Malcolm Steinberg

Malcolm Steinberg's AcademicInfluence.com Rankings

Malcolm Steinberg

Biology

#2965

World Rank

#4609

Historical Rank

Cell Biology

#324

World Rank

#332

Historical Rank

Molecular Biology

#609

World Rank

#624

Historical Rank

Genetics

#863

World Rank

#957

Historical Rank

biology Degrees

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Biology

Malcolm Steinberg's Degrees

Masters Biotechnology Stanford University

Why Is Malcolm Steinberg Influential?

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According to Wikipedia, Malcolm Saul Steinberg was an American biologist who proposed the differential adhesion hypothesis as a mechanism explaining cell sorting during embryogenesis and cancer. Steinberg proposed that when cells form distinct tissues, specific cell-cell adhesion between cells from the same tissue can drive the separation. He further proposed that a difference in level of cell adhesion molecules expression between two cell types was sufficient to drive the separation. He confirmed these predictions in a model system in which adhesion between cells of a cultured line of mouse cells was controlled by genetic expression levels of cadherin.

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Malcolm Steinberg's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Reconstruction of Tissues by Dissociated Cells (1963) (988)
The differential adhesion hypothesis: a direct evaluation. (2005) (776)
Does differential adhesion govern self-assembly processes in histogenesis? Equilibrium configurations and the emergence of a hierarchy among populations of embryonic cells. (1970) (635)
Experimental specification of cell sorting, tissue spreading, and specific spatial patterning by quantitative differences in cadherin expression. (1994) (583)
Surface tensions of embryonic tissues predict their mutual envelopment behavior. (1996) (450)
Viscoelastic properties of living embryonic tissues: a quantitative study. (1998) (446)
Cadherin-mediated cell adhesion and tissue segregation: qualitative and quantitative determinants. (2003) (352)
Differential adhesion in morphogenesis: a modern view. (2007) (341)
Coaction of intercellular adhesion and cortical tension specifies tissue surface tension (2010) (315)
Cadherins and their connections: adhesion junctions have broader functions. (1999) (307)
Tissue spreading on implantable substrates is a competitive outcome of cell–cell vs. cell–substratum adhesivity (2001) (238)
The Problem of Adhesive Selectivity in Cellular Interactions (1964) (233)
Reconstruction of tissues by dissociated cells. Some morphogenetic tissue movements and the sorting out of embryonic cells may have a common explanation. (1963) (227)
On the mechanism of tissue reconstruction by dissociated cells. I. Population kinetics, differential adhesiveness. and the absence of directed migration. (1962) (226)
ON THE MECHANISM OF TISSUE RECONSTRUCTION BY DISSOCIATED CELLS, III. FREE ENERGY RELATIONS AND THE REORGANIZATION OF FUSED, HETERONOMIC TISSUE FRAGMENTS. (1962) (217)
Cadherin-mediated cell-cell adhesion and tissue segregation in relation to malignancy. (2004) (204)
Human autoantibodies against a desmosomal core protein in pemphigus foliaceus (1984) (195)
Isolation of the intercellular glycoproteins of desmosomes (1981) (195)
Mechanism of Tissue Reconstruction by Dissociated Cells, II: Time-Course of Events (1962) (185)
Adhesion in development: an historical overview. (1996) (161)
The role of cell‐cell contact in “contact” inhibition of cell division: A review and new evidence (1972) (150)
A monoclonal antibody to the desmosomal glycoprotein desmoglein I binds the same polypeptide as human autoantibodies in pemphigus foliaceus. (1986) (147)
Quantitative differences in tissue surface tension influence zebrafish germ layer positioning (2008) (138)
On the Chemical Bonds between Animal Cells. A Mechanism for Type-Specific Association (1958) (128)
A rheological mechanism sufficient to explain the kinetics of cell sorting. (1972) (121)
Immunochemical characterization of related families of glycoproteins in desmosomes. (1983) (106)
"ECM": its nature, origin and function in cell aggregation. (1963) (100)
Adhesion-guided multicellular assembly: a commentary upon the postulates, real and imagined, of the differential adhesion hypothesis, with special attention to computer simulations of cell sorting. (1975) (90)
Contact inhibition of what? An analytical review (1973) (90)
Embryonic tissues as elasticoviscous liquids. I. Rapid and slow shape changes in centrifuged cell aggregates. (1978) (87)
Two distinct adhesion mechanisms in embryonic neural retina cells. I. A kinetic analysis. (1981) (85)
Germ-layer surface tensions and "tissue affinities" in Rana pipiens gastrulae: quantitative measurements. (1997) (85)
On the molecular organization, diversity and functions of desmosomal proteins. (1987) (84)
DO MORPHOGENETIC TISSUE REARRANGEMENTS REQUIRE ACTIVE CELL MOVEMENTS? (1972) (70)
Equilibrium measurements of embryonic chick cell adhesiveness. I. Shape equilibrium in centrifugal fields. (1969) (69)
Immunological comparison of desmosomal components from several bovine tissues (1984) (68)
Experimental modulation of intercellular cohesiveness: reversal of tissue assembly patterns. (1972) (67)
Measurement of tumor cell cohesion and suppression of invasion by E- or P-cadherin. (1997) (65)
Two distinct adhesion mechanisms in embryonic neural retina cells. II. An immunological analysis. (1981) (64)
Evidence for the guidance of pronephric duct migration by a craniocaudally traveling adhesion gradient. (1982) (64)
Contact inhibitions of overlapping and differential cell adhesion: a sufficient model for the control of certain cell culture morphologies. (1974) (62)
Embryonic tissues as elasticoviscous liquids. II. Direct evidence for cell slippage in centrifuged aggregates. (1977) (62)
Amphibian pronephric duct morphogenesis: segregation, cell rearrangement and directed migration of the Ambystoma duct rudiment. (2020) (62)
Specific Cell Ligands and the Differential Adhesion Hypothesis: How do they fit together? (1978) (54)
The role of temperature in the control of aggregation of dissociated embryonic cells. (1962) (54)
Two distinct adhesion mechanisms in embryonic neural retina cells. III. Functional specificity. (1981) (54)
Differential adhesion in model systems (2013) (52)
Isolation of the non-glycosylated proteins of desmosomes and immunolocalization of a third plaque protein: desmoplakin III. (1985) (50)
Townes and Holtfreter (1955): directed movements and selective adhesion of embryonic amphibian cells. (2004) (49)
Intercellular adhesions as determinants of tissue assembly and malignant invasion (1997) (48)
Strategies for specifying form and pattern: adhesion-guided multicellular assembly. (1981) (45)
Liquid behavior of embryonic tissues (1982) (45)
Goal‐directedness in embryonic development (1998) (44)
Cranial neural crest cells exhibit directed migration on the pronephric duct pathway: further evidence for an in vivo adhesion gradient. (1986) (41)
A molecular marker for cell guidance information in the axolotl embryo. (1988) (40)
Cell-cell recognition in multicellular assembly: levels of specificity. (1978) (40)
Tissue-specific Sorting-out in Two Dimensions in Relation to Contact Inhibition of Cell Movement (1973) (35)
Observations on the sorting-out of embryonic cells in monolayer culture. (1975) (35)
Cell locomotion within a contact-inhibited monolayer of chick embryonic liver parenchyma cells. (1975) (35)
Do rates of intercellular adhesion measure the cell affinities reflected in cell-sorting and tissue-spreading configurations? (1976) (31)
Studies on the mechanism of physiological dominance in Tubularia (1954) (29)
Axolotl pronephric duct cell migration is sensitive to phosphatidylinositol-specific phospholipase C. (1989) (27)
Dexamethasone up-regulates cadherin expression and cohesion of HT-1080 human fibrosarcoma cells. (1998) (25)
Embryonic cell adhesiveness: do species differences exist among warm-blooded vertebrates? (1969) (23)
The movement of single cells within solid tissue masses. (1973) (23)
CELL MOVEMENT, RATE OF REGENERATION, AND THE AXIAL GRADIENT IN TUBULARIA (1955) (22)
Movement in a confluent 3T3 monolayer and the causes of contact inhibition of overlapping. (1974) (22)
Cell movement in confluent monolayers: a re-evaluation of the causes of 'contact inhibition'. (1973) (22)
Chemotaxis or adhesion gradient? Pronephric duct elongation does not depend on distant sources of guidance information. (1987) (21)
Experimental evidence for a proteinaceous presegmental wave required for morphogenesis of axolotl mesoderm. (1985) (20)
Two chick embryonic adhesion systems: molecular vs tissue specificity. (1981) (19)
PHASES IN CELL AGGREGATION AND TISSUE RECONSTRUCTION AN APPROACH TO THE KINETICS OF CELL AGGREGATION. (1964) (19)
Desmosomal antigens are not recognized by the majority of pemphigus autoimmune sera. (1983) (18)
Morphogenesis of the axolotl pronephric duct: a model system for the study of cell migration in vivo. (1996) (17)
Three populations of migrating amphibian embryonic cells utilize different guidance cues. (1993) (17)
Cell movements in a confluent monolayer are not caused by gaps: evidence for direct contact inhibition of overlapping. (1978) (15)
The Cell Surface in Development and Cancer (1986) (15)
A twelve-channel automatic device for continuous recording of cell aggregation by measurement of small-angle light-scattering. (1980) (15)
Ultrastructural and biochemical identification of con A receptors in the desmosome (1982) (14)
On the recovery of adhesiveness by trypsin-dissociated cells (2005) (12)
Elongation of axolotl tailbud embryos requires GPI-linked proteins and organizer-induced, active, ventral trunk endoderm cell rearrangements. (2000) (12)
The epidermis is a source of directional information for the migrating pronephric duct in Ambystoma mexicanum embryos. (1995) (12)
Axolotl pronephric duct migration requires an epidermally derived, laminin 1-containing extracellular matrix and the integrin receptorα 6β1 (2003) (11)
Different modes of pronephric duct origin among vertebrates. (1984) (9)
Purification of desmoglein II: a method for the preparation and fractionation of desmosomal components. (1986) (8)
Axolotl pronephric duct migration requires an epidermally derived, laminin 1-containing extracellular matrix and the integrin receptor alpha6beta1. (2003) (8)
Cell surfaces in the control of growth and morphogenesis. (1986) (8)
Reply to Krens et al: Cell stretching may initiate cell differentiation (2011) (3)
An immunoelectron microscopic comparison of desmosomal constituents and hemidesmosomal ones originating from the same tissue of the same animal. (1991) (2)
DIFFERENTIAL ADHESION IN NEURONAL DEVELOPMENT (1986) (2)
Electron microscopic localization of specific carbohydrate groups in thin sections of tissues embedded in a hydrophilic resin: concanavalin A receptors in mouse spleen. (1982) (2)
Foundations of Embryology.Bradley M. Patten (1959) (1)
Hemagglutination by Lectins in Friedreich's Ataxia (1979) (1)
ELECTRIC POTENTIALS AT FOUR POINTS IN A CURRENT-CONDUCTING SLAB DUE TO THE PRESENCE IN THE SLAB OF A SPHERE OF DIFFERING CONDUCTIVITY (1954) (0)
Introduction to the Symposium: The Cell Surface in Development and Cancer (1986) (0)
ON THE SORTING-OUT OF EMBRYONIC CELLS IN MONOLAYER CULTURE (2005) (0)
The Cell Surface as a Regulator of Cell Activities (1986) (0)
An Introduction to Embryology.B. I. Balinsky (1960) (0)
Adhesion-guided mesoderm migration in the living amphibian embryo (1980) (0)
Some Pemphigus Autoantibodies React with Desmosomes (1985) (0)
Patterns in development - cell movement (1981) (0)

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Published Works

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What Schools Are Affiliated With Malcolm Steinberg?

Malcolm Steinberg's AcademicInfluence.com Rankings