Morris F. White
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Philosophy Biology
Morris F. White's Degrees
- Doctorate Medicine Stanford University
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(Suggest an Edit or Addition)Morris F. White's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance (1996) (2631)
- Disruption of IRS-2 causes type 2 diabetes in mice (1998) (1809)
- The insulin signaling system. (1994) (1654)
- Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle* (2002) (1577)
- Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein (1991) (1486)
- Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. (1999) (1226)
- The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307 * (2000) (1155)
- Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action* (2002) (959)
- IRS proteins and the common path to diabetes. (2002) (927)
- SOCS-1 and SOCS-3 Block Insulin Signaling by Ubiquitin-mediated Degradation of IRS1 and IRS2* (2002) (892)
- Role of IRS-2 in insulin and cytokine signalling (1995) (892)
- Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. (2005) (801)
- Insulin Signaling in Health and Disease (2003) (762)
- Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 (2012) (746)
- The SH2/SH3 domain‐containing protein GRB2 interacts with tyrosine‐phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. (1993) (643)
- Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. (1999) (601)
- The IRS-signalling system: A network of docking proteins that mediate insulin action (1998) (592)
- The insulin signalling system and the IRS proteins (1997) (582)
- Irs-2 coordinates Igf-1 receptor-mediated β-cell development and peripheral insulin signalling (1999) (574)
- Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells (1985) (564)
- The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. (2002) (541)
- Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. (2001) (537)
- Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity (1987) (518)
- Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. (2000) (513)
- cAMP promotes pancreatic β-cell survival via CREB-mediated induction of IRS2 (2003) (503)
- Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1 (1993) (463)
- IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. (1992) (460)
- Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation (2003) (458)
- Activation of phosphatidylinositol 3-kinase by insulin. (1990) (450)
- IRS-2 pathways integrate female reproduction and energy homeostasis (2000) (446)
- Tumor Necrosis Factor (TNF)-α Inhibits Insulin Signaling through Stimulation of the p55 TNF Receptor and Activation of Sphingomyelinase* (1996) (425)
- IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells. (1993) (419)
- Tyrosine Dephosphorylation and Deactivation of Insulin Receptor Substrate-1 by Protein-tyrosine Phosphatase 1B (2000) (417)
- c-Jun N-terminal Kinase (JNK) Mediates Feedback Inhibition of the Insulin Signaling Cascade* (2003) (417)
- A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor. (1988) (393)
- Cross-talk between the insulin and angiotensin signaling systems. (1996) (391)
- The insulin receptor and the molecular mechanism of insulin action. (1988) (389)
- Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. (2008) (386)
- Insulin signaling meets mitochondria in metabolism (2010) (374)
- Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis (2007) (371)
- Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance. (1992) (345)
- Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity (1988) (339)
- Insulin signal transduction and the IRS proteins. (1996) (331)
- An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth (1994) (323)
- The IRS-1 signaling system. (1994) (322)
- cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. (2003) (320)
- The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action. (1998) (318)
- Cyclins D2 and D1 Are Essential for Postnatal Pancreatic β-Cell Growth (2005) (314)
- Expression and function of IRS-1 in insulin signal transmission. (1992) (307)
- IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase. (1993) (303)
- Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. (2004) (301)
- Contrasting Effects of IRS-1 Versus IRS-2 Gene Disruption on Carbohydrate and Lipid Metabolism in Vivo * (2000) (290)
- Insulin-like signaling, nutrient homeostasis, and life span. (2008) (289)
- Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity. (1988) (279)
- The IRS‐signalling system during insulin and cytokine action (1997) (278)
- Foxo1 integrates insulin signaling with mitochondrial function in the liver (2009) (277)
- Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction (2011) (265)
- Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. (2003) (264)
- Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation. (1994) (258)
- Growth Hormone, Interferon-γ, and Leukemia Inhibitory Factor Promoted Tyrosyl Phosphorylation of Insulin Receptor Substrate-1 (*) (1995) (256)
- Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells. (1998) (248)
- RIP-Cre Revisited, Evidence for Impairments of Pancreatic β-Cell Function* (2006) (244)
- Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase (1996) (240)
- The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase (1995) (234)
- Regulation of Phosphatidylinositol 3′-Kinase by Tyrosyl Phosphoproteins (1995) (231)
- 4PS/Insulin Receptor Substrate (IRS)-2 Is the Alternative Substrate of the Insulin Receptor in IRS-1-deficient Mice (*) (1995) (229)
- Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice (2005) (226)
- PTB Domains of IRS-1 and Shc Have Distinct but Overlapping Binding Specificities (*) (1995) (225)
- Role of IRS-1-GRB-2 complexes in insulin signaling (1994) (224)
- The New Elements of Insulin Signaling: Insulin Receptor Substrate-1 and Proteins With SH2 Domains (1993) (213)
- Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. (2005) (212)
- Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. (1993) (209)
- Regulation of Insulin/Insulin-like Growth Factor-1 Signaling by Proteasome-mediated Degradation of Insulin Receptor Substrate-2* (2001) (200)
- Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. (2006) (196)
- Interferon-α Engages the Insulin Receptor Substrate-1 to Associate with the Phosphatidylinositol 3′-Kinase (*) (1995) (194)
- Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells. (1984) (194)
- Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models. (2011) (189)
- Irs1 serine 307 promotes insulin sensitivity in mice. (2010) (185)
- Insulin Receptor Substrate-1 is the Predominant Signaling Molecule Activated by Insulin-like Growth Factor-I, Insulin, and Interleukin-4 in Estrogen Receptor-positive Human Breast Cancer Cells* (1998) (178)
- Exendin-4 Uses Irs2 Signaling to Mediate Pancreatic β Cell Growth and Function* (2006) (178)
- SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange (1993) (173)
- Molecular insights into insulin action and secretion (2002) (172)
- Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells. (1993) (171)
- Essential Role of Insulin Receptor Substrate-2 in Insulin Stimulation of Glut4 Translocation and Glucose Uptake in Brown Adipocytes* (2000) (171)
- The Pleckstrin Homology Domain Is the Principle Link between the Insulin Receptor and IRS-1* (1996) (168)
- Defective insulin secretion in pancreatic β cells lacking type 1 IGF receptor (2002) (166)
- Calmodulin Activates Phosphatidylinositol 3-Kinase* (1997) (166)
- IRS proteins and beta-cell function. (2001) (165)
- Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation. (2004) (163)
- Insulin Receptor Substrate-2 Binds to the Insulin Receptor through Its Phosphotyrosine-binding Domain and through a Newly Identified Domain Comprising Amino Acids 591786 (*) (1996) (163)
- Pdx1 restores β cell function in Irs2 knockout mice (2002) (162)
- The COOH-terminal Tyrosine Phosphorylation Sites on IRS-1 Bind SHP-2 and Negatively Regulate Insulin Signaling* (1998) (160)
- Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways (2010) (159)
- Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase. (1991) (155)
- Interleukins 2, 4, 7, and 15 Stimulate Tyrosine Phosphorylation of Insulin Receptor Substrates 1 and 2 in T Cells POTENTIAL ROLE OF JAK KINASES (*) (1995) (153)
- Interleukin-4-mediated Protection of Primary B Cells from Apoptosis through Stat6-dependent Up-regulation of Bcl-xL* (2002) (151)
- Regulating insulin signaling and β-cell function through IRS proteinsThis paper is one of a selection of papers published in this Special Issue, entitled Second Messengers and Phosphoproteins—12th International Conference. (2006) (150)
- Human IL6 enhances leptin action in mice (2009) (149)
- Activation of the phosphatidylinositol 3-kinase serine kinase by IFN-alpha. (1997) (148)
- Response to Comment on "Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis" (2008) (145)
- Kinetic properties and sites of autophosphorylation of the partially purified insulin receptor from hepatoma cells. (1984) (145)
- YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase. (1992) (145)
- Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes. (2003) (145)
- The Type I Interferon Receptor Mediates Tyrosine Phosphorylation of Insulin Receptor Substrate 2 (*) (1996) (144)
- Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling (2012) (139)
- The Irs1 Branch of the Insulin Signaling Cascade Plays a Dominant Role in Hepatic Nutrient Homeostasis (2009) (138)
- Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: therapeutic implications. (2002) (137)
- Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. Formation of binary and ternary signaling complexes in intact cells. (1993) (137)
- Requirement of protein kinase C zeta for stimulation of protein synthesis by insulin (1997) (134)
- The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action. (1997) (133)
- Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control. (1988) (132)
- The Fyn Tyrosine Kinase Binds Irs-1 and Forms a Distinct Signaling Complex during Insulin Stimulation (*) (1996) (130)
- Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and Is Controlled by p38α MAPK During Insulin Resistance (2013) (130)
- Disruption of the SH2-B Gene Causes Age-Dependent Insulin Resistance and Glucose Intolerance (2004) (127)
- Insulin receptor kinase domain autophosphorylation regulates receptor enzymatic function. (1992) (127)
- Insulin receptor substrate proteins and diabetes (2004) (127)
- Growth Hormone, Interferon-γ, and Leukemia Inhibitory Factor Utilize Insulin Receptor Substrate-2 in Intracellular Signaling* (1996) (126)
- Involvement of Insulin Receptor Substrate 2 in Mammary Tumor Metastasis (2004) (126)
- Characterization of the insulin receptor kinase purified from human placental membranes. (1983) (125)
- Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation. (1992) (125)
- Janus Kinase-dependent Activation of Insulin Receptor Substrate 1 in Response to Interleukin-4, Oncostatin M, and the Interferons* (1997) (124)
- Muscle-Specific IRS-1 Ser→Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle (2008) (120)
- Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells. (1999) (119)
- Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. (2002) (118)
- A naturally occurring mutation of insulin receptor alanine 1134 impairs tyrosine kinase function and is associated with dominantly inherited insulin resistance. (1990) (118)
- Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function. (2006) (117)
- The IRS-pathway operates distinctively from the Stat-pathway in hematopoietic cells and transduces common and distinct signals during engagement of the insulin or interferon-alpha receptors. (1997) (114)
- Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit. (1990) (114)
- The Pleckstrin Homology Domain in Insulin Receptor Substrate-1 Sensitizes Insulin Signaling (*) (1995) (114)
- Targeted Disruption of ROCK1 Causes Insulin Resistance in Vivo* (2009) (113)
- Differences in the sites of phosphorylation of the insulin receptor in vivo and in vitro. (1985) (110)
- APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor (2014) (110)
- Genetic Deficiency of Glycogen Synthase Kinase-3β Corrects Diabetes in Mouse Models of Insulin Resistance (2008) (109)
- Chronic activation of a designer G(q)-coupled receptor improves β cell function. (2013) (109)
- Regulating insulin signaling and beta-cell function through IRS proteins. (2006) (109)
- Insulin Receptor Substrate-2 Is Not Necessary for Insulin- and Exercise-stimulated Glucose Transport in Skeletal Muscle* (1999) (108)
- Human Skeletal Muscle Insulin Receptor Substrate-1: Characterization of the cDNA, Gene, and Chromosomal Localization (1993) (108)
- The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action. (1998) (107)
- The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities. Analysis with insulin and anti-receptor antibodies. (1992) (105)
- Characterization of an endogenous substrate of the insulin receptor in cultured cells. (1987) (104)
- Stat6 and IRS-2 Cooperate in Interleukin 4 (IL-4)-Induced Proliferation and Differentiation but Are Dispensable for IL-4-Dependent Rescue from Apoptosis (2002) (102)
- Pdx1 restores beta cell function in Irs2 knockout mice. (2002) (102)
- Perspective: The Insulin Signaling System-A Common Link in the Pathogenesis of Type 2 Diabetes. (2000) (101)
- Nutrient-dependent and Insulin-stimulated Phosphorylation of Insulin Receptor Substrate-1 on Serine 302 Correlates with Increased Insulin Signaling* (2004) (100)
- A defective intramolecular autoactivation cascade may cause the reduced kinase activity of the skeletal muscle insulin receptor from patients with non-insulin-dependent diabetes mellitus. (1989) (99)
- Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane region (1991) (99)
- Predominance of tyrosine phosphorylation of insulin receptors during the initial response of intact cells to insulin. (1985) (98)
- Enhanced expression of the insulin receptor substrate-2 docking protein in human pancreatic cancer. (1998) (98)
- IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease. (2011) (98)
- Suppression of Insulin Receptor Substrate 1 (IRS-1) Promotes Mammary Tumor Metastasis (2006) (98)
- Insulin receptor substrate signaling suppresses neonatal autophagy in the heart. (2013) (97)
- The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals (1992) (96)
- Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor. (1993) (96)
- YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites (1996) (94)
- The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis (1996) (93)
- The insulin receptor and its substrate: molecular determinants of early events in insulin action. (1993) (90)
- The 60 kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells. (1997) (89)
- Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2 (2008) (89)
- Direct Autocrine Action of Insulin on β-Cells: Does It Make Physiological Sense? (2013) (88)
- Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling. (1999) (87)
- The Pleckstrin Homology and Phosphotyrosine Binding Domains of Insulin Receptor Substrate 1 Mediate Inhibition of Apoptosis by Insulin (1998) (85)
- Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes. (1993) (84)
- Insulin-like growth factor I rapidly stimulates tyrosine phosphorylation of a Mr 185,000 protein in intact cells. (1987) (84)
- Insulin receptor substrate-1 (IRS-1) expression in rat brain. (1994) (84)
- Insulin binding and insulin-dependent phosphorylation of the insulin receptor solubilized from human erythrocytes. (1983) (84)
- Insulin Receptor Substrates Are Essential for the Bioenergetic and Hypertrophic Response of the Heart to Exercise Training (2014) (83)
- Direct visualization of the phosphorylated epidermal growth factor receptor during its internalization in A-431 cells (1987) (82)
- The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth. (1990) (82)
- Insulin signaling after exercise in insulin receptor substrate-2-deficient mice. (2002) (81)
- Insulin Receptor Substrate 2 Is Essential for Maturation and Survival of Photoreceptor Cells (2005) (79)
- Phosphorylation and dephosphorylation of the insulin receptor: evidence against an intrinsic phosphatase activity. (1984) (77)
- Adapter Function of Protein-tyrosine Phosphatase 1D in Insulin Receptor/Insulin Receptor Substrate-1 Interaction (*) (1995) (76)
- IRS Pleckstrin Homology Domains Bind to Acidic Motifs in Proteins* (1998) (76)
- Insulin and Metabolic Stress Stimulate Multisite Serine/Threonine Phosphorylation of Insulin Receptor Substrate 1 and Inhibit Tyrosine Phosphorylation* (2014) (74)
- Insulin-like Growth Factor I (IGF-I)-stimulated Pancreatic β-Cell Growth Is Glucose-dependent (1998) (73)
- Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II. (1993) (72)
- Increased protein kinase C activity is linked to reduced insulin receptor autophosphorylation in liver of starved rats. (1990) (71)
- IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity (2014) (71)
- The insulin receptor functions normally in Chinese hamster ovary cells after truncation of the C terminus. (1991) (70)
- Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice. (2004) (70)
- Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786. (1996) (69)
- Interferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinase. (1995) (68)
- Tyrosine phosphorylation of the insulin receptor during insulin-stimulated internalization in rat hepatoma cells. (1989) (68)
- Immunocytochemical detection of insulin receptor substrate-1 (IRS-1) in rat brain: colocalization with phosphotyrosine (1993) (67)
- Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase (1993) (66)
- IRS-2 Deficiency Impairs NMDA Receptor-Dependent Long-term Potentiation (2011) (66)
- IRS-4 Mediates Protein Kinase B Signaling during Insulin Stimulation without Promoting Antiapoptosis (2000) (65)
- Tyr624 and Tyr628 in Insulin Receptor Substrate-2 Mediate Its Association with the Insulin Receptor* (1997) (65)
- Signaling Pathways: The Benefits of Good Communication (2004) (65)
- IRS‐2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes (2004) (64)
- IRS proteins and diabetic complications (2016) (63)
- The Repression of IRS2 Gene by ATF3, a Stress-Inducible Gene, Contributes to Pancreatic β-Cell Apoptosis (2008) (62)
- Phosphorylation of the insulin receptor in cultured hepatoma cells and a solubilized system. (1985) (61)
- Role of Insulin Receptor Substrates and Protein Kinase C-ζ in Vascular Permeability Factor/Vascular Endothelial Growth Factor Expression in Pancreatic Cancer Cells* (2004) (60)
- Insulin receptor substrate (IRS) proteins IRS-1 and IRS-2 differential signaling in the insulin/insulin-like growth factor-I pathways in fetal brown adipocytes. (1998) (60)
- Heterologous Pleckstrin Homology Domains Do Not Couple IRS-1 to the Insulin Receptor* (1997) (60)
- New frontiers in insulin receptor substrate signaling (1995) (60)
- Regulation of insulin receptor internalization in vascular endothelial cells by insulin and phorbol ester. (1987) (60)
- Inhibition of TNF-α Improves the Bladder Dysfunction That Is Associated With Type 2 Diabetes (2012) (59)
- The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells. (1990) (58)
- Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1. (2011) (58)
- The IRS-signalling system in insulin and cytokine action. (1996) (57)
- Inactivating hepatic follistatin alleviates hyperglycemia (2018) (57)
- The IRS-1 signaling system. (1994) (57)
- The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling. (2006) (55)
- Genetic Inactivation of Pyruvate Dehydrogenase Kinases Improves Hepatic Insulin Resistance Induced Diabetes (2013) (54)
- IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action. (2012) (53)
- Withers, D. J. et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391, 900-904 (1998) (53)
- Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity. (2004) (52)
- Serine Phosphorylation Sites on IRS2 Activated by Angiotensin II and Protein Kinase C To Induce Selective Insulin Resistance in Endothelial Cells (2013) (52)
- Phosphatase and Tensin Homolog Regulation of Islet Growth and Glucose Homeostasis* (2005) (51)
- Insulin action at a molecular level – 100 years of progress (2021) (50)
- Ca2+ regulates calmodulin binding to IQ motifs in IRS-1. (1996) (50)
- Conformational changes in the alpha- and beta-subunits of the insulin receptor identified by anti-peptide antibodies. (1989) (50)
- Interaction of p59fyn with interferon-activated Jak kinases. (1997) (49)
- Inhibition of Insulin Signaling in Endothelial Cells by Protein Kinase C-induced Phosphorylation of p85 Subunit of Phosphatidylinositol 3-Kinase (PI3K)* (2011) (49)
- Insulin-induced egr-1 and c-fos Expression in 32D Cells Requires Insulin Receptor, Shc, and Mitogen-activated Protein Kinase, but Not Insulin Receptor Substrate-1 and Phosphatidylinositol 3-Kinase Activation* (1996) (49)
- 7 The Insulin Receptor and Tyrosine Phosphorylation (1986) (47)
- The juxtamembrane regions of the epidermal growth factor receptor and gp185erbB-2 determine the specificity of signal transduction (1991) (47)
- Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity (2017) (47)
- Autophosphorylation and kinase activity of insulin receptor in diabetic rats. (1986) (47)
- Phosphorylation of glycolytic and gluconeogenic enzymes by the insulin receptor kinase (1987) (46)
- Molecular mechanism(s) of burn-induced insulin resistance in murine skeletal muscle: role of IRS phosphorylation. (2005) (45)
- Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. (2005) (44)
- Cascade of autophosphorylation in the β‐subunit of the insulin receptor (1989) (44)
- Tyrosine phosphorylation of the insulin receptor is not required for receptor internalization: studies in 2,4-dinitrophenol-treated cells. (1989) (42)
- Tyrosine phosphorylations in vivo associated with v-fms transformation (1988) (42)
- Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition (2018) (42)
- Differential regulation of insulin receptor substrate-2 and mitogen-activated protein kinase tyrosine phosphorylation by phosphatidylinositol 3-kinase inhibitors in SH-SY5Y human neuroblastoma cells. (1998) (41)
- Characterization of the Interleukin-4 Nuclear Activated Factor/STAT and Its Activation Independent of the Insulin Receptor Substrate Proteins (*) (1995) (41)
- Insulin stimulates tyrosine phosphorylation of multiple high molecular weight substrates in Fao hepatoma cells. (1992) (40)
- Interactive roles of Ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes. (1994) (39)
- Phosphorylation of Irs1 at SER-522 inhibits insulin signaling. (2007) (39)
- Association of Insulin Receptor Substrate 1 (IRS-1) Y895 with Grb-2 Mediates the Insulin Signaling Involved in IRS-1-Deficient Brown Adipocyte Mitogenesis (2001) (39)
- Compensatory alterations for insulin signal transduction and glucose transport in insulin-resistant diabetes. (1995) (37)
- Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin. (1991) (36)
- Phosphorylation of insulin-like growth factor I receptor by insulin receptor tyrosine kinase in intact cultured skeletal muscle cells. (1988) (36)
- Nonphosphorylatable substrate analogs selectively block autophosphorylation and activation of the insulin receptor, epidermal growth factor receptor, and pp60v-src kinases. (1989) (36)
- Interaction of the insulin receptor kinase with serine/threonine kinases in vitro (1985) (35)
- Cytoplasmic juxtamembrane region of the insulin receptor: a critical role in ATP binding, endogenous substrate phosphorylation, and insulin-stimulated bioeffects in CHO cells. (1991) (34)
- Insulin-like Growth Factor I (IGF-I)-stimulated Pancreatic b-Cell Growth Is Glucose-dependent SYNERGISTIC ACTIVATION OF INSULIN RECEPTOR SUBSTRATE-MEDIATED SIGNAL TRANSDUCTION PATHWAYS BY GLUCOSE AND IGF-I IN INS-1 CELLS* (1998) (34)
- IRS proteins and β-cell function (2001) (34)
- Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis★ (2013) (33)
- Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver (2018) (33)
- Abnormality of insulin binding and receptor phosphorylation in an insulin-resistant melanoma cell line (1984) (33)
- Functional domains of the insulin receptor responsible for chemotactic signaling. (1994) (33)
- The AKTion in non-canonical insulin signaling (2012) (32)
- The insulin receptor substrate-1-related 4PS substrate but not the interleukin-2R gamma chain is involved in interleukin-13-mediated signal transduction. (1995) (32)
- Insulin resistance in thermally-injured rats is associated with post-receptor alterations in skeletal muscle, liver and adipose tissue. (2004) (32)
- G protein-coupled receptors (GPCRs) That Signal via Protein Kinase A (PKA) Cross-talk at Insulin Receptor Substrate 1 (IRS1) to Activate the phosphatidylinositol 3-kinase (PI3K)/AKT Pathway* (2016) (32)
- Integrating metabolism and longevity through insulin and IGF1 signaling. (2013) (31)
- Interaction of insulin receptor substrate-1 (IRS-1) with phosphatidylinositol 3-kinase: effect of substitution of serine for alanine in potential IRS-1 serine phosphorylation sites. (1998) (31)
- The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth (2021) (31)
- Insulin Receptor Substrate 2 Plays Diverse Cell-specific Roles in the Regulation of Glucose Transport* (2005) (31)
- Perspective: The insulin signaling system--a common link in the pathogenesis of type 2 diabetes. (2000) (30)
- Insulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif (1995) (29)
- Structure and function of tyrosine kinase receptors (1991) (29)
- Irs2 inactivation suppresses tumor progression in Pten+/- mice. (2009) (29)
- Specificity of Interleukin-2 Receptor γ Chain Superfamily Cytokines Is Mediated by Insulin Receptor Substrate-dependent Pathway* (2002) (29)
- Stimulation via CD3-Ti but not CD2 induces rapid tyrosine phosphorylation of a 68-kDa protein in the human Jurkat T cell line. (1990) (28)
- Insulin-dependent Tyrosine Phosphorylation of the vav Proto-oncogene Product in Cells of Hematopoietic Origin (*) (1995) (28)
- Preparation and use of anti-phosphotyrosine antibodies to study structure and function of insulin receptor. (1991) (28)
- Activation of the Phosphatidylinositol 3-Kinase Serine Kinase by 1 FNa ’ (2001) (27)
- Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase* (2016) (26)
- Nerve Growth Factor Receptor TrkA, a New Receptor in Insulin Signaling Pathway in PC12 Cells* (2013) (26)
- Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis. (2010) (26)
- Phosphatidylcholine Transfer Protein Interacts with Thioesterase Superfamily Member 2 to Attenuate Insulin Signaling (2013) (25)
- Recombinant human müllerian inhibiting substance inhibits epidermal growth factor receptor tyrosine kinase. (1989) (25)
- Insulin receptor substrate 1 (IRS‐1) plays a unique role in normal epidermal physiology (2007) (25)
- Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice. (2007) (24)
- The Insulin Receptor Protein Kinase (1985) (24)
- Differential modulation of the tyrosine phosphorylation state of the insulin receptor by IRS (insulin receptor subunit) proteins. (1999) (23)
- Human insulin receptors expressed in insulin-insensitive mouse fibroblasts couple with extant cellular effector systems to confer insulin sensitivity and responsiveness. (1989) (23)
- Pertussis toxin inhibits autophosphorylation and activation of the insulin receptor kinase. (1991) (23)
- Insulin-like growth factor-1 induces rapid tyrosine phosphorylation of the vav proto-oncogene product. (1996) (23)
- Attenuation of Accumulation of Neointimal Lipid by Pioglitazone in Mice Genetically Deficient in Insulin Receptor Substrate-2 and Apolipoprotein E (2005) (22)
- Down-regulation of Insulin Receptor Substrate 1 during Hyperglycemia Induces Vascular Smooth Muscle Cell Dedifferentiation* (2016) (21)
- An Mr 180,000 protein is an endogenous substrate for the insulin-receptor-associated tyrosine kinase in human placenta. (1987) (21)
- Tyrosine-kinase defect of the insulin receptor in cultured fibroblasts from patients with lipoatropic diabetes. (1989) (21)
- Essential role of protein kinase Cζ in the impairment of insulin‐induced glucose transport in IRS‐2‐deficient brown adipocytes (2003) (21)
- Elevated circulating follistatin associates with an increased risk of type 2 diabetes (2021) (20)
- Coordinate Phosphorylation of Insulin-Receptor Kinase and Its 175,000-Mr Endogenous Substrate in Rat Hepatocytes (1991) (20)
- Hyperglycemia induces vascular smooth muscle cell dedifferentiation by suppressing insulin receptor substrate-1–mediated p53/KLF4 complex stabilization (2018) (19)
- THE MOLECULAR BASIS OF INSULIN ACTION (2007) (19)
- Models of insulin action on metabolic and growth response genes (1992) (19)
- Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis (2018) (18)
- Characterization of phorbol ester-stimulated serine phosphorylation of the human insulin receptor. (1994) (18)
- Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3β? (2010) (18)
- Differentiation-dependent phosphorylation of a 175,000 molecular weight protein in response to insulin and insulin-like growth factor-I in L6 skeletal muscle cells. (1989) (18)
- Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice. (2009) (18)
- Decreased autophosphorylation of EGF receptor in insulin-deficient diabetic rats. (1988) (18)
- Insulin stimulates tyrosine phosphorylation of its receptor beta-subunit in intact rat hepatocytes. (1987) (18)
- Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins. (1997) (17)
- Phosphorylation of Forkhead Protein FoxO1 at S253 Regulates Glucose Homeostasis in Mice. (2019) (17)
- The IRS2 Gly1057Asp variant is associated with human longevity. (2010) (17)
- Foxo1 in hepatic lipid metabolism (2010) (16)
- Metformin and insulin meet in a most atypical way. (2009) (16)
- Separate domains of the insulin receptor contain sites of autophosphorylation and tyrosine kinase activity. (1987) (16)
- Insulin receptor substrate‐2 is expressed in kidney epithelium and up‐regulated in diabetic nephropathy (2013) (15)
- Analysis of compensatory beta-cell response in mice with combined mutations of Insr and Irs2. (2007) (14)
- The Insulin Receptor Tyrosine Kinase (1990) (14)
- Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling. (2020) (13)
- Common and Distinct Elements in Insulin and PDGF Signaling a (1995) (13)
- Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma (2016) (11)
- Insulin action and type 2 diabetes: lessons from knockout mice: (1999) (11)
- Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and Is Controlled by p38a MAPK During Insulin (2013) (11)
- Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice. (2016) (10)
- Diabetes forum: Extreme makeover of pancreatic α-cells (2010) (10)
- The IRS.I signaling system (1994) (10)
- REGULATION OF INSULIN/IGF-1 SIGNALING BY PROTEASOME-MEDIATED DEGRADATION OF IRS-2 (2001) (10)
- Phosphatidylinositol 3 kinase is activated by insulin (1990) (10)
- Regulation of protein synthesis by insulin through IRS-1. (2001) (9)
- Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance (2020) (9)
- The Structure and Function of p55 Reveal a New Regulatory Subunit for Phosphatidylinositol 3-Kinase (1995) (8)
- A Specific Increased Expression of Insulin Receptor Substrate 2 in Pancreatic -Cell Lines Is Involved in Mediating Serum-Stimulated -Cell Growth (1998) (8)
- IRS1Ser³⁰⁷ phosphorylation does not mediate mTORC1-induced insulin resistance. (2014) (8)
- Pdx 1 restores β cell function in Irs 2 knockout mice (2002) (7)
- The role of receptor kinase activity and the NPEY960 motif in insulin-accelerated receptor-mediated insulin internalization. (1996) (7)
- Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice (2021) (7)
- Mechanisms of Insulin Action (2012) (7)
- The role of hepatokines in NAFLD. (2023) (7)
- Dysregulation of IRS-proteins causes insulin resistance and diabetes (2000) (6)
- FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance (2021) (6)
- Epidermal growth factor stimulated phosphorylation of a 120-kilodalton endogenous substrate protein in rat hepatocytes. (1990) (6)
- Phosphorylation of the solubilized insulin receptor by the gene product of the Rous sarcoma virus, pp60src (1984) (5)
- Chapter 33 – The Mechanisms of Insulin Action (2016) (5)
- IRS 2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease (2018) (5)
- Early biochemical events in insulin-stimulated fluid phase endocytosis. (1999) (5)
- Irs2 deficiency alters hippocampus-associated behaviors during young adulthood. (2021) (5)
- Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex (2022) (4)
- Irs 2 and Irs 4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis # (2014) (4)
- Purification and Partial Sequence Analysis of pp 185 , the Major Cellular Substrate of the Insulin Receptor Tyrosine Kinase * (2001) (4)
- Binding kinetics of mutated insulin receptors in transfected cells grown in suspension culture: application to the Tyr----Phe 960 insulin receptor mutant. (1989) (4)
- kNOXing on the door of selective insulin resistance. (2012) (4)
- The P300 acetyltransferase inhibitor C646 promotes membrane translocation of insulin receptor protein substrate and interaction with the insulin receptor (2022) (4)
- Breathing Room: The (Un)Natural History of Adipose Microhypoxia and Insulin Resistance (2009) (4)
- TAZ inhibits GR and coordinates hepatic glucose homeostasis in normal physiologic states (2020) (3)
- Deletion of Irs 2 Causes Reduced Kidney Size in Mice : Role for Inhibition of GSK 3 β ? (2010) (3)
- Abstract 3559: Insulin Receptor Substrates (IRS) Signaling are Essential Regulators of Mitochondrial Function and Cardiomyocyte Survival (2008) (3)
- Differential Regulation of Insulin Receptor Substrate-2 and Mitogen-Activated Protein Kinase Tyrosine Phosphorylation by Phosphatidylinositol 3-Kinase Inhibitors in SH-SY5Y Human Neuroblastoma Cells* * This work was supported by NIH Grants R29-NS-32843 and R01-NS-36778, grants from the American Diab (1998) (3)
- Abstract 3992: Insulin Receptor Substrates (IRS) are Critical Regulators of Autophagy and Cardiomyocyte Survival (2009) (3)
- TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states (2021) (3)
- Early biochemical events in insulin-stimulated fluid phase endocytosis. (1999) (3)
- Section 4 :-Cell Mass and Function in Type 2 Diabetes IRS Proteins and-Cell Function (2001) (3)
- Socs1 Induces Insulin Resistance by Promoting Ubiquitin-Mediated Degradation of IRS1 and IRS2 (2002) (2)
- Alterations in growth and apoptosis of IRS-1 deficient beta-cells (2005) (2)
- Activation of liver and muscle insulin receptor tyrosine kinase activity during in vivo insulin administration in rats (1990) (2)
- Receptor Tyrosine Kinases and the Insulin Signaling System (2017) (2)
- 284 UROTHELIUM-RELEASED ATP CONTRIBUTES TO BLADDER DYSFUNCTION IN TYPE 2 DIABETES (2013) (2)
- Erratum: Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth (Journal of Clinical Investigation (2006) 116 (101-114) DOI: 10.1172/JCI25735) (2006) (1)
- 282-LB: Dysregulated FGF21 Links Hepatic Insulin Resistance to Dysfunctional BAT (2019) (1)
- Correction for Long et al., “Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways” (2017) (1)
- Longevity: Mapping the path to a longer life (2015) (1)
- Transcription Factor FoxO1 Mediates the Survival of Photoreceptors (2006) (1)
- Inhibition of insulin signaling by protein kinase C (2011) (1)
- Mechanism of Insulin Action (2016) (1)
- Disruptionof IRS-2 causes type 2 diabetes inmice (1998) (1)
- Publisher Correction: Inactivating hepatic follistatin alleviates hyperglycemia (2018) (1)
- Body image as a visuomotor transformation device revealed in adaptation to reversed vision (1)
- IRS-Protein Scaffolds and Insulin/IGF Action in Central and Peripheral Tissues (2010) (1)
- Serine Phosphorylation Sites on IRS2 by Angiotensin II and PKC Activated to Induce 1 (2013) (1)
- Insulin-Stimulated Phosphorylation of IRS-1 on Ser302 Correlates with Enhanced Insulin Signaling (2004) (1)
- IRS-2 is a Common Element in Peripheral Insulin Signaling and β-Cell Function (2000) (1)
- 1375 BLADDER DYSFUNCTION ASSOCIATED WITH TYPE 2 DIABETES IS IMPROVED BY INHIBITION OF INFLAMMATORY AND APOPTOTIC MEDIATORS (2011) (0)
- 500 COMBINATION OF METFORMIN AND INHIBITION OF TNF-A REVERSE THE BLADDER DYSFUNCTION ASSOCIATED WITH TYPE 2 DIABETES (2012) (0)
- Tumorigenesis and Neoplastic Progression Irs 2 Inactivation Suppresses Tumor Progression in Pten / Mice (2010) (0)
- Molecular Mechanisms of Signal Transduction by Tyrosine Kinase Receptors (1993) (0)
- Modulateurs de l'irs (2003) (0)
- Insulin signaling in combination with reduced glucocorticoid activity attenuate post-prandial gene expression in liver (2018) (0)
- Inactivating hepatic follistatin alleviates hyperglycemia (2018) (0)
- Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance (2020) (0)
- Copper restoration by liver Ceruloplasmin ablation ameliorates NAFLD via SCO1-AMPK-LKB1 complex (2021) (0)
- Translational control at the mRNA-binding step (1997) (0)
- multisite phosphorylation of IRS-1. Pleiotropic insulin signals are engaged by (2013) (0)
- 1835-P: Deletion of Insulin Receptor Substrate 2 in AGRP Neurons Causes Beta-Cell Dysfunction (2019) (0)
- Author response: TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states (2021) (0)
- O-32: p55PIK is expressed and required during neuronal differentiation (2009) (0)
- MP17-14 CORRECTION OF HYPERGLYCEMIA AND HYPERINSULINEMIA BY GENETIC MODIFICATION RESTORES BLADDER DYSFUNCTION ASSOCIATED WITH TYPE 2 DIABETES (2014) (0)
- P-2: Insulin and food intake increase neuronal phosphotyrosine levels in the arcuate nucleus of the rat hypothalamus (2009) (0)
- JNK Works as a Negative Feedback Inhibitor of Insulin Action (2002) (0)
- IRS1Ser307 PHOSPHORYLATION DOES NOT MEDIATE mTORC1- INDUCED INSULIN RESISTANCE (2014) (0)
- O-25: Purification and cloning of IRS-2 reveals the molecular bases of IRS-proteins in insulin and cytokine signaling (2009) (0)
- O-43: Multiple pathways for insulin-induced egr-1 expression (2009) (0)
- O-27: IRS-2 binds to the insulin receptor through its PTB domain and through a newly identified domain comprising amino acids 591 to 786 (2009) (0)
- Rapid internalization of the insulin receptor in rat hepatoma cells (1987) (0)
- Metabolic Dysfunction within Brown Adipose Tissue and Skeletal Muscle Caused by Complete Hepatic Insulin Resistance Is Reversible by FGF-21 Treatment (2018) (0)
- Circulating follistatin predicts type 2 diabetes risk (2020) (0)
- O-47: Mechanisms of TNF-α induced insulin resistance (2009) (0)
- Potentiation in Hippocampal CA1 Pyramidal Neurons Caffeine-Mediated Presynaptic Long-Term (2015) (0)
- Phosphatidylinositol pathways in growth and transformation (1990) (0)
- has no effect on glycogen synthase activity Overexpression or ablation of JNK in skeletal muscle (2005) (0)
- MetastasisPromotes Mammary Tumor Suppression of Insulin Receptor Substrate (2014) (0)
- How insulin works - Shedding some light into the black box (1989) (0)
- Impairment of insulin-stimulated glucose utilization is associated with burn-induced insulin resistance in mouse muscle by hyperinsulinemic-isoglycemic clamp (2020) (0)
- Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity (2017) (0)
- Insulin Receptor Substrate-2 in (cid:1) -Cells Decreases Diabetes in Nonobese Diabetic Mice (2009) (0)
- Foxo1-Ser253 Phosphorylation Regulates Glucose Homeostasis in Mice (2018) (0)
- Function of the Insulin Receptor Kinase in the Intact Cell (2018) (0)
- 442 A GENETIC ANIMAL MODEL FOR BLADDER DYSFUNCTION ASSOCIATED WITH TYPE 2 DIABETES (2010) (0)
- O-28: Characterization of IRS-1 molecules containing single SH2-protein binding determinants (2009) (0)
- Cyclins D2 and D1 Are Essential for Postnatal Pancreatic (cid:2) -Cell Growth (2005) (0)
- Insulin-Stimulat ed OocyteMaturation Requires Insulin Receptor Substrate 1andInteraction withtheSH2Domains ofPhosphatidylinositol 3-Kinase (1993) (0)
- Abstract 177: Insulin Resistance and Mechanisms of Heart Failure (2013) (0)
- CHAPTER 72 – IRS-Protein Scaffolds and Insulin/IGF Action (2003) (0)
- Regulation of Metabolism and Reproduction Through the Insulin Receptor Substrate Protein Signaling System (2002) (0)
- IRS-2 failure causes multisystem pathophysiology (2001) (0)
- P-49: Interaction of IRS molecules with a novel 19 kD protein that carries an armadillo motif (2009) (0)
- The Relationship Between the Insulin Receptor Substrates and Metabolic Disease (2008) (0)
- O-42: Mitogenic signalling by insulin in a T-cell lymphoma, the LB cell line, devoid of IGF-I receptors: evidence for the lack of involvement of the RAS-MAP kinase pathway and for a possibly novel IRS-like molecule (2009) (0)
- Fasting Blood Glucose Concentration at 6 and 8 wk of Age in Either WT, Gsk-3β+/−, Irs2−/−, or Gsk-3β+/−Irs2−/− Mice (2008) (0)
- Erratum. Inhibition of TNF-α Improves the Bladder Dysfunction That Is Associated With Type 2 Diabetes. Diabetes 2012;61:2134–2145 (2021) (0)
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