Mary-jane H. Gething
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Mary-jane H. Gethingmathematics Degrees
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Mathematics
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(Suggest an Edit or Addition)Mary-jane H. Gething's Published Works
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Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Protein folding in the cell (1992) (4027)
- The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins (1988) (1208)
- A transmembrane protein with a cdc2+ CDC28 -related kinase activity is required for signaling from the ER to the nucleus (1993) (812)
- Expression of wild-type and mutant forms of influenza hemagglutinin: The role of folding in intracellular transport (1986) (751)
- Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP (1993) (658)
- Role and regulation of the ER chaperone BiP. (1999) (564)
- S. cerevisiae encodes an essential protein homologous in sequence and function to mammalian BiP (1989) (407)
- A 22 bp cis‐acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins. (1992) (379)
- The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum (1993) (364)
- Antigen Presentation Pathways to Class I and Class II MHC‐Restricted T Lymphocytes (1987) (339)
- Studies on the mechanism of membrane fusion: site-specific mutagenesis of the hemagglutinin of influenza virus (1986) (314)
- Cloning and DNA sequence of double-stranded copies of haemagglutinin genes from H2 and H3 strains elucidates antigenic shift and drift in human influenza virus (1980) (287)
- Common and divergent peptide binding specificities of hsp70 molecular chaperones. (1994) (278)
- Purification of the fusion protein of Sendai virus: analysis of the NH2-terminal sequence generated during precursor activation. (1978) (257)
- Guidebook to the molecular chaperones and protein-folding catalysts (1997) (253)
- Serpin-resistant mutants of human tissue-type plasminogen activator (1989) (237)
- Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. (1992) (226)
- Haemagglutinin of influenza virus expressed from a cloned gene promotes membrane fusion (1982) (201)
- Construction of influenza haemagglutinin genes that code for intracellular and secreted forms of the protein (1982) (195)
- Cell-surface expression of influenza haemagglutinin from a cloned DNA copy of the RNA gene (1981) (194)
- Peptide-dependent stimulation of the ATPase activity of the molecular chaperone BiP is the result of conversion of oligomers to active monomers. (1993) (155)
- Amino acid residues that affect interaction of tissue-type plasminogen activator with plasminogen activator inhibitor 1. (1990) (138)
- Proline isomerases function during heat shock. (1993) (134)
- Mutations in the cytoplasmic domain of the influenza virus hemagglutinin affect different stages of intracellular transport (1985) (129)
- Influenza virus hemagglutinin expression is polarized in cells infected with recombinant SV40 viruses carrying cloned hemagglutinin DNA (1983) (124)
- BiP Binding Sequences in Antibodies (*) (1995) (120)
- Translocation in yeast and mammalian cells: not all signal sequences are functionally equivalent (1987) (103)
- T-cell cytotoxicity in the absence of viral protein synthesis in target cells (1977) (102)
- Addition of carbohydrate side chains at novel sites on influenza virus hemagglutinin can modulate the folding, transport, and activity of the molecule (1988) (98)
- Variant influenza virus hemagglutinin that induces fusion at elevated pH (1986) (97)
- Heterologous transmembrane and cytoplasmic domains direct functional chimeric influenza virus hemagglutinins into the endocytic pathway (1986) (96)
- Analysis of progressive deletions of the transmembrane and cytoplasmic domains of influenza hemagglutinin (1986) (95)
- Variants of human tissue‐type plasminogen activator that lack specific structural domains of the heavy chain. (1988) (91)
- HSP70 Binding Sites in the Tumor Suppressor Protein p53* (1997) (90)
- Glycosylation requirements for intracellular transport and function of the hemagglutinin of influenza virus (1992) (90)
- Formation of protein micelles from amphiphilic membrane proteins. (1978) (89)
- Expression of a full-length cDNA coding for human intestinal lactase-phlorizin hydrolase reveals an uncleaved, enzymatically active, and transport-competent protein. (1991) (88)
- The cellular response to unfolded proteins: intercompartmental signaling. (1994) (88)
- The expression of influenza virus hemagglutinin in the pancreatic β cells of transgenic mice results in autoimmune diabetes (1990) (86)
- On the role of the transmembrane anchor sequence of influenza hemagglutinin in target cell recognition by class I MHC-restricted, hemagglutinin-specific cytolytic T lymphocytes (1987) (85)
- Lines of BPV‐transformed murine cells that constitutively express influenza virus hemagglutinin. (1985) (83)
- Converting tissue plasminogen activator to a zymogen: a regulatory triad of Asp-His-Ser. (1993) (81)
- Disulfide bond formation during the folding of influenza virus hemagglutinin (1992) (79)
- Restoration of serine protease-inhibitor interaction by protein engineering. (1990) (79)
- Only three of the seven human chorionic gonadotropin beta subunit genes can be expressed in the placenta. (1984) (78)
- Influenza virus RNA segment 7 has the coding capacity for two polypeptides. (1980) (77)
- Cytotoxic T lymphocyte recognition of the influenza hemagglutinin gene product expressed by DNA-mediated gene transfer (1984) (77)
- The single-chain form of tissue-type plasminogen activator has catalytic activity: studies with a mutant enzyme that lacks the cleavage site. (1989) (67)
- Protein structure. Chaperones, paperones. (1989) (64)
- The Saccharomyces cerevisiae DPM1 gene encoding dolichol-phosphate-mannose synthase is able to complement a glycosylation-defective mammalian cell line (1990) (63)
- SV40 T antigen and the exocytotic pathway. (1985) (62)
- Transport and assembly processes in the endoplasmic reticulum. (1990) (61)
- Recognition of viral glycoproteins by influenza A-specific cross- reactive cytolytic T lymphocytes (1980) (61)
- The molar absorption coefficient of reduced Ellman's reagent : 3-carboxylato-4-nitro-thiophenolate (1972) (60)
- BiP-binding Sequences in HIV gp160 (1999) (58)
- Association of stress proteins with autoantigens: a possible mechanism for triggering autoimmunity? (2003) (58)
- Fusion of Sendai virus with the target cell membrane is required for T cell cytotoxicity (1978) (58)
- Protein transport and secretion (1983) (55)
- Low density lipoprotein receptor-related protein is necessary for the internalization of both tissue-type plasminogen activator-inhibitor complexes and free tissue-type plasminogen activator. (1994) (53)
- Cell-free synthesis of enzymically active tissue-type plasminogen activator. Protein folding determines the extent of N-linked glycosylation. (1992) (50)
- Chorismate mutase/prephenate dehydratase from Escherichia coli K12. 1. The effect of NaCl and its use in a new purification involving affinity chromatography on sepharosyl-phenylalanine. (1976) (50)
- Identification of immunoglobulin heavy chain binding protein as glucose-regulated protein 78 on the basis of amino acid sequence, immunological cross-reactivity, and functional activity (1989) (49)
- The functional efficiency of a mammalian signal peptide is directly related to its hydrophobicity. (1990) (47)
- Binding sites for Hsp70 molecular chaperones in natural proteins. (1995) (43)
- The Yeast Inositol Polyphosphate 5-Phosphatases Inp52p and Inp53p Translocate to Actin Patches following Hyperosmotic Stress: Mechanism for Regulating Phosphatidylinositol 4,5-Bisphosphate at Plasma Membrane Invaginations (2000) (37)
- Tissue-type plasminogen activator-induced invasion and metastasis of murine melanomas. (1995) (37)
- Characterization of intraocular tumors arising in transgenic mice. (1994) (37)
- Tyrosine 67 in the epidermal growth factor-like domain of tissue-type plasminogen activator is important for clearance by a specific hepatic receptor. (1992) (36)
- SCFCdc4-mediated degradation of the Hac1p transcription factor regulates the unfolded protein response in Saccharomyces cerevisiae. (2006) (35)
- Substrate Binding Induces Depolymerization of the C-terminal Peptide Binding Domain of Murine GRP78/BiP* (1998) (34)
- Expression of lactase-phlorizin hydrolase in sheep is regulated at the RNA level. (1994) (34)
- The pro region of human intestinal lactase-phlorizin hydrolase. (1994) (32)
- Lobe IB of the ATPase domain of Kar2p/BiP interacts with Ire1p to negatively regulate the unfolded protein response in Saccharomyces cerevisiae. (2007) (31)
- Chorismate mutase/prephenate dehydratase from Escherichia coli K12. Effects of chemical modification on the enzymic activities and allosteric inhibition. (1977) (30)
- Construction of intergeneric hybrids using bacteriophage P1CM: transfer of the Klebsiella aerogenes ribitol dehydrogenase gene to Escherichia coli (1976) (29)
- The Yeast Inositol Polyphosphate 5-Phosphatase Inp54p Localizes to the Endoplasmic Reticulum via a C-terminal Hydrophobic Anchoring Tail (2001) (28)
- Presentation of newly synthesized glycoproteins to CD4+ T lymphocytes. An analysis using influenza hemagglutinin transport mutants (1993) (26)
- Rejection of intraocular tumors from transgenic mice by tumor-infiltrating lymphocytes. (1994) (26)
- Protein folding: The difference with prokaryotes (1997) (25)
- 12 – Studies on the Mechanism of Membrane Fusion (1973) (25)
- Cloned copy of the haemagglutinin gene codes for human influenza antigenic determinants in E. coli (1981) (25)
- Influenza virus haemagglutinin signal sequence (1979) (24)
- 5 Structure, Function, and Regulation of the Endoplasmic Reticulum Chaperone, BiP (1994) (24)
- The unfolded protein response transducer Ire1p contains a nuclear localization sequence recognized by multiple beta importins. (2006) (23)
- Protein folding and intracellular transport: evaluation of conformational changes in nascent exocytotic proteins. (1989) (22)
- Posttranslational translocation of influenza virus hemagglutinin across microsomal membranes (1987) (22)
- Molecular chaperones: Clasping the prize (1996) (22)
- Normal protein folding machinery. (1996) (21)
- Relationship between the messenger RNAs transcribed from two overlapping genes of influenza virus. (1980) (21)
- Chorismate mutase/prephenate dehydratase from Escherichia coli K12. Modification with 5,5'-dithio-bis(2-nitrobenzoic acid). (1977) (20)
- Expression of human tissue-type plasminogen activator from lytic viral vectors and in established cell lines. (1986) (19)
- ChorismateMutase/Prephenate Dehydratase from Escherichia coli K12 (1976) (19)
- Isolation of Chinese hamster ovary cell lines temperature conditional for the cell-surface expression of integral membrane glycoproteins (1989) (18)
- Addition of truncated oligosaccharides to influenza virus hemagglutinin results in its temperature-conditional cell-surface expression (1989) (18)
- Chapter 11 Fusion Activity of the Hemagglutinin of Influenza Virus (1988) (17)
- Chorismate mutase/prephenate dehydratase from Escherichia coli K12. Binding studies with the allosteric effector phenylalanine. (1978) (15)
- Inhibitor-Resistant Tissue-Type Plasminogen Activator: An Improved Thrombolytic Agent In Vitro (1994) (15)
- Capacity of simian virus 40 T antigen to induce self-tolerance but not immunological privilege in the anterior chamber of the eye. (1994) (15)
- Generation of virus‐specific cytotoxic T cells in vitro II. Induction requirements with functionally inactivated virus preparations (1980) (14)
- Complementing mutant alleles define three loci involved in mannosylation of Man5-GlcNAc2-P-P-dolichol in Chinese hamster ovary cells (1990) (14)
- Presenilin mutants subvert chaperone function (2000) (12)
- Protein folding and intracellular transport: studies on influenza virus haemagglutinin. (1989) (12)
- Molecular chaperones: individualists or groupies? (1991) (12)
- Membrane Insertion and Intracellular Transport of Influenza Virus Glycoproteins (1989) (12)
- Chorismate mutase/prephenate dehydratase from Escherichia coli K12. Effect of phenylalanine, NaCl and pH on the protein conformation. (1978) (11)
- Processing of normal lysosomal and mutant N-acetylgalactosamine 4-sulphatase: BiP (immunoglobulin heavy-chain binding protein) may interact with critical protein contact sites. (1999) (10)
- Interleukin-1 promotes hyperglycemia and insulitis in mice normally resistant to streptozotocin-induced diabetes. (1994) (8)
- Addition of an oligosaccharide side-chain at an ectopic site on the egf-like domain of t-PA prevents binding to specific receptors on hepatic cells (1989) (7)
- Expression of Cloned Influenza Virus Genes (1983) (7)
- Purification of the fusion protein of Sendai virus : Analysis of the NH 2-terminal sequence generated during precursor activation ( activation of infectivity / influenza hemagglutinin / hydrophobic amino terminus ) (4)
- Chorismate mutase/prephenate dehydratase from Escherichia coli K12. 2. Evidence for identical subunits catalysing the two activities. (1976) (4)
- Chapter 2 Mutational Analysis of the Structure and Function of the Influenza Virus Hemagglutinin (1985) (4)
- Inactivation of PRIM 1 Function Sensitizes Cancer Cells to ATR and CHK 1 Inhibitors 1 (2003) (3)
- The Saccharomyces cerevisiae DPM 1 Gene Encoding Dolichol-Phosphate-Mannose Synthase Is Able To Complement a Glycosylation-Defective Mammalian Cell Line (3)
- The Purification and Structural Characterization of the Fusion Factor of Sendai Virus (1978) (3)
- The Unfolded Protein Response Transducer Ire1p Contains a Nuclear Localization Sequence Recognized by Multiple Importins (2006) (3)
- Mutants of human time-type plasminogen activator that are resistant to inhibition by the serpin PAI-1 (1989) (2)
- SECONDARY SENDAI-SPECIFIC T-EFFECTOR CELLS: REQUIREMENTS FOR RESTIMULATION, TARGET CELLS RECOGNITION, AND LYSIS (1979) (1)
- Expression of Proteins on the Cell Surface Using Mammalian Vectors (1983) (1)
- Complexes oftissue-type plasminogen activator anditsserpin inhibitor plasminogen-activator inhibitor type1areinternalized bymeansofthelowdensity lipoprotein receptor-related (1992) (1)
- Generation and characterization of cleavage-minus mutants of human tissue-plasminogen activator (1987) (1)
- Nonlethal sec71-1 andsec72-1 Mutations Eliminate Proteins Associated withtheSec63p-BiP Complex (1994) (0)
- Abstract 1971: Analysis and manipulation of fluorescent proteins as a guided-inquiry classroom laboratory project (2023) (0)
- Immunolocalization of the intracellular sites of accumulation of mutant influenza hemagglutinins by Electron Microscopy (1989) (0)
- Host antigens associated with haemagglutinin. (1985) (0)
- Exon-shuffling and deletion mutants of human tissue plasminogen activator (1987) (0)
- The use of “loop-switch” mutations to probe fine structure(function relationships in the kringle II domain of t-PA (1989) (0)
- ANALYSIS OF REQUIREMENTS FOR CELL MEDIATED LYSIS INTERACTION BETWEEN VIRAL GLYCOPROTEINS AND CELL PLASMA MEMBRANES (1979) (0)
- Variants ofhumantissue-type plasminogen activator thatlackspecific structural domainsoftheheavychain (1988) (0)
- TPA mutants resistant to inhibition by their similar inhibitors. (1990) (0)
- Construction ofIntergeneric Hybrids UsingBacteriophage P1CM:Transfer oftheKlebsiella aerogenesRibitol Dehydrogenase GenetoEscherichia coli (1976) (0)
- Experimental Medicine Edited by R Recognition of Viral Glycoproteins by Influenza Α-specific Cross-reactive Cytolytic Τ Lymphocytes* Materials and Methods (0)
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