Marcel Kool
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Computer Science
Marcel Kool's Degrees
- PhD Computer Science University of Amsterdam
- Masters Artificial Intelligence University of Amsterdam
- Bachelors Computer Science University of Amsterdam
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(Suggest an Edit or Addition)Marcel Kool's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- Signatures of mutational processes in human cancer (2013) (7589)
- Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma (2012) (2074)
- A family of drug transporters: the multidrug resistance-associated proteins. (2000) (1715)
- Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. (2012) (1532)
- Molecular subgroups of medulloblastoma: the current consensus (2011) (1507)
- DNA methylation-based classification of central nervous system tumours (2018) (1461)
- Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. (1997) (935)
- The landscape of genomic alterations across childhood cancers (2018) (880)
- Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas (2012) (855)
- Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups. (2015) (782)
- Dissecting the genomic complexity underlying medulloblastoma (2012) (777)
- K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas (2012) (766)
- Subgroup-specific structural variation across 1,000 medulloblastoma genomes (2012) (760)
- Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations (2012) (755)
- Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features (2008) (682)
- The multidrug resistance protein family. (1999) (664)
- The whole-genome landscape of medulloblastoma subtypes (2017) (658)
- Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome. (2011) (643)
- Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA. (1998) (639)
- Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma (2013) (637)
- MRP3, an organic anion transporter able to transport anti-cancer drugs. (1999) (636)
- New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs (2016) (608)
- Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. (2014) (601)
- Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. (2013) (575)
- Medulloblastomics: the end of the beginning (2012) (559)
- A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin‐Johnson syndrome (1997) (529)
- Mutations in ABCC6 cause pseudoxanthoma elasticum (2000) (528)
- Epigenomic alterations define lethal CIMP-positive ependymomas of infancy (2014) (507)
- Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma (2014) (496)
- Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2. (1999) (461)
- Risk stratification of childhood medulloblastoma in the molecular era: the current consensus (2016) (406)
- Patterns of somatic structural variation in human cancer genomes (2020) (377)
- Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes. (2016) (374)
- Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations (2012) (366)
- Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma. (2013) (362)
- Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing (2014) (362)
- The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation (2013) (338)
- Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells. (1999) (321)
- Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples (2011) (318)
- Identification of genes involved in DNA replication of the Autographa californica baculovirus. (1994) (306)
- Active medulloblastoma enhancers reveal subgroup-specific cellular origins (2016) (296)
- Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis. (2013) (295)
- Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers (2015) (269)
- Divergent clonal selection dominates medulloblastoma at recurrence (2016) (266)
- Tissue Distribution and Induction of Human Multidrug Resistant Protein 3 (2002) (261)
- Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system (2013) (254)
- Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas (2013) (250)
- Cytogenetic prognostication within medulloblastoma subgroups. (2014) (242)
- Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. (2014) (235)
- Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies. (2000) (233)
- Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays (2013) (230)
- Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors. (2015) (226)
- The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants (2016) (220)
- Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-, MRP1- and MRP2-mediated transport (2000) (216)
- Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort (2018) (212)
- Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study. (2013) (205)
- Comprehensive molecular characterization of mitochondrial genomes in human cancers (2017) (197)
- Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations (2013) (194)
- Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets (2016) (188)
- HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma. (2016) (187)
- mSWI/SNF (BAF) Complexes Facilitate Decatentation of DNA by Topoisomerase IIα (2013) (184)
- Histone deacetylase 10 promotes autophagy-mediated cell survival (2013) (169)
- Detection and analysis of Autographa californica nuclear polyhedrosis virus mutants with defective interfering properties. (1991) (167)
- Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity (2013) (165)
- Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance (2015) (165)
- Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma (2013) (164)
- Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas (2018) (162)
- Recurrent MET fusion genes represent a drug target in pediatric glioblastoma (2016) (160)
- Therapeutic Targeting of Ependymoma as Informed by Oncogenic Enhancer Profiling (2017) (157)
- Prognostic Value of Medulloblastoma Extent of Resection After Accounting for Molecular Subgroup: An Integrated Clinical and Molecular Analysis (2016) (156)
- FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma. (2011) (152)
- Sarcoma classification by DNA methylation profiling (2021) (147)
- An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity (2020) (147)
- TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma (2013) (146)
- Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome (2017) (145)
- Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity (2015) (145)
- Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes (2019) (139)
- Replication of baculovirus DNA. (1995) (131)
- Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles (2016) (129)
- Drug resistance-associated markers P-glycoprotein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, and lung resistance protein as prognostic factors in ovarian carcinoma. (1999) (128)
- Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis. (2016) (127)
- Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors (2020) (126)
- Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial. (2018) (120)
- Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort (2014) (120)
- Poorly differentiated chordoma with SMARCB1/INI1 loss: a distinct molecular entity with dismal prognosis (2016) (114)
- Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups. (2018) (113)
- Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group (2013) (109)
- Genomic imbalances in rhabdomyosarcoma cell lines affect expression of genes frequently altered in primary tumors: An approach to identify candidate genes involved in tumor development (2009) (108)
- The G-protein Alpha Subunit Gsα Is A Tumor Suppressor In Sonic Hedgehog-driven Medulloblastoma (2014) (106)
- LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR) (2012) (103)
- Treatment of Children and Adolescents With Metastatic Medulloblastoma and Prognostic Relevance of Clinical and Biologic Parameters. (2016) (102)
- Spatial heterogeneity in medulloblastoma (2017) (101)
- HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment (2012) (101)
- A biobank of patient-derived pediatric brain tumor models (2018) (99)
- Do cMOAT (MRP2), other MRP homologues, and LRP play a role in MDR? (1997) (95)
- Identification of seven putative origins of Autographa californica multiple nucleocapsid nuclear polyhedrosis virus DNA replication. (1993) (94)
- EZHIP / CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma. (2019) (92)
- A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes. (2015) (90)
- Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme (2017) (90)
- Gain of 1q As a Prognostic Biomarker in Wilms Tumors (WTs) Treated With Preoperative Chemotherapy in the International Society of Paediatric Oncology (SIOP) WT 2001 Trial: A SIOP Renal Tumours Biology Consortium Study (2016) (89)
- Epithelioid glioblastomas stratify into established diagnostic subsets upon integrated molecular analysis (2018) (87)
- Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling. (2018) (87)
- Molecular diagnostics of CNS embryonal tumors (2010) (87)
- OTX2 directly activates cell cycle genes and inhibits differentiation in medulloblastoma cells (2012) (86)
- Multiple mechanisms of MYCN dysregulation in Wilms tumour (2015) (86)
- Molecular subgrouping of atypical teratoid/rhabdoid tumors—a reinvestigation and current consensus (2019) (84)
- Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours (2019) (84)
- Coverage Bias and Sensitivity of Variant Calling for Four Whole-genome Sequencing Technologies (2013) (84)
- Location of two putative origins of DNA replication of Autographa californica nuclear polyhedrosis virus. (1993) (83)
- PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation (2011) (83)
- Differential expression and methylation of brain developmental genes define location-specific subsets of pilocytic astrocytoma (2013) (82)
- OTX1 and OTX2 Expression Correlates With the Clinicopathologic Classification of Medulloblastomas (2006) (82)
- Expression of Human MRP 6 , a Homologue of the Multidrug Resistance Protein Gene MRP 1 , in Tissues and Cancer Cells 1 (1998) (81)
- Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem (2012) (81)
- PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models. (2017) (79)
- Peptide transport by the multidrug resistance protein MRP1. (2001) (76)
- Predicting relapse in patients with medulloblastoma by integrating evidence from clinical and genomic features. (2011) (74)
- MYCN amplification drives an aggressive form of spinal ependymoma (2019) (70)
- Biological and clinical heterogeneity of MYCN-amplified medulloblastoma (2012) (70)
- The Molecular Landscape of ETMR at Diagnosis and Relapse (2019) (70)
- Germline Elongator mutations in Sonic Hedgehog medulloblastoma (2020) (69)
- Heterogeneity within the PF-EPN-B ependymoma subgroup (2018) (69)
- EZH2-Regulated DAB2IP Is a Medulloblastoma Tumor Suppressor and a Positive Marker for Survival (2012) (68)
- Evaluation of the similarity of gene expression data estimated with SAGE and Affymetrix GeneChips (2005) (68)
- Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information (2018) (68)
- Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma (2020) (68)
- Full transcriptome analysis of rhabdomyosarcoma, normal and fetal skeletal muscle: statistical comparison of multiple SAGE libraries (2005) (67)
- Silencing of SPRY1 triggers complete regression of rhabdomyosarcoma tumors carrying a mutated RAS gene. (2010) (66)
- Genomic and transcriptomic analyses match medulloblastoma mouse models to their human counterparts (2014) (65)
- Hypermutation of the Inactive X Chromosome Is a Frequent Event in Cancer (2013) (64)
- Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma (2015) (64)
- MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma (2012) (61)
- Molecular Risk Stratification of Medulloblastoma Patients Based on Immunohistochemical Analysis of MYC, LDHB, and CCNB1 Expression (2008) (61)
- Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors (2018) (58)
- Prognostic relevance of tumor-infiltrating lymphocytes and immune checkpoints in pediatric medulloblastoma (2017) (58)
- Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress (2016) (56)
- Integrated molecular characterization of IDH‐mutant glioblastomas (2018) (55)
- YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis (2019) (54)
- Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration (2019) (53)
- Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation. (2019) (53)
- FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma (2016) (52)
- Subgroup-specific localization of human medulloblastoma based on pre-operative MRI (2014) (51)
- Age and DNA-methylation subgroup as potential independent risk factors for treatment stratification in children with Atypical Teratoid/Rhabdoid Tumors (ATRT). (2019) (50)
- Functional mapping of regions of the Autographa californica nuclear polyhedrosis viral genome required for DNA replication. (1994) (50)
- Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma. (2014) (49)
- A putative non-hr origin of DNA replication in the HindIII-K fragment of Autographa californica multiple nucleocapsid nuclear polyhedrosis virus. (1994) (49)
- MRP 3 , an organic anion transporter able to transport anti-cancer drugs ( multidrug resistance y methotrexate y etoposide ) (1999) (49)
- Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1 (2014) (47)
- Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis (2019) (46)
- The WIP1 Oncogene Promotes Progression and Invasion of Aggressive Medulloblastoma Variants (2014) (45)
- Cribriform neuroepithelial tumor: molecular characterization of a SMARCB1‐deficient non‐rhabdoid tumor with favorable long‐term outcome (2017) (45)
- Extensive Molecular and Clinical Heterogeneity in Patients With Histologically Diagnosed CNS-PNET Treated as a Single Entity: A Report From the Children's Oncology Group Randomized ACNS0332 Trial. (2018) (45)
- Nestin Expression Identifies Ependymoma Patients with Poor Outcome (2012) (45)
- Bioreactor Development for Production of Viral Pesticides or Heterologous Proteins in Insect Cell Cultures a (1990) (45)
- Molecular analyses reveal close similarities between small cell carcinoma of the ovary, hypercalcemic type and atypical teratoid/rhabdoid tumor (2015) (45)
- Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis (2018) (45)
- Regulation of Cell Cycle Genes and Induction of Senescence by Overexpression of OTX2 in Medulloblastoma Cell Lines (2010) (45)
- The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells (2013) (44)
- The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors. (2014) (44)
- OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels (2012) (44)
- Diagnostics of pediatric supratentorial RELA ependymomas: integration of information from histopathology, genetics, DNA methylation and imaging (2018) (43)
- WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma (2014) (42)
- Transitioning from genotypes to epigenotypes: Why the time has come for medulloblastoma epigenomics (2014) (42)
- DNA methylation-based classification of ependymomas in adulthood: implications for diagnosis and treatment (2018) (42)
- Nonmetastatic Medulloblastoma of Early Childhood: Results From the Prospective Clinical Trial HIT-2000 and An Extended Validation Cohort. (2020) (41)
- Sex differences in oncogenic mutational processes (2019) (41)
- High levels of PROM1 (CD133) transcript are a potential predictor of poor prognosis in medulloblastoma. (2011) (40)
- Telomere dysfunction and chromothripsis (2016) (39)
- The Role of Chromatin Remodeling in Medulloblastoma (2013) (39)
- Arhgap36-dependent activation of Gli transcription factors (2014) (38)
- HGNET-BCOR Tumors of the Cerebellum: Clinicopathologic and Molecular Characterization of 3 Cases (2017) (38)
- ETMR-like infantile cerebellar embryonal tumors in the extended morphologic spectrum of DICER1-related tumors (2018) (37)
- Sellar Region Atypical Teratoid/Rhabdoid Tumors (ATRT) in Adults Display DNA Methylation Profiles of the ATRT-MYC Subgroup (2018) (35)
- Subgroup-specific prognostic signaling and metabolic pathways in pediatric medulloblastoma (2019) (35)
- Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumor suppressor (2017) (35)
- Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells (2017) (35)
- Evaluation of age-dependent treatment strategies for children and young adults with pineoblastoma: analysis of pooled European Society for Paediatric Oncology (SIOP-E) and US Head Start data (2016) (35)
- Magnetic resonance imaging surrogates of molecular subgroups in atypical teratoid/rhabdoid tumor (2018) (34)
- Loss of Smarc Proteins Impairs Cerebellar Development (2014) (34)
- Mismatch repair deficiency: a temozolomide resistance factor in medulloblastoma cell lines that is uncommon in primary medulloblastoma tumours (2012) (33)
- Diffuse glioneuronal tumour with oligodendroglioma‐like features and nuclear clusters (DGONC) – a molecularly defined glioneuronal CNS tumour class displaying recurrent monosomy 14 (2019) (33)
- Preclinical drug screen reveals topotecan, actinomycin D, and volasertib as potential new therapeutic candidates for ETMR brain tumor patients (2017) (33)
- Joint Binding of OTX2 and MYC in Promotor Regions Is Associated with High Gene Expression in Medulloblastoma (2011) (32)
- Assignment of the canalicular multispecific organic anion transporter gene (CMOAT) to human chromosome 10q24 and mouse chromosome 19D2 by fluorescent in situ hybridization. (1997) (32)
- The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma (2018) (32)
- A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors (2017) (32)
- Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma. (2018) (32)
- Low-dose Actinomycin-D treatment re-establishes the tumoursuppressive function of P53 in RELA-positive ependymoma (2016) (31)
- Papillary Tumor of the Pineal Region: A Distinct Molecular Entity (2016) (31)
- Overexpression through amplification of genes in chromosome region 17p11.2∼p12 in high-grade osteosarcoma (2004) (31)
- Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas (2016) (31)
- Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis (2020) (30)
- Identification of genes involved in the biology of atypical teratoid/rhabdoid tumours using Drosophila melanogaster (2014) (30)
- Atypical teratoid/rhabdoid tumors (ATRTs) with SMARCA4 mutation are molecularly distinct from SMARCB1-deficient cases (2020) (30)
- Comparative integrated molecular analysis of intraocular medulloepitheliomas and central nervous system embryonal tumors with multilayered rosettes confirms that they are distinct nosologic entities (2015) (30)
- The structural and functional organization of the autographa californica nuclear polyhedrosis virus genome (2005) (30)
- Telomerase activation in posterior fossa group A ependymomas is associated with dismal prognosis and chromosome 1q gain (2017) (30)
- Neogenin1 is a sonic hedgehog target in medulloblastoma and is necessary for cell cycle progression (2014) (30)
- Molecular characterization of histopathological ependymoma variants (2020) (29)
- Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells (2013) (29)
- Epidemiology, molecular classification and WHO grading of ependymoma. (2018) (29)
- Tissue Factor Regulation by miR-520g in Primitive Neuronal Brain Tumor Cells: A Possible Link between Oncomirs and the Vascular Tumor Microenvironment. (2016) (29)
- Update on molecular and genetic alterations in adult medulloblastoma (2012) (29)
- Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations (2019) (29)
- Coagulation and angiogenic gene expression profiles are defined by molecular subgroups of medulloblastoma: evidence for growth factor‐thrombin cross‐talk (2014) (28)
- ETMR: a tumor entity in its infancy (2020) (28)
- Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile (2018) (27)
- Knockdown of EphB1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization (2015) (27)
- Intraocular Medulloepitheliomas and Embryonal Tumors With Multilayered Rosettes of the Brain: Comparative Roles of LIN28A and C19MC. (2015) (26)
- High impact of miRNA-4521 on FOXM1 expression in medulloblastoma (2019) (26)
- MYC Drives Group 3 Medulloblastoma through Transformation of Sox2+ Astrocyte Progenitor Cells. (2019) (25)
- DNA-methylation profiling discloses significant advantages over NanoString method for molecular classification of medulloblastoma (2017) (25)
- Desmoplastic myxoid tumor, SMARCB1-mutant: clinical, histopathological and molecular characterization of a pineal region tumor encountered in adolescents and adults (2019) (25)
- Single cell derived mRNA signals across human kidney tumors (2020) (24)
- PID1 (NYGGF4), a New Growth-Inhibitory Gene in Embryonal Brain Tumors and Gliomas (2013) (24)
- Signatures of mutational processes in human cancer this access benefits you. Your matters (2013) (23)
- Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours (2021) (23)
- Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples (2020) (22)
- Expression of BARHL1 in medulloblastoma is associated with prolonged survival in mice and humans (2011) (22)
- Ultra high-risk PFA ependymoma is characterized by loss of chromosome 6q. (2021) (22)
- Clinical Outcomes and Patient-Matched Molecular Composition of Relapsed Medulloblastoma (2021) (22)
- Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors (2021) (22)
- Cross-species genomics reveals oncogenic dependencies in ZFTA/C11orf95 fusion-positive supratentorial ependymomas. (2021) (22)
- Author Correction: The landscape of genomic alterations across childhood cancers (2018) (21)
- Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma (2015) (21)
- Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma (2020) (21)
- Overexpression through amplification of genes in chromosome region 17p11.2 approximately p12 in high-grade osteosarcoma. (2004) (20)
- DNA methylation profiling is a method of choice for molecular verification of pediatric WNT-activated medulloblastomas (2018) (19)
- Analysis of the antiproliferative effects of 3-deazaneoplanocin A in combination with standard anticancer agents in rhabdoid tumor cell lines. (2015) (19)
- PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum (2021) (19)
- Opposing Tumor-Promoting and -Suppressive Functions of Rictor/mTORC2 Signaling in Adult Glioma and Pediatric SHH Medulloblastoma (2018) (19)
- Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma (2021) (18)
- Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma. (2020) (17)
- Epigenetic Silencing of DKK3 in Medulloblastoma (2013) (17)
- Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation (2018) (17)
- Newly Diagnosed Metastatic Intracranial Ependymoma in Children: Frequency, Molecular Characteristics, Treatment, and Outcome in the Prospective HIT Series. (2019) (16)
- TCF4 (E2-2) harbors tumor suppressive functions in SHH medulloblastoma (2019) (16)
- Relevance of Molecular Groups in Children with Newly Diagnosed Atypical Teratoid Rhabdoid Tumor: Results from Prospective St. Jude Multi-institutional Trials (2021) (16)
- Subgroup and subtype-specific outcomes in adult medulloblastoma (2021) (15)
- Molecular dissection of ependymomas (2015) (15)
- Combined BRD4 and CDK9 inhibition as a new therapeutic approach in malignant rhabdoid tumors (2017) (15)
- Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation (2017) (15)
- SMARCB1 loss interacts with neuronal differentiation state to block maturation and impact cell stability (2020) (15)
- Corrigendum: Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma (2012) (15)
- Molecular characterization of medulloblastomas with extensive nodularity (MBEN) (2018) (15)
- Long-term survival in a case of ETANTR with histological features of neuronal maturation after therapy (2015) (14)
- Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation (2021) (14)
- Modeling SHH-driven medulloblastoma with patient iPS cell-derived neural stem cells (2020) (14)
- Preoperative systemic levels of VEGFA, IL‐7, IL‐17A, and TNF‐β delineate two distinct groups of children with brain tumors (2016) (14)
- Functional loss of a noncanonical BCOR–PRC1.1 complex accelerates SHH-driven medulloblastoma formation (2020) (14)
- The AHR pathway represses TGFβ-SMAD3 signalling and has a potent tumour suppressive role in SHH medulloblastoma (2020) (13)
- Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas (2021) (13)
- Corrigendum: Signatures of mutational processes in human cancer (2013) (13)
- Targeting Polo-like kinase 1 in SMARCB1 deleted atypical teratoid rhabdoid tumor (2017) (13)
- Combined BRD4 and CDK9 inhibition as a new therapeutic approach in malignant rhabdoid tumors. (2017) (12)
- Somatostatin receptor subtype 2 (sst2) is a potential prognostic marker and a therapeutic target in medulloblastoma (2013) (11)
- Expression of HumanMRP6, a Homologue of the Multidrug Resistance Protein GeneMRP1, in Tissues and Cancer Cells (1998) (11)
- MRI Features of Histologically Diagnosed Supratentorial Primitive Neuroectodermal Tumors and Pineoblastomas in Correlation with Molecular Diagnoses and Outcomes: A Report from the Children's Oncology Group ACNS0332 Trial (2019) (11)
- FOXR2 Stabilizes MYCN Protein and Identifies Non–MYCN-Amplified Neuroblastoma Patients With Unfavorable Outcome (2021) (11)
- Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age (2015) (11)
- Advances in Brief Antifolate Resistance Mediated by the Multidrug Resistance Proteins MRP 1 and MRP 21 (2000) (10)
- Aberrant immunostaining pattern of the CD24 glycoprotein in clinical samples and experimental models of pediatric medulloblastomas (2015) (10)
- Clinical response to nivolumab in an INI1-deficient pediatric chordoma correlates with immunogenic recognition of brachyury (2021) (10)
- Overexpression of minichromosome maintenance protein 10 in medulloblastoma and its clinical implications (2017) (10)
- Transcriptional profiling of medulloblastoma with extensive nodularity (MBEN) reveals two clinically relevant tumor subsets with VSNL1 as potent prognostic marker (2019) (10)
- Therapeutic implications of improved molecular diagnostics for rare CNS-embryonal tumor entities: results of an international, retrospective study. (2021) (10)
- Potential Importance of Early Focal Radiotherapy Following Gross Total Resection for Long-Term Survival in Children With Embryonal Tumors With Multilayered Rosettes (2020) (9)
- Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors. (2021) (9)
- A single supratentorial high‐grade neuroepithelial tumor with two distinct BCOR mutations, exceptionally long complete remission and survival (2020) (9)
- Statistical comparison of two or more SAGE libraries: one tag at a time. (2008) (9)
- Nucleotide sequence and genetic organization of a 7.3 kb region (map unit 47 to 52.5) of Autographa californica nuclear polyhedrosis virus fragment EcoRI-C. (1994) (9)
- The oncogenic fusion landscape in pediatric CNS neoplasms (2022) (9)
- Targeting fibroblast growth factor receptors to combat aggressive ependymoma (2021) (9)
- A new monoclonal antibody, P2A8(6), that specifically recognizes a novel epitope on the multidrug resistance-associated protein 1 (MRP1), but not on MRP2 nor MRP3. (2001) (9)
- Abstract B73: Second-generation molecular subgrouping of medulloblastoma: An international meta-analysis of Group 3 and Group 4 subtypes (2020) (9)
- Production of (recombinant) baculoviruses in a two stage bioreactor system using insect-cell cultures. (1990) (8)
- Atypical teratoid/rhabdoid tumor arising in a malignant glioma (2017) (8)
- The genetic landscape of choroid plexus tumors in children and adults. (2020) (8)
- SMAD dependent signaling plays a detrimental role in a fly model of SMARCB1-deficiency and the biology of atypical teratoid/rhabdoid tumors (2017) (8)
- HIGH GRADE GLIOMAS (2012) (8)
- ICGC PedBrain - dissecting the genomic complexity underlying medulloblastoma using whole-genome sequencing (2012) (8)
- Spinal cord atypical teratoid/rhabdoid tumors in children: Clinical, genetic, and outcome characteristics in a representative European cohort (2020) (7)
- Identification of genes involved in AcMNPV DNA replication. (1994) (7)
- Production of Baculovirus or Recombinant Derivatives in Continuous Insect‐Cell Bioreactors (1990) (7)
- Pilocytic Astrocytoma demethylation and transcriptional landscapes link bZIP transcription factors to immune response. (2020) (7)
- Production of (Recombinant) Baculoviruses in Insect-Cell Bioreactors (1992) (7)
- Histopathological patterns in atypical teratoid/rhabdoid tumors are related to molecular subgroup (2021) (7)
- Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors (2018) (7)
- Defining the molecular features of radiation-induced glioma: A systematic review and meta-analysis (2021) (7)
- Delta-24-RGD, an Oncolytic Adenovirus, Increases Survival and Promotes Proinflammatory Immune Landscape Remodeling in Models of AT/RT and CNS-PNET (2020) (7)
- Downregulation of miR‐326 and its host gene β‐arrestin1 induces pro‐survival activity of E2F1 and promotes medulloblastoma growth (2020) (7)
- Desmoplastic/nodular medulloblastomas (DNMB) and medulloblastomas with extensive nodularity (MBEN) disclose similar epigenetic signatures but different transcriptional profiles (2019) (6)
- Tyrosinase immunohistochemistry can be employed for the diagnosis of atypical teratoid/rhabdoid tumours of the tyrosinase subgroup (ATRT‐TYR) (2020) (6)
- Sox2+ cells in Sonic Hedgehog-subtype medulloblastoma resist p53-mediated cell-cycle arrest response and drive therapy-induced recurrence (2019) (6)
- EZHIP: a new piece of the puzzle towards understanding pediatric posterior fossa ependymoma (2021) (6)
- UvA-DARE ( Digital Academic Repository ) Evaluation of the similarity of gene expression data estimated with SAGE and Affymetrix (2005) (6)
- The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors (2022) (6)
- Two molecularly distinct atypical teratoid/rhabdoid tumors (or tumor components) occurring in an infant with rhabdoid tumor predisposition syndrome 1 (2019) (5)
- GAIN OF 1Q AS A BIOMARKER IN PRE-TREATED WILMS TUMOUR IN THE SIOP WT 2001 TRIAL: A SIOP RENAL TUMOURS BIOLOGY CONSORTIUM STUDY (2014) (5)
- Rhabdoid Tumor Predisposition Syndrome (2020) (5)
- Inhibition of Rho-Associated Kinase Suppresses Medulloblastoma Growth (2019) (5)
- Integrated molecular analysis of adult Sonic Hedgehog (SHH)-activated medulloblastomas reveals two clinically relevant tumor subsets with VEGFA as potent prognostic indicator. (2021) (5)
- Clinically Tractable Outcome Prediction of Non-WNT/Non-SHH Medulloblastoma Based on TPD52 IHC in a Multicohort Study (2021) (5)
- Inhibition of nuclear export restores nuclear localization and residual tumor suppressor function of truncated SMARCB1/INI1 protein in a molecular subset of atypical teratoid/rhabdoid tumors (2021) (4)
- Scaling of gene expression data allowing the comparison of different gene expression platforms. (2008) (4)
- NEURO/MEDICAL ONCOLOGY (2013) (4)
- Transposable element insertion as a mechanism of SMARCB1 inactivation in atypical teratoid/rhabdoid tumor (2021) (4)
- Carbon ion radiotherapy eradicates medulloblastomas with chromothripsis in an orthotopic Li-Fraumeni patient-derived mouse model (2021) (4)
- Target Actionability Review: a systematic evaluation of replication stress as a therapeutic target for paediatric solid malignancies. (2021) (4)
- Rare embryonal and sarcomatous central nervous system tumours: State-of-the art and future directions. (2022) (4)
- MBCL-07. NON-METASTATIC MEDULLOBLASTOMA OF EARLY CHILDHOOD: RESULTS FROM THE PROSPECTIVE CLINICAL TRIAL HIT-2000 AND AN EXTENDED VALIDATION COHORT (2020) (4)
- Atypical Teratoid/Rhabdoid Tumor (AT/RT) With Molecular Features of Pleomorphic Xanthoastrocytoma (2021) (4)
- Reduced histone H3 K27 trimethylation is encountered in about 50% of atypical teratoid/rhabdoid tumors (AT/RT) but is not associated with molecular subgroup status and outcome (2017) (4)
- Treatment of Embryonal Tumours with Multilayered Rosettes with Carboplatin/Etoposide Induction and High-dose Chemotherapy within the Prospective P-HIT Trial. (2021) (4)
- Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts (2022) (4)
- Brain Tumor Epidemiology – A Hub within Multidisciplinary Neuro-oncology. Report on the 15th Brain Tumor Epidemiology Consortium (BTEC) Annual Meeting, Vienna, 2014 (2014) (4)
- Notch Signaling between Cerebellar Granule Cell Progenitors (2021) (4)
- Mapping pediatric brain tumors to their origins in the developing cerebellum (2021) (4)
- Abstract 3447: FSTL5 improves prognostic subclassification of medulloblastoma (2011) (3)
- The landscape of genomic alterations across childhood cancers (2018) (3)
- ATRT–SHH comprises three molecular subgroups with characteristic clinical and histopathological features and prognostic significance (2022) (3)
- Differential response of SHH-expressing adult medulloblastomas to the sonic hedgehog inhibitor vismodegib: whole-genome analysis (2019) (3)
- Identification of CD24 as a marker of Patched1 deleted medulloblastoma-initiating neural progenitor cells (2019) (3)
- Role of Multidrug Resistance Proteins (MRP) in Resistance to Antifolates and Folate Homeostasis (2002) (3)
- Baculovirus DNA replication (1994) (3)
- SIRPα is transcriptionally downregulated by epigenetic silencing in medulloblastoma (2018) (3)
- Fanconi anemia gene mutations are not involved in sporadic Wilms tumor (2010) (3)
- PPM1D is a neuroblastoma oncogene and therapeutic target in childhood neural tumors (2020) (3)
- Imaging Characteristics of CNS Neuroblastoma-FOXR2: A Retrospective and Multi-Institutional Description of 25 Cases (2022) (3)
- RhoA regulates translation of the Nogo-A decoy SPARC in white matter-invading glioblastomas (2019) (3)
- Supplemental Information New Brain Tumor Entities Emerge from Molecular Classi fi cation of CNS-PNETs (2016) (3)
- EMBR-15. DIAGNOSTIC RE-EVALUATION AND POOLED CLINICAL DATA ANALYSIS OF PATIENTS WITH PREVIOUS DIAGNOSIS OF CNS-PNET (2018) (3)
- Glial papillary tumour of the spinal cord with SMARCB1/INI1‐loss and favourable long‐term outcome (2018) (3)
- Rbbp4 loss disrupts neural progenitor cell cycle regulation independent of Rb and leads to Tp53 acetylation and apoptosis (2022) (3)
- Medulloepithelioma with peculiar clinical presentation, stem cell phenotype and aberrant DNA-methylation profile. (2015) (3)
- Improved Long-Term Survival of Patients with Recurrent Medulloblastoma Treated with a “MEMMAT-like” Metronomic Antiangiogenic Approach (2022) (3)
- Low‐grade diffusely infiltrative tumour (LGDIT), SMARCB1‐mutant: A clinical and histopathological distinct entity showing epigenetic similarity with ATRT‐MYC (2022) (3)
- Design and operation of insect cell bioreactors for continuous production of baculovirus recombinant proteins. (1990) (3)
- Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma (2015) (2)
- Subject Index, Vol. 77, 1997 (1997) (2)
- P04.01RELA FUSION DEFINES CLINICOPATHOLOGIC SUBSETS OF SUPRATENTORIAL EPENDYMOMA: A STUDY FROM THE COLLABORATIVE EPENDYMOMA RESEARCH NETWORK (2014) (2)
- CNS AT/RTs are a Heterogeneous Entity That Comprises Subgroups with Distinct Molecular Profiles (2014) (2)
- ATRT-11. MOLECULAR SUBGROUPS OF ATYPICAL TERATOID/RHABDOID TUMOR (ATRT): TOWARDS A CONSENSUS (2018) (2)
- Spatial Dissection of Invasive Front from Tumor Mass Enables Discovery of Novel microRNA Drivers of Glioblastoma Invasion (2021) (2)
- SMARCB1-deficient and SMARCA4-deficient Malignant Brain Tumors With Complex Copy Number Alterations andTP53Mutations May Represent the First Clinical Manifestation of Li-Fraumeni Syndrome. (2022) (2)
- Expression of BARHL 1 in medulloblastoma is associated with prolonged survival in mice and humans (2011) (2)
- Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles (2016) (2)
- Molecular progression of SHH-activated medulloblastomas (2019) (2)
- Dynamic modeling of the baculovirus infection process in continuous insect-cell reactors. (1990) (2)
- PDCT-05. MOLECULAR DIAGNOSTICS REVEAL 60% HIGHER SURVIVAL FOR MOLECULARLY-VERIFIED VERSUS HISTOPATHOLOGICALLY-DIAGNOSED PEDIATRIC SUPRATENTORIAL CENTRAL NERVOUS SYSTEM EMBRYONAL TUMORS AND PINEOBLASTOMAS; A REPORT FROM THE CHILDREN’S ONCOLOGY GROUP ACNS0332 TRIAL (2017) (2)
- Molecular subtypes in medulloblastoma: an International meta-analysis for profiles, genetic aberrations, clinicopathological features AND SURVIVAL (2011) (2)
- Comparison of transcriptome profiles between medulloblastoma primary and recurrent tumors uncovers novel variance effects in relapses (2023) (2)
- Arsenic Trioxide Inhibits Tumor Cell Growth in Malignant Rhabdoid Tumor Cell In Vitro and In Vivo by Targeting Overexpressed Gli1 (2014) (2)
- EMBR-04. WHAT THE FOX SAY? A MOLECULAR ANALYSIS OF FOXR2 IN PEDIATRIC BRAIN TUMORS (2018) (2)
- EphB1 Inhibits Migration and Proliferation of Medulloblastoma Tumor Cells and Sensitizes Them to Ionizing Radiation by Mediating a G1 Arrest (2014) (1)
- Retinoblastoma binding protein 4 maintains cycling neural stem cells and prevents DNA damage and Tp53-dependent apoptosis in rb1 mutant neural progenitors (2018) (1)
- A synergistic interaction between HDAC‐ and PARP inhibitors in childhood tumors with chromothripsis (2022) (1)
- EPN-30YAP1-MAMLD1 FUSIONS ALONE ARE SUFFICIENT TO FORM SUPRATENTORIAL EPENDYMOMA-LIKE TUMORS IN MICE (2016) (1)
- Modelling of the baculovirus infection process in insect-cell reactor configurations. (1996) (1)
- EPEN-39. CLINICAL STRATIFIED TREATMENT OF LOCALIZED PEDIATRIC INTRACRANIAL EPENDYMOMA WITH COMBINED LOCAL IRRADIATION AND CHEMOTHERAPY WITHIN THE PROSPECTIVE, MULTICENTER E-HIT TRIAL – THE MOLECULAR SUBGROUP MATTERS (2020) (1)
- PNR-33MOLECULAR RE-EVALUATION OF INSTITUTIONALLY DIAGNOSED CNS-PNETS: CLINICAL CONSEQUENCES OF CONFINED DIAGNOSTIC GROUPS (2016) (1)
- Baculovirus DNA replication: relatedness with herpes viruses. (1994) (1)
- Cellular mRNA signals in human kidney tumors (2020) (1)
- AT-13THE EU-RHAB EXPERIENCE: CLINICAL, GENETIC AND SURVIVAL DATA DEFINE A STANDARD OF CARE AND ARE THE BASIS FOR CLINICAL TRIALS (2016) (1)
- OMICS AND PROGNSTIC MARKERS (2013) (1)
- MOLECULAR (RE-)CLASSIFICATION OF CNS-PRIMITIVE NEUROECTODERMAL TUMORS (2014) (1)
- OS6.1 Molecular characterization of astroblastoma (2016) (1)
- OS5.2 FGFR a novel target in malignant pediatric ependymoma (2018) (1)
- Multispectral confocal 3D imaging of intact healthy and tumor tissue using mLSR-3D (2022) (1)
- Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial ependymoma (2021) (1)
- Abstract 3458: Role of the EphB1 gene in mediating migration, proliferation, and radiosensitization of medulloblastoma cells (2014) (1)
- Abstract 1424: KCNJ2 comprises a marker of poor prognosis and a therapeutic target in non-WNT/non-SHH medulloblastoma (2012) (1)
- Corrigendum to: Molecular subgrouping of atypical teratoid/rhabdoid tumors—a reinvestigation and current consensus (2020) (1)
- Abstract 4872: ICGC PedBrain Tumor - Next-generation sequencing identifies novel subgroup-specific mutations and copy number aberrations in medulloblastoma (2012) (1)
- ATRT-09. WHOLE GENOME AND EPIGENOME CHARACTERIZATION LINKS ATRT-MYC TO A SUBGROUP OF RENAL RHABDOID TUMORS (2018) (1)
- ETMR-03. THE ROLE OF FOXR2 IN PEDIATRIC BRAIN CANCER (2020) (1)
- Abstract 2492: Integrated genomics on molecular subgroups in medulloblastoma (2012) (1)
- Abstract 5050: KCNJ2 constitutes a marker and therapeutic target of high-risk medulloblastomas. (2013) (1)
- MBCL-21. EARLY CHILDHOOD MEDULLOBLASTOMA: SUBGROUP-SPECIFIC SURVIVAL IN PATIENTS TREATED WITH SYSTEMIC CHEMOTHERAPY AND INTRAVENTRICULAR MTX TO AVOID CRANIOSPINAL RADIOTHERAPY (2018) (1)
- PATH-16. HISTOPATHOLOGICAL EPENDYMOMA VARIANTS ARE ASSOCIATED WITH DISTINCT CLINICAL PARAMETERS AND DNA METHYLATION PATTERNS (2019) (1)
- Predictive modeling of resistance to SMO inhibition in a patient-derived orthotopic xenograft model of SHH medulloblastoma (2022) (1)
- EPEN-24. YAP1 FUSION PROTEINS MEDIATE ONCOGENIC ACTIVITY IN EPENDYMOMA VIA INTERACTION WITH TEAD TRANSCRIPTION FACTORS (2018) (1)
- Interrogating the enhancer landscape of intracranial ependymomas: perspectives for precision medicine (2018) (1)
- A synergistic interaction between HDAC- and PARP inhibitors in childhood tumors with chromothripsis (2021) (1)
- The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells (2013) (1)
- Primary cilia contribute to the aggressiveness of atypical teratoid/rhabdoid tumors (2022) (1)
- EPEN-06. YAP1 SUBGROUP SUPRATENTORIAL EPENDYMOMA REQUIRES TEAD AND NUCLEAR FACTOR I-MEDIATED TRANSCRIPTIONAL PROGRAMS FOR TUMORIGENESIS (2019) (1)
- Abstract LB-384: Targeting overexpressed Aurora kinases in childhood medulloblastoma: Antiproliferative effects of small molecule inhibitors ZM44739, VX680 and shRNA (2010) (1)
- Gene expression profiling of Group 3 medulloblastomas defines a clinically tractable stratification based on KIRREL2 expression (2022) (1)
- Abstract 1446: Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem (2012) (1)
- Predisposition of Wingless Subgroup Medulloblastoma for Primary Tumor Hemorrhage. (2019) (1)
- LAB-PEDIATRICS LABORATORY RESEARCH (2012) (1)
- ETMR-14. TREATMENT OF EMBRYONAL TUMOURS WITH MULTILAYERED ROSETTES (ETMR) WITH CARBOPLATIN-ETOPOSIDE INDUCTION AND TANDEM HIGH-DOSE CHEMOTHERAPY WITHIN THE PROSPECTIVE HIT-TRIALS AND REGISTRIES (2020) (1)
- Author Correction: Pan-cancer analysis of whole genomes (2023) (1)
- Prognostic value and functional consequences of cell cycle inhibitor p27Kip1 loss in medulloblastoma (2013) (1)
- TB-17A COMPREHENSIVE PAN-CANCER ANALYSIS OF CHILDHOOD MALIGNANCIES (2016) (1)
- GE-07DNA METHYLATION IN MEDULLOBLASTOMA AND MOLECULAR DIAGNOSTICS OF BRAIN TUMORS. (2015) (0)
- TMOD-02. GEBTO: GENETICALLY ENGINEERED BRAIN TUMOR ORGANOIDS AS A NOVEL PRECLINICAL MODEL (2021) (0)
- QOL-13. NEUROCOGNITIVE OUTCOMES ACCORDING TO RISK-ADAPTED TREATMENT REGIMENS FOR CHILDREN OLDER THAN 4 WITH MEDULLOBLASTOMA AND POSTERIOR FOSSA EPENDYMOMA – RESULTS OF THE HIT2000 TRIAL (2020) (0)
- ATRT-10. Single-cell transcriptional profiling of ATRTs reveals heterogeneous signatures of tumor and non-malignant cell populations (2022) (0)
- ATRT-07. TARGETING PRIMARY CILIOGENESIS IN ATYPICAL TERATOID/RHABDOID TUMORS (2019) (0)
- MODL-02. TARGETING REPLICATION STRESS IN PEDIATRIC BRAIN TUMORS (2020) (0)
- MBRS-65. CHEMI-GENOMIC ANALYSIS OF PATIENT-DERIVED XENOGRAFTS TO IDENTIFY PERSONALIZED THERAPIES FOR MEDULLOBLASTOMA (2016) (0)
- Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis (2018) (0)
- Abstract 2491: Molecular and clinical characterization of the new WHO entity ‘Astroblastoma, MN1 altered’ and its molecular subgroups (2022) (0)
- Abstract 3089: (Epi)genetic profiling enables molecular re-classification of CNS-primitive neuroectodermal tumors (2014) (0)
- IMMU-04. Transcriptional analysis reveals distinct microenvironmental subgroups across pediatric nervous system tumors (2022) (0)
- MODL-29. Molecular Landscape of a comprehensive panel of pediatric brain cancer Patient-derived orthotopic xenograft (PDOX) models inform unique targets for drug responsiveness (2022) (0)
- Abstract 3101: Precise matching of medulloblastoma mouse models to their human counterparts (2014) (0)
- CS-16THE eEF2 KINASE IS CRITICAL FOR BRAIN TUMOURS ADAPTATION TO METABOLIC STRESS. (2014) (0)
- EPEN-04. CXorf67 MIMICS ONCOGENIC HISTONE H3 K27M MUTATIONS AND FUNCTIONS AS INTRINSIC INHIBITOR OF PRC2 FUNCTION IN AGGRESSIVE POSTERIOR FOSSA EPENDYMOMA (2019) (0)
- Molecular Heterogeneity Among Pediatric Posterior Fossa Ependymomas (2017) (0)
- TMOD-11. HUMAN STEM CELL BASED MODEL OF MEDULLOBLASTOMA (2017) (0)
- INSP-15. ITCC-P4: A sustainable platform of molecularly well-characterized PDX models of pediatric cancers for high throughputin vivo testing (2022) (0)
- Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation (2021) (0)
- Abstract 3807: Integrative genomic profiling of pilocytic astrocytomas reveals location specific differential methylation and expression of brain developmental genes. (2013) (0)
- Loss of nuclear envelope phosphatase CTDNEP1 drives aggressive medulloblastoma by triggering MYC amplification and genomic instability (2021) (0)
- Author Correction: Inferring structural variant cancer cell fraction (2022) (0)
- AT-11CRIBRIFORM NEUROEPITHELIAL TUMOR (CRINET): MOLECULAR CHARACTERIZATION OF A SMARCB1-DEFICIENT NON-RHABDOID TUMOR WITH FAVORABLE LONG-TERM OUTCOME (2016) (0)
- The Medulloblastoma Methylome Reveals New Epigenetic Regulatory Mechanisms (2013) (0)
- EPEN-23. Interaction of epigenetic regulation and telomerase re-activation in high-risk ependymoma (2022) (0)
- PNR-09EVALUATION OF AGE-DEPENDENT TREATMENT STRATEGIES FOR CHILDREN AND YOUNG ADULTS WITH PINEOBLASTOMA: ANALYSIS OF POOLED SIOP-E AND HEAD START DATA (2016) (0)
- Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability (2023) (0)
- Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors (2018) (0)
- CSIG-15. PROTEOMIC AND PHOSPHOPROTEOMIC ANALYSIS OF HUMAN MEDULLOBLASTOMA REVEALS DISTINCT ACTIVATED PATHWAYS BETWEEN SUBGROUPS (2017) (0)
- Preclinical evaluation and translational consequences of EZH2-inhibition in malignant brain tumors (2015) (0)
- EPEN-04. ONCOGENIC 3D TUMOR GENOME ORGANIZATION IDENTIFIES NEW THERAPEUTIC TARGETS IN EPENDYMOMA (2020) (0)
- EPEN-03. USP7 is an interaction partner of EZHIP and potential druggable target in PFA ependymomas (2022) (0)
- A biobank of patient-derived pediatric brain tumor models (2018) (0)
- PCLN-06. NOVEL TUMOR-DERIVED MODELS OF CNS HGNET-BCOR PROVIDE INSIGHTS INTO UNDERLYING MOLECULAR MECHANISMS AND INNOVATIVE THERAPEUTIC OPTIONS (2018) (0)
- Interference with the function of MYC – novel insights into the consequences of class I HDAC inhibition in Group 3 Medulloblastoma (2017) (0)
- ETMR-06. Molecular and clinical characteristics of CNS tumors withBCOR(L1) fusion/internal tandem duplication (2022) (0)
- Subgroup-specific prognostic signaling and metabolic pathways in pediatric medulloblastoma (2019) (0)
- MB-18DYSFUNCTION OF THE CHROMATIN REMODELER Chd7 CAUSES ABNORMAL CEREBELLAR DEVELOPMENT AND ACCELERATES MEDULLOBLASTOMA FORMATION. (2016) (0)
- Role of the LIM domain binding protein LDB1 and the LIM only factor LMO4 in SHH subgroup medulloblastoma (2014) (0)
- MBRS-07. BCOR LOSS IMPACTS SHH MEDULLOBLASTOMA FORMATION VIA TRANSCRIPTIONAL UP-REGULATION OF Igf2 (2018) (0)
- Abstract 825: Wnt/beta-catenin signaling regulates the expression of O6-methylguanine DNA-methyltransferase in cancer cells: a new strategy to overcome resistance for DNA alkylators in cancer therapy (2012) (0)
- Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities. (2023) (0)
- Mapping the single cell transcriptome reveals the cellular composition of ATRT subgroups (2019) (0)
- Abstract 3886: 3D genome conformation analysis in ST-EPN-ZFTA ependymoma identifies RCOR2 as a potential target (2022) (0)
- TBIO-05. R-loops in pediatric brain tumors (2022) (0)
- MBCL-40. UNFAVORABLE CLINICAL COURSE OF A WNT-ACTIVATED MEDULLOBLASTOMA (2018) (0)
- EPEN-21. IMPAIRED NEURONAL-GLIAL FATE SPECIFICATION IN PEDIATRIC EPENDYMOMA REVEALED BY SINGLE-CELL RNA-SEQ (2020) (0)
- Abstract A07: Molecular characterization of patient-derived xenograft models of pediatric brain tumors (2016) (0)
- EPEN-07. OVEREXPRESSION AND MUTATIONS OF CXORF67 IN ‘INFANT-TYPE’ POSTERIOR FOSSA TYPE-A (PFA) EPENDYMOMAS (2018) (0)
- ATRT-07. Low-grade diffusely infiltrative tumor, SMARCB1-mutant: a clinical and histopathological distinct entity showing epigenetic similarity with ATRT-MYC (2022) (0)
- OS02.2 Functional investigation of recurrent genetic aberrations in newly identified pediatric brain tumor entities. (2017) (0)
- EPCO-47. ITCC-P4: GENOMIC PROFILING AND ANALYSES OF PEDIATRIC PATIENT TUMOR AND PATIENT-DERIVED XENOGRAFT (PDX) MODELS FOR HIGH THROUGHPUT IN VIVO TESTING (2022) (0)
- Abstract A25: Evaluation of Drug Disposition in Supratentorial Ependymoma (2020) (0)
- MBCL-42. SECOND GENERATION MOLECULAR SUBGROUPING OF MEDULLOBLASTOMA: TOWARDS A WORKING CONSENSUS OF GROUP 3/4 SUBTYPES (2018) (0)
- Clinicopathological features of medulloblastoma: an overview with an emphasis on molecular biology. (2007) (0)
- Dysregulated expression of histone deacetylases in medulloblastoma - potential targets for selective inhibitor treatment (2013) (0)
- Abstract 3093: Unravelling the biology of aggressive and therapy-resistant embryonal tumors with multilayered rosettes (ETMR) (2014) (0)
- EPEN-10. Elucidating the biological difference between pediatric supratentorial ependymomas using genetically engineered brain tumor organoids. (2022) (0)
- Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours (2019) (0)
- Abstract A1-59: Multiple mechanisms of MYCN dysregulation in Wilms tumor (2015) (0)
- glioblastomas display improved survival and reduced NADP + -dependent IDH activity ex vivo (2009) (0)
- Em-24. Telomerase Inhibition Induces Growth Arrest in Paediatric Ependymoma (2012) (0)
- Abstract 2891: Landscape of infiltrating immune repertoire in pediatric solid tumors (2019) (0)
- Transcriptome analysis stratifies second-generation non-WNT/non-SHH medulloblastoma subgroups into clinically tractable subtypes. (2023) (0)
- PNR-12GENOME-WIDE PROFILING OF EMBRYONAL TUMORS WITH MULTILAYERED ROSETTES (ETMR) (2016) (0)
- Abstract PR08: Overexpression and mutations of CXorf67 in “infant-type” posterior fossa type-A ependymomas (2018) (0)
- Germline Elongator mutations in Sonic Hedgehog medulloblastoma (2020) (0)
- PCM-16MOLECULAR CHARACTERIZATION OF ORTHOTOPIC PATIENT-DERIVED XENOGRAFT MODELS OF PEDIATRIC BRAIN TUMORS (2016) (0)
- MODL-01. Targeting replication stress in pediatric brain tumors (2022) (0)
- EPEN-28. HETEROGENEITY WITHIN THE PFB EPENDYMOMA SUBGROUP (2018) (0)
- AT-03ATYPICAL TERATOID/RHABDOID TUMOUR IS A GENETICALLY HOMOGENEOUS BUT EPIGENETICALLY HETEROGENEOUS DISEASE THAT IS DEFINED BY SUBGROUP SPECIFIC SUPER-ENHANCERS (2015) (0)
- ETMR-17. SINGLE-CELL TRANSCRIPTOME ANALYSIS OF ETMR PATIENT SAMPLES (2020) (0)
- The KidsCancerKinome - Validation of Drug Targets for High Risk Childhood Cancers (2011) (0)
- Abstract 1428: A CpG island methylator phenotype defines a clinically aggressive subgroup of posterior fossa ependymoma (2012) (0)
- Abstract B27: A link between small noncoding RNAs and mRNA translation elongation: The let7-eEF2K axis in pediatric tumor adaptation to nutrient deprivation (2020) (0)
- MBRS-51. MUTATIONS IN BRPF1 FOUND IN SHH MEDULLOBLASTOMA PREVENT INTERACTION WITH TP53 AND LEADS TO RADIORESISTANCE IN VITRO (2020) (0)
- Abstract A25: Establishment of orthotopic patient-derived xenograft models of pediatric brain tumors – the Heidelberg experience (2016) (0)
- PTPS-11ATYPICAL TERATOID/RHABDOID TUMOUR IS AN EPIGENETICALLY HETEROGENEOUS DISEASE CHARACTERIZED BY SUBGROUP SPECIFIC SUPER-ENHANCERS (2015) (0)
- Targeting PLK1 and Aurora kinases in medulloblastoma (2012) (0)
- LGG-11. REGULATION OF ONCOGENE-INDUCED SENESCENCE IN PILOCYTIC ASTROCYTOMA (2018) (0)
- THER-02. TARGETING DNA DAMAGE REPAIR IN MYC-DRIVEN PEDIATRIC BRAIN TUMORS (2019) (0)
- WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma (2014) (0)
- PL-01. IDENTIFICATION OF NOVEL FUSION GENES IN PEDIATRIC HIGH-GRADE GLIOMA (2012) (0)
- Abstract 1673: Establishment and characterization of pediatric brain tumor models in an orthotopic mouse model (2022) (0)
- Targeting MYC/HDAC2 interaction in Group 3 medulloblastoma – rationales for an innovative therapeutic approach (2015) (0)
- EPEN-18. Oncogenic 3D genome conformations identify novel therapeutic targets in ependymoma (2020) (0)
- Abstract C115: The KidsCancerKinome: Validation of Aurora kinases as potential drug targets in pediatric tumors (2009) (0)
- Monoclonal Antibodies MRP2, MRP3, MRP5, and MDR3 P-Glycoprotein with a Panel of Specific Detection of Multidrug Resistance Proteins MRP1, (2013) (0)
- Abstract B71: Molecular heterogeneity and novel oncogenic fusions in RELA- and YAP1-negative supratentorial ependymoma (2020) (0)
- ETMR-12. Novel cell models of CNS tumors with BCOR fusion or internal tandem duplication suggest FGFR and PDGFR as promising therapy targets (2022) (0)
- EPEN-23. MOLECULAR HETEROGENEITY AMONG PEDIATRIC POSTERIOR FOSSA EPENDYMOMA (2017) (0)
- Abstract A20: hTERT promoter hypermethylation is a cancer signature which predicts survival and response to targeted therapy in pediatric nervous system tumors (2014) (0)
- PDTM-49. GLOBAL REDUCTION IN H3K27me3, SIMILAR TO H3K27M MUTANT GLIOMAS, IS A MOLECULAR SURROGATE FOR PEDIATRIC POSTERIOR FOSSA- GROUP A EPENDYMOMAS (2017) (0)
- EMBR-01. MOLECULAR AND CLINICAL HETEROGENEITY IN HISTOLOGICALLY-DIAGNOSED CNS-PNET PATIENTS PROSPECTIVELY TREATED AS A SINGLE ENTITY: A REPORT FROM THE CHILDREN’S ONCOLOGY GROUP ACNS0332 TRIAL (2018) (0)
- Abstract A39: Molecular characterization of ETMRs reveals role for R-loop mediated genomic instability and new treatment options (2020) (0)
- MB-46PROGNOSTIC RELEVANCE OF EPIGENETIC/BIOLOGICAL SUBGROUPS AND MYCC/MYCN GENE AMPLIFICATION IN A HOMOGENOUSLY TREATED METASTATIC MEDULLOBLASTOMA HIT2000 COHORT AGED 4-21 YEARS (2016) (0)
- ATRT-13. An integrative analysis of the ATRT proteome unravels novel drug targets and refines molecular subgrouping (2022) (0)
- ETMR-11. Transcriptional changes upon knockdown of alteredBCOR/BCORL1 transcripts in preclinical models of CNS embryonal tumors with BCOR-related alterations (2022) (0)
- RARE-15. Astroblastoma, MN1 altered comprises two molecularly and clinically distinct subgroups defined by the fusion partners BEND2 and CXXC5 (2022) (0)
- PDTM-13. OVEREXPRESSION OF MYC ALONE IS SUFFICIENT TO INITIATE GROUP 3 MEDULLOBLASTOMA (2018) (0)
- EPCO-35. SINGLE-CELL RNA-SEQ OF PEDIATRIC EPENDYMOMA REVEALS PROGNOSTIC IMPACT OF IMPAIRED NEURONAL-GLIAL FATE SPECIFICATION (2020) (0)
- BIOM-35. CLINICALLY TRACTABLE OUTCOME PREDICTION OF GROUP 3/4 MEDULLOBLASTOMA BASED ON TPD52 IMMUNOHISTOCHEMISTRY: A MULTICOHORT STUDY (2021) (0)
- Abstract 3571: The ITCC-P4 sustainable platform of fully characterized PDXs supports the preclinical proof-of-concept drug testing of high-risk pediatric tumor models (2023) (0)
- Comparative integrative analysis of primary and relapsed atypical teratoid/rhabdoid tumors (AT/RTs) (2018) (0)
- Abstract 4594: Recurrent FGFR1 hotspot mutations represent a novel therapeutic target in childhood astrocytoma. (2013) (0)
- AT-10ATYPICAL TERATOID RHABDOID TUMORS AND POORLY DIFFERENTIATED CHORDOMAS: DISTINCT MOLECULAR ENTITIES WITH SMARCB1/INI1 LOSS AND DISMAL PROGNOSIS (2016) (0)
- Abstract 1352: Inactivation of factors of DNA double-strand break repair by homologous recombination or non-homologous end-joining leads to frequent catastrophic genomic events in murine and human tumors (2018) (0)
- Abstract 1935: Molecular characterization of orthotopic patient-derived xenograft models of pediatric brain tumors (2017) (0)
- The molecular landscape of ETMR at diagnosis and relapse (2019) (0)
- MEDB-41. Identifying a subgroup of patients with early childhood sonic hedgehog-activated medulloblastoma with unfavorable prognosis after treatment with radiation-sparing regimens including intraventricular methotrexate (2022) (0)
- GENE-15. TARGETING OF EPENDYMOMA AS INFORMED BY ONCOGENIC 3D GENOME ORGANIZATION (2019) (0)
- EPEN-05. CXorf67 EXPRESSION IS A PUTATIVE DRIVER OF PFA EPENDYMOMA (2018) (0)
- Abstract 4591: Whole genome sequencing of SHH medulloblastomas predicts molecular groups of responders and non-responders to SMO-inhibition . (2013) (0)
- Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers (2023) (0)
- Targeting class I histone deacetylases in high risk medulloblastoma – analysis of molecular mechanisms and translational implications (2014) (0)
- MBCL-28. PREDISPOSITION OF WNT-ACTIVATED MEDULLOBLASTOMA FOR PRIMARY INTRATUMORAL HEMORRHAGE (2018) (0)
- Abstract 4124: YAP1 fusion proteins mediate oncogenic activity in ependymoma via interaction with TEAD transcription factors (2018) (0)
- Author Correction: The evolutionary history of 2,658 cancers (2023) (0)
- MEDU-21. LOSS OF THE TRANSCRIPTIONAL CO-REPRESSOR BCOR LEADS TO OVEREXPRESSION OF THE GROWTH FACTOR IGF2 AND SHH MEDULLOBLASTOMA TUMOR FORMATION (2019) (0)
- MODL-04. Drug screening in Disorders with Abnormal DNA Damage Response/Repair (DADDR) andin vivo validation (2022) (0)
- EPEN-03. ZFTA/C11ORF95 FUSIONS DRIVE SUPRATENTORIAL EPENDYMOMA VIA SHARED ONCOGENIC MECHANISMS (2021) (0)
- PROLONGED SURVIVAL ASSOCIATED WITH THE USE OF INTRAOPERATIVE CARMUSTINE WAFERS ( GLIADEL w ) IN A PAEDIATRIC PATIENT WITH RECURRENT HIGH GRADE GLIOMA (2012) (0)
- The potential of PARP as a therapeutic target across pediatric solid malignancies (2023) (0)
- Targeting the interaction of HDAC2 and MYC in Group 3 medulloblastoma (2016) (0)
- EMBR-01. CLASS I HDAC INHIBITORS AND PLK1 INHIBITORS SYNERGIZE IN MYC-AMPLIFIED MEDULLOBLASTOMA (2021) (0)
- Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors (2020) (0)
- EPN-12PEDIATRIC SUPRATENTORIAL EPENDYMOMA: COMPARISON BETWEEN IMMUNOHISTOCHEMISTRY, FISH AND DNA METHYLATION ANALYSIS FOR RELA REARRANGEMENT AND HISTOLOGICAL CORRELATION (2016) (0)
- ETMR-08. INTERNATIONAL CONSENSUS PROTOCOL FOR EMBRYONAL TUMOR WITH MULTILAYER ROSETTES (2020) (0)
- Abstract A1-67: Prognostic significance of copy number aberrations in Wilms tumor (2015) (0)
- EMBR-10. GENOMIC COMPLEXITY AND EVOLUTION OF EMBRYONAL TUMORS WITH MULTILAYERED ROSETTES (ETMR) (2018) (0)
- PDTM-23. THE ACTIVE REGULATORY LANDSCAPE OF EPENDYMAL TUMORS (2017) (0)
- PATH-03. Clinically Tractable Outcome Prediction of Group 3/4 Medulloblastoma Based on TPD52 Immunohistochemistry: a Multicohort Study (2022) (0)
- MBCL-21. GERMLINE ELONGATOR MUTATIONS IN SONIC HEDGEHOG MEDULLOBLASTOMA (2020) (0)
- Abstract PR08: mSWI/SNF (BAF) complexes facilitate decatentation of DNA by topoisomerase IIα (2013) (0)
- EPND-01. THE ACTIVE REGULATORY LANDSCAPE OF EPENDYMAL TUMORS. (2017) (0)
- Nestin protein expression is an independent prognostic marker in ependymoma and discriminates WHO II ependymoma with poor outcome (2012) (0)
- Assignment of the canalicular multiorganic anion transporter (cMOAT) gene to human chromosome 10q24 and mouse chromosome 19D2 (1997) (0)
- Abstract 3172: Targeting genomic instability in embryonal tumors with multilayered rosettes (ETMR) (2018) (0)
- ATRT-07. MURINE SOX2-POSITIVE EARLY PRECURSOR CELLS GIVE RISE TO RHABDOID TUMORS WITH FEATURES OF THE HUMAN ATRT-MYC GROUP (2018) (0)
- EPEN-18. CROSS-SPECIES GENOMICS IDENTIFIES GLI2 AS AN ONCOGENE OF C11orf95 FUSION-POSITIVE SUPRATENTORIAL EPENDYMOMA (2020) (0)
- Abstract B37: Chemi-genomic analysis of patient-derived xenografts to identify personalized therapies for medulloblastoma (2016) (0)
- ATRT-34. TARGETING PRIMARY CILIOGENESIS IN ATYPICAL TERATOID/RHABDOID TUMORS (2018) (0)
- Defective interference during continuous production of baculoviruses in bioreactors. (1991) (0)
- MEDB-04. Young children with metastatic medulloblastoma: frequent requirement for radiotherapy in children with non-WNT/non-SHH medulloblastoma despite highly intensified chemotherapy – Results of the MET-HIT2000-BIS4 trial (2022) (0)
- Abstract 3660: A link between miRNAs and mRNA translation elongation: The let7-eEF2K axis in MYC-driven pediatric tumors adaptation to nutrient deprivation (2019) (0)
- HGG-50. Specific sensitivity of pediatric high-grade glioma with ATRX inactivation to PARP inhibitor combinations (2022) (0)
- PDTM-46. TARGETING METABOLIC ADAPTATION IN MYC DRIVEN PEDIATRIC NEURONAL TUMORS (2017) (0)
- Abstract 2588: Targeting overexpressed PLK1 and Aurora kinases in childhood medulloblastoma (2011) (0)
- GENE-02. CHROMOSOME CONFORMATION ANALYSIS OF EPENDYMOMA IDENTIFIES PUTATIVE TUMOR DEPENDENCY GENES ACTIVATED BY DISTAL ONCOGENIC ENHANCERS (2019) (0)
- GENT-25. hTERT PROMOTER HYPERMETHYLATION IS ASSOCIATED WITH INFAVOURABLE MOLECULAR SUBTYPES AND TELOMERASE RE-ACTIVATION IN PEDIATRIC EPENDYMOMA (2016) (0)
- MBCL-44. THE MOLECULAR AND CLINICAL LANDSCAPE OF INFANT MEDULLOBLASTOMA (iMB): RESULTS AND MOLECULAR ANALYSIS FROM A PROSPECTIVE, MULTICENTER PHASE II TRIAL (SJYC07) (2018) (0)
- TB-06 MOLECULAR MECHANISM OF BRAIN TUMOUR FORMATION DRIVEN BY SUPRATENTORIAL EPENDYMOMA-SPECIFIC YAP1 FUSION GENES (2019) (0)
- [Growth and transformation of tissue elements in the cerebrovascular plexus in tissue culture]. (1970) (0)
- IMMU-14. COMPUTATIONAL DECONVOLUTION OF TUMOR-INFILTRATING IMMUNE COMPONENTS IN PEDIATRIC NERVOUS SYSTEM TUMORS (2021) (0)
- EPCO-27. SINGLE-CELL ANALYSIS OF ETMR PATIENT SAMPLES LINKS TRANSCRIPTIONAL PHENOTYPES TO GENETIC DRIVER ALTERATIONS AND INFORMS NOVEL THERAPEUTIC STRATEGIES (2021) (0)
- MBRS-57. TARGETING METABOLIC ADAPTATION IN MYC/MYCN AMPLIFIED PEDIATRIC MEDULLOBLASTOMA AND NEUROBLASTOMA (2018) (0)
- TMOD-41. TWO NOVEL SETS OF PATIENT DERIVED ORTHOTOPIC XENOGRAFT MOUSE MODELS (PDOX) ESTABLISHED FROM MATCHING PRIMARY AND RECURRENT PEDIATRIC BRAIN TUMORS (2017) (0)
- P02.07 Characterization of the tumor immune microenvironment of pediatric posterior fossa A ependymomas (2021) (0)
- Recurrent MET fusion genes represent a druggable target in paediatric glioblastoma 1 2 (2016) (0)
- PDTM-17. MiR-126, miR-369-5p AND miR-487b DRIVE PEDIATRIC GLIOBLASTOMA INVASION VIA KCNA1 (2019) (0)
- TMOD-05. MOLECULAR CHARACTERIZATION OF ORTHOTOPIC PATIENT-DERIVED XENOGRAFT MODELS OF PEDIATRIC BRAIN TUMORS AND THEIR USE IN PRECLINICAL EXPERIMENTS. (2017) (0)
- MEDU-11. MOLECULAR CHARACTERIZATION OF ETMRs REVEALS A ROLE FOR R-LOOP MEDIATED CHROMOSOMAL INSTABILITY (2019) (0)
- ETMR-13. NFI GENES IN ETMR TUMORIGENESIS AND NEURODEVELOPMENT (2020) (0)
- ATRT-05. USING DROSOPHILA TO EXPLORE THE FUNCTIONAL RELEVANCE OF GENES AFFECTED BY EPIGENETIC ALTERATIONS IN ATYPICAL TERATOID/RHABDOID TUMORS (AT/RT) (2018) (0)
- Abstract 3084: Epigenetic deregulation in H3.3-K27M mutant pediatric high-grade gliomas (2014) (0)
- Prognostic value and functional consequences of cell cycle inhibitor p27Kip1 loss in medulloblastoma (2013) (0)
- CNS tumor with EP300::BCOR fusion: discussing its prevalence in adult population (2023) (0)
- The Pediatric Brain Tumor Preclinical Testing Program: update and perspectives (2013) (0)
- Abstract 2751: Wnt/β-catenin regulates the expression of MGMT through TCF/LEF transcription: new strategy for DNA alkylators in cancer therapy. (2013) (0)
- ATRT-28. SINGLE NUCLEI SEQUENCING REVEALS THE DIFFERENT PHENOTYPIC COMPOSITION OF THE ATRT SUBGROUPS (2020) (0)
- ETMR-09.In vitro modelling of embryonal tumors with multilayered rosettes (ETMR) and other novel brain tumor types. (2022) (0)
- ATRT-24. CHROMATIN SEGMENTATION IN ATRT REVEALS AN IMPORTANT ROLE FOR RESIDUAL SWI/SNF MEMBERS (2018) (0)
- Author Correction: Patterns of somatic structural variation in human cancer genomes (2020) (0)
- MBRS-12. INTERFERENCE WITH THE FUNCTION OF MYC IN GROUP 3 MEDULLOBLASTOMA (2018) (0)
- MPTH-26MOLECULAR REFINEMENT OF PEDIATRIC POSTERIOR FOSSA EPENDYMOMA (2015) (0)
- ATRT-09. INTEGRATIVE ANALYSES OF GENE REGULATORY LANDSCAPES REVEAL RHABDOID TUMOR SUBGROUPS WITH POSSIBLE IMMUNE MODULATION THROUGH EPIGENETIC DYSREGULATION (2019) (0)
- PCLN-05. A BIOBANK OF PATIENT-DERIVED MOLECULARLY CHARACTERIZED ORTHOTOPIC PEDIATRIC BRAIN TUMOR MODELS FOR PRECLINICAL RESEARCH (2018) (0)
- Risk prediction in early childhood SHH medulloblastoma treated with radiation-avoiding chemotherapy: Evidence for more than two subgroups. (2023) (0)
- MEDB-14. Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome (2022) (0)
- EMBR-21. CLINICALLY TRACTABLE OUTCOME PREDICTION OF GROUP 3/4 MEDULLOBLASTOMA BASED ON TPD52 IMMUNOHISTOCHEMISTRY: A MULTICOHORT STUDY (2021) (0)
- DDIS-19. USING MATCHED PRIMARY AND RECURRENT PEDIATRIC BRAIN TUMOR ORTHOTOPIC MOUSE MODELS(PDOX) TO ILLUSTRATE THE GENETIC REVOLUTION AND TO INFORM NEW ANTI-RECURRENT PERSONALIZED THERAPIES (2019) (0)
- EMBR-12. IMPROVED DIAGNOSTIC ALGORITHM FOR DIFFERENTIAL DIAGNOSTICS OF CNS EMBRYONAL TUMORS (FORMER CNS-PNET) BY NEUROPATHOLOGICAL RE-EVALUATION OF 256 CASES AND CROSSVALIDATION BY METHYLATION CLASSIFICATION (2018) (0)
- TBIO-02. Mapping the origins of pediatric brain tumors to cell type lineages in the developing cerebellum. (2022) (0)
- Abstract PR06: The immunogenomic landscape of pediatric primary solid tumors (2020) (0)
- MPTH-15MOLECULAR RECLASSIFICATION OF CNS-PRIMITIVE NEUROECTODERMAL TUMORS INTO WELL-KNOWN AND NOVEL TUMOR ENTITIES (2015) (0)
- MBRS-33. RNA-SEQUENCING OF MEDULLOBLASTOMA PATIENT-DERIVED ORTHOTOPIC XENOGRAFT (PDOX) MODELS ENABLES IDENTIFICATION OF BOTH TUMOR AND MICROENVIRONMENT SPECIFIC BIOMARKERS (2018) (0)
- MB-57INTERACTION OF HDAC2 AND MYC IN GROUP 3 MEDULLOBLASTOMA - A NOVEL THERAPEUTIC TARGET. (2016) (0)
- Abstract LB-209: Expression of O6-methylguanine DNA-methyltransferase is regulated by Wnt/β-catenin signalling in cancer cells: A new strategy for DNA alkylators in cancer therapy (2011) (0)
- Implementation of paediatric precision oncology into clinical practice: The Individualized Therapies for Children with cancer program ‘iTHER’ (2022) (0)
- MEDB-52. Organoids as preclinical models to improve and personalize disease outcome for sonic hedgehog medulloblastoma (2022) (0)
- Targeting differentially expressed histone deacetylases in Medulloblastoma – novel approach for treatment of high risk patients (2013) (0)
- Radiosensitivity in brain tumours in children (2004) (0)
- Classifying medulloblastoma into molecular subgroups: Means, motive, and opportunity (2014) (0)
- EP-03MOLECULAR CLASSIFICATION OF EPENDYMAL TUMORS ACROSS ALL CNS COMPARTMENTS, HISTOPATHOLOGICAL GRADES AND AGE GROUPS (2015) (0)
- MBRS-05. A p53 INDEPENDENT MOUSE MODEL OF GROUP 3 MEDULLOBLASTOMA (2018) (0)
- EPEN-08. Single-cell transcriptome analysis defines a tumor-supportive microenvironment and tumor-stroma crosstalk in pediatric ependymoma and medulloblastoma. (2022) (0)
- Abstract 3885: USP7 is an interaction partner of EZHIP and potential druggable target in PFA ependymomas (2022) (0)
- MEDU-20. TARGETING OF MYC BY HDAC INHIBITION IN MYC AMPLIFIED GROUP 3 MEDULLOBLASTOMA. (2017) (0)
- Abstract LB-B23: Medulloblastoma regulatory circuitries reveal subgroup-specific cellular origins (2015) (0)
- MEDB-50. Assessment of cellular radiosensitivity and DNA repair in medulloblastoma cell lines and patient-derivded xenograft slice cultures (2022) (0)
- ATRT-06. CLINICAL AND MOLECULAR RISK FACTORS IN CHILDREN WITH ATYPICAL TERATOID/RHABDOID TUMOUR (AT/RT) - EVIDENCE FROM THE EU-RHAB REGISTRY (2018) (0)
- EPND-02. GENOMIC COPY NUMBER ALTERATIONS IN EPENDYOMOMA. (2017) (0)
- PCM-20PRE-CLINICAL DRUG SCREEN IN A PDX ETMR MOUSE MODEL (2016) (0)
- CBMT-05. ROLE OF THE let7-eEF2K AXIS IN MYC-DRIVEN MEDULLOBLASTOMA ADAPTATION TO NUTRIENT DEPRIVATION (2018) (0)
- EPEN-10. ROLE OF DNA METHYLATION ANALYSIS IN RECURRENT PAEDIATRIC EPENDYMOMA (2018) (0)
- PM-09ESTABLISHMENT AND MOLECULAR CHARACTERIZATION OF PATIENT-DERIVED XENOGRAFT MODELS OF PEDIATRIC BRAIN TUMORS (2015) (0)
- Abstract 3094: Epigenetic classification of ependymal brain tumors across age groups (2014) (0)
- Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples (2020) (0)
- Enhanced Survival of High-Risk Medulloblastoma-Bearing Mice after Multimodal Treatment with Radiotherapy, Decitabine, and Abacavir (2022) (0)
- Otx2 Regulates Cell Cycle Genes in Medulloblastoma (2010) (0)
- MBRS-68. SINGLE NUCLEUS RNA-SEQUENCING DECIPHERS INTRATUMORAL HETEROGENEITY IN MEDULLOBLASTOMA WITH EXTENSIVE NODULARITY (MBEN) (2020) (0)
- GENT-28. THE EPIGENETIC LANDSCAPE OF ATYPICAL TERATOID/ RHABDOID TUMORS REVEALS A REPRESSED METHYLOME AND EPIGENETIC SWITCHES AT SMARCB1 BINDING SITES (2016) (0)
- AI-08SUBGROUP-SPECIFIC DEREGULATION OF COAGULATION AND ANGIOGENIC GENE EXPRESSION PROFILES IN MEDULLOBLASTOMA- EVIDENCE FOR CROSS-TALK BETWEEN GROWTH FACTOR AND COAGULATION PATHWAYS (2014) (0)
- 3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma (2023) (0)
- The Pediatric Brain Tumor Preclinical Testing Program: an update on the current status (2012) (0)
- ATRT-08. SMARCB1- and SMARCA4-deficient malignant brain tumors with complex copy number alterations andTP53 mutations may represent the first clinical manifestation of Li-Fraumeni syndrome (2022) (0)
- THE GENETIC HETEROGENEITY OF POSTERIOR FOSSA EPENDYMOMA (2012) (0)
- 542 Tumour stem cells in oncogenic RAS-dependent rhabdomyosarcoma (2010) (0)
- Abstracts of the 52nd Workshop for Pediatric Research (2017) (0)
- GENT-07. SUBGROUP SPECIFIC ENHANCERS CONTROL DISTINCT REGULATORY CIRCUITRIES IN EPENDYMAL TUMORS (2016) (0)
- MEDB-36. Clinical and molecular heterogeneity withinMYC andMYCN amplified medulloblastoma (2022) (0)
- Abstract SY15-02: Identification of novel oncogenic mechanisms in brain tumors with quiet genomes through mapping the enhancer landscape (2016) (0)
- EPN-07IMPACT OF CHROMOSOMAL ABERRATIONS AND MOLECULAR SUBTYPE ON TELOMERASE ACTIVATION IN PEDIATRIC EPENDYMOMA (2016) (0)
- Transcriptional immunogenomic analysis reveals distinct immunological clusters in pediatric nervous system tumours (2022) (0)
- Integrating Clinical and Molecular Genetic Data in AT/RT - Results from the European Rhabdoid Registry (EU-RHAB) (2016) (0)
- OTME-3. Dissection of the role of stromal microenvironment and tumor-TME crosstalk in pediatric brain cancer (2021) (0)
- ATRT-09. CHROMATIN SEGMENTATION ANALYSES IN ATYPICAL TERATOID/RHABDOID TUMORS REVEAL H3K27ME3-MEDIATED EPIGENETIC SILENCING OF TUMOR SUPPRESSOR GENES AND IDENTIFY A NOVEL ROLE OF EZH2, ASSOCIATED WITH ACTIVE CHROMATIN. (2017) (0)
- MODL-14 Inhibition of cell cycle mechanisms to combat high-risk medulloblastoma (2022) (0)
- SAGE analysis of pediatric tumors identifies new markers and common genetic pathways (2001) (0)
- Abstract 3825: Inhibitory effect of PID1 in medulloblastomas, gliomas and ATRT. (2013) (0)
- EPN-34EPIGENOMIC ANALYSIS OF EPENDYMAL TUMORS IDENTIFIES SUBGROUP SPECIFIC ENHANCERS CONTROLLING DISTINCT REGULATORY CIRCUITRIES (2016) (0)
- EPIG-04THE CHROMATIN LANDSCAPE OF MEDULLOBLASTOMA (2015) (0)
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What Schools Are Affiliated With Marcel Kool?
Marcel Kool is affiliated with the following schools:
