling and inactivation and insulin degradation. (1985) (47)
Localization and effect of ectopic expression of CPT1c in CNS feeding centers. (2007) (46)
Properties and purification of mitochondrial propionyl carboxylase. (1960) (45)
Activation of glucose uptake by insulin and insulin-like growth factor I in Xenopus oocytes. (1989) (44)
Liver acetyl CoA carboxylase: insight into the mechanism of activation by tricarboxylic acids and acetyl CoA. (1967) (43)
Transcription factor NF1 mediates repression of the GLUT4 promoter by cyclic-AMP. (1999) (43)
Propionyl holocarboxylase synthesis. I. Preparation and properties of the enzyme system. (1962) (43)
Homogeneous functional insulin receptor from 3T3-L1 adipocytes. Purification using N alpha B1-(biotinyl-epsilon-aminocaproyl)insulin and avidin-sepharose. (1985) (43)
Relative hydrophobicities of Actinomyces viscosus and Actinomyces naeslundii strains and their adsorption to saliva-treated hydroxyapatite (1985) (43)
3-Hydroxy-3-methylglutaryl coenzyme A synthase. Evidence for an acetyl-S-enzyme intermediate and identification of a cysteinyl sulfhydryl as the site of acetylation. (1975) (43)
Kinetics of insulin receptor transit to and removal from the plasma membrane. (1983) (42)
Expression and function of insulin/insulin-like growth factor I hybrid receptors during differentiation of 3T3-L1 preadipocytes. (1998) (42)
Changes in mammary-gland acetyl-coenzyme A carboxylase associated with lactogenic differentiation. (1977) (42)
Enzymatic carboxylation of biotin: molecular and catalytic properties of a component enzyme of acetyl CoA carboxylase. (1970) (42)
Repression of transcription mediated by dual elements in the CCAAT/enhancer binding protein alpha gene. (1997) (41)
Acute control of fatty acid synthesis by cyclic AMP in the chick liver cell: possible site of inhibition of citrate formation. (1979) (40)
The biochemical function of biotin, VI. Chemical structure of the carboxylated active site of propionyl carboxylase. (1963) (40)
THE ENZYMATIC CARBOXYLATION OF BUTYRYL COENZYME A (1959) (40)
Kinetic evidence for activating and non-activating components of autophosphorylation of the insulin receptor protein kinase. (1986) (39)
Sequential repression and activation of the CCAAT enhancer-binding protein-alpha (C/EBPalpha ) gene during adipogenesis. (2000) (39)
Interaction of ribulose diphosphate carboxylase with 2-carboxyribitol diphosphate, an analogue of the proposed carboxylated intermediate in the CO 2 fixation reaction. (1972) (39)
Expression of a novel insulin-activated amino acid transporter gene during differentiation of 3T3-L1 preadipocytes into adipocytes. (1995) (39)
Acetyl coenzyme A carboxylase. 3. Further studies on the relation of catalytic activity to polymeric state. (1972) (38)
Some enzymic properties of mitochondrial propionyl carboxylase. (1962) (38)
Synthesis, processing, and secretion of apolipoprotein B by the chick liver cell. (1982) (37)
Control of adipocyte differentiation by CCAAT/enhancer binding protein alpha (C/EBP alpha). (1996) (37)
Insulin stimulates fluid-phase endocytosis and exocytosis in 3T3-L1 adipocytes. (1986) (36)
Cell cycle arrest by Kaposi's sarcoma-associated herpesvirus replication-associated protein is mediated at both the transcriptional and posttranslational levels by binding to CCAAT/enhancer-binding protein alpha and p21(CIP-1). (2003) (36)
Insulin depletion leads to adipose-specific cell death in obese but not lean mice. (1998) (35)
Hypothalamic malonyl-coenzyme A and the control of energy balance. (2008) (35)
Acetyl coenzyme A carboxylase. Rapid purification of the chick liver enzyme and steady state kinetic analysis of the carboxylase-catalyzed reaction. (1982) (35)
On the possible involvement of a carbonyl phosphate intermediate in the adenosine triphosphate-dependent carboxylation of biotin. (1972) (35)
Insulin and insulin-like growth factor 1 stimulate the phosphorylation on tyrosine of a 160 kDa cytosolic protein in 3T3-L1 adipocytes. (1988) (34)
[42] Phosphoenolpyruvate carboxykinase from pig liver mitochondria (1969) (34)
The presence of tightly bound copper in ribulose diphosphate carboxylase from spinach. (1969) (34)
Further studies on mitochondrial propionyl carboxylase. (1960) (34)
Propionyl holocarboxylase formation: Covalent bonding of biotin to apocarboxylase lysyl ϵ-amino groups (1962) (34)
CCAAT/enhancer binding protein alpha (C/EBP alpha) undifferentiated protein: a developmentally regulated nuclear protein that binds to the C/EBP alpha gene promoter. (1993) (34)
Acetyl coenzyme A carboxylase. Purification and properties of the bovine adipose tissue enzyme. (1972) (33)
A common mechanism for posttranslational activation of plasma membrane receptors? (1989) (33)
Role of malonyl-CoA in the hypothalamic control of food intake and energy expenditure. (2005) (33)
Cyclic AMP-induced transcriptional repression of the insulin-responsive glucose transporter (GLUT4) gene: identification of a promoter region required for down-regulation of transcription. (1993) (33)
The Blockade of Preadipocyte Differentiation by Protein-tyrosine Phosphatase HA2 Is Reversed by Vanadate (*) (1995) (32)
BMP-4 treatment of C3H10T1/2 stem cells blocks expression of MMP-3 and MMP-13. (2007) (32)
Estradiol-induced alteration of very-low-density lipoprotein assembly. Possible competition among apoproteins for incorporation into nascent very-low-density lipoprotein. (1984) (31)
Overexpression of GLUT4 in mice causes up-regulation of UCP3 mRNA in skeletal muscle. (1999) (31)
A Sequence Element in the GLUT4 Gene That Mediates Repression by Insulin* (1998) (31)
Regulated expression of 5'-deleted mouse GLUT4 minigenes in transgenic mice: effects of exercise training and high-fat diet. (1997) (31)
Multiple phosphorylation of acetyl-CoA carboxylase in chick liver cells. A cyclic AMP-independent process. (1978) (31)
Insulin-Receptor Tyrosine Kinase and Glucose Transport (1990) (31)
Synthesis, processing, and secretion of hepatic very low density lipoprotein (1984) (28)
Effect of phenylarsine oxide on fluid phase endocytosis: Further evidence for activation of the glucose transporter (1989) (28)
Lipoprotein Lipase Suppression in 3T3-L1 Cells by an Endotoxin-induced Mediator from Exudate Cells (1984) (28)
[43] Phosphoenolpyruvate carboxylase from peanut cotyledons (1969) (28)
Characterization of the mouse insulin receptor gene promoter. (1989) (27)
Identification of a transcriptional repressor down-regulated during preadipocyte differentiation. (1992) (27)
Regulated expression of an insulin-responsive glucose transporter (GLUT4) minigene in 3T3-L1 adipocytes and transgenic mice. (1993) (27)
5 Ribulose-1,5-Diphosphate Carboxylase (1972) (26)
Restoration of biotin-deficiency-induced depression of propionyl carboxylase activity in vivo and in vitro. (1961) (26)
Derepression of the C/EBPalpha gene during adipogenesis: identification of AP-2alpha as a repressor. (1998) (26)
Propionyl apocarboxylase activation catalyzed by cell-free enzyme extracts. (1961) (26)
The carboxyl transferase component of acetyl CoA carboxylase: structural evidence for intersubunit translocation of the biotin prosthetic group. (1971) (26)
Upstream stimulatory factors regulate the C/EBP alpha gene during differentiation of 3T3-L1 preadipocytes. (2007) (25)
Effect of serum on the down-regulation of CHOP-10 during differentiation of 3T3-L1 preadipocytes. (2005) (24)
Identification and partial purification of the insulin-responsive glucose transporter from 3T3-L1 adipocytes. (1986) (24)
CHAPTER 2 – Regulation of Fatty Acid Synthesis in Animal Tissues (1971) (24)
Cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase from chicken liver. (1975) (24)
Liver acetyl coenzyme A carboxylase: activation of model partial reactions by tricarboxylic acids. (1968) (24)
Insulin receptor synthesis and turnover in differentiating 3T3-L1 preadipocytes. (1980) (23)
Studies on methylmalonyl isomerase. (1962) (23)
Binding of insulin to solubilized insulin receptor from human placenta. Evidence for a single class of noninteracting binding sites. (1983) (22)
The enzymatic carboxylation of phosphoenolpyruvate. V. Kinetic and 18-O studies on liver mitochondrial phosphoenolpyruvate carboxykinase. (1968) (22)
Loss of choleragen receptors and ganglioside upon differentiation of 3T3-L1 preadipocytes. (1980) (22)
Purification and properties of phosphoenolpyruvate carboxylase from the germinating peanut cotyledon. (1962) (22)
[70] Ribulose-diphosphate carboxylase from spinach leaves (1975) (21)
Multiple cytosolic forms of hepatic β-hydroxy-β-methyglutaryl coA synthase: Possible regulatory role in cholesterol synthesis (1972) (20)
Exchange characteristics of the amide protons of d-biotin and derivatives: implications for the mechanism of biotin enzymes and the role of sulfur in biotin (1985) (20)
Effect of differentiation on the adenylate cyclase system of 3T3-C2 and 3T3-L1 cells. Determination of choleragen substrates in differentiating 3T3-L1 and nondifferentiating 3T3-C2 cells. (1982) (20)
Tricarboxylic acid activator-induced changes at the active site of acetyl-CoA carboxylase. (1970) (17)
Hormonal regulation of acetyl-CoA carboxylase activity in the liver cell. (1979) (16)
Transcarboxylation and CO2 “exchange” catalyzed by purified propionyl carboxylase (1960) (16)
Post-translational processing and activation of insulin and EGF proreceptors. (1985) (16)
Expression of insulin receptors during preadipocyte differentiation. (1980) (15)
Phosphotyrosyl Turnover in Insulin Signaling (1991) (14)
Downregulation of repressive CUP/AP-2 isoforms during adipocyte differentiation. (2001) (14)
Subunit size and paracrystal structure of avian liver acetyl-CoA carboxylase. (1978) (14)
The activation of acetyl CoA carboxylase by tricarboxylic acids. (1970) (14)
Tricarboxylic acid cycle intermediates and the control of fatty acid synthesis and ketogenesis. (1981) (14)
Completing the loop: neuron-adipocyte interactions and the control of energy homeostasis. (2002) (13)
Nuclear factor 1 regulates adipose tissue-specific expression in the mouse GLUT4 gene. (2004) (12)
Insulin-activated tyrosine phosphorylation of a 15-kilodalton protein in intact 3 T 3L 1 adipocytes ( insulin receptor / tyrosine kinase / phosphotyrosine / phenylarsine oxide / dithiol ) (12)
Acetyl coenzyme A carboxylase. Subunit structure of the protomeric form of the avian liver enzyme. (1974) (12)
Molecular structure and intermolecular interactions of N1'-methoxycarbonylbiotin methyl ester: a model for carboxybiotin. (1980) (11)
Acetyl coenzyme A carboxylase. IV. Biotinyl prosthetic group-independent malonyl coenzyme A decarboxylation and carbosyl transfer: generalization to other biotin enzymes. (1972) (11)
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase from chicken liver. (1975) (11)
William C. Rose lectureship in biochemistry and nutrition: The regulation of insulin receptor level and activity. (2009) (11)
3-Hydroxy-3-methylglutaryl coenzyme A synthase: use of a spin-labeled probe to study acyl coenzyme A binding. (1979) (11)
Increase in translatable mRNA for mitochondrial pyruvate carboxylase during differentiation of 3T3 preadipocytes. (1981) (11)
Receptor Affinity Chromatography (1985) (10)
Control of ketogenesis and fatty-acid synthesis at the mitochondrial branch-point for acetyl-CoA in the chick liver cell: effect of adenosine 3',5'-monophosphate. (1982) (10)
NPY and neuron-adipocyte interactions in the regulation of metabolism. (2006) (10)
[21] Cytosolic acetoacetyl-CoA thiolase from chicken liver (1975) (10)
Regulatory sequence elements of mouse GLUT4 gene expression in adipose tissues. (2003) (10)
Regulation of Insulin Receptor Metabolism (1981) (10)
Very low density lipoprotein synthesis and secretion. Extrusion of apoprotein B nascent chains through the membrane of the endoplasmic reticulum without protein synthesis. (1981) (10)
Further studies on the mechanism of the enzymic carboxylation of propionyl-CoA. (1961) (9)
Net synthesis of methylmalonyl-CoA by ADP-, ATP-, and Mg-independent transcarboxylation catalyzed by propionyl carboxylase. (1961) (9)
Influence of physicochemical parameters on adsorption of Actinomyces viscosus to hydroxyapatite surfaces (1983) (9)
Alterations in insulin binding accompanying differentiation of 3 T 3L 1 preadipocytes ( insulin receptor / epidermal growth factor ) (9)
Carboxyltransferase component of acetyl-CoA carboxylase from Escherichia coli. (1975) (8)
Investigation of the mechanism of enzymatic carboxylation of phosphoenolpyruvate. (1962) (8)
A 30-kDa alternative translation product of the CCAAT / enhancer binding protein a message : Transcriptional activator lacking antimitotic activity ( 3 T 3L 1 cells / preadipocyte / adipocyte / differentiation / liver ) (2005) (7)
[78] Mitochondrial propionyl carboxylase: (1962) (7)
Trapping of a novel coenzyme A containing intermediate of 3-hydroxy-3-methylglutaryl-CoA synthase. (1976) (7)
Biosynthesis of the epidermal growth factor receptor: post-translational glycosylation-independent acquisition of tyrosine kinase autophosphorylation activity. (1988) (7)
The mitochondrion updated. (1986) (7)
C/EBPalpha reverses the anti-adipogenic effects of the HIV protease inhibitor nelfinavir. (2005) (7)
Obese gene expression at in vivo levels by fat pads derived from s . c . implanted 3 T 3F 442 A preadipocytes ( adipocytes y differentiation y obesity y adipose y leptin ) (1997) (7)
Crystallization of biotin carboxylase, a component enzyme of the acetyl-CoA carboxylase system from Escherichia coli. (1971) (7)
Insulin receptor synthesis and turnover in differentiating 3 T 3L 1 preadipocytes ( insulin receptor half-life / receptor density shift / isopycnic banding on CsCl gradients / 3 T 3L 1 adipocytes ) (2003) (6)
Insulin down-regulates expression of the insulin-responsive glucose transporter ( GLUT 4 ) gene : Effects on transcription and mRNA turnover [ 3 T 3L 1 adipocyte , non-insulin-dependent ( tpe 2 ) diabetes mellitus / glucose uptake / insulin resistancel (6)
Kinetics of Citrate‐induced Activation and Polymerization of Chick Liver Acetyl‐CoA Carboxylase a (1985) (6)
Sequential repression and activation of the CCAAT enhancer-binding protein-a (CyEBPa) gene during adipogenesis (2000) (6)
Post-translational acquisition of ligand binding- and tyrosine kinase-domain function by the epidermal growth factor and insulin receptors. (1987) (6)
Biotin carboxylase component of acetyl-CoA carboxylase from Escherichia coli. (1975) (6)
The adipose tissue/central nervous system axis (1997) (6)
NMR Studies of the Exchange of the Amide Protons of d‐Biotin and Its Derivatives a (1985) (5)
Cell Cycle Arrest by Kaposi’s Sarcoma-Associated Herpesvirus Replication-Associated Protein Is Mediated at both the Transcriptional and Posttranslational Levels by Binding to CCAAT/Enhancer-Binding Protein and p21 (2003) (5)
Erratum: Sequential gene promoter interactions of C/EBPβ, C/EBPα, and PPARγ during adipogenesis (Biochemical and Biophysical Research Communications (2004) 319 (235-239) DOI: 10.1016/j.bbrc.2004.04.176) (2004) (5)
Posttranslational processing of the insulin proreceptor. (1985) (4)
The Biotin Connection: Severo Ochoa, Harland Wood, and Feodor Lynen (2004) (4)
Control of adipocyte differentiation by CCAAT/enhancer binding proteinα (C/EBPα) (1996) (4)
Studies on the function of vitamin A in metabolism by the use of radioactive metabolic intermediates. (1958) (3)
Alterations in cyclic AMP phosphodiesterase activities during differentiation of 3T3-L1 cells. (1983) (3)
STUDIES O F I NSULIN R ESISTANCE I N A DIPOCYTES INDUCED BY MACROPHAGE M EDIATOR (1983) (3)
Propionyl holocarboxylase formation: covalent bonding of biotin to apocarboxylase lysyl epsilon-amino groups. (1962) (3)
Mechanism of action of ribulose bisphosphate carboxylase/oxygenase. (1978) (3)
Regulation of Insulin Receptor 1 (IRS-1)/AKT Kinase Mediated Insulin Signaling by O-linked β -N-acetylglucosamine (O-GlcNAc) in 3T3-L1 Adipocytes. (2009) (3)
Expression and function of insulin / insulin-like growth factor I hybrid receptors during differentiation of 3 T 3L 1 preadipocytes (1998) (3)
Regulation of insulin synthesis in an insulin-producing cell line (RINm5F): Long-term experiments (1989) (2)
Energy Balance, Obesity and Type‐2 Diabetes (2009) (2)
Calcium Sensitivity of Glutamate Release in a Calyx-Type Terminal (2000) (2)
Cytosolic acetoacetyl-CoA thiolase from chicken liver. (1975) (2)
Hormonal and developmental control of gene expression in wheat (2016) (1)
Mouse insulin-responsive glucose transporter gene : Characterization of the gene and transactivation by the CCAAT / enhancer binding protein ( C / EBP 3 T 3-Ll preadipocyte / Spl ) (1)
Use of the heavy-isotope density-shift method to investigate insulin receptor synthesis, turnover, and processing. (1983) (1)
Insulin and insulin-like growth factor 1 stimulate the phosphorylation on tyrosine of a 160 kDa cytosolic protein in 3 T 3L 1 adipocytes (2005) (1)
Insulin-Activated Phosphorylation on Tyrosine of a 15 Kilodalton Cytosolic Protein in 3T3-L1 Adipocytes (1987) (1)
Post-translational glycosylation of inactive aglyco-insulin receptor accumulated during tunicamycin treatment (1981) (1)
Regulation of expression of specific mRNAs during differentiation of 3T3-L1 cells (1985) (0)
REGULATION OF INSULIN RECEPTOR METABOLISM: MECHANISM OF INSULIN-INDUCED RECEPTOR DOWN-REGULATION (1983) (0)
Effects of insulin and dexamethasone on insulin receptor metabolism in 3T3-C2 fibroblasts (1982) (0)
Regulation of Fat Metabolism in Animals: Relevance to Obesity and Disease (2003) (0)
CCAAT / enhancer binding protein a is sufficient to initiate the 3 T 3L 1 adipocyte differentiation program ( 3 T 3L 1 preadlpocyte / 422 adipose P 2 protein / glucose twansporter 4 ) (0)
Transcriptional repression of the mouse insulin-responsive glucose transporter ( GLUT 4 ) gene by cAMP ( 3 T 3L 1 adipocytes / adipose tissue / forskolin / erythrocyte / brain glucose transporter ) (0)
Cell-free transcription directed by the 422 adipose P 2 gene promoter : Activation by the CCAAT / enhancer binding protein ( 3 T 3-Ll preadipocyte / differentiation / cycic AMP / stearoyl-CoA desaturase / glucose transporter ) (0)
mammary tissue . Changes in nutritional and hormonal status lead to alterations in both the rates of carboxylase synthesis and degradation in liver (2005) (0)
Effect of cAMP on insulin-induced acetyl-CoA carboxylase (CBX) synthesis (1978) (0)
Binding of insulin (INS) and epidermal growth factor (EGF) to 3T3-LI fibroblasts, a 'preadipocyte' cell line (1977) (0)
Role of calpain in adipocyte differentiation (3T3-L1 adipocytesycalpastatinycAMPyN-acetyl-Leu-Leu-norleucinalyCCAAT) (1999) (0)
Identification of phosphorylated 422 ( aP 2 ) protein as ppl 5 , the 15-kilodalton target of the insulin receptor tyrosine kinase in 3 T 3L 1 adipocytes ( phosphotyrosine / fatty acid binding protein ) (0)
Promoter-eDNA-directed heterologous protein expression in Xenopus laevis oocytes (2004) (0)
Multiple cytosolic forms of hepatic beta-hydroxy-beta-methyglutaryl CoA synthase: possible regulatory role in cholesterol synthesis. (1972) (0)
Comparison of Rates of Oxidation of Propionate-2-C14 by Liver Slices from the Calf and Mature Bovine (1960) (0)
Differentiation-induced mRNA synthesis by 3T3-L1 adipocytes: cDNA cloning and identification of a myelin P2-like mRNA (1984) (0)
Effect of a fatty acid synthas intake and expression of hyp neuropeptides (2016) (0)
Mechanism of insulin-induced receptor down-regulation in differentiated 3T3-L1 adipocytes (1982) (0)
Malonyl-CoA Signaling in the CNS: Hypothalamic Control of Feeding Behavior and Energy Expenditure (2011) (0)
Early Studies on Role of Stearoyl-CoA Desaturase During Preadipocyte Differentiation (2013) (0)
The adipose tissue/central nervous system axis (1997) (0)
Transcriptional activation of the mouse obese ( ob ) gene by CCAAT / enhancer binding protein a ( 3 T 3-Ll / preadipocytes and adipocytes / leptin / differentiation / obesity ) (2005) (0)
Mitotic clonal expansion: A s required for adipogenesis (2016) (0)
MECHANISM AND REGULATION OF ACETYL CoA CARBOXYLATION: INTERSUBUNIT TRANSLOCATION OF THE BIOTIN PROSTHETIC GROUP* (1972) (0)
Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic (2002) (0)
THE DISSOCIA TION-REASSOCIA TION PROCESS AND ITS RELATION TO CATALYTIC ACTIVITY* (2016) (0)

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