Manel Esteller | Academic Influence

Manel Esteller's AcademicInfluence.com Rankings

Manel Esteller

Biology

#573

World Rank

#1007

Historical Rank

Genetics

#44

World Rank

#70

Historical Rank

biology Degrees

Manel Esteller

Philosophy

#1753

World Rank

#3124

Historical Rank

Logic

#306

World Rank

#617

Historical Rank

philosophy Degrees

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Biology
Philosophy

Manel Esteller's Degrees

Doctorate Medicine University of Barcelona
PhD Genetics University of Barcelona

Why Is Manel Esteller Influential?

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According to Wikipedia, Manel Esteller graduated in medicine from the University of Barcelona in 1992, where he also obtained his doctorate, specializing in the molecular genetics of endometrial carcinoma, in 1996. He was an invited researcher at the School of Biological and Medical Sciences at the University of St Andrews, Scotland, during which time his research interests focused on the molecular genetics of inherited breast cancer.

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Manel Esteller's Published Works

Number of citations in a given year to any of this author's works

Total number of citations to an author for the works they published in a given year. This highlights publication of the most important work(s) by the author

Published Works

Non-coding RNAs in human disease (2011) (4064)
Epigenetic differences arise during the lifetime of monozygotic twins. (2005) (3392)
Epigenetic modifications and human disease (2010) (2448)
A gene hypermethylation profile of human cancer. (2001) (2156)
Cancer epigenomics: DNA methylomes and histone-modification maps (2007) (2132)
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. (2000) (2115)
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer (2005) (1822)
Global Epigenomic Reconfiguration During Mammalian Brain Development (2013) (1562)
The Polycomb group protein EZH2 directly controls DNA methylation (2007) (1354)
Epigenetics in cancer. (2008) (1285)
A Landscape of Pharmacogenomic Interactions in Cancer (2016) (1254)
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. (1999) (1244)
CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future (2002) (1207)
Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. (2000) (1188)
Cancer epigenetics reaches mainstream oncology (2011) (1183)
The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors (2003) (1116)
A microRNA DNA methylation signature for human cancer metastasis (2008) (1093)
Gene-expression profiles in hereditary breast cancer. (2001) (1045)
Inactivation of the apoptosis effector Apaf-1 in malignant melanoma (2001) (990)
Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. (1999) (982)
Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome (2011) (954)
Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. (2007) (942)
The Polycomb group protein EZH2 directly controls DNA methylation (2006) (942)
Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. (2001) (939)
The role of histone deacetylases (HDACs) in human cancer (2007) (854)
Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours (2002) (773)
Frequent inactivation of PTEN/MMAC1 in primary prostate cancer. (1997) (759)
Snail Mediates E-Cadherin Repression by the Recruitment of the Sin3A/Histone Deacetylase 1 (HDAC1)/HDAC2 Complex (2004) (726)
Distinct DNA methylomes of newborns and centenarians (2012) (707)
Epigenetic gene silencing in cancer: the DNA hypermethylome. (2007) (699)
DNA methylation profiling in the clinic: applications and challenges (2012) (686)
DNA methylation and cancer. (2010) (670)
Epigenetics and aging: the targets and the marks. (2007) (631)
Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus. (2010) (614)
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. (2002) (605)
DNA methyltransferases control telomere length and telomere recombination in mammalian cells (2006) (604)
Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer. (2000) (574)
Aberrant epigenetic landscape in cancer: how cellular identity goes awry. (2010) (559)
Toward understanding and exploiting tumor heterogeneity (2015) (557)
Gene promoter hypermethylation in tumors and serum of head and neck cancer patients. (2000) (556)
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. (2000) (549)
Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies (2009) (547)
Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features. (2017) (545)
Aberrant DNA methylation as a cancer-inducing mechanism. (2005) (534)
Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status. (2000) (523)
MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas (1998) (522)
lncRNAs and microRNAs with a role in cancer development. (2016) (482)
Validation of a DNA methylation microarray for 850,000 CpG sites of the human genome enriched in enhancer sequences (2015) (479)
Cancer epigenomics: beyond genomics. (2012) (463)
DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. (2001) (461)
Notch signaling is essential for ventricular chamber development. (2007) (459)
DNA methylation: a profile of methods and applications. (2002) (425)
A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function (2009) (405)
Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. (1999) (390)
Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia. (1998) (388)
A systematic profile of DNA methylation in human cancer cell lines. (2003) (374)
A Role for RNAi in the Selective Correction of DNA Methylation Defects (2009) (363)
The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery (2016) (360)
A DNA methylation fingerprint of 1628 human samples. (2011) (359)
DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer (2011) (353)
Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer (2006) (352)
Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis. (2001) (349)
Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin (2005) (347)
Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer. (1999) (343)
A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells. (2010) (341)
Methyl‐CpG binding proteins identify novel sites of epigenetic inactivation in human cancer (2003) (340)
DNA methylation contributes to natural human variation (2013) (337)
Human polymorphism at microRNAs and microRNA target sites. (2013) (330)
Molecular detection of prostate cancer in urine by GSTP1 hypermethylation. (2001) (330)
Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis (2011) (329)
Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers. (2006) (324)
DNA methylomes, histone codes and miRNAs: tying it all together. (2009) (324)
BLUEPRINT to decode the epigenetic signature written in blood (2012) (320)
Relevance of DNA methylation in the management of cancer. (2003) (320)
Epigenetic changes in cancer (2011) (319)
hMLH1 promoter hypermethylation is an early event in human endometrial tumorigenesis. (1999) (315)
SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma. (2003) (315)
Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer (2004) (313)
Cis-acting noncoding RNAs: friends and foes (2012) (311)
Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis. (2016) (311)
Dysregulation of microRNAs in cancer: Playing with fire (2011) (309)
Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation. (1999) (308)
Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma. (2002) (305)
DNA methylation‐based prognosis and epidrivers in hepatocellular carcinoma (2015) (304)
DNA Methylation Polymorphisms Precede Any Histological Sign of Atherosclerosis in Mice Lacking Apolipoprotein E* (2004) (298)
Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. (2003) (297)
Clinical epigenetics: seizing opportunities for translation (2018) (286)
Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of establishment (2014) (280)
A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition (2006) (279)
Epigenetic lesions causing genetic lesions in human cancer: promoter hypermethylation of DNA repair genes. (2000) (271)
Loss of the glycine N‐methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice (2007) (265)
Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. (2006) (265)
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect (2009) (263)
K-ras and p16 aberrations confer poor prognosis in human colorectal cancer. (2001) (260)
GATA-4 and GATA-5 Transcription Factor Genes and Potential Downstream Antitumor Target Genes Are Epigenetically Silenced in Colorectal and Gastric Cancer (2003) (258)
Identification of a mononucleotide repeat as a major target for mitochondrial DNA alterations in human tumors. (2001) (255)
Quantitative comparison of DNA methylation assays for biomarker development and clinical applications (2016) (251)
Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors. (2002) (251)
Histone deacetylase inhibitors: Understanding a new wave of anticancer agents (2004) (251)
Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. (2003) (247)
The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer. (2008) (242)
Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38α in abrogating myoblast proliferation (2007) (239)
Epigenetics provides a new generation of oncogenes and tumour-suppressor genes (2006) (238)
A prognostic DNA methylation signature for stage I non-small-cell lung cancer. (2013) (236)
Allele‐specific histone lysine methylation marks regulatory regions at imprinted mouse genes (2002) (236)
The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties. (2003) (236)
CpG island hypermethylation of tumor suppressor microRNAs in human cancer. (2007) (235)
A Mouse Skin Multistage Carcinogenesis Model Reflects the Aberrant DNA Methylation Patterns of Human Tumors (2004) (235)
The Epigenetic Face of Systemic Lupus Erythematosus1 (2006) (233)
Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study. (2008) (229)
Tumor Cell-Specific BRCA1 and RASSF1A Hypermethylation in Serum, Plasma, and Peritoneal Fluid from Ovarian Cancer Patients (2004) (218)
Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1. (2000) (218)
Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing (2011) (216)
Epigenetic biomarkers for human cancer: the time is now. (2008) (214)
Abnormalities of the APC/β-catenin pathway in endometrial cancer (2002) (213)
Methyl-DNA immunoprecipitation (MeDIP): hunting down the DNA methylome. (2008) (211)
Bromodomain inhibitors and cancer therapy: From structures to applications (2016) (211)
Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors (2003) (210)
Tumor-Related Molecular Mechanisms of Oxaliplatin Resistance (2015) (210)
RNA-RNA interactions in gene regulation: the coding and noncoding players. (2015) (205)
Human DNA Methyltransferase 1 Is Required for Maintenance of the Histone H3 Modification Pattern* (2004) (204)
Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: Relationships with abnormal E‐cadherin and catenin expression and microsatellite instability (2003) (203)
Moving AHEAD with an international human epigenome project (2008) (202)
The Epigenetic Basis of Twin Discordance in Age-Related Diseases (2007) (201)
Cross‐Talk between Aging and Cancer (2007) (199)
Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma (2009) (197)
Low-level microsatellite instability in most colorectal carcinomas. (2002) (197)
Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome (2000) (194)
CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer (2010) (194)
DNA Methylation Map of Human Atherosclerosis (2014) (193)
Lung cancer epigenetics: From knowledge to applications. (2017) (193)
DNA methylation and cancer therapy: new developments and expectations (2005) (192)
E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle‐specific gene transcription (2005) (191)
Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers (1998) (191)
DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load (2019) (186)
Epigenetic alterations involved in cancer stem cell reprogramming (2012) (185)
Intronic RNAs mediate EZH2 regulation of epigenetic targets (2012) (177)
Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer (2016) (177)
The Wnt antagonist DICKKOPF-1 gene is induced by 1alpha,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells. (2007) (174)
A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines (2004) (174)
The necessity of a human epigenome project. (2006) (173)
A microarray-based DNA methylation study of glioblastoma multiforme (2009) (172)
Breast Cancer Epigenetics: From DNA Methylation to microRNAs (2010) (172)
Genome-Wide Analysis of DNA Methylation Differences in Muscle and Fat from Monozygotic Twins Discordant for Type 2 Diabetes (2012) (172)
Towards the Human Cancer Epigenome: A First Draft of Histone Modifications (2005) (170)
Proteins that bind methylated DNA and human cancer: reading the wrong words (2008) (170)
Germ line polymorphisms in cytochrome-P450 1A1 (C4887 CYP1A1) and methylenetetrahydrofolate reductase (MTHFR) genes and endometrial cancer susceptibility. (1997) (169)
Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies. (2009) (168)
Head-to-head antisense transcription and R-loop formation promotes transcriptional activation (2015) (167)
DNA methylation profiling in breast cancer discordant identical twins identifies DOK7 as novel epigenetic biomarker (2012) (164)
Whole-exome sequencing identifies MDH2 as a new familial paraganglioma gene. (2015) (163)
BRCA1 CpG island hypermethylation predicts sensitivity to poly(adenosine diphosphate)-ribose polymerase inhibitors. (2010) (162)
Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes. (2005) (158)
Hypermethylation-associated Inactivation of the Cellular Retinol-Binding-Protein 1 Gene in Human Cancer. (2002) (157)
Sirtuin 1 regulation of developmental genes during differentiation of stem cells (2010) (157)
MGMT hypermethylation: a prognostic foe, a predictive friend. (2007) (156)
Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer (2017) (156)
Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer. (2016) (156)
MicroRNAs and cancer epigenetics: a macrorevolution (2010) (155)
Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA (2015) (155)
CSL–MAML-dependent Notch1 signaling controls T lineage–specific IL-7Rα gene expression in early human thymopoiesis and leukemia (2009) (155)
EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma. (2005) (154)
Cancer Epigenetics and Methylation (2002) (153)
High‐performance capillary electrophoretic method for the quantification of 5‐methyl 2'‐deoxycytidine in genomic DNA: Application to plant, animal and human cancer tissues (2002) (152)
New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling. (2009) (151)
Sarcoma classification by DNA methylation profiling (2021) (147)
Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells (2007) (147)
Abnormalities of the APC/beta-catenin pathway in endometrial cancer. (2002) (147)
A DNA methylation‐based definition of biologically distinct breast cancer subtypes (2014) (145)
Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer. (2005) (144)
An Adenine Code for DNA: A Second Life for N6-Methyladenine (2015) (143)
Profiling aberrant DNA methylation in hematologic neoplasms: a view from the tip of the iceberg. (2003) (143)
Cancer epigenetics: DNA methylation and chromatin alterations in human cancer. (2003) (143)
CpG Island Hypermethylation of the DNA Repair Enzyme Methyltransferase Predicts Response to Temozolomide in Primary Gliomas (2004) (142)
Genetic syndromes caused by mutations in epigenetic genes (2013) (142)
Regulation of pri-miRNA processing by a long noncoding RNA transcribed from an ultraconserved region. (2014) (142)
A profile of methyl-CpG binding domain protein occupancy of hypermethylated promoter CpG islands of tumor suppressor genes in human cancer. (2006) (141)
p14ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2. (2001) (140)
Mutator pathways unleashed by epigenetic silencing in human cancer. (2007) (140)
The impact of chromatin in human cancer: linking DNA methylation to gene silencing. (2002) (140)
Clustering of gene hypermethylation associated with clinical risk groups in neuroblastoma. (2004) (132)
DNA methylation map of mouse and human brain identifies target genes in Alzheimer’s disease (2013) (130)
Epigenetic prediction of response to anti-PD-1 treatment in non-small-cell lung cancer: a multicentre, retrospective analysis. (2018) (130)
Abnormalities of E‐ and P‐cadherin and catenin (β‐, γ‐catenin, and p120ctn) expression in endometrial cancer and endometrial atypical hyperplasia (2003) (129)
Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis (2013) (129)
Inactivation of the lamin A/C gene by CpG island promoter hypermethylation in hematologic malignancies, and its association with poor survival in nodal diffuse large B-cell lymphoma. (2005) (129)
Putative cis-regulatory drivers in colorectal cancer (2014) (128)
Dynamics of DNA Methylation in Recent Human and Great Ape Evolution (2013) (128)
Loss of heterozygosity analysis at the BRCA loci in tumor samples from patients with familial breast cancer (2002) (126)
Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer (2016) (125)
Disrupted microRNA expression caused by Mecp2 loss in a mouse model of Rett syndrome (2010) (124)
A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li–Fraumeni-like families (2015) (123)
Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns (2016) (122)
CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas. (2005) (119)
Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs (2015) (118)
Epigenetic regulation of telomeres in human cancer (2008) (116)
The Epitranscriptome of Noncoding RNAs in Cancer. (2017) (116)
Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia (2001) (115)
Multiple markers for melanoma progression regulated by DNA methylation: insights from transcriptomic studies. (2005) (115)
NID2 and HOXA9 Promoter Hypermethylation as Biomarkers for Prevention and Early Detection in Oral Cavity Squamous Cell Carcinoma Tissues and Saliva (2011) (114)
DNA Methylation Biomarkers for Noninvasive Diagnosis of Colorectal Cancer (2013) (114)
Promoter DNA Hypermethylation and Gene Repression in Undifferentiated Arabidopsis Cells (2008) (114)
BRCA1 epigenetic inactivation predicts sensitivity to platinum-based chemotherapy in breast and ovarian cancer (2012) (113)
H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells (2015) (112)
CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme. (2007) (112)
Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme (2007) (111)
Mecp2-Null Mice Provide New Neuronal Targets for Rett Syndrome (2008) (110)
Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficient in DNA methyltransferases. (2003) (110)
Molecular analysis of a multistep lung cancer model induced by chronic inflammation reveals epigenetic regulation of p16 and activation of the DNA damage response pathway. (2007) (109)
Dormant hypermethylated tumour suppressor genes: questions and answers (2005) (106)
Epigenetic Signatures Associated with Different Levels of Differentiation Potential in Human Stem Cells (2009) (105)
Aberrant promoter methylation of multiple genes throughout the clinico-pathologic spectrum of B-cell neoplasia. (2004) (105)
Genetic and Epigenetic screening for gene alterations of the chromatin‐remodeling factor, SMARCA4/BRG1, in lung tumors (2004) (104)
Unique genomic profile of fibrolamellar hepatocellular carcinoma. (2015) (104)
Epigenetic gene regulation in cancer. (2008) (104)
Silencing of Kruppel-like factor 2 by the histone methyltransferase EZH2 in human cancer (2011) (103)
The dioxin receptor is silenced by promoter hypermethylation in human acute lymphoblastic leukemia through inhibition of Sp1 binding. (2006) (101)
Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer (2007) (100)
CpG island hypermethylation of BRCA1 and loss of pRb as co-occurring events in basal/triple-negative breast cancer (2011) (99)
Discovery of epigenetically silenced genes by methylated DNA immunoprecipitation in colon cancer cells. (2007) (99)
DNA methylation in stem cell renewal and multipotency (2011) (99)
An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins (2014) (99)
Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity (2011) (99)
Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer. (2015) (98)
Promoter CpG Island Hypermethylation of the DNA Repair Enzyme MGMT Predicts Clinical Response to Dacarbazine in a Phase II Study for Metastatic Colorectal Cancer (2013) (97)
Molecular detection of neoplastic cells in lymph nodes of metastatic colorectal cancer patients predicts recurrence. (1999) (97)
Genetic variants in epigenetic genes and breast cancer risk. (2006) (96)
How epigenetics can explain human metastasis: A new role for microRNAs (2009) (95)
Interplay between long non-coding RNAs and epigenetic machinery: emerging targets in cancer? (2018) (95)
The ALFA project: A research platform to identify early pathophysiological features of Alzheimer's disease (2016) (95)
Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR (2015) (95)
A Novel Epigenetic Signature for Early Diagnosis in Lung Cancer (2016) (94)
Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin (2011) (94)
IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation (2016) (92)
Epigenetic Disruption of the PIWI Pathway in Human Spermatogenic Disorders (2012) (91)
A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect (2014) (91)
Cancer Genes Hypermethylated in Human Embryonic Stem Cells (2008) (91)
Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders (2017) (91)
Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN‐1) (2006) (90)
Angiostatic activity of DNA methyltransferase inhibitors (2006) (90)
Chromatin remodeling factor CHD5 is silenced by promoter CpG island hypermethylation in human cancer (2008) (90)
Aberrant DNA methylation in non-small cell lung cancer-associated fibroblasts (2015) (88)
Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations (2018) (88)
IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models. (2016) (87)
Aberrant DNA methylation profiles in the premature aging disorders Hutchinson-Gilford Progeria and Werner syndrome (2013) (87)
Identification of DNA hypermethylation of SOX9 in association with bladder cancer progression using CpG microarrays (2007) (87)
Epigenetic loss of the PIWI/piRNA machinery in human testicular tumorigenesis (2013) (86)
Epigenetic loss of the familial tumor-suppressor gene exostosin-1 (EXT1) disrupts heparan sulfate synthesis in cancer cells. (2004) (86)
MeCP2: the long trip from a chromatin protein to neurological disorders. (2014) (85)
Targeting the histone orthography of cancer: drugs for writers, erasers and readers (2015) (85)
Fatty liver and fibrosis in glycine N‐methyltransferase knockout mice is prevented by nicotinamide (2010) (85)
The DNA methylation drift of the atherosclerotic aorta increases with lesion progression (2015) (85)
Promoter Hypermethylation of the Phosphatase DUSP22 Mediates PKA-Dependent TAU Phosphorylation and CREB Activation in Alzheimer's Disease (2014) (85)
The impact of MECP2 mutations in the expression patterns of Rett syndrome patients (2004) (83)
Hot topics in epigenetic mechanisms of aging: 2011 (2012) (83)
Lurbinectedin (PM01183), a New DNA Minor Groove Binder, Inhibits Growth of Orthotopic Primary Graft of Cisplatin-Resistant Epithelial Ovarian Cancer (2012) (83)
miR-221/222 Target the DNA Methyltransferase MGMT in Glioma Cells (2013) (83)
The Contribution of Epigenetics to Cancer Immunotherapy. (2020) (83)
Abnormalities of E- and P-cadherin and catenin (beta-, gamma-catenin, and p120ctn) expression in endometrial cancer and endometrial atypical hyperplasia. (2003) (82)
Epigenetic Inactivation of the BRCA1 Interactor SRBC and Resistance to Oxaliplatin in Colorectal Cancer (2013) (82)
Transcriptional profiling of MCF7 breast cancer cells in response to 5‐Fluorouracil: Relationship with cell cycle changes and apoptosis, and identification of novel targets of p53 (2006) (82)
DNA Methylation Profiles and Their Relationship with Cytogenetic Status in Adult Acute Myeloid Leukemia (2010) (82)
N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration (2017) (81)
The chromatin remodeling factor CHD8 interacts with elongating RNA polymerase II and controls expression of the cyclin E2 gene (2009) (81)
Epigenetic modifications in breast cancer and their role in personalized medicine. (2013) (80)
How epigenetics can explain human metastasis: a new role for microRNAs. (2009) (80)
Non-coding RNAs, epigenetics, and cancer: tying it all together (2018) (80)
A predictor based on the somatic genomic changes of the BRCA1/BRCA2 breast cancer tumors identifies the non-BRCA1/BRCA2 tumors with BRCA1 promoter hypermethylation. (2005) (79)
5′-CpG island methylation of theLKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer (2000) (79)
Precision medicine based on epigenomics: the paradigm of carcinoma of unknown primary (2017) (79)
Whole-genome bisulfite DNA sequencing of a DNMT3B mutant patient (2012) (79)
Viral epigenomes in human tumorigenesis (2010) (78)
CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas. (2002) (78)
MiR-221 promotes stemness of breast cancer cells by targeting DNMT3b (2015) (78)
Increased loss of chromosome 9p21 but not p16 inactivation in primary non-small cell lung cancer from smokers. (2001) (78)
Aberrant Promoter Methylation of the Transcription Factor Genes PAX5 α and β in Human Cancers (2003) (77)
Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells. (2012) (77)
DNA methylation map in circulating leukocytes mirrors subcutaneous adipose tissue methylation pattern: a genome-wide analysis from non-obese and obese patients (2017) (77)
The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer (2009) (77)
Hypermethylation of a Small CpGuanine-Rich Region Correlates with Loss of Activator Protein-2α Expression during Progression of Breast Cancer (2004) (77)
Impaired DICER1 function promotes stemness and metastasis in colon cancer (2013) (77)
Linkage of DNA methylation quantitative trait loci to human cancer risk. (2014) (76)
Epigenetic Regulation of miR-212 Expression in Lung Cancer (2011) (76)
The absence of p53 is critical for the induction of apoptosis by 5-aza-2′-deoxycytidine (2004) (76)
Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program (2019) (75)
Altered expression of adhesion molecules and epithelial–mesenchymal transition in silica-induced rat lung carcinogenesis (2004) (75)
Effects of APOE-ε4 allele load on brain morphology in a cohort of middle-aged healthy individuals with enriched genetic risk for Alzheimer's disease (2018) (75)
MicroRNA expression profiling and DNA methylation signature for deregulated microRNA in cutaneous T-cell lymphoma. (2015) (75)
Methyl-CpG-binding proteins in cancer: blaming the DNA methylation messenger. (2005) (75)
Susceptibility to endometrial cancer: influence of allelism at p53, glutathione S-transferase (GSTM1 and GSTT1) and cytochrome P-450 (CYP1A1) loci. (1997) (75)
The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors (2016) (74)
Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations (2004) (74)
Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methylation-independent context (2011) (74)
Non‐CpG island promoter hypomethylation and miR‐149 regulate the expression of SRPX2 in colorectal cancer (2013) (74)
Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis (2015) (74)
Epigenome-wide association study of COVID-19 severity with respiratory failure (2021) (73)
Absence of Maternal Methylation in Biparental Hydatidiform Moles from Women with NLRP7 Maternal-Effect Mutations Reveals Widespread Placenta-Specific Imprinting (2015) (73)
Cancer Epigenetics for the 21st Century: What's Next? (2011) (72)
Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer (2010) (71)
Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues (2012) (71)
Novel Insights into DNA Methylation Features in Spermatozoa: Stability and Peculiarities (2012) (70)
The interplay between DNA methylation and sequence divergence in recent human evolution (2015) (69)
Epigenetic control of nuclear architecture (2007) (68)
A DNA methylation map of human cancer at single base-pair resolution (2017) (68)
Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information (2018) (68)
Prenatal antidepressant exposure associated with CYP2E1 DNA methylation change in neonates (2015) (68)
Writers, Readers and Erasers of RNA Modifications in Cancer. (2020) (68)
Detection of Lymph Node Micrometastases by Gene Promoter Hypermethylation in Samples Obtained by Endosonography- Guided Fine-Needle Aspiration Biopsy (2004) (66)
Genome-wide DNA methylation pattern in visceral adipose tissue differentiates insulin-resistant from insulin-sensitive obese subjects. (2016) (66)
Novel methylation panel for the early detection of colorectal tumors in stool DNA. (2010) (66)
S-adenosylmethionine Levels Regulate the Schwann Cell DNA Methylome (2014) (65)
Dysregulation of the long non-coding RNA transcriptome in a Rett syndrome mouse model (2013) (65)
Household SARS-CoV-2 transmission and children: a network prospective study (2021) (65)
Epigenetic disruption of cadherin-11 in human cancer metastasis (2012) (64)
Resistance to Taxanes in Triple-Negative Breast Cancer Associates with the Dynamics of a CD49f+ Tumor-Initiating Population (2017) (64)
The chromatin remodeller CHD8 is required for E2F-dependent transcription activation of S-phase genes (2013) (63)
Abnormal PcG protein expression in Hodgkin's lymphoma. Relation with E2F6 and NFκB transcription factors (2004) (63)
The novel DNA methylation inhibitor zebularine is effective against the development of murine T-cell lymphoma. (2006) (63)
Molecular-Subtype-Specific Biomarkers Improve Prediction of Prognosis in Colorectal Cancer. (2017) (63)
Altered expression of the imprinted transcription factor PLAGL1 deregulates a network of genes in the human IUGR placenta. (2014) (62)
Epigenetic inactivation of tumour suppressor coding and non-coding genes in human cancer: an update (2017) (62)
Aberrant promoter methylation of the transcription factor genes PAX5 alpha and beta in human cancers. (2003) (62)
Regulation of DNA methylation patterns by CK2-mediated phosphorylation of Dnmt3a. (2014) (62)
A comprehensive DNA methylation profile of epithelial-to-mesenchymal transition. (2014) (61)
PM20D1 is a quantitative trait locus associated with Alzheimer’s disease (2018) (61)
Whole exome sequencing of Rett syndrome-like patients reveals the mutational diversity of the clinical phenotype (2016) (61)
DNA Methylation and Histone Modifications in Patients With Cancer (2007) (61)
Targeted Exome Sequencing of Krebs Cycle Genes Reveals Candidate Cancer–Predisposing Mutations in Pheochromocytomas and Paragangliomas (2017) (61)
Unmasking of epigenetically silenced candidate tumor suppressor genes by removal of methyl-CpG-binding domain proteins (2008) (60)
Transcriptional targets of the chromatin-remodelling factor SMARCA4/BRG1 in lung cancer cells. (2005) (60)
Alterations of the p16/Rb/cyclin-D1 pathway in vulvar carcinoma, vulvar intraepithelial neoplasia, and lichen sclerosus. (2002) (59)
The DNA methylome of glioblastoma multiforme (2010) (59)
Epigenetic inactivation of the Groucho homologue gene TLE1 in hematologic malignancies. (2008) (57)
Epigenomics of human colon cancer. (2010) (57)
CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer (2004) (57)
TRIM28 and Interacting KRAB-ZNFs Control Self-Renewal of Human Pluripotent Stem Cells through Epigenetic Repression of Pro-differentiation Genes (2017) (57)
Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer (2016) (57)
Comprehensive DNA methylation study identifies novel progression-related and prognostic markers for cutaneous melanoma (2017) (57)
CpG island hypermethylation-associated silencing of small nucleolar RNAs in human cancer (2012) (57)
MicroRNAs and Epigenetics (2017) (57)
Profiling epigenetic alterations in disease. (2011) (57)
The impact of pro-inflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes (2019) (56)
Immunohistochemical classification of non-BRCA1/2 tumors identifies different groups that demonstrate the heterogeneity of BRCAX families (2007) (56)
BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma (2015) (56)
Hypermethylation of the proapoptotic gene TMS1/ASC: prognostic importance in glioblastoma multiforme (2007) (56)
Validation of DNA methylation profiling in formalin-fixed paraffin-embedded samples using the Infinium HumanMethylation450 Microarray (2014) (55)
Genetic and epigenetic profile of sporadic pheochromocytomas (2004) (55)
The Breast Cancer Oncogene EMSY Represses Transcription of Antimetastatic microRNA miR-31 (2014) (54)
Checkpoint kinase 1 (CHK1) protein and mRNA expression is downregulated in aggressive variants of human lymphoid neoplasms (2005) (54)
Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations. (2008) (54)
Epigenetics provides a new generation of oncogenes and tumour-suppressor genes. (2007) (54)
Frequent loss of endothelin-3 (EDN3) expression due to epigenetic inactivation in human breast cancer (2009) (53)
MiR-193b promoter methylation accurately detects prostate cancer in urine sediments and miR-34b/c or miR-129-2 promoter methylation define subsets of clinically aggressive tumors (2017) (53)
The RNA-binding protein HuR regulates DNA methylation through stabilization of DNMT3b mRNA (2009) (53)
Loss of E‐cadherin mediated cell–cell adhesion as an early trigger of apoptosis induced by photodynamic treatment (2005) (52)
The PDGFRβ–AKT Pathway Contributes to CDDP-Acquired Resistance in Testicular Germ Cell Tumors (2013) (52)
Opening up the DNA methylome of dementia (2017) (52)
Arachidonic and oleic acid exert distinct effects on the DNA methylome (2016) (51)
The B cell transcription program mediates hypomethylation and overexpression of key genes in Epstein-Barr virus-associated proliferative conversion (2013) (51)
DNA demethylating agents and chromatin-remodelling drugs: which, how and why? (2003) (51)
Metallothionein 1E is methylated in malignant melanoma and increases sensitivity to cisplatin-induced apoptosis (2010) (51)
Epigenetic Activation of SOX11 in Lymphoid Neoplasms by Histone Modifications (2011) (51)
KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer. (2015) (51)
How epigenetics integrates nuclear functions (2005) (50)
Methylation of p 16 INK 4 a Promoters Occurs in Vivo in Histologically Normal Human Mammary Epithelia 1 (2003) (50)
Mammalian HP1 Isoforms Have Specific Roles in Heterochromatin Structure and Organization. (2017) (50)
Downregulation of miR-130b~301b cluster is mediated by aberrant promoter methylation and impairs cellular senescence in prostate cancer (2017) (49)
Molecular portrait of high alpha-fetoprotein in hepatocellular carcinoma: implications for biomarker-driven clinical trials (2019) (49)
DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia (2015) (49)
DNA methylation and histone modifications in patients with cancer: potential prognostic and therapeutic targets. (2007) (48)
MicroRNA-654-5p suppresses ovarian cancer development impacting on MYC, WNT and AKT pathways (2019) (48)
Differential hypermethylation of genes in vulvar cancer and lichen sclerosus coexisting or not with vulvar cancer (2011) (48)
Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19 (2021) (47)
Disruption of microRNA nuclear transport in human cancer. (2014) (47)
The clinicopathological significance of K-RAS point mutation and gene amplification in endometrial cancer. (1997) (47)
A TARBP 2 mutation in human cancer impairs microRNA processing and DICER 1 function (2009) (46)
Specific hypermethylation of LINE-1 elements during abnormal overgrowth and differentiation of human placenta (2007) (46)
Long-Range Epigenetic Silencing Associates with Deregulation of Ikaros Targets in Colorectal Cancer Cells (2011) (46)
Accelerated biological aging in COVID-19 patients (2022) (46)
An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures (2017) (45)
The epigenetic breakdown of cancer cells: from DNA methylation to histone modifications. (2005) (45)
A precursor microRNA in a cancer cell nucleus (2011) (45)
SnapShot: Messenger RNA Modifications (2018) (45)
Epigenetics in evolution and disease (2008) (44)
The NCI-60 Methylome and Its Integration into CellMiner. (2017) (44)
Combinatorial effects of splice variants modulate function of Aiolos (2007) (44)
MiR-204 silencing in intraepithelial to invasive cutaneous squamous cell carcinoma progression (2016) (44)
DNA methylation determines nucleosome occupancy in the 5′-CpG islands of tumor suppressor genes (2013) (44)
DNA methylation and the functional organization of the nuclear compartment. (2010) (44)
DNA methylation-based reclassification of olfactory neuroblastoma (2018) (43)
The Inescapable Influence of Noncoding RNAs in Cancer. (2015) (42)
Identification of Tri‐ and Tetracyclic Pyrimidinediones as Sirtuin Inhibitors (2010) (42)
Cancer genomics identifies disrupted epigenetic genes (2014) (42)
Variable maternal methylation overlapping the nc886/vtRNA2-1 locus is locked between hypermethylated repeats and is frequently altered in cancer (2014) (42)
Polychlorinated biphenyls affect histone modification pattern in early development of rats: a role for androgen receptor-dependent modulation? (2012) (42)
Cancer Detection and Prognosis (2006) (42)
The PEG13-DMR and brain-specific enhancers dictate imprinted expression within the 8q24 intellectual disability risk locus (2014) (42)
Identification of PMF1 Methylation in Association with Bladder Cancer Progression (2008) (41)
Differences and molecular immunohistochemical parameters in the subtypes of infiltrating ductal breast cancer. (2008) (41)
Merkel cell carcinoma of the vulva. (1997) (41)
The epigenetic landscape of Alu repeats delineates the structural and functional genomic architecture of colon cancer cells (2016) (41)
Chromatin remodeling in mammary gland differentiation and breast tumorigenesis. (2010) (41)
Associations between whole peripheral blood fatty acids and DNA methylation in humans (2016) (40)
Transforming pathways unleashed by a HDAC2 mutation in human cancer (2008) (40)
Novel Methylation Panel for the Early Detection of Neoplasia in High-risk Ulcerative Colitis and Crohn's Colitis Patients (2013) (39)
WNT10B functional dualism: beta-catenin/Tcf-dependent growth promotion or independent suppression with deregulated expression in cancer. (2007) (39)
Stepwise analysis of MIR9 loci identifies miR-9-5p to be involved in Oestrogen regulated pathways in breast cancer patients (2017) (39)
Advances in the molecular genetics of endometrial cancer (Review). (1999) (38)
Wnt signaling promoter hypermethylation distinguishes lung primary adenocarcinomas from colorectal metastasis to the lung (2006) (38)
Histone H1 depletion triggers an interferon response in cancer cells via activation of heterochromatic repeats (2017) (38)
DNA Methylomes Reveal Biological Networks Involved in Human Eye Development, Functions and Associated Disorders (2017) (38)
Molecular Features of Cancers Exhibiting Exceptional Responses to Treatment. (2020) (38)
Inactivation of the tissue inhibitor of metalloproteinases-2 gene by promoter hypermethylation in lymphoid malignancies (2005) (38)
Epigenetic changes associated with neoplasms of the exocrine and endocrine pancreas. (2014) (38)
Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism (2017) (38)
Epigenetic inactivation of the splicing RNA-binding protein CELF2 in human breast cancer (2019) (37)
Epigenetic Alterations of the Wnt/β -Catenin Pathway in Human Disease (2007) (37)
A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97 (2018) (37)
Epigenetic control of influenza virus: role of H3K79 methylation in interferon-induced antiviral response (2018) (37)
Assessing Associations between the AURKA-HMMR-TPX2-TUBG1 Functional Module and Breast Cancer Risk in BRCA1/2 Mutation Carriers (2015) (37)
DNMT3B gene amplification predicts resistance to DNA demethylating drugs (2011) (37)
White matter microstructure is altered in cognitively normal middle-aged APOE-ε4 homozygotes (2018) (36)
Detection of clonality and genetic alterations in endometrial pipelle biopsy and its surgical specimen counterpart. (1997) (36)
A new approach to epigenome-wide discovery of non-invasive methylation biomarkers for colorectal cancer screening in circulating cell-free DNA using pooled samples (2018) (36)
Identification of an episignature of human colorectal cancer associated with obesity by genome-wide DNA methylation analysis (2018) (36)
The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent let-7 inhibition (2019) (36)
Recruitment of CREB1 and histone deacetylase 2 (HDAC2) to the mouse Ltbp-1 promoter regulates its constitutive expression in a dioxin receptor-dependent manner. (2008) (36)
Impaired recruitment of the histone methyltransferase DOT1L contributes to the incomplete reactivation of tumor suppressor genes upon DNA demethylation (2009) (36)
SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway (2018) (36)
VAV3 mediates resistance to breast cancer endocrine therapy (2014) (35)
BCR‐ABL1‐induced expression of HSPA8 promotes cell survival in chronic myeloid leukaemia (2008) (35)
Epigenetic profiling joins personalized cancer medicine (2013) (35)
Notch1 Pathway Activation Results from the Epigenetic Abrogation of Notch-Related MicroRNAs in Mycosis Fungoides. (2015) (35)
A two-gene epigenetic signature for the prediction of response to neoadjuvant chemotherapy in triple-negative breast cancer patients (2019) (35)
Genomic p16 abnormalities in the progression of chronic myeloid leukemia into blast crisis: a sequential study in 42 patients. (2003) (35)
Household Severe Acute Respiratory Syndrome Coronavirus 2 Transmission and Children: A Network Prospective Study (2021) (35)
Human native lipoprotein-induced de novo DNA methylation is associated with repression of inflammatory genes in THP-1 macrophages (2011) (35)
Mutations in JMJD1C are involved in Rett syndrome and intellectual disability (2015) (35)
DNA methylation plasticity of human adipose-derived stem cells in lineage commitment. (2012) (35)
Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice. (2018) (34)
Lack of Methylthioadenosine Phosphorylase Expression in Mantle Cell Lymphoma Is Associated with Shorter Survival: Implications for a Potential Targeted Therapy (2006) (34)
Methylation status of the p15, p16 and MGMT promoter genes in primary cutaneous T-cell lymphomas. (2004) (34)
Epigenetic Homogeneity Within Colorectal Tumors Predicts Shorter Relapse-Free and Overall Survival Times for Patients With Locoregional Cancer. (2016) (34)
Obesity and menopause modify the epigenomic profile of breast cancer. (2017) (34)
Multiple binding of methyl‐CpG and polycomb proteins in long‐term gene silencing events (2007) (34)
Cyclooxygenase 2 Expression in Colorectal Cancer with DNA Mismatch Repair Deficiency (2006) (33)
Quantification of global DNA methylation by capillary electrophoresis and mass spectrometry. (2009) (33)
Release of Hypoacetylated and Trimethylated Histone H4 Is an Epigenetic Marker of Early Apoptosis* (2006) (33)
DNA Hypomethylation Affects Cancer-Related Biological Functions and Genes Relevant in Neuroblastoma Pathogenesis (2012) (33)
Tumor MGMT promoter hypermethylation changes over time limit temozolomide efficacy in a phase II trial for metastatic colorectal cancer. (2016) (33)
In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development (2016) (33)
The transcriptional repressor HDAC7 promotes apoptosis and c-Myc downregulation in particular types of leukemia and lymphoma (2015) (33)
MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2 (2018) (32)
EPHA7, a new target gene for 6q deletion in T-cell lymphoblastic lymphomas. (2012) (32)
How epigenetics integrates nuclear functions. Workshop on epigenetics and chromatin: transcriptional regulation and beyond. (2005) (32)
Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition (2016) (32)
Epigenetic alterations of the Wnt/beta-catenin pathway in human disease. (2007) (31)
Advances in Brief Inactivation of the DNA Repair Gene O 6-Methylguanine-DNA Methyltransferase by Promoter Hypermethylation is a Common Event in Primary Human Neoplasia 1 (1999) (31)
Epigenetics in Schizophrenia: A Pilot Study of Global DNA Methylation in Different Brain Regions Associated with Higher Cognitive Functions (2016) (31)
Modeling lung cancer evolution and preclinical response by orthotopic mouse allografts. (2014) (31)
Clinicopathologic features and genetic alterations in endometrioid carcinoma of the uterus with villoglandular differentiation. (1999) (30)
Epigenetic connections between autoimmune disorders and haematological malignancies. (2008) (30)
DNA methylation in early neoplasia. (2010) (30)
Label-free DNA-methylation detection by direct ds-DNA fragment screening using poly-purine hairpins. (2018) (30)
Epigenetic silencing of TGFBI confers resistance to trastuzumab in human breast cancer (2019) (30)
Genome-wide DNA methylation profiling predicts relapse in childhood B-cell acute lymphoblastic leukaemia (2012) (30)
Circular RNA CpG island hypermethylation-associated silencing in human cancer (2018) (29)
Global DNA methylation: a common early event in oral cancer cases with exposure to environmental carcinogens or viral agents. (2009) (29)
Epigenetic alterations leading to TMPRSS4 promoter hypomethylation and protein overexpression predict poor prognosis in squamous lung cancer patients (2016) (29)
Clinical and molecular analyses of Beckwith–Wiedemann syndrome: Comparison between spontaneous conception and assisted reproduction techniques (2016) (29)
Epigenetics in Biology and Medicine (2008) (29)
CHL1 hypermethylation as a potential biomarker of poor prognosis in breast cancer (2017) (28)
RASSF2 hypermethylation is present and related to shorter survival in squamous cervical cancer (2013) (28)
CD137 (4-1BB) Costimulation Modifies DNA Methylation in CD8+ T Cell–Relevant Genes (2017) (28)
Walking pathways with positive feedback loops reveal DNA methylation biomarkers of colorectal cancer (2019) (28)
DNA methylation signal has a major role in the response of human breast cancer cells to the microenvironment (2017) (27)
CpG island methylation and histone modifications: biology and clinical significance. (2006) (27)
DNA methylation biomarkers of myocardial infarction and cardiovascular disease (2019) (27)
DNA Methylation Dynamics in Human Carotid Plaques After Cerebrovascular Events (2015) (27)
Epigenetic inactivation of the ERK inhibitor Spry2 in B-cell diffuse lymphomas (2008) (26)
Genome-Wide DNA Methylation Analysis Identifies Novel Hypomethylated Non-Pericentromeric Genes with Potential Clinical Implications in ICF Syndrome (2015) (26)
DNA repair capacity is impaired in healthy BRCA1 heterozygous mutation carriers (2015) (26)
DNA methylation profiling identifies PTRF/Cavin-1 as a novel tumor suppressor in Ewing sarcoma when co-expressed with caveolin-1. (2017) (26)
Disruption of the RNA modifications that target the ribosome translation machinery in human cancer (2020) (26)
New therapeutic targets in cancer: the epigenetic connection (2006) (26)
A multi‐omic study reveals BTG2 as a reliable prognostic marker for early‐stage non‐small cell lung cancer (2018) (26)
Epigenetic modifications and human (2010) (25)
Triple Negative Breast Cancer in the Era of miRNA. (2020) (25)
The expression of CSRP2 encoding the LIM domain protein CRP2 is mediated by TGF-beta in smooth muscle and hepatic stellate cells. (2006) (25)
Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors (2017) (25)
The Epigenomic Revolution in Breast Cancer: From Single-Gene to Genome-Wide Next-Generation Approaches. (2017) (25)
Effect of genetic ancestry on leukocyte global DNA methylation in cancer patients (2015) (25)
Characterization of 8 p 21 . 3 chromosomal deletions in B-cell lymphoma : TRAIL-R 1 and TRAIL-R 2 as candidate dosage-dependent tumor suppressor genes (2005) (25)
Aberrant epigenetic landscape in intellectual disability. (2012) (24)
Epigenetic Regulation of Vitamin D Metabolism in Human Lung Adenocarcinoma (2014) (24)
NuRD-dependent DNA methylation prevents ES cells from accessing a trophectoderm fate (2012) (24)
Use of DNA Methylation Profiling in Translational Oncology. (2020) (24)
Detection of c‐erbB‐2/neu and fibroblast growth factor‐3/INT‐2 but not epidermal growth factor receptor gene amplification in endometrial cancer by differential polymerase chain reaction (1995) (23)
Germline mutations in the spindle assembly checkpoint genes BUB1 and BUB3 are infrequent in familial colorectal cancer and polyposis (2018) (23)
Epigenetic EGFR Gene Repression Confers Sensitivity to Therapeutic BRAFV600E Blockade in Colon Neuroendocrine Carcinomas (2019) (23)
Impaired in vivo binding of MeCP2 to chromatin in the absence of its DNA methyl-binding domain (2013) (23)
Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control (2020) (23)
EZH2-mediated epigenetic repression of DNA repair in promoting breast tumor initiating cells (2011) (23)
DNA Methylation Profiling of Human Hepatocarcinogenesis (2020) (23)
In vivo analysis of DNA methylation patterns recognized by specific proteins: coupling CHIP and bisulfite analysis. (2004) (23)
Differences in expression rather than methylation at placenta-specific imprinted loci is associated with intrauterine growth restriction (2019) (22)
Cancer Stem-like Cells Act via Distinct Signaling Pathways in Promoting Late Stages of Malignant Progression. (2016) (22)
Towards a more precise therapy in cancer: Exploring epigenetic complexity. (2020) (22)
The role of ZFP57 and additional KRAB-zinc finger proteins in the maintenance of human imprinted methylation and multi-locus imprinting disturbances (2020) (22)
Genomic and Molecular Screenings Identify Different Mechanisms for Acquired Resistance to MET Inhibitors in Lung Cancer Cells (2017) (22)
Hypermethylation of the alternative AWT1 promoter in hematological malignancies is a highly specific marker for acute myeloid leukemias despite high expression levels (2014) (22)
Identification of HERC5 and its potential role in NSCLC progression (2015) (22)
Directing neuronal cell fate in vitro: Achievements and challenges (2018) (22)
SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1 (2020) (21)
Disruption of Long Noncoding RNAs Targets Cancer Hallmark Pathways in Lung Tumorigenesis. (2019) (21)
Hsa-miR-155-5p Up-Regulation in Breast Cancer and Its Relevance for Treatment With Poly[ADP-Ribose] Polymerase 1 (PARP-1) Inhibitors (2020) (21)
Caveolin-1 is down-regulated in alveolar rhabdomyosarcomas and negatively regulates tumor growth (2014) (21)
Epigenetic loss of the transfer RNA-modifying enzyme TYW2 induces ribosome frameshifts in colon cancer (2020) (21)
Generation and Characterization of Rat and Mouse Monoclonal Antibodies Specific for MeCP2 and Their Use in X-Inactivation Studies (2011) (21)
Advances in Brief Inactivation of the DNA Repair Gene O 6-Methylguanine-DNA Methyltransferase by Promoter Hypermethylation Is Associated with G to A Mutations in Kras in Colorectal Tumorigenesis 1 (2000) (21)
Erratum: Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis (2016) (21)
DNA Hypermethylation in Somatic Cells Correlates with Higher Reprogramming Efficiency (2012) (20)
Improvement of the Rett Syndrome Phenotype in a Mecp2 Mouse Model Upon Treatment with Levodopa and a Dopa-Decarboxylase Inhibitor (2014) (20)
An increase in MECP2 dosage impairs neural tube formation (2014) (20)
Capillary electrophoresis-based method to quantitate DNA-protein interactions. (2003) (20)
Array‐based DNA methylation profiling in acute myeloid leukaemia (2011) (20)
EGLN2 DNA methylation and expression interact with HIF1A to affect survival of early-stage NSCLC (2019) (20)
DNA methylation, epigenetics, and metastasis (2005) (20)
Profiling of oxBS-450K 5-hydroxymethylcytosine in human placenta and brain reveals enrichment at imprinted loci (2018) (20)
Higher prevalence of cerebral white matter hyperintensities in homozygous APOE-ɛ4 allele carriers aged 45–75: Results from the ALFA study (2017) (20)
The activatory long non-coding RNA DBE-T reveals the epigenetic etiology of facioscapulohumeral muscular dystrophy (2012) (19)
Identification of (1H)-pyrroles as histone deacetylase inhibitors with antitumoral activity (2009) (19)
Moving Closer to a Prognostic DNA Methylation Signature in Colon Cancer (2011) (19)
At the crossroad of lifespan, calorie restriction, chromatin and disease: Meeting on sirtuins (2010) (19)
Circadian Cycle-Dependent MeCP2 and Brain Chromatin Changes (2015) (19)
Polyamines affect histamine synthesis during early stages of IL‐3‐induced bone marrow cell differentiation (2009) (19)
An Epigenetic Signature in Adipose Tissue Is Linked to Nicotinamide N‐Methyltransferase Gene Expression (2018) (19)
EZH2: an epigenetic gatekeeper promoting lymphomagenesis. (2013) (19)
Characterization of parent-of-origin methylation using the Illumina Infinium MethylationEPIC array platform. (2018) (19)
High rate of MDR‐1 and heterogeneous pattern of MRP expression without gene amplification in endometrial cancer (1995) (19)
Loss of chromosome arms 3p and 9p and inactivation of P16 INK4a in normal epithelium of patients with primary lung cancer (2001) (19)
Bivalent histone modifications in stem cells poise miRNA loci for CpG island hypermethylation in human cancer (2011) (18)
Identification of 20 novel loci associated to ischemic stroke. Epigenome-Wide Association Study (2019) (18)
A novel Werner Syndrome mutation: pharmacological treatment by read-through of nonsense mutations and epigenetic therapies (2015) (18)
Epigenetic SMAD3 repression in tumor-associated fibroblasts impairs fibrosis and response to the antifibrotic drug nintedanib in lung squamous cell carcinoma. (2019) (18)
Epigenetic Loss of m1A RNA Demethylase ALKBH3 in Hodgkin Lymphoma Targets Collagen Conferring Poor Clinical Outcome. (2020) (18)
Hsa-miR-210-3p expression in breast cancer and its putative association with worse outcome in patients treated with Docetaxel (2019) (18)
Extraordinary Cancer Epigenomics: Thinking Outside the Classical Coding and Promoter Box. (2016) (18)
The DNA methylation landscape of hematological malignancies: an update (2020) (17)
MethCORR modelling of methylomes from formalin-fixed paraffin-embedded tissue enables characterization and prognostication of colorectal cancer (2020) (17)
Interactive effect of age and APOE-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects (2019) (17)
Clinicopathologic and molecular analysis of embryonal rhabdomyosarcoma of the genitourinary tract: evidence for a distinct DICER1-associated subgroup (2021) (17)
A Gene Hypermethylation Profile of Human Cancer 1 (2001) (17)
Epigenetic loss of the endoplasmic reticulum-associated degradation inhibitor SVIP induces cancer cell metabolic reprogramming. (2019) (16)
Epigenetic Profiling and Response to CD19 Chimeric Antigen Receptor T-Cell Therapy in B-Cell Malignancies (2021) (16)
Combined analysis of miR-200 family and its significance for breast cancer (2021) (16)
Bromodomain inhibition shows antitumoral activity in mice and human luminal breast cancer. (2017) (16)
A combined epigenetic therapy equals the efficacy of conventional chemotherapy in refractory advanced non-small cell lung cancer. (2011) (16)
Metformin pharmacogenomics: a genome-wide association study to identify genetic and epigenetic biomarkers involved in metformin anticancer response using human lymphoblastoid cell lines. (2016) (16)
A Role for Methyl-CpG Binding Domain Protein 2 in the Modulation of the Estrogen Response of pS2/TFF1 Gene (2010) (16)
The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes (2019) (15)
CpG Islands in Cancer: Heads, Tails, and Sides. (2018) (15)
The Altered Transcriptome and DNA Methylation Profiles of Docetaxel Resistance in Breast Cancer PDX Models (2019) (15)
Independent Validation of Early-Stage Non-Small Cell Lung Cancer Prognostic Scores Incorporating Epigenetic and Transcriptional Biomarkers With Gene-Gene Interactions and Main Effects (2020) (15)
SIPA1L3 methylation modifies the benefit of smoking cessation on lung adenocarcinoma survival: an epigenomic–smoking interaction analysis (2019) (15)
The DNA methylation landscape of human cancer organoids available at the American type culture collection (2020) (15)
Epigenomic signature of adrenoleukodystrophy predicts compromised oligodendrocyte differentiation (2018) (15)
The intervening domain from MeCP2 enhances the DNA affinity of the methyl binding domain and provides an independent DNA interaction site (2017) (15)
Epigenetic loss of the RNA decapping enzyme NUDT16 mediates C-MYC activation in T-cell acute lymphoblastic leukemia (2017) (15)
SnapShot: The Human DNA Methylome in Health and Disease (2008) (15)
Epigenetic modifications in KDM lysine demethylases associate with survival of early-stage NSCLC (2018) (14)
Common genetic evolutionary pathways in familial adenomatous polyposis tumors. (2003) (14)
Standardized approach for microsatellite instability detection in gastric carcinomas. (2004) (14)
Circulating Cell-Free DNA in Breast Cancer: Searching for Hidden Information towards Precision Medicine (2021) (13)
In vitro and in vivo activity of a new small-molecule inhibitor of HDAC6 in mantle cell lymphoma (2018) (13)
APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals (2019) (13)
Oncometabolite Accumulation and Epithelial-to-Mesenchymal Transition: The Turn of Fumarate. (2016) (13)
Inactivation of LKB 1 / STK 11 Is a Common Event in Adenocarcinomas of the Lung 1 (2002) (13)
Trans-omics biomarker model improves prognostic prediction accuracy for early-stage lung adenocarcinoma (2019) (13)
CpG Island Methylation ′ Associated with 5 Lymphoblastic Leukemia and Burkitt ' s Lymphoma Is Gene in Acute p 73 Transcriptional Silencing of the Updated Version (1999) (13)
Erratum: DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia (2016) (13)
Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness (2015) (13)
Genome-Wide and Gene-Specific Epigenomic Platforms for Hepatocellular Carcinoma Biomarker Development Trials (2014) (13)
The DEXLIFE study methods: identifying novel candidate biomarkers that predict progression to type 2 diabetes in high risk individuals. (2014) (12)
Disruption of NIPBL/Scc2 in Cornelia de Lange Syndrome provokes cohesin genome-wide redistribution with an impact in the transcriptome (2021) (12)
Germline variation in O6-methylguanine-DNA methyltransferase (MGMT) as cause of hereditary colorectal cancer. (2019) (12)
The Exceptional Responders Initiative: Feasibility of A National Cancer Institute Pilot Study. (2020) (12)
Orthoxenografts of Testicular Germ Cell Tumors Demonstrate Genomic Changes Associated with Cisplatin Resistance and Identify PDMP as a Resensitizing Agent (2018) (12)
Rett Syndrome: The First Forty Years 1966-2006 (2007) (11)
Beyond Genetics—The Emerging Role of Epigenetic Changes in Hematopoietic Malignancies (2004) (11)
DNA methylation : approaches, methods, and applications (2004) (11)
Epigenetic silencing of E- and N-cadherins in the stroma of mouse thymic lymphomas. (2006) (11)
DNA Methylation Markers for Prostate Cancer with a Stem Cell Twist (2010) (11)
HIGHER PREVALENCE OF CEREBRAL WHITE MATTER HYPERINTENSITIES IN HOMOZYGOUS APOE-ε4 ALLELE CARRIERS AGED 45 TO 75: RESULTS FROM THE ALFA STUDY (2017) (11)
Cancer, epigenetics and the Nobel Prizes (2012) (10)
A synthetic mRNA cell reprogramming method using CYCLIN D1 promotes DNA repair, generating improved genetically stable human induced pluripotent stem cells (2021) (10)
DNA Methylation of LRRC3B: A Biomarker for Survival of Early-Stage Non–Small Cell Lung Cancer Patients (2018) (10)
Epigenetic control of somatostatin and cortistatin expression by β amyloid peptide (2012) (10)
CHK 2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas (2002) (10)
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one (2016) (10)
DNA methylation plasticity contributes to the natural history of metastasis (2015) (10)
Epigenetic–smoking interaction reveals histologically heterogeneous effects of TRIM27 DNA methylation on overall survival among early‐stage NSCLC patients (2020) (10)
Barcelona conference on epigenetics and cancer: 50 years of histone acetylation (2015) (10)
Whole genome grey and white matter DNA methylation profiles in dorsolateral prefrontal cortex (2017) (9)
The loss of NKX3.1 expression in testicular – and prostate – cancers is not caused by promoter hypermethylation (2005) (9)
The Genome-wide Methylation Profile of CD4+ T Cells From Individuals With Human Immunodeficiency Virus (HIV) Identifies Distinct Patterns Associated With Disease Progression (2020) (9)
B-cell leukemia transdifferentiation to macrophage involves reconfiguration of DNA methylation for long-range regulation (2019) (9)
MAX mutant small-cell lung cancers exhibit impaired activities of MGA-dependent noncanonical polycomb repressive complex (2021) (8)
Rolling the dice to discover the role of DICER in tumorigenesis. (2012) (8)
The coming of age of DNA methylation in medicine in the genomics and postgenomics era. (2002) (8)
DNA methylation alterations in grade II- and anaplastic pleomorphic xanthoastrocytoma (2014) (8)
Thyroid hormone stimulates phosphoglycerate mutase activity and isozyme transition in rat muscle tissues. (1994) (8)
Epitranscriptomics in Hematopoiesis and Hematologic Malignancies. (2020) (8)
Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect (2009) (8)
Acute lymphoblastic leukemia necessitates GSH-dependent ferroptosis defenses to overcome FSP1-epigenetic silencing (2022) (7)
Impact of DNA Methylation on Health and Disease (2004) (7)
A Tumor Suppressor Enhancer of PTEN in T-cell development and leukemia. (2020) (7)
Dynamics of bivalent chromatin domains upon drug induced reactivation and resilencing in cancer cells (2011) (7)
DNA Methylation and Histone Acetylation (2006) (7)
Germline variation in O-methylguanine-DNA methyltransferase (MGMT) as cause of hereditary colorectal cancer (2019) (7)
Towards a druggable epitranscriptome: Compounds that target RNA modifications in cancer (2021) (7)
Lurbinectedin ( PM 01183 ) , a New DNA Minor Groove Binder , Inhibits Growth of Orthotopic Primary Graft of Cisplatin-Resistant Epithelial Ovarian Cancer (2012) (7)
First Barcelona Conference on Epigenetics and Cancer (2014) (7)
The impact of pro-inflammatory cytokines on the β-cell regulatory landscape provides new insights into the genetics of type 1 diabetes (2019) (7)
Mouse models in epigenetics: insights in development and disease. (2013) (7)
Genome-wide DNA methylation profiling in early stage I lung adenocarcinoma reveals predictive aberrant methylation in the promoter region of the long non-coding RNA PLUT - an exploratory study. (2020) (7)
Global Proteomic and Methylome Analysis in Human Induced Pluripotent Stem Cells Reveals Overexpression of a Human TLR3 Affecting Proper Innate Immune Response Signaling (2019) (7)
BRCA1 as a tumor suppressor linked to the regulation of epigenetic states: keeping oncomiRs under control (2012) (7)
Single cell cancer epigenetics. (2022) (7)
Cancer network activity associated with therapeutic response and synergism (2016) (7)
Endometrial carcinoma in tamoxifen-treated breast cancer patient: clinicopathological, immunohistochemical, and genetic analysis. (1999) (7)
Antitumor Activity of the Novel BTK Inhibitor TG-1701 Is Associated with Disruption of Ikaros Signaling in Patients with B-cell Non–Hodgkin Lymphoma (2021) (7)
Oxidation of carboxyamidomethyl cysteine may add complexity to protein identification (2005) (6)
Microsatellite instability in IBD-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, HMLH1 (2000) (6)
Epigenome-wide gene–age interaction analysis reveals reversed effects of PRODH DNA methylation on survival between young and elderly early-stage NSCLC patients (2020) (6)
Bromodomain inhibition shows antitumoral activity in mice and human luminal breast cancer (2017) (6)
Distinct Associations of BMI and Fatty Acids With DNA Methylation in Fasting and Postprandial States in Men (2021) (6)
Towards a “druggable” epitranscriptome: Compounds that target RNA modifications in cancer (2020) (6)
Sensitization of retinoids and corticoids to epigenetic drugs in MYC-activated lung cancers by antitumor reprogramming (2017) (6)
Introduction: Epigenetics in cancer. (2018) (6)
Study of breast cancer incidence in patients of lymphangioleiomyomatosis (2016) (6)
Validation of a DNA methylation microarray for 285,000 CpG sites in the mouse genome (2022) (6)
Epigenetic Mechanisms in Cancer Development (2017) (6)
Molecular Context-Dependent Effects Induced by Rett Syndrome-Associated Mutations in MeCP2 (2020) (6)
Altered Long Non-coding RNA Expression in Cancer: Potential Biomarkers and Therapeutic Targets? (2019) (5)
Stabilization Effect of Intrinsically Disordered Regions on Multidomain Proteins: The Case of the Methyl-CpG Protein 2, MeCP2 (2021) (5)
Human Cancer Epigenetics (2013) (5)
Single-Cell Technologies and Analyses in Hematopoiesis and Hematological Malignancies. (2021) (5)
ALTERATIONS IN DISEASE (5)
Economic Analysis Of Epicup, An Epigenetic Test To Predict The Tissue Of Origin In Cancer Of Unknown Primary Site, The Usa Payors Perspective. (2015) (5)
Germline missense pathogenic variants in the BRCA1 BRCT domain, p.Gly1706Glu and p.Ala1708Glu, increase cellular sensitivity to PARP inhibitor olaparib by a dominant negative effect. (2016) (5)
The Challenge of Diagnosing Constitutional Mismatch Repair Deficiency Syndrome in Brain Malignancies from Young Individuals (2021) (5)
Direct metabolic regulation of β-catenin activity by the p85α regulatory subunit of phosphoinositide 3-OH kinase (2005) (5)
Analysis of the circRNA and T-UCR populations identifies convergent pathways in mouse and human models of Rett syndrome (2021) (5)
Synthetic Conjugates of Ursodeoxycholic Acid Inhibit Cystogenesis in Experimental Models of Polycystic Liver Disease (2020) (5)
Exploiting the complexity of the genome and transcriptome using pharmacogenomics towards personalized medicine (2011) (5)
Epigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C): A multicenter, retrospective study (2022) (5)
IDIBELL cancer conference on metastasis and angiogenesis. (2011) (5)
Exploiting tumor vulnerabilities: epigenetics, cancer metabolism and the mTOR pathway in the era of personalized medicine. (2013) (5)
The PDGFRb–AKT Pathway Contributes to CDDP-Acquired Resistance in Testicular Germ Cell Tumors (2014) (5)
SIRT 6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv 39 h 1 regulates the NF-κB pathway (2017) (5)
KAT 6 B Is a Tumor Suppressor Histone H 3 Lysine 23 Acetyltransferase UndergoingGenomic Loss in Small Cell Lung Cancer (2015) (5)
Epigenetic drugs: More than meets the eye (2017) (5)
Stem Cell Technology for (Epi)genetic Brain Disorders. (2017) (5)
The transcribed ultraconserved region uc.160+ enhances processing and A‐to‐I editing of the miR‐376 cluster: hypermethylation improves glioma prognosis (2021) (5)
Insights from the genetic and transcriptional characterization of a cancer of unknown primary (CUP) (2020) (4)
Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (2010) (4)
DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques and blood tissues (2020) (4)
Epitranscriptomics in Hematopoiesis and Hematologic Malignancies. (2020) (4)
Discovery of novel DNA methylation biomarkers for non‐invasive sporadic breast cancer detection in the Latino population (2020) (4)
DNA methylome in visceral adipose tissue can discriminate patients with and without colorectal cancer (2021) (4)
A phase II clinical trial to analyze olaparib response in patients with BRCA1 and/or BRCA2 promoter methylation with advanced breast cancer (GEICAM/2015-06 COMETA-Breast study). (2018) (4)
Unraveling the Complex Network of Interactions Between Noncoding RNAs and Epigenetics in Cancer (2014) (4)
Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study (2020) (4)
Genomic DNA Hypomethylation is a Biomarker for Bladder Cancer Susceptibility in the Spanish Bladder Cancer Case-Control Study (2008) (4)
Infinium DNA Methylation Microarrays on Formalin-Fixed, Paraffin-Embedded Samples. (2018) (4)
Epigenetics and Cancer DNA Methylation (2008) (4)
Complete Loss of EPCAM Immunoexpression Identifies EPCAM Deletion Carriers in MSH2-Negative Colorectal Neoplasia (2020) (4)
Genetic and epigenetic defects of the RNA modification machinery in cancer. (2022) (4)
DNA methylation-associated dysregulation of transfer RNA expression in human cancer (2022) (4)
Direct metabolic regulation of beta-catenin activity by the p85alpha regulatory subunit of phosphoinositide 3-OH kinase. (2005) (4)
Experimental and Bioinformatic Approaches to Studying DNA Methylation in Cancer (2022) (4)
Epigenetic Awakening of Viral Mimicry in Cancer. (2020) (4)
Advances in Brief p 14 ARF Silencing by Promoter Hypermethylation Mediates Abnormal Intracellular Localization of MDM 21 (2001) (4)
Novel Targeting of DNA Methyltransferase Activity Inhibits Ewing Sarcoma Cell Proliferation and Enhances Tumor Cell Sensitivity to DNA Damaging Drugs by Activating the DNA Damage Response (2022) (4)
Molecular portrait of high alpha-fetoprotein in hepatocellular carcinoma: implications for biomarker-driven clinical trials (2019) (3)
Physical Activity and Genome-wide DNA Methylation: The REGICOR Study. (2019) (3)
K. Steinberg (ed). The Genetic Basis of Cancer (2002) (3)
Qualitative Determination of 5-Methylcytosine and Other Components of the DNA Methylation Machinery: Immunofluorescence and Chromatin Immunoprecipitation (2004) (3)
Noninvasive early detection of colorectal cancer by hypermethylation of the LINC00473 promoter in plasma cell-free DNA (2022) (3)
Follow-Up Study Confirms the Presence of Gastric Cancer DNA Methylation Hallmarks in High-Risk Precursor Lesions (2021) (3)
A Tumor Suppressor Enhancer of PTEN in T-cell Development and Leukemia. (2021) (3)
Genetic Predisposition to Alzheimer’s Disease Is Associated with Enlargement of Perivascular Spaces in Centrum Semiovale Region (2021) (3)
Epigenetic Regulation of Gfi1 in Endocrine-Related Cancers: A Role Regulating Tumor Growth (2020) (3)
SirT7 auto-ADP-ribosylation regulates glucose starvation response through macroH2A1.1 (2019) (3)
Remodeling of the m6A RNA landscape in the conversion of acute lymphoblastic leukemia cells to macrophages (2022) (3)
Potential Role of Children in the Household Transmission of SARS-CoV-2 Infection in Catalonia (Spain) (2020) (3)
The B cell transcription program mediates hypomethylation and overexpression of key genes in Epstein-Barr virus-associated proliferative conversion (2013) (3)
Economic Analysis Of Epicup, An Epigenetic Test To Predict The Tissue Of Origin In Cancer Of Unknown Primary Site, From The Spanish Nhs Perspective. (2015) (3)
Melo et al. reply (2010) (3)
Influence of the disordered domain structure of MeCP2 on its structural stability and dsDNA interaction. (2021) (3)
Crosstalk Between Non-Coding RNAs and the Epigenome in Development (2017) (3)
Novel genetic variants of KHDC3L and other members of the subcortical maternal complex associated with Beckwith–Wiedemann syndrome or Pseudohypoparathyroidism 1B and multi-locus imprinting disturbances (2022) (3)
International Consensus on the Initial Diagnostic Workup of Cancer of Unknown Primary. (2022) (3)
Look-alike humans identified by facial recognition algorithms show genetic similarities. (2022) (3)
Beyond the genetic lesions: gene inactivation by promoter hypermethylation in human cancer (2000) (3)
Abstract 484: Epigenetic regulation of hsa-miR-3663 in colon cancer (2017) (3)
Novel genetic variants of KHDC3L and other members of the subcortical maternal complex associated with Beckwith–Wiedemann syndrome or Pseudohypoparathyroidism 1B and multi-locus imprinting disturbances (2022) (3)
7 - DNA Methylation Analysis of Human Cancer (2005) (3)
Resistance to PI3Kδ inhibitors in marginal zone lymphoma can be reverted by targeting the IL-6/PDGFRA axis (2022) (3)
DNA Methylation and Ischemic Stroke Risk: An Epigenome-Wide Association Study. (2022) (3)
The Breast Cancer Oncogene EMSY Represses Transcription of Antimetastatic microRNA miR-31 (2014) (3)
Retraction: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function (2016) (3)
Phase II study of temozolomide (TMZ) in metastatic colorectal cancer (mCRC) patients molecularly selected by MGMT promoter hypermethylation. (2015) (3)
Epigenetics, the role of DNA methylation. (2003) (3)
German-Catalan workshop on epigenetics and cancer (2013) (3)
Medina et al., “Genetic and Epigenetic Screening for Gene Alterations of the Chromatin‐Remodeling Factor, SMARCA4/BRGI, in Lung Tunors”. Genes Chromosomes Cancer 2004; 41:170–177 (2005) (2)
Cancer epigenetics in clinical practice. (2022) (2)
Corrigendum: A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect (2016) (2)
Editorial: To the readers and future authors of Critical Reviews in Oncogenesis (2006) (2)
Inactivation of Glutathione 5-Transferase PI Gene by Promoter Hypermethylation in Human Neoplasia1 (1998) (2)
Targeting melanoma: unusual epigenetics reveals the dynamic rewiring of metastatic cells. (2015) (2)
Gene Amplification-Associated Overexpression of the Selenoprotein tRNA Enzyme TRIT1 Confers Sensitivity to Arsenic Trioxide in Small-Cell Lung Cancer (2021) (2)
TMPRSS4 protein overexpression and its promoter hypomethylation predict poor prognosis in squamous lung cancer patients (2016) (2)
Multisystem inflammatory syndrome in children and SARS-CoV-2 variants: a two-year ambispective multicentric cohort study in Catalonia, Spain (2023) (2)
How CpG Island Hypermethylation Leads to Cancer Dissemination: The Sounds of Silence for Tumor and Metastasis Suppressor Genes (2005) (2)
Corrigendum: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function (2010) (2)
Re: A DNA repair pathway-focused score for prediction of outcomes in ovarian cancer treated with platinum-based chemotherapy. (2012) (2)
Epigenome‐wide three‐way interaction study identifies a complex pattern between TRIM27, KIAA0226, and smoking associated with overall survival of early‐stage NSCLC (2021) (2)
Extramedullary multiple myeloma patient-derived orthotopic xenograft with a highly altered genome: combined molecular and therapeutic studies (2021) (2)
Corrigendum: H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells. (2019) (2)
TGF-β oncogenic pathway in HCC: PMEPA1 as a biomarker of treatment response (2017) (2)
The human epigenome—implications for the understanding of human disease (2020) (2)
486 DISCOVERY OF DNA HYPERMETHYLATION OF BDNF, SOX9 AND PMF1 ASSOCIATED WITH BLADDER CANCER PROGRESSION USING CPG ISLAND ARRAYS (2007) (2)
Detection of Lymph Node Micrometastases by Gene Promoter Hypermethylation in Samples Obtained by Endosonography-Guided Fine-Needle Aspiration Biopsy (EUS-FNA) (2004) (2)
Epigenetic landscape in the kick-and-kill therapeutic vaccine BCN02 clinical trial is associated with antiretroviral treatment interruption (ATI) outcome (2022) (2)
Correction: CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer (2018) (2)
Abstract 4734: miR-9-5p expression in breast cancer correlates with hormone receptor status and affects patients survival (2017) (2)
Epigenetic activation of antiviral sensors and effectors of interferon response pathways during SARS-CoV-2 infection (2022) (2)
Modulation of Colorectal Tumor Behavior via lncRNA TP53TG1-Lipidic Nanosystem (2021) (2)
Digital PCR quanti fi cation of MGMT methylation re fi nes prediction of clinical bene fi t from alkylating agents in glioblastoma and metastatic colorectal cancer (2015) (2)
Methylated DNA‐binding Proteins (2006) (2)
Regulation of DNAMethylation Patterns by CK 2-Mediated Phosphorylation of Dnmt 3 a (2017) (2)
Publisher Correction: MethCORR modelling of methylomes from formalin-fixed paraffin-embedded tissue enables characterization and prognostication of colorectal cancer (2020) (2)
Biological and Molecular Factors Predicting Response to Adoptive Cell Therapies in Cancer (2022) (1)
Extramedullary multiple myeloma patient-derived orthotopic xenograft with a highly altered genome: combined molecular and therapeutic studies. (2021) (1)
Cancer epigenetics and methylation [3] (multiple letters) (2002) (1)
Integrating gene expression and epidemiological data for the discovery of genetic interactions associated with cancer risk. (2014) (1)
N-BLR, a primate-specific non-coding transcript, modulates the epithelial-to-mesenchymal transition and leads to colorectal cancer invasion and migration (2014) (1)
The Fundamental Role of Epigenetic Regulation in Normal and Disturbed Cell Growth, Differentiation, and Stemness (2014) (1)
Re-Expression of Fetal Igf2 as Epidriver and Target for Therapy in Hcc (2016) (1)
Epigenetics and Cancer (2008) (1)
Refinement of computational identification of somatic copy number alterations using DNA methylation microarrays illustrated in cancers of unknown primary (2022) (1)
The Future of Discoveries in Breast and Reproductive Cancers: The Genome and Epigenetics (2009) (1)
26 Human Cancer Epigenetics (2012) (1)
The PEG13-DMR and brain-specific enhancers dictate imprinted expression within the 8q24 intellectual disability risk locus (2014) (1)
Genetics and epigenetics of leukemia and lymphoma: from knowledge to applications, meeting report of the Josep Carreras Leukaemia Research Institute (2020) (1)
Epigenetic Changes in Cancer-The Scientist-Magazine of the Life Sciences (2011) (1)
Resource A Landscape of Pharmacogenomic Interactions in Cancer Graphical Abstract Highlights (2016) (1)
Epigenetics of Colorectal Cancer (2010) (1)
DNA methylation signature to identify treatment response in triple negative breast cancer. (2015) (1)
[Spontaneous subgaleal haematoma presenting as an alteration in platelet function]. (2014) (1)
Luring BRCA 1 to the Scene of the Crime (2013) (1)
CARM1 and BAF155: an example of how chromatin remodeling factors can be relocalized and contribute to cancer (2014) (1)
96 INVITED Human Cancer Epigenetics (2011) (1)
suppressor genes as candidate dosage-dependent tumor TRAIL-R2 and TRAIL-R1 Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: (2011) (1)
Abstract 432: Loss of MGMT promoter methylation and resistance to cisplatin in non-seminomatous germ cell tumors (2016) (1)
associated with human cancer The dynamic DNA methylomes of double-stranded DNA viruses Material Supplemental (2009) (1)
Evaluation of stool melting curve analysis of methylated CpG island promoters as an alternative for early noninvasive diagnosis of colorectal tumors. (2009) (1)
Economic analysis of epicup, an epigenetic test to predict the tissue of origin in cancer of unknown primary site. (2015) (1)
Genetically predicted telomere length and Alzheimer’s disease endophenotypes: a Mendelian randomization study (2020) (1)
Abstract 2130A: Epigenetic silencing of TGFβ1, BCL6, KILLIN and CTSZ is related to trastuzumab resistance in HER2-positive breast cancer models (2016) (1)
CARM1 and BAF155: an example of how chromatin remodeling factors can be relocalized and contribute to cancer (2014) (1)
HDAC2 (histone deacetylase 2) (2011) (1)
E-23. A DNA methylation profile of lung cancer (2003) (1)
Abstract 2936: Molecular characterization of the immune subclass of hepatocellualr carcinoma (2017) (1)
Epigenetic Mouse Models (2012) (1)
Correction: Lymphangioleiomyomatosis Biomarkers Linked to Lung Metastatic Potential and Cell Stemness (2018) (1)
in Human Cancer Cells Genetic Unmasking of an Epigenetically Silenced microRNA (2007) (1)
Epigenetics and Cancer Histone Modifications (2008) (1)
33PDNA methylation signature to identify trastuzumab response in HER2 breast cancer models (2017) (1)
Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease (2021) (1)
An Introduction to Epigenetics (2008) (1)
A DNA methylation fingerprint of 1 , 628 human samples Material (2011) (1)
Dynamic epigenetic age mosaicism in the human atherosclerotic artery (2022) (1)
Global Consensus on the Initial Diagnostic Workup of Cancer of Unknown Primary (2022) (1)
DNA Methylation Analysis by Bisulfite Sequencing (BS) (PROT34) (2007) (1)
Impact of the Epigenetically Regulated Hoxa-5 Gene in Neural Differentiation from Human Adipose-Derived Stem Cells (2021) (1)
DNA methylation as an epigenetic signature predictive of response to neodjuvant treatment in TNBC patients. (2018) (1)
Hematoma subgaleal espontáneo como manifestación de una alteración de la función plaquetaria (2014) (1)
DNA methylation in cancer: From mouse to human and back again (2021) (1)
Tackling the translational challenges of multi-omics research in the realm of European personalised medicine: A workshop report (2022) (1)
Molecular characterization of the immune class of hepatocellular carcinoma (2017) (1)
Abstract PL01-03: Epigenetics, aging, and cancer: From DNA methylation to microRNAs (2010) (1)
IMPACT OF APOE GENETIC VARIANT ON BRAIN MORPHOLOGY IN A COHORT OF COGNITIVELY HEALTHY MIDDLE-AGED INDIVIDUALS WITH ENRICHED GENETIC RISK FOR ALZHEIMER’S DISEASE (2017) (1)
Abstract 3827: Caveolin-1 acts as a tumor suppressor promoting muscular differentiation in alveolar rhabdomyosarcomas. (2013) (1)
A timely, user-friendly analysis of the mouse DNA methylome (2022) (1)
PRC2 Loss and DNMT Inhibition Boost Viral Mimicry in Cancer. (2022) (0)
Arbitrarily Primed-PCR and Related DNA Methylation Methodologies (2004) (0)
Abstract 3483: Genome-wide analysis of the antisense transcriptome in cancer (2017) (0)
CpG island promoter hypermethylation of the BRCA1-binding protein SRBC occurs in the context of a wild-type BRCA1 in breast cancer (2006) (0)
Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors (2017) (0)
Cancer Therapy : Preclinical Lurbinectedin ( PM 01183 ) , a New DNA Minor Groove Binder , Inhibits Growth of Orthotopic Primary Graft of Cisplatin-Resistant Epithelial Ovarian Cancer (2012) (0)
Case history: Lessons learned from the MGMT methylation experience (2006) (0)
REDUCED ENTORHINAL GRAY MATTER VOLUME IN HEALTHY AMYLOID-NEGATIVE APOE-E4 HOMOZYGOTES OF THE ALFA COHORT (2018) (0)
K- ras and p16 Aberrations C onfer P oor P rognosis i n Human C olorectal C ancer (2001) (0)
A new approach to epigenome-wide discovery of non-invasive methylation biomarkers for colorectal cancer screening in circulating cell-free DNA using pooled samples (2018) (0)
DNA methylation contributes to natural human variation Material Supplemental (2013) (0)
DNA methylation-associated dysregulation of transfer RNA expression in human cancer (2022) (0)
IV. Epigenetics: what it is and what it can bring (2011) (0)
Abstract 2630: Integration of tumor microenvironment and molecular subclassification of colorectal cancer identifies patient subsets with poor prognosis (2016) (0)
Alteration of the p53 and Rb tumor suppressor pathways by p16/INK4a and p14/ARF promoter methylation and loss of protein expression in recurrent and nonrecurrent meningiomas. (2013) (0)
GPR183 mediates the capacity of the novel CD47-CD19 bispecific antibody TG-1801 to heighten ublituximab-umbralisib (U2) anti-lymphoma activity (2022) (0)
Cancer Therapy : Preclinical The PDGFR b – AKT Pathway Contributes to CDDP-Acquired Resistance in Testicular Germ Cell Tumors (2014) (0)
OA08.07 Aberrant Epigenetic SMAD3 Signaling in Tumor-Associated Fibroblasts Modulates Fibrosis and Response to Nintedanib in NSCLC (2019) (0)
A Changing Epigenome in Health and Disease (2009) (0)
An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma (2023) (0)
N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration (2017) (0)
Abstract 3013: Study of three-dimensional cell culturing influence on DNA methylation profile (2011) (0)
Advances in Brief Inactivation of Glutathione 5-Transferase PI Gene by Promoter Hypermethylation in Human Neoplasia 1 (2006) (0)
ChIP-on-chip: searching for novel transcription factor targets (2007) (0)
New insights into sperm DNA methylation: intra-and inter individual stability and a comparative analysis versus somatic cells (2012) (0)
Phase II study of dacarbazine for metastatic colorectal cancer with determined MGMT status. (2017) (0)
Genetic syndromes caused by mutations in epigenetic genes (2013) (0)
Journal club: epigenetic profiling to classify cancer of unknown primary - Authors' reply. (2017) (0)
MiR-193b promoter methylation accurately detects prostate cancer in urine sediments and miR-34b/c or miR-129-2 promoter methylation define subsets of clinically aggressive tumors (2017) (0)
hSRBC promoter CpG island hypermethylation as resistant predictive biomarker of oxaliplatin based chemotherapy in metastasic colorectal cancer patients. (2013) (0)
Validation of the new EPIC DNA methylation microarray (900K EPIC v2) for high-throughput profiling of the human DNA methylome (2023) (0)
Abstract 3820: Epigenetic re-expression of fetal IGF2 as therapeutic target in hepatocellular carcinoma (2016) (0)
S17 Epigenetic biomarkers in human cancer (2007) (0)
Clinical epigenetics: seizing opportunities for translation (2018) (0)
Bone Marrow WT1 mRNA Upregulation in Acute Myeloid Leukemia (AML) in Complete Molecular Remission (mCR): Understanding the Limitations and Advantages of WT1 As a Measurable Residual Disease (MRD) Target (2022) (0)
DLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation and metabolic remodeling. (2023) (0)
Epigenomic Analysis of Acute Myeloid Leukemia Identifies Specific Patterns and Markes with Clinical and Biological Relevance. (2009) (0)
Abstract 466: A novel DNA methylation-based approach for molecular subtyping and improved prognostication of colorectal cancer using formalin-fixed and paraffin-embedded tissue (2019) (0)
A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97 (2018) (0)
Cancer genomics identifies disrupted epigenetic genes (2013) (0)
Abstract 4904: High levels of microRNA-210-3p are associated with increased risk of disease progression in breast cancer patients treated with docetaxel (2019) (0)
544 Genomic Analysis of DNA Methylation and Copy Number Changes in Breast Cancer (2012) (0)
Faculty Opinions recommendation of Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. (2016) (0)
Walking pathways with positive feedback loops reveal DNA methylation biomarkers of colorectal cancer (2019) (0)
Epigenetics in urogenital cancer (2017) (0)
Examining DNA–Protein Interactions with Genome-Wide Chromatin Immunoprecipitation Analysis (2010) (0)
Abstract 2763: DNA methylation profiling unveils TGF-β hyperresponse in tumor associated fibroblasts from lung cancer patients (2016) (0)
Monographs editor: manel esteller. (2011) (0)
DDR1 methylation is associated with bipolar disorder and the isoform expression and methylation of myelin genes. (2021) (0)
SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway (2018) (0)
Abstract LB-155: Identification of a DNA methylation signature in liquid biopsy for early non-small cell lung cancer (NSCLC) diagnosis (2016) (0)
54 MGMT methylation assessed by methyl-BEAMing technique is a prognostic and predictive biomarker in glioblastoma and metastatic colorectal cancer patients (2014) (0)
Abstract 4252: Redefining the DNA methylome of prostate cancer using DNA methylation arrays. (2013) (0)
Results Comparison of DNA Methylation Profiles of Symptomatic and Asymptomatic Carotid Atherosclerotic Plaques (0)
466 IGF2 drives IGF oncogenic signaling in HCC and emerges as a potential target for therapies (2014) (0)
The Role of Epigenetic Alterations in Cancer (2007) (0)
Quantitative Determination of 5-Methylcytosine DNA Content: HPCE and HPLC (2004) (0)
Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders (2017) (0)
Abstract 4725: Efficacy of a new small-molecule inhibitor of histone deacetylase 6 (HDAC6) in preclinical models of B-cell lymphoma and acute myeloid leukemia (2019) (0)
Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study (2022) (0)
Cellular and clinical impact of Protein Phosphatase Enzyme epigenetic silencing in multiple cancer tissues (2022) (0)
PS-011-New synthetic conjugates of ursodeoxycholic acid inhibit hepatorenal cystogenesis in experimental models of polycystic liver disease (2019) (0)
Abstract IA19: Cancer epigenomics: From knowledge to applications (2016) (0)
Epigenetic modifications in KDM lysine demethylases associate with survival of early-stage NSCLC (2018) (0)
84 IDENTIFICATION OF INTERLEUKIN-16 AS A NOVEL EPIGENETICALLY-REGULATED FACTOR IN CHONDROGENIC DIFFERENTIATION OF ADULT STEM CELLS (2011) (0)
Local IL-17 orchestrates skin aging (2022) (0)
Abstract 2924: Genome-wide microarray platforms uncover novel hypermethylated genes in an oral squamous cell carcinoma case-control study: A phase I preclinical biomarker development study (2010) (0)
Whole exome sequencing of Rett syndrome-like patients reveals the mutational diversity of the clinical phenotype (2016) (0)
Noninvasive early detection of colorectal cancer by hypermethylation of the LINC00473 promoter in plasma cell-free DNA (2022) (0)
List of contributors (2020) (0)
IκBα controls dormancy induction in Hematopoietic stem cell development via retinoic acid (2022) (0)
MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer author ( s ) list : (0)
Abstract A40: Epigenomic profiling identifies NCRNAs as novel tumor suppressors in developmental tumors (2016) (0)
Methylation inactivates critical pathways in tumourgenesis (1999) (0)
The transcribed pseudogene RPSAP52 enhances the oncofetal HMGA2-IGF2BP2-RAS axis through LIN28B-dependent and independent inhibition of let-7 miRNAs (2019) (0)
PM20D1 is a quantitative trait locus associated with Alzheimer’s disease (2018) (0)
Effect of genetic ancestry on leukocyte global DNA methylation in cancer patients (2015) (0)
Integrative ensemble modelling of cetuximab sensitivity in colorectal cancer PDXs (2023) (0)
Disruption of the RNA modifications that target the ribosome translation machinery in human cancer (2020) (0)
Induced Transdifferentiation of Leukemia B-Cells to Macrophages Involves Reconfiguration of the DNA Methylome (2018) (0)
Methode de prediction de la reaction clinique a un traitement chimiotherapeutique avec des agents alkylants (2001) (0)
DNA Methylation Alterations in Systemic Lupus Erythematosus (2009) (0)
DNA methylation biomarkers of myocardial infarction and cardiovascular disease (2021) (0)
Correction to: DNA methylation-based reclassification of olfactory neuroblastoma (2018) (0)
The Human Epigenome (2010) (0)
First Description of an Enteric-Type Adenocarcinoma with a High-Grade Neuroendocrine Component of the Lung (2021) (0)
MiR-204 silencing in intraepithelial to invasive cutaneous squamous cell carcinoma progression (2016) (0)
Abstract 1225: Aberrant SMAD3 signaling in tumor-associated fibroblasts modulates fibrosis and response to the anti-fibrotic drug nintedanib in non-small cell lung cancer (2019) (0)
DNA methylation in melanoma progression (2006) (0)
longitudinal of (2002) (0)
PRS103 - SMARTPHONE APPLICATION FOR THE ASTHMA RESEARCH IN CHILDREN AND ADOLESCENTS (ARCA) COHORT: A PILOT STUDY (2018) (0)
INEFFICIENT METHYL GROUP ASSIMILATION PATHWAY IS RELATED WITH THE DEVELOPMENT AND SEVERITY OF ALZHEIMER'S DISEASE (2011) (0)
Unexpected thermodynamic signature for the interaction of hydroxymethylated DNA with MeCP2. (2023) (0)
ANTITUMORAL ACTIVITY OF THE NOVEL BTK INHIBITOR TG‐1701 IS ASSOCIATED WITH DISRUPTION OF IKAROS SIGNALING AND IMPROVEMENT OF ANTI‐CD20 THERAPY IN B‐CELL NON‐HODGKIN LYMPHOMA (2021) (0)
MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer (2023) (0)
A trans‐omics assessment of gene–gene interaction in early‐stage NSCLC (2022) (0)
Publisher Correction: MethCORR modelling of methylomes from formalin-fixed paraffin-embedded tissue enables characterization and prognostication of colorectal cancer (2020) (0)
Abstract 612: Methylation changes in DNA of CD8 T cells following CD137 costimulation (2017) (0)
BRAIN MORPHOMETRICAL CORRELATES UNDERLYING COGNITIVE PERFORMANCE IN A GENETICALLY ENRICHED SAMPLE OF HEALTHY INDIVIDUALS AT RISK FOR ALZHEIMER’S DISEASE (2017) (0)
IN THE SPOTLIGHT epigenetic Awakening of Viral Mimicry in Cancer (2020) (0)
ErythematosusThe Epigenetic Face of Systemic Lupus (2006) (0)
MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2 (2019) (0)
Epigenetics and Reinventing Lamarck (2011) (0)
IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation (2016) (0)
136 POSTER Discovery of DNAa hypermethylation targets associated with baldder cancer progression using CpG island microarrays (2006) (0)
Air pollution has a more deleterious effect on Alzheimer’s disease biomarkers in genetic predisposition to larger hippocampal volumes (2022) (0)
Forecasting limits in personalised medicine (2012) (0)
Marie Curie – Genome Architecture in Relation to Disease (2008) (0)
25 Proffered Paper: Involvement of Epigenetics in the Early Stages of NSCLC Development (2012) (0)
Human Primary Tumors Susceptibility to DNA Methylation in Normal Tissues and GermLine Variants in Methyl-Group Metabolism Genes and Updated Version (2002) (0)
O93 GENE EXPRESSION-BASED PROGNOSTIC SIGNATURE AND GENOMIC CHARACTERIZATION OF FIBROLAMELLAR HEPATOCELLULAR CARCINOMA (2014) (0)
Aberrant promoter methylation in sputum and serum for lung cancer detection (2002) (0)
[Introduction to molecular biology of endometrial cancer]. (1996) (0)
Cover Image (2020) (0)
Cancer Metastasis: Metastasis Genes: Epigenetics (2011) (0)
PHARMACOLOGICAL UNMASKING OF ABERRANTLY HYPERMETHYLATED miRNAs IN HUMAN CANCER METASTASIS (0)
Arachidonic and Oleic Acid Exerts Distinct Effects on DNA Methylome (2016) (0)
323 Human cancer epigenetics: from DNA methylation to microRNAs (2010) (0)
Mousemodels in epigenetics : insights in development and disease (2013) (0)
A Mouse Skin Multistage Carcinogenesis Model That Unmasks Epigenetic Lesions Responsible for Metastasis (2005) (0)
Abstract 835: Epigenetic biomarkers of chemoresistance in colorectal cancer (2012) (0)
White matter microstructure is altered in cognitively normal middle-aged APOE-ε4 homozygotes (2018) (0)
CpG Island Hypermethylation, miRNAs, and Human Cancer (2008) (0)
Reply to “HDAC2 deficiency and histone acetylation” (2008) (0)
Abstract 1422: Clinical association of miR-155-5p with breast cancer and its relevance for treatment with PARP inhibitors (2020) (0)
BRCA1 as a tumor suppressor linked to the regulation of epigenetic states: keeping oncomiRs under control (2012) (0)
Predictive value of integrative epigenetic profiling in metastatic melanoma (MM) patients (p) treated with BRAF/MEK inhibitors (BMI) and chemotherapy (CT). (2015) (0)
Epigenetics in health and disease : beyond the DNA sequence. (2019) (0)
Faculty Opinions recommendation of Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. (2011) (0)
Aberrant mRNA Stability Regulation in Human Diseases (2006) (0)
Abstract 4784: Effect of epigenetic drugs on chromatin remodeling complexes disrupted in cancer (2015) (0)
Integrated Systems and Technologies ModelingLungCancerEvolutionandPreclinicalResponseby Orthotopic Mouse Allografts (2014) (0)
Epigenomic analysis detects aberrant super-enhancer DNA methylation in human cancer (2016) (0)
studies with normal human melanocytes and melanoma cell lines isolated from primary and metastatic tumors and clinical melanoma metastases revealed that thymosin b4 is specifically up-regulated in metastatic human melano- (2006) (0)
High performance capillary electrophoresis (HPCE) as a powerful tool to study overall genomic changes in DNA methylation, CpG islands, repeat sequences, histone acetylation and histone methylation in cancer (2004) (0)
Advances in Brief Gene Promoter Hypermethylation in Tumors and Serum of Head and Neck Cancer Patients 1 (2000) (0)
Genome-wide study of chromatin remodeling factor CHD8 role in transcription (2011) (0)
Epigenetic control of influenza virus: role of H3K79 methylation in interferon-induced antiviral response (2018) (0)
ERBB4-mediated signaling is a mediator of resistance to BTK and PI3K inhibitors in B cell lymphoid neoplasms (2023) (0)
Abstract 1819: Non-coding RNAs as key players for understanding oncogenic pathways in ovarian cancer: Studying new therapeutic strategies (2019) (0)
TITLE : IGF 2 is up-regulated by epigenetic mechanisms in hepatocellular 1 carcinoma and is an actionable oncogene in experimental models (2016) (0)
Abstract 1366: Discovery of biomarkers for antitumor drug resistance using 450K methylation data of NCI60 (2014) (0)
Abstract 3883: Clonal evolution of a lethal prostate cancer: Integrated whole genome analysis case study (2015) (0)
VAV3 mediates resistance to breast cancer endocrine therapy (2014) (0)
White Matter Microstructure Is Altered In Cognitively Normal Middle-aged Apoe-epsilon 4 (2018) (0)
Disruption of NIPBL/Scc2 in Cornelia de Lange Syndrome provokes cohesin genome-wide redistribution with an impact in the transcriptome (2021) (0)
Clonal evolution of a lethal prostate cancer: Integrated whole genome analysis case study (2015) (0)
Abstract S4-8: Promoter CpG Methylation ofBRCA1Predicts Sensitivity to PARP Inhibitors in Breast Cancer (2010) (0)
Molecular-based tumor cell screening at the lymph nodes of metastatic colorectal cancer patients predicts recurrence (1999) (0)
DNA Methylomes Reveal Biological Networks Involved in Human Eye Development, Functions and Associated Disorders (2017) (0)
Abstract 4021: Breaking the dogma: AWT1 hypermethylation in myeloid leukemia despite high expression (2012) (0)
Cancer pharmaco-epigenetics (2019) (0)
Reply to “Reassessing the TARBP2 mutation rate in hereditary nonpolyposis colorectal cancer” (2010) (0)
Abstract 2770: DERL3 hypermethylation alters rhabdomyosarcoma cell metabolism (2016) (0)
Genetic characterization of the ALFA study: Uncovering genetic profiles in the Alzheimer's continuum. (2023) (0)
Study of the population of immature neurons in the adult piriform cortex layer ii (2019) (0)
Efficacy of a New Small-Molecule Inhibitor of Histone Deacetylase 6 (HDAC6) in Preclinical Models of B-Cell Lymphoma and Acute Myeloid Leukemia (2018) (0)
Primary intracranial spindle cell sarcoma with RMS-like features share a highly distinct methylation profile and DICER1 mutations (0)
WINNER The necessity of a human epigenome project (2006) (0)
Cancer epigenetics: From DNA methylation to histone modifications (2006) (0)
EFFECT OF AGE AND APOE GENOTYPES ON BRAIN MICROSTRUCTURE IN COGNITIVELY HEALTHY SUBJECTS AS MEASURED BY DIFFUSION-WEIGHTED IMAGING (2017) (0)
Epigenetic silencing of TGFBI confers resistance to trastuzumab in human breast cancer (2019) (0)
Abstract PR3: Patient derived BRCA1-deficient triple-negative breast cancer xenografts develop resistance to DNA damaging agents via genetic and epigenetic mechanisms (2012) (0)
Chapter 2 Quantification of Global DNA Methylation by Capillary Electrophoresis and Mass Spectrometry (2019) (0)
Abstract 1845: Genetic analyses of MGMT in familial gliomas and colorectal cancer (2010) (0)
The Histone Deacetylase 9 Gene Is Regulated by Multiple Promoters and Expresses Lymphoid-Specific Isoforms. (2004) (0)
Phase II study of dacarbazine for metastatic colorectal cancer: Final results with MGMT analysis. (2017) (0)
Cancer network activity associated with therapeutic response and synergism (2016) (0)
Abstract 153: Epigenetic loss of NSUN5 in glioma drives a global protein synthesis depletion along with the emergence of a stress adaptive translational program (2020) (0)
G protein-coupled receptor 183 mediates the sensitization of Burkitt lymphoma tumors to CD47 immune checkpoint blockade by anti-CD20/PI3Kδi dual therapy (2023) (0)
Germline mutations in the spindle assembly checkpoint genes BUB1 and BUB3 are infrequent in familial colorectal cancer and polyposis (2018) (0)
Cerebral anatomical alterations in healthy middle-aged ApoE4 carriers (2015) (0)
Epigenomics and Cancer (2008) (0)
CSL–MAML-dependent Notch1 signaling controls T lineage–specific IL-7Rα gene expression in early human thymopoiesis and leukemia (2009) (0)
What is Epigenetics (2008) (0)
P5-06-02: Response and Acquired Resistance of BRCA1-Deficient Triple-Negative Breast Cancer Xenografts to Alkylators or PARP Inhibitors. (2011) (0)
MethCORR modelling of methylomes from formalin-fixed paraffin-embedded tissue enables characterization and prognostication of colorectal cancer (2020) (0)
The chromatin remodeler CHD8 is required for transcription activation of S-phase genes (2013) (0)
109 A novel Werner Syndrome mutation: Pharmacological treatment by read-through of nonsense mutations and epigenetic therapies (2015) (0)
Mod Squad: Altered Histone Modifications in Cancer (2018) (0)
Abstract 3172: Methylation portraits discriminate between hepatocellular carcinoma cases and controls (2011) (0)
Epigenetic Differences in Monozygotic Twins Discordant for Type 2 Diabetes (2009) (0)
Radical fringe facilitates NOTCH1 and JAG1 cis interactions to sustain Hematopoietic stem cell fate (2023) (0)
P1.02-076 DNA Methylation Profiling Unravels a TGF-β Hyperresponse in Tumor Associated Fibroblasts from Lung Cancer Patients: Topic: Other Mutations in Thoracic Malignancies (2017) (0)
Abstract 106: Epigenetic regulation of snoRNAs in cancer (2011) (0)
DNA Methylation-Based Burkitt Lymphoma Epitypes Have Distinct Molecular and Clinical Features (2022) (0)
Loss of MGMT promoter methylation and resistance to cisplatin in non-seminomatous germ cell tumors (2016) (0)
Differences in expression rather than methylation at placenta-specific imprinted loci is associated with intrauterine growth restriction (2019) (0)
Epigenetics of breast cancer (2007) (0)
Profiles of DNA methylation in colorectal cancer. (2004) (0)
2 DNA Methylation and Histone Modifications in Patients With Cancer Potential Prognostic and Therapeutic Targets (2017) (0)
INFLUENCE OF BDNF VAL66MET POLYMORPHISM ON HIPPOCAMPAL SUBFIELDS: MET CARRIERS DISPLAY GREATER SUBICULUM VOLUMES (2019) (0)
Regulación anormal de la estabilidad del ARNm en enfermedades humanas (2006) (0)
9237 Array based CpG island methylation-profiling in acute myelogenous leukemia at diagnosis and relapse (2009) (0)
Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism (2017) (0)
Charting the Spatial Landscape of Cancer Hallmarks (2022) (0)
Non-coding RNAs, epigenetics, and cancer: tying it all together (2018) (0)
A two-gene epigenetic signature for the prediction of response to neoadjuvant chemotherapy in triple-negative breast cancer patients (2019) (0)
BS4 Modelling of stroke risk: an epigenetic and in vitro study (2021) (0)
Sex differences in genetic susceptibility of hippocampal subfields: A polygenic association study (2021) (0)
Abstract 474: Genome-wide DNA methylation profiling reveals novel candidate epigenetic gatekeepers in hepatocarcinogenesis (2019) (0)
MSIMEP: Predicting microsatellite instability from microarray DNA methylation tumor profiles (2023) (0)
Epigenetic profiling identifies MIR10A-5 p as a putative tumor suppresor in Ewing sarcoma and rhabdomyosarcoma (2016) (0)
Abstract 5483: Implications of the type ofBRCA1germline mutation in the treatment of patients with hereditary breast cancer (2014) (0)
Abstract 5416: Positioning the NQO1-bioactivatable drug isobutyl-deoxynyboquinone in diffuse intrinsic pontine glioma (DIPG): an exceptional therapeutic opportunity in pediatric brain tumor (2020) (0)
Abstract PR02: Genomic rearrangements and promoter demethylation drive therapy resistance in patient-derived xenograft models of BRCA1-deficient breast cancer (2013) (0)
‘ ‘ focus on . . . ’ ’ session : profiling and prognosis (2008) (0)
Global Shift in Alternative Splicing and Therapeutic Susceptibilities in Leukemia Driven by METTL3 Overexpression. (2023) (0)
Global Impairment of Immediate-Early Genes Expression in Rett Syndrome Models and Patients Linked to Myelination Defects (2023) (0)
Abstract 2829: Identification of the role of SRBC methylation-associated gene silencing as predictive factor of oxaliplatin secondary resistance in metastasic colorectal cancer patients (2014) (0)
Serum DNA methylome of the colorectal cancer serrated pathway (2022) (0)
P0265 : IGF2 is an oncogenic driver in HCC and emerges as a potential target for therapies (2015) (0)
An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures (2018) (0)
Abstract 5394: Initial results from TRANSCAN ERA-NET BREMIR project: MicroRNAs expression profiling for identification of breast cancer patients at high risk to develop distant metastases (2018) (0)
Global and gene specific DNA methylation as a screening tool for early detection of liver cancer. (2007) (0)
1585: Methylation of Topoisomerase-1 Gene Reduces Risk for Tumor Recurrence after Early Instillation Therapy in Superfical Urothelial Carcinoma (2007) (0)
Epigenetics of breast cancer (2007) (0)
Methylation Markers for Prostate Cancer Pr R a Stem Cell Twist (2010) (0)
Abstract 4091: Identification of epigenetic alterations associated with tumor progression and cancer metastasis (2012) (0)
227 EACR Cancer Researcher Award EACR Cancer Researcher Award: Cancer Epigenetics – From DNA Methylation to Non-coding RNAs (2011) (0)
9 Pharmacoepigenetics and epigenetic drugs (2010) (0)
The DNA methylation drift of the atherosclerotic aorta increases with lesion progression (2015) (0)
Abstract 2018: Genome-wide analysis of DNA methylation and copy number changes in breast cancers. (2013) (0)
69P TGFBI promoter methylation validation as an epigenetic biomarker for trastuzumab resistance in HER2+ breast cancer patients cohort (2020) (0)
Direct comparison of two different strategies to sequence bisulfite-treated genomic DNA for DNA methylation analysis in genetic diseases and cancer samples. (2005) (0)
Abstract 4887: Genetic analyses of chromatin remodelers in cancer (2010) (0)
discordance in systemic lupus erythematosus Changes in the pattern of DNA methylation associate with twin Material Supplemental (2009) (0)
LifelineDu Pasquier obtained his MD from the (2010) (0)
Highly-specific early detection of colorectal cancer by novel non-invasive serum methylation biomarkers (2021) (0)
Abstract LB130: Single-cell multiomics analysis of myelodysplastic syndrome predicts clinical response to DNA methylation inhibitor therapy (2023) (0)
TITLE: Targeted exome sequencing of Krebs cycle genes reveals candidate cancer predisposing mutations in pheochromocytomas and paragangliomas (2017) (0)
DNA methylation alterations in grade II- and anaplastic pleomorphic xanthoastrocytoma (2014) (0)
Polygenic determinants of White Matter Hyperintensities and sex‐specific genetic profiles in the Alzheimer’s continuum (2022) (0)

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