Melvin I. Simon

Q: What Schools Are Affiliated With Melvin I. Simon

Melvin I. Simon is affiliated with the following schools: California Institute of Technology, University of Regensburg, University of California, San Diego, Free University of Berlin, University of Barcelona, University of Texas Southwestern Medical Center, University of Cambridge, Heidelberg University

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Melvin I. Simon

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Melvin I. Simon

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Molecular Biology

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#358

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#435

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Chemistry
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Melvin I. Simon's Degrees

Bachelors Chemistry California Institute of Technology

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Melvin I. Simon's Published Works

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Published Works

Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector. (1992) (1633)
The DNA sequence of human chromosome 22 (1999) (1117)
Robust perfect adaptation in bacterial chemotaxis through integral feedback control. (2000) (1033)
Flagellar rotation and the mechanism of bacterial motility (1974) (686)
Macromolecular Crystallography: Part A (1997) (664)
A Diverse Family of GPCRs Expressed in Specific Subsets of Nociceptive Sensory Neurons (2001) (597)
The genome of Nanoarchaeum equitans: Insights into early archaeal evolution and derived parasitism (2003) (528)
Phosphorylation of three proteins in the signaling pathway of bacterial chemotaxis (1988) (515)
Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1 (2000) (511)
Signal transduction pathways involving protein phosphorylation in prokaryotes. (1991) (485)
Gα15 and Gα16 Couple a Wide Variety of Receptors to Phospholipase C (*) (1995) (468)
Subunits βγ of heterotrimeric G protein activate β2 isoform of phospholipase C (1992) (460)
Structure of CheA, a Signal-Transducing Histidine Kinase (1999) (459)
Construction and characterization of a human bacterial artificial chromosome library. (1996) (433)
Homologies between signal transducing G proteins and ras gene products. (1984) (410)
TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms (2009) (398)
Activation of G12/G13 Results in Shape Change and Rho/Rho-Kinase–mediated Myosin Light Chain Phosphorylation in Mouse Platelets (1999) (380)
Repetitive segmental structure of the transducin beta subunit: homology with the CDC4 gene and identification of related mRNAs. (1986) (357)
Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. (1999) (326)
Prolonged photoresponses in transgenic mouse rods lacking arrestin (1997) (324)
A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression (2006) (322)
Histidine phosphorylation and phosphoryl group transfer in bacterial chemotaxis (1988) (299)
The entry of diphtheria toxin into the mammalian cell cytoplasm: evidence for lysosomal involvement (1980) (291)
Recombinational switch for gene expression. (1977) (290)
Transmembrane signal transduction in bacterial chemotaxis involves ligand-dependent activation of phosphate group transfer. (1989) (285)
Evolution and organization of the fibrinogen locus on chromosome 4: gene duplication accompanied by transposition and inversion. (1985) (279)
Stable propagation of cosmid sized human DNA inserts in an F factor based vector. (1992) (273)
Activation of phospholipase C by the alpha subunits of the Gq and G11 proteins in transfected Cos-7 cells. (1992) (272)
RGS9 Modulates Dopamine Signaling in the Basal Ganglia (2003) (270)
Activation of phospholipase C by alpha 1-adrenergic receptors is mediated by the alpha subunits of Gq family. (1992) (269)
Rapid and Reproducible Deactivation of Rhodopsin Requires Multiple Phosphorylation Sites (2000) (260)
G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma. (1992) (258)
Conserved aspartate residues and phosphorylation in signal transduction by the chemotaxis protein CheY. (1990) (258)
Characterization of G-protein alpha subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines. (1991) (257)
Antibodies to the αq subfamily of guanine nucleotide-binding regulatory protein α subunits attenuate activation of phosphatidylinositol 4,5-bisphosphate hydrolysis by hormones (1991) (243)
Evidence for two apoptotic pathways in light-induced retinal degeneration (2002) (242)
Protein histidine kinases and signal transduction in prokaryotes and eukaryotes. (1994) (239)
Gz, a guanine nucleotide-binding protein with unique biochemical properties. (1990) (235)
Transposition of structural genes to an expression sequence on a linear plasmid causes antigenic variation in the bacterium Borrelia hermsii (1985) (235)
Host protein requirements for in vitro site-specific DNA inversion (1986) (234)
Assembly and function of a quaternary signal transduction complex monitored by surface plasmon resonance (1993) (233)
A fifth member of the mammalian G-protein beta-subunit family. Expression in brain and activation of the beta 2 isotype of phospholipase C. (1994) (232)
Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier (2013) (231)
G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells. (1991) (229)
Hyphal development in Neurospora crassa: involvement of a two-component histidine kinase. (1996) (229)
Evolution of the mammalian G protein α subunit multigene family (1992) (229)
Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase. (1994) (229)
Measurement by quantitative PCR of changes in HPRT, PGK-1, PGK-2, APRT, MTase, and Zfy gene transcripts during mouse spermatogenesis. (1990) (226)
G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits. (1991) (224)
Defective platelet activation in Gαq-deficient mice (1997) (224)
Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits. (1993) (224)
bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations. (1996) (224)
Regulation of lateral flagella gene transcription in Vibrio parahaemolyticus (1986) (222)
Diphtheria toxin forms transmembrane channels in planar lipid bilayers. (1981) (217)
Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum (2002) (217)
Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin. (1988) (215)
Computer simulation of the phosphorylation cascade controlling bacterial chemotaxis. (1993) (212)
Defective platelet activation in G alpha(q)-deficient mice. (1997) (212)
Specific interactions of chemoattractant factor receptors with G-proteins. (1993) (211)
The photodynamic reaction of methylene blue with deoxyribonucleic acid. (1962) (211)
NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain (2010) (207)
Primary structure of the M subunit of the reaction center from Rhodopseudomonas sphaeroides. (1983) (199)
Suppression of LPS-Induced TNF-α Production in Macrophages by cAMP Is Mediated by PKA-AKAP95-p105 (2009) (192)
A quantitative characterization of the yeast heterotrimeric G protein cycle (2003) (188)
Regulation by cAMP-dependent protein kinease of a G-protein-mediated phospholipase C (1996) (184)
Instability of GGL domain-containing RGS proteins in mice lacking the G protein β-subunit Gβ5 (2003) (183)
Increased susceptibility to light damage in an arrestin knockout mouse model of Oguchi disease (stationary night blindness) (1999) (180)
Phospholipase Cβ 3 Mediates the Scratching Response Activated by the Histamine H1 Receptor on C-Fiber Nociceptive Neurons (2006) (180)
Sensory transducers of E. coli are composed of discrete structural and functional domains (1983) (179)
Protein phosphorylation is involved in bacterial chemotaxis. (1987) (179)
Histidine and aspartate phosphorylation: two-component systems and the limits of homology. (1994) (178)
D2 Dopamine Receptors Colocalize Regulator of G-Protein Signaling 9-2 (RGS9-2) via the RGS9 DEP Domain, and RGS9 Knock-Out Mice Develop Dyskinesias Associated with Dopamine Pathways (2005) (178)
Identification of critical regions on phospholipase C-beta 1 required for activation by G-proteins. (1993) (175)
Analysis of the nucleotide sequence of an invertible controlling element. (1980) (174)
Mutations in a C. elegans Gqα Gene Disrupt Movement, Egg Laying, and Viability (1996) (173)
Phase variation in Salmonella: genetic analysis of a recombinational switch. (1979) (171)
Bacterial bioluminescence: isolation and expression of the luciferase genes from Vibrio harveyi. (1982) (171)
Hin-mediated site-specific recombination requires two 26 by recombination sites and a 60 by recombinational enhancer (1985) (170)
Phase variation: Genetic analysis of switching mutants (1980) (169)
Phase variation: evolution of a controlling element. (1980) (168)
Antigenic variation is associated with DNA rearrangements in a relapsing fever borrelia (1985) (167)
Tissue-specific and developmental regulation of rod opsin chimeric genes in transgenic mice (1991) (167)
Recoverin Regulates Light-dependent Phosphodiesterase Activity in Retinal Rods (2004) (166)
The dynamics of protein phosphorylation in bacterial chemotaxis (1990) (166)
Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Gαq/11 pathway (2002) (165)
Attenuation of sensory receptor signaling by covalent modification. (1992) (164)
Retinal degeneration is rescued in transgenic rd mice by expression of the cGMP phosphodiesterase beta subunit. (1992) (163)
Characterization of Escherichia coli Flagellar Mutants That are Insensitive to Catabolite Repression (1974) (156)
Genomic Characterization of the Human Heterotrimeric G Protein α, β, and γ Subunit Genes (2000) (155)
Measuring gene expression with light. (1985) (154)
Nucleotide binding by the histidine kinase CheA (2001) (153)
Pertussis Toxin-sensitive Activation of Phospholipase C by the C5a and fMet-Leu-Phe Receptors* (1996) (151)
Roles of phospholipase C beta2 in chemoattractant-elicited responses. (1997) (147)
G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C. (1995) (147)
Isolation and characterization of a cDNA clone for the gamma subunit of bovine retinal transducin. (1984) (145)
The response regulators CheB and CheY exhibit competitive binding to the kinase CheA. (1995) (142)
Structure of the serine chemoreceptor in Escherichia coli (1983) (141)
A Novel Form of the G Protein β Subunit Gβ5 Is Specifically Expressed in the Vertebrate Retina* (1996) (137)
COS1, a two-component histidine kinase that is involved in hyphal development in the opportunistic pathogen Candida albicans. (1998) (136)
Distinct forms of the beta subunit of GTP-binding regulatory proteins identified by molecular cloning. (1987) (135)
Nucleotide sequence of the luxA gene of Vibrio harveyi and the complete amino acid sequence of the alpha subunit of bacterial luciferase. (1986) (134)
Chromosomal sublocalization of human c-myb and c-fes cellular onc genes (1983) (133)
Diversity of the G-protein family: Sequences from five additional α subunits in the mouse (1989) (130)
Chimeric chemosensory transducers of Escherichia coli. (1985) (129)
Protein phosphorylation in chemotaxis and two-component regulatory systems of bacteria. (1989) (128)
Chemotaxis in Escherichia coli: methylation of che gene products. (1977) (128)
New unified nomenclature for the flagellar genes of Escherichia coli and Salmonella typhimurium. (1988) (127)
RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. (1996) (126)
Overview of the Alliance for Cellular Signaling (2002) (125)
PRR5L degradation promotes MTORC2-mediated PKCδ phosphorylation and cell migration downstream of Gα12 (2012) (125)
Isolation of the gene encoding the Hin recombinational enhancer binding protein. (1988) (124)
Mice Lacking G-Protein Receptor Kinase 1 Have Profoundly Slowed Recovery of Cone-Driven Retinal Responses (2000) (122)
Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein Go. (1990) (122)
Optimized conditions for pulsed field gel electrophoretic separations of DNA. (1988) (117)
Transcriptional regulatory regions of testis-specific PGK2 defined in transgenic mice. (1989) (117)
A G protein gamma subunit shares homology with ras proteins. (1989) (117)
Pulsed field gel electrophoresis. (1989) (116)
Phospholipase C β4 is involved in modulating the visual response in mice (1996) (112)
Surface-enhanced Raman Scattering (SERS) method and instrumentation for genomics and biomedical analysis (1999) (108)
Expression of CheA fragments which define domains encoding kinase, phosphotransfer, and CheY binding activities. (1993) (108)
Light-Dependent Translocation of Arrestin in the Absence of Rhodopsin Phosphorylation and Transducin Signaling (2003) (106)
THE DYE-SENSITIZED PHOTOOXIDATION OF PURINE AND PYRIMIDINE DERIVATIVES. (1964) (102)
Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis (2013) (102)
Regulation of gene expression by site-specific inversion (1978) (101)
Thrombin Protease-activated Receptor-1 Signals through Gq- and G13-initiated MAPK Cascades Regulating c-Jun Expression to Induce Cell Transformation* (2003) (100)
Instability of GGL domain-containing RGS proteins in mice lacking the G protein beta-subunit Gbeta5. (2003) (100)
Nucleotide sequence corresponding to five chemotaxis genes in Escherichia coli (1986) (99)
Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. (2000) (99)
G protein diversity is increased by associations with a variety of gamma subunits. (1990) (99)
The G alpha q and G alpha 11 proteins couple the thyrotropin-releasing hormone receptor to phospholipase C in GH3 rat pituitary cells. (1992) (98)
Chromosomal mapping of the mink cell focus-inducing and xenotropic env gene family in the mouse. (1983) (98)
Synthesis of a sequence-specific DNA-cleaving peptide. (1987) (95)
G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells. (1996) (95)
Caenorhabditis elegans Galphaq regulates egg-laying behavior via a PLCbeta-independent and serotonin-dependent signaling pathway and likely functions both in the nervous system and in muscle. (2003) (94)
Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice. (1998) (94)
Co-expression of Gβ5 Enhances the Function of Two Gγ Subunit-like Domain-containing Regulators of G Protein Signaling Proteins* (2000) (93)
The solution structure and interactions of CheW from Thermotoga maritima (2002) (90)
Developmental regulation of expression of the lactate dehydrogenase (LDH) multigene family during mouse spermatogenesis. (1990) (89)
Prolonged Photoresponses and Defective Adaptation in Rods of Gβ5-/- Mice (2003) (88)
Flagellar Assembly Mutants in Escherichia coli (1972) (88)
Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons (2011) (87)
RGS9-1 is required for normal inactivation of mouse cone phototransduction. (2001) (85)
Identification of an alternative Gαq-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes (2007) (84)
Localization of proteins controlling motility and chemotaxis in Escherichia coli (1977) (84)
Identification of polypeptides necessary for chemotaxis in Escherichia coli (1977) (83)
Modules in the Photoreceptor RGS9-1·Gβ 5L GTPase-accelerating Protein Complex Control Effector Coupling, GTPase Acceleration, Protein Folding, and Stability* (2000) (83)
Molecular Mechanism of the Inhibition of Phospholipase C β3 by Protein Kinase C* (2000) (82)
Activation of the phosphosignaling protein CheY. II. Analysis of activated mutants by 19F NMR and protein engineering. (1993) (81)
The carboxy-terminal portion of the CheA kinase mediates regulation of autophosphorylation by transducer and CheW (1993) (81)
Fis binding to the recombinational enhancer of the Hin DNA inversion system. (1987) (80)
Evolution of the mammalian G protein alpha subunit multigene family. (1992) (79)
Mutations in a C. elegans Gqalpha gene disrupt movement, egg laying, and viability. (1996) (78)
Diversity among the beta subunits of heterotrimeric GTP-binding proteins: characterization of a novel beta-subunit cDNA. (1992) (78)
Crystal structures of CheY from Thermotoga maritima do not support conventional explanations for the structural basis of enhanced thermostability (1998) (76)
Determining transcript number using the polymerase chain reaction: Pgk-2, mP2, and PGK-2 transgene mRNA levels during spermatogenesis. (1991) (76)
Mutants defective in bacterial chemotaxis show modified protein phosphorylation (1988) (75)
Constitutively Active Gαq and Gα13 Trigger Apoptosis through Different Pathways* (1997) (74)
Chemotactic control of the two flagellar systems of Vibrio parahaemolyticus (1990) (74)
NMR studies of the phosphotransfer domain of the histidine kinase CheA from Escherichia coli: assignments, secondary structure, general fold, and backbone dynamics. (1995) (74)
Genetic Analysis of Flagellar Mutants in Escherichia coli (1973) (72)
High-resolution restriction maps of bacterial artificial chromosomes constructed by optical mapping. (1998) (70)
Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits. (1993) (70)
Differential gene expression during mouse spermatogenesis. (1989) (69)
Multiple regions of G alpha 16 contribute to the specificity of activation by the C5a receptor. (1995) (69)
Phosphorylation assays for proteins of the two-component regulatory system controlling chemotaxis in Escherichia coli. (1991) (67)
Purification and Thermal Stability of Intact Bacillus subtilis Flagella (1971) (67)
In different organisms, the mode of interaction between two signaling proteins is not necessarily conserved. (2004) (66)
Transposon mutagenesis of marine Vibrio spp (1984) (66)
Interaction of Gα12 with Gα13 and Gαq signaling pathways (2002) (66)
Spatial relationship of the Fis binding sites for Hin recombinational enhancer activity (1987) (66)
Primary structure of the L subunit of the reaction center from Rhodopseudomonas sphaeroides. (1984) (65)
Gαi2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation (2007) (65)
Human genome anatomy: BACs integrating the genetic and cytogenetic maps for bridging genome and biomedicine. (1999) (64)
Analysis of the Major Patterns of B Cell Gene Expression Changes in Response to Short-Term Stimulation with 33 Single Ligands1 (2004) (64)
A fosmid-based genomic map and identification of 474 genes of the hyperthermophilic archaeonPyrobaculum aerophilum (1997) (64)
Direct genetic demonstration of G alpha 13 coupling to the orphan G protein-coupled receptor G2A leading to RhoA-dependent actin rearrangement. (2000) (62)
Sensory transducers of E. coli are encoded by homologous genes (1981) (61)
The identification of the mot gene product with Escherichia coli-lambda hybrids. (1976) (61)
A versatile approach to multiple gene RNA interference using microRNA-based short hairpin RNAs (2007) (61)
Organization of transmembrane signalling by heterotrimeric G proteins. (1996) (61)
Activation of the phosphosignaling protein CheY. I. Analysis of the phosphorylated conformation by 19F NMR and protein engineering. (1993) (59)
The human blue opsin promoter directs transgene expression in short-wave cones and bipolar cells in the mouse retina. (1994) (59)
Importance of minor-groove contacts for recognition of DNA by the binding domain of Hin recombinase. (1990) (58)
Deactivation of Phosphorylated and Nonphosphorylated Rhodopsin by Arrestin Splice Variants (2006) (57)
DNA sequence adjacent to flagellar genes and evolution of flagellar-phase variation (1983) (57)
Cloning of the Vibrio harveyi luciferase genes: use of a synthetic oligonucleotide probe. (1983) (56)
Genetic analysis of mammalian G-protein signalling (1998) (56)
Insertion of diphtheria toxin into and across membranes: role of phosphoinositide asymmetry (1982) (56)
Complete nucleotide sequence of two generations of a bacterial artificial chromosome cloning vector. (1997) (55)
Novel Form of Adaptation in Mouse Retinal Rods Speeds Recovery of Phototransduction (2003) (55)
Operon controlling motility and chemotaxis in E. coli (1976) (55)
Archaeal ubiquity. (1996) (54)
Synthesis of mot and che gene products of Escherichia coli programmed by hybrid ColE1 plasmids in minicells (1977) (54)
Retarding photoreceptor degeneration in Pdegtm1/Pdegtml mice by an apoptosis suppressor gene. (1997) (54)
Division Mutants of Bacillus subtilis: Isolation and PBS1 Transduction of Division-Specific Markers (1971) (54)
Molecular architecture of Gαo and the structural basis for RGS16-mediated deactivation (2008) (53)
Functional Analysis of a Dominant Negative Mutant of Gαi2(*) (1995) (52)
Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. (1993) (52)
Flagellar-phase variation: isolation of the rh1 gene (1979) (52)
Group I Metabotropic Glutamate Receptor Signaling via Gαq/Gα11 Secures the Induction of Long-Term Potentiation in the Hippocampal Area CA1 (2002) (52)
The 35- and 36-kDa beta subunits of GTP-binding regulatory proteins are products of separate genes. (1988) (51)
The Ca2+-dependent Binding of Calmodulin to an N-terminal Motif of the Heterotrimeric G Protein β Subunit* (1997) (50)
Deciphering Signaling Outcomes from a System of Complex Networks (2009) (50)
Protein phosphorylation and bacterial chemotaxis. (1988) (50)
A bacterial artificial chromosome-based framework contig map of human chromosome 22q. (1996) (50)
Analysis of C5a-mediated chemotaxis by lentiviral delivery of small interfering RNA. (2004) (49)
Localization of the human myelin basic protein gene (MBP) to region 18q22----qter by in situ hybridization. (1985) (49)
Synthesis of a site-specific DNA-binding peptide. (1987) (49)
Genetic Analysis of Bacteriophage Mu-Induced Flagellar Mutants in Escherichia coli (1973) (48)
DNA-binding properties of the Hin recombinase. (1989) (47)
Analysis of the 1.1-Mb Human α/δ T-Cell Receptor Locus with Bacterial Artificial Chromosome Clones (1997) (47)
Silencing the expression of multiple Gbeta-subunits eliminates signaling mediated by all four families of G proteins. (2005) (47)
COS-l, a putative two-component histidine kinase of Candida albicans, is an in vivo virulence factor. (2001) (46)
Selective Inhibition of Human α-Thrombin by Cobalt(III) Schiff Base Complexes (1998) (46)
Phosphotransfer and CheY-binding domains of the histidine autokinase CheA are joined by a flexible linker. (1996) (45)
Expression of flagellar genes carried by bacteriophage lambda (1976) (44)
Synergistic Ca2+ Responses by Gαi- and Gαq-coupled G-protein-coupled Receptors Require a Single PLCβ Isoform That Is Sensitive to Both Gβγ and Gαq* (2010) (44)
Mutations in the chemotactic response regulator, CheY, that confer resistance to the phosphatase activity of CheZ (1995) (42)
Signaling and Cross-talk by C5a and UDP in Macrophages Selectively Use PLCβ3 to Regulate Intracellular Free Calcium* (2008) (41)
Analysis of the functional components of the phase variation system. (1981) (41)
Genes for the hook-basal body proteins of the flagellar apparatus in Escherichia coli (1978) (41)
CHAPTER 12 – Phase Variation and Related Systems (1983) (40)
BAC and PAC contigs covering 3.5 Mb of the Down syndrome congenital heart disease region between D21S55 and MX1 on chromosome 21. (1997) (40)
The Retinal Specific Protein RGS-r Competes with the γ Subunit of cGMP Phosphodiesterase for the α Subunit of Transducin and Facilitates Signal Termination* (1997) (40)
Synergistic effect of Bcl-2 and BAG-1 on the prevention of photoreceptor cell death. (2000) (40)
Phase variation in Salmonella: analysis of Hin recombinase and hix recombination site interaction in vivo. (1988) (40)
Thermostable chemotaxis proteins from the hyperthermophilic bacterium Thermotoga maritima (1996) (39)
Downregulation of cGMP phosphodiesterase induced by expression of GTPase-deficient cone transducin in mouse rod photoreceptors. (1994) (38)
Localized perturbations in CheY structure monitored by NMR identify a CheA binding interface (1995) (38)
Requirements for the translocation of diphtheria toxin fragment A across lipid membranes. (1985) (38)
Helical shifts generate two distinct conformers in the atomic resolution structure of the CheA phosphotransferase domain from Thermotoga maritima. (2004) (37)
Structural and Chemical Requirements for Histidine Phosphorylation by the Chemotaxis Kinase CheA* (2005) (37)
Diphtheria toxin has the properties of a lectin. (1978) (36)
Interferon induction: DNA-RNA hybrid or double stranded RNA? (1971) (36)
Synthesis of Bacterial Flagella II. PBSl Transduction of Flagella-specific Markers in Bacillus subtilis (1969) (36)
Purification and Partial Characterization of Bacillus subtilis Flagellar Hooks (1971) (35)
Identification of the structural gene for the hook subunit protein of Escherichia coli flagella (1978) (35)
Characterization of Escherichia coli chemotaxis receptor mutants with null phenotypes (1986) (35)
Pulsed field gel electrophoresis techniques for separating 1- to 50-kilobase DNA fragments. (1989) (35)
Expression of rhodopsin promoter transgene product in both rods and cones. (1994) (35)
Phospholipase C beta 4 is involved in modulating the visual response in mice. (1996) (34)
PHOTOSENSITIZED REACTION OF POLYRIBONUCLEOTIDES. I. EFFECTS ON THEIR SUSCEPTIBILITY TO ENZYME DIGESTION AND THEIR ABILITY TO ACT AS SYNTHETIC MESSENGERS. (1965) (33)
Characterization of a Goα Mutant That Binds Xanthine Nucleotides* (1997) (33)
Coupling of receptor function to phosphate-transfer reactions in bacterial chemotaxis. (1991) (33)
Cloning of the C-terminal cytoplasmic fragment of the tar protein and effects of the fragment on chemotaxis of Escherichia coli (1988) (33)
Molecular mechanism of the inhibition of phospholipase C beta 3 by protein kinase C. (2000) (33)
Cloning multigene families with degenerate PCR primers (1991) (31)
Neurobiology of Disease D 2 Dopamine Receptors Colocalize Regulator of G-Protein Signaling 9-2 ( RGS 9-2 ) via the RGS 9 DEP Domain , and RGS 9 Knock-Out Mice Develop Dyskinesias Associated with Dopamine Pathways (2005) (31)
In vivo and in vitro characterization of Escherichia coli protein CheZ gain- and loss-of-function mutants (1996) (31)
In vitro analysis of Hin-mediated site-specific recombination. (1984) (31)
Phase variation and the Hin protein: in vivo activity measurements, protein overproduction, and purification (1984) (30)
Chromosomal mapping of murine c-fes and c-src genes (1984) (30)
Mutational analysis of G protein α subunit Goα expressed in Escherichia coli (1993) (30)
Gαq-containing G proteins regulate B cell selection and survival and are required to prevent B cell–dependent autoimmunity (2010) (29)
Identification of small molecule antagonists of the human mas-related gene-X1 receptor. (2006) (29)
Variability in G-protein-coupled signaling studied with microfluidic devices. (2010) (29)
Genetic Control of Bacterial Adhesion (1984) (28)
Characterization of lambda Escherichia coli hybrids carrying chemotaxis genes (1977) (28)
Orientation of the putative recognition helix in the DNA-binding domain of Hin recombinase complexed with the hix site. (1990) (28)
Structure of the bovine transducin gamma subunit gene and analysis of promoter function in transgenic mice. (1993) (28)
Enhancers of site-specific recombination in bacteria (1987) (27)
Gene expression profiles of light-induced apoptosis in arrestin/rhodopsin kinase-deficient mouse retinas (2001) (27)
Irreversible enzymatic inhibition by cobalt chelate complexes (1995) (27)
Signal Transduction: Bringing the eukaryotes up to speed (1994) (27)
Comparative analysis of transcriptional profiles between two apoptotic pathways of light-induced retinal degeneration (2004) (26)
Inhibition of Subsets of G Protein-coupled Receptors by Empty Mutants of G Protein α Subunits in Go, G11, and G16 * (2000) (26)
Positioning Flagellar Genes in Escherichia coli by Deletion Analysis (1974) (26)
Isolation and in Vitro Characterization of CheZ Suppressors for the Escherichia coli Chemotactic Response Regulator Mutant CheYN23D (*) (1996) (26)
Classification of Bacillus subtilis flagellins (1977) (25)
Interaction of the Xanthine Nucleotide Binding Goα Mutant with G Protein-coupled Receptors* (1998) (25)
The regulation of flagellar formation and function. (1974) (24)
A segment of the C-terminal half of the G-protein beta 1 subunit specifies its interaction with the gamma 1 subunit. (1995) (24)
G 13 is an essential mediator of platelet activation in hemostasis and thrombosis (24)
Hao, W. et al. Evidence for two apoptotic pathways in light-induced retinal degeneration. Nat. Genet. 32, 254-260 (2002) (24)
Two-component signaling systems (2007) (23)
Characterization of a porin from the outer membrane of Vibrio anguillarum (1996) (22)
Genetic analysis of Escherichia coli K-12 region I flagellar mutants (1977) (22)
Recombinational Regulation of Gene Expression in Bacteria (1983) (22)
Phosphorylation and regulation of G-protein beta-gamma-activated phospholipase C-beta-2 by cAMP-dependent protein kinase (1996) (22)
Uncoupled Phosphorylation and Activation in Bacterial Chemotaxis (1997) (21)
Fluorescence-based sequencing directly from bacterial and P1-derived artificial chromosomes. (1997) (21)
The role of negative supercoiling in Hin-mediated site-specific recombination. (1992) (21)
Methacholine-induced airway hyperresponsiveness is dependent on Gαq signaling (2003) (20)
Intracellular signaling and the origins of the sensations of itch and pain. (2011) (20)
Polarity Exchange at the Interface of Regulators of G Protein Signaling with G Protein α-Subunits* (2000) (20)
A third P-domain peptide gene (TFF3), human intestinal trefoil factor, maps to 21q22.3. (1996) (20)
Mapping and gene order of U1 small nuclear RNA, endogenous viralenv sequence, amylase, and alcohol dehydrogenase-3 on mouse chromosome 3 (1988) (18)
Desensitization of Inositol 1,4,5-Trisphosphate/Ca2+-induced Cl− Currents by Prolonged Activation of G Proteins in Xenopus Oocytes* (1996) (18)
A 12-Mb complete coverage BAC contig map in human chromosome 16p13.1-p11.2. (1999) (18)
Bacterial flagella. (1977) (18)
Structure and Function of CheA, the Histidine Kinase Central to Bacterial Chemotaxis (2003) (18)
The retinal specific protein RGS-r competes with the gamma subunit of cGMP phosphodiesterase for the alpha subunit of transducin and facilitates signal termination. (1997) (18)
Dual Ligand Stimulation of RAW 264.7 Cells Uncovers Feedback Mechanisms That Regulate TLR-Mediated Gene Expression123 (2006) (18)
The transforming activity of activated G alpha 12. (1993) (17)
Antigenic Nature of Bacterial Flagellar Hook Structures (1970) (17)
Cloning and expression of the flagellar hook gene on hybrid plasmids in minicells (1977) (16)
Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse. (1989) (16)
Characterization of a human chromosome 22 enriched bacterial artificial chromosome sublibrary. (1995) (16)
Synthesis of Bacterial Flagella I. Requirement for Protein and Ribonucleic Acid Synthesis During Flagellar Regeneration in Bacillus subtilis (1968) (16)
The Alliance for Cellular Signaling Plasmid Collection (2007) (16)
Gq signaling is required for allergen-induced pulmonary eosinophilia. (2002) (14)
CA-repeat polymorphism at the D22S430 locus adjacent to NF2. (1993) (14)
Framework for a physical map of the human 22q13 region using bacterial artificial chromosomes (BACs). (1996) (14)
Genetic analysis of the mechanism of the salmonella phase variation site specific recombination system (2004) (14)
Construction and utility of a human chromosome 22-specific Fosmid library. (1995) (14)
Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with bacterial artificial chromosome clones. (1997) (14)
Genetic Analysis of Escherichia coli (2003) (13)
The basis of high resolution separation of small DNAs by asymmetric-voltage field inversion electrophoresis and its application to DNA sequencing gels. (1990) (13)
The Mechanism of Phase Variation (1980) (13)
Use of Radioactive Antibodies for Characterizing Antigens and Application to the Study of Flagella Synthesis (1968) (13)
Homology between the invertible deoxyribonucleic acid sequence that controls flagellar-phase variation in Salmonella sp. and deoxyribonucleic acid sequences in other organisms (1981) (13)
Selection of chromosome 22-specific clones from human genomic BAC library using a chromosome-specific cosmid library pool. (1994) (12)
Bax is not the heterodimerization partner necessary for sustained anti-photoreceptor-cell-death activity of Bcl-2. (2002) (12)
The effects of symmetrical recombination site hixC on Hin recombinase function. (1992) (12)
Gq Signaling Is Required for Allergen-Induced Pulmonary Eosinophilia1 (2002) (12)
Conditionally expressed Gα15 couples to endogenous receptors in GH3 cells (2001) (11)
Studies of the diphtheria toxin receptor on Chinese hamster cells. (1978) (11)
A human chromosome 22 fosmid resource: mapping and analysis of 96 clones. (1996) (10)
Methacholine-induced airway hyperresponsiveness is dependent on Galphaq signaling. (2003) (10)
Selection of a sublibrary enriched for a chromosome from total human bacterial artificial chromosome library using DNA from flow sorted chromosomes as hybridization probes. (1995) (10)
Assembly of Hybrid Flagellar Filaments (1974) (10)
Variation in the Primary Structure of Bacillus subtilis Flagellins (1971) (10)
The Specificity of Interferon Induction (1971) (10)
Intracellular Signaling and the Origins of the Sensations of Itch and Pain (2011) (10)
Purification and characterization of the wild-type and mutant carboxy-terminal domains of the Escherichia coli Tar chemoreceptor (1988) (10)
A high resolution integrated yeast artificial chromosome clone map of human chromosome 22. (1995) (10)
Chapter 1 Sensory Transduction in Bacteria (1985) (9)
Dysfunctional genomics: BACs to the rescue (1997) (9)
Distinct Forms of the ß Subunit of GTP-Binding Regulatory Proteins Identified by Molecular (9)
Synthesis of Bacterial Flagella: Chromosomal Synchrony and Flagella Synthesis (1969) (7)
Random Mutagenesis of G protein a Subunit Goa MUTATIONS ALTERING NUCLEOTIDE BINDING* (2001) (7)
Random cysteine disulfide crosslinking in the analysis of protein structure (1991) (6)
Methods in enzymology index (1995) (6)
Signal Transduction in Microorganisms (1995) (6)
Transposon Mutagenesis ofMarineVibrio spp. (1984) (6)
Mutational analysis of G protein alpha subunit G(o) alpha expressed in Escherichia coli. (1993) (6)
Transcriptional regulatory regions of testis-specific PGK 2 defined in transgenic mice ( spermatogenesis / translational regulation / luciferase ) MURRAY 0 (5)
Activation of phospholipase C 132 by the av and 13 y subunits of trimeric GTP-binding protein (2005) (5)
Alternative splicing produces transcripts encoding two forms of the a subunit of GTP-binding protein G 0 ( guanine nucleotide-binding protein / signal transduction ) (5)
fosmid-based genomic map and identification of 474 genes of the hyperthermophilic archaeon (5)
Signaling and Cross-talk by C5a and UDP in Macrophages Selectively Use PLC3 to Regulate Intracellular (2008) (5)
Identification oftheStructural GenefortheHookSubunit Protein ofEscherichia coli Flagella (1978) (5)
Functional analysis of a dominant negative mutant of G alpha i2. (1995) (4)
Genetic Analysis ofBacteriophage Mu-Induced Flagellar MutantsinEscherichia coli (1973) (4)
Bipolar Cells in the Mouse Retina The Human Blue Opsin Promoter Directs Transgene Expression in Short-Wave Cones and (2006) (4)
A FAMILY OF HOMOLOGOUS GENES ENCODING SENSORY TRANSDUCERS IN E. COLI (1983) (3)
DIPHTHERIA TOXIN INTERACTIONS WITH AN INHIBITORY ACTIVITY FROM PLASMA MEMBRANES (1981) (3)
Crystallization and preliminary X-ray analysis of the DNA binding domain of the Hin recombinase with its DNA binding site. (1993) (3)
Conditionally expressed G alpha 15 couples to endogenous receptors in GH3 cells. (2001) (2)
Transgenic Mouse Studies of Retinal Degeneration: Expression of The β-Subunit of cGMP Phosphodiesterase and Transducin α-Subunits (1993) (2)
[7] Photosensitized oxidation of purines and pyrimidines (1967) (2)
Alfred Gilman (1941–2015) (2016) (1)
Evidence for Two Pathways Leading to Light-Induced Retinal Degeneration (2002) (1)
Muscarinic M1 inhibition of calcium current, but not M-type potassium current, is reduced in G alpha q knockout mice (1998) (1)
Gal 2 and Ga 13 subunits define a fourth class of G protein a subunits ( GTP-binding protein / signal transduction (1)
Untangling Dendrites with Quantitative Models (2000) (1)
Extravasation of Leukocytes from Circulation is Controlled by Gαi2 Signaling Events in the Endothelium (2007) (1)
Light Induced Photoreceptor Apoptosis: Is Phototransduction Involved? (2002) (1)
Cellular and bioenergetic dysfunction induced by loss of the Wolfram Syndrome protein, Miner1, can be reversed by treatment with N-acetylcysteine (2013) (1)
I Metabotropic Glutamate Receptor Signaling via G q / G 11 Secures the Induction of Long-Term Potentiation in the Hippocampal Area CA 1 (2002) (1)
Expression of the Bacillus subtilis spolVB gene is under dual aF / aG control (2008) (1)
Microbial role in biodeterioration: genetic approaches (1988) (1)
Regulate TLR-Mediated Gene Expression Uncovers Feedback Mechanisms That Dual Ligand Stimulation of RAW 264 . 7 Cells (2006) (1)
Phospholipase beta-4-knockout mouse exhibits retinal phenotype (1996) (1)
Analysis of C 5 a-mediated chemotaxis by lentiviral delivery of small interfering RNA (2004) (1)
Effects of Blue- and Green Light in Arrestin / Rhodopsinkinase Double Knock Out (Arr-/- / RK -/-) Mice (2003) (1)
Synergistic Ca 2 Responses by G i - and G q -coupled G-protein-coupled Receptors Require a Single PLC Isoform (2011) (1)
Cloning and expression of the flagellar hook gene on hybird plasmids in minicells. (1977) (0)
Identification of Related mRNAs Repetitive Segmental Structure of the Transducin ß Subunit : Homology with the CDC 4 Gene and (2003) (0)
Subject Index, Vol. 72, 1996 (1996) (0)
Biopolymers: protein and nucleic acids. Annual report, 15 September 1987-14 September 1988 (1988) (0)
Biopolymers: Proteins and Nucleic Acids. (1990) (0)
PhaseVariation andtheHinProtein: InVivoActivity Measurements, Protein Overproduction, andPurification (1984) (0)
[Developing a physical map of human chromosome 22]. Progress report (1991) (0)
Assembly ofHybridFlagellar Filaments (1974) (0)
An integrated BAC/PAC molecular cytogenetic resource for human genetics: Applications to disease (1996) (0)
303 Multiple climbing fiber innervation of cerebellar purkinje cells in mutant mice lacking the α-subunit of geterotrimeric G protein Gq(Gαq) (1997) (0)
STRUCTURE OF CHEA DOMAIN P4 IN COMPLEX WITH TNP-ATP (2001) (0)
STRUCTURE OF SIGNAL TRANSDUCTION PROTEIN CHEY (1997) (0)
Immobilized Enzymes and Cells. Vol. 137, Pt. D (1988) (0)
Genome rearrangement: Proceedings of the UCLA symposium held at Steamboat Springs, Colorado, April 7-13, 1984 (1985) (0)
Retinal Degeneration in Transgenic Mouse Expressing the N-terminal Domain of RGS9 (2002) (0)
The Gar , and Garll Proteins Couple the Thyrotropin-releasing Hormone Receptor to Phospholipase C in GH 3 Rat Pituitary Cells * (2001) (0)
STRUCTURE OF CHEA DOMAIN P4 IN COMPLEX WITH ADPCP AND MANGANESE (2001) (0)
Control of Caenorhabditis Elegans Behaviour and Development by G Proteins Big and Small (2004) (0)
Toward an Integrated BAC Library Resource for Genome Sequencing and Analysis (2002) (0)
Detecting Mitochondrial Genotypes by Temperature Gradient Gel Electrophoresis and Heteroduplex Analysis (1999) (0)
Acute, pharmacologic inhibition of the mitochondrial pyruvate carrier enhances cellular glucose uptake and potentiates metabolic flexibility (2013) (0)
Bipolymers: Proteins and Nucleic Acids. (1995) (0)
Thebasis ofhighresolution separation ofsmall DNAsby asymmetric-volta ge field inversion electrophoresis andits application toDNAsequencing gels (1990) (0)
Chimeric chemosensory transducers of Escherichia coli ( chemotaxls / methyl-accepting chemotaxls proteins / gene family / gene fusion ) (0)
Accompanied by Transposition and Inversion Evolution and Organization of the Fibrinogen Locus on Chromosome 4 : Gene Duplication (0)
Biochemistry of Bacterial Flagella (1973) (0)
in Vibrio parahaemolyticus. Regulation of lateral flagella gene transcription (2013) (0)
Chemotactic Control oftheTwoFlagellar Systems of (1990) (0)
Final Report: Complete Sequencing of the 2.3Mbp Genome of the Hyperthermophilic Archaeon Pyrbaculum Aerophilum, January 1, 1998 - December 31, 1998 (1998) (0)
An Integrated BAC/PAC Resource for identifying chromosomal abnormalities in solid tumors (2000) (0)
Developing a physical map of human chromosome 22) (1991) (0)
Activation of Phosphate Group Transfer Transmembrane Signal Transduction in Bacterial Chemotaxis Involves Ligand-Dependent (2006) (0)
Purification andCharacterization oftheWild-Type andMutant Carboxy-Terminal Domains oftheEscherichia coli TarChemoreceptor (1988) (0)
Characterization ofEscherichia coli Chemotaxis Receptor Mutants withNullPhenotypes (1986) (0)
Xanthine nucleotide binding Go alpha mutant (1996) (0)
Studies of the diphtheria toxin receptor (1978) (0)
Activation and Densensitization in Bacterial Chemotaxis (1990) (0)
Synthesis ofBacterial Flagella: Chromosomal Synchrony andFlagella Synthesis (1969) (0)
[Developing a physical map of human chromosome 22 using Pace electrophoresis and large fragment cloning]. Annual report, October 1, 1989--September 30, 1990 (1990) (0)
STRUCTURE OF THE HISTIDINE KINASE CHEA ATP-BINDING DOMAIN IN COMPLEX WITH ADPNP AND MAGENSIUM (2001) (0)
CRYSTAL STRUCTURE OF CHEA-289, A SIGNAL TRANSDUCING HISTIDINE KINASE (1999) (0)
Genetic Analysis ofFlagellar Mutantsin Escherichia coli (1973) (0)
Chemotaxis in Escherichia col: Methylation of che gene pmoducts (2003) (0)
Subject Index Vol. 39, 1985 (1985) (0)
Cumulative subject index, volumes 290-319. (2000) (0)
autophosphorylation by transducer and CheW. kinase mediates regulation of The carboxy-terminal portion of the CheA (2013) (0)
A segment of the C-terminal half of the G-protein . 31 subunit specifies its interaction with the y 4 subunit ( signal transduction / phospholipase / fty dimers (0)
Mixed g-protein composition and its use (1997) (0)
ADP-Ribosylation Site for Pertussis Toxin Identification of a GTP-Binding Protein alpha Subunit that Lacks an Apparent (2006) (0)
Chemotaxis kinase CheA P2 domain in complex with response regulator CheY from the thermophile thermotoga maritima (2004) (0)
Development of BAC libraries and integrated physical mapping of human chromosome 22 using BACs. Annual report, July 1994--June 1995 (1995) (0)
Methods in enzymology on CD-ROM, CD-1 : recombinant DNA and related methodology (1995) (0)
[Melting in adsorbed films]. Progress report 1992 (1992) (0)
Diphtheria toxin inhibitory activity from rabbit liver plasma membranes (1979) (0)
Biopolymers: Protein and Nucleic Acids (1987) (0)
Instability of GGL Domain-containing RGS Proteins in Mice Lacking the Fifth Member of the G-protein Beta Subunit (2003) (0)
Erratum: (Journal of General Physiology (June 2004) 123:6 (729-741) ) (2005) (0)
Biomembranes : Vol. 156, Pt. P: ATP-Driven Pumps and Related Transport - The Na,K-Pump (1988) (0)
Platelets : Vol. 215, Pt. B: Receptors, Adhesion, Secretion (1992) (0)
Correction (2005) (0)
STRUCTURE OF THE HISTIDINE KINASE CHEA ATP-BINDING DOMAIN IN COMPLEX WITH ATP ANALOG ADPCP AND MAGNESIUM (2001) (0)
Solution structure of the chemotaxis protein CheW from the thermophilic organism Thermotoga maritima (2002) (0)
CheA phosphotransferase domain from Thermotoga maritima (2004) (0)
and purification. overproduction, activity measurements, protein Phase variation and the Hin protein: in vivo (2013) (0)
302 Multiple climbing fiber innervation of cerebellar purkinje cells in mutant mice lacking the phospholipase C-β4 (PLC β4) (1997) (0)
A Correction to the Perspective Titled: “Intracellular Signaling and the Origins of the Sensations of Itch and Pain” by S.-K. Han and M. I. Simon (2011) (0)
Melting in adsorbed films (1992) (0)
Biomembranes : Vol. 191, Pt. V: Cellular and Subcellular Transport - Epithelial Cells (1990) (0)
PNAS Paper: Rules and Standard Practice (1990) (0)

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