Mutsuo Sekiguchi
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Molecular Biology
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Chemistry Biology
Mutsuo Sekiguchi's Degrees
- PhD Biochemistry University of Tokyo
- Masters Chemistry University of Tokyo
- Bachelors Chemistry University of Tokyo
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(Suggest an Edit or Addition)Mutsuo Sekiguchi's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis (1992) (830)
- Targeted disruption of the Rad51 gene leads to lethality in embryonic mice. (1996) (798)
- Genes to cells: edited by Jun-ichi Tomizawa, Blackwell Science Ltd. Institutional: £218.00 (Europe), £242.00 (Rest of World), US$382.00 (USA and Canada). Individual: £65.00 (Europe), £72.00 (Rest of World), US$114.00 (USA and Canada) ISSN 1356 9597 (1997) (668)
- Regulation and expression of the adaptive response to alkylating agents. (1988) (582)
- Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis. (1993) (405)
- Functional cooperation of MutT, MutM and MutY proteins in preventing mutations caused by spontaneous oxidation of guanine nucleotide in Escherichia coli. (1995) (310)
- Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool. (1992) (292)
- Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase (2001) (292)
- Counteraction by MutT protein of transcriptional errors caused by oxidative damage. (1997) (271)
- Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption. (2003) (226)
- Oxidative nucleotide damage: consequences and prevention (2002) (211)
- Intracellular Localization of 8-Oxo-dGTPase in Human Cells, with Special Reference to the Role of the Enzyme in Mitochondria (*) (1995) (204)
- Isolation and characterization of the active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation. (1987) (203)
- Induction of Phage Formation in the Lysogenic Escherichia coli K-12 by Mitomycin C (1959) (175)
- A new gene (alkB) of Escherichia coli that controls sensitivity to methyl methane sulfonate (1983) (163)
- Generation and elimination of 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate, a mutagenic substrate for DNA synthesis, in human cells. (1995) (155)
- O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis. (1993) (152)
- Mutants of Escherichia coli permeable to actinomycin. (1967) (146)
- Metabolic fate of oxidized guanine ribonucleotides in mammalian cells. (1999) (142)
- Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice. (1997) (141)
- Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion. (1994) (134)
- Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes. (1998) (133)
- T4 endonuclease involved in repair of DNA. (1970) (133)
- Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer (2003) (132)
- THE SYNTHESIS OF MESSENGER RNA WITHOUT PROTEIN SYNTHESIS. II. SYNTHESIS OF PHAGE-INDUCED RNA AND SEQUENTIAL ENZYME PRODUCTION. (1964) (127)
- Three-Dimensional Structure of a DNA Repair Enzyme, 3-Methyladenine DNA Glycosylase II, from Escherichia coli (1996) (119)
- Expression and cloning of complementary DNA for a human enzyme that repairs O6-methylguanine in DNA. (1990) (114)
- Effect of mitomycin C on the synthesis of bacterial and viral deoxyribonucleic acid. (1960) (106)
- A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides (2003) (105)
- Mutations of temperature sensitivity in R plasmid pSC101 (1977) (103)
- Binding capacity of human YB-1 protein for RNA containing 8-oxoguanine. (2002) (102)
- Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides. (2003) (99)
- A specific role of MutT protein: to prevent dG.dA mispairing in DNA replication. (1989) (99)
- Physical association of pyrimidine dimer DNA glycosylase and apurinic/apyrimidinic DNA endonuclease essential for repair of ultraviolet-damaged DNA. (1981) (95)
- Mammalian enzymes for preventing transcriptional errors caused by oxidative damage (2005) (95)
- High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase. (1997) (94)
- Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting. (1997) (94)
- Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates (2012) (92)
- Regulatory mechanisms for induction of synthesis of repair enzymes in response to alkylating agents: ada protein acts as a transcriptional regulator. (1986) (92)
- Structures and functions of DNA glycosylases. (1990) (91)
- Molecular cloning of an activated human oncogene, homologous to v-raf, from primary stomach cancer. (1985) (87)
- Mouse MTH1 Protein with 8-Oxo-7,8-dihydro-2′-deoxyguanosine 5′-Triphosphatase Activity That Prevents Transversion Mutation (1995) (87)
- Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase. (2000) (87)
- Purification and structure of the intact Ada regulatory protein of Escherichia coli K12, O6-methylguanine-DNA methyltransferase. (1985) (86)
- Specific binding of 8-oxoguanine-containing RNA to polynucleotide phosphorylase protein. (2001) (84)
- Multiple enzyme activities of Escherichia coli MutT protein for sanitization of DNA and RNA precursor pools. (2005) (83)
- Age-dependent increases in the oxidative damage of DNA, RNA, and their metabolites in normal and senescence-accelerated mice analyzed by LC-MS/MS: urinary 8-oxoguanosine as a novel biomarker of aging. (2012) (81)
- Proliferative activation of quiescent Rat-1A cells by delta FosB (1993) (79)
- Escherichia coli gene that controls sensitivity to alkylating agents (1978) (79)
- Purification and characterization of normal and mutant forms of T4 endonuclease V. (1982) (77)
- Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability (2005) (77)
- Mutational specificity of the dnaE173 mutator associated with a defect in the catalytic subunit of DNA polymerase III of Escherichia coli. (1991) (76)
- Molecular cloning of AtMMH, an Arabidopsis thaliana ortholog of the Escherichia coli mutM gene, and analysis of functional domains of its product (1998) (75)
- Cloning and characterization of the alkA gene of Escherichia coli that encodes 3-methyladenine DNA glycosylase II. (1984) (74)
- Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes. (2002) (72)
- Structure and expression of the alkA gene of Escherichia coli involved in adaptive response to alkylating agents. (1984) (71)
- Age-Dependent Accumulation of 8-Oxoguanine in the DNA and RNA in Various Rat Tissues (2013) (70)
- Isolation of temperature-sensitive mutants of R plasmid by in vitro mutagenesis with hydroxylamine (1976) (69)
- Purification, structure, and biochemical properties of human O6-methylguanine-DNA methyltransferase. (1990) (68)
- Mechanism of repair of DNA in bacteriophage. II. Inability of ultraviolet-sensitive strains of bacteriophage in inducing an enzyme activity to excise pyrimidine dimers. (1970) (67)
- The selective degradation of phage-induced ribonucleic acid by polynucleotide phosphorylase. (1963) (66)
- Molecular cloning of a human gene that regulates chromosome condensation and is essential for cell proliferation (1986) (66)
- CpG methylation of MGMT and hMLH1 promoter in hepatocellular carcinoma associated with hepatitis viral infection (2003) (64)
- Regulation of Expression of the Human MTH1 Gene Encoding 8-Oxo-dGTPase (1997) (64)
- Mechanism of repair of DNA in bacteriophage. I. Excision of pyrimidine dimers from ultraviolet-irradiated DNA by an extract of T4-infected cells. (1970) (64)
- Human polynucleotide phosphorylase protein in response to oxidative stress. (2006) (63)
- Specific amino acid sequences required for O6-methylguanine-DNA methyltransferase activity: analyses of three residues at or near the methyl acceptor site. (1992) (63)
- Transfer of the E. coli O6-methyltransferase gene into repair-deficient human cells and restoration of cellular resistance to N-methyl-N′-nitro-N-nitrosoguanidine (1986) (62)
- Release of N2,3-ethenoguanine from chloroacetaldehyde-treated DNA by Escherichia coli 3-methyladenine DNA glycosylase II. (1992) (60)
- The uvrD gene of E. coli encodes a DNA-dependent ATPase (1982) (60)
- Studies on the physiological defect in rII mutants of bacteriophage T4. (1966) (59)
- Structure and expression of the alkB gene of Escherichia coli related to the repair of alkylated DNA. (1986) (59)
- cDNA and genomic sequences for rat 8-oxo-dGTPase that prevents occurrence of spontaneous mutations due to oxidation of guanine nucleotides. (1995) (58)
- MutT‐related error avoidance mechanism for DNA synthesis (1996) (58)
- Identification of the uvrD gene product of Escherichia coli as DNA helicase II and its induction by DNA-damaging agents. (1984) (58)
- Proliferating Cell Nuclear Antigen Is Protected from Degradation by Forming a Complex with MutT Homolog2* (2009) (57)
- Effect of single DNA lesions on in vitro replication with DNA polymerase III holoenzyme. Comparison with other polymerases. (1994) (56)
- Characterization of human polymorphic DNA repair methyltransferase. (2000) (56)
- Stimulation of the UvrABC enzyme-catalyzed repair reactions by the UvrD protein (DNA helicase II). (1985) (53)
- Adaptive response: induced synthesis of DNA repair enzymes by alkylating agents (1987) (53)
- THE SYNTHESIS OF MESSENGER RNA WITHOUT PROTEIN SYNTHESIS. I. STUDIES WITH THYMINELESS STRAINS OF ESCHERICHIA COLI. (1964) (53)
- Structural and Dynamic Features of the MutT Protein in the Recognition of Nucleotides with the Mutagenic 8-Oxoguanine Base* (2009) (52)
- Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism. (1999) (50)
- Nucleases specific for ultraviolet light-irradiated DNA and their possible role in dark repair. (1968) (50)
- A strong mutator effect caused by an amino acid change in the alpha subunit of DNA polymerase III of Escherichia coli. (1991) (50)
- Potential of Escherichia coli GTP Cyclohydrolase II for Hydrolyzing 8-Oxo-dGTP, a Mutagenic Substrate for DNA Synthesis* (1998) (49)
- Biochemical and physicochemical characterization of normal and variant forms of human MTH1 protein with antimutagenic activity. (1997) (49)
- Roles of MGMT and MLH1 proteins in alkylation-induced apoptosis and mutagenesis. (2003) (49)
- Roles of transcription and repair in alkylation mutagenesis. (1994) (48)
- Transcriptional mutagenesis mediated by 8-oxoG induces translational errors in mammalian cells (2018) (48)
- Regulation of expression of the ada gene controlling the adaptive response. Interactions with the ada promoter of the Ada protein and RNA polymerase. (1989) (47)
- Functional sites of the Ada regulatory protein of Escherichia coli. Analysis by amino acid substitutions. (1988) (47)
- Roles of two types of O6-methylguanine-DNA methyltransferases in DNA repair. (1991) (47)
- A dominant (mutD5) and a recessive (dnaQ49) mutator of Escherichia coli. (1983) (45)
- Identification of the dnaQ gene product and location of the structural gene for RNase H of Escherichia coli by cloning of the genes. (1981) (45)
- A new conditional lethal mutator (dnaQ49) in Escherichia coli K12 (1978) (45)
- A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice. (2000) (45)
- Organization and expression of the human gene for O6-methylguanine-DNA methyltransferase. (1993) (44)
- Structure and expression of the dnaQ mutator and the RNase H genes of Escherichia coli: overlap of the promoter regions. (1983) (44)
- Expression and Prognostic Significance ofO6-Methylguanine-DNA Methyltransferase in Hepatocellular, Gastric, and Breast Cancers (2001) (44)
- Initial step of excision repair in Escherichia coli: replacement of defective function of uvr mutants by T4 endonuclease V. (1972) (43)
- Large-scale selection and analysis of temperature-sensitive mutants for cell reproduction from BHK cells (1982) (42)
- Loss of expression of DNA repair enzymes MGMT, hMLH1, and hMSH2 during tumor progression in gastric cancer (2003) (42)
- Killing and mutagenic actions of dacarbazine, a chemotherapeutic alkylating agent, on human and mouse cells: effects of Mgmt and Mlh1 mutations. (2004) (40)
- Sensitivity of Escherichia coli (MutT) and human (MTH1) 8-oxo-dGTPases to in vitro inhibition by the carcinogenic metals, nickel(II), copper(II), cobalt(II) and cadmium(II). (1997) (40)
- Specific binding of PCBP1 to heavily oxidized RNA to induce cell death (2018) (40)
- The DNA sequence encoding pldA gene, the structural gene for detergent-resistant phospholipase A of E. coli. (1984) (40)
- Oxidative Damage to RNA and Expression Patterns of MTH1 in the Hippocampi of Senescence-Accelerated SAMP8 Mice and Alzheimer’s Disease Patients (2011) (40)
- Positive and negative regulation of transcription by a cleavage product of Ada protein. (1990) (39)
- Expression of the ada gene of Escherichia coli in response to alkylating agents. Identification of transcriptional regulatory elements. (1988) (37)
- Functional Significance of the Conserved Residues for the 23-Residue Module among MTH1 and MutT Family Proteins* (1999) (37)
- Polymorphism in the human O6-methylguanine-DNA methyltransferase gene detected by PCR-SSCP analysis. (1996) (36)
- PCNA–MutSα-mediated binding of MutLα to replicative DNA with mismatched bases to induce apoptosis in human cells (2005) (36)
- Isolation and characterization of cDNA and genomic sequences for mouse O6-methylguanine-DNA methyltransferase. (1992) (36)
- Human proteins that specifically bind to 8-oxoguanine-containing RNA and their responses to oxidative stress. (2010) (36)
- Replication of plasmid pSC101 inEscherichia coli K12: Requirement fordnaA function (1977) (36)
- Intracellular localization and function of DNA repair methyltransferase in human cells. (1994) (35)
- Molecular cloning and characterization of the alkB gene of Escherichia coli (2004) (35)
- Synthesis of Deoxyribonucleic Acid by Phage-infected Escherichia coli in the Presence of Mitomycin C (1959) (35)
- Cloning and sequence of the gene encoding the major structural component of mannose-resistant fimbriae of Serratia marcescens (1988) (34)
- Oxidative damage of DNA, RNA and their metabolites in leukocytes, plasma and urine of Macaca mulatta: 8-oxoguanosine in urine is a useful marker for aging (2012) (34)
- Purification and structure of 3-methyladenine-DNA glycosylase I of Escherichia coli. (1986) (34)
- Further purification and characterization of T4 endonuclease V. (1976) (33)
- Regulation of expression of the cloned ada gene in Escherichia coli. (1985) (32)
- Modes of actions of two types of anti-neoplastic drugs, dacarbazine and ACNU, to induce apoptosis. (2007) (32)
- Importance of DNA repair in carcinogenesis: evidence from transgenic and gene targeting studies. (2001) (32)
- Effect ofmutY andmutM/fpg-1 mutations on starvation-associated mutation inEscherichia coli: implications for the role of 7,8-dihydro-8-oxoguanine (1996) (32)
- Mouse methyltransferase for repair of O6-methylguanine and O4-methylthymine in DNA. (1995) (31)
- Deficient Expression of O 6-Methylguanine-DNA Methyltransferase Combined With Mismatch-Repair Proteins hMLH 1 and hMSH 2 Is Related to Poor Prognosis in Human Biliary Tract Carcinoma (31)
- Effects of vanillin and o-vanillin on induction of DNA-repair networks: modulation of mutagenesis in Escherichia coli. (1990) (31)
- Artificial control of nuclear translocation of DNA repair methyltransferase. (1994) (30)
- Ability of various alkylating agents to induce adaptive and SOS responses: a study with lacZ fusion. (1985) (30)
- Release of N2,3-ethanoguanine from haloethylnitrosourea-treated DNA by Escherichia coli 3-methyladenine DNA glycosylase II. (1991) (30)
- Functional significance of conserved residues in the phosphohydrolase module of Escherichia coli MutT protein. (2000) (30)
- Isolation of a human X chromosome-linked gene essential for progression from G1 to S phase of the cell cycle. (1987) (28)
- A mutant of Micrococcus lyosodeikticus defective in a deoxyribonuclease activity specific for ultraviolet-irradiated DNA. (1967) (28)
- RNase H-defective mutants of Escherichia coli: A possible discriminatory role of RNase H in initiation of DNA replication (2004) (27)
- Role of Auf1 in elimination of oxidatively damaged messenger RNA in human cells. (2015) (27)
- Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein. (2011) (27)
- The Ada protein is a class I transcription factor of Escherichia coli (1993) (27)
- An infective deoxyribonucleic acid from bacteriophage phi-X174. (1960) (27)
- DNA-repair methyltransferase as a molecular device for preventing mutation and cancer (2005) (27)
- Age-related alterations in the expression of MTH2 in the hippocampus of the SAMP8 mouse with learning and memory deterioration (2009) (26)
- NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity. (2009) (26)
- Deficient expression ofO6-Methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma (2002) (25)
- THE SYNTHESIS OF MESSENGER RNA WITHOUT PROTEIN SYNTHESIS IN NORMAL AND PHAGE-INFECTED THYMINELESS STRAINS OF ESCHERICHIA COLI. (1963) (25)
- Nucleotide excision repair of oxidised genomic DNA is not a source of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine. (2016) (25)
- Combined loss of expression of O6‐methylguanine‐DNA methyltransferase and hMLH1 accelerates progression of hepatocellular carcinoma (2003) (25)
- Structure and function of dnaQ and mutD mutators of Escherichia coli. (1986) (25)
- Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA. (2012) (25)
- Molecular cloning and nucleotide sequence of the mutT mutator of Escherichia coli that causes A:T to C:G transversion (2004) (25)
- Gene silencing in phenomena related to DNA repair (2002) (25)
- Expression of the truncated E. coli O6-methylguanine methyltransferase gene in repair-deficient human cells and restoration of cellular resistance to alkylating agents. (1987) (25)
- Activation of Ada protein as a transcriptional regulator by direct alkylation with methylating agents. (1988) (25)
- Significance of the conserved amino acid sequence for human MTH1 protein with antimutator activity. (1997) (24)
- Enhanced O6-methylguanine-DNA methyltransferase activity in transgenic mice containing an integrated E. coli ada repair gene. (1989) (23)
- Function of high-mobility group A proteins in the DNA damage signaling for the induction of apoptosis (2016) (23)
- MGMT expression in murine bone marrow is a major determinant of animal survival after alkylating agent exposure. (2001) (23)
- Inhibition of Multiplication of Bacteriophage by Actinomycin (1961) (23)
- Studies on temperature-dependent ultraviolet light-sensitive mutants of bacteriophage T4: the structural gene for T4 endonuclease V. (1976) (22)
- Expression and prognostic significance of O6-methylguanine-DNA methyltransferase in hepatocellular, gastric, and breast cancers. (2001) (22)
- Polymorphisms and probable lack of mutation in a human mutT homolog, hMTH1, in hereditary nonpoliposis colorectal cancer. (1995) (22)
- Stabilization of cyclin E and cdk2 mRNAs at G1/S transition in Rat-1A cells emerging from the G0 state. (1995) (22)
- MutT-related proteins are novel progression and prognostic markers for colorectal cancer (2017) (21)
- Interaction of Ada protein with DNA examined by fluorescence anisotropy of the protein. (1990) (21)
- Molecular actions of Escherichia coli MutT for control of spontaneous mutagenesis. (2011) (21)
- Diverse substrate recognition and hydrolysis mechanisms of human NUDT5 (2011) (21)
- Effect of dna mutations on the replication of plasmid pSC101 in Escherichia coli K-12 (1979) (21)
- A deoxyribonuclease activity specific for ultraviolet-irradiated DNA: a chromatographic analysis. (1967) (21)
- Two ways of escaping from oxidative RNA damage: Selective degradation and cell death. (2019) (20)
- Methylation Dependent Functional Switch Mechanism Newly Found in the Escherichia coli Ada Protein (1994) (20)
- Elimination and Utilization of Oxidized Guanine Nucleotides in the Synthesis of RNA and Its Precursors* (2013) (20)
- The roles of human MTH1, MTH2 and MTH3 proteins in maintaining genome stability under oxidative stress. (2018) (19)
- Cloning and expression of the Bacillus subtilis methyltransferase gene in Escherichia coli ada- cells. (1989) (18)
- Characterization of O6-methylguanine-DNA methyltransferase in transgenic mice introduced with the E. coli ada gene. (1991) (17)
- Induction of a new enzyme activity to excise pyrimidine dimers in Escherichia coli infected with bacteriophage T4. (1972) (17)
- Organization and Expression of the Mouse MTH1 Gene for Preventing Transversion Mutation* (1997) (17)
- Characteristics of detergent-resistant phospholipase A overproduced in E. coli cells bearing its cloned structural gene. (1984) (17)
- Analysis of proteins associated with chromosome condensation in baby hamster kidney cells. (1984) (17)
- Folding topology and DNA binding of the N‐terminal fragment of ada protein (1993) (17)
- Repair of DNA damaged by methyl methanesulfonate in bacteriophage T4. (1976) (17)
- Proteolytic cleavage of Ada protein that carries methyltransferase and transcriptional regulator activities. (1988) (16)
- A specific inhibition of induction of adaptive response by o-vanillin, a potent comutagen. (1989) (16)
- Biochemical Studies on the χ Mutation of Bacteriophage T4: Differential Inhibition of χ+ and χ DNA Synthesis by Mitomycin C (1974) (16)
- Roles of DNA repair methyltransferase in mutagenesis and carcinogenesis (1997) (15)
- Organization and expression of the mouse gene for DNA repair methyltransferase. (1996) (15)
- Lowered Nudix type 5 (NUDT5) expression leads to cell cycle retardation in HeLa cells (2012) (15)
- Noninfectious bacteriophage produced by the action of mitomycin C. (1960) (15)
- A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA (2009) (15)
- The induction of chromosome condensation in tsBN2, a temperature-sensitive mutant of BHK21, inhibited by the calmodulin antagonist, W-7. (1985) (14)
- Transfer of the E. coli O6-methylguanine methyltransferase gene into repair-deficient human cells and restoration of cellular resistance to N-methyl-N'-nitro-N-nitrosoguanidine. (1986) (14)
- Different initial steps of apoptosis induced by two types of antineoplastic drugs. (2008) (13)
- An endonucleolytic activity specific for ultraviolet-irradiated DNA in wild type and mutant strains of Micrococcus lysodeikticus. (1967) (13)
- Are purine bases enzymatically inserted into depurinated DNA in Escherichia coli? (1982) (13)
- REPAIR OF DNA DAMAGED BY 4-NITROQUINOLINE 1-OXIDE: A COMPARISON OF ESCHERICHIA COLI AND BACTERIOPHAGE T4 REPAIR SYSTEMS (1976) (13)
- PCBP1 and PCBP2 both bind heavily oxidized RNA but cause opposing outcomes, suppressing or increasing apoptosis under oxidative conditions (2020) (13)
- Accumulation of Adenine DNA Glycosylase-sensitive Sites in Human Mitochondrial DNA* (2000) (12)
- Mutators and fidelity of DNA replication (1989) (12)
- 5' leads to 3'-Exonucleases of bacteriophage T4. (1976) (12)
- Role of uracil-DNA glycosylase in the repair of deaminated cytosine residues of DNA in Escherichia coli. (1978) (12)
- Structure of the activated c-raf-1 gene from human stomach cancer. (1986) (12)
- Molecular devices for high fidelity of DNA replication and gene expression (2006) (12)
- Action of exonuclease V (the recBC enzyme) on ultraviolet-irradiated DNA. (1975) (11)
- Phosphorylation of nonhistone proteins during premature chromosome condensation in a temperature-sensitive mutant, tsBN2. (1985) (11)
- Substrate specificity of human O6-methylguanine-DNA methyltransferase for O6-benzylguanine derivatives in oligodeoxynucleotides. (1997) (11)
- A unique structural feature of rabbit DNA repair methyltransferase as revealed by cDNA cloning. (1994) (10)
- SMARCAD1-mediated recruitment of the DNA mismatch repair protein MutLα to MutSα on damaged chromatin induces apoptosis in human cells (2019) (10)
- Transformation of temperature-sensitive growth mutant of BHK21 cell line to wild-type phenotype with hamster and mouse DNA (1983) (10)
- The Identification of a Novel Gene, MAPO2, That Is Involved in the Induction of Apoptosis Triggered by O6-Methylguanine (2012) (10)
- Molecular cloning of the uvrD gene of Escherichia coli that controls ultraviolet sensitivity and spontaneous mutation frequency (2004) (10)
- Cloning and expression of cDNA for rat O6-methylguanine-DNA methyltransferse (1991) (10)
- Intracellular distribution of the antimutagenic enzyme MTH1 in the liver, kidney and testis of F344 rats and its modulation by cadmium. (2001) (10)
- Isolation of conditional lethal mutator mutants of Escherichia coli by localized mutagenesis (1983) (10)
- Role of tryptophan residues in the recognition of mutagenic oxidized nucleotides by human antimutator MTH1 protein. (2002) (9)
- Crystallization and preliminary X-ray diffraction studies of 3-methyladenine-DNA glycosylase II from Escherichia coli. (1988) (9)
- Structure and function ofdnaQ andmutD mutators ofEscherichia coli (1986) (9)
- Conditional lethality of Escherichia coli strains carrying dnaE and dnaQ mutations. (1981) (9)
- ROS control in human iPS cells reveals early events in spontaneous carcinogenesis. (2019) (9)
- Induced Synthesis of O6‐Methylguanine‐DNA Methyltransferase in Rat Hepatoma Cells Exposed to DNA‐damaging Agents (1992) (8)
- Identification and cloning of the gene coding for lysophospholipase L2 of E. coli K-12. (1983) (8)
- Biochemical studies on radiation-sensitive mutations in bacteriophage T4-1. (1975) (8)
- Cloning and expresion of cDNA for rat O6-methylguanine-DNA methyltransferase. (1991) (8)
- Search for Proteins Required for Accurate Gene Expression under Oxidative Stress (2013) (8)
- Effect of metal ions on transcription of the ada gene which encodes O6-methylguanine-DNA methyltransferase of Escherichia coli. (1992) (8)
- Sequence-specific DNA recognition of the Escherichia coli Ada protein associated with the methylation-dependent functional switch for transcriptional regulation. (1995) (7)
- DNA Replication and Transcription (2006) (7)
- A New Locus of Escherichia coli That Determines Sensitivity to Bacteriophage φX174 (1979) (7)
- Knockout-associated Lung Tumorigenesis and Its Suppression by Mth 1 Gene Disruption 1 (2003) (7)
- Identification and nucleotide sequence of the gene determining the adhesion capacity of Serratia marcescens (1991) (7)
- Action of T4 endonuclease V on DNA containing various photoproducts. (1977) (7)
- Oxidative damage to nucleotide: Consequences and preventive mechanisms (2006) (7)
- Identification of a DNA segment containing the human dna polymerase α gene (1986) (7)
- Regulation of RecA protein binding to DNA by opposing effects of ATP and ADP on inter-domain contacts: analysis by urea-induced unfolding of wild-type and C-terminal truncated RecA. (2003) (6)
- Introduction of an active enzyme into permeable cells of Escherichia coli (1979) (6)
- Requirement of the Pro-Cys-His-Arg sequence for O6-methylguanine-DNA methyltransferase activity revealed by saturation mutagenesis with negative and positive screening (1994) (5)
- Infection of Actinomycin-Permeable Mutants of Escherichia coli with Urea-Disrupted Bacteriophage (1971) (5)
- Lowered Nudix type 5 expression leads to cellular senescence in IMR-90 fibroblast cells (2013) (5)
- Endonuclease Involved in Repair of DNA (5)
- Inhibitory effect of cadmium and mercury ions on transcription of the ada gene. (1991) (5)
- Purification and Characterization of Normal and Mutant Forms of T 4 Endonuclease V * (2001) (5)
- Alkylation carcinogenesis in mice with altered levels of DNA repair methyltransferase. (1999) (5)
- Excision of pyrimidine dimers in normal and T4-infected Escherichia coli: effect of polA and other mutations. (1975) (5)
- Repair of deaminated cytosine residues of DNA: biological significance of the absence of uracil from DNA. (1978) (5)
- Action of T4 endonuclease V on polydeoxyribonucleotides with apyrimidinic or apurinic sites. (1982) (5)
- Structural requirement for the induction of the adaptive response in Escherichia coli among N-(substituted alkyl)-N-nitrosoureas. (1988) (5)
- Presence of potential nickel-responsive element(s) in the mouse MTH1 promoter. (2001) (4)
- Stabilization of MAPO1 by specific binding with folliculin and AMP-activated protein kinase in O⁶-methylguanine-induced apoptosis. (2013) (4)
- 10 – Mitosis-Specific Protein Phosphorylation Associated with Premature Chromosome Condensation in a ts Cell Cycle Mutant (1987) (4)
- [Activated c-raf-1 gene from human stomach cancer]. (1987) (4)
- Crystallization and preliminary X-ray analysis of Escherichia coli MutT in binary and ternary complex forms. (2004) (3)
- PCBP1 and PCBP2 both bind heavily oxidized RNA but cause opposing outcomes, suppressing or increasing apoptosis under oxidative conditions. (2020) (3)
- Molecular mechanism of adaptive response to alkylating agents. (1986) (3)
- Metastatic phenotype in hybrid cells derived from B16 melanoma. (1994) (3)
- An enzyme activity specific for nitrous acid-treated DNA in Escherichia coli. (1978) (3)
- Replication intermediate of a hybrid plasmid carrying the replication terminus (ter) site of R6K as revealed by agarose gel electrophoresis (1987) (3)
- Regulatory elements for expression of the alkA gene in response to alkylating agents (1992) (3)
- Assay of repair enzyme activity by reactivation of ultraviolet-irradiated infective viral DNA. (1980) (3)
- Recovery of a hybrid vector, derived from bovine papilloma virus DNA, pBR322 and the HSV tk gene, by bacterial transformation with extrachromosomal DNA from transfected rodent cells. (1983) (3)
- Requirement for two conserved cysteine residues in the Ada protein ofEscherichia coli for transactivation of theada promoter (1996) (2)
- Acquisition of Resistance to Alkylating Agents by Expression of Methyltransferase Gene in Repair-Deficient Human Cells (1989) (2)
- REGlTLATION AND EXPRESSION OF THE i\DAPTIVE RESPONSE TO (1988) (2)
- Molecular mechanisms for controlling spontaneous and induced mutagenesis. (1991) (2)
- A quest to understand molecular mechanisms for genetic stability. (2006) (2)
- Enzymic mechanism of excision-repair in T4-infected cells. (1975) (2)
- DNA-mediated gene transfer to baby hamster kidney cells. (1982) (2)
- [Role of O6-methylguanine-DNA methyltransferase in repair of DNA damaged by alkylating agents]. (1989) (1)
- Identification of a DNA segment containing the human DNA polymerase alpha gene. (1986) (1)
- DNA repair. (2020) (1)
- Methylation Dependent Functional Switch Mechanism of the Escherichia coil Ada Protein (1995) (1)
- Cloning of mutator genes and identification of their products. (1982) (1)
- Molecular mechanisms of replicational fidelity in Escherichia coli. (1990) (1)
- A newly discovered tRNA1Asp gene (aspV) of Escherichia coli K12 (1987) (1)
- Greater nucleic acids oxidation in the temporal lobe than the frontal lobe in SAMP8 (2012) (1)
- The Expression of Bacteriophage T4 Early Genes (1978) (1)
- My path toward DNA repair. (2012) (1)
- Mammalian Enzymes for Preventing Mutations Caused by Oxidation of Guanine Nucleotides (1998) (1)
- Structure of the activated c-raf-1 gene from human stomach cancer. (1986) (1)
- Pathways for repair of DNA damaged by alkylating agent in Escherichia coli (1979) (1)
- Recombination of bacteriophage phi X174 by the red function of bacteriophage lambda (1979) (1)
- DEVOTED TO MOLECULAR AND CELLULAR MECHANISMS : GENES TO CELLS (1997) (1)
- 5’ + 3’-Exonucleases of Bacteriophage T4* (2002) (1)
- Conditionallethality of Escherichia coli strains carrying dnaE anddnaQ mutations (2004) (1)
- Structural basis of the substrate recognition and hydrolysis reaction mechanisms of 8-oxo-dGDPase (2008) (0)
- Deficient expression of O6-methylguanine-DNA methyltransferase correlates with the prognosis of hepatocellular carcinoma (2000) (0)
- Physiological function of the human MTH1, MTH2 and MTH3 proteins in genetic stability (2017) (0)
- Molecular mechanisms of repair of dna damaged by radiation (1981) (0)
- Molecular Cloning ofaHumanGeneThatRegulates Chromosome Condensation andIsEssential forCellProliferation (1986) (0)
- Assessment of Genomic Instability due to Mismatch Repair Deficiency : Analysis of Tumors developed in Msh2-deficient mice (2002) (0)
- Function of chromatin remodeler associated with the induction of mismatch repair-dependent apoptosis. (2016) (0)
- S III-2. Detection of human transforming genes using DNA-transfection (1985) (0)
- Requirement for two conserved cysteine residues in the Ada protein of (1996) (0)
- 191 Mutagenesis induced by X-irradiation in Mth1 knockout mice(Mutation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society) (2003) (0)
- I-3 DNA Repair (1984) (0)
- Possible target gene abnormality in 06-methyl-guanine-DNA methyltransferase (MGMT) deficient phenotype in gall bladder carcinoma (2000) (0)
- MECHANISM OF DNA REPAIR AND RECOMBINATION. (1972) (0)
- The identification of novel factors binding to oxidatively damaged RNA (2017) (0)
- The expression of bacteriophage T4 early genes. II. Roles of the beta' subunit of RNA polymerase and termination factor rho of the host in the expression of T4 early genes. (1978) (0)
- [Role of DNA replication and repair in mutagenesis]. (1972) (0)
- Proliferative Activation ofQuiescent Rat-lACells byAFosB (1993) (0)
- Physiological roles of human MTH1, MTH2 and MTH3 proteins in genome stability under oxidative stress (2016) (0)
- [A new repair pathway which involves direct excision of bases from DNA (author's transl)]. (1979) (0)
- Stimnlation of the UvrABC enzyme-catalyzed repair reactions by the UvrD protein (DNA heUcase II) (2005) (0)
- Structure and expression of the dnaQ mutator and the RNase H genes of Escherichia coli : Overlap of the promoter regions ( nucleotide sequence / down-promoter mutation / fused protein / mutD gene ) (1999) (0)
- A role of S.cerevisae Gtr1p on toxic substance exclusion (2016) (0)
- Lowered Nudix type 5 (NUDT5) expression leads to cell cycle retardation in HeLa cells (2011) (0)
- THE MGMT GENE-DISRUPTED MOUSE (1995) (0)
- Gene Expression under Oxidative Stress : Search for Proteins Required for Accurate DNA and Chromosomes : (2013) (0)
- Genetic systems for stability of DNA. (1997) (0)
- Correction: PCBP1 and PCBP2 both bind heavily oxidized RNA but cause opposing outcomes, suppressing or increasing apoptosis under oxidative conditions (2021) (0)
- Positive regulation of adaptive response by direct methylation of Ada protein (1988) (0)
- [Molecular biology of T 4 r II]. (1967) (0)
- The expression of bacteriophage T4 early genes. I. Four classes of patterns of expression in bacteriophage T4 early genes. (1978) (0)
- Visualization of mitochondrial membrane potential in Neuro-2a (1999) (0)
- Dynamics of epigenomic changes during development of embryos and germ cells in mice (2011) (0)
- [Repair of alkylated DNA and consequences of its failure]. (2001) (0)
- DIFFERENTIALSYNTHESISOF RIBONUCLEICACID IN PROSTATICNUCLEI:EVIDENCEFOR SELECTIVEGENE TRANSCRIPTIONINDUCED BY ANDROGENS* (1966) (0)
- Mechanisms of DNA Repair as Revealed by Artificial Introduction of Enzymes into Viable Cells (1983) (0)
- The crystal structures of Escherichia coli MutT proteins with and without manganese ions (2002) (0)
- Molecular biological aspects of the problems of human genetics (1977) (0)
- Erratum: Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes (Proceedings of the National Academy of Sciences of the United States of America (April 28, 1998) 95 (5116-5120)) (1998) (0)
- Radiation Biology in the Post-genome Era : (2001) (0)
- MTH1 Spontaneous tumorigenesis in mice defective in the (2006) (0)
- [The continuity of life and mutations]. (1993) (0)
- Gene Mutation and Carcinogenesis (1998) (0)
- Identification andNucleotide Sequence oftheGeneDetermining the Adhesion Capacity ofSerratia marcescens (1991) (0)
- Genetic Instability During Multistep Carcinogenesis in Mice with Targeted Disruption of MSH2 Gene (2001) (0)
- Restoration of defective cellular functions by supply of DNA polymerase I to permeable cells of Escherichia coli. (1981) (0)
- Identification of a new transfer rna gene in escherichia coli (1985) (0)
- Biochemical studies on the chi mutation of bacteriophage T4: differential inhibition of chi+ and chi DNA synthesis by mitomycin C. (1974) (0)
- Endogenous ROS production in early differentiation state suppresses endoderm differentiation via transient FOXC1 expression (2022) (0)
- Cloning andSequence oftheGeneEncoding theMajorStructural Component ofMannose-Resistant Fimbriae ofSerratia marcescens (1988) (0)
- GENES FOR CONTROL OF MUTA TION IN MA MMALIAN GELLS (1995) (0)
- 06-Methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis ( DNA repair / liver tumor / transgenic mouse / ada gene ) (2005) (0)
- Mutant E.Coli 3-methyladenine DNA glycosylase II reveals AP-lyase activity (2000) (0)
- The exploration of novel factors involving in elimination of oxidatively damaged mRNA (2016) (0)
- Role of chromatin remodeling factor in the induction of mismatch repair-dependent apoptosis (2017) (0)
- Two proteins, AUF1 and PCBP1, participate in elimination of oxidative RNA damage (2019) (0)
- Endogenous ROS production in early differentiation state suppresses endoderm differentiation via transient FOXC1 expression (2022) (0)
- Recombination of bacteriophage phiX174 by the red function of bacteriophage lambda. [Uv radiation] (1979) (0)
- MOLECULAR MECHANISMS OF REPLICATIONAL FIDELITY (1990) (0)
- Isolation ofTemperature-Sensitive MutantsofR Plasmid by InVitro Mutagenesis withHydroxylamine (1976) (0)
- Dynamics of tumor suppressor genes in iPS cells (2017) (0)
- Cloning and Characterization of the aZkA Gene of Escherichia coli That Encodes 3-Methyladenine DNA Glycosylase 11" (2001) (0)
- Stimulation of cell division by T4 infection in Escherichia coli dnaEts at nonpermissive temperature (1977) (0)
- Structure and function of the DNA repair enzyme 3-methyladenine DNA glycosylase II (1996) (0)
- [Mutation and oncogenesis]. (1985) (0)
- [Carcinogenesis and mutator genes]. (1984) (0)
- Mutant form of SDHC, mitochondrial complex II subunit in human iPS cells (2017) (0)
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