Mark T. Brookline Keating
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Mark T. Brookline Keatingengineering Degrees
Engineering
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Biomedical Engineering
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Electrical Engineering
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Engineering
Mark T. Brookline Keating's Degrees
- Masters Electrical Engineering Stanford University
Why Is Mark T. Brookline Keating Influential?
(Suggest an Edit or Addition)Mark T. Brookline Keating's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel (1995) (2373)
- A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome (1995) (2242)
- Genetic basis and molecular mechanism for idiopathic ventricular fibrillation (1998) (1747)
- Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias (1996) (1740)
- Heart Regeneration in Zebrafish (2002) (1700)
- Genotype-Phenotype Correlation in the Long-QT Syndrome: Gene-Specific Triggers for Life-Threatening Arrhythmias (2001) (1679)
- SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome (1995) (1658)
- Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel (1996) (1463)
- CaV1.2 Calcium Channel Dysfunction Causes a Multisystem Disorder Including Arrhythmia and Autism (2004) (1450)
- MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia (1999) (1349)
- Spectrum of Mutations in Long-QT Syndrome Genes: KVLQT1, HERG, SCN5A, KCNE1, and KCNE2 (2000) (1248)
- Hemizygosity at the elastin locus in a developmental disorder, Williams syndrome (1993) (1107)
- Molecular and Cellular Mechanisms of Cardiac Arrhythmias (2001) (968)
- Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. (1996) (834)
- Mutations in the hminK gene cause long QT syndrome and suppress lKs function (1997) (792)
- Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy. (1995) (780)
- Elastin is an essential determinant of arterial morphogenesis (1998) (766)
- Influence of the genotype on the clinical course of the long-QT syndrome. International Long-QT Syndrome Registry Research Group. (1998) (728)
- The spectrum of symptoms and QT intervals in carriers of the gene for the long-QT syndrome. (1992) (645)
- Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair (2007) (617)
- Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations. (2005) (593)
- p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. (2005) (573)
- Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene. (1991) (545)
- Actin mutations in dilated cardiomyopathy, a heritable form of heart failure. (1998) (542)
- LIM-kinase1 Hemizygosity Implicated in Impaired Visuospatial Constructive Cognition (1996) (530)
- Variant of SCN5A Sodium Channel Implicated in Risk of Cardiac Arrhythmia (2002) (527)
- Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia. (1996) (473)
- Dedifferentiation of Mammalian Myotubes Induced by msx1 (2000) (467)
- A critical role for elastin signaling in vascular morphogenesis and disease (2003) (465)
- Spectrum of ST-T–Wave Patterns and Repolarization Parameters in Congenital Long-QT Syndrome: ECG Findings Identify Genotypes (2000) (455)
- The elastin gene is disrupted by a translocation associated with supravalvular aortic stenosis (1993) (427)
- Fast inactivation causes rectification of the IKr channel (1996) (425)
- Tales of regeneration in zebrafish (2003) (401)
- Increased Risk of Arrhythmic Events in Long-QT Syndrome With Mutations in the Pore Region of the Human Ether-a-go-go–Related Gene Potassium Channel (2002) (386)
- Novel arterial pathology in mice and humans hemizygous for elastin. (1998) (366)
- FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction (2006) (347)
- Genomic organization of the human SCN5A gene encoding the cardiac sodium channel. (1996) (337)
- A cardiac arrhythmia syndrome caused by loss of ankyrin-B function (2004) (337)
- Molecular basis of the long-QT syndrome associated with deafness. (1997) (337)
- Multiple mechanisms of Na+ channel--linked long-QT syndrome. (1996) (336)
- Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia. (1995) (334)
- Roles for Fgf signaling during zebrafish fin regeneration. (2000) (331)
- Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides. (1996) (299)
- Genetically defined therapy of inherited long-QT syndrome. Correction of abnormal repolarization by potassium. (1996) (297)
- Spectrum and prevalence of cardiac sodium channel variants among black, white, Asian, and Hispanic individuals: implications for arrhythmogenic susceptibility and Brugada/long QT syndrome genetic testing. (2004) (295)
- Compound Mutations: A Common Cause of Severe Long-QT Syndrome (2004) (292)
- Strong correlation of elastin deletions, detected by FISH, with Williams syndrome: evaluation of 235 patients. (1995) (292)
- fgf20 Is Essential for Initiating Zebrafish Fin Regeneration (2005) (282)
- Metavinculin Mutations Alter Actin Interaction in Dilated Cardiomyopathy (2002) (277)
- Elastin point mutations cause an obstructive vascular disease, supravalvular aortic stenosis. (1997) (276)
- Gene Expression Analysis of Zebrafish Heart Regeneration (2006) (270)
- Impaired distal airway development in mice lacking elastin. (2000) (268)
- Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells. (1988) (267)
- Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneity (1994) (264)
- Deletions of the elastin gene at 7q11.23 occur in approximately 90% of patients with Williams syndrome. (1995) (242)
- Genomic structure of three long QT syndrome genes: KVLQT1, HERG, and KCNE1. (1998) (237)
- Long QT Syndrome-associated Mutations in the Per-Arnt-Sim (PAS) Domain of HERG Potassium Channels Accelerate Channel Deactivation* (1999) (224)
- Mammalian myotube dedifferentiation induced by newt regeneration extract (2001) (218)
- The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. (2006) (216)
- Supravalvular aortic stenosis associated with a deletion disrupting the elastin gene. (1994) (216)
- CACNA1H Mutations in Autism Spectrum Disorders* (2006) (214)
- Signal transduction by the platelet-derived growth factor receptor. (1988) (214)
- Mapping a cardiomyopathy locus to chromosome 3p22-p25. (1996) (207)
- A proliferation gradient between proximal and msxb-expressing distal blastema directs zebrafish fin regeneration. (2002) (204)
- Normal newt limb regeneration requires matrix metalloproteinase function. (2005) (201)
- Molecular Genetic Insights into Cardiovascular Disease (1996) (189)
- A human vascular disorder, supravalvular aortic stenosis, maps to chromosome 7. (1993) (186)
- Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration. (2002) (177)
- Age-gender influence on the rate-corrected QT interval and the QT-heart rate relation in families with genotypically characterized long QT syndrome. (1997) (176)
- The IPL gene on chromosome 11p15.5 is imprinted in humans and mice and is similar to TDAG51, implicated in Fas expression and apoptosis. (1997) (167)
- GTF2I hemizygosity implicated in mental retardation in Williams syndrome: Genotype–phenotype analysis of five families with deletions in the Williams syndrome region (2003) (166)
- Erratum: Long QT syndrome patients with mutations on the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate: Implications for gene-specific therapy (Circulation (1995) 92 (3381-3386)) (1996) (163)
- A novel human gene, WSTF, is deleted in Williams syndrome. (1998) (157)
- The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF. (2004) (155)
- Induction of lef1 during zebrafish fin regeneration (2000) (151)
- Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish (2006) (141)
- Anillin localization defect in cardiomyocyte binucleation. (2006) (140)
- Genetic approaches to cardiovascular disease. Supravalvular aortic stenosis, Williams syndrome, and long-QT syndrome. (1995) (134)
- Generation and characterization of Sca2 (ataxin-2) knockout mice. (2006) (133)
- Complete physical map of the common deletion region in Williams syndrome and identification and characterization of three novel genes (1998) (127)
- Activin-βA Signaling Is Required for Zebrafish Fin Regeneration (2007) (125)
- Consistent linkage of the long-QT syndrome to the Harvey ras-1 locus on chromosome 11. (1991) (121)
- Long QT Syndrome-associated Mutations in the S4-S5 Linker of KvLQT1 Potassium Channels Modify Gating and Interaction with minK Subunits* (1999) (113)
- Transcriptional Profiling of Caudal Fin Regeneration in Zebrafish (2006) (109)
- A new form of long QT syndrome associated with syndactyly. (1995) (106)
- ETL, a Novel Seven-transmembrane Receptor That Is Developmentally Regulated in the Heart (2001) (101)
- The common SCN5A mutation R1193Q causes LQTS-type electrophysiological alterations of the cardiac sodium channel (2004) (98)
- Functional Effects of Mutations in KvLQT1 that Cause Long QT Syndrome (1999) (94)
- Activin-betaA signaling is required for zebrafish fin regeneration. (2007) (90)
- A novel human gene FKBP6 is deleted in Williams syndrome. (1998) (86)
- Genotype-Phenotype Correlation in the Long-QT Syndrome (2001) (86)
- Processing of the platelet-derived growth factor receptor. Biosynthetic and degradation studies using anti-receptor antibodies. (1987) (84)
- Heat-shock protein 60 is required for blastema formation and maintenance during regeneration. (2005) (83)
- Long QT syndrome associated with syndactyly identified in females. (1995) (78)
- The long QT syndrome. A review of recent molecular genetic and physiologic discoveries. (1996) (78)
- Location of Mutation in the KCNQ1 and Phenotypic Presentation of Long QT Syndrome (2003) (77)
- Single HERG delayed rectifier K+ channels expressed in Xenopus oocytes. (1997) (77)
- Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1. (2004) (74)
- An intronic mutation causes long QT syndrome. (2004) (71)
- Relation between outer and luminal diameter in cannulated arteries. (1999) (68)
- Locus heterogeneity of autosomal dominant long QT syndrome. (1993) (66)
- Positional cloning of a temperature-sensitive mutant emmental reveals a role for sly1 during cell proliferation in zebrafish fin regeneration. (2003) (63)
- Assessment of polymorphism in zebrafish mapping strains. (1999) (59)
- Ligand activation causes a phosphorylation-dependent change in platelet-derived growth factor receptor conformation. (1988) (56)
- Long-QT Syndrome-Associated Missense Mutations in the Pore Helix of the HERG Potassium Channel (2001) (56)
- Platelet-derived growth factor receptors expressed by cDNA transfection couple to a diverse group of cellular responses associated with cell proliferation. (1988) (53)
- Role of delayed rectifier potassium channels in cardiac repolarization and arrhythmias (1997) (45)
- Pathophysiology of ion channel mutations. (1996) (40)
- Platelet Derived Growth Factor (PDGF) autocrine components in human tumor cell lines (1990) (32)
- Molecular cloning, characterization, and genomic localization of a human potassium channel gene. (1992) (32)
- Impaired interaction between the slide helix and the C-terminus of Kir2.1: a novel mechanism of Andersen syndrome. (2007) (31)
- Platelet-derived growth factor receptor inducibility is acquired immediately after translation and does not require glycosylation. (1989) (29)
- Tissue inhibitor of metalloproteinase 1 regulates matrix metalloproteinase activity during newt limb regeneration (2006) (28)
- CACNA 1 H Mutations in Autism Spectrum Disorders * (2006) (27)
- Genetic approaches to disease and regeneration. (2004) (22)
- On the trail of genetic culprits in Williams syndrome. (1997) (18)
- "The Force Be With You": ATP in Gut Mechanosensory Transduction (2003) (17)
- Generation and Characterization of LFG316, A Fully-Human Anti-C5 Antibody for the Treatment of Age-Related Macular Degeneration (2014) (17)
- Genomic localization of the human gene for KCNA10, a cGMP-activated K channel. (1997) (14)
- Defining the molecular genetic basis of idiopathic dilated cardiomyopathy. (1997) (12)
- George M. Cober Lecturer: Mark T. Keating. Molecular basis of the long-QT syndrome associated with deafness. (1997) (11)
- Evidence of Genetic Heterogeneity in the Long QT Syndrome (10)
- Risk of Cardiac Arrhythmia Variant of SCN 5 A Sodium Channel Implicated in (2007) (9)
- Isolation of P1 insert ends by direct sequencing. (1994) (8)
- Deletions of the Elastin Gene at 7q 1 1.23 Occur in -90O% of Patients with Williams Syndrome (2007) (8)
- Erratum: Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits (Journal of Biological Chemistry (1999) 274 (21063-21070)) (1999) (7)
- The stimulation of paracrine and autocrine mitogenic pathways by the platelet‐derived growth factor receptor (1987) (6)
- chapter 19 – Cardiac Arrhythmias: Inherited Molecular Mechanisms (2004) (6)
- Long QT genotype can be identified by ECG phenotype (1998) (5)
- Generation and characterization of CLG561: a fully-human, anti-properdin Fab for the treatment of age-related macular degeneration (2016) (5)
- Molecular characterization and refined genomic localization of three human potassium ion channel genes. (1995) (5)
- Relation between outer and luminal diameter in cannulated arteries. (1999) (4)
- Ligand activation causes a phosphorylation-dependent change in platelet-derived growth factor receptor conformation. (1988) (3)
- Long deletions of the Williams syndrome region on chromosome 7 result in more severe mental retardation (1999) (3)
- Phenotypic characterization of Timothy syndrome - a complex cardiac and multisystem disorder (2005) (3)
- The SRF Target Gene Fhl 2 Antagonizes RhoA / MAL-Dependent Activation of SRF Citation (2004) (3)
- Abstract 2439: Clinical Profile and Risk of Sudden Death in Children with Timothy Syndrome (2006) (2)
- Erratum: Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrythmia (Proceedings of the National Academy of Science of the United States of America (March 5, 1996) 93:5 (2208-2212)) (1996) (2)
- Dispersion of repolarization and the genotype of long QT syndrome (1996) (2)
- Platelet-derived growth factor receptor biosynthesis and degradation (1987) (2)
- Tesidolumab (LFG316) for treatment of C5-variant patients with paroxysmal nocturnal hemoglobinuria (2021) (2)
- Cardiac events in genotyped long QT syndrome patients (1998) (1)
- Potassium channels as targets for drug action (1993) (1)
- Clinical evaluation of a novel subcutaneous lactate monitor (2021) (1)
- Long QT syndrome patients genetically linked to defective genes on chromosomes 11, 7 and 3 present differential response to changes in heart rate (1996) (1)
- Molecular genetics of long QT syndrome. (1995) (0)
- Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration (2002) (0)
- Mending broken hearts: the future of drug-based cardiac regeneration. (2007) (0)
- The PDGF Receptor As A Mediator of Mitogenesis (1987) (0)
- Abstract 513: FGF1 Stimulation/ p38 Inhibition Induces Cardiomyocyte Mitosis, Reduces Scarring and Improves Function after Myocardial Infarction (2006) (0)
- Gene du syndrome du q-t long codant kvlqt1 et son association avec mink (1996) (0)
- Prevalence of the Bifid T Waves in Genotyped LQTS Children (1998) (0)
- Compositions a base d'elastine (2000) (0)
- Suppression of Retinal Inflammation in Endotoxin-Induced Uveitis by the Kinase Inhibitor, PKC412 (2007) (0)
- Mutations of the human mink gene, associated with arrhytmia (1998) (0)
- Mutations in the KCNE1 gene encoding human minK which cause arrhythmia susceptibility thereby establishing KCNE1 as an LQT gene (1999) (0)
- Compositions et procedes de dedifferenciation cellulaire et regeneration tissulaire (2001) (0)
- The platelet-derived growth factor system. (1989) (0)
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