Malcolm D. Lilly
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Malcolm D. Lillybiology Degrees
Biology
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#14973
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Molecular Biology
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#1819
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Biochemistry
#1923
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#2064
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Chemistry Biology
Malcolm D. Lilly's Degrees
- PhD Biochemistry Stanford University
- Bachelors Chemistry University of California, Berkeley
Why Is Malcolm D. Lilly Influential?
(Suggest an Edit or Addition)Malcolm D. Lilly's Published Works
Number of citations in a given year to any of this author's works
Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author
Published Works
- The isolation and kinetics of penicillin amidase from Escherichia coli. (1972) (281)
- In Situ Product Removal as a Tool for Bioprocessing (1993) (239)
- The properties of magnetic supports in relation to immobilized enzyme reactors (1973) (225)
- Porous glass as a solid support for immobilisation or affinity chromatography of enzymes. (1971) (197)
- The effect of agitation on the morphology and penicillin production of Penicillium chrysogenum (1990) (192)
- Some changes in the reactivity of enzymes resulting from their chemical attachment to water-insoluble derivatives of cellulose. (1968) (138)
- Release of enzymes from bakers' yeast by disruption in an industrial homogenizer (1971) (116)
- The kinetics of β‐galactosidase attached to porous cellulose sheets (1969) (110)
- The influence of mechanical forces on the morphology and penicillin production of Penicillium chrysogenum (1993) (105)
- Enzymic interesterification of fats: factors influencing the choice of support for immobilized lipase (1984) (104)
- The chemical attachment of chymotrypsin to water-insoluble polymers using 2-amino-4,6-dichloro-s-triazine. (1970) (104)
- Biotechnology: International Trends and Perspectives (1982) (90)
- Turbulent breakage of filamentous microorganisms in submerged culture in mechanically stirred bioreactors (1994) (89)
- The energetics of mammalian cell growth. (1969) (88)
- A comparative study of immobilized amyloglucosidase in a packed bed reactor and a continuous feed stirred tank reactor (1971) (88)
- The preparation and kinetics of lactate dehydrogenase attached to water-insoluble particles and sheets. (1968) (86)
- Effect of processing parameters on the feasibility and operational stability of immobilized viable microbial cells (1998) (82)
- Conversion of benzylpenicillin to 6‐aminopenicillanic acid in a batch reactor and continuous feed stirred tank reactor using immobilized penicillin amidase (1973) (81)
- Enzyme-catalysed carbon–carbon bond formation: use of transketolase from Escherichia coli (1993) (76)
- Cofactor recycling in an enzyme reactor. A comparison Using free and immobilized dehydrogenases with free and immobilized NAD (1975) (76)
- Release of protein from Bakers' yeast (Saccharomyces cerevisiae) by disruption in an industrial agitator mill (1972) (75)
- The conversion of benzyl penicillin to 6‐aminopenieillanie acid using an insoluble derivative of penieillin amidase (1969) (75)
- Immobilisation of -amylase by attachment to soluble support materials. (1971) (75)
- The preparation of soluble high molecular weight NAD derivative active as a cofactor. (1972) (71)
- Letter: Purification of enzymes using magnetic bio-affinity materials. (1974) (71)
- Estimation of cell volume and biomass of penicillium chrysogenum using image analysis (1992) (70)
- Enzymic interesterification of fats: Laboratory and pilot‐scale studies with immobilized lipase from Rhizopus arrhizus (1987) (69)
- The Interactions Between Fermentation and Protein Recovery (1984) (68)
- Characteristics of mechanically disrupted bakers' yeast in relation to its separation in industrial centrifuges (1981) (66)
- Transketolase from Escherichia coli: A practical procedure for using the biocatalyst for asymmetric carbon-carbon bond synthesis (1996) (64)
- Preparation and use of insolubilized amyloglucosidase for the production of sweet glucose liquors (1969) (63)
- Effect of cycling dissolved oxygen concentrations on product formation in penicillin fermentations (1982) (63)
- The kinetics of protein salting‐Out: Precipitation of yeast enzymes by ammonium sulfate (1976) (62)
- Eighth P. V. Danckwerts memorial lecture presented at Glaziers' Hall, London, U.K. 13 May 1993: Advances in biotransformation processes (1994) (61)
- Power drawn by multiple impellers in sparged agitated vessels (1979) (60)
- The effect of dissolved oxygen partial pressure on the growth and carbohydrate metabolism of mouse LS cells. (1969) (60)
- Nonporous magnetic materials as enzyme supports: Studies with immobilized chymotrypsin (1977) (59)
- Catabolite repression and the induction of amidase synthesis by Pseudomonas aeruginosa 8602 in continuous culture. (1968) (58)
- An ultrafiltration‐reactor system using a soluble immobilized enzyme (1971) (58)
- The characterization and interconversion of three forms of cholesterol oxidase extracted from Nocardia rhodochrous. (1982) (58)
- Preparation and Use of Porous Sheets with Enzyme Action (1968) (56)
- The influence of vessel height and top‐section size on the hydrodynamic characteristics of airlift fermentors (1994) (56)
- Immobilized enzyme reaction stability: Attrition of the support material (1974) (53)
- The precipitation of enzymes from cell extracts of Saccharomyces cerevisiae by polyethyleneglycol. (1973) (51)
- Escherichia coli transketolase-catalyzed carbon-carbon bond formation: biotransformation characterization for reactor evaluation and selection (1998) (51)
- Investigation of the unit operations involved in the continuous flow isolation of β‐galactosidase from Escherichia coli (1978) (51)
- Two-liquid phase biocatalysis: epoxidation of 1,7-octadiene by Pseudomonas putida (1986) (51)
- Use of immobilized cells of Rhizopus nigricans for the 11α‐hydroxylation of progesterone (1981) (48)
- Multiple steady states in continuous flow stirred tank enzyme reactors (1971) (47)
- Enzyme-catalysed carbon-carbon bond formation: large-scale production of Escherichia coli transketolase. (1996) (47)
- Stability of a Catabolic Plasmid in Continuous Culture (1985) (46)
- The kinetics of cholesterol oxidase synthesis by Nocardia rhodocrous (1976) (44)
- Production of naphthalene-cis-glycol by Pseudomonas putida in the presence of organic solvents (1992) (44)
- Alkaline biocatalysis for the direct synthesis of N-acetyl-D-neuraminic acid (Neu5Ac) from N-acetyl-D-glucosamine (GlcNAc). (1999) (44)
- Characterization of the Chemoenzymatic Synthesis of N‐Acetyl‐d‐neuraminic Acid (Neu5Ac) (1996) (44)
- THE RELATIONSHIPS BETWEEN BIOMASS CONCENTRATION, DETERMINED BY A CAPACITANCE-BASED PROBE, RHEOLOGY AND MORPHOLOGY OF SACCHAROPOLYSPORA ERYTHRAEA CULTURES (1996) (42)
- Lewis cell studies to determine reactor design data for two‐liquid‐phase bacterial and enzymic reactions (1991) (42)
- The utilization of mixed sugars in continuous fermentation. I. (1967) (41)
- The preparation and properties of pyruvate kinase attached to porous sheets, and the operation of a two-enzyme continuous-feed reactor. (1968) (40)
- Enzymic interesterification of fats: The effect of non-lipase material on immobilized enzyme activity (1985) (40)
- The enzymatic transformation of water‐insoluble reactants in nonaqueous solvents. Conversion of cholesterol to cholest‐4‐ene‐3‐one by a Nocardia sp. (2000) (38)
- The preparation and kinetics of immobilised penicillin amidase from Escherichia coli. (1972) (37)
- Gas holdup and liquid circulation rate in concentric-tube airlift bioreactors (1994) (37)
- Deacylation of benzylpenicillin by immobilized penicillin acylase in a continuous four‐stage stirred‐tank reactor (1979) (36)
- A structured approach to design and operation of biotransformation processes (1996) (36)
- Extractive biocatalysis: the use of two-liquid phase biocatalytic reactors to assist product recovery (1990) (35)
- Two-liquid phase biocatalytic reactors (1983) (34)
- Effect of Ferricyanide on Energy Production by Escherichia coli (1966) (32)
- Optimization of the production of progesterone 11α‐hydroxylase by Rhizopus nigricans (1980) (32)
- Biotransformation reactor selection and operation (1994) (31)
- Immobilised transketolase for carbon-carbon bond synthesis: biocatalyst stability (1999) (31)
- Stability of the steroid Δ1-dehydrogenation system of Arthrobacter simplex in organic solvent-water two-liquid phase environments (1988) (31)
- Toluene cis-glycol synthesis by Pseudomonas putida; kinetic data for reactor evaluation (1990) (30)
- Factors affecting scale-up of affinity chromatography of -galactosidase. (1972) (30)
- Process design for the oxidation of fluorobenzene to fluorocatechol by Pseudomonas putida (1997) (30)
- Salting-out of enzymes with ammonium sulphate. (1971) (29)
- Effect of solvent concentration on enzyme catalysed interesterification of fats (1988) (29)
- Stereospecific hydrolysis of d,l-menthyl acetate by Bacillus subtilis: mass transfer-reaction interactions in a liquid-liquid system (1986) (29)
- Process Engineering of Two-Liquid Phase Biocatalysis (1992) (29)
- Influence of dissolved oxygen tension on the synthesis of catechol 1,2-dioxygenase by Pseudomonas putida (1992) (28)
- Biotransformations in organic solvents: A difference between Gram-positive and Gram-negative bacteria (1989) (28)
- The use of free and immobilised Arthrobacter simplex in organic solvent/aqueous two-liquid-phase reactors (1990) (27)
- The clarification of mechanically disrupted yeast suspensions by rotary vacuum precoat riltration (1973) (27)
- Use of immobilized Bacillus subtilis for the stereospecific hydrolysis of d,l-menthyl acetate (1987) (26)
- Regulation of Amidase Synthesis by Pseudomonas aeruginosa 8602 in Continuous Culture (1967) (26)
- The use of Free and Immobilized Cells in the Presence of Organic Solvents: The Oxidation of Cholesterol by Nocardia Rhodochrous (1980) (25)
- The influence of dissolved oxygen partial pressure on the level of various enzymes in mouse LS cells (1968) (24)
- Effect of supersaturated aqueous hydrocortisone concentrations on the Δ1-dehydrogenase activity of free and immobilized Arthrobacter simplex (1984) (24)
- Extraction of cholesterol oxidase from Nocardia rhodochrous (1980) (23)
- A General Structure for Cell Walls of Gram-Negative Bacteria (1962) (23)
- Development of a large‐scale continuous substrate feed process for the biotransformation of simvastatin by Nocardia s.p. (1991) (22)
- Two‐liquid‐phase biocatalytic reactions (2007) (22)
- The theoretical aspects of biochemical fuel cells (1966) (22)
- Conversion of tyrosine to L-dihydroxyphenylalanine using immobilized tyrosinase. (1971) (22)
- Pilot scale affinity chromatography: Purification of β‐galactosidase (1974) (22)
- Carbon‐Carbon Bond Synthesis (1996) (21)
- Enzymic acylation of 6-aminopenicillanic acid (1982) (20)
- Oxygen transfer measurements during yeast fermentations in a pilot scale airlift fermenter (1995) (19)
- Production of cell tissue from hydrocarbons by a microbiological process (1965) (19)
- Casein hydrolysis in stirred tank reactors using chymotrypsin immobilized on magnetic supports (1981) (19)
- The influence of dissolved oxygen tension on the synthesis of the antibiotic difficidin by bacillus subtilis. (1994) (18)
- The measurement of oxygen-transfer coefficients in fermentors by frequency response techniques. (1982) (18)
- Stirred Tank Two-Liquid Phase Biocatalytic Reactor Studies: Kinetics, Evaluation and Modelling of Substrate Mass Transfer (1991) (17)
- The effect of controlled feeding of glycerol on β‐galactosidase production by Escherichia coli in batch culture (1973) (17)
- Turbulent breakage of filamentous bacteria in mechanically agitated batch culture (2000) (17)
- A method for the control of the dissolved oxygen tension in microbial cultures (1967) (17)
- A comparison of pig liver esterase and Bacillus subtilis as catalysts for the hydrolysis of menthyl acetate in stirred two-liquid phase reactors (1990) (16)
- Maintenance and operational stability of immobilized Arthrobacter simplex for the ▵1-dehydrogenation of steroids (1985) (16)
- Saccharomyces cerevisiae fermentations in a pilot scale airlift bioreactor: Comparison of air sparger configurations (1996) (15)
- Production of Intracellular Microbial Enzymes (1979) (15)
- The δ'-dehydrogenation of hydrocortisone by Arthrobacter simplex in organic-aqueous two-liquid phase environments (1987) (15)
- The Impact of Biocatalyst Selection on the Design of Aqueous‐Organic Biphasic Biocatalytic Processes a (1990) (14)
- [13] Two-liquid phase biocatalytic reactors (1987) (14)
- The immobilization of glucose oxidase to manganese oxide. (1976) (14)
- THE ACCUMULATION OF NUCLEOTIDES BY ESCHERICHIA COLI STRAIN 26-26. (1963) (14)
- Influence of a propeller on Saccharomyces cerevisiae fermentations in a pilot scale airlift bioreactor (1997) (12)
- The production of Pseudomonas putida for the hydroxylation of toluene to its cis-glycol (1994) (12)
- Transketolase from Escherichia coli: A Practical Procedure for Using the Biocatalyst for Asymmetric Carbon-Carbon Bond Synthesis. (1997) (12)
- Production of yeast‐lytic enzymes by Cytophaga species in batch culture (1981) (12)
- Large‐Scale isolation of acid phosphatase from human erythrocytes (1968) (11)
- Affinity chromatography of enzyme cofactors: the separation of NAD on immobilised dehydrogenase colums. (1975) (11)
- An HPLC procedure for monitoring penicillin G fermentations (1991) (11)
- Fermentation: An Overview (2001) (11)
- A high-performance liquid chromatography method for the simultaneous assay of diaminopimelate epimerase and decarboxylase. (1989) (11)
- Oxidation of n-alkanes: Growth of Pseudomonas putida (1982) (10)
- Enzymic Interesterification of fats: Immobilization and Immunogold Localization of Lipase on Ion-Exchange Resins (1990) (10)
- The synthesis of beta-galactosidase by constitutive and other regulatory mutants of Escherichia coli in chemostat culture. (1975) (10)
- The bioengineering of immobilized enzymes. (1973) (9)
- Deacylation of benzylpenicillin by immobilized penicillin acylase. (1980) (9)
- Process design implications of aldehyde properties on transketolase-catalysed condensations (1999) (9)
- Modifications to the Mackereth oxygen electrode (1967) (9)
- An airlift loop reactor for the transformation of steroids by immobilized cells (2005) (9)
- The effect of water-miscible solvents on the Δ1-dehydrogenase activity of free and PAAH-entrapped Arthrobacter simplex (1987) (9)
- Magnetic particles as supports in immobilised enzyme reactors (1975) (9)
- The effect of culture conditions on the production of erythromycin by Saccharopolyspora erythraea in batch culture (1996) (9)
- Immobilised enzymes (1979) (8)
- Carbon‐Carbon Bond Synthesis (1996) (8)
- Enzyme-Catalyzed Carbon-Carbon Bond Formation: Use of Transketolase from Escherichia coli. (1993) (8)
- The development of biochemical engineering science in Europe (1997) (8)
- The influence of the physical environment in fermenters on antibiotic production by microorganisms (1992) (7)
- The Design and Operation of Biotransformation Processes (1992) (7)
- Production of cyclohexanone monooxygenase from Acinetobacter calcoaceticus for large scale Baeyer–Villiger monooxygenase reactions (2001) (7)
- Topics in enzyme and fermentation technology, 10 (1986) (7)
- Continuous enzyme processing: The isolation of prolyl‐tRNA synthetase from Phaseolus Aureus (1970) (6)
- Pilot‐plant production of prednisolone using calcium alginate immobilized Arthrobacter simplex (1986) (6)
- The Examination of Bioreactor Heterogeneity with Rheological Different Fermentation Broths (1994) (5)
- Chapter 8 – A Comparison of Cells and Enzymes as Industrial Catalysts (1977) (5)
- Large‐scale isolation of prolyl‐tRNA synthetase from Phaseolus aureus (1967) (5)
- Oxidation of n-alkanes: Isolation of alkane hydroxylase from Pseudomonas putida (2004) (5)
- The isolation of an aliphatic amidase from Pseudomonas aeruginosa (1969) (5)
- Immobilization of Penicillium chrysogenum: spore growth on Celite (1989) (5)
- Large scale isolation of choline acetyltransferase from ox brains (1973) (5)
- Rheological measurements of three Actinomycete in submerged cultures (1995) (4)
- Denaturation and inhibition studies in a two-liquid phase biocatalytic reaction: the hydrolysis of menthyl acetate by pig liver esterase (1987) (4)
- Select and design (1996) (4)
- The enzymatic transformation of water‐insoluble reactants in nonaqueous solvents. Conversion of cholesterol to cholest‐4‐ene‐3‐one by a Ncardia sp. (1975) (4)
- Use of comparative reasoning tools for evaluation of the effect of sterilization conditions on fermentations to produce acidic fibroblast growth factor (1995) (4)
- Effect of ferricyanide on Escherichia coli. (1970) (4)
- The effect of cycling dissolved oxygen tension on the synthesis of the antibiotic difficidin by bacillus subtilis (1995) (4)
- Operational Modes of Bioreactors: BIOTOL Series, Butterworth—Heinemann, 1992. UK£19.95 (x + 282 pages) ISBN 0 7506 1508 7 (1993) (3)
- The Design and Implementation of a Comparative Reasoning Tool for Fermentations (1992) (3)
- The kinetics of beta-galactosidase attached to porous cellulose sheets. (1969) (3)
- TWO-LIQUID-PHASE BIOCATALYTIC REACTIONS (1982) (3)
- Effect of ferricyanide onEscherichia coli (2005) (3)
- Regiospecific naphthalene monohydroxylation by a recombinant yeast producing a P4501A1–yeast reductase fused enzyme (2003) (3)
- Problems in Scale-up of Immobilized Cell Cultures (1996) (3)
- Evaluation of process options for the biotransformation of toluene to toluene -glycol by (1991) (2)
- Communication to the Editor The Influence of Dissolved Oxygen Tension on the Synthesis of the Antibiotic Difficidin by Bacillus su btilis (1994) (1)
- A process for the preparation of 6-aminopenicillanic acid. (1971) (1)
- Guidelines for the characterization of immobilized cells. (1996) (1)
- The kinetics of a novel cyclic reaction system and its use in the assay of polynucleotide phosphorylase or adenosine diphosphate plus adenosine triphosphate. (1968) (1)
- Alkaline Biocatalysis for the Direct Synthesis of N‐Acetyl‐D‐neuraminic Acid (Neu5Ac) from N‐Acetyl‐D‐glucosamine (GlcNAc) (2000) (1)
- Saccharomyces cerevisiae fermentations in a pilot scale airlift bioreactor: Comparison of air sparger configurations (1996) (1)
- Microbial Halogenation With Specific Reference to Chiloroperoxidase (2017) (0)
- The effect of cycling dissolved oxygen tension on the synthesis of the antibiotic difficidin by (1995) (0)
- Enzymes attached (1974) (0)
- Introduction to Two-Liquid-Phase Systems II (1992) (0)
- Pilot scale affinity chromatography: purification of beta-galactosidase. (1974) (0)
- The effect of high speed blending upon Penicillium chrysogenum (1994) (0)
- Biochemical Engineering For Flavour and Food Production (1989) (0)
- Influence of a propeller on (1997) (0)
- Industrial and diagnostic enzymes : proceedings of a Royal Society discussion meeting held on 16 and 17 June 1982 (1983) (0)
- Mass Transfer Problems with Immobilized Oxidases (1978) (0)
- Recent Developments in Enzyme Isolation Processes (1974) (0)
- Stabilisation of industrial enzymes (2007) (0)
- Well-Mixed Immobilized Enzyme Reactors (1974) (0)
- The problems of large scale extraction and purification of microbial enzymes. (1971) (0)
- On time but out of rhyme (1983) (0)
- PROCESS DESIGN IMPLICATIONS OF ALDEHYDE PROPERTIES ON CONDENSATIONS TRANSKETOLASE-CATALYSED (1999) (0)
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